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https://www.readbyqxmd.com/read/28925593/fine-needle-aspiration-biopsy-diagnosis-of-primary-clear-cell-chondrosarcoma-a-case-report
#1
Kelsey E McHugh, Cynthia L Emory, Graham E Parks, Scott E Kilpatrick
Clear cell chondrosarcoma is a rare chondrosarcoma variant often involving the long bone epiphyses of young to middle aged adults. We report herein a case involving the left femoral head in a 25-year-old female with a 3-month history of worsening left hip pain. Radiographs revealed a complex, multifocal and lytic lesion centered in the left proximal femoral epiphysis with involvement of the femoral neck. Computed tomography-guided fine needle aspiration biopsy with concomitant core needle biopsy was performed, and a diagnosis of clear cell chondrosarcoma was rendered...
September 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28923047/prepubertal-onset-of-slipped-capital-femoral-epiphysis-associated-with-hypothyroidism-a-case-report-and-literature-review
#2
Saori Kadowaki, Tomohiro Hori, Hideki Matsumoto, Kaori Kanda, Michio Ozeki, Yu Shirakami, Norio Kawamoto, Hidenori Ohnishi, Toshiyuki Fukao
BACKGROUND: Slipped capital femoral epiphysis (SCFE) is a common hip disorder characterized by displacement of the capital femoral epiphysis from the metaphysic through the femoral epiphyseal plate. SCFE usually occurs during puberty, with obesity a common risk factor. We experienced a rare case of SCFE associated with hypothyroidism in a prepubescent patient who was not obese. CASE PRESENTATION: The patient was an 8-year-old boy suffering from bilateral SCFE with hypothyroidism...
September 18, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28919430/role-of-subchondral-bone-properties-and-changes-in-development-of-load-induced-osteoarthritis-in-mice
#3
Olufunmilayo O Adebayo, Frank C Ko, Philip T Wan, Steven R Goldring, Mary B Goldring, Timothy M Wright, Marjolein C H van der Meulen
OBJECTIVE: Animal models recapitulating post-traumatic osteoarthritis (OA) suggest that subchondral bone (SCB) properties and remodeling may play major roles in disease initiation and progression. Thus, we investigated the role of SCB properties and its effects on load-induced OA progression by applying a tibial loading model on two distinct mouse strains treated with alendronate (ALN). DESIGN: Cyclic compression was applied to the left tibia of 26-week-old male C57Bl/6 (B6, low bone mass) and FVB (high bone mass) mice...
September 14, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28905737/giant-cell-tumor-of-bone-revisited
#4
Andreas F Mavrogenis, Vasileios G Igoumenou, Panayiotis D Megaloikonomos, Georgios N Panagopoulos, Panayiotis J Papagelopoulos, Panayotis N Soucacos
Giant cell tumor (GCT) of bone is a locally aggressive benign neoplasm that is associated with a large biological spectrum ranging from latent benign to highly recurrent and occasionally metastatic malignant bone tumor. It accounts for 4-10% of all bone tumors and typically affects the meta-epiphyseal region of long bones of young adults. The most common site involved is the distal femur, followed by the distal radius, sacrum, and proximal humerus. Clinical symptoms are nonspecific and may include local pain, swelling, and limited range of motion of the adjacent joint...
2017: SICOT-J
https://www.readbyqxmd.com/read/28904732/-type-iii-monteggia-lesion-a-rare-association-about-a-case
#5
Mohamed Amine Oukhouya, Hind Abou El Jaoud, Saad Andaloussi, Hicham Abdellaoui, Karima Atarraf, Lamia Chater, My Abderrahman Afifi
Type III Monteggia lesion is very rare, usually occurring within a context of violent trauma and often going unnoticed. We report the case of a 11-year old boy presenting to the Emergency Department with blunt trauma of the upper limb. The radiological evaluation showed olecranon fracture and radial epiphyseal separation associated with dislocation of the radial head. The patient underwent orthopedic treatment with good outcome after a mean follow-up of 3 months.
