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https://www.readbyqxmd.com/read/29053517/total-palatal-mobilization-and-multilamellar-suturing-technique-improves-outcome-for-palatal-fistula-repair
#1
Ahmed Elsherbiny, John H Grant
BACKGROUNDS: The success rate of the surgical repair of palatal fistula after palatoplasty is often unsatisfactory. This study is a review of 15 years of single surgeon's experience with the evolution of a reliable surgical technique with high success rate. METHODS: This is a retrospective chart review of consecutive cleft cases undergoing repair of palatal fistula from 2000 to 2015. The study included 37 consecutive fistula repair cases with wide elevation and mobilization of the palatal tissues and nasal and oral layer repair...
October 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29051537/microarray-gene-expression-of-periosteum-in-spontaneous-bone-regeneration-of-mandibular-segmental-defects
#2
Zheyi Li, Juli Pan, Jinling Ma, Zhen Zhang, Yuxing Bai
Spontaneous bone regeneration could occur to reestablish mandibular bony continuity in patients who underwent partial or total mandibulectomy for tumors with periosteum-preserving. However, scarce data is available related to the precise role of periosteum in this bone regeneration. Therefore we aimed to investigate the gene expression of periosteum that were involved in the mandibular bone regeneration. Mandibular segmental defects were created in six mini-pigs with periosteum preserved. The periosteum of defects and control site were harvested at 1 and 2 weeks...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29036939/female-genital-mutilation-reconstruction-a-preliminary-report
#3
Catherine S Chang, David W Low, Ivona Percec
Background: Female genital mutilation (FGM) is internationally recognized as a violation of human rights. Though rarely discussed, FGM is prevalent, affecting hundreds of millions of females worldwide. Objectives: We believe that is important for plastic surgeons to be informed and prepared to address the surgical and emotional needs of these women. We present our experience on treatment of women subjected to FGM. Methods: Three consecutive patients were treated by our clitoral restoration procedure...
September 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29024120/remodeling-and-modeling-based-bone-formation-with-teriparatide-versus-denosumab-a-longitudinal-analysis-from-baseline-to-3-months-in-the-ava-study
#4
David W Dempster, Hua Zhou, Robert R Recker, Jacques P Brown, Christopher P Recknor, E Michael Lewiecki, Paul D Miller, Sudhaker D Rao, David L Kendler, Robert Lindsay, John H Krege, Jahangir Alam, Kathleen A Taylor, Thomas E Melby, Valerie A Ruff
There has been renewed interest of late in the role of modeling-based formation (MBF) during osteoporosis therapy. Here we describe early effects of an established anabolic (teriparatide) versus antiresorptive (denosumab) agent on remodeling-based formation (RBF), MBF, and overflow MBF (oMBF) in human transiliac bone biopsies. Postmenopausal women with osteoporosis received subcutaneous teriparatide (n = 33, 20 µg/day) or denosumab (n = 36, 60 mg once/6 months), open-label for 6 months at 7 US and Canadian sites...
October 12, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29021982/autologous-periosteum-derived-micrografts-and-plga-ha-enhance-the-bone-formation-in-sinus-lift-augmentation
#5
Ruggero Rodriguez Y Baena, Riccardo D'Aquino, Antonio Graziano, Letizia Trovato, Antonio C Aloise, Gabriele Ceccarelli, Gabriella Cusella, André A Pelegrine, Saturnino M Lupi
Sinus lift augmentation is a procedure required for the placement of a dental implant, whose success can be limited by the quantity or quality of available bone. To this purpose, the first aim of the current study was to evaluate the ability of autologous periosteum-derived micrografts and Poly(lactic-co-glycolic acid) (PLGA) supplemented with hydroxyl apatite (HA) to induce bone augmentation in the sinus lift procedure. Secondly, we compared the micrograft's behavior with respect to biomaterial alone, including Bio-Oss® and PLGA/HA, commercially named Alos...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28987025/an-integrated-bioprocess-for-the-expansion-and-chondrogenic-priming-of-human-periosteum-derived-progenitor-cells-in-suspension-bioreactors
#6
Priyanka Gupta, Liesbet Geris, Frank P Luyten, Ioannis Papantoniou
The increasing use of microcarrier based suspension bioreactors for scalable expansion of adult progenitor cells in recent years reveals the necessity of such approaches to address bio manufacturing challenges of advanced therapeutic medicinal products. However, the differentiation of progenitor cells within suspension bioreactors for the production of tissue modules is of equal importance but not well investigated. This study reports on the development of a bioreactor based integrated process for expansion and chondrogenic priming of human periosteum derived stem cells (hPDCs) using Cultispher S microcarriers...
