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Harrigan dissection

Christoph J Griessenauer, Paul M Foreman, John P Deveikis, Mark R Harrigan
The pathophysiology of extracranial traumatic aneurysm formation has not been fully elucidated. Intraarterial optical coherence tomography (OCT), an imaging modality capable of micrometer cross-sectional resolution, was used to evaluate patients presenting with saccular traumatic aneurysms of the internal carotid artery (ICA). Two consecutive trauma patients diagnosed with saccular traumatic aneurysms of the cervical ICA, per the institutional screening protocol for traumatic cerebrovascular injury, underwent digital subtraction angiography (DSA) with OCT...
February 2016: Journal of Neurosurgery
Paul M Foreman, Christoph J Griessenauer, Michelle Chua, Mark N Hadley, Mark R Harrigan
OBJECT Approximately 10% of patients with blunt traumatic extracranial cerebrovascular injury have a complete occlusion of the vertebral artery (VA). Ischemic stroke due to embolization of thrombus from an occluded VA following cervical spine surgery has been observed. The risk of ischemic stroke with cervical spine surgery in the presence of an occluded VA, however, has never been determined. METHODS A retrospective chart review of 52 patients with a VA occlusion following a blunt trauma was performed. Clinical and radiographic characteristics were collected and analyzed...
July 17, 2015: Journal of Neurosurgery. Spine
Matthew S Dahabieh, Marcel Ooms, Chanson Brumme, Jeremy Taylor, P Richard Harrigan, Viviana Simon, Ivan Sadowski
BACKGROUND: Molecular latency allows HIV-1 to persist in resting memory CD4+ T-cells as transcriptionally silent provirus integrated into host chromosomal DNA. Multiple transcriptional regulatory mechanisms for HIV-1 latency have been described in the context of progressive epigenetic silencing and maintenance. However, our understanding of the determinants critical for the establishment of latency in newly infected cells is limited. RESULTS: In this study, we used a recently described, doubly fluorescent HIV-1 latency model to dissect the role of proviral integration sites and cellular activation state on direct non-productive infections at the single cell level...
2014: Retrovirology
Mark R Harrigan, Jordan A Weinberg, Ya-Sin Peaks, Steven M Taylor, Luis P Cava, Joshua Richman, Beverly C Walters
BACKGROUND: Extracranial traumatic cerebrovascular injury (TCVI) is present in 1-3% of all blunt force trauma patients. Although options for the management of patients with these lesions include anticoagulation, antiplatelet agents, and endovascular treatment, the optimal management strategy for patients with these lesions is not yet established. OBJECTIVE: Multidisciplinary survey of clinicians about current management of TCVI. METHODS: A six-item multiple-choice survey was sent by electronic mail to a total of 11,784 neurosurgeons, trauma surgeons, stroke neurologists, and interventional radiologists...
2011: World Journal of Emergency Surgery: WJES
Martin M Mortazavi, Ketan Verma, R Shane Tubbs, Mark Harrigan
Traumatic cerebral dissections are rare but potentially dangerous conditions that through improved diagnostics have recently gained increased interest. However, there is still a significant lack of knowledge on the natural history, as well as on the best treatment options. Most of the literature on this topic consists of case reports and retrospective studies with no prospective randomized controlled studies. In our review, we highlight the fact that there is no level 1 evidence for the natural history of cerebral dissections or for the best treatment...
December 2011: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Matthew R Fusco, Mark R Harrigan
Spontaneous cerebrovascular dissections are subintimal or subadventitial cervical carotid and vertebral artery wall injuries and are the cause of as many as 2% of all ischemic strokes. Spontaneous dissections are the leading cause of stroke in patients younger than 45 years of age, accounting for almost one fourth of strokes in this population. A history of some degree of trivial trauma is present in nearly one fourth of cases. Subsequent mortality or neurological morbidity is usually the result of distal ischemia produced by emboli released from the injury site, although local mass effect produced by arterial dilation or aneurysm formation also can occur...
January 2011: Neurosurgery
Matthew R Fusco, Mark R Harrigan
Traumatic cerebrovascular injury (TCVI) is present in approximately 1% of all blunt force trauma patients and is associated with injuries such as head and cervical spine injuries and thoracic trauma. Increased recognition of patients with TCVI in the past quarter century has been because of aggressive screening protocols and noninvasive imaging with computed tomography angiography. Extracranial carotid and vertebral artery injuries demonstrate a spectrum of severity, from intimal disruption to traumatic aneurysm formation or vessel occlusion...
February 2011: Neurosurgery
Kevin Y Njabo, Anthony J Cornel, Ravinder N M Sehgal, Claire Loiseau, Wolfgang Buermann, Ryan J Harrigan, John Pollinger, Gediminas Valkiūnas, Thomas B Smith
BACKGROUND: The mosquