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https://www.readbyqxmd.com/read/29626696/fine-tuning-pro-angiogenic-effects-of-cobalt-for-simultaneous-enhancement-of-vascular-endothelial-growth-factor-secretion-and-implant-neovascularization
#1
Yoke Chin Chai, Luis Freitas Mendes, Nick van Gastel, Geert Carmeliet, Frank P Luyten
Rapid neovascularization of a tissue-engineered (TE) construct by the host vasculature is quintessential to warrant effective bone regeneration. This process can be promoted through active induction of angiogenic growth factor secretion or by implementation of in vitro pre-vascularization strategies. In this study, we aimed at optimizing the pro-angiogenic effect of Cobalt (Co2+ ) to enhance vascular endothelial growth factor (VEGF) expression by human periosteum-derived mesenchymal stem cells (hPDCs). Simultaneously we set out to promote microvascular network formation by co-culturing with human umbilical vein endothelial cells (HUVECs)...
April 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29580181/decellularised-cartilage-directs-chondrogenic-differentiation-creation-of-a-fracture-callus-mimetic
#2
Wollis Jude Vas, Mittal Shah, Thomas Stephen Blacker, Michael Roland Duchen, Paul Sibbons, Scott John Roberts
Complications that arise from impaired fracture healing have considerable socioeconomic implications. Current research in the field of bone tissue engineering predominantly aims to mimic the mature bone tissue microenvironment. This approach, however, may produce implants that are intrinsically unresponsive to the cues present during the initiation of fracture repair. As such, this study describes the development of decellularised xenogeneic hyaline cartilage matrix in an attempt to mimic the initial reparative phase of fracture repair...
March 27, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29553545/construction-and-evaluation-of-a-murine-calvarial-osteolysis-model-by-exposure-to-cocrmo-particles-in-aseptic-loosening
#3
Hui Jiang, Yicun Wang, Zhantao Deng, Jiewen Jin, Jia Meng, Shuo Chen, Jun Wang, Yang Qiu, Ting Guo, Jianning Zhao
Wear particle-induced osteolysis is a major cause of aseptic loosening in arthroplasty failure, but the underlying mechanism remains unclear. Due to long follow-ups necessary for detection and sporadic occurrence, it is challenging to assess the pathogenesis ofparticle-induced osteolysis in clinical cases. Hence, optimal animal models are required for further studies. The murine model of calvarial osteolysis established by exposure to CoCrMo particles is an effective and valid tool for assessing the interactions between particles and various cells in aseptic loosening...
February 17, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29543679/repair-of-large-full-thickness-scalp-defects-using-biomaterial-and-skin-grafting
#4
Sheng Yan, Hangyan Shi, Da Chen, Jincai Guo, Yi Sun, Sufan Wu
The reconstruction of large full-thickness scalp defects remains a surgical challenge, especially when the skull is exposed completely without periosteum. Surgical technique options for wound coverage have included tissue expansion, skin grafting, local or regional flaps, and microvascular free tissue transfer. In recent years, some authors have reported to use biological material as an alternative for repairing complex wounds. The authors report the successful reconstruction of a large defect with bare skull in bilateral temporal regions of a 3-year-old child...
March 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29534117/a-three-stage-split-crest-technique-case-series-of-horizontal-ridge-augmentation-in-the-atrophic-posterior-mandible
#5
Guei-Hua Hu, Stuart J Froum, Abdullah Alodadi, Fuyuki Nose, Yung-Cheng Paul Yu, Takanori Suzuki, Sang-Choon Cho
This paper introduces a three-stage split-crest (TSSC) technique for horizontal ridge augmentation in the atrophic posterior mandible. The first stage consists of splitting the ridge. Following a 3- to 4-week healing interval, the second stage consists of expansion of the cortical plate (without elevating the periosteum) and placement of a bone replacement graft material. After 3 to 4 months of healing, the implants are placed. The advantages of this three-stage technique are increased vascularization to the surgical area, a decrease in procedure complications, and improved implant survival rates...
March 13, 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29533678/autologous-chondrocyte-implantation-for-bipolar-chondral-lesions-in-the-tibiofemoral-compartment
#6
Takahiro Ogura, Tim Bryant, Brian A Mosier, Tom Minas
BACKGROUND: Treating bipolar chondral lesions in the tibiofemoral (TF) compartment with cartilage repair procedures is challenging, and a suitable treatment remains unclear. PURPOSE: To evaluate clinical outcomes after autologous chondrocyte implantation (ACI) for the treatment of bipolar chondral lesions in the TF compartment. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: We evaluated 57 patients who underwent ACI for the treatment of symptomatic bipolar chondral lesions in the TF compartment by a single surgeon between October 1995 and June 2014...
