keyword
https://read.qxmd.com/read/37810754/cartilage-fragments-combined-with-bmscs-derived-exosomes-can-promote-tendon-bone-healing-after-acl-reconstruction
#21
JOURNAL ARTICLE
Chi Zhang, Chao Jiang, Jiale Jin, Pengfei Lei, Youzhi Cai, Yue Wang
Anterior cruciate ligament reconstruction (ACLR) often fails due to the inability of tendon-bone integration to regenerate normal tissues and formation of fibrous scar tissues in the tendon-bone interface. Cartilage fragments and exosomes derived from bone mesenchymal stromal cells (BMSCs-Exos) can enhance enthesis healing. Nevertheless, the effects on the tendon-bone healing of ACLR remain unknown. This study found that BMSCs-Exos can promote the proliferation of chondrocytes in cartilage fragments, and activated the expression of chondro-related genes SOX9 and Aggrecan...
December 2023: Materials today. Bio
https://read.qxmd.com/read/37779043/therapeutic-effects-of-albumin-fused-bmp7-on-2-experimental-models-of-liver-fibrosis
#22
JOURNAL ARTICLE
Mei Takano, Hiroshi Watanabe, Shota Toda, Kento Nishida, Tadashi Imafuku, Yuki Minayoshi, Takehiro Nakano, Hitoshi Maeda, Toru Maruyama
Despite the fact that liver fibrosis is an intractable disease with a poor prognosis, effective therapeutic agents are not available. In this study, we focused on bone morphogenetic factor 7 (BMP7) that inhibits transforming growth factor (TGF)-β signaling, which is involved in liver fibrosis. We prepared an albumin-fused BMP7 (HSA-BMP7) that is retained in the blood and evaluated its inhibitory effect on liver fibrosis. Bile duct ligated mice were used as an acute liver fibrosis model, and carbon tetrachloride-induced liver fibrosis mice were used as a chronic model...
2023: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/37778594/a-self-gelling-hydrogel-based-on-thiolated-hyaluronic-acid-for-three-dimensional-culture-of-ovine-preantral-follicles
#23
JOURNAL ARTICLE
Tayebeh Dahmardeh, Mohammad Hossein Ghanian, Bita Ebrahimi
Three-dimensional (3D) ovarian follicle culture offers a promising option for fertility preservation in patients who cannot receive ovarian tissue transplantation. Our research evaluated the potential of a hydrogel composed of thiolated hyaluronic acid (HA-SH) for ovine preantral follicle development compared to routinely used alginate hydrogel (ALG). Synthesized via a carbodiimide reaction, HA-SH facilitated a self-crosslinking hydrogel through disulfide bond formation. Ovine preantral follicles (200-300 μm) retrieved through mechanical and enzymatic methods were encapsulated individually in either ALG or HA-SH hydrogels...
September 29, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/37702430/diffuse-midline-glioma-invasion-and-metastasis-rely-on-cell-autonomous-signaling
#24
JOURNAL ARTICLE
Marco Bruschi, Lilia Midjek, Yassine Ajlil, Stephanie Vairy, Manon Lancien, Samia Ghermaoui, Thomas Kergrohen, Maïté Verreault, Ahmed Idbaih, Carlos Alberto Oliveira de Biagi, Ilon Liu, Mariella G Filbin, Kévin Beccaria, Thomas Blauwblomme, Stephanie Puget, Arnault Tauziede-Espariat, Pascale Varlet, Volodia Dangouloff-Ros, Nathalie Boddaert, Gwenael Le Teuff, Jacques Grill, Guillaume Montagnac, Nadia Elkhatib, Marie-Anne Debily, David Castel
BACKGROUND: Diffuse midline gliomas (DMG) are pediatric tumors with negligible two-year survival after diagnosis characterized by their ability to infiltrate the central nervous system. In the hope of controlling the local growth and slowing the disease all patients receive radiotherapy. However, distant progression occurs frequently in DMG patients. Current clues as to what causes tumor infiltration circle mainly around the tumor microenvironment, but there are currently no known determinants to predict the degree of invasiveness...
