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https://www.readbyqxmd.com/read/28079022/lifitegrast-for-the-treatment-of-dry-eye-disease-results-of-a-phase-iii-randomized-double-masked-placebo-controlled-trial-opus-3
#1
Edward J Holland, Jodi Luchs, Paul M Karpecki, Kelly K Nichols, Mitchell A Jackson, Kenneth Sall, Joseph Tauber, Monica Roy, Aparna Raychaudhuri, Amir Shojaei
PURPOSE: Lifitegrast is a lymphocyte function-associated antigen-1 antagonist developed to reduce inflammation in dry eye disease (DED). We report the results of OPUS-3 (NCT02284516), a phase III study evaluating the efficacy and safety of lifitegrast versus placebo in participants with DED. DESIGN: Twelve-week, phase III, randomized, double-masked, multicenter, placebo-controlled study. PARTICIPANTS: Adults aged ≥18 years with Schirmer tear test (without anesthesia) ≥1 and ≤10 mm, corneal fluorescein staining score ≥2...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/28077823/association-of-health-symptoms-with-low-level-exposure-to-organophosphates-dna-damage-ache-activity-and-occupational-knowledge-and-practice-among-rice-corn-and-double-crop-farmers
#2
Surat Hongsibsong, Nalin Sittitoon, Ratana Sapbamrer
OBJECTIVES: This study aims to determine (1) total dialkylphosphate (ΣDAP) levels, occupational knowledge and practice, DNA damage, AChE activity, and health symptoms in rice, corn, and double-crop farmers; (2) the association of health symptoms with ΣDAP levels, occupational knowledge and practice, DNA damage, and AChE activity in farmers; and (3) the prevalence of health symptoms between farmers and non-farmers. METHODS: A cross-sectional study was conducted by interviewing as well as analyzing urine and blood samples during July to August 2014...
January 11, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28072590/incorporating-the-patient-s-perspective-in-outcomes-research
#3
Betty Hsiao, Liana Fraenkel
PURPOSE OF REVIEW: Incorporation of the patients' perspective in clinical research is critical to ensure that outcomes measured reflect those, which matter most to patients. This review summarizes recent efforts to include the patients' perspective in the development of outcome measures and the importance of encouraging patient participation in decision-making and self-management. RECENT FINDINGS: Since the inclusion of fatigue as a patient-endorsed core outcome measure in rheumatoid arthritis (RA) trials, OMERACT has been instrumental in advocating for patient involvement in the development of core domains and instruments; current endeavors include cultivating an understanding of remission through the eyes of patients and gaining a sense of how to measure features of pain and 'stiffness' deemed as important to patients...
January 7, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28068454/non-surgical-interventions-for-acute-internal-hordeolum
#4
REVIEW
Kristina Lindsley, Jason J Nichols, Kay Dickersin
BACKGROUND: A hordeolum is a common, painful inflammation of the eyelid margin that is usually caused by a bacterial infection. The infection affects oil glands of the eyelid and can be either internal or external. In many cases, the lesion drains spontaneously and resolves without treatment; however, the inflammation can spread to other ocular glands or tissues, and recurrences are common. If unresolved, an acute internal hordeolum can become chronic, or can develop into a chalazion...
January 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28062426/tuberculous-scleral-abscess-with-choroidal-detachment
#5
Swapnil Madhukar Parchand, Aswanthi Sadesh Kumar, Subashini Kaliaperumal, Renuka Srinivasan
We present a case of ocular tuberculosis (TB) presenting as scleral abscess with choroidal detachment. A 60-year-old woman presented with intense pain, redness, watering and decreased vision in the right eye (RE) for 1 week duration. Slit lamp examination of RE revealed diffuse scleritis with two pus-pointing areas in the supero-temporal quadrant suggesting scleral abscess. Fundus examination of the RE showed choroidal detachment in the temporal and inferior quadrant. Left eye examination was unremarkable...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28060551/scleritis-associated-with-sapho-syndrome-a-case-report
#6
Rie Tanaka, Keiichi Sakurai, Toshikatsu Kaburaki
A 31-year-old woman developed bilateral painful red eyes. A slit-lamp examination revealed anterior diffuse scleritis. She had been diagnosed with palmoplantar pustulosis 2 years before. Further evaluation revealed hyperostosis of the sacroiliac joint and inflammation of the bilateral sternoclavicular joints and right sternocostal joint. Ultimately, she was diagnosed with SAPHO syndrome by rheumatologists after excluding other causative diseases. Scleritis associated with SAPHO syndrome is relatively uncommon...
January 6, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28060148/short-term-safety-of-2-mg-intravitreal-ziv-aflibercept
#7
Jay Chhablani, Chintan Jethalal Dedhia, Hari K Peguda, Michael Stewart
PURPOSE: To evaluate the safety of single intravitreal 2 mg ziv-aflibercept (0.08 mL) injections for the treatment of choroidal neovascular membranes (CNVM). METHODS: Eyes with choroidal neovascular membranes because of several conditions each received single intravitreal injections of 2 mg ziv-aflibercept (0.08 mL). Comprehensive ophthalmic examinations and detailed systemic evaluations were performed at baseline and Days 1, 7, and 30 after injections. Standard electroretinography was performed at baseline and Day 30...
