keyword
https://read.qxmd.com/read/38533432/nicotinamide-ribose-ameliorates-myocardial-ischemia-reperfusion-injury-by-regulating-autophagy-and-regulating-oxidative-stress
#21
JOURNAL ARTICLE
Chen Yuan, Heng Yang, Wanqi Lan, Juesheng Yang, Yanhua Tang
Nicotinamide riboside (NR) has been reported to play a protective role in myocardial ischemia-reperfusion (I/R) injury when used in association with other drugs; however, the individual effect of NR is unknown. In the present study Evan's blue/triphenyl tetrazolium chloride staining, hematoxylin and eosin staining, echocardiography, western blotting, reverse transcription-quantitative PCR, and the detection of myocardial injury-associated markers and oxidative stress metabolites were used to explore the ability of NR to alleviate cardiac I/R injury and the relevant mechanisms of action...
May 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38532915/commonly-used-diagnostic-label-classes-domain-and-formulation-among-nursing-students-in-ibadan-oyo-state-nigeria
#22
JOURNAL ARTICLE
Iyanuoluwa O Ojo, Elizabeth O Kazeem, Olufemi O Oyediran, Timothy O Oladosu, Adenike A Olaogun, Prisca O Adejumo
BACKGROUND: In order to select nursing actions that will produce the desired results, a nursing diagnosis is crucial. Despite this, it can be challenging for nursing students to recognize and create precise nursing diagnostic labels that are particular to a patient's situation. The study's objectives are to identify the diagnostic labels, classes, and domains that are frequently formulated by nursing students. MATERIALS AND METHODS: A descriptive cross-sectional methodology and a self-developed questionnaire were utilized to gather information from 120 nursing students who were chosen using a simple random sampling technique...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38532523/comparing-the-effects-of-various-%C3%AE-blockers-on-cardiovascular-mortality-in-breast-cancer-patients
#23
JOURNAL ARTICLE
Mantasha Tabassum, Soumya G Chikermane, Camille Johnson, Noor M Abdulkareem, Elisabeth M Wang, Michael L Johnson, Meghana V Trivedi
BACKGROUND: Cardiovascular (CV) disease is a leading cause of death in breast cancer (BC) patients due to the increased age and treatments. While individual β-blockers have been investigated to manage CV complications, various β-blockers have not been compared for their effects on CV death in this population. We aimed to compare CV mortality in older BC patients taking one of the commonly used β-blockers. METHODS: This retrospective cohort study was conducted using the Surveillance, Epidemiology and End Results (SEER) - Medicare data (2010-2015)...
March 26, 2024: Cardio-Oncology
https://read.qxmd.com/read/38532366/emerging-roles-of-prominin-1-cd133-in-the-dynamics-of-plasma-membrane-architecture-and-cell-signaling-pathways-in-health-and-disease
#24
REVIEW
Petr Pleskač, Christine A Fargeas, Renata Veselska, Denis Corbeil, Jan Skoda
Prominin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively associated with highly curved and prominent membrane structures. It is widely recognized as an antigenic marker of stem cells and cancer stem cells and is frequently used to isolate them from biological and clinical samples. Recent progress in understanding various aspects of CD133 biology in different cell types has revealed the involvement of CD133 in the architecture and dynamics of plasma membrane protrusions, such as microvilli and cilia, including the release of extracellular vesicles, as well as in various signaling pathways, which may be regulated in part by posttranslational modifications of CD133 and its interactions with a variety of proteins and lipids...
March 26, 2024: Cellular & Molecular Biology Letters
https://read.qxmd.com/read/38532238/pharmacological-basis-of-differences-in-dose-response-dose-equivalence-and-duration-of-action-of-inhaled-corticosteroids
#25
JOURNAL ARTICLE
Peter T Daley-Yates, Bhumika Aggarwal, Maximilian Plank
INTRODUCTION: Asthma treatment guidelines classify inhaled corticosteroid (ICS) regimens as low, medium, or high dose. However, efficacy and safety are not independently assessed accordingly. Moreover, differences in ICS duration of action are not considered when a dose regimen is selected. We investigated the efficacy and safety implications of these limitations for available ICS molecules. METHODS: Published pharmacodynamic and pharmacokinetic parameters were used, alongside physiological and pharmacological principles, to estimate the efficacy and safety of available ICS molecules...
