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https://www.readbyqxmd.com/read/28729829/cortex-parcellation-associated-whole-white-matter-parcellation-in-individual-subjects
#1
Patrick Schiffler, Jan-Gerd Tenberge, Heinz Wiendl, Sven G Meuth
The investigation of specific white matter areas is a growing field in neurological research and is typically achieved through the use of atlases. However, the definition of anatomically based regions remains challenging for the white matter and thus hinders region-specific analysis in individual subjects. In this article, we focus on creating a whole white matter parcellation method for individual subjects where these areas can be associated to cortex regions. This is done by combining cortex parcellation and fiber tracking data...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28727124/similar-effects-of-lysine-deficiency-in-muscle-biochemical-characteristics-of-fatty-and-lean-piglets
#2
P Palma-Granados, A Haro, I Seiquer, L Lara, J F Aguilera, R Nieto
The main objective of this work was to investigate the effects of feeding Lys-deficient diets on muscle biochemical characteristics, particularly intramuscular fat concentration and fatty acid profile, in a fatty (Iberian) and a conventional pig genotype (Landrace × Large White [LDW]) maintained in identical experimental conditions. Performance and plasma metabolite changes were also monitored. Twenty-eight barrows of 10 kg initial BW, 14 of Iberian and 14 of LDW breed, were randomly assigned to each of 2 experimental diets in a 2 × 2 factorial arrangement (2 breeds × 2 diets)...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28725550/dti-measures-identify-mild-and-moderate-tbi-cases-among-patients-with-complex-health-problems-a-receiver-operating-characteristic-analysis-of-u-s-veterans
#3
Keith L Main, Salil Soman, Franco Pestilli, Ansgar Furst, Art Noda, Beatriz Hernandez, Jennifer Kong, Jauhtai Cheng, Jennifer K Fairchild, Joy Taylor, Jerome Yesavage, J Wesson Ashford, Helena Kraemer, Maheen M Adamson
Standard MRI methods are often inadequate for identifying mild traumatic brain injury (TBI). Advances in diffusion tensor imaging now provide potential biomarkers of TBI among white matter fascicles (tracts). However, it is still unclear which tracts are most pertinent to TBI diagnosis. This study ranked fiber tracts on their ability to discriminate patients with and without TBI. We acquired diffusion tensor imaging data from military veterans admitted to a polytrauma clinic (Overall n = 109; Age: M = 47...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28721443/a-diffusion-spectrum-imaging-based-tractographic-study-into-the-anatomical-subdivision-and-cortical-connectivity-of-the-ventral-external-capsule-uncinate-and-inferior-fronto-occipital-fascicles
#4
Sandip S Panesar, Fang-Cheng Yeh, Christopher P Deibert, David Fernandes-Cabral, Vijayakrishna Rowthu, Pinar Celtikci, Emrah Celtikci, William D Hula, Sudhir Pathak, Juan C Fernández-Miranda
PURPOSE: The inferior fronto-occipital fasciculus (IFOF) and uncinate fasciculus (UF) are major fronto-capsular white matter pathways. IFOF connects frontal areas of the brain to parieto-occipital areas. UF connects ventral frontal areas to anterior temporal areas. Both fascicles are thought to subserve higher language and emotion roles. Controversy pertaining to their connectivity and subdivision persists in the literature, however. METHODS: High-definition fiber tractography (HDFT) is a non-tensor tractographic method using diffusion spectrum imaging data...
July 18, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28715555/application-of-a-lifestyle-based-tool-to-estimate-premature-cardiovascular-disease-events-in-young-adults-the-coronary-artery-risk-development-in-young-adults-cardia-study
#5
Holly C Gooding, Hongyan Ning, Matthew W Gillman, Christina Shay, Norrina Allen, David C Goff, Donald Lloyd-Jones, Stephanie Chiuve
Importance: Few tools exist for assessing the risk for early atherosclerotic cardiovascular disease (ASCVD) events in young adults. Objective: To assess the performance of the Healthy Heart Score (HHS), a lifestyle-based tool that estimates ASCVD events in older adults, for ASCVD events occurring before 55 years of age. Design, Setting, and Participants: This prospective cohort study included 4893 US adults aged 18 to 30 years from the Coronary Artery Risk Development in Young Adults (CARDIA) study...
