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https://www.readbyqxmd.com/read/28105123/effect-of-anti-vegf-drugs-combined-with-photodynamic-therapy-in-the-treatment-of-age-related-macular-degeneration
#1
Yi Dong, Guangming Wan, Panshi Yan, Yue Chen, Wenzhan Wang, Guanghua Peng
We analyzed the effects of anti-vascular endothelial growth factor (VEGF) drugs combined with photodynamic therapy (PDT) in the treatment of age-related macular degeneration (AMD). Ninety-six cases (192 eyes) of AMD were included in this study and randomly divided into the observation group and control group (n=48 cases per group). The control group was administered the treatment of Lucentis intravitreal injection alone and the observation group was administered Lucentis combined with PDT. The therapeutic effects were compared...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28095478/evaluating-silent-reading-performance-with-an-eye-tracking-system-in-patients-with-glaucoma
#2
Noriaki Murata, Daiki Miyamoto, Tetsuya Togano, Takeo Fukuchi
OBJECTIVE: To investigate the relationship between silent reading performance and visual field defects in patients with glaucoma using an eye tracking system. METHODS: Fifty glaucoma patients (Group G; mean age, 52.2 years, standard deviation: 11.4 years) and 20 normal controls (Group N; mean age, 46.9 years; standard deviation: 17.2 years) were included in the study. All participants in Group G had early to advanced glaucomatous visual field defects but better than 20/20 visual acuity in both eyes...
2017: PloS One
https://www.readbyqxmd.com/read/28093631/-retinal-artery-occlusion
#3
N Feltgen, A Pielen
Retinal artery occlusion leads to profound visual impairment in the affected eye. It is rarely caused by local ophthalmic pathologies. Most patients present with a large number of cardio- and cerebrovascular risk factors. Visual loss is the leading symptom in central retinal artery occlusion (CRAO), whereas a circumscribed visual field defect is claimed in branch retinal artery occlusion (BRAO). Although many attempts have been made to improve the course of the disease, no effective therapy is available. There is some hope that intravenous fibrinolysis could influence the natural course but the therapeutic window is small (ca...
January 16, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28091597/direct-visualization-of-hydrogen-absorption-dynamics-in-individual-palladium-nanoparticles
#4
Tarun C Narayan, Fariah Hayee, Andrea Baldi, Ai Leen Koh, Robert Sinclair, Jennifer A Dionne
Many energy storage materials undergo large volume changes during charging and discharging. The resulting stresses often lead to defect formation in the bulk, but less so in nanosized systems. Here, we capture in real time the mechanism of one such transformation-the hydrogenation of single-crystalline palladium nanocubes from 15 to 80 nm-to better understand the reason for this durability. First, using environmental scanning transmission electron microscopy, we monitor the hydrogen absorption process in real time with 3 nm resolution...
January 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28079654/retinal-oximetry-in-subjects-with-glaucomatous-hemifield-asymmetry
#5
Zhu Li Yap, Charles Ong, Yi Fang Lee, Andrew Tsai, Clarissa Cheng, Monisha E Nongpiur, Shamira A Perera
PURPOSE: Although some studies suggest a strong link between retinal vessel oxygenation and damage to the retinal nerve fiber layer (RNFL) seen in glaucoma, it has yet to be conclusively proven. This study compares intraocular retinal oximetry in glaucomatous eyes displaying asymmetrically affected hemifields across different subgroups of glaucoma, namely primary angle closure glaucoma (PACG), primary open-angle glaucoma (POAG), and normal tension glaucoma (NTG). METHODS: In this prospective cross-sectional study, 99 patients (PACG, n=28; POAG, n=37; NTG, n=34) underwent retinal oxygenation and vessel caliber measurements using the Oxymap T1 Retinal Oximeter, Cirrus optical coherence tomography, and Humphrey visual field testing...
