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https://www.readbyqxmd.com/read/29788371/selective-nanopore-sequencing-of-human-brca1-by-cas9-assisted-targeting-of-chromosome-segments-catch
#1
Tslil Gabrieli, Hila Sharim, Dena Fridman, Nissim Arbib, Yael Michaeli, Yuval Ebenstein
Next generation sequencing (NGS) is challenged by structural and copy number variations larger than the typical read length of several hundred bases. Third-generation sequencing platforms such as single-molecule real-time (SMRT) and nanopore sequencing provide longer reads and are able to characterize variations that are undetected in NGS data. Nevertheless, these technologies suffer from inherent low throughput which prohibits deep sequencing at reasonable cost without target enrichment. Here, we optimized Cas9-Assisted Targeting of CHromosome segments (CATCH) for nanopore sequencing of the breast cancer gene BRCA1...
May 18, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29786793/a-method-for-prostate-and-breast-cancer-cell-spheroid-cultures-using-gelatin-methacryloyl-based-hydrogels
#2
Christoph Meinert, Christina Theodoropoulos, Travis J Klein, Dietmar W Hutmacher, Daniela Loessner
Modern tissue engineering technologies have delivered tools to recreate a cell's naturally occurring niche in vitro and to investigate normal and pathological cell-cell and cell-niche interactions. Hydrogel biomaterials mimic crucial properties of native extracellular matrices, including mechanical support, cell adhesion sites and proteolytic degradability. As such, they are applied as 3D cell culture platforms to replicate tissue-like architectures observed in vivo, allowing physiologically relevant cell behaviors...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29784600/breast-reconstruction-after-mastectomy-a-survey-of-surgeons-and-patients-perceptions
#3
Ariffuddin Ishak, Maya Mazuwin Yahya, Ahmad Sukari Halim
BACKGROUND: Breast reconstruction after mastectomy is important in breast cancer care. MATERIALS AND METHODS: A cross-sectional study was designed to assess surgeons' and patients' perceptions toward breast reconstruction. Questionnaires were distributed to general and breast surgeons in East Coast Malaysian hospitals and Hospital Kuala Lumpur and to postmastectomy patients with and without breast reconstruction at the Hospital Universiti Sains Malaysia and Hospital Raja Perempuan Zainab II...
April 28, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29781364/pet-ct-analysis-of-21-patients-with-breast-cancer-physiological-distribution-of-18-f-choline-and-diagnostic-pitfalls
#4
Fathinul Fikri Ahmad Saad, Mohd Hazeman Zakaria, Bahunu Appanna
Objectives 18 F-choline is a useful tracer for detecting tumours with high lipogenesis. Knowledge of its biodistribution pattern is essential to recognise physiological variants. The aim of this study was to describe the physiologic distribution of 18 F-choline and pitfalls in patients with breast cancer. Methods Twenty-one consecutive patients with breast cancer (10 premenopausal and 11 postmenopausal women; mean age, 52.82 ± 10.71 years) underwent 18 F-choline positron emission tomography (PET)/computed tomography (CT) for staging...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29780787/non-convulsive-seizure-related-to-cremophor-el%C3%A2-free-polymeric-micelle-formulation-of-paclitaxel-a-case-report
#5
Yoon Sun Shin, Kyung Jin Min, Seung Young Choi, Nak Woo Lee
Paclitaxel is a chemotherapeutic agent that is effective against ovarian, breast, lung, and other cancers. Although peripheral neurotoxicity is among the most common side effects of paclitaxel treatment, central neurotoxicity is rarely reported. When centrally mediated side effects are observed, they are attributed to Cremophor EL™ (CrEL), a surfactant-containing vehicle used for paclitaxel administration. In the present report, we discuss the case of a 72-year-old woman with ovarian carcinoma who experienced a non-convulsive seizure following administration of a CrEL-free, polymeric micelle formulation of paclitaxel...
