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https://www.readbyqxmd.com/read/29156978/bone-marrow-progenitor-cells-isolated-from-young-rabbit-trochlea-are-more-numerous-and-exhibit-greater-clonogenic-chondrogenic-and-osteogenic-potential-than-cells-isolated-from-condyles
#1
Garima Dwivedi, Anik Chevrier, Caroline D Hoemann, Michael D Buschmann
OBJECTIVE: Bone marrow stimulation procedures initiate repair by fracturing or drilling subchondral bone at base of cartilaginous defect. Earlier studies have shown that defect location and animal age affect cartilage repair outcome, suggesting a strong influence of structural and biological characteristics of subchondral bone. Here, we analyzed comprehensive biological characteristics of bone marrow progenitor cells (BMPCs) in subchondral bone of young and old rabbit condyle and trochlea...
January 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29146511/surgical-management-of-proximal-interphalangeal-joint-repetitive-stress-epiphyseal-fracture-nonunion-in-elite-sport-climbers
#2
Yasser El-Sheikh, Chris Lutter, Isabelle Schoeffl, Volker Schoeffl, Sascha Flohe
Repetitive stress fracture of the middle phalanx epiphysis is an injury specific to elite adolescent sport climbers. As sport climbing becomes increasingly popular in younger age groups, an increased number of these injuries have been reported in recent years. To date, treatment of these fractures has been nonsurgical, with strict rest and physiotherapy prescribed until fracture union. However, when these patients present in a delayed fashion with an established nonunion, nonsurgical treatment may fail, leading to disabling chronic pain and/or digital deformity in some cases...
November 14, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29145110/traumatic-separation-of-osseous-segments-in-a-double-layered-patella
#3
Andreas Jørgensen, Erik Brandt, Anton Ulstrup
INTRODUCTION: Double-layered patella is a rare intra-articular disorder associated with multiple epiphyseal dysplasia. PRESENTATION OF CASE: We present a case of a 40-year old man with acute pain in his left knee after a tackle during soccer play. DISCUSSION: Clinical examination and radiographs confirmed the diagnosis of a bilateral double-layered patella with traumatic separation of the osseous segments on the afflicted left side. Surgical management comprised of open arthrotomy and debridement of the bony interface...
November 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29137619/percutaneous-medial-hemi-epiphysiodesis-using-a-transphyseal-screw-for-caput-valgum-associated-with-developmental-dysplasia-of-the-hip
#4
Chang Ho Shin, Wan Kee Hong, Doo Jae Lee, Won Joon Yoo, In Ho Choi, Tae-Joon Cho
BACKGROUND: The purpose of this study was to evaluate the radiologic outcome of percutaneous medial hemi-epiphysiodesis using a transphyseal screw for the management of caput valgum associated with developmental dysplasia of the hip (DDH). METHODS: Eighteen hips (18 patients) having caput valgum treated with screw hemi-epiphysiodesis were followed for more than 2 years, and were included in this study. The mean age at the time of the index operation was 8.3 years (range, 4...