July 17, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28712990/supervoxel-based-statistical-analysis-of-diffusion-tensor-imaging-in-schizotypal-personality-disorder
#6
Teng Zhang, Lin Shi, Qing Zhang, Jianlin Wu, Jian Lv, Defeng Wang
To study white matter changes in schizotypal personality disorder (SPD), we developed a new statistical analysis method based on supervoxels for diffusion tensor imaging. Twenty patients with SPD and eighteen healthy controls were recruited from a pool of 3000 first-year university undergraduates, and underwent MRI using a 3T scanner. Diffusion tensors were first normalized into ICBM-152 space followed by a supervoxel segmentation based on graph clustering to segment white matter tensors into diffusion homogeneous supervoxels...
July 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/28709907/the-details-of-structural-disconnectivity-in-psychotic-disorder-a-family-based-study-of-non-fa-diffusion-weighted-imaging-measures
#7
Stijn Michielse, Ed Gronenschild, Patrick Domen, Jim van Os, Machteld Marcelis
BACKGROUND: Diffusion Tensor Imaging (DTI) studies in psychotic disorder have shown reduced FA, often interpreted as disturbed white matter integrity. The observed 'dysintegrity' may be of multifactorial origin, as changes in FA are thought to reflect a combination of changes in myelination, fiber organization and number of axons. Examining the structural substrate of the diffusion tensor in individuals with (risk for) psychotic disorder may provide better understanding of the underlying structural changes...
July 11, 2017: Brain Research
https://www.readbyqxmd.com/read/28708285/various-led-wavelengths-affected-myofiber-development-and-satellite-cell-proliferation-of-chick-embryos-via-the-igf-1-signaling-pathway
#8
Yao Wang, Xinjie Bai, Zixu Wang, Jing Cao, Yulan Dong, Yanjun Dong, Yaoxing Chen
An effect of monochromatic light illumination on muscle mass has been discovered in chickens; however, its effect on the development of embryonic muscle remains unclear. Our previous studies demonstrated that monochromatic green light promoted satellite cell proliferation and muscle growth in post-hatching broilers. In this study, we investigated the effects and mechanisms of monochromatic light exposure on muscle development in late-embryogenesis. Seven hundred and fifty (750) fertile broiler eggs were randomly assigned to blue (B-group), green (G-group), red (R-group), white (W-group) lights or darkness (D-group) throughout the incubation period...
July 14, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28707960/biofunctionalized-hybrid-magnetic-gold-nanoparticles-as-catalysts-for-photothermal-ablation-of-colorectal-liver-metastases
#9
Sarah B White, Dong-Hyun Kim, Yang Guo, Weiguo Li, Yihe Yang, Jeane Chen, Venkateswara R Gogineni, Andrew C Larson
Purpose To demonstrate that anti-MG1 conjugated hybrid magnetic gold nanoparticles (HNPs) act as a catalyst during photothermal ablation (PTA) of colorectal liver metastases, and thus increase ablation zones. Materials and Methods All experiments were performed with approval of the institutional animal care and use committee. Therapeutic and diagnostic multifunctional HNPs conjugated with anti-MG1 monoclonal antibodies were synthesized, and the coupling efficiency was determined. Livers of 19 Wistar rats were implanted with 5 × 10(6) rat colorectal liver metastasis cell line cells...
July 13, 2017: Radiology
https://www.readbyqxmd.com/read/28706245/connexin-50-functions-as-an-adhesive-molecule-and-promotes-lens-cell-differentiation
#10
Zhengping Hu, Wen Shi, Manuel A Riquelme, Qian Shi, Sondip Biswas, Woo-Kuen Lo, Thomas W White, Sumin Gu, Jean X Jiang
Connexins play essential roles in lens homeostasis and development. Here, we identified a new role for Cx50 that mediates cell-cell adhesion function. Cx50 enhanced the adhesive capability of AQP0. Interestingly, the expression of Cx50 alone promoted cell adhesion at a comparable level to AQP0; however, this cell adhesive function was not observed with other lens connexins, Cx43 and Cx46. Moreover, the adhesive property occurred in both homotypic with Cx50 expressed in both pairing cells and heterotypic with Cx50 in only one pairing cell, and this function appears to be unrelated to its role in forming gap junction channels...