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28902435/longitudinal-effects-of-single-hindlimb-radiation-therapy-on-bone-strength-and-morphology-at-local-and-contralateral-sites
#6
Megan E Oest, Connor G Policastro, Kenneth A Mann, Nicholas D Zimmerman, Timothy A Damron
Radiation therapy (RTx) is associated with increased risk for late-onset fragility fractures in bone tissue underlying the radiation field. Bone tissue outside the RTx field is often selected as a "normal" comparator tissue in clinical assessment of fragility fracture risk, but the robustness of this comparison is limited by an incomplete understanding of the systemic effects of local radiotherapy. In this study, a mouse model of limited field irradiation was used to quantify longitudinal changes in local (irradiated) and systemic (non-irradiated) femurs with respect to bone density, morphology, and strength...
September 13, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28899428/proximal-tibial-trabecular-bone-mineral-density-is-related-to-pain-in-patients-with-osteoarthritis
#7
Wadena D Burnett, Saija A Kontulainen, Christine E McLennan, Diane Hazel, Carl Talmo, David R Wilson, David J Hunter, James D Johnston
BACKGROUND: Our objective was to examine the relationships between proximal tibial trabecular (epiphyseal and metaphyseal) bone mineral density (BMD) and osteoarthritis (OA)-related pain in patients with severe knee OA. METHODS: The knee was scanned preoperatively using quantitative computed tomography (QCT) in 42 patients undergoing knee arthroplasty. OA severity was classified using radiographic Kellgren-Lawrence scoring and pain was measured using the pain subsection of the Western Ontario and McMaster Universities Arthritis Index (WOMAC)...
September 12, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28892125/novel-spondyloepimetaphyseal-dysplasia-due-to-ufsp2-gene-mutation
#8
M Di Rocco, M Rusmini, F Caroli, A Madeo, M Bertamino, G Marre-Brunenghi, I Ceccherini
Beukes Hip Dysplasia is an autosomal dominant disease which has to date been described only in a large South African family of Dutch origin. The patients presented with progressive epiphyseal dysplasia limited to femoral capital epiphysis and their height was not significantly reduced. A unique variant of the ubiquitin-fold modifier 1 (Ufm1)-specific peptidase 2 (UFSP2) gene (c.868T>C) has been reported in all individuals from Beukes family with clinical and radiological diagnosis of Beukes Hip Dysplasia...
September 11, 2017: Clinical Genetics
https://www.readbyqxmd.com/read/28889331/magnetic-resonance-imaging-based-evaluation-of-ossification-of-the-medial-clavicular-epiphysis-in-forensic-age-assessment
#9
S Schmidt, C Ottow, H Pfeiffer, W Heindel, V Vieth, A Schmeling, R Schulz
Evaluation of the degree of ossification of the medial clavicular epiphysis plays a crucial role in determining with an adequate degree of probability whether legally relevant age boundaries after the age of 17 have been crossed. In view of the need to avoid unnecessary radiation exposure, establishing non-X-ray methods for investigating the clavicle has long been a key objective in forensic age assessment research. Based on magnetic resonance imaging examinations in a large sample of healthy subjects, the current study for the first time presents statistical measures which allow inferences to be drawn for forensic age assessment in both sexes...
September 9, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28888389/scheuermann-s-disease-in-a-juvenile-male-from-the-late-roman-necropolis-of-torrenueva-3rd-4th-century-ce-granada-spain
#10
Joan Viciano, Sandra López-Lázaro, Ángela Pérez-Fernández, Anabel Amores-Ampuero, Ruggero D'Anastasio, José Miguel Jiménez-Triguero
This study details a severe case of Scheuermann's disease (SD) in a well-preserved skeleton of a juvenile male (designated TOR302), dated to 3rd-4th century CE, from the late Roman necropolis of Torrenueva (Granada, Spain). Individual TOR302 shows an evident kyphotic curve in the thoraco-lumbar spine, which is characterised by: (i) vertebral bodies of thoracic vertebra T2, thoracic segment T4-T9, and thoraco-lumbar segment T12-L2 wedged at >5°; (ii) slight anterior extensions of the epiphyseal ring; (iii) Schmorl's nodes on the superior and/or inferior plates; and (iv) a Cobb angle of 75°, derived from thoracic segments T4-T9...
