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https://www.readbyqxmd.com/read/28635972/experiences-and-concerns-of-lesbian-gay-or-bisexual-survivors-of-colorectal-cancer
#1
Allyson Baughman, Melissa A Clark, Ulrike Boehmer
PURPOSE/OBJECTIVES: To identify the experiences and needs of lesbian, gay, or bisexual (LGB) survivors of colorectal cancer (CRC) and to expand the current understanding of LGB survivorship by obtaining in-depth knowledge of survivorship among individuals with a cancer other than breast or prostate. 
. RESEARCH APPROACH: Qualitative, semistructured individual interviews via telephone.
. SETTING: Participants were recruited using social media, flyers, word of mouth, and contact with LGB and cancer organizations during a four-month period...
May 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28629329/personalised-informed-choice-on-evidence-and-controversy-on-mammography-screening-study-protocol-for-a-randomized-controlled-trial
#2
Anna Roberto, Cinzia Colombo, Giulia Candiani, Livia Giordano, Paola Mantellini, Eugenio Paci, Roberto Satolli, Mario Valenza, Paola Mosconi
BACKGROUND: In Italy women aged 50-69 are invited for a population-based breast cancer (BC) screening. Physicians, policy makers and patients associations agree on the need to inform women about the benefits and harms in order to permit an informed decision. Decision aids (DA) are an effective way to support people in their decisions about health. This trial aims to assess women's informed choices, according to their health literacy and values, on participating or not in BC screening for the first time...
June 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28627585/role-of-metadherin-in-estrogen-regulated-gene-expression
#3
Yujun Li, Jesus Gonzalez Bosquet, Shujie Yang, Kristina W Thiel, Yuping Zhang, Haitao Liu, Kimberly K Leslie, Xiangbing Meng
The disruption of estrogen signaling is widely associated with the development of breast, endometrial and ovarian cancers. As a multifunctional mediator of carcinogenesis, metadherin (MTDH)/astrocyte elevated gene-1 (AEG-1) overexpression has been associated with numerous types of cancer, with reported roles in tumor initiation, proliferation, invasion, metastasis and chemoresistance. At the molecular level, MTDH has been shown to interact with proteins that drive tumorigenesis, including nuclear factor-κB (NF-κB), promyelocytic leukaemia zinc finger (PLZF), BRCA2- and CDKN1A (p21Cip1/Waf-1/mda-6)-interacting protein α (BCCIPα) and staphylococcal nuclease and tudor domain containing 1 (SND1)...
June 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28624990/nutrition-literacy-among-cancer-survivors-feasibility-results-from-the-healthy-eating-and-living-against-breast-cancer-heal-bca-study-a-pilot-randomized-controlled-trial
#4
Niyati Parekh, Jieying Jiang, Marissa Buchan, Marleen Meyers, Heather Gibbs, Paul Krebs
Knowledge of nutrition among breast cancer patients is insufficient, despite their motivation to seek valid information about healthy food choices. This study examines the feasibility of nutrition education workshops for cancer survivors, to inform the design of a multi-center intervention. Fifty-nine female English-speaking breast cancer patients, who had completed treatment, were enrolled. Participants were randomized to the intervention or control group. The intervention group attended six nutrition education sessions, and the control group received brochures...
June 17, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28621548/an-investigation-into-the-mammographic-appearances-of-missed-breast-cancers-when-recall-rates-are-reduced
#5
Norhashimah Mohd Norsuddin, Claudia Mello-Thoms, Warren Reed, Mary Rickard, Sarah Lewis
OBJECTIVES: This study investigated whether certain mammographic appearances of breast cancer are missed when radiologists read at lower recall rates. METHODS: Five radiologists read one identical test set of 200 mammographic (180 normal cases and 20 abnormal cases) three times and were requested to adhere to three different recall rate conditions: free recall, 15% and 10%. The radiologists were asked to mark the locations of suspicious lesions and provide a confidence rating for each decision...