January 10, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28073365/neurophthalmological-conditions-mimicking-glaucomatous-optic-neuropathy-analysis-of-the-most-common-causes-of-misdiagnosis
#6
Diego Torres Dias, Michele Ushida, Roberto Battistella, Syril Dorairaj, Tiago Santos Prata
BACKGROUND: To analyze the most common neurophthalmological conditions that may mimic glaucomatous optic neuropathy and to determine which most often lead to misdiagnosis when evaluated by a glaucoma specialist. METHODS: We reviewed the charts of consecutive patients with optic neuropathies caused by neurophthalmological conditions screened in a single Eye Clinic within a period of 24 months. Within these enrolled patients, we selected the eyes whose fundoscopic appearance could resemble glaucoma based in pre-defined criteria (vertical cup-to-disc ratio ≥0...
January 10, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28072615/retinal-detachment-associated-with-peripapillary-staphyloma-imaged-with-swept-source-optical-coherence-tomography
#7
Daisuke Kunita, Makoto Inoue, Takashi Koto, Akito Hirakata
PURPOSE: To examine a rhegmatogenous retinal detachment (RRD) associated with a peripapillary staphyloma with swept source optical coherence tomography (SS-OCT) before and after vitrectomy and circumferential photocoagulation. METHODS: The SS-OCT images including the montage images of two patients with a RRD associated with peripapillary staphylomas were analyzed. A 34-year-old woman (Case 1) and a 70-year-old woman (Case 2) both noticed temporal visual field defects in their left eyes...
January 9, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28068662/evaluation-of-the-macular-ganglion-cell-inner-plexiform-layer-and-the-circumpapillary-retinal-nerve-fiber-layer-in-early-to-severe-stages-of-glaucoma-correlation-with-central-visual-function-and-visual-field-indexes
#8
Maria Pilar Bambo, Noemi Güerri, Blanca Ferrandez, Beatriz Cameo, Isabel Fuertes, Vicente Polo, Elena Garcia-Martin
OBJECTIVES: To compare the circumpapillary retinal nerve fiber layer (cpRNFL) and the macular ganglion cell-inner plexiform layer (GCIPL) in glaucoma patients at different disease stages and to evaluate correlations between optical coherence tomography (OCT) parameters with central visual function and visual field (VF) indexes. PATIENTS AND METHODS: One hundred forty patients were included in this prospective cross-sectional study. Subjects diagnosed with chronic open-angle glaucoma and 20/40 or better vision were recruited and classified as having early, moderate, or severe VF defects based on Hodapp-Parrish-Anderson criteria...
January 10, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28068370/visualization-of-radial-peripapillary-capillaries-using-optical-coherence-tomography-angiography-the-effect-of-image-averaging
#9
Shelley Mo, Erika Phillips, Brian D Krawitz, Reena Garg, Sarwat Salim, Lawrence S Geyman, Eleni Efstathiadis, Joseph Carroll, Richard B Rosen, Toco Y P Chui
OBJECTIVES: To assess the effect of image registration and averaging on the visualization and quantification of the radial peripapillary capillary (RPC) network on optical coherence tomography angiography (OCTA). METHODS: Twenty-two healthy controls were imaged with a commercial OCTA system (AngioVue, Optovue, Inc.). Ten 10x10° scans of the optic disc were obtained, and the most superficial layer (50-μm slab extending from the inner limiting membrane) was extracted for analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28059864/a-giant-tumefactive-virshow-robin-space-a-rare-cause-of-a-homonymous-quadrantanopia
#10
Alysse Rivet, Anne-Sophie Gauthier, Marion Chatain, Romain Billon-Grand, Laurent Thines, Bernard Delbosc
A 53-year-old woman was found to have a left inferior homonymous quadrantanopia. Brain MRI disclosed a giant Virchow-Robin space compressing the right optic tract. After fenestration of this cystic lesion, most of the visual field loss resolved. Giant Virchow-Robin spaces may cause homonymous field defects which, with appropriate management, may improve.