July 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28702836/sequential-language-learning-and-language-immersion-in-bilingualism-diffusion-mri-connectometry-reveals-microstructural-evidence
#11
Farzaneh Rahmani, Soheila Sobhani, Mohammad Hadi Aarabi
Study of bilingual brain has provided evidence for probable advantageous outcomes of early second language learning and brain structural correlates to these outcomes. DMRI connectometry is a novel approach that tracts fibers based on correlation of the adjacent voxels with a variable of interest or group differences. Using the data deposited by Pliatsikas et al., we investigated through diffusion MRI connectometry and correlation analysis, the structural differences in white matter tracts of 20 healthy sequential bilingual adults who used English as a second language on a daily basis, compared to 25 age matched in fiber differentiation analyses...
July 12, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28702330/neonatal-glp1r-activation-limits-adult-adiposity-by-durably-altering-hypothalamic-architecture
#12
Andrea V Rozo, Daniella A Babu, PoMan A Suen, David N Groff, Randy J Seeley, Rebecca A Simmons, Patrick Seale, Rexford S Ahima, Doris A Stoffers
OBJECTIVE: Adult obesity risk is influenced by alterations to fetal and neonatal environments. Modifying neonatal gut or neurohormone signaling pathways can have negative metabolic consequences in adulthood. Here we characterize the effect of neonatal activation of glucagon like peptide-1 (GLP-1) receptor (GLP1R) signaling on adult adiposity and metabolism. METHODS: Wild type C57BL/6 mice were injected with 1 nmol/kg Exendin-4 (Ex-4), a GLP1R agonist, for 6 consecutive days after birth...
July 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28699660/binding-of-indocyanine-green-in-polycaprolactone-fibers-using-blend-electrospinning-for-in-vivo-laser-assisted-vascular-anastomosis
#13
Annemarie Schönfeld, Zacharia Mbäıdjol Kabra, Mihai Constantinescu, Dieter Bosshardt, Michael H Stoffel, Kirsten Peters, Martin Frenz
BACKGROUND AND OBJECTIVE: The clinical application of laser-assisted vascular anastomosis is afflicted by unreliable and low bonding strengths as well as tedious handling during microvascular surgery. The challenge to be met arises from the flow-off of the chromophore during soldering that changes the absorption and stains the surrounding tissue, leading to an uncontrollable thermal damage zone. In this study, we investigated the feasibility to produce an indocyanine green (ICG)-loaded patch by electrospinning and tested its applicability to both in vitro and in vivo microvascular laser soldering...
July 12, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28698090/the-superior-frontal-transsulcal-approach-to-the-anterior-ventricular-system-exploring-the-sulcal-and-subcortical-anatomy-using-anatomic-dissections-and-dti-tractography
#14
Christos Koutsarnakis, Faidon Liakos, Aristotelis V Kalyvas, Georgios P Skandalakis, Spyros Komaitis, Fotini Christidi, Efstratios Karavasilis, Evangellia Liouta, George Stranjalis
OBJECTIVE: To explore the superior frontal sulcus morphology, trajectory of the applied surgical corridor and white matter bundles that are traversed during the superior frontal transsulcal transventricular approach METHODS: Twenty (20) normal, adult, formalin-fixed cerebral hemispheres and two (2) cadaveric heads were included in the study. The superior frontal sulcus (SFS) topography, morphology and dimensions were recorded in all specimens. Fourteen (14) hemispheres were investigated through the fiber dissection technique while the remaining six (6) were explored using coronal cuts...
