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https://www.readbyqxmd.com/read/29017464/respective-contribution-of-the-cephalic-neural-crest-and-mesoderm-to-six1-expressing-head-territories-in-the-avian-embryo
#1
Barbara F Fonseca, Gérard Couly, Elisabeth Dupin
BACKGROUND: Vertebrate head development depends on a series of interactions between many cell populations of distinct embryological origins. Cranial mesenchymal tissues have a dual embryonic source: - the neural crest (NC), which generates most of craniofacial skeleton, dermis, pericytes, fat cells, and tenocytes; and - the mesoderm, which yields muscles, blood vessel endothelia and some posterior cranial bones. The molecular players that orchestrate co-development of cephalic NC and mesodermal cells to properly construct the head of vertebrates remain poorly understood...
October 10, 2017: BMC Developmental Biology
https://www.readbyqxmd.com/read/28988443/effects-of-supramaximal-balloon-dilatation-pressures-on-adult-cricoid-and-tracheal-cartilage-a-cadaveric-study
#2
Venkata S P B Durvasula, Sara C Shalin, Ozlem E Tulunay-Ugur, James Y Suen, Gresham T Richter
OBJECTIVES/HYPOTHESIS: Cricoid fracture is a serious concern for balloon dilatation in airway stenosis. Furthermore, there are no studies examining tracheal rupture in balloon dilatation of stenotic segments. The aim of this study was to evaluate the effect of supramaximal pressures of balloons on the cricoid and tracheal rings. STUDY DESIGN: Prospective cadaveric study. METHODS: Seven cadaveric laryngotracheal complexes of normal adults with intact cricothyroid membranes were acquired...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28923317/calcified-cartilage-or-bone-collagens-in-the-tessellated-endoskeletons-of-cartilaginous-fish-sharks-and-rays
#3
Ronald Seidel, Michael Blumer, Elisabeth-Judith Pechriggl, Kady Lyons, Brian K Hall, Peter Fratzl, James C Weaver, Mason N Dean
The primary skeletal tissue in elasmobranchs -sharks, rays and relatives- is cartilage, forming both embryonic and adult endoskeletons. Only the skeletal surface calcifies, exhibiting mineralized tiles (tesserae) sandwiched between a cartilage core and overlying fibrous perichondrium. These two tissues are based on different collagens (Coll II and I, respectively), fueling a long-standing debate as to whether tesserae are more like bone (Coll 1-based) or calcified cartilage in their matrix composition. We demonstrate that stingray (Urobatis halleri) tesserae are bipartite, having an upper Coll I-based "cap" that merges into a lower Coll II-based "body" zone, although tesserae are surrounded by cartilage...
September 15, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28892946/indian-perspectives-on-graft-materials-used-for-repair-of-tympanic-membrane
#4
REVIEW
Manu Malhotra, Saurabh Varshney, Rashmi Malhotra, Poonam Joshi
INTRODUCTION: Repair of Tympanic Membrane (TM) is one of the most common surgeries performed by the otologists. Literature reveals that Indian surgeons have contributed substantially in the research on techniques and graft materials used for the repair of tympanic membrane, though no review has been written so far highlighting their contributions. AIM: To summarize and analyse the contributions of Indian authors who have used different graft materials for repair of TM and their studies listed in Medline search...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892941/cartilage-myringoplasty-an-ideal-grafting-technique-for-complex-perforations
#5
Munish Kambatatti Shekharappa, Shruthi Malavalli Siddappa
INTRODUCTION: Tympanoplasty is one of routinely performed surgeries in ENT practice. Using cartilage-perichondrium composite graft in selective cases gives better outcome. AIM: To study the outcome and feasibility of cartilage-perichondrium composite graft in repair of complex tympanic membrane perforations. MATERIALS AND METHODS: This cross-sectional, intervention study was conducted at SSIMS and RC, Tertiary Care Teaching Hospital, Davangere, Karnataka, Southern India...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28806310/the-prevention-of-recurrent-cholesteatoma-in-cwu-surgery-the-use-of-titanium-sheeting
#6
Bruce Black, Ian Gutteridge
OBJECTIVE: Assessment of the outcomes of a technique of prevention of recurrent cholesteatoma in canal wall up (CWU) mastoidectomy, using titanium sheeting to repair the external auditory canal wall. PATIENTS: Sixty four cholesteatoma cases were managed during a period from 2007 to 2015. The cases were unselected; the surgery was performed by the senior author. Cholesteatoma Patterns Were: Forty two attic, nine pars tensa, seven combined attic-pars tensa, three congenital, and three other...
