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https://www.readbyqxmd.com/read/29142243/genetic-risk-scores-for-body-fat-distribution-attenuate-weight-loss-in-women-during-dietary-intervention
#1
M Svendstrup, K H Allin, T I A Sørensen, T H Hansen, N Grarup, T Hansen, H Vestergaard
BACKGROUND AND AIM: The well-established link between body fat distribution and metabolic health has been suggested to act through an impact on the remodeling capacity of the adipose tissue. Remodeling of the adipose tissue has been shown to affect body fat distribution and might affect the ability to lose weight. We aimed to study the effect of weighted genetic risk scores (GRSs) on weight loss based on single-nucleotide polymorphisms (SNPs) associated with waist-hip-ratio adjusted for body mass index (WHRadjBMI)...
November 16, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29142011/effect-of-distinct-lifestyle-interventions-on-mobilization-of-fat-storage-pools-the-central-mri-randomized-controlled-trial
#2
Yftach Gepner, Ilan Shelef, Dan Schwarzfuchs, Hila Zelicha, Lilac Tene, Anat Yaskolka Meir, Gal Tsaban, Noa Cohen, Nitzan Bril, Michal Rein, Dana Serfaty, Shira Kenigsbuch, Oded Komy, Arik Wolak, Yoash Chassidim, Rachel Golan, Hilla Avni-Hassid, Avital Bilitzky, Benjamin Sarusi, Eyal Goshen, Elad Shemesh, Yaakov Henkin, Michael Stumvoll, Matthias Blüher, Joachim Thiery, Uta Ceglarek, Assaf Rudich, Meir J Stampfer, Iris Shai
Background -We aimed to assess whether distinct lifestyle strategies can differentially affect specific body adipose depots. Methods -We performed an eighteen-month randomized controlled trial among 278 sedentary adults with abdominal obesity (75%) or dyslipidemia in an isolated workplace with a monitored provided lunch. Participants were randomized to iso-caloric low-fat (LF) or Mediterranean/low-carbohydrate (MED/LC) diet+28g walnuts/day with/without added moderate physical activity (PA;80% aerobic; supervised/free gym membership)...
November 15, 2017: Circulation
https://www.readbyqxmd.com/read/29139371/hailey-hailey-disease-presenting-as-lichenoid-plaques-on-the-thigh
#3
Anupama Ghosh, Anupam Das, Piyush Kumar, Swapan Sardar
A 40-year-old woman presented with multiple itchy violaceous papules and plaques on the medial aspects of both thighs. This was accompanied by a burning sensation on friction and increased itching that interfered with her daily activities, particularly in the summer. The family history was noncontributory. Cutaneous examination showed multiple flat-topped hyperkeratotic violaceous papules and plaques, appearing in linear fashion on the medial aspects of the thighs bilaterally (Figure 1). Histopathologic examination showed acanthosis, widespread suprabasal acantholysis resembling a "dilapidated brick wall," without any evidence of dyskeratosis...
2017: Skinmed
https://www.readbyqxmd.com/read/29135262/a-low-molecular-weight-gelator-composed-of-pyrene-and-fluorene-moieties-for-effective-charge-transfer-in-supramolecular-ambidextrous-gel
#4
Samala Murali Mohan Reddy, Pramod Dorishetty, George Augustine, Abhijit P Deshpande, Niraikulam Ayyadurai, Ganesh Shanmugam
Charge-transfer (CT) gel materials obtained from low-molecular-weight (LMW) compounds through a supramolecular self-assembly approach have received fascinating attention by many researchers because of their interesting material property and potential applications. However, most of the CT gel materials constructed were of organogels while the construction of CT gels in the form of a hydrogel is a challenge because of the solubility issue in water, which considerably limits the use of CT hydrogels. Herein, for the first time, we report a new LMW gelator [N(α)-(fluorenylmethoxycarbonyl)-N(ε)-(δ-butyric-1-pyrenyl)-l-lysine, (FmKPy)], composed of two functional moieties such as fluorenylmethoxycarbonyl and pyrene, which not only parade both hydro and organo (ambidextrous) supramolecular gel formation but also exhibit CT ambidextrous gels when mixed with an electron acceptor such as 2,4,7-trinitro-9-fluorenone (TNF)...