March 27, 2024: Advances in Therapy
https://read.qxmd.com/read/38532069/sitagliptin-elevates-plasma-and-csf-incretin-levels-following-oral-administration-to-nonhuman-primates-relevance-for-neurodegenerative-disorders
#26
JOURNAL ARTICLE
Yazhou Li, Kelli L Vaughan, Yun Wang, Seong-Jin Yu, Eun-Kyung Bae, Ian A Tamargo, Katherine O Kopp, David Tweedie, Cheng-Chuan Chiang, Keith T Schmidt, Debomoy K Lahiri, Michael A Tones, Margaret M Zaleska, Barry J Hoffer, Julie A Mattison, Nigel H Greig
The endogenous incretins glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) possess neurotrophic, neuroprotective, and anti-neuroinflammatory actions. The dipeptidyl peptidase 4 (DPP-4) inhibitor sitagliptin reduces degradation of endogenous GLP-1 and GIP, and, thereby, extends the circulation of these protective peptides. The current nonhuman primate (NHP) study evaluates whether human translational sitagliptin doses can elevate systemic and central nervous system (CNS) levels of GLP-1/GIP in naive, non-lesioned NHPs, in line with our prior rodent studies that demonstrated sitagliptin efficacy in preclinical models of Parkinson's disease (PD)...
March 27, 2024: GeroScience
https://read.qxmd.com/read/38531888/background-and-clinical-significance-of-biomarker-based-patient-enrichment-in-non-small-cell-lung-cancer-drug-development
#27
JOURNAL ARTICLE
Kenji Harada, Shunsuke Ono
Pharmaceutical companies have adopted biomarker-based enrichment (personalized) strategies to improve research and development productivity. We explored the background in which personalized strategies are adopted and examined whether their adoption is linked to improved efficacy of new drugs approved for non-small cell lung cancer (NSCLC) by US Food and Drug Administration (FDA). We extracted data from the first labels of drugs approved for NSCLC between May 2003 and February 2021, and performed a qualitative comparative analysis and meta-analysis...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531765/osteoporosis-management-in-patients-with-chronic-kidney-disease-ercos-study-a-challenge-in-nephrological-care
#28
JOURNAL ARTICLE
Jordi Bover, Carlos Gómez-Alonso, Enrique Casado, Minerva Rodríguez-García, María Jesús Lloret, Cristina Castro-Alonso, Laia Gifre, Fernando Henríquez-Palop, Águeda Prior-Español, Virginia López de la Manzanara, Ana María Láiz, Àngels Martínez-Ferrer, Josep Vicens Torregrosa, Secundino Cigarrán, José Luis Górriz, Marco Montomoli, Nayara Panizo, Ester Costa, Daniel Martínez-Laguna, Mariano Rodríguez, Juan F Navarro-González
Fracture risk assessment in patients with chronic kidney disease (CKD) has been included in the CKD-MBD ("Chronic Kidney Disease-Mineral and Bone Disorders") complex in international and national nephrology guidelines, suggesting for the first time the assessment of bone mineral density (BMD) if the results can influence therapeutic decision-making. However, there is very little information on actual clinical practice in this population. The main objective of the ERCOS (ERC-Osteoporosis) study is to describe the profile of patients with CKD G3-5D with osteoporosis (OP) and/or fragility fractures treated in specialized nephrology, rheumatology and internal medicine clinics in Spain...
March 25, 2024: Nefrología
https://read.qxmd.com/read/38531628/a-rapid-improvement-event-progesterone-prescribing-in-prevention-of-miscarriage
#29
JOURNAL ARTICLE
Lucy Anne Bolger, Nicola O'Riordan, Cathy Allen
A rapid improvement event (RIE) is a standard operational excellence technique that uses team-based problem solving to improve processes. In this study, a RIE was undertaken to improve progesterone prescribing rates for those with a history of miscarriage experiencing vaginal bleeding in early pregnancy. This was on the basis of a recent change in guidelines regarding prescribing in these instances. NICE guidelines changed in November 2021 after Cochrane meta-analysis and the PRISM (Progesterone in Spontaneous Miscarriage) randomised control trial demonstrated a higher incidence of live births in those prescribed vaginal micronised progesterone for threatened miscarriage, when compared with those not prescribed it...
March 26, 2024: BMJ Open Quality
https://read.qxmd.com/read/38531228/mobilizing-data-during-a-crisis-building-rapid-evidence-pipelines-using-multi-institutional-real-world-data
#30
JOURNAL ARTICLE
Jayson S Marwaha, Maren Downing, John Halamka, Amy Abernethy, Joseph B Franklin, Brian Anderson, Isaac Kohane, Kavishwar Wagholikar, John Brownstein, Melissa Haendel, Gabriel A Brat
The COVID-19 pandemic generated tremendous interest in using real world data (RWD). Many consortia across the public and private sectors formed in 2020 with the goal of rapidly producing high-quality evidence from RWD to guide medical decision-making, public health priorities, and more. Experiences were gathered from five large consortia on rapid multi-institutional evidence generation during the COVID-19 pandemic. Insights have been compiled across five dimensions: consortium composition, governance structure and alignment of priorities, data sharing, data analysis, and evidence dissemination...