May 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29777406/can-bovine-leukemia-virus-be-related-to-human-breast-cancer-a-review-of-the-evidence
#6
REVIEW
Lucia Martinez Cuesta, Pamela Anahi Lendez, Maria Victoria Nieto Farias, Guillermina Laura Dolcini, Maria Carolina Ceriani
The incidence of breast cancer is continuously increasing worldwide, as influenced by many factors that act synergistically. In the last decade there was an increasing interest in the possible viral etiology of human breast cancer. Since then, many viruses have been associated with this disease (murine mammary tumor virus, MMTV; Epstein-Barr virus, EBV; and human papillomavirus, HPV). Recently, BLV has been identified in human breast cancers giving rise to the hypothesis that it could be one of the causative agents of this condition...
May 18, 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29777379/the-effects-of-a-video-based-education-in-women-with-newly-diagnosed-breast-cancer-in-singapore
#7
May Leng Tan, Kim Hua Lee, Wei Sean Yong, Cheryl Rodgers
PURPOSE: The purpose of this study was to evaluate the impact of an educational video among women who were newly diagnosed with breast cancer on knowledge, anxiety, and satisfaction with their surgical decision. METHODS: A pre-post-test design was used to evaluate knowledge, anxiety, and satisfaction levels with decision-making regarding surgery among women with breast cancer. A purposive sampling strategy was implemented to compare outcomes of newly diagnosed breast cancer women who received standard of care that included breast care nurse counseling sessions and written materials to women who received standard of care plus a supplement educational video...
May 18, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29776638/breast-carcinoma-updates-in-molecular-profiling-2018
#8
REVIEW
Sudeshna Bandyopadhyay, Martin H Bluth, Rouba Ali-Fehmi
The most significant contribution of molecular subtyping of breast carcinomas has been the identification of estrogen-positive and estrogen-negative tumor subtypes. Knowledge of genetic alterations in these tumors will help clinicians identify novel therapeutic targets. Understanding the progression pathways involved in the transition of in situ carcinoma to invasive carcinoma might lead to efficient risk stratification in these patients. The Cancer Genome Analysis Network has collected genomic and epigenomic data to provide comprehensive information regarding carcinogenesis and pathway interactions...
June 2018: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29774323/encapsulated-papillary-carcinoma-in-a-man-with-gynecomastia-ultrasonography-mammography-and-magnetic-resonance-imaging-features-with-pathologic-correlation
#9
Ravza Yılmaz, Rana Günöz Cömert, Samil Aliyev, Yücel Toktaş, Semen Önder, Selman Emirikçi, Vahit Özmen
Male breast cancer is an uncommon disease that constitutes 1% of all breast cancers and encapsulated papillary carcinoma (EPC) is a rare subtype of malignant male diseases. Gynecomastia is the most common disease of the male breast. We report a 63-year-old male patient with EPC accompanied by gynecomastia that was diagnosed and treated at our breast center. Mammography showed an oval-shaped dense mass with circumscribed margins on the ground of nodular gynecomastia. On ultrasonographic exam, we saw a well-circumscribed complex mass with a solid component which was vascular on Doppler ultrasonography...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29774312/breast-cancer-prevention-current-approaches-and-future-directions
#10
REVIEW
Edward R Sauter
The topic of breast cancer prevention is very broad. All aspects of the topic, therefore, cannot be adequately covered in a single review. The objective of this review is to discuss strategies in current use to prevent breast cancer, as well as potential approaches that could be used in the future. This review does not discuss early detection strategies for breast cancer, including breast cancer screening. The breast is the most common site among women worldwide of noncutaneous cancer. Many clinical and genetic factors have been found to increase a woman's risk of developing the disease...