January 4, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28058169/idiopathic-isolated-cilioretinal-artery-occlusion-treated-with-hyperbaric-oxygen-therapy
#11
Serdar Aktaş, Osman Murat Uyar, Erol Özer, Hatice Aktaş, Kadir Eltutar
Cilioretinal artery occlusion (CLRAO) is a rare event which has been reported in association with various systemic diseases. We report a case of idiopathic isolated CLRAO treated successfully with hyperbaric oxygen (HBO) therapy. A 26-year-old man presented with sudden, painless vision loss and an inferior hemivisual field defect in the left eye. Fundus fluorescein angiography revealed an occluded cilioretinal artery. After 2 weeks of HBO therapy, visual acuity improved from 20/200 to 20/20. The visual field defect improved...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28050324/prevalence-of-split-nerve-fiber-layer-bundles-in-healthy-people-imaged-with-spectral-domain-optical-coherence-tomography
#12
Sirel Gür Güngör, Ahmet Akman, Almila Sarıgül Sezenöz, Gülşah Tanrıaşıkı
OBJECTIVES: The presence of retinal nerve fiber layer (RNFL) split bundles was recently described in normal eyes scanned using scanning laser polarimetry and by histologic studies. Split bundles may resemble RNFL loss in healthy eyes. The aim of our study was to determine the prevalence of nerve fiber layer split bundles in healthy people. MATERIALS AND METHODS: We imaged 718 eyes of 359 healthy persons with the spectral domain optical coherence tomography in this cross-sectional study...
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28048887/su-f-i-18-altered-visual-cortex-responses-by-wide-view-fmri-in-primary-open-angle-glaucoma-patients
#13
W Zhou, E Muir, S Chalfin, K Nagi, G Clarke, T Duong
PURPOSE: Primary open-angle glaucoma (POAG) is a common ocular disorder with progressive retinal ganglion cell loss. This study explored the application of wide view fMRI to evaluate neural activity of the whole visual cortex and its relation with visual field functions in POAG patients. METHODS: Nine subjects with diagnosed POAG (age: 59.9±10.9 y.o., 4 males) and nine age-matched healthy volunteers (age: 58.0±4.6 y.o., 6 males) were scanned on a 3T Siemens scanner...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28033298/retinal-and-choroidal-oxygen-saturation-of-the-optic-nerve-head-in-open-angle-glaucoma-subjects-by-multispectral-imaging
#14
Gai-Yun Li, Samer Abdo Al-Wesabi, Hong Zhang
The aim of this study was to determine whether differences exist in oxygen supply to the optic nerve head (ONH) from the retinal and choroidal vascular layers in patients with primary open angle glaucoma (POAG) using multispectral imaging (MSI).This ia an observational, cross-sectional study.Multispectral images were acquired from 38 eyes of 19 patients with POAG, and 42 healthy eyes from 21 matched volunteers with Annidis' RHA multispectral digital ophthalmoscopy. Superficial and deeper oxygen saturation of the optic disc was represented by the mean gray scale values on the retinal and choroidal oxy-deoxy maps, respectively...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28032805/nerve-fiber-layer-thickness-and-characteristics-associated-with-glaucoma-in-community-living-older-adults-prelude-to-a-screening-trial
#15
Barbara E K Klein, Chris A Johnson, Stacy M Meuer, Kyungmoo Lee, Andreas Wahle, Kristine E Lee, Amruta Kulkarni, Milan Sonka, Michael D Abràmoff, Ronald Klein
PURPOSE: To examine the associations of nerve fiber layer (NFL) thickness with other ocular characteristics in older adults. METHODS: Participants in the Beaver Dam Eye Study (2008-2010) underwent spectral domain optical coherence tomography (SD-OCT) scans of the optic nerve head, imaging of optic discs, frequency doubling technology (FDT) perimetry, measurement of intraocular pressure (IOP), and an interview concerning their history of glaucoma and use of drops to lower eye pressure...
December 29, 2016: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28028959/comparison-of-visual-field-measurement-with-heidelberg-edge-perimeter-and-humphrey-visual-field-analyzer-in-patients-with-ocular-hypertension
#16
Kamil Kaczorowski, Małgorzata Mulak, Dorota Szumny, Marta Baranowska, Joanna Jakubaszko-Jabłońska, Marta Misiuk-Hojło
BACKGROUND: Glaucoma is a group of eye diseases which result in damage to the optic nerve and vision loss. The most important examination in glaucoma patients is visual field assessment. One of the newer perimeters is Heidelberg Edge Perimeter (HEP). OBJECTIVES: The aim of the study was to compare visual field measurements made with Humphrey II 740 Visual Field (Carl Zeiss Meditec) and Heidelberg Edge Perimeter (HEP) (Heidelberg Engineering). FDF stimulus (flicker defined form) in HEP stimulates magnocellular retinal cells, which are the first to be damaged in the early stage of glaucoma...