March 25, 2024: Healthcare
https://read.qxmd.com/read/38530781/landscape-of-toxin-neutralizing-therapeutics-for-snakebite-envenoming-2015-2022-setting-the-stage-for-an-r-d-agenda
#31
JOURNAL ARTICLE
Juliette Borri, José María Gutiérrez, Cecilie Knudsen, Abdulrazaq G Habib, Maya Goldstein, Andrew Tuttle
BACKGROUND: Progress in snakebite envenoming (SBE) therapeutics has suffered from a critical lack of data on the research and development (R&D) landscape. A database characterising this information would be a powerful tool for coordinating and accelerating SBE R&D. To address this need, we aimed to identify and categorise all active investigational candidates in development for SBE and all available or marketed products. METHODOLOGY/PRINCIPAL FINDINGS: In this landscape study, publicly available data and literature were reviewed to canvas the state of the SBE therapeutics market and research pipeline by identifying, characterising, and validating all investigational drug and biologic candidates with direct action on snake venom toxins, and all products available or marketed from 2015 to 2022...
March 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38530670/elastomeric-fillable-infusion-pumps-an-overview-for-clinical-practice
#32
JOURNAL ARTICLE
Andrew Barton, Ed Fisher, Martin Rees-Milton
Due to advances in elastomeric pump technology, there are now devices available that can be filled with intravenous (IV) therapy at the bed or chair side. These devices are safe, reliable and enable the patient to be mobile when having their infusion. The Surefuser™+ elastomeric infusion pump is available in multiple configurations and allows patients to remain independent and receive IV therapy infusions in their own homes. The pump can also be used in the acute healthcare setting where traditional electronic infusion pumps may not be available...
August 16, 2023: British Journal of Nursing: BJN
https://read.qxmd.com/read/38530533/an-experimental-phototherapy-device-for-studying-the-effects-of-blue-light-on-patients-with-raynaud-s-phenomenon
#33
JOURNAL ARTICLE
Brett Levac, James Kerber, Emily Wagner, Jerry A Molitor, Steven S Saliterman
Raynaud's phenomenon (RP) is a condition that causes decreased blood flow to areas perfused by small blood vessels (e.g., fingers, toes). In severe cases, ulceration, gangrene, and loss of fingers may occur. Most treatments focus on inducing vasorelaxation in affected areas by the way of pharmaceuticals. Recently, animal studies have shown that vasorelaxation can be induced by non-coherent blue light (wavelength ~ 430-460 nm) through the actions of melanopsin, a photoreceptive opsin protein encoded by the OPN4 gene...
March 26, 2024: Annals of Biomedical Engineering
https://read.qxmd.com/read/38530318/blindness-of-intentions-and-metacognitive-deficits-during-moral-judgements-in-schizophrenia
#34
JOURNAL ARTICLE
Tomasz Cyrkot, David Ramsey, Monika Wójta-Kempa, Błażej Misiak, Remigiusz Szczepanowski
BACKGROUND: Previous research has shown that moral judgments are affected by social cognitive abilities, such as theory of mind (ToM). This study examines how information about an actor's beliefs and the consequences of their actions affect the moral evaluation of the character's behavior in social events. Our research builds upon previous studies, which have shown that these factors contribute differently to moral judgments made by both adults and young children. OBJECTIVES: This study aimed to explore how participants with schizophrenia and healthy controls read stories about social situations in the context of moral judgments...
March 26, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38530047/difficulties-in-disclosing-secondary-findings-by-facilities-performing-comprehensive-germline-genetic-testing-for-rare-diseases-in-japan
#35
JOURNAL ARTICLE
Kana Hiromoto, Takahiro Yamada, Mio Tsuchiya, Hiroshi Kawame, Eiji Nanba, Yuichi Goto, Shinji Kosugi
In Japan, a limited number of laboratories perform comprehensive genetic testing for rare diseases; this study investigated the attitudes of these laboratories toward the disclosure of secondary finding (SF). Following a preliminary survey, we identified laboratories conducting comprehensive genetic testing for participation. Subsequently, an online survey involving 20 selected facilities was conducted. The response rate was 80% (16/20). Of the 14 facilities, 71.4% had SFs. While 42.9% of them had a policy to disclose SFs with clinical utility, only 14...