March 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29524678/the-periosteum-like-effect-of-fresh-human-amniotic-membrane-on-bone-regeneration-in-a-rabbit-critical-sized-defect-model
#7
Sahar Ghanmi, Moez Trigui, Walid Baya, Zoubaier Ellouz, Abdelfatteh Elfeki, Slim Charfi, Jean Christophe Fricain, Hassib Keskes
OBJECTIVE: The purpose of this study was to investigate the effect of fresh human amniotic membrane (FHAM) as a substitute of periosteum to enhance bone regeneration in critical-sized defects. METHODS: Tibial diaphyseal bone defects were created in forty New Zealand white rabbits and treated with FHAM or left empty. Treatment groups consisted of: FHAM implanted in the place of removed periosteum (FHAMP group); FHFAM implanted to fill the entire defect (FHAMF group) compared to negative control group; empty defect with removing the periosteum (NC group) and positive control group; and empty defect without removing the periosteum (PC group)...
March 7, 2018: Bone
https://www.readbyqxmd.com/read/29523188/azoramide-a-novel-regulator-favors-adipogenesis-against-osteogenesis-through-inhibiting-the-glp-1-receptor-pka-%C3%AE-catenin-pathway
#8
Banjun Ruan, Zheng Zhu, Zhao Yan, Wei Yang, Dongsheng Zhai, Li Wang, Zichen Ye, Huanyu Lu, An Xiang, Jingwei Liang, Yinghao Jiang, Chengming Xu, Zhenyu Wang, Ming Wei, Xiaoying Lei, Xiaorui Cao, Zifan Lu
BACKGROUND: The reciprocal fate decision of mesenchymal stem cells (MSCs) to either bone or adipocytes is determined by Wnt-related signaling and the glucagon-like peptide-1 receptor (GLP-1R). Azoramide, an ER stress alleviator, was reported to have an antidiabetic effect. In this study, we investigated the function of azoramide in regulating the lineage determination of MSCs for either adipogenic or osteogenic differentiation. METHODS: In this study, microcomputed tomography and histological analysis on bone morphogenetic protein (BMP)2-induced parietal periosteum bone formation assays, C3H10T1/2 and mouse bone marrow MSC-derived bone formation and adipogenesis assays, and specific staining for bone tissue and lipid droplets were used to evaluate the role of azoramide on the lineage determination of MSC differentiation...
March 9, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29519996/sterile-bronchopleural-fistula-following-surgical-removal-of-primary-lung-leiomyoma-inducing-secondary-hypertrophic-osteoarthropathy
#9
Abdulhadi A AlAmodi, Mohamad H Farhoud, Najwa Mohammad, Rawan Alatassi, Dana Alolayet, Noor AlQeshtaini, Raghad AlMamlouk, Mohamed Hussein Ahmed, Mahmoud Ashour, Sara S Kayyali, Abdullah AlShammari
BACKGROUND Leiomyomas are benign neoplasms of the smooth muscle. When found in the pulmonary system, a rare occurrence, leiomyomas can result in hypertrophic osteoarthropathy, or significant clubbing, associated with proliferation of long bone periosteum. Bronchopulmonary fistulas, or communications between the bronchial tree and pleural space, are an uncommon postoperative complication of pneumonectomies. Even more infrequent is the presence of a bronchopulmonary fistula that is determined to be sterile. CASE REPORT The patient presented in the current case report is a 40-year-old previously healthy woman who presented with a 5-year history of chronic cough, right-sided chest discomfort, and dyspnea associated with back pain, and lower leg pain...
March 9, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29513769/cortical-bone-repositioning-technique-for-horizontal-alveolar-bone-augmentation-a-case-series
#10
Kensuke Yamauchi, Shinnosuke Nogami, Yoshihiro Kataoka, Shigeto Koyama, Bernd Lethaus, Tetsu Takahashi
The objective of this study was to present a novel procedure for cortical bone repositioning (CBR) that maintains a secure space under the periosteum by replacement of the lateral cortex via fixation, employing titanium screws. Seven systemically healthy patients presenting with horizontal alveolar bone defects in radiographs and CT images were enrolled for CBR technique for horizontal alveolar bone augmentation. A lateral cortical bone block was cut in the defects and freed from the original bony surface. A screw was inserted into the block, and the block was placed laterally to allow fixation...