July 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28695797/effects-of-630-nm-red-and-460-nm-blue-light-emitting-diode-irradiation-on-healing-of-the-skin-wound-in-japanese-big-ear-white-rabbit
#15
Yanhong Li, Jigang Zhang, Yanfeng Xu, Yunlin Han, Binbin Jiang, Lan Huang, Hua Zhu, Yuhuan Xu, Weiling Yang, Chuan Qin
Objective To observe the effects of 630 nm red light and 460 nm blue light emitting diode irradiation on the healing of skin wounds in Japanese big-ear white rabbits. Methods The skin wound model was established with 8 Japanese big-ear white rabbits. Three parts of vulnus in each rabbit were used:two parts of vulnus were irradiated vertically by red and blue LED light,respectively(15 min/time),and the distance between lights and wounds was 15 cm;the 3(rd) part of the wound was used as a control. On the 21(st) day of the wounds exposure to light,the number of healing wounds and the percentage of healing area were recorded and the treatment effect of these two light sources was compared...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28695417/a-fiber-tractography-study-of-social-emotional-related-fiber-tracts-in-children-and-adolescents-with-autism-spectrum-disorder
#16
Yun Li, Hui Fang, Wenming Zheng, Lu Qian, Yunhua Xiao, Qiaorong Wu, Chen Chang, Chaoyong Xiao, Kangkang Chu, Xiaoyan Ke
The symptoms of autism spectrum disorder (ASD) have been hypothesized to be caused by changes in brain connectivity. From the clinical perspective, the "disconnectivity" hypothesis has been used to explain characteristic impairments in "socio-emotional" function. Therefore, in this study we compared the facial emotional recognition (FER) feature and the integrity of social-emotional-related white-matter tracts between children and adolescents with high-functioning ASD (HFA) and their typically developing (TD) counterparts...
July 10, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28693603/differential-requirement-for-satellite-cells-during-overload-induced-muscle-hypertrophy-in-growing-versus-mature-mice
#17
Kevin A Murach, Sarah H White, Yuan Wen, Angel Ho, Esther E Dupont-Versteegden, John J McCarthy, Charlotte A Peterson
BACKGROUND: Pax7+ satellite cells are required for skeletal muscle fiber growth during post-natal development in mice. Satellite cell-mediated myonuclear accretion also appears to persist into early adulthood. Given the important role of satellite cells during muscle development, we hypothesized that the necessity of satellite cells for adaptation to an imposed hypertrophic stimulus depends on maturational age. METHODS: Pax7(CreER)-R26R(DTA) mice were treated for 5 days with vehicle (satellite cell-replete, SC+) or tamoxifen (satellite cell-depleted, SC-) at 2 months (young) and 4 months (mature) of age...
July 10, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/28692678/bilateral-effects-of-unilateral-cerebellar-lesions-as-detected-by-voxel-based-morphometry-and-diffusion-imaging
#18
Giusy Olivito, Michael Dayan, Valentina Battistoni, Silvia Clausi, Mara Cercignani, Marco Molinari, Maria Leggio, Marco Bozzali
Over the last decades, the importance of cerebellar processing for cortical functions has been acknowledged and consensus was reached on the strict functional and structural cortico-cerebellar interrelations. From an anatomical point of view strictly contralateral interconnections link the cerebellum to the cerebral cortex mainly through the middle and superior cerebellar peduncle. Diffusion MRI (dMRI) based tractography has already been applied to address cortico-cerebellar-cortical loops in healthy subjects and to detect diffusivity alteration patterns in patients with neurodegenerative pathologies of the cerebellum...
2017: PloS One
https://www.readbyqxmd.com/read/28684331/fiberprint-a-subject-fingerprint-based-on-sparse-code-pooling-for-white-matter-fiber-analysis
#19
Kuldeep Kumar, Christian Desrosiers, Kaleem Siddiqi, Olivier Colliot, Matthew Toews
White matter characterization studies use the information provided by diffusion magnetic resonance imaging (dMRI) to draw cross-population inferences. However, the structure, function, and white matter geometry vary across individuals. Here, we propose a subject fingerprint, called Fiberprint, to quantify the individual uniqueness in white matter geometry using fiber trajectories. We learn a sparse coding representation for fiber trajectories by mapping them to a common space defined by a dictionary. A subject fingerprint is then generated by applying a pooling function for each bundle, thus providing a vector of bundle-wise features describing a particular subject's white matter geometry...
July 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28680884/white-matter-injury-and-recovery-after-hypertensive-intracerebral-hemorrhage
#20
REVIEW
Shilun Zuo, Pengyu Pan, Qiang Li, Yujie Chen, Hua Feng
Hypertensive intracerebral hemorrhage (ICH) could very probably trigger white matter injury in patients. Through the continuous study of white matter injury after hypertensive ICH, we achieve a more profound understanding of the pathophysiological mechanism of its occurrence and development. At the same time, we found a series of drugs and treatment methods for the white matter repair. In the current reality, the research paradigm of white matter injury after hypertensive ICH is relatively obsolete or incomplete, and there are still lots of deficiencies in the research...
2017: BioMed Research International
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