October 7, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28979605/medial-patellofemoral-ligament-reconstruction-using-the-hamstring-tendon-for-patellofemoral-joint-instability-in-an-81-year-old-female
#7
Tsuneari Takahashi, Katsushi Takeshita
INTRODUCTION: Chronic patellofemoral instability occurs mainly in adolescent females and can also be induced by medial patellofemoral ligament (MPFL) injury. There are no case reports of MPFL reconstruction for chronic patellofemoral instability due to MPFL injury in aged populations. CASE PRESENTATION: 81-year-old female presented with left knee pain, giving way, and patellar instability while climbing stairs, which continued for 18 months. Patellar apprehension test was positive, and roentgenogram showed lateral patellar subluxation...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28977118/effects-of-vacuum-sealing-drainage-on-the-treatment-of-cranial-bone-exposed-wounds-in-rabbits
#8
X J Chen, S Liu, G Z Gao, D X Yan, W S Jiang
This study was designed to assess the efficacy of vacuum sealing drainage (VSD) on skull exposure wounds in rabbits and to investigate the underlying mechanism of the process. Full-thickness excisional circular wounds 2×2 cm with or without periosteum involvement were created in 88 New Zealand white rabbits (mean body weight: 3.0±0.65 kg). Animals were randomly divided into 4 groups: periosteum-intact wounds treated with traditional dressing (p+control), periosteum-intact wounds treated with VSD (p+VSD), periosteum-lacking wounds treated with traditional dressing (p-control) and periosteum-lacking wounds treated with VSD (p-VSD)...
October 2, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28974149/proliferative-cartilaginous-lesions-in-the-calcaneal-tendons-of-hunog-mice
#9
Alexandria M MacLeod, Piper M Treuting, Cathy S Carlson
NOD/Shi-scid/IL-2Rγnull (NOG) mice are humanized with CD34+ hematopoietic cells (huNOG mice) and are commonly utilized for biological or medical research on human therapeutics. In the present study, nine 26-week-old, female huNOG mice were utilized for testing proprietary immune-modulating drugs over a 3-week period at the University of Washington. Two of the 9 mice developed unilateral swelling of a tibiotarsal joint with associated paresis of the affected limb. Full necropsies were performed after euthanasia at experimental end point, and routine tissues and affected tibiotarsal joints were evaluated...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28967360/what-can-we-learn-from-osteoarthritis-pain-in-companion-animals
#10
REVIEW
Dorothy Cimino Brown
The lack of successful translation of basic research discoveries into safe and effective treatments for chronic pain patients has led to increased scrutiny of the preclinical models used in pain research, particularly for osteoarthritis, where there is a significant disconnect between the animal models used to study the structural versus symptomatic aspects of the disease. Companion dogs offer a unique opportunity to assess osteoarthritis pain in a physiologically relevant 'model' of the disease. Approximately 20% of the canine pet population spontaneously develops osteoarthritis, translating to at least 15 million dogs in the United States alone...
September 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28966811/long-term-follow-up-for-ossification-of-autologous-bone-plug-and-skin-sinking-after-periosteum-preserved-burr-hole-surgery
#11
Hisashi Kubota, Yasuhiro Sanada, Saori Murakami, Masaharu Miyauchi, Michihiro Iwakura, Kazuhiro Nagatsuka, Kentaro Furukawa, Amami Kato, Mitsugu Fujita
BACKGROUND: The demand of a burr hole surgery for chronic subdural hematoma (CSDH) is increasing in the global aging society. Burr hole-derived autologous bone dusts are not associated with extra costs compared with other commonly used synthetic materials. In addition, postoperative calvarium ossification requires periosteum-mediated blood supply, which is lacking after using avascular synthetic materials. Based on these findings, we hypothesized that the combination of the bone plugs and the preserved periosteum during burr hole surgeries for CSDH would induce efficient calvarium ossification...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28965317/radiographic-evaluation-of-patients-with-anterior-shoulder-instability
#12
REVIEW
Andrew J Kompel, Xinning Li, Ali Guermazi, Akira M Murakami
PURPOSE OF REVIEW: Injuries to the labrum, joint capsule (in particular the inferior glenohumeral ligament), cartilage, and glenoid periosteum are associated with anterior shoulder instability. The goal of this review is to provide common radiographic images and findings in patients with anterior shoulder instability. Furthermore, we will demonstrate the best methods for measuring anterior glenoid bone loss. RECENT FINDINGS: Magnetic resonance (MR) imaging is highly relied upon for evaluating anterior shoulder instability and can diagnose soft tissue injuries with high sensitivity...
September 30, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28958630/anatomical-evidence-for-the-anterior-plate-fixation-of-sacroiliac-joint
#13
Zhibiao Bai, Shichang Gao, Jia Liu, Anlin Liang, Weihua Yu
BACKGROUND: The iatrogenic injuries to the lumbar nerves during the fixation the sacroiliac (SI) joint fractures with anterior plates were often reported. No specific method had been reported to avoid it. This study was done to find a safer way of placing the anterior plates and screws for treating the sacroiliac (SI) joint fracture and/or dislocation. METHODS: The research was performed using 8 male and 7 female normal corpse pelvic specimens preserved by 10% formalin solution...