March 7, 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29497100/intramembranous-ossification-and-endochondral-ossification-are-impaired-differently-between-glucocorticoid-induced-osteoporosis-and-estrogen-deficiency-induced-osteoporosis
#11
Hongyang Zhang, Xiaojuan Shi, Long Wang, Xiaojie Li, Chao Zheng, Bo Gao, Xiaolong Xu, Xisheng Lin, Jinpeng Wang, Yangjing Lin, Jun Shi, Qiang Huang, Zhuojing Luo, Liu Yang
A fracture is the most dangerous complication of osteoporosis in patients because the associated disability and mortality rates are high. Osteoporosis impairs fracture healing and prognosis, but how intramembranous ossification (IO) or endochondral ossification (EO) during fracture healing are affected and whether these two kinds of ossification are different between glucocorticoid-induced osteoporosis (GIOP) and estrogen deficiency-induced osteoporosis (EDOP) are poorly understood. In this study, we established two bone repair models that exhibited repair via IO or EO and compared the pathological progress of each under GIOP and EDOP...
March 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29485295/-five-layer-gasket-seal-watertight-closure-for-reconstruction-of-the-skull-base-in-complex-bilateral-traumatic-intraorbital-meningoencephaloceles-a-case-report-and-literature-review
#12
Dan Zhao, Shanwei Tao, Dewei Zhang, Mengyang Qin, Yijun Bao, Anhua Wu
PURPOSE: Traumatic meningoencephalocele primarily occurs as a rare but complex complication of cranial base and orbital roof fractures. Traumatic intraorbital meningoencephalocele, which is rare and easily overlooked, can be life-threatening since cephalomeningitis occurs due to cerebrospinal fluid (CSF) leakage. It is obscure for the operative indications or standard surgical methods of traumatic meningoencephaloceles since the combined intricate craniofacial and basal fractures, brain injury, and CSF leak may exist...
February 27, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29479711/a-novel-role-for-cathepsin-k-in-periosteal-osteoclast-precursors-during-fracture-repair
#13
Bhavita Walia, Elizabeth Lingenheld, Le Duong, Archana Sanjay, Hicham Drissi
Osteoporosis management is currently centered around bisphosphonates, which inhibit osteoclast (OC) bone resorption but do not affect bone formation. This reduces fracture risk, but fails to restore healthy bone remodeling. Studies in animal models showed that cathepsin K (CatK) inhibition by genetic deletion or chemical inhibitors maintained bone formation while abrogating resorption during bone remodeling and stimulated periosteal bone modeling. Recently, periosteal mononuclear tartrate-resistant acid phosphatase-positive (TRAP+ ) osteoclast precursors (OCPs) were shown to augment angiogenesis-coupled osteogenesis...
February 26, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29473324/establishment-and-characterization-of-in-vivo-orthotopic-bioluminescent-xenograft-models-from-human-osteosarcoma-cell-lines-in-swiss-nude-and-nsg-mice
#14
Maria Eugenia Marques da Costa, Estelle Daudigeos-Dubus, Anne Gomez-Brouchet, Olivia Bawa, Valerie Rouffiac, Massimo Serra, Katia Scotlandi, Conceição Santos, Birgit Geoerger, Nathalie Gaspar
Osteosarcoma is one of the most common primary bone tumors in childhood and adolescence. Metastases occurrence at diagnosis or during disease evolution is the main therapeutic challenge. New drug evaluation to improve patient survival requires the development of various preclinical models mimicking at best the complexity of the disease and its metastatic potential. We describe here the development and characteristics of two orthotopic bioluminescent (Luc/mKate2) cell-derived xenograft (CDX) models, Saos-2-B-Luc/mKate2-CDX and HOS-Luc/mKate2-CDX, in different immune (nude and NSG mouse strains) and bone (intratibial and paratibial with periosteum activation) contexts...
February 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29472541/periosteum-contains-skeletal-stem-cells-with-high-bone-regenerative-potential-controlled-by-periostin
#15
Oriane Duchamp de Lageneste, Anaïs Julien, Rana Abou-Khalil, Giulia Frangi, Caroline Carvalho, Nicolas Cagnard, Corinne Cordier, Simon J Conway, Céline Colnot
Bone regeneration relies on the activation of skeletal stem cells (SSCs) that still remain poorly characterized. Here, we show that periosteum contains SSCs with high bone regenerative potential compared to bone marrow stromal cells/skeletal stem cells (BMSCs) in mice. Although periosteal cells (PCs) and BMSCs are derived from a common embryonic mesenchymal lineage, postnatally PCs exhibit greater clonogenicity, growth and differentiation capacity than BMSCs. During bone repair, PCs can efficiently contribute to cartilage and bone, and integrate long-term after transplantation...