November 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29128556/pro-140-monoclonal-antibody-to-ccr5-prevents-acute-xenogeneic-graft-versus-host-disease-in-nod-scid-il-2ry-null-mice
#5
Denis R Burger, Yvonne Parker, Kathryn Guinta, Daniel Lindner
Graft-versus-Host Disease (GvHD) is a prevalent and potentially lethal complication of hematopoietic stem cell transplantation (HSCT). Humanized mouse models of xenogeneic-GvHD are important tools used to study the human immune response in vivo. Here we used NOD-scid IL-2Ry(null) mice (NSG) transplanted with human bone marrow stem cells to evaluate the role of immune cell engraftment in the production of acute GvHD. PRO 140, a humanized monoclonal antibody targeting the chemokine receptor, CCR5, was used to evaluate its influence on bone marrow cell engraftment and modulation of acute GvHD...
November 8, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29128055/current-treatment-of-nonalcoholic-fatty-liver-disease-nonalcoholic-steatohepatitis
#6
REVIEW
Chun Kit Hung, Henry C Bodenheimer
Treatment of nonalcoholic fatty liver disease (NAFLD)/nonalcoholic steatohepatitis (NASH) is focused on patients with NASH because they are at highest risk for progressive liver disease. Current first-line treatment consists of lifestyle modifications. Patients should lose at least 7% to 10% of body weight via a combination of physical exercise and calorie restriction dieting. Surgical or endoscopic surgery for weight loss can be considered in obese patients, depending on degree of excess body weight and comorbidities...
February 2018: Clinics in Liver Disease
https://www.readbyqxmd.com/read/29120686/why-is-the-heel-particularly-vulnerable-to-pressure-ulcers
#7
Amit Gefen
In this article, the vulnerability of the soft tissues of the heel to pressure ulcers (injuries) is explained from a biomechanical engineering perspective, and emerging technologies for protecting the heel, particularly low-friction garments, are reviewed. Sustained deformations in the soft tissue of the weight-bearing posterior heel cause progressive cell and tissue damage due to loss of homeostasis in the cells, as the cytoskeleton and plasma membranes of the affected cells lose integrity and functionality...
November 8, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29118158/dental-hygienists-attitudes-toward-the-obese-population
#8
Gwen Essex, Keiko Miyahara, Dorothy J Rowe
Purpose: To explore dental hygienists' attitudes toward the obese population and to determine whether there are differences in attitudes among those with different self-reported body images.Methods: The study population was dental hygienists whose email addresses were in the database of the California Dental Hygienists' Association (CDHA). CDHA distributed the electronic message containing study information, informed consent, and a link to the survey. The survey consisted of 14 items from the Fat Phobia Scale, 13 items from the Anti-fat Attitudes Questionnaire (AFAQ), 3 demographic questions, and 1 question on body image...
December 2016: Journal of Dental Hygiene: JDH
https://www.readbyqxmd.com/read/29115719/a-simply-synthesized-tough-polyarylene-with-transient-mechanochromic-response
#9
Fabian Kempe, Oliver Brügner, Hannah Buchheit, Sarah Noemi Momm, Felix Riehle, Sophie Hameury, Michael Walter, Michael Sommer
A simple, straightforward and high-yielding route to tough polyarylenes of type poly(meta,meta,para-phenylene) (PmmpP) is developed. PmmpP is already tough in its as-synthesized state at intermediate molar mass of Mw ~60 kg/mol and exhibits outstanding mechanical properties for further optimized molecular weight (Mw = 96 kg/mol, E = 0.9 GPa, ε = 300 %). Statistical copolymers with para,para spiropyran (SP) are mechanochromic, whereby the tough behavior allows to investigate mechanochromism. Strained samples instantaneously lose color upon force release...