January 2, 2017: Retina
https://www.readbyqxmd.com/read/28060062/pilot-study-of-corneal-sensitivity-and-its-association-in-keratoconus
#8
Preeji S Mandathara, Fiona J Stapleton, Jim Kokkinakis, Mark D P Willcox
PURPOSE: To evaluate corneal sensitivity and its association with other clinical parameters in keratoconus. METHODS: Twenty-four subjects with keratoconus aged between 18 and 65 years were recruited in this cross-sectional study. Ocular symptoms, corneal topography, tear variables such as tear osmolarity, volume and lower tear meniscus height, ocular surface staining, central sensitivity threshold (CST), and corneal subepithelial nerve mapping were obtained. Association between central CST and other clinical variables was examined using the Spearman correlation coefficient...
February 2017: Cornea
https://www.readbyqxmd.com/read/28058148/pain-perception-in-phacoemulsification-with-topical-anesthesia-and-evaluation-of-factors-related-with-pain
#9
Zeynep Dadacı, Mehmet Borazan, Nurşen Öncel Acır
OBJECTIVES: Evaluation of pain during and after phacoemulsification with topical anesthesia in patients with senile cataract and investigation of factors related with pain. MATERIALS AND METHODS: Ninety-two adult patients scheduled for routine clear corneal phacoemulsification with topical anesthesia who had no previous cataract surgery in their fellow eyes were included in the study. Verbal pain scale and visual analog scale were used to measure pain intensity...
August 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28057642/accelerated-transepithelial-corneal-cross-linking-for-progressive-keratoconus-a-prospective-study-of-12%C3%A2-months
#10
Wei Aixinjueluo, Tomohiko Usui, Takashi Miyai, Tetsuya Toyono, Toshihiro Sakisaka, Satoru Yamagami
BACKGROUND/AIMS: To evaluate the clinical results of accelerated transepithelial corneal cross-linking (CXL) in Japanese patients with progressive keratoconus (KCN). METHODS: Thirty eyes of 19 patients (16 male, 3 female patients) with progressive KCN were included. The mean age was 24.9±7.0 (range 16-38) years. All patients received ultraviolet A radiation for 3 min at an irradiance of 30 mW/cm(2). Patients were followed up on the first day, at 1 week and 2 weeks, and at 1 month, 3 months, 6 months and 12 months postoperatively...
January 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28050051/discordant-dry-eye-disease-an-american-ophthalmological-society-thesis
#11
Roni M Shtein, Daniel E Harper, Vincent Pallazola, Steven E Harte, Munira Hussain, Alan Sugar, David A Williams, Daniel J Clauw
PURPOSE: To improve understanding of dry eye disease and highlight a subgroup of patients who have a component of central sensitization and neuropathic pain contributing to their condition. METHODS: Prospective, cross-sectional, IRB-approved study comparing isolated dry eye disease (n=48) to fibromyalgia (positive control; n=23) and healthy (negative control; n=26) individuals with ocular surface examination, corneal confocal microscopy, quantitative sensory testing, and self-reported ocular symptoms and systemic associations...
August 2016: Transactions of the American Ophthalmological Society
https://www.readbyqxmd.com/read/28047547/su-f-t-647-linac-based-stereotactic-radiosurgery-srs-in-the-treatment-of-trigeminal-neuralgia-detailed-description-of-srs-procedural-technique-and-reported-clinical-outcomes
#12
D Pokhrel, S Sood, R Badkul, H Jiang, T Stepp, P Camarata, F Wang
PURPOSE: SRS is an effective non-invasive alternative treatment modality with minimal-toxicity used to treat patients with medically/surgically refractory trigeminal neuralgia root(TNR) or those who may not tolerate surgical intervention. We present our linac-based SRS procedure for TNR treatment and simultaneously report our clinical outcomes. METHODS: Twenty-eight TNR-patients treated with frame-based SRS at our institution (2009-2015) with a single-fraction point-dose of 60-80Gy to TNR were included in this IRB-approved study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042094/bulbar-conjunctival-microvascular-responses-in-dry-eye
#13
Wan Chen, Hatim Ismail M Batawi, Jimmy R Alava, Anat Galor, Jin Yuan, Constantine D Sarantopoulos, Allison L McClellan, William J Feuer, Roy C Levitt, Jianhua Wang
PURPOSE: Conjunctival microvascular responses may be a surrogate metric of efferent neural pathway function innervating the ocular surface as changes in blood flow occur within seconds after a stimulus. As somatosensory dysfunction may partially underlie dry eye (DE), in this study we evaluate whether bulbar conjunctival microvascular alterations correlate with various aspects of DE. METHODS: Fifty-six DE patients were prospectively recruited from a Veterans Affairs ophthalmology clinic over an 11-month period...