October 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28768899/aberrant-perichondrial-bmp-signaling-mediates-multiple-osteochondromagenesis-in-mice
#7
Toshihiro Inubushi, Satoshi Nozawa, Kazu Matsumoto, Fumitoshi Irie, Yu Yamaguchi
Multiple hereditary exostoses (MHE) is characterized by the development of numerous benign bony tumors (osteochondromas). Although it has been well established that MHE is caused by mutations in EXT1 and EXT2, which encode glycosyltransferase essential for heparan sulfate (HS) biosynthesis, the cellular origin and molecular mechanisms of MHE remain elusive. Here, we show that in Ext1 mutant mice, osteochondromas develop from mesenchymal stem cell-like progenitor cells residing in the perichondrium, and we show that enhanced BMP signaling in these cells is the primary signaling defect that leads to osteochondromagenesis...
August 3, 2017: JCI Insight
https://www.readbyqxmd.com/read/28740761/local-application-of-statins-significantly-reduced-hypertrophic-scarring-in-a-rabbit-ear-model
#8
Shengxian Jia, Ping Xie, Seok J Hong, Robert D Galiano, Thomas A Mustoe
BACKGROUND: We previously showed that intradermal injection of statins is a successful treatment for hypertrophic scarring. Topical application has many advantages over intradermal injection. In this study, we demonstrate the efficacy of topical statin treatment in reducing scar in our validated rabbit ear scar model. METHODS: Twenty New Zealand White rabbits were divided into 2 study groups, with 6 rabbits receiving 10 μm pravastatin intradermally at postoperative days 15, 18, and 21, and 14 rabbits receiving 0...
June 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28614150/exophytic-osteochondroma-of-the-brow
#9
Frederick A Jakobiec, Fouad R Zakka, Nahyoung Grace Lee
Most boney and cartilaginous lesions of the orbit and periorbital compartments are benign, grow endophytically, and are composed of dense lamellar bone (eburnated or ivory osteomas). An 87-year-old woman had a well-circumscribed, firm, round, and exophytic lesion of the brow region for at least 15 years. Excisional surgery disclosed an osteocartilaginous lesion with an enveloping pseudocapsule (periosteum/perichondrium) and a narrow stalk connecting it to the frontal bone. The periphery of the lesion displayed lamellar bone which appeared to be replacing a central cartilaginous zone...
June 13, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28602824/distribution-of-bdnf-and-trkb-isoforms-in-growing-antler-tissues-of-red-deer
#10
M Colitti
Antlers are the cranial appendages of deer that regenerate each year. This renewal provides a model to explore molecules involved in mammalian organ regeneration. The cellular distributions of the brain-derived neurotrophic factor (BDNF) and the isoforms of its cognate receptor Trk tyrosine kinase receptor (TrkB) were localized by immunohistochemistry in sections of growing red deer antler. BDNF and TrkB full length were widely expressed in the integument, perichondrium, periosteum and bone. The truncated isoform receptor was particularly evidenced in integument and vascular inner dermis, but very light reaction was observed in cartilage and bone, both at the site of endochondral and intramembranous ossification...
September 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28585463/endoscopic-lateral-cartilage-graft-tympanoplasty
#11
Cameron C Wick, Demetri Arnaoutakis, Vivian F Kaul, Brandon Isaacson
Objective To describe a novel technique for lateral graft tympanoplasty. Study Design Case series with chart review. Setting Tertiary care university hospital. Subjects and Methods Pediatric and adult patients with tympanic membrane perforations deemed unfavorable for a medial graft technique due to the perforation characteristics or myringitis. Results Between 2014 and 2016, 34 ears from 31 patients underwent a transcanal endoscopic lateral cartilage graft tympanoplasty. The mean age was 24.4 years (range, 6-71 years), and 22 patients (65%) were younger than 18 years...
October 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28468207/management-of-rhinophyma-outcomes-study-of-the-subunit-method
#12
Aladdin H Hassanein, Raj M Vyas, Jessica Erdmann-Sager, Edward J Caterson, Julian J Pribaz
BACKGROUND: Rhinophyma causes a nasal deformity and functional airway obstruction. Partial excision (eg, tangential) with secondary healing commonly removes hypertrophic soft tissues but does not improve nasal support. The subunit method for rhinophyma uses 6 nasal flaps to provide exposure for removal of rhinophymatous tissue and enhance structure. The purpose of this study was to evaluate outcomes of subunit method. METHODS: Medical records of patients with rhinophyma treated with the subunit method between 2013 and 2016 were analyzed...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28405749/the-anterior-commissure-of-the-human-larynx-revisited
#13
Jean Michel Prades, M Peoc'h, C Petcu, A Karkas, J M Dumollard, M Gavid
BACKGROUND: The anterior commissure (AC) of the human larynx is usually understood as an area of the glottis anteriorly situated between the two vocal folds inserting to the thyroid cartilage (TC). The pattern of spread of AC carcinoma could hypothesize that AC could include other structures of the ventral larynx as developmental anatomy could demonstrate. METHODS: Ten adult larynx specimens from donation program cadavers and 15 selected fetal specimens (from 11 to 34 weeks of amenorrhoea) were studied using microdissection and histological serial sections stained with hematoxylin-eosin and reticuline...