November 8, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29108443/translating-healthy-living-messages-to-postpartum-women-and-their-partners-after-gestational-diabetes-gdm-body-habitus-a1c-lifestyle-habits-and-program-engagement-results-from-the-families-defeating-diabetes-fdd-randomized-trial
#10
R McManus, D Miller, M Mottola, I Giroux, L Donovan
PURPOSE: The Families Defeating Diabetes intervention evaluated a postpartum healthy living program for women with recent gestational diabetes mellitus (GDM). DESIGN: Randomized controlled trial. SETTING: Tertiary centers in London, Calgary, and Victoria, Canada. PARTICIPANTS: Women with GDM and partners; 46% of eligible maternal participants agreed to participate. INTERVENTION: Interventional (INT) participants received a healthy living seminar at 3 months; access to a walking group/Website; biweekly e-mails...
January 1, 2017: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29102588/effect-of-weight-losing-on-the-improving-clinical-statement-of-patients-with-knee-osteoarthritis
#11
Alireza Sadeghi, Zahra Abbaspour Rad, Behnam Sajedi, Amir Hossein Heydari, Samira Akbarieh, Behzad Jafari
OBJECTIVE: Osteoarthritis causes severe pain and disability in joints, one of the most prevalent involved joints is the knee joint. There are several therapeutics ways to control pain and disability, but almost none of them are definite treatment. In this article, we tried to reveal the effect of weight loss on improving symptoms of knee osteoarthritis as an effective and permanent therapeutic approach. METHODS: We chose 62 patients with grade 1-2 (mild to moderate) knee osteoarthritis and divided them equally into case and control groups...
November 1, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29100822/-which-ovarian-stimulation-to-which-women-the-polycystic-ovary-syndrome-pcos
#12
P Merviel, S Bouée, M Ménard, M-T Le Martelot, S Roche, C Lelièvre, J-J Chabaud, C Jacq, H Drapier, D Beauvillard
Polycystic ovarian syndrome (PCOS) is a frequent pathology in the young woman, linking infertility to a metabolic disease. Initial support will include a plan (in the case of overweight or obesity) to lose at least 5 to 10% of the weight. Subsequently, clomiphene citrate is the first treatment for ovulation induction with pregnancy rates of 40 to 80% after 6 cycles. If there is resistance to clomiphene citrate, the choice will be between the ovarian drilling (50-60% of pregnancy in the year following, including the half spontaneous) or ovarian stimulation with gonadotropins...
October 31, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29099476/assessment-of-a-health-promotion-model-on-obese-turkish-children
#13
Berna Eren Fidanci, Nalan Akbayrak, Filiz Arslan
BACKGROUND: Studies of childhood obesity have shown that fostering healthy life behaviors is more important than losing weight. However, studies reporting this result did not use a theoretical nursing model, which offers a systematic approach and scientific basis for studying the concepts and principles of nursing practice. PURPOSE: The aim of this study was to determine the effects of an intervention that is based on Nola J. Pender's Health Promotion Model (HPM) on the healthy life behaviors and self-confidence of obese children...
December 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/29092619/racial-ethnic-differences-in-treatment-recommendations-lifestyle-changes-and-medication-prescriptions-for-high-cholesterol
#14
Emily Bacon
OBJECTIVE: High cholesterol is a common condition in the United States, affecting nearly one third of adults, and is a leading precursor to coronary heart disease. This study investigates race/ethnic differences in treatment recommendations for patients with high cholesterol, including prescription medication and lifestyle changes such as eating less fat, losing weight, or exercising more. DESIGN: Data were obtained from the 2005 to 2010 National Health and Nutrition Examination Survey (N = 4846), a representative sample of adults in the United States, and the 2005-2010 National Ambulatory Medical Care Survey (N = 12,113), a representative sample of patient visits in the United States...
