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https://www.readbyqxmd.com/read/28731059/optical-coherence-tomography-detection-of-characteristic-retinal-nerve-fiber-layer-thinning-in-nasal-hypoplasia-of-the-optic-disc
#1
M Haruta, R Kodama, R Yamakawa
PurposeTo determine the clinical usefulness of optical coherence tomography (OCT) for detecting thinning of the retinal nerve fiber layer (RNFL) in eyes with nasal hypoplasia of the optic discs (NHOD).Patients and methodsThe medical records of five patients (eight eyes) with NHOD were reviewed. The ratio of the disc-macula distance to the disc diameter (DM/DD) and the disc ovality ratio of the minimal to maximal DD were assessed using fundus photographs. The RNFL thicknesses of the temporal, superior, nasal, and inferior quadrants were evaluated using OCT quadrant maps...
July 21, 2017: Eye
https://www.readbyqxmd.com/read/28729419/the-exocyst-is-required-for-photoreceptor-ciliogenesis-and-retinal-development
#2
Glenn P Lobo, Diana Fulmer, Lilong Guo, Xiaofeng Zuo, Yujing Dang, Seok-Hyung Kim, Yanhui Su, Kola George, Elisabeth Obert, Ben Fogelgren, Deepak Nihalani, Russell A Norris, Bärbel Rohrer, Joshua H Lipschutz
We previously have shown that the highly-conserved eight-protein exocyst trafficking complex is required for ciliogenesis in kidney tubule cells. We hypothesized here that ciliogenic programs are conserved across organs and species. To determine if renal primary ciliogenic programs are conserved in the eye, and to characterize the function and mechanisms by which the exocyst regulates eye development in zebrafish, we focused on exoc5, a central component of the exocyst complex, by analyzing both exoc5 zebrafish mutants, and photoreceptor-specific Exoc5 knockout mice...
July 20, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28724826/bilateral-normal-tension-glaucoma-can-this-be-nutritional
#3
Sirisha Senthil, Kiranmaye Turaga
Normal tension glaucoma (NTG) also known as low tension glaucoma, presents with optic nerve head and visual field damage in the absence of high intraocular pressure (<21 mmHg). There are several patients of NTG seen in our clinics who have repeatable visual field defects, which may or may not correlate with the disc appearance, but are labeled as glaucoma. Ruling out ischemic, nutritional, and other causes of one-time damage are important before diagnosing an NTG. We report 3 such cases that were misdiagnosed and referred as NTG...
July 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28723747/injury-of-optic-radiation-and-visual-field-defect-in-a-patient-with-aneurysmal-subarachnoid-hemorrhage-a-case-report
#4
Sung Ho Jang, Jeong Pyo Seo
RATIONALE: Little is known about optic radiation (OR) injury following aneurysmal subarachnoid hemorrhage (SAH). In the current study, we report on a patient who showed a visual field defect and injury of the OR following aneurysmal SAH, using diffusion tensor tractography (DTT). PATIENT CONCERNS: At 4 weeks from onset, when a 62-year old female started rehabilitation, she complained of a visual field defect. Peripheral field defects were detected on both eyes using the Humphrey visual field test...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28713646/progression-of-local-glaucomatous-damage-near-fixation-as-seen-with-adaptive-optics-imaging
#5
Donald C Hood, Dongwon Lee, Ravivarn Jarukasetphon, Jason Nunez, Maria A Mavrommatis, Richard B Rosen, Robert Ritch, Alfredo Dubra, Toco Y P Chui
PURPOSE: Deep glaucomatous defects near fixation were followed over time with an adaptive optics-scanning light ophthalmoscope (AO-SLO) to better understand the progression of these defects and to explore the use of AO-SLO in detecting them. METHODS: Six eyes of 5 patients were imaged with an AO-SLO from 2 to 4 times for a range of 14.6 to 33.6 months. All eyes had open-angle glaucoma with deep defects in the superior visual field (VF) near fixation as defined by 10-2 VFs with 5 or more points less than -15 dB; two of the eyes had deep defects in the inferior VF as well...
