keyword
MENU ▼
Read by QxMD icon Read
search

periosteum

keyword
https://www.readbyqxmd.com/read/27892493/autologous-temporomandibular-joint-reconstruction-independent-of-exogenous-additives-a-proof-of-concept-study-for-guided-self-generation
#1
Jiao Wei, Tanja Herrler, Dong Han, Kai Liu, Rulin Huang, Markus Guba, Chuanchang Dai, Qingfeng Li
Joint defects are complex and difficult to reconstruct. By exploiting the body's own regenerative capacity, we aimed to individually generate anatomically precise neo-tissue constructs for autologous joint reconstruction without using any exogenous additives. In a goat model, CT scans of the mandibular condyle including articular surface and a large portion of the ascending ramus were processed using computer-aided design and manufacturing. A corresponding hydroxylapatite negative mold was printed in 3D and temporarily embedded into the transition zone of costal periosteum and perichondrium...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27889558/the-periosteal-microcirculation-in-health-and-disease-an-update-on-clinical-significance
#2
REVIEW
Andrea Szabó, Ágnes Janovszky, Levente Pócs, Mihály Boros
Apart from its nutritive functions, the periosteum critically affects bone regeneration via its stem/osteoprogenitor cell content. Normal healing after bone fractures, trauma-orthopedic interventions and invasive dental procedures is critically linked to the reestablishment of the periosteal microcirculation, but the reconstruction, replacement or repair of lost tissues may also be performed with autologous periosteum. Besides the initiation of cell differentiation during bone repair and remodeling processes, the periosteum together with the endosteum plays significant roles in the pathogenesis of both hormone-related and trauma-induced osteoporotic alterations in the bone metabolism...
November 23, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27884787/loss-of-cbl-pi3k-interaction-modulates-the-periosteal-response-to-fracture-by-enhancing-osteogenic-commitment-and-differentiation
#3
Vanessa Scanlon, Bhavita Walia, Jungeun Yu, Marc Hansen, Hicham Drissi, Peter Maye, Archana Sanjay
The periosteum contains multipotent skeletal progenitors that contribute to bone repair. The signaling pathways regulating the response of periosteal cells to fracture are largely unknown. Phosphatidylinositol-3 Kinase (PI3K), a prominent lipid kinase, is a major signaling protein downstream of several factors that regulate osteoblast differentiation. Cbl is an E3 ubiquitin ligase and a major adaptor protein that binds to the p85 regulatory subunit and modulates PI3K activity. Substitution of tyrosine 737 to phenylalanine (Y737F) in Cbl abolishes the interaction between Cbl and p85 subunit without affecting the Cbl's ubiquitin ligase function...
November 22, 2016: Bone
https://www.readbyqxmd.com/read/27882147/molecular-profiling-of-a-simple-rat-model-of-open-tibial-fractures-with-hematoma-and-periosteum-disruption
#4
Jose Rafael Villafan-Bernal, Lorenzo Franco-De La Torre, Ana Soledad Sandoval-Rodriguez, Juan Armendariz-Borunda, Juan Luis Alcala-Zermeno, Jose Alfonso Cruz-Ramos, Gabriela Lopez-Armas, Blanca Estela Ramirez-Bastidas, Gracia Viviana González-Enríquez, Emerson Armando Collazo-Guzman, Raigam Jafet Martinez-Portilla, Sergio Sánchez-Enríquez
Bone fractures are a worldwide public health concern. Therefore, improving understanding of the bone healing process at a molecular level, which could lead to the discovery of potential therapeutic targets, is important. In the present study, a model of open tibial fractures with hematoma disruption, periosteal rupture and internal fixation in 6-month-old male Wistar rats was established, in order to identify expression patterns of key genes and their protein products throughout the bone healing process. A tibial shaft fracture was produced using the three-point bending technique, the hematoma was drained through a 4-mm incision on the medial aspect of the tibia and the fracture stabilized by inserting a needle into the medullary canal...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27877072/cultured-human-periosteum-derived-cells-can-differentiate-into-osteoblasts-in-a-perioxisome-proliferator-activated-receptor-gamma-mediated-fashion-via-bone-morphogenetic-protein-signaling
#5