April 2018: European journal of breast health
https://www.readbyqxmd.com/read/29765171/risks-and-protective-factors-for-triple-negative-breast-cancer-with-a-focus-on-micronutrients-and-infections
#11
Dagmar Horakova, Katerina Bouchalova, Karel Cwiertka, Ladislav Stepanek, Jana Vlckova, Helena Kollarova
Triple negative breast cancer (TNBC) is an aggressive form of breast cancer (BC) with a poor prognosis. Second, patients cannot benefit from targeted therapy, except for those with BRCA1/2 mutations, for whom poly (ADP-ribose) polymerase (PARP) inhibition therapy using olaparib has recently been approved. As global priorities continue to be epidemiological analysis of BC risk factors and early diagnosis, this review focuses on the risks and protective factors associated with TNBC. A PubMed keyword search for new knowledge on the risks and protective factors for TNBC was carried out...
May 15, 2018: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/29764450/evaluation-of-target-dose-inhomogeneity-in-breast-cancer-treatment-due-to-tissue-elemental-differences
#12
A Fogliata, F De Rose, A Stravato, G Reggiori, S Tomatis, M Scorsetti, L Cozzi
BACKGROUND: Monte Carlo simulations were run to estimate the dose variations generated by thedifference arising from the chemical composition of the tissues. METHODS: CT datasets of five breast cancer patients were selected. Mammary gland was delineated as clinical target volume CTV, as well as CTV_lob and CTV_fat, being the lobular and fat fractions of the entire mammary gland. Patients were planned for volumetric modulated arc therapy technique, optimized in the Varian Eclipse treatment planning system...
May 15, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29760601/tumor-cell-accelerated-senescence-is-associated-with-dna-pkcs-status-and-telomere-dysfunction-induced-by-radiation
#13
Miaomiao Zhang, Xiaopeng Guo, Yue Gao, Dong Lu, Wenjian Li
Whether telomere structure integrity is related to radiosensitivity is not well investigated thus far. In this study, we investigated the relation between telomere instability and radiation-induced accelerated senescence. Partial knockdown of DNA-dependent catalytic subunit of protein kinase (DNA-PKcs) in human breast cancer cell line MCF-7 was established by small interfering RNA. Radiosensitivity of control and DNA-PKcs knockdown MCF-7 cells was analyzed by clonogenetic assay. Cell growth was measured by real-time cell electronic sensing...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29759984/ndf-a-nucleosome-destabilizing-factor-that-facilitates-transcription-through-nucleosomes
#14
Jia Fei, Haruhiko Ishii, Marten A Hoeksema, Franz Meitinger, George A Kassavetis, Christopher K Glass, Bing Ren, James T Kadonaga
Our understanding of transcription by RNA polymerase II (Pol II) is limited by our knowledge of the factors that mediate this critically important process. Here we describe the identification of NDF, a nucleosome-destabilizing factor that facilitates Pol II transcription in chromatin. NDF has a PWWP motif, interacts with nucleosomes near the dyad, destabilizes nucleosomes in an ATP-independent manner, and facilitates transcription by Pol II through nucleosomes in a purified and defined transcription system as well as in cell nuclei...
May 14, 2018: Genes & Development
https://www.readbyqxmd.com/read/29754052/detection-of-parp-1-activity-based-on-hyperbranched-poly-adp-ribose-polymers-responsive-current-in-artificial-nanochannels
#15
Yong Liu, Jiahui Fan, Haitang Yang, Ensheng Xu, Wei Wei, Yuanjian Zhang, Songqin Liu
The cellular enzyme poly ADP (ADP: adenosine diphosphate)-ribose polymerase-1 (PARP-1) plays key roles in DNA repair. Its activity is closely related to various cancer developments. Detection of PARP-1 activity is significant, however, it is relatively difficult since it lacks superiority property that can be used to detect conveniently. PARP-1 lead to the synthesis of hyperbranched poly (ADP-ribose) polymers (PAR) using nicotinamide adenine dinucleotide (NAD+ ) as substrate during DNA damage repairing. In this paper, we found that hyper-branched PAR increased the steric hindrance and reduced the flux of probe ions effectively in anodic aluminum oxide (AAO) nanochannels...