June 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28618963/noxin-promotes-proliferation-of-breast-cancer-cells-via-p38-atf2-signaling-pathway
#6
Xiupeng Zhang, Yong Zhang, Chuifeng Fan, Liang Wang, Yang Liu, Ailin Li, Guiyang Jiang, Haijing Zhou, Lin Cai, Yuan Miao
Noxin (also called chromosome 11 open reading frame 82 or DNA damage-induced apoptosis suppressor) is associated with anti-apoptosis and cell proliferation in response to stress signals. However, to our knowledge, the role of Noxin in regulating cell proliferation is still controversial and there are no reports of the function and clinicopathological association in breast cancer. In this study, immunohistochemistry results showed that Noxin expression was significantly correlated with advanced tumor-node-metastasis stage ( p = 0...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28615672/reconstruction-of-pathway-modification-induced-by-nicotinamide-using-multi-omic-network-analyses-in-triple-negative-breast-cancer
#7
Ji Young Kim, Hyebin Lee, Jongmin Woo, Wang Yue, Kwangsoo Kim, Seongmin Choi, Ja-June Jang, Youngsoo Kim, In Ae Park, Dohyun Han, Han Suk Ryu
Triple negative breast cancer (TNBC) is characterized by an aggressive biological behavior in the absence of a specific target agent. Nicotinamide has recently been proven to be a novel therapeutic agent for skin tumors in an ONTRAC trial. We performed combinatory transcriptomic and in-depth proteomic analyses to characterize the network of molecular interactions in TNBC cells treated with nicotinamide. The multi-omic profiles revealed that nicotinamide drives significant functional alterations related to major cellular pathways, including the cell cycle, DNA replication, apoptosis and DNA damage repair...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28613915/inter-country-analysis-of-breast-density-classification-using-visual-grading
#8
Christine N Damases, Peter Hogg, Mark F McEntee
OBJECTIVE: Disagreement in mammographic breast density (MBD) assessment can impact breast cancer risk stratification, choices of further breast cancer screening intervals and pathways. This study examines whether inter-country MBD expectations and assessment approaches are associated with differences in MBD assessment. METHODS: Twenty American Board of Radiology (ABR) examiners and 24 United Kingdom (UK) practitioners using the 4(th) edition BI-RADS(®) lexicon assessed 40 mammogram cases of 20 women...
June 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28612125/impact-of-bilateral-prophylactic-mastectomy-and-immediate-reconstruction-on-health-related-quality-of-life-in-women-at-high-risk-for-breast-carcinoma-results-of-the-mastectomy-reconstruction-outcomes-consortium-study
#9
Colleen M McCarthy, Jennifer B Hamill, Hyungjin Myra Kim, Ji Qi, Edwin Wilkins, Andrea L Pusic
BACKGROUND: Although bilateral prophylactic mastectomy (BPM) can reduce the risk of breast cancer, the decision to proceed surgically can have significant consequences and requires careful deliberation. To facilitate decision making for women at high risk for breast carcinoma, the risks and benefits of BPM should be well-elucidated. We sought to determine the effects of BPM and immediate reconstruction on health-related quality-of-life outcomes among a multisite cohort of women at high risk for breast carcinoma...
June 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28611039/chemoprevention-uptake-among-women-with-atypical-hyperplasia-and-lobular-and-ductal-carcinoma-in-situ
#10
Meghna S Trivedi, Austin M Coe, Alejandro Vanegas, Rita Kukafka, Katherine Crew
Women with atypical hyperplasia (AH) and lobular or ductal carcinoma in situ (LCIS/DCIS) are at increased risk of developing invasive breast cancer. Chemoprevention with selective estrogen receptor modulators or aromatase inhibitors can reduce breast cancer risk; however, uptake is estimated to be less than 15% in these populations. We sought to determine which factors are associated with chemoprevention uptake in a population of women with AH, LCIS, and DCIS. Women diagnosed with AH/LCIS/DCIS between 2007 and 2015 without a history of invasive breast cancer were identified (n=1719)...