November 2, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/29083096/compressed-sensing-in-quantitative-determination-of-gag-concentration-in-cartilage-by-microscopic-mri
#15
Nian Wang, Farid Badar, Yang Xia
PURPOSE: To evaluate the potentials of compressed sensing (CS) in MRI quantification of glycosaminoglycan (GAG) concentration in articular cartilage at microscopic resolution. METHODS: T1 -weighted 2D experiments of cartilage were fully sampled in k-space with five inversion times at 17.6 μm resolution. These fully sampled k-space data were re-processed, by undersampling at various 1D and 2D CS undersampling factors (UFs). The undersampled data were reconstructed individually into 2D images using nonlinear reconstruction, which were used to calculate 2D maps of T1 and GAG concentration...
October 30, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29082666/internalizing-weight-stigma-prevalence-and-sociodemographic-considerations-in-us-adults
#16
Rebecca M Puhl, Mary S Himmelstein, Diane M Quinn
OBJECTIVE: This study aimed to conduct a comprehensive assessment of the presence, severity, and sociodemographic correlates of weight bias internalization (WBI) across three distinct samples of US adults. METHODS: Levels of WBI were compared in (1) a sample of adults with obesity and heightened risk of weight stigma (N = 456), (2) an online community sample (N = 519), and (3) a national online panel (N = 2,529). Samples 2 and 3 comprised adults with and without obesity...
October 30, 2017: Obesity
https://www.readbyqxmd.com/read/29081067/why-is-it-difficult-to-lose-and-maintain-large-amounts-of-weight-with-lifestyle-and-pharmacologic-treatments
#17
Steven B Heymsfield, Brianna Bourgeois, Diana M Thomas
No abstract text is available yet for this article.
October 29, 2017: Obesity
https://www.readbyqxmd.com/read/29080046/the-microbiome-that-shapes-us-can-it-cause-obesity
#18
REVIEW
Endashaw Omer, Hadi Atassi
PURPOSE OF REVIEW: We sought to examine the effects of the gut microbial makeup on weight gain and obesity. We wanted to find out what the current research on this topic was and what the effect of the gut microbiota on energy metabolism is, as well the effects of diet on the microbiome and what effect the microbiome has on metabolic syndrome. RECENT FINDINGS: Obesity is thought to be due to greater calorie intake than expenditure. Recently, research has looked into the effects of the microbiome on obesity...
October 27, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29077154/the-differentiation-of-beige-adipocyte-in-pericardial-and-epicardial-adipose-tissues-induces-atrial-fibrillation-development
#19
Y He, N Ma, M Tang, Z-L Jiang, H Liu, J Mei
OBJECTIVE: Growing evidence has identified that excessive accumulation of pericardial adipose tissues (PAT) and epicardial adipose tissues (EAT) is associated with atrial fibrillation (AF) development. Moreover, beige adipocytes, present in PAT and EAT, have been proved beneficial in consumption of fatty acid and promotion of weight lose by nonshivering thermogenesis. The objective of this prospective, observational study was to reveal the potential association between beige adipocytes and AF development...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29076176/electronic-cigarette-use-among-individuals-with-a-self-reported-eating-disorder-diagnosis
#20
Meghan E Morean, Alexa L'Insalata
OBJECTIVE: The primary study aim was to examine whether rates of using e-cigarettes ("vaping") to lose weight are elevated among American adults who self-report having an eating disorder (ED). METHOD: Adult vapers who reported either currently having an ED (n = 178; 72.5% women, 83.7% White, mean age 33.26 [SD = 8.35] years) or no ED history (n = 433; 54.7% women, 83.4% White, 35.98 [SD = 11.71] years) completed an anonymous survey. RESULTS: Relative to participants reporting no ED history, participants who reported currently having an ED were more likely to report vaping to lose/control weight, because it can be concealed from others, and due to the availability of sweet flavors...
October 27, 2017: International Journal of Eating Disorders
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