February 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29467016/advancing-osteochondral-tissue-engineering-bone-morphogenetic-protein-transforming-growth-factor-and-fibroblast-growth-factor-signaling-drive-ordered-differentiation-of-periosteal-cells-resulting-in-stable-cartilage-and-bone-formation-in-vivo
#16
L F Mendes, H Katagiri, W L Tam, Y C Chai, L Geris, S J Roberts, F P Luyten
BACKGROUND: Chondrogenic mesenchymal stem cells (MSCs) have not yet been used to address the clinical demands of large osteochondral joint surface defects. In this study, self-assembling tissue intermediates (TIs) derived from human periosteum-derived stem/progenitor cells (hPDCs) were generated and validated for stable cartilage formation in vivo using two different animal models. METHODS: hPDCs were aggregated and cultured in the presence of a novel growth factor (GF) cocktail comprising of transforming growth factor (TGF)-β1, bone morphogenetic protein (BMP)2, growth differentiation factor (GDF)5, BMP6, and fibroblast growth factor (FGF)2...
February 21, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29465436/orbital-exenteration-for-sinonasal-malignancies-indications-rehabilitation-and-oncologic-outcomes
#17
José G Vartanian, Ronaldo N Toledo, Thiago Bueno, Luiz P Kowalski
PURPOSE OF REVIEW: Review the recent literature regarding the management of orbital invasion in sinonasal malignant tumors. RECENT FINDINGS: There is a recent trend in preserving the orbit in cases of minimal invasion of periosteum and limited periorbit involvement, as well as in presence of good response to neoadjuvant chemotherapy, mainly in squamous cell carcinoma and neuroendocrine histologies. SUMMARY: The decision about orbital exenteration in cases of sinonasal malignancies is facilitated if the patient already has clear clinical signs of intraconal invasion such as visual loss, restriction of ocular mobility or infiltration of the eyeglobe...
April 2018: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29461245/-immunomorphological-aspects-of-bacterial-sensitization-in-the-experiment
#18
A Taganiyazova, G Sultanova, M Kurmanalina, G Isaeva, A Ramankulova
This study investigates the morphological structure of lungs, liver and kidneys of the experimental animals. To reproduce the inflammation in maxilla-facial region under the periosteum of guinea pigs' mandible a suspension of S.aureus was inoculated. The infected site was exposed by a constant electric current of positive polarity of 5-10 μA strength. Allergotests were used to determine the level of sensitization. Structural changes in the organs were determined by microscopic examination. The results of the study showed that as the contact with the antigen increased, the number of positive allergic tests also increased...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29456311/management-of-fenestration-using-bone-allograft-in-conjunction-with-platelet-rich-fibrin
#19
Anuradha Bhatsange, Alkesh Shende, Sabina Deshmukh, Sharanabasappa Japatti
Fenestration and dehiscence are said to be anatomical variations of cortical bone and not true pathological entities. They represent window-like defects covered by periosteum and overlying gingiva with or without the intact marginal bone. The etiology of such defects is still unclear, though many hypotheses such as occlusal traumatism, trauma, and variation in root bone angulation have been put forward. Diagnosis of such defects is challenging clinically, and they cannot be appreciated in conventional radiographs...
July 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29441226/plexiform-neurofibroma-in-the-axilla-with-intraosseous-neurofibroma-in-the-humerus-in-neurofibromatosis-5
#20
Sanjay Mhalasakant Khaladkar, Surbhi Chauhan, Raghav Kalra, Shishir Chauhan
Segmental neurofibromatosis type 5 (NF5) is a rare form of NF, in which the cutaneous and/or neural changes are confined to one region of the body. It is often underdiagnosed or undetected due to the absence of symptoms. Inheritance of NF is different from other types of NF. Intraosseous neurofibromas are rare tumors which develop from nerves supplying the periosteum or nerves following the intraosseous course. Plexiform neurofibroma with associated intraosseous neurofibroma is extremely rare. We report a case of plexiform neurofibroma in the left axilla of a 17-year-old female with associated intraosseous neurofibroma in adjoining left humerus...
2018: Journal of Clinical Imaging Science
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