June 13, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28610679/the-presence-of-a-membrane-bound-progesterone-receptor-induces-growth-of-breast-cancer-with-norethisterone-but-not-with-progesterone-a-xenograft-model
#11
Yue Zhao, Xiangyan Ruan, Husheng Wang, Xue Li, Muqing Gu, Lijuan Wang, Yanglu Li, Harald Seeger, Alfred O Mueck
OBJECTIVES: During menopausal hormone therapy (MHT) a possible increase in breast cancer risk is thought to depend mainly on the progestogen component. In vitro studies have shown that the progesterone receptor membrane component 1 (PGRMC1) is important for tumor proliferation induced by progestogens. The primary aim of this study was to compare for the first time the natural progestogen, progesterone (P), with a synthetic progestogen, norethisterone (NET), using a xenograft model. METHODS: MCF7 cells, transfected with PGRMC1 plasmid or empty vector, were injected into nude mice and estradiol (E2) pellets were implanted...
August 2017: Maturitas
https://www.readbyqxmd.com/read/28610411/modified-bat-algorithm-for-feature-selection-with-the-wisconsin-diagnosis-breast-cancer-wdbc-dataset
#12
Suganthi Jeyasingh, Malathi Veluchamy
Early diagnosis of breast cancer is essential to save lives of patients. Usually, medical datasets include a large variety of data that can lead to confusion during diagnosis. The Knowledge Discovery on Database (KDD) process helps to improve efficiency. It requires elimination of inappropriate and repeated data from the dataset before final diagnosis. This can be done using any of the feature selection algorithms available in data mining. Feature selection is considered as a vital step to increase the classification accuracy...
May 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28609273/knowledge-regarding-fertility-preservation-in-cancer-patients-a-population-based-survey-among-brazilian-people-during-the-pink-october-awareness-event
#13
Mauricio B Chehin, Tatiana Cs Bonetti, Paulo C Serafini, Eduardo LA Motta
OBJECTIVE: The aim of this study was to assess the knowledge about the risk of infertility in cancer patients after treatment, and the options for fertility preservation based on a survey carried out during the 2013 Pink October campaign. METHODS: This survey was carried out during the 2013 Pink October event in the most important public park of São Paulo, Brazil. Approximately 900 people expressed interest in learning about breast cancer prevention and fertility preservation by participating in workshops, and 242 people filled out a questionnaire...
June 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28605117/patient-perspectives-on-nurse-practitioner-care-in-oncology-in-canada
#14
Sarah Stahlke, Krista Rawson, Edith Pituskin
PURPOSE: The purpose of this study was to add to what is known about patient satisfaction with nurse practitioner (NP) care, from the perspective of breast cancer patients who were followed by an NP. METHODS AND DESIGN: This study utilized Interpretive Description, a qualitative method aimed at making sense of the experiential aspects of health care and developing practical knowledge for improved care. Nine patients receiving NP-led care in an outpatient breast cancer clinic were interviewed about their perspectives on and experiences with NP-led care...
June 12, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28605115/interventions-promoting-breast-cancer-screening-among-turkish-women-with-global-implications-a-systematic-review
#15
Selda Secginli, Nursen O Nahcivan, Gussun Gunes, Ritin Fernandez
BACKGROUND: Breast cancer is a major health concern and remains the most common malignancy in women worldwide and in Turkey. Mammography, clinical breast examination (CBE), and breast self-examination (BSE) are recommended methods to detect early breast cancer in women. Many strategies have been developed to increase the rates of mammography, CBE, and BSE among Turkish women. Despite the benefits of breast cancer screening, these modalities are still underutilized by the majority of Turkish women...