September 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28009747/multicenter-prospective-longitudinal-study-of-the-recurrence-surgical-site-infection-and-quality-of-life-after-contaminated-ventral-hernia-repair-using-biosynthetic-absorbable-mesh-the-cobra-study
#17
Michael J Rosen, Joel J Bauer, Marco Harmaty, Alfredo M Carbonell, William S Cobb, Brent Matthews, Matthew I Goldblatt, Don J Selzer, Benjamin K Poulose, Bibi M E Hansson, Camiel Rosman, James J Chao, Garth R Jacobsen
OBJECTIVE: The aim of the study was to evaluate biosynthetic absorbable mesh in single-staged contaminated (Centers for Disease Control class II and III) ventral hernia (CVH) repair over 24 months. BACKGROUND: CVH has an increased risk of postoperative infection. CVH repair with synthetic or biologic meshes has reported chronic biomaterial infections and high hernia recurrence rates. METHODS: Patients with a contaminated or clean-contaminated operative field and a hernia defect at least 9 cm had a biosynthetic mesh (open, sublay, retrorectus, or intraperitoneal) repair with fascial closure (n = 104)...
January 2017: Annals of Surgery
https://www.readbyqxmd.com/read/27998453/-clinical-features-of-neurosyphilis-with-optic-neuritis-as-an-initial-finding
#18
S S Cao, H Y Li, Q G Xu, S Y Tan, S H Wei
Objective: To study the characteristics of neurosyphilis with optic neuritis as an initial finding. Methods: Retrospective analysis of clinical data and laboratory testing results of 16 cases (27 eyes) with optic neuritis as an initial finding of neurosyphilis from October 2010 to March 2015 in General Hospital of People's Liberation Army was made. Results: Six-teen patients (12 males, 4 females) were collected, the median age of patients was 47 (range 33 to 65) years ,the mean age was (49.63±9.05) years. Treponema pallidum particle agglutination assay (TPPA) analysis was positive in all of the patients and rapid plasma reagin (RPR) test was positive in 14 patients (2 patients did not test)...
December 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27996202/long-term-evolution-of-superficial-optic-disc-drusen
#19
Lasse Malmqvist, Henrik Lund-Andersen, Steffen Hamann
PURPOSE: Optic disc drusen (ODD) is hyaline deposits in the optic nerve head seen in 1-2% of the population. Long-term evolution of ODD anatomy and visual field defects in ODD patients is a key factor for learning more about pathophysiology and prognosis of the condition. With a median follow-up period of 56 years, this is the first study that evaluates superficial optic disc anatomy and visual fields in patients with ODD over a life span. METHODS: Observational case series investigating progression of superficial optic disc anatomy and visual fields in ODD patients...
December 20, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27993590/prevalence-of-anti-retinal-antibodies-in-acute-zonal-occult-outer-retinopathy-azoor-a-comprehensive-review-of-25-cases
#20
Cynthia X Qian, Angeline Wang, David L DeMill, Thiran Jayasundera, Kari Branham, Maria Fernanda Abalem, Naheed Khan, John R Heckenlively
PURPOSE: To perform a comprehensive review and to investigate the presence and role of autoimmune antibodies in 25 cases of acute zonal occult outer retinopathy (AZOOR) identified using the classification originally proposed by J.Donald Gass. DESIGN: Observational case series METHODS: Setting: Institutional Study Population: Twenty-five patients were identified by characteristic symptoms (abrupt onset of photopsias, followed by large scotomata at or connected to the blind spot), ocular findings (paucity of pigmentary changes with no sign of vitreous inflammation and abnormal electroretinogram in at least one eye,) and a negative family history for retinitis pigmentosa...
December 16, 2016: American Journal of Ophthalmology
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