March 26, 2024: Congenital Anomalies
https://read.qxmd.com/read/38530033/altered-pbp4-and-gdpp-functions-synergistically-mediate-mrsa-like-high-level-broad-spectrum-%C3%AE-lactam-resistance-in-staphylococcus-aureus
#36
JOURNAL ARTICLE
Li-Yin Lai, Nidhi Satishkumar, Sasha Cardozo, Vijay Hemmadi, Leonor B Marques, Liusheng Huang, Sergio R Filipe, Mariana G Pinho, Henry F Chambers, Som S Chatterjee
UNLABELLED: Infections caused by Staphylococcus aureus are a leading cause of mortality worldwide. S. aureus infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are particularly difficult to treat due to their resistance to next-generation β-lactams (NGBs) such as methicillin, nafcillin, and oxacillin. Resistance to NGBs, which is alternatively known as broad-spectrum β-lactam resistance, is classically mediated by PBP2a, a penicillin-binding protein encoded by mecA (or mecC ) in MRSA...
March 26, 2024: MBio
https://read.qxmd.com/read/38529859/-possibilities-of-%C3%A2-therapeutic-retargeting%C3%A2-of-3-hydroxypyridine-and-succinic-acid-derivatives-due-to-their-dopaminergic-action
#37
JOURNAL ARTICLE
I A Volchegorskii, L M Rassokhina, I U Miroshnichenko
The review is devoted to a comparative analysis of the clinical efficacy of the original domestic derivatives of 3-hydroxypyridine and succinic acid (emoxipine, reamberin and mexidol) in comparison with the results of an experimental study of their dopaminergic action. The position that the dopaminomimetic activity of emoxipin, reamberin and mexidol largely determines their anti-ischemic, antihypoxic, insulin-potentiating neuroprotective, nootropic and antidepressant potential has been substantiated. A comparative analysis of the safety profile of emoxipine, reamberin and mexidol was carried out, taking into account potential and real side-effects caused by iatrogenic deviations from the eudopaminergic state...
2024: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://read.qxmd.com/read/38529626/investigating-the-acceptability-of-a-culturally-adapted-acceptance-and-commitment-therapy-group-for-uk-vietnamese-communities-a-practice-based-feasibility-study
#38
JOURNAL ARTICLE
Aradhana Perry, Chelsea Gardener, Jack Shieh, Quang Tấn Hồ, Anh Doan, Kamaldeep Bhui
Acceptance and Commitment Therapy (ACT) is an empirically supported psychotherapy that offers promise for the mental health of minoritised ethnic populations. Given the diversity of those presenting to inner-city services and barriers to accessing appropriate mental healthcare, we sought to develop a culturally syntonic ACT intervention for UK Vietnamese refugee communities in a practice-based partnership project between a National Health Service and local third-sector service in East London. The aim was to explore the feasibility, acceptability and impact of the adapted intervention to inform culturally inclusive clinical practice and future research...
March 26, 2024: Transcultural Psychiatry
https://read.qxmd.com/read/38529267/interpersonal-neural-synchrony-and-mental-disorders-unlocking-potential-pathways-for-clinical-interventions
#39
Kerstin Konrad, Christian Gerloff, Simon H Kohl, David M A Mehler, Lena Mehlem, Emily L Volbert, Maike Komorek, Alina T Henn, Maren Boecker, Eileen Weiss, Vanessa Reindl
INTRODUCTION: Interpersonal synchronization involves the alignment of behavioral, affective, physiological, and brain states during social interactions. It facilitates empathy, emotion regulation, and prosocial commitment. Mental disorders characterized by social interaction dysfunction, such as Autism Spectrum Disorder (ASD), Reactive Attachment Disorder (RAD), and Social Anxiety Disorder (SAD), often exhibit atypical synchronization with others across multiple levels. With the introduction of the "second-person" neuroscience perspective, our understanding of interpersonal neural synchronization (INS) has improved, however, so far, it has hardly impacted the development of novel therapeutic interventions...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38529263/the-efficacy-of-chaihu-guizhi-ganjiang-decoction-on-chronic-non-atrophic-gastritis-with-gallbladder-heat-and-spleen-cold-syndrome-and-its-metabolomic-analysis-an-observational-controlled-before-after-clinical-trial
#40
Tao Wen, Xuan Liu, Tao Pang, Mingming Li, Guangyang Jiao, Xiangcheng Fan, Jigui Tang, Ci'an Zhang, Zhipeng Wang, Xiaoqiang Yue, Wansheng Chen, Feng Zhang
PURPOSE: The aim of this study was to verify the effectiveness and explore the mechanism of Chaihu-Guizhi-Ganjiang decoction (CGGD) in the treatment of chronic non-atrophic gastritis (CNAG) with gallbladder heat and spleen cold syndrome (GHSC) by metabolomics based on UHPLC-Q-TOF/MS. PATIENTS AND METHODS: An observational controlled before-after study was conducted to verify the effectiveness of CGGD in the treatment of CNAG with GHSC from January to June 2023, enrolling 27 patients, who took CGGD for 28 days...
2024: Drug Design, Development and Therapy
keyword
keyword
72655
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.