July 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/28709200/frustrated-crystallization-of-a-monolayer-of-magnetized-beads-under-geometrical-confinement
#6
J Schockmel, N Vandewalle, E Opsomer, G Lumay
We present a systematic experimental study of the confinement effect on the crystallization of a monolayer of magnetized beads. The particles are millimeter-scale grains interacting through the short range magnetic dipole-dipole potential induced by an external magnetic field. The grains are confined by repulsing walls and are homogeneously distributed inside the cell. A two-dimensional (2d) Brownian motion is induced by horizontal mechanical vibrations. Therefore, the balance between magnetic interaction and agitation allows investigating 2d phases through direct visualization...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28698443/-medical-assistance-based-on-interviews-conducted-before-physician-examination-by-a-pharmacist-for-outpatients-with-thyroid-cancer-treated-with-lenvatinib
#7
Yuki Kawachi, Michio Kimura, Makiko Go, Masami Ohnishi, Tomoaki Yoshimura
In municipal hospitals, there are few cases of thyroid cancer for which the multi-kinase inhibitor lenvatinib is used. Moreover, there are very few reports of lenvatinib use. We examined interventions related to the use of lenvatinib made at the pharmaceutical outpatient clinic in our facility. Seven patients received lenvatinib. The prescription proposals from the pharmacist( 45 cases)provided advice on dosage(15.6%), discontinuation of medication(11.1%), supportive care(64.4%), and other advice(9.0%). The prescription acceptance rate was 84...
June 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28687871/chromatic-pupillography-in-hemianopia-patients-with-homonymous-visual-field-defects
#8
Fumiatsu Maeda, Carina Kelbsch, Torsten Straßer, Karolína Skorkovská, Tobias Peters, Barbara Wilhelm, Helmut Wilhelm
PURPOSE: The pupil light reflex is considered to be a simple subcortical reflex. However, many studies have proven that patients with isolated occipital lesions with homonymous hemianopia show pupillary hemihypokinesia. Our hypothesis is that the afferent pupillary system consists of two pathways: one via intrinsically photosensitive retinal ganglion cells (ipRGCs), the other running through the normal RGCs via the visual cortex. The purpose of this study was to test the hypothesis of these two separate pupillomotor pathways...
June 30, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28687846/comparison-of-the-retinal-microvascular-density-between-open-angle-glaucoma-and-nonarteritic-anterior-ischemic-optic-neuropathy
#9
Chun-Hsiu Liu, Wei-Chi Wu, Ming-Hui Sun, Ling-Yuh Kao, Yung-Sung Lee, Henry Shen-Lih Chen
Purpose: To compare optical coherence tomography angiography (OCT-A) retinal vasculature measurements between nonarteritic anterior ischemic optic neuropathy (NAION) and open angle glaucoma (OAG) with altitudinal hemifield visual field defects. Methods: This retrospective cross-sectional study included 10 NAION eyes and 16 OAG eyes, both demonstrating hemifield visual field defects, and 27 normal eyes serving as controls. The peripapillary and macular OCT-A scans were acquired...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28683479/-diagnostic-precision-of-the-confocal-scanning-laser-ophthalmoscopy-in-the-large-optic-disc-with-physiological-excavation-a-long-term-study
#10
Eva Charlotte Koch, Niklas Plange, Matthias Fuest, Hannah Schimitzek, David Kuerten
We repeatedly examined 17 subjects with presumed bilateral physiological excavation labeled as pathological and/or borderline via HRT to verify the diagnosis of physiological cupping or to monitor the long-term progression into normal tension glaucoma. Patients and Methods 17 Subjects with presumed bilateral physiological cupping and large optic discs were included in this long-term follow-up study. All subjects underwent regular detailed ophthalmologic examinations, including intraocular pressure measurement via Goldmann applanation tonometry (GAT), retinal nerve fiber layer imaging via optical coherence tonometry (OCT) and visual field testing and optic disc imaging using the HRT...