September 13, 2023: Neuro-oncology
https://read.qxmd.com/read/37688374/high-bmp7-expression-is-associated-with-poor-prognosis-in-ovarian-cancer
#25
JOURNAL ARTICLE
Richa Vasan, Jahnavi Yadav, Radhika Aiyappa-Maudsley, Suha Deen, Sarah J Storr, Stewart G Martin
Bone Morphogenetic Protein 7 (BMP7) is an extracellular signalling protein that belongs to the transforming growth factor-β (TGF- β) superfamily. Previous transcriptomic data suggested that BMP7 expression may be disrupted in ovarian carcinoma and may play an important role in the aggressiveness of the disease. However, the protein expression in patient tumours has not been well studied. The current study aimed to assess BMP7 protein expression in a large cohort of ovarian carcinoma patient tumour samples to establish its associations with different clinical endpoints...
September 8, 2023: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/37628941/expression-levels-of-the-tnni3k-gene-in-the-heart-are-highly-associated-with-cardiac-and-glucose-metabolism-related-phenotypes-and-functional-pathways
#26
JOURNAL ARTICLE
Qingqing Gu, Buyan-Ochir Orgil, Akhilesh Kumar Bajpai, Yufeng Chen, David G Ashbrook, Athena Starlard-Davenport, Jeffrey A Towbin, Djamel Lebeche, Enkhsaikhan Purevjav, Hongzhuan Sheng, Lu Lu
BACKGROUND: Troponin-I interacting kinase encoded by the TNNI3K gene is expressed in nuclei and Z-discs of cardiomyocytes. Mutations in TNNI3K were identified in patients with cardiac conduction diseases, arrhythmias, and cardiomyopathy. METHODS: We performed cardiac gene expression, whole genome sequencing (WGS), and cardiac function analysis in 40 strains of BXD recombinant inbred mice derived from C57BL/6J (B6) and DBA/2J (D2) strains. Expression quantitative trait loci (eQTLs) mapping and gene enrichment analysis was performed, followed by validation of candidate Tnni3k -regulatory genes...
August 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37626658/therapeutic-potential-of-bmp7-in-the-treatment-of-osteoporosis-caused-by-the-interaction-between-inflammation-and-corticosteroids-in-inflammatory-bowel-disease
#27
JOURNAL ARTICLE
Ivana Smoljan, Dijana Detel, Suncica Buljevic, Igor Erjavec, Ivana Marić
UNLABELLED: Individuals with inflammatory bowel disease (IBD) have an increased risk of bone impairment, which is a process controlled by the RANKL/RANK/OPG system, mostly due to chronic inflammation and corticosteroid treatment. Bone morphogenic protein 7 (BMP7) has a complex role in maintaining inflammation and bone remodeling but little is known about its anti-inflammatory potential in chronic colitis. We investigated the effect of systemically administered BMP7 and corticosteroids on the severity of inflammation, macrophage differentiation, and bone regeneration in a chronic IBD model...
August 1, 2023: Biomedicines
https://read.qxmd.com/read/37607547/skin-type-dependent-development-of-murine-mechanosensory-neurons
#28
JOURNAL ARTICLE
Charalampia Koutsioumpa, Celine Santiago, Kiani Jacobs, Brendan P Lehnert, Victor Barrera, John N Hutchinson, Dhane Schmelyun, Jessica A Lehoczky, David L Paul, David D Ginty
Mechanosensory neurons innervating the skin underlie our sense of touch. Fast-conducting, rapidly adapting mechanoreceptors innervating glabrous (non-hairy) skin form Meissner corpuscles, while in hairy skin, they associate with hair follicles, forming longitudinal lanceolate endings. How mechanoreceptors develop axonal endings appropriate for their skin targets is unknown. We report that mechanoreceptor morphologies across different skin regions are indistinguishable during early development but diverge post-natally, in parallel with skin maturation...