September 2017: International Journal of Paleopathology
https://www.readbyqxmd.com/read/28884107/giant-cell-tumor-locally-advanced-around-the-knee-treatment-and-literature-review
#11
REVIEW
Ana Valeria Rigollino, Thiago Santos Fernando, Marcos Hajime Tanaka, Marcello Martins Souza
Giant cell tumor (GCT) is a benign bone tumor with aggressive characteristics. They are more prevalent in the third decade of life and demonstrate a preference for locating in the epiphyseal region of long bones. They have a high local recurrence rate, which depends on the type of treatment and initial tumor presentation. The risk of lung metastases is around 3%. Between October 2010 and August 2014, nine patients diagnosed with locally advanced GCT or with pathological fracture to the knee level underwent surgical treatment...
June 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28878537/arthroscopically-assisted-surgical-fixation-of-a-juvenile-tillaux-fracture-and-implant-removal-a-case-report
#12
Takahisa Ogawa, Sadanori Shimizu
Juvenile Tillaux fractures are Salter-Hallis III fractures of the distal tibial epiphysis that occur only when the tibial epiphyses are closing. Theoretically, arthroscopically assisted reduction and fixation of a juvenile Tillaux fracture can facilitate the accurate reconstruction of the articular surface, using arthroscopic visualization. We treated a girl aged 14 years who had a juvenile Tillaux fracture by using arthroscopically assisted reduction and fixation. In order to obtain articular congruency, the screw was inserted under arthroscopic visualization...
August 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28878530/oldest-epiphyseal-osteochondroma-in-a-subadult-from-ancient-egypt
#13
Albert Isidro, Josep Maria Catalán, Carme Prat, Ferran Torner
Benign bone tumours are pathologies frequently encountered in archaeological human remains, with the most common being osteoma and osteochondroma. We present the case of a juvenile individual recovered from the Necropolis of Sharuna, Middle Egypt and dated to the end of Old Kingdom and First Intermediate Period of Ancient Egypt (circa 2150 BC), showing an osteochondroma arising from the proximal epiphysis of the right tibia which, in all likelihood, affected the patellar tendon in life. Osteochondromas are usually discovered during childhood and adolescence...
August 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28875156/asporin-stably-expressed-in-the-surface-layer-of-mandibular-condylar-cartilage-and-augmented-in-the-deeper-layer-with-age
#14
Yutaka Miyamoto, Hiroyuki Kanzaki, Satoshi Wada, Sari Tsuruoka, Kanako Itohiya, Kenichi Kumagai, Yoshiki Hamada, Yoshiki Nakamura
Mandibular condylar cartilage (MCC) exhibits dual roles both articular cartilage and growth center. Of many growth factors, TGF-β has been implicated in the growth of articular cartilage including MCC. Recently, Asporin, decoy to TGF-β, was discovered and it blocks TGF-β signaling. Asporin is expressed in a variety of tissues including osteoarthritic articular cartilage, though there was no report of Asporin expression in MCC. In the present study, we investigated the temporal and spatial expression of Asporin in MCC...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/28874841/epiphyseal-bone-formation-occurs-via-thyroid-hormone-regulation-of-chondrocyte-to-osteoblast-transdifferentiation
#15
Patrick Aghajanian, Weirong Xing, Shaohong Cheng, Subburaman Mohan
Endochondral ossification in the diaphysis of long bones has been studied in-depth during fetal development but not postnatally in the epiphysis. Immunohistochemical studies revealed that Sox9 and Col2 expressing immature chondrocytes in the epiphysis transition into prehypertrophic and hypetrophic chondrocytes and finally into osteoblasts expressing Col1 and BSP during postnatal day 7-10, when serum levels of thyroid hormone (TH) rise. Lineage tracing using Rosa-td tomato (Col2-Cre-ERT2) mice treated with tamoxifen indicated that the same Col2 expressing chondrocytes expressed prehypertrophic, hypertrophic, and subsequently bone formation markers in a sequential manner in euthyroid but not hypothyroid mice, thus providing evidence that chondrocyte to osteoblast transdifferentiation is TH-dependent...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28872525/thumb-ossification-composite-index-toci-for-predicting-peripubertal-skeletal-maturity-and-peak-height-velocity-in-idiopathic-scoliosis-a-validation-study-of-premenarchal-girls-with-adolescent-idiopathic-scoliosis-followed-longitudinally-until-skeletal-maturity
#16
Alec L H Hung, W W Chau, B Shi, Simon K Chow, Fiona Y P Yu, T P Lam, Bobby K W Ng, Y Qiu, Jack C Y Cheng
BACKGROUND: Accurate skeletal maturity assessment is important to guide clinical evaluation of idiopathic scoliosis, but commonly used methods are inadequate or too complex for rapid clinical use. The objective of the study was to propose a new simplified staging method, called the thumb ossification composite index (TOCI), based on the ossification pattern of the 2 thumb epiphyses and the adductor sesamoid bone; to determine its accuracy in predicting skeletal maturation when compared with the Sanders simplified skeletal maturity system (SSMS); and to validate its interrater and intrarater reliability...