July 6, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28677953/direct-visualization-of-local-electromagnetic-field-structures-by-scanning-transmission-electron-microscopy
#11
Naoya Shibata, Scott D Findlay, Takao Matsumoto, Yuji Kohno, Takehito Seki, Gabriel Sánchez-Santolino, Yuichi Ikuhara
The functional properties of materials and devices are critically determined by the electromagnetic field structures formed inside them, especially at nanointerface and surface regions, because such structures are strongly associated with the dynamics of electrons, holes and ions. To understand the fundamental origin of many exotic properties in modern materials and devices, it is essential to directly characterize local electromagnetic field structures at such defect regions, even down to atomic dimensions...
July 5, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28676279/projection-resolved-optical-coherence-tomography-angiography-of-macular-retinal-circulation-in-glaucoma
#12
Hana L Takusagawa, Liang Liu, Kelly N Ma, Yali Jia, Simon S Gao, Miao Zhang, Beth Edmunds, Mansi Parikh, Shandiz Tehrani, John C Morrison, David Huang
PURPOSE: To detect macular perfusion defects in glaucoma using projection-resolved optical coherence tomography (OCT) angiography. DESIGN: Prospective observation study. PARTICIPANTS: A total of 30 perimetric glaucoma and 30 age-matched normal participants were included. METHODS: One eye of each participant was imaged using 6 × 6-mm macular OCT angiography (OCTA) scan pattern by 70-kHz 840-nm spectral-domain OCT. Flow signal was calculated by the split-spectrum amplitude-decorrelation angiography algorithm...
July 1, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28676014/citicoline-and-retinal-ganglion-cells-effects-on-morphology-and-function
#13
Vincenzo Parisi, Francesco Oddone, Lucia Ziccardi, Gloria Roberti, Gianluca Coppola, Gianluca Manni
Retinal ganglion cells (RGCs) are the nervous retinal elements that connect the visual receptors to the brain forming the nervous visual system. Functional and/or morphological involvement of RGCs occurs in several ocular and neurological disorders and therefore these cells are targeted in neuroprotective strategies. Cytidine 5-diphosphocholine or Citicoline is an endogenous compound that acts in the biosynthesis of phospholipids of cell membranes and increases neurotransmitters' levels in the Central Nervous System...
July 3, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28675066/inadequacy-of-self-assessment-of-vision-and-fitness-to-drive
#14
John Garfield
The author, a retired neurosurgeon then aged 81, describes his own right upper quadrantic homonymous visual field defect which did not impair any normal daily activities. His own occupation allowed him to recognise the defect. It is unlikely that such a defect would have been noticed by other elderly persons. The field defect shown by perimetry (illustrated) debarred him from driving. Self-assessment of visual acuity, and especially fields, is inadequate when applying for renewal of a driving licence. Effective steps to prevent such licensing and the damage that may follow are discussed...
January 1, 2017: Medico-legal Journal
https://www.readbyqxmd.com/read/28672913/amniotic-membrane-derived-stem-cells-help-repair-osteochondral-defect-in-a-weight-bearing-area-in-rabbits
#15
Zhijin Zhang, Linru Zeng, Jun Yang, Lin Guo, Qiao Hou, Fangbing Zhu
Our study evaluated the use of amniotic membrane-derived stem cells for repairing osteochondral defects in a weight-bearing area in rabbits. Twenty-four 3-month-old male or female New Zealand white rabbits were selected. The rabbits were randomly divided into 3 groups of eight, according to the treatment received for an experimentally inflicted femoral medial malleolus lesion, group I received a human acellular amniotic membrane seeded with bone marrow-derived mesenchymal stem cells (HAAM-BMSCs) implant; group II received a simple HAAM implant and the control group received no experimental lesion or treatment...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28669267/microsurgical-resection-of-a-high-grade-occipital-arteriovenous-malformation-after-staged-embolization
#16
Liyong Sun, Hongqi Zhang, Jian Ren
The authors demonstrate the case of a 16-year-old girl with a large symptomatic occipital arteriovenous malformation (AVM). The staged embolization was performed to downgrade the AVM from Spetzler-Martin (S-M) Grade IV (Supplementary S-M Grade 7) to Grade III (Supplementary S-M Grade 5). The patient developed a subacute progressive visual field defect after the final time of embolization. MRI revealed an enlarged draining venous ectasia of the AVM compressing the visual cortex. Postoperatively, good radiological results were achieved, and the patient reported an improvement in her symptoms...