August 14, 2023: Developmental Cell
https://read.qxmd.com/read/37603701/reveal-the-potential-molecular-mechanism-of-circrna-regulating-immune-related-mrna-through-sponge-mirna-in-the-occurrence-and-immune-regulation-of-papillary-thyroid-cancer
#29
JOURNAL ARTICLE
Bo Wang, Wei Shen, Li Yan, Xiaoyu Li, Linlei Zhang, Suyuan Zhao, Xiao Jin
BACKGROUND: Papillary thyroid cancer (PTC) is the most common endocrine malignant tumour. The purpose of this study was to explore the potential molecular mechanism of circRNA regulating immune-related mRNA through sponge miRNA in the occurrence and immune regulation of PTC. METHODS: All data were downloaded from public databases, such as GEO, Immport and TCGA. Differentially expressed (DE) mRNAs (DEmRNAs), DEmiRNAs and DEcircRNAs were identified using metaMA and limma packages...
2023: Annals of Medicine
https://read.qxmd.com/read/37600656/immune-related-gene-il17ra-as-a-diagnostic-marker-in-osteoporosis
#30
JOURNAL ARTICLE
Ya-Jun Deng, Zhi Li, Bo Wang, Jie Li, Jun Ma, Xiong Xue, Xin Tian, Quan-Cheng Liu, Ying Zhang, Bin Yuan
Objectives: Bone immune disorders are major contributors to osteoporosis development. This study aims to identify potential diagnostic markers and molecular targets for osteoporosis treatment from an immunological perspective. Method: We downloaded dataset GSE56116 from the Gene Expression Omnibus database, and identified differentially expressed genes (DEGs) between normal and osteoporosis groups. Subsequently, differentially expressed immune-related genes (DEIRGs) were identified, and a functional enrichment analysis was performed...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37575306/overexpression-of-nt-3-in-the-hippocampus-suppresses-the-early-phase-of-the-adult-neurogenic-process
#31
JOURNAL ARTICLE
Nanami Kasakura, Yuka Murata, Asuka Shindo, Shiho Kitaoka, Tomoyuki Furuyashiki, Kanzo Suzuki, Eri Segi-Nishida
The dentate gyrus (DG) of the hippocampus regulates stress-related emotional behaviors and ensures neurogenesis throughout life. Neurotrophin-3 (NT-3) is a neurotrophic factor that regulates neuronal differentiation, survival, and synaptic formation in both the peripheral and central nervous systems. NT-3 is expressed in the adult DG of the hippocampus; several chronic stress conditions enhance NT-3 expression in rodents. However, functional modulation of the adult DG by NT-3 signaling remains unclear. To directly investigate the impact of NT-3 on DG function, NT-3 was overexpressed in the hippocampal ventral DG by an adeno-associated virus carrying NT-3 (AAV-NT-3)...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/37541558/a-bone-morphogenetic-protein-regulates-the-shell-formation-of-crassostrea-gigas-under-ocean-acidification
#32
JOURNAL ARTICLE
Yuqian Gao, Zhaoqun Liu, Ting Zhu, Xiaoyu Xin, Yuhao Jin, Lingling Wang, Chang Liu, Linsheng Song Funding
Bone morphogenetic proteins (BMPs) are key factors controlling osteoblast differentiation, which have been proved to be involved in the hard tissue formation of marine mollusks. In the present study, a member of BMPs gene (CgBMP7) was identified from Pacific oyster Crassostrea gigas (C. gigas) with the aim to understand its possible role in the regulation of shell formation under ocean acidification (OA) conditions. The open reading frame (ORF) of CgBMP7 was of 1254 bp encoding a polypeptide of 417 amino acids...