November 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29127748/-issues-related-to-secondary-osteoporosis-associated-with-growth-hormone-deficiency-in-adulthood
#5
Martin Kužma, Peter Jackuliak, Zdenko Killinger, Peter Vaňuga, Juraj Payer
Growth hormone (GH) increases linear bone growth through complex hormonal reactions, mainly mediated by insulin like growth factor 1 (IGF1) that is produced mostly by hepatocytes under influence of GH and stimulates differentiation of epiphyseal prechondrocytes. IGF1 and GH play a key role in the linear bone growth after birth and regulation of bone remodelation during the entire lifespan. It is known that adult GH deficient (GHD) patients have decreased BMD and increased risk of low-impact fractures. Most data gathered thus far on the effect of GH replacement on bone status comprise the measurement of quantitative changes of bone mass...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29113210/analysis-of-imaging-characteristics-of-primary-malignant-bone-tumors-in-children
#6
Yingwei Sun, Xueyong Liu, Shinong Pan, Chunbo Deng, Xiaohan Li, Qiyong Guo
The present study aimed to investigate the imaging characteristics of primary malignant bone tumors in children. The imaging results of 34 children with primary malignant bone tumors confirmed by histopathological diagnosis between March 2008 and January 2014 were retrospectively analyzed. In total, 25 patients had osteosarcoma, with radiography and computed tomography (CT) showing osteolytic bone destruction or/and osteoblastic bone sclerosis, an aggressive periosteal reaction, a soft-tissue mass and cancerous bone...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29106040/the-effect-of-temporal-manipulation-of-tgf%C3%AE-3-and-fgf2-on-the-derivation-of-proliferative-chondrocytes-from-mensenchymal-stem-cells-a-study-monitored-by-qrt-pcr-and-molecular-beacon-based-nanosensors
#7
Li Min Tay, Christian Wiraja, Yingnan Wu, Zheng Yang, Eng Hin Lee, Chenjie Xu
Proliferative chondrocytes are critical to realize regeneration of damaged epiphyseal growth plate. However, acquiring autologous replacement cells involves highly-invasive procedures and often results in limited cell quantity. Mesenchymal stem cells (MSCs) are a potential source of chondrogenic cells for the treatment of cartilage disorders and injuries. The temporal effect of transforming growth factor beta 3 (TGFβ3) and fibroblast growth factor 2 (FGF2) on the derivation of proliferative chondrocytes from MSCs in 3D agarose was investigated by manipulating the duration of TGFβ3 and FGF2 treatment...
November 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29097920/contrast-enhanced-microtomographic-characterisation-of-vessels-in-native-bone-and-engineered-vascularised-grafts-using-ink-gelatin-perfusion-and-phosphotungstic-acid
#8
Sarah Sutter, Atanas Todorov, Tarek Ismail, Alexander Haumer, Ilario Fulco, Georg Schulz, Arnaud Scherberich, Alexandre Kaempfen, Ivan Martin, Dirk J Schaefer
Objectives: Bone ischemia and necrosis are challenging to treat, requiring investigation of native and engineered bone revascularisation processes through advanced imaging techniques. This study demonstrates an experimental two-step method for precise bone and vessel analysis in native bones or vascularised bone grafts using X-ray microtomography (μCT), without interfering with further histological processing. Methods: Distally ligated epigastric arteries or veins of 6 nude rats were inserted in central channels of porous hydroxyapatite cylinders and these pedicled grafts were implanted subcutaneously...
2017: Contrast Media & Molecular Imaging
https://www.readbyqxmd.com/read/29091914/a-new-giraffid-mammalia-ruminantia-pecora-from-the-late-miocene-of-spain-and-the-evolution-of-the-sivathere-samothere-lineage
#9
María Ríos, Israel M Sánchez, Jorge Morales
Giraffids include the only living giraffomorph ruminants and are diagnosed by the presence of bi-lobed canines and a special type of epiphyseal cranial appendages called ossicones. The family Giraffidae ranges from the latest early Miocene until today. However they are currently extant relics with only two living representatives, the African genera Okapia and Giraffa. Giraffids were much more diverse and widespread in the past, with more than 30 fossil species described. For the past decades a number of studies intended to resolve the phylogenetic relationships of the family, but due to the lack of really good cranial material no clear consensus was reached regarding the phylogenetic relationships amongst the different members of the group...
2017: PloS One
https://www.readbyqxmd.com/read/29091812/food-restriction-followed-by-refeeding-with-a-casein-or-whey-based-diet-differentially-affects-the-gut-microbiota-of-pre-pubertal-male-rats
#10
Majdi Masarwi, Hadas Isaac Solnik, Moshe Phillip, Sima Yaron, Raanan Shamir, Metsada Pasmanic-Chor, Galia Gat-Yablonski
Researchers are gaining an increasing understanding of host-gut microbiota interactions, but studies of the role of gut microbiota in linear growth are scarce. The aim of this study was to investigate the effect of food restriction and refeeding with different diets on gut microbiota composition in fast-growing rats. Young male Sprague-Dawley rats were fed regular rat chow ad libitum (control group) or subjected to 40% food restriction for 36 days followed by continued restriction or ad libitum refeeding for 24 days...
September 14, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29074299/angiopoietin-like-protein-2-promotes-chondrogenic-differentiation-during-bone-growth-as-a-cartilage-matrix-factor
#11
H Tanoue, J Morinaga, T Yoshizawa, M Yugami, H Itoh, T Nakamura, Y Uehara, T Masuda, H Odagiri, T Sugizaki, T Kadomatsu, K Miyata, M Endo, K Terada, H Ochi, S Takeda, K Yamagata, T Fukuda, H Mizuta, Y Oike
OBJECTIVE: Chondrocyte differentiation is crucial for long bone growth. Many cartilage extracellular matrix (ECM) proteins reportedly contribute to chondrocyte differentiation, indicating that mechanisms underlying chondrocyte differentiation are likely more complex than previously appreciated. Angiopoietin-like protein 2 (ANGPTL2) is a secreted factor normally abundantly produced in mesenchymal lineage cells such as adipocytes and fibroblasts, but its loss contributes to the pathogenesis of lifestyle- or aging-related diseases...
October 23, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29070026/a-biomechanical-comparison-of-kirschner-wire-fixation-on-fracture-stability-in-salter-harris-type-i-fractures-of-the-proximal-humeral-physis-in-a-porcine-cadaveric-model
#12
Jiawen Ma, Tian Wang, Vedran Lovric, Kenneth A Johnson, William R Walsh
BACKGROUND: The physis is the weakest component of immature long bones, and physeal fractures constitute about 30% of fractures in growing dogs. Fractures of the proximal humeral physis typically have a Salter Harris type I or II configuration. These fractures require accurate reduction and adequate stabilization to allow for any potential continued longitudinal bone growth, in conjunction with physeal fracture healing. Conventional internal fixation of these fractures involves insertion of two parallel Kirschner wires, although other methods described include tension band wiring, Rush pinning, and lag screws...
October 25, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29069147/effects-of-continual-intermittent-administration-of-parathyroid-hormone-on-implant-stability-in-the-presence-of-osteoporosis-an-in-vivo-study-using-resonance-frequency-analysis-in-a-rabbit-model
#13
Yoshifumi Oki, Kazuya Doi, Yusuke Makihara, Reiko Kobatake, Takayasu Kubo, Kazuhiro Tsuga
OBJECTIVE: This study aimed to evaluate the effects of continual intermittent administration of parathyroid hormone (PTH) on implant stability in the presence of osteoporosis, using rabbit models. MATERIAL AND METHODS: Fifteen female New Zealand white rabbits underwent ovariectomy and were administered glucocorticoids to induce osteoporosis, following which they were divided into three groups. The first group received intermittent subcutaneous PTH for 4 weeks until implant placement (PTH1), while the second and third groups received PTH (PTH2) and saline (control), respectively, for 4 weeks before and after implant placement...
September 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29064870/biomechanical-evaluation-of-pediatric-anterior-cruciate-ligament-acl-reconstruction-techniques-with-and-without-the-anterolateral-ligament-all
#14
Natasha Trentacosta, James L Pace, Melodie Metzger, Max Michalski, Trevor Nelson, Landon Polakof, Bert Mandelbaum
BACKGROUND: Two popular physeal-sparing procedures used in the management of anterior cruciate ligament (ACL) injuries in skeletally immature patients are the iliotibial band (ITB) ACL reconstruction (ACLR) and the all-epiphyseal (AE) ACLR. Although there has been concern for overconstraint of the lateral compartment of the knee with the ITB ACLR technique, rotational stability, as provided by the anterolateral ligament (ALL) and ACL, has not been assessed in the setting of pediatric ACLR techniques...
October 23, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29057471/delta-like-2-negatively-regulates-chondrogenic-differentiation
#15
Weifeng Xu, Yexin Wang, Haoming Zhao, Baotin Fan, Ke Guo, Ming Cai, Shanyong Zhang
Delta-like 2 (Dlk2), a glycoprotein highly homologous to Dlk1, belongs to the Notch/Delta/Serrata family. Dlk2 has been shown to be an important regulator of adipogenesis; however, its role in other cellular differentiation processes is still unknown. Therefore, in this study, we aimed to determine the role of Dlk2 in chondrogenic differentiation. We found that Dlk2 overexpression promoted the growth of ATDC5 cells but inhibited insulin-induced ATDC5 chondrogenic differentiation, as supported by the reduction in cartilage matrix formation and gene expression of aggrecan(acan), collagenType II (col2a1) and X (col10a1)...