July 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28669042/paravascular-inner-retinal-abnormalities-in-healthy-eyes
#17
Rie Osaka, Saki Manabe, Yukiko Miyoshi, Yuki Nakano, Ayana Yamashita, Chieko Shiragami, Kazuyuki Hirooka, Yuki Muraoka, Akitaka Tsujikawa
PURPOSE: To investigate the prevalence and characteristics of paravascular inner retinal abnormalities in healthy eyes. MATERIALS AND METHODS: In this prospective observational case series, we included 178 healthy eyes (178 patients) with no ocular diseases. Eyes with co-existing ocular diseases, e.g., epiretinal membrane, glaucoma, or high myopia, were excluded from the current study. The posterior pole and paravascular areas of the temporal arcade vessels were comprehensively examined by dense radial scanning of optical coherence tomography (OCT) with the extended field imaging technique...
July 2, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28663559/association-of-six1-six6-locus-polymorphisms-with-regional-circumpapillary-retinal-nerve-fibre-layer-thickness-the-nagahama-study
#18
Munemitsu Yoshikawa, Kenji Yamashiro, Hideo Nakanishi, Manabu Miyata, Masahiro Miyake, Yoshikatsu Hosoda, Yasuharu Tabara, Fumihiko Matsuda, Nagahisa Yoshimura
SIX1 and SIX6 are glaucoma susceptibility genes. Previous reports indicate that the single nucleotide polymorphism (SNP) rs33912345 in SIX6 is associated with inferior circumpapillary retinal nerve fibre layer (cpRNFL) thickness (cpRNFLT). Although the region of visual field defect in glaucoma patients is directly related to cpRNFL thinning, a detailed sector analysis has not been performed in genetic association studies. In the present study, we evaluated 26 tagging SNPs in the SIX1/SIX6 locus ±50 kb region in a population of 2,306 Japanese subjects with 4- and 32-sector cpRNFLT analysis...
June 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28661562/predictors-of-visual-outcome-in-patients-operated-for-craniopharyngioma-a-danish-national-study
#19
Mads Forslund Jacobsen, Ann Sofia Skou Thomsen, Daniella Bach-Holm, Ghazaleh Doroudian, Kamilla Rothe Nissen, Kåre Fugleholm, Lars Poulsgaard, Volkert Siersma, Steffen Heegaard
PURPOSE: Craniopharyngioma often causes visual loss due to the close relation to the anterior visual pathways. This study investigates the incidence and predictors of visual outcomes in patients with craniopharyngioma. METHODS: Data from sixty-six patients who underwent surgery for craniopharyngioma from 2009 to 2013 in Denmark were reviewed. Primary outcomes were visual acuity (VA) and visual field (VF) defects from pre-and postoperative visits. Secondary outcomes were optic nerve atrophy (OA) and papilledema...
June 29, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28660555/the-impact-of-visual-symptoms-on-the-quality-of-life-of-patients-with-early-to-moderate-glaucoma
#20
Young Shin Kim, Myeong Yeon Yi, Young Jae Hong, Ka Hee Park
PURPOSE: To investigate the visual symptoms and to determine the impact of visual symptoms on vision-related quality of life (QoL) in patients with early to moderate glaucoma. METHODS: A retrospective, hospital-based, cross-sectional study was conducted from July 1 to August 31, 2014, at a university referral center. A total of 176 patients with early to moderate glaucoma underwent a comprehensive ocular examination, including Humphrey visual field testing. The patients were divided into six groups based on visual symptoms that could be verified by forced-choice questions...
June 28, 2017: International Ophthalmology
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