May 4, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29752341/-ercc1-rs11615-polymorphism-increases-susceptibility-to-breast-cancer-a-meta-analysis-of-4547-individuals
#16
Bingjie Li, Xiaoqing Shi, Yingying Yuan, Mengle Peng, Huifang Jin, Dongchun Qin
Excision repair cross-complementation group 1 (ERCC1), a DNA repair protein, is vital for maintaining genomic fidelity and integrity. Despite the fact that a mounting body of case-control studies has concentrated on investigating the association of the ERCC1 rs11615 polymorphism and breast cancer risk, there is still no consensus on it. We conducted the current meta-analysis of all eligible articles to reach a much more explicit conclusion on this ambiguous association. A total of seven studies involving 2354 breast cancer cases and 2193 controls were elaborately selected for this analysis from the Embase, EBSCO, Pubmed, WanFang and China National Knowledge Infrastructure (CNKI) databases...
May 11, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29751106/curcumin-exerts-its-antitumor-effects-in-a-context-dependent-fashion
#17
Dominique Kreutz, Chomdao Sinthuvanich, Andrea Bileck, Lukas Janker, Besnik Muqaku, Astrid Slany, Christopher Gerner
Proteome profiling profoundly contributes to the understanding of cell response mechanisms to drug actions. Such knowledge may become a key to improve personalized medicine. In the present study, the effects of the natural remedy curcumin on breast cancer model systems were investigated. MCF-7, ZR-75-1 and TGF-β1 pretreated fibroblasts, mimicking cancer-associated fibroblasts (CAFs), were treated independently as well as in tumor cell/CAF co-cultures. Remarkably, co-culturing with CAF-like cells (CLCs) induced different proteome alterations in MCF-7 and ZR-75-1 cells, respectively...
May 8, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29743947/nursing-intervention-in-women-who-developed-lymphedema-after-undergoing-a-modified-radical-mastectomy-a-pre-experimental-study
#18
Gloria Daniela de la Borbolla Martínez, Martha Elena Huitzache Martínez, Nicolás Padilla Raygoza
The aim of this study was to analyse the effect of a nursing intervention in increasing the therapeutic self-care demand in patients with breast cancer-related lymphedema after a mastectomy. The pre-experiment was carried out on women in the State Cancer Institute in Colima, Mexico. Thirty women who had undergone a mastectomy were included in this study. Each woman received a nursing intervention to increase her knowledge, skills and motivation, which are the components of therapeutic self-care demand. Students' t and P values were calculated for paired means, and the McNemar X2 test was performed for paired categorical variables...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29742288/metastatic-breast-cancer-to-the-liver-with-hepatoid-features-and-hep-par-1-antibody-positive-mimicking-hepatocellular-carcinoma
#19
Authur Affleck, William B Lyman, W Carl Jacobs, Chad A Livasy, John B Martinie, David A Iannitti, Dionisios Vrochides
The hepatocyte paraffin 1 antibody (Hep Par 1) has a high positive predictive value for differentiating hepatocellular carcinoma from cholangiocarcinoma and metastatic carcinoma.1 We report a case of metastatic breast cancer to the liver with hepatoid histology and strong positive staining for Hep Par 1 mimicking hepatocellular carcinoma. To our knowledge, primary breast carcinoma staining Hep Par 1 positive has not been reported in the setting of hepatic metastasis. This article is protected by copyright. All rights reserved...
May 9, 2018: Histopathology
https://www.readbyqxmd.com/read/29741646/breast-cancer-screening-behavior-attitude-barriers-among-middle-aged-chinese-women-in-macao-china
#20
Yan Xiang Gan, Cheng-Kin Lao, Alexandre Chan
Background: Breast cancer is the third leading cause of death from cancer among females in Macao, but little is known about local practice of breast cancer screening. The study aims to evaluate breast cancer screening behaviors and to identify the predictors of insufficient knowledge and attitudes towards breast cancer and its screening among female residents. Methods: This was a cross-sectional study conducted from April to June 2016 in Macao. Quota sampling of women completed the modified Chinese Breast Cancer Screening Beliefs questionnaire (CBCSB) to assess their breast cancer-related perceptions, screening attitudes and behaviors...
May 8, 2018: Journal of Public Health
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