April 12, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28388799/dorsal-augmentation-using-autologous-costal-cartilage-or-microfat-infused-soft-tissue-augmentation
#14
Dean M Toriumi
Costal cartilage grafting is increasing in popularity with increased demand for augmentation rhinoplasty and increased need for grafting material for structure rhinoplasty techniques. Use of costal cartilage for dorsal grafting is both art and science. The art is demonstrated in the act of carving a dorsal graft that will reflect the actual contour of the nasal dorsum. The science is linked to the methodology of how the grafts are contoured to match the patient's desires and how the graft is fixed to the bony dorsum to minimize the risk of warping and displacement...
April 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/28346290/endoscopic-ear-surgery-for-external-auditory-canal-cholesteatoma
#15
Jörg Dähn, Lukas Anschuetz, Masaya Konishi, Mark Sayles, Marco Caversaccio, Patrick Dubach
BACKGROUND: Treatment of external auditory canal cholesteatoma (EACC) has been a question of debate. To our knowledge and according to a systematic review of endoscopic ear surgery (EES) in 2015, this study describes for the first time the technique and outcome by solely transcanal EES for EACC. STUDY METHOD: Retrospective case series, level of evidence IV. METHODS: Between October 2014 and December 2016, nine patients with unilateral EACC have been treated by EES...
June 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28304079/endoscope-or-microscope-guided-pediatric-tympanoplasty-comparison-of-grafting-technique-and-outcome
#16
Adrian L James
OBJECTIVES/HYPOTHESIS: To review experience from the introduction of totally endoscopic ear surgery (TEES) to a pediatric tympanoplasty practice to identify factors influencing technique selection and successful outcome. STUDY DESIGN: Prospective cohort study. METHODS: Analysis of prospectively acquired data from a consecutive series of 295 surgeries for tympanic membrane perforation over a 12-year period. Success of perforation closure was compared between microscope and TEES grafting techniques...
March 17, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28134644/management-of-rhinophyma-outcomes-study-of-the-subunit-method
#17
Aladdin H Hassanein, Raj M Vyas, Jessica Erdmann-Sager, Edward J Caterson, Julian J Pribaz
BACKGROUND: Rhinophyma causes a nasal deformity and functional airway obstruction. Partial excision (eg, tangential) with secondary healing commonly removes hypertrophic soft tissues but does not improve nasal support. The subunit method for rhinophyma uses 6 nasal flaps to provide exposure for removal of rhinophymatous tissue and enhance structure. The purpose of this study was to evaluate outcomes of subunit method. METHODS: Medical records of patients with rhinophyma treated with the subunit method between 2013 and 2016 were analyzed...
January 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28094473/transmeatal-tympanoplasty-of-subtotal-and-anterior-perforations-a-single-institution-experience-including-94-patients
#18
LETTER
E A J de Savornin Lohman, J Borgstein
No abstract text is available yet for this article.
August 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28032157/a-rare-case-of-endochondral-pseudocyst-of-the-auricle
#19
Yahya Baltu, Utku Can Dölen, Orhan Aydin
Endochondral pseudocyst of the auricle is a very rare, benign, non-inflammatory cystic lesion. It most commonly develops in the scaphoid or triangular fossa of the ear. In this case report, we present a 46-year-old man with a painless lesion on the scaphoid fossa of the right ear. We removed the hypertrophic perichondrium forming the anterior wall of the pseudocyst, curetted the ear cartilage, and dressed it with compression. No complications, such as infection, seroma, or hematoma, occurred during the postoperative period...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28027321/elevated-fibroblast-growth-factor-signaling-is-critical-for-the-pathogenesis-of-the-dwarfism-in-evc2-limbin-mutant-mice
#20
Honghao Zhang, Nobuhiro Kamiya, Takehito Tsuji, Haruko Takeda, Greg Scott, Sudha Rajderkar, Manas K Ray, Yoshiyuki Mochida, Benjamin Allen, Veronique Lefebvre, Irene H Hung, David M Ornitz, Tetsuo Kunieda, Yuji Mishina
Ellis-van Creveld (EvC) syndrome is a skeletal dysplasia, characterized by short limbs, postaxial polydactyly, and dental abnormalities. EvC syndrome is also categorized as a ciliopathy because of ciliary localization of proteins encoded by the two causative genes, EVC and EVC2 (aka LIMBIN). While recent studies demonstrated important roles for EVC/EVC2 in Hedgehog signaling, there is still little known about the pathophysiological mechanisms underlying the skeletal dysplasia features of EvC patients, and in particular why limb development is affected, but not other aspects of organogenesis that also require Hedgehog signaling...
December 2016: PLoS Genetics
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