August 2, 2023: Gene
https://read.qxmd.com/read/37539048/microenvironmental-and-cell-intrinsic-factors-governing-human-cdc2-differentiation-and-monocyte-reprogramming
#33
JOURNAL ARTICLE
Magdalena Lang, Corinna Krump, Anastasia Meshcheryakova, Carmen Tam-Amersdorfer, Elke Schwarzenberger, Christina Passegger, Sally Connolly, Diana Mechtcheriakova, Herbert Strobl
cDC2s occur abundantly in peripheral tissues and arise from circulating blood cDC2s. However, the factors governing cDC2 differentiation in tissues, especially under inflammatory conditions, remained poorly defined. We here found that psoriatic cDC2s express the efferocytosis receptor Axl and exhibit a bone morphogenetic protein (BMP) and p38MAPK signaling signature. BMP7, strongly expressed within the lesional psoriatic epidermis, cooperates with canonical TGF-β1 signaling for inducing Axl+ cDC2s from blood cDC2s in vitro ...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37530654/circ_0001666-upregulation-promotes-intestinal-epithelial-cell-fibrosis-in-pediatric-crohn-s-disease-via-the-srsf1-bmp7-axis
#34
JOURNAL ARTICLE
Jun Li, Ji-Zhi Xu, Bo Dou, Teng-Fei Huang, Jie Chen, Tuan-Mei Wang, Hong-Juan Ouyang
The epithelial-mesenchymal transition (EMT) is closely associated with Crohn's disease (CD) related intestinal fibrosis, a condition whose prevalence is increasing annually among children. Recently, the CD marker gene microarray screening revealed an upregulation of circ_0001666 in the colon tissues of CD patients, but its underlying mechanisms remain unclear. In this study, we explored the molecular mechanism of circ_0001666 in regulating EMT-mediated fibrosis in CD in vitro. The levels of circ_0001666 and EMT-associated proteins were assessed in CD clinical samples, and a CD cell model was established using TGF-β1 to induce human intestinal epithelial cells (HIECs)...
August 2, 2023: Kaohsiung Journal of Medical Sciences
https://read.qxmd.com/read/37511251/-albizia-julibrissin-exerts-anti-obesity-effects-by-inducing-the-browning-of-3t3l1-white-adipocytes
#35
JOURNAL ARTICLE
Yuna Kim, Hyanggi Ji, Dehun Ryu, Eunae Cho, Deokhoon Park, Eunsun Jung
This study investigated the effects of the Albizia julibrissin Leaf extracts (AJLE) on adipocytes using 3T3-L1 cells. AJLE inhibited adipogenesis by reducing the expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding proteins (C/EBPs) that regulate enzymes involved in fat synthesis and storage, and subsequently reduced intracellular lipid droplets, glycerol-3-phosphate dehydrogenase (GPDH), and triglyceride (TG). AJLE also increased the expression of brown adipocyte markers, such as uncoupling protein-1 (UCP-1), PR/SET domain 16 (PRDM16), and bone morphogenetic protein 7 (BMP7) by inducing the differentiation of brown adipocytes, as shown by a decrease in the lipid droplet sizes and increasing mitochondrial mass...
July 15, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37504303/interactions-of-pirnas-with-the-mrna-of-candidate-genes-in-esophageal-squamous-cell-carcinoma
#36
JOURNAL ARTICLE
Aizhan Rakhmetullina, Aigul Akimniyazova, Togzhan Niyazova, Anna Pyrkova, Makpal Tauassarova, Anatoliy Ivashchenko, Piotr Zielenkiewicz
Recently, a database of human piRNAs (piwi-interacting RNAs) was created, which allows the study of the binding of many piRNAs to the mRNAs of genes involved in many diseases, including cancer. In the present work, we identified the piRNAs that can interact with candidate esophageal squamous cell carcinoma (ESCC) genes. The binding of 480 thousand piRNAs with the mRNAs of 66 candidate ESCC genes was studied. Bioinformatic studies found that piRNAs bind only to the mRNAs of nine candidate genes: AURKA , BMP7 , GCOM1 , ERCC1 , MTHFR , SASH1 , SIX4 , SULT1A1 , and TP53 ...