June 12, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28603633/in-vitro-metabolism-of-exemestane-by-hepatic-cytochrome-p450s-impact-of-nonsynonymous-polymorphisms-on-formation-of-the-active-metabolite-17%C3%AE-dihydroexemestane
#16
Amity Peterson, Zuping Xia, Gang Chen, Philip Lazarus
Exemestane (EXE) is an endocrine therapy commonly used by postmenopausal women with hormone-responsive breast cancer due to its potency in inhibiting aromatase-catalyzed estrogen synthesis. Preliminary in vitro studies sought to identify phase I EXE metabolites and hepatic cytochrome P450s (CYP450s) that participate in EXE biotransformation. Phase I metabolites were identified by incubating EXE with HEK293-overexpressed CYP450s. CYP450s 1A2, 2C8, 2C9, 2C19, 2D6, 3A4, and 3A5 produce 17β-dihydroexemestane (17β-DHE), an active major metabolite, as well as two inactive metabolites...
June 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28602450/pain-sensory-disturbances-and-psychological-distress-among-danish-women-treated-for-ductal-carcinoma-in-situ-an-exploratory-study
#17
Birgitte Goldschmidt Mertz, Helle M Duriaud, Niels Kroman, Kenneth G Andersen
Ductal carcinoma in situ is a noninvasive precancer condition. The treatment resembles the treatment of invasive breast cancer. The aim of this exploratory study was to gain knowledge on the level of postoperative pain, sensory disturbances, and distress among a small group of Danish women with ductal carcinoma in situ who had sentinel lymph node biopsy in order to plan a population study. A subgroup of patients with ductal carcinoma in situ (n = 20) was compared to patients with invasive breast cancer (n = 455) at time of diagnosis and after 12 months...
June 8, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/28601027/a-semantic-interoperability-approach-to-support-integration-of-gene-expression-and-clinical-data-in-breast-cancer
#18
Raul Alonso-Calvo, Sergio Paraiso-Medina, David Perez-Rey, Enrique Alonso-Oset, Ruud van Stiphout, Sheng Yu, Marian Taylor, Francesca Buffa, Carlos Fernandez-Lozano, Alejandro Pazos, Victor Maojo
INTRODUCTION: The introduction of omics data and advances in technologies involved in clinical treatment has led to a broad range of approaches to represent clinical information. Within this context, patient stratification across health institutions due to omic profiling presents a complex scenario to carry out multi-center clinical trials. METHODS: This paper presents a standards-based approach to ensure semantic integration required to facilitate the analysis of clinico-genomic clinical trials...
June 5, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28600666/papillary-thyroid-carcinoma-metastasizing-to-anaplastic-meningioma-an-unusual-case-of-tumor-to-tumor-metastasis
#19
Sumit Das, Navjot Chaudhary, Lee-Cyn Ang, Joseph S Megyesi
Tumor-to-tumor metastasis is a relatively uncommon entity, whereby the so-called 'recipient' tumor is involved by another biologically unrelated 'donor' tumor. Intracranially, meningioma (WHO grade 1) is the most common recipient tumor, while breast and lung cancers are the most common donor tumors. We present an unusual case of intracranial tumor-to-tumor metastasis involving papillary thyroid carcinoma (PTC) believed to have metastasized to an anaplastic meningioma (WHO grade 3). The patient is a 64-year-old female with a history of PTC, whose neuroimaging, performed as part of her staging workup, revealed a right parietal scalp lesion...
June 9, 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28599484/anticancer-effect-of-curcumin-inhibits-cell-growth-through-mir-21-pten-akt-pathway-in-breast-cancer-cell
#20
Xinzheng Wang, Yakai Hang, Jinbiao Liu, Yongqiang Hou, Ning Wang, Mingjun Wang
Curcumin is a polyphenol extracted from turmeric, which that belongs to the Zingiberaceae family. Curcumin has numerous effects, including anti-inflammatory, antitumor, anti-oxidative and antimicrobial effects. However, the effects of curcumin on human breast cancer cells remain largely unknown. The aim of the present study was to investigate the anticancer effects and the mechanisms by which curcumin affects breast cancer cells. The anticancer effect of curcumin on cell viability and cytotoxicity on human breast cancer MCF-7 cells was analyzed using 3-(4,5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide and lactate dehydrogenase assays, respectively...
June 2017: Oncology Letters
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