September 25, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28956507/detection-and-characterization-of-the-accessory-mental-foramen-using-cone-beam-computed-tomography
#14
Yihan Li, Xiangwen Yang, Bichu Zhang, Bin Wei, Yao Gong
OBJECTIVE: This study aimed to investigate the frequency and characteristics of accessory mental foramina (AMFs) and their bony canals in a selected Chinese population using cone-beam computed tomography (CBCT). MATERIALS AND METHODS: Reconstructed CBCT images of the mandible in 784 Chinese patients (305 males and 479 females) were retrospectively analysed to identify the AMF. The presence, dimension and location of the AMF as well as the origin and course of the associated bony canal were evaluated and classified...
September 28, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28938322/the-relationship-of-the-temporal-branch-of-the-facial-nerve-to-the-fascial-planes-of-temporal-region-in-human-fetuses
#15
Özlem Elvan, Alev Bobuş Kara, Mesut Sabri Tezer, Mustafa Aktekin
The aim of this study was to obtain information by assessing the relationship between temporal region fascial structures, fat pads, and temporal branches of facial nerve in human fetuses to use the knowledge on treatment of early childhood period surgeries. This anatomic dissection study was conducted on 40 hemifaces with no visible external abnormalities on their faces. Fascial layers and related fat pads of temporal region were dissected layer by layer beginning from superficial to deep. The relations of temporal branches of facial nerve and temporoparietal fascia and the structures of these fascial layers were evaluated...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28925539/expression-and-functional-proteomic-analyses-of-osteocytes-from-xenopus-laevis-tested-under-mechanical-stress-conditions-preliminary-observations-on-an-appropriate-new-animal-model
#16
Jessika Bertacchini, Marta Benincasa, Marta Checchi, Francesco Cavani, Alberto Smargiassi, Marzia Ferretti, Carla Palumbo
Hitherto, the role of the osteocyte as transducer of mechanical stimuli into biological signals is far from settled. In this study, we used an appropriate model represented by the cortex of Xenopus laevis long bone diaphysis lacking (unlike the mammalian one) of vascular structures and containing only osteocytes inside the bone matrix. These structural features allow any change of protein profile that might be observed upon different experimental conditions, such as bone adaptation to stress/mechanical loading, to be ascribed specifically to osteocytes...
September 19, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28913293/facial-flap-repositioning-in-posttraumatic-facial-asymmetry
#17
Il Hwan Byun, Dahn Byun, Woo Yeol Baek
Perfect facial and body symmetry is an important aesthetic concept which is very difficult, if not impossible, to achieve. Yet, facial asymmetries are commonly encountered by plastic and reconstructive surgeons. Here, we present a case of posttraumatic facial asymmetry successfully treated with a unique concept of facial flap repositioning. A 25-year-old male patient visited our department with severe posttraumatic facial asymmetry. There was deviated nasal bone and implant to the right, and the actual facial appearance asymmetry was much more severe compared to the computed tomography, generally shifted to the right...
December 2016: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28911959/histological-changes-in-the-periosteum-following-subperiosteal-expansion-in-rabbit-scalp
#18
Mohamad Taghi Kiani, Nasrin Takzare, Ahad Khoshzaban, Elahe Jalilianfar, Leila Aghajanpour, Reza Tabrizi
PURPOSE: In intraoral bone grafting, tension-free coverage of the recipient site with periosteal flap results in optimal wound closure. Tissue expansion could be a suitable modality to obtain soft tissue in the oral cavity. The aim of this study was to assess the histology of the periosteum after subperiosteal expansion in the rabbit scalp. MATERIALS AND METHODS: In this animal study, 6 rectangular tissue expanders were placed in the skulls of 6 male white New Zealand rabbits; in 6 control rabbits, an incision was made to the periosteum but no expansion was performed...
August 31, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28889194/functions-of-periostin-in-dental-tissues-and-its-role-in-periodontal-tissues-regeneration
#19
REVIEW
Juan Du, Minqi Li
The goal of periodontal regenerative therapy is to predictably restore the tooth's supporting periodontal tissues and form a new connective tissue attachment of periodontal ligament (PDL) fibers and new alveolar bone. Periostin is a matricellular protein so named for its expression primarily in the periosteum and PDL of adult mice. Its biological functions have been widely studied in areas such as cardiovascular physiology and oncology. Despite being initially identified in the dental tissues and bone, investigations of Periostin functions in PDL and alveolar-bone-related physiopathology are less abundant...
September 9, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28888067/injectable-thermosensitive-alginate-%C3%AE-tricalcium-phosphate-aspirin-hydrogels-for-bone-augmentation
#20
Xiaoqian Fang, Lei Lei, Ting Jiang, Ying Chen, Yunqing Kang
In this study, an injectable and thermo-sensitive alginate/β-tricalcium phosphate hydrogel (TSAH/β-TCP) was prepared for aspirin release to a bone defect. Aspirin was dissolved into a mixture of poly(N-isopropylacrylamide) (PNIPAAm), an aminated alginate-g-PNIPAAm co-polymer, and β-TCP powders. Scanning electron microscopy showed that TSAH/β-TCP had an interconnected porous microstructure with a porosity of 86.78%. The cross-linked hydrogel released approximately 40% of the aspirin in the first 3 days and then slowly released the remainder...
September 9, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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