September 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28867279/investigating-hominin-carnivory-in-the-okote-member-of-koobi-fora-kenya-with-an-actualistic-model-of-carcass-consumption-and-traces-of-butchery-on-the-elbow
#17
Stephen R Merritt
Previous zooarchaeological analysis at Koobi Fora indicates that Okote Member hominins were the primary agents of bone assemblage formation, gained early access to large and small mammal flesh, and consumed both high- and low-ranked carcass parts. The discovery of additional butchered specimens prompted the re-analysis presented here of three large and well-preserved zooarchaeological assemblages from the Okote member, GaJi14, FwJj14N and FwJj14S, to revisit paleoecological hypotheses about tool-assisted carnivory...
August 31, 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28860685/modyfied-wedge-osteotomy-for-osteoarthritis-of-elbow-secondary-to-osteochondritis-dissecans-in-adolecent-with-multiple-epiphyseal-dysplasia-a-case-report
#18
Takashi Yoshida, Wook-Cheol Kim, Yoshinobu Oka, Masashi Nakase, Atsushi Nishida, Hiroaki Wada, Yuji Arai, Toshikazu Kubo
Multiple epiphyseal dysplasia (MED) may be complicated by osteochondritis dissecans (OCD), most commonly reported in the knee, but involvement of the elbow is very rare. Optimal treatment for MED-associated elbow OCD and treatment outcome have not been established. This report describes the case of an adolescent male patient with elbow OCD treated by arthroscopic drilling at a previous clinic. Progression of osteoarthritis and radial head subluxation were observed. Resection of the osteophytes and modified wedge osteotomy of the lateral condyle were then performed, and a favorable result was obtained by decompression and sufficient congruency of the radiohumeral joint...
December 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28856432/kruppel-like-factor-4-regulates-matrix-metalloproteinase-and-aggrecanase-gene-expression-in-chondrocytes
#19
Junji Fujikawa, Yuto Takeuchi, Satoshi Kanazawa, Ahmed G Nomir, Akiyoshi Kito, Eman Elkhashab, Amr M Ghaleb, Vincent W Yang, Shigehisa Akiyama, Ichijiro Morisaki, Takashi Yamashiro, Satoshi Wakisaka, Makoto Abe
Kruppel-like factor 4 (KLF4) is a zinc finger transcription factor that plays crucial roles during the development and maintenance of multiple organs. We and others have previously shown that KLF4 is involved in bone modeling and remodeling but roles played by KLF4 during skeletogenesis are still not fully understood. Here, we show that KLF4 is expressed in the epiphyseal growth plate and articular chondrocytes. Most articular chondrocytes expressed KLF4 in embryos but it localized only in a subset of superficial zone cells in postnatal mice...
August 31, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28854412/wide-spread-cone-shaped-epiphyses-in-two-saudi-siblings-with-ellis-van-creveld-syndrome
#20
Abeer Al-Fardan, Mohammad M Al-Qattan
INTRODUCTION: Ellis-van Creveld (EVC) syndrome is one of the rarest ciliopathy syndromes. It is caused by mutations of the EVC and EVC2 genes which encode the EVC proteins present in the basal body of the primary cilium. PRESENTATION OF CASES: We report on a Saudi family with two affected children. Gene analysis revealed a homozygous c.2T >A in exon 1 of the EVC gene. The most interesting finding in our patients was the wide - spread cone-shaped epiphyses in the hands and feet...
August 24, 2017: International Journal of Surgery Case Reports
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