December 29, 2016: Ocular Surface
https://www.readbyqxmd.com/read/28039596/optic-neuritis-secondary-to-antiandrogen-therapy
#14
REVIEW
Á Ní Mhéalóid, G Cunniffe
BACKGROUND: Optic neuropathy is a disorder characterised by dysfunction or destruction of the optic nerve tissues. Acquired causes include interruption in the blood supply, nutritional deficiency, compression by a tumour or aneurysm, trauma, and toxic types (Ambizas and Patel In US Pharm 36(4):HS2-HS6, 1). Drug-induced optic neuropathy is of the toxic type and can be defined as a clinical syndrome characterised by papillomacular bundle damage, central, or cecocentral scotoma, and reduced colour vision (Ambizas and Patel In US Pharm 36(4):HS2-HS6, 2011; Sharma and Sharma In Indian J Ophthalmol 59(2):137-141, 2)...
December 30, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28039367/efficacy-and-safety-results-of-abt-414-in-combination-with-radiation-and-temozolomide-in-newly-diagnosed-glioblastoma
#15
David A Reardon, Andrew B Lassman, Martin van den Bent, Priya Kumthekar, Ryan Merrell, Andrew M Scott, Lisa Fichtel, Erik P Sulman, Erica Gomez, JuDee Fischer, Ho-Jin Lee, Wijith Munasinghe, Hao Xiong, Helen Mandich, Lisa Roberts-Rapp, Peter Ansell, Kyle D Holen, Hui K Gan
BACKGROUND: The purpose of this study was to determine the maximum tolerated dose (MTD), recommended phase II dose (RPTD), safety, and pharmacokinetics of ABT-414 plus radiation and temozolomide in newly diagnosed glioblastoma. ABT-414 is a first-in-class, tumor-specific antibody-drug conjugate that preferentially targets tumors expressing overactive epidermal growth factor receptor (EGFR). METHODS: In this multicenter phase I study, patients received 0.5-3.2 mg/kg ABT-414 every 2 weeks by intravenous infusion...
December 29, 2016: Neuro-oncology
https://www.readbyqxmd.com/read/28035695/effects-of-low-energy-shock-wave-therapy-on-inflammatory-moleculars-bladder-pain-and-bladder-function-in-a-rat-cystitis-model
#16
Hung-Jen Wang, Wei-Chia Lee, Pradeep Tyagi, Chao-Cheng Huang, Yao-Chi Chuang
AIMS: Low energy shock wave (LESW) is known to facilitate tissue regeneration with analgesic and anti-inflammatory effects. We examined the effects of LESW on the expression of inflammatory molecules, pain behavior, and bladder function in a rat cystitis model. METHODS: Control and experimental animals were injected with saline or cyclophosphamide (CYP; 75 mg/kg intraperitoneally) on day 1 and 4. After lower midline incision, the bladders were exposed to LESW (300 pulses, 0...
December 30, 2016: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28034977/which-facial-descriptors-do-care-home-nurses-use-to-infer-whether-a-person-with-dementia-is-in-pain
#17
Stefan Lautenbacher, Elizabeth L Sampson, Sonja Pähl, Miriam Kunz
OBJECTIVES : Pain assessment in people with advanced dementia relies strongly on observable pain behaviors, such as facial expressions, body movement, and vocalizations. However, the process of inferring pain in others based on such observations is not well understood. We aimed to investigate which features of facial expressions caregivers rely on when inferring the presence and intensity of pain in people with dementia. METHODS : A questionnaire, including items on 13 facial descriptors, which were extracted from established observational scales for pain in dementia, was sent to 366 nursing homes in Germany...
December 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28033436/acute-eye-pain-following-prolonged-face-down-positioning-in-a-patient-with-marfan-syndrome
#18
Megan N Scott, Christina Y Weng
No abstract text is available yet for this article.
December 29, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28031698/phototherapeutic-keratectomy-for-epithelial-basement-membrane-dystrophy
#19
Wen-Shin Lee, Carson K Lam, Edward E Manche
PURPOSE: The purpose of this study was to evaluate the long-term efficacy of phototherapeutic keratectomy (PTK) in treating epithelial basement membrane dystrophy (EBMD). METHODS: Preoperative and postoperative records were reviewed for 58 eyes of 51 patients with >3 months follow-up (range 3-170 months) treated for EBMD with PTK after failure of conservative medical treatment at Byers Eye Institute of Stanford University. Symptoms, clinical findings, and corrected distance visual acuity (CDVA) were assessed...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28031146/visual-perspective-during-remembering-erp-evidence-of-familiarity-based-source-monitoring
#20
P Andrew Leynes, Ben Askin, Joshua D Landau
Autobiographical recollections are accompanied by visual perspectives that can be either a view through the person's own eyes (first-person) or a view that integrates visual characteristics of the rememberer into the reconstructed scene (third-person). Some have argued that a third-person perspective serves as a coping mechanism allowing the person to distance themselves from details of painful memories. The study reported here created first- and third-person memories in a novel experimental paradigm. Later, participants discriminated between these perspectives on a source memory test while event-related potentials (ERPs) were recorded...
December 10, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
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