Quy Le, Sommer Castro, Thao Tang, Anisha M Loeb, Tiffany Hylkema, Cyd Nourigat McKay, LaKeisha Perkins, Shivani Srivastava, Lindsey Call, Jenny Smith, Amanda Leonti, Rhonda Ries, Laura Pardo, Michael R Loken, Colin Correnti, Salvatore Fiorenza, Cameron J Turtle, Stanley Riddell, Katherine Tarlock, Soheil Meshinchi
PURPOSE: We previously identified mesothelin (MSLN) as highly expressed in a significant fraction of acute myeloid leukemia (AML) but entirely silent in normal hematopoiesis, providing a promising antigen for immunotherapeutic targeting that avoids hematopoietic toxicity. Given that T cells genetically modified to express chimeric antigen receptors (CAR) are effective at eradicating relapsed/refractory acute lymphocytic leukemia, we developed MSLN-directed CAR T cells for preclinical evaluation in AML...
October 15, 2021: Clinical Cancer Research