Jin-Eun Chung, Jin-Ho Park, Jeong-Won Yun, Young-Hoon Kang, Bong-Wook Park, Sun-Chul Hwang, Yeong-Cheol Cho, Iel-Yong Sung, Dong Kyun Woo, June-Ho Byun
The differentiation of mesenchymal stem cells towards an osteoblastic fate depends on numerous signaling pathways, including activation of bone morphogenetic protein (BMP) signaling components. Commitment to osteogenesis is associated with activation of osteoblast-related signal transduction, whereas inactivation of this signal transduction favors adipogenesis. BMP signaling also has a critical role in the processes by which mesenchymal stem cells undergo commitment to the adipocyte lineage. In our previous study, we demonstrated that an agonist of the perioxisome proliferator-activated receptor γ (PPARγ), a master regulator of adipocyte differentiation, stimulates osteoblastic differentiation of cultured human periosteum-derived cells...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27874253/combined-delivery-of-fgf-2-tgf-%C3%AE-1-and-adipose-derived-stem-cells-from-an-engineered-periosteum-to-a-critical-sized-mouse-femur-defect
#6
Raimundo Romero, John K Travers, Emilie Asbury, Attie Pennybaker, Laura Chubb, Ruth Rose, Nicole P Ehrhart, Matt J Kipper
Critical-sized long bone defects suffer from complications including impaired healing and non-union due to substandard healing and integration of devitalized bone allograft. Removal of the periosteum contributes to the limited healing of bone allografts. Restoring a periosteum on bone allografts may provide improved allograft healing and integration. This article reports a polysaccharide-based tissue engineered periosteum that delivers basic fibroblast growth factor (FGF-2), transforming growth factor-β1 (TGF-β1), and adipose-derived mesenchymal stem cells (ASCs) to a critical-sized mouse femur defect...
November 22, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27870350/the-periosteum-of-the-zygomatic-arch-vascularization-and-growth
#7
Susan W Herring, Pannee Ochareon
In addition to conveying the forces of attaching muscles and ligaments to the zygomatic and temporal bones, the arch periosteum is responsible for lateral apposition and medial resorption during the growth period. In this contribution, we describe the vasculature of the zygomatic arch in young pigs (Sus scrofa dom.) in order to understand the relationship of osseous and periosteal vessels to each other, to surrounding tissues, and to patterns of modeling. Subjects 2-6 weeks of age were perfused with vascular fill; some also received the vital bone label calcein...
December 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27870342/the-mobility-of-the-human-face-more-than-just-the-musculature
#8
Anne M Burrows, Carolyn R Rogers-Vizena, Ly Li, Bryan Mendelson
The human face has the greatest mobility and facial display repertoire among all primates. However, the variables that account for this are not clear. Humans and other anthropoids have remarkably similar mimetic musculature. This suggests that differences among the mimetic muscles alone may not account for the increased mobility and facial display repertoire seen in humans. Furthermore, anthropoids themselves outpace prosimians in these categories: humans > other anthropoids > prosimians. This study was undertaken to clarify the morphological underpinnings of the increased mobility and display repertoire of the human face by investigating the SMAS (the superficial musculo-aponeurotic system), a connective tissue layer enclosing the mimetic musculature located between the skin and deep fascia/periosteum...
December 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27867499/lessons-on-skeletal-cell-plasticity-from-studying-jawbone-regeneration-in-zebrafish
#9
REVIEW
Sandeep Paul, J Gage Crump
Three major mesenchymal cell types have important roles in determining the shapes of vertebrate animals: bone-producing osteoblasts, cartilage-producing chondrocytes, and fat-producing adipocytes. Although often considered discrete cell types, accumulating evidence is revealing mesenchymal cells of intermediate identities and interconversion of cell types. Such plasticity is particularly evident during adult skeletal repair. In this Review, we highlight recent work in zebrafish showing a role for hybrid cartilage-bone cells in large-scale regeneration of the adult jawbone, as well as their origins in the periosteum...
2016: BoneKEy Reports
https://www.readbyqxmd.com/read/27853243/axin2-expressing-cells-execute-regeneration-after-skeletal-injury
#10
R C Ransom, D J Hunter, S Hyman, G Singh, S C Ransom, E Z Shen, K C Perez, M Gillette, J Li, B Liu, J B Brunski, J A Helms
The mammalian skeleton performs a diverse range of vital functions, requiring mechanisms of regeneration that restore functional skeletal cell populations after injury. We hypothesized that the Wnt pathway specifies distinct functional subsets of skeletal cell types, and that lineage tracing of Wnt-responding cells (WRCs) using the Axin2 gene in mice identifies a population of long-lived skeletal cells on the periosteum of long bone. Ablation of these WRCs disrupts healing after injury, and three-dimensional finite element modeling of the regenerate delineates their essential role in functional bone regeneration...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27848194/intramedullary-lengthening-nails-can-we-also-correct-deformities
#11
REVIEW
U Lenze, A H Krieg
Unlike external fixators, the use of solid intramedullary lengthening nails is restricted to defined anatomical preconditions, such as an adequate bone length. Furthermore, all deformity corrections except the lengthening procedure have to be implemented intraoperatively and cannot be adjusted postoperatively. Conversely, even complex deformity corrections can be performed using intramedullary devices after a thorough preoperative planning. For preparation of the intramedullary cavity as well as positioning of the lengthening nail according to the preoperative planning, reaming the medullary canal with rigid reamers which don't follow the line of least resistance is inevitable...
November 15, 2016: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/27837171/preventing-painful-age-related-bone-fractures-anti-sclerostin-therapy-builds-cortical-bone-and-increases-the-proliferation-of-osteogenic-cells-in-the-periosteum-of-the-geriatric-mouse-femur
#12
Michelle L Thompson, Stephane R Chartier, Stefanie A Mitchell, Patrick W Mantyh
Age-related bone fractures are usually painful and have highly negative effects on a geriatric patient's functional status, quality of life, and survival. Currently, there are few analgesic therapies that fully control bone fracture pain in the elderly without significant unwanted side effects. However, another way of controlling age-related fracture pain would be to preemptively administer an osteo-anabolic agent to geriatric patients with high risk of fracture, so as to build new cortical bone and prevent the fracture from occurring...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27833287/precise-breast-implant-placement-using-percutaneous-chest-wall-markings
#13
Janna Joethy, Bien-Keem Tan
BACKGROUND: Traditionally, pre-operative breast markings are usually made using an indelible marker. These markings are at risk of being removed by pre-operative cleaning, positional changes and parenchymal changes post-incision. We present our approach to breast surgery with rib or intercostal markings using methylene blue. METHODS: Using an indelible marker, markings are made on the breast and the inframammary crease. A blue needle (23 G) mounted on a 1 ml syringe is prepared, and aliquots of 0...
May 2016: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
https://www.readbyqxmd.com/read/27819848/morphological-evaluation-of-soft-tissue-augmentation-using-porous-poly-dl-lactic-acid-with-straight-holes
#14
Yukawa Ken, Tachikawa Noriko, Akiko Furuichi, Kasugai Shohei
OBJECTIVES: This study investigated the biological reaction to porous poly-DL-lactic acid (PDLLA) scaffolds with holes for soft tissue augmentation. MATERIALS AND METHODS: The control group was porous PDLLA with a diameter of 5.0 mm and a height of 2.0 mm. For the 2 test groups, 7 holes were drilled from the upper to the lower base of the scaffolds; the holes had diameters of 0.5 and 1.0 mm. A scaffold was placed in the periosteum of the cranium. The height and molecular weight (Mw) of the scaffolds were measured at 4 and 8 weeks...
December 2016: Implant Dentistry
https://www.readbyqxmd.com/read/27808102/bioinspired-seeding-of-biomaterials-using-three-dimensional-microtissues-induces-chondrogenic-stem-cell-differentiation-and-cartilage-formation-under-growth-factor-free-conditions
#15
J Leijten, L S Moreira Teixeira, J Bolander, W Ji, B Vanspauwen, J Lammertyn, J Schrooten, F P Luyten
Cell laden biomaterials are archetypically seeded with individual cells and steered into the desired behavior using exogenous stimuli to control growth and differentiation. In contrast, direct cell-cell contact is instructive and even essential for natural tissue formation. Namely, microaggregation and condensation of mesenchymal progenitor cells triggers chondrogenesis and thereby drives limb formation. Yet a biomimetic strategy translating this approach into a cell laden biomaterial-based therapy has remained largely unexplored...
November 3, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27806676/the-role-of-cell-seeding-bio-scaffolds-and-the-in-vivo-microenvironment-in-the-guided-generation-of-osteochondral-composite-tissue
#16
Jiao Wei, Tanja Herrler, Kai Liu, Dong Han, Mei Yang, Chuanchang Dai, Qing Feng Li
Tissue engineering based on cell seeding, bio-scaffolds, and growth factors has been widely applied for the reconstruction of tissue defects. Recent progress has fueled in vivo tissue engineering techniques in becoming hot topics in regenerative medicine and reconstructive surgery. To improve the efficacy of tissue engineering, we here investigated the roles of cell seeding, bio-scaffolds, growth factors, and in-vivo microenvironment in tissue regeneration. Bone marrow derived stem cells (BMSCs), allogenic demineralized bone matrix (DBM) as bio-scaffold, and growth factors bone morphogenetic protein 2/ transforming growth factor (BMP-2/TGF-β1), and the in-vivo microenvironment of rib periosteum and perichondrium were used in different combinations for the generation of osteochondral composite tissue...
November 2, 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27804946/-parosteal-osseous-lipoma-of-the-temporal-bone-concurrent-with-involvement-of-the-parotid-salivary-gland
#17
O V Dolzhansky, E M Pal'tseva, D V Bulanov, D N Fedorov
The paper describes a case of parosteal lipoma of the temporal bone, by simultaneously involving the parotid salivary gland. Computed tomography performed in a 48-year-old man showed that in the area of the posterior edge of the glenoid fossa of the right temporal bone there was a massive (1.5×1.7×0.9-cm) exostosis extending down from the skull base. The exostosis was surrounded by a 3.5×3.6×5.3 soft tissue mass that was located in the projection of the right parotid salivary gland with a capsule and minor calcifications...
2016: Arkhiv Patologii
https://www.readbyqxmd.com/read/27798714/patellar-sleeve-fracture-with-ossification-of-the-patellar-tendon
#18
Derek S Damrow, Scott E Van Valin
Patellar sleeve fractures make up greater than 50% of all patellar fractures. They are essentially only seen in the pediatric population because of the thick periosteum and the distal patellar pole apophysis in this group. These fractures can lead to complications if not treated appropriately and in a timely fashion. Complications of missed or untreated patellar sleeve fractures include patella alta, anterior knee pain, and quadriceps atrophy. These can all result in severe limitations in activity. The authors describe a case of a 16-year-old boy who sustained a patellar sleeve fracture 3 years prior to presentation...
October 31, 2016: Orthopedics
https://www.readbyqxmd.com/read/27792145/itraq-based-quantitative-proteomic-analysis-of-the-potentiated-and-dormant-antler-stem-cells
#19
Zhen Dong, Hengxing Ba, Wei Zhang, Dawn Coates, Chunyi Li
As the only known organ that can completely regenerate in mammals, deer antler is of real significance in the field of regenerative medicine. Recent studies have shown that the regenerative capacity of the antlers comes from the pedicle periosteum and the cells resident in the periosteum possess the attributes of stem cells. Currently, the molecular mechanism of antler regeneration remains unclear. In the present study, we compared the potentiated and dormant antler stem cells using isobaric tags for the relative and absolute quantification (iTRAQ) labeling of the peptides, coupled with two-dimensional liquid chromatography-tandem mass spectrometry (LC-MS/MS) to compare the proteome profiles...
October 25, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27788928/primary-reattachment-of-avulsed-skin-flaps-with-negative-pressure-wound-therapy-in-degloving-injuries-of-the-lower-extremity
#20
G Sakai, T Suzuki, T Hishikawa, Y Shirai, T Kurozumi, M Shindo
Large avulsed skin flaps of the lower extremity caused by degloving injuries eventually develop skin necrosis in most cases. The current treatment option involves excision of the degloved skin and reapplication as a full- or split-thickness skin graft. We considered that reattachment of avulsed skin flaps without excision would be theoretically beneficial, since some circulation may remain around the connected pedicle and thus facilitate graft take. Furthermore, securing the skin to the original anatomic position is much easier using retained landmarks...
October 22, 2016: Injury
keyword
keyword
72674
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"