July 23, 2023: Current Issues in Molecular Biology
https://read.qxmd.com/read/37502679/addition-of-heparin-binding-sites-strongly-increases-the-bone-forming-capabilities-of-bmp9-in-vivo
#37
JOURNAL ARTICLE
Claudia Siverino, Shorouk Fahmy-Garcia, Viktoria Niklaus, Nicole Kops, Laura Dolcini, Massimiliano Maraglino Misciagna, Yanto Ridwan, Eric Farrell, Gerjo J V M van Osch, Joachim Nickel
Bone Morphogenetic proteins (BMPs) like BMP2 and BMP7 have shown great potential in the treatment of severe bone defects. In recent in vitro studies, BMP9 revealed the highest osteogenic potential compared to other BMPs, possibly due to its unique signaling pathways that differs from other osteogenic BMPs. However, in vivo the bone forming capacity of BMP9-adsorbed scaffolds is not superior to BMP2 or BMP7. In silico analysis of the BMP9 protein sequence revealed that BMP9, in contrast to other osteogenic BMPs such as BMP2, completely lacks so-called heparin binding motifs that enable extracellular matrix (ECM) interactions which in general might be essential for the BMPs' osteogenic function...
November 2023: Bioactive Materials
https://read.qxmd.com/read/37494289/integrative-omics-reveals-rapidly-evolving-regulatory-sequences-driving-primate-brain-evolution
#38
JOURNAL ARTICLE
Xiao-Lin Zhuang, Jin-Jin Zhang, Yong Shao, Yaxin Ye, Chun-Yan Chen, Long Zhou, Zheng-Bo Wang, Xin Luo, Bing Su, Yong-Gang Yao, David N Cooper, Ben-Xia Hu, Lu Wang, Xiao-Guang Qi, Jiangwei Lin, Guo-Jie Zhang, Wen Wang, Nengyin Sheng, Dong-Dong Wu
Although continual expansion of the brain during primate evolution accounts for our enhanced cognitive capabilities, the drivers of brain evolution have scarcely been explored in these ancestral nodes. Here we performed large-scale comparative genomic, transcriptomic and epigenomic analyses to investigate the evolutionary alterations acquired by brain genes, and provide comprehensive listings of innovatory genetic elements along the evolutionary path from ancestral primates to human. The regulatory sequences associated with brain-expressed genes experienced rapid change, particularly in the ancestor of the Simiiformes...
July 26, 2023: Molecular Biology and Evolution
https://read.qxmd.com/read/37446376/hypoxia-treatment-of-adipose-mesenchymal-stem-cells-promotes-the-growth-of-dermal-papilla-cells-via-hif-1%C3%AE-and-erk1-2-signaling-pathways
#39
JOURNAL ARTICLE
Qing Wang, Mei Zhou, Hongyan Zhang, Zhuang Hou, Dongjun Liu
Dermal papilla cells (DPCs) cultured in vitro induce hair follicle formation. Using a hypoxic microenvironment to culture adipose mesenchymal stem cells (ADSCs) can promote hair follicle growth. However, the exact molecular mechanisms underlying this process remain unclear. In this study, ADSCs and DPCs from Arbas Cashmere goats were used. A hypoxic microenvironment promoted the proliferation of ADSCs and increased the pluripotency of ADSCs. The growth factors vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and platelet-derived growth factor (PDGF) were upregulated in ADSCs in the hypoxia-conditioned medium (Hypo-cm)...
July 7, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37396953/galectin-3-plays-an-important-role-in-bmp7-induced-cementoblastic-differentiation-of-human-periodontal-ligament-cells-by-interacting-with-extracellular-components
#40
JOURNAL ARTICLE
Min-Jeong Choi, Tae Min You, Young-Joo Jang
Human periodontal ligament stem cells (hPDLSCs) contain multipotent postnatal stem cells that differentiate into PDL progenitors, osteoblasts, and cementoblasts. Previously, we obtained cementoblast-like cells from hPDLSCs using bone morphogenetic protein 7 (BMP7) treatment. Differentiation into appropriate progenitor cells requires interactions and changes between stem or progenitor cells and their so-called environment niches, and cell surface markers play an important role. However, cementoblast-specific cell surface markers have not yet been fully studied...
2023: Stem Cells International
keyword
keyword
72672
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.