Michele Joana Alves, Brigitte M Browe, Ana Carolina Rodrigues Dias, Juliet Torres, Giuliana Zaza, Suzy Bangudi, Jessica Blackburn, Wesley Wang, Silvio de Araujo Fernandes-Junior, Paollo Fadda, Amanda Toland, Lisa A Baer, Kristin I Stanford, Catherine Czeisler, Alfredo J Garcia, José Javier Otero
Neonatal sepsis remains one of the leading causes of mortality in newborns. Several brainstem-regulated physiological processes undergo disruption during neonatal sepsis. Mechanistic knowledge gaps exist at the interplay between metabolism and immune activation to brainstem neural circuits and pertinent physiological functions in neonates. To delineate this association, we induced systemic inflammation either by TLR4 (LPS) or TLR1/2 (PAM3CKS4) ligand administration in postnatal day 5 mice (PD5). Our findings show that LPS and PAM3CSK4 evoke substantial changes in respiration and metabolism...
March 30, 2024: Brain, Behavior, and Immunity