October 23, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29056291/an-in-vivo-model-of-a-mechanically-induced-bone-marrow-lesion
#16
Jonathan B Matheny, Matthew G Goff, Sarah L Pownder, Matthew F Koff, Kei Hayashi, Xu Yang, Mathias P G Bostrom, Marjolein C H van der Meulen, Christopher J Hernandez
Bone marrow lesions (BMLs) are radiologic abnormalities in magnetic resonance images of subchondral bone that are correlated with osteoarthritis. Little is known about the physiologic processes within a BML, although BMLs are associated with mechanical stress, bone tissue microdamage and increased bone remodeling. Here we establish a rabbit model to study the pathophysiology of BMLs. We hypothesized that in vivo loads that generate microdamage in cancellous bone would also create BMLs and increase bone remodeling...
November 7, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29054894/mucopolysaccharidosis-type-iva-morquio-a-a-close-differential-diagnosis-of-spondylo-epiphyseal-dysplasia
#17
Sugata Narayan Biswas, Shinjan Patra, Partha Pratim Chakraborty, Himanshu Barman
Patients with mucopolysaccharidoses (MPS) have a plethora of multisystemic manifestations depending on the particular type, and atypical presentations are not uncommon. MPS type IVA (Morquio A syndrome) has predominant musculoskeletal system involvement and corneal clouding with normal intelligence and can be misdiagnosed as primary skeletal disorders in clinical practice. The absence of corneal clouding with normal urinary glycosaminoglycans (GAGs) level in a proportion of patients with MPS IVA makes the correct diagnosis even more challenging for physicians...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29051055/skeletal-impairment-in-pierson-syndrome-is-there-a-role-for-laminin%C3%AE-2-in-bone-physiology
#18
Camille Beaufils, Delphine Farlay, Irma Machuca-Gayet, Alice Fassier, Martin Zenker, Caroline Freychet, Edith Bonnelye, Aurélia Bertholet-Thomas, Bruno Ranchin, Justine Bacchetta
INTRODUCTION: Pierson syndrome is caused by a mutation of LAMB2, encoding for laminin β2. Clinical phenotype is variable but usually associates congenital nephrotic syndrome (CNS) and ocular abnormalities. Neuromuscular impairment has also been described. METHODS: We report on a 15-year old girl, suffering from Pierson Syndrome, who developed severe bone deformations during puberty. This patient initially displayed CNS and microcoria, leading to the clinical diagnosis of Pierson syndrome...
October 16, 2017: Bone
https://www.readbyqxmd.com/read/29044618/ultrasonographic-screening-for-subclinical-osteochondrosis-of-the-femoral-trochlea-in-foals-28-166-days-old-a-prospective-farm-study
#19
G Martel, D Crowley, J Olive, J Halley, S Laverty
BACKGROUND: Extensive osteochondritis dissecans (OCD) lesions of the lateral ridge of the trochlea of the femur (LRTF), the most common OCD- affected site in the stifle, have a poor outcome with surgical debridement and can be career ending. The early detection of osteochondrosis lesions and their conservative management holds the promise to enhance outcome. We hypothesise that ultrasonography is a valuable field screening tool to detect and monitor early subclinical LRTF osteochondrosis...
October 17, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29043101/protective-effect-of-rhus-verniciflua-stokes-extract-in-an-experimental-model-of-post-menopausal-osteoporosis
#20
Ji Heun Jeong, Jong Hoon An, Hui Yang, Do-Kyung Kim, Nam-Seob Lee, Young-Gil Jeong, Chun Soo Na, Dae Seung Na, Mi-Sook Dong, Seung Yun Han
Post-menopausal osteoporosis (PMO) is a major global human health concern. Owing to the need for therapeutic drugs without side effects, natural extracts containing various polyphenolic compounds that may exert estrogenic effects have been studied in depth. Rhus verniciflua Stokes (RVS), which has been used as a traditional herbal medicine for centuries in Korea, was recently revealed to exert estrogenic effects attributable to its bioactive ingredients sulfuretin and butein, which have strong estrogen receptor-binding affinities...
September 2017: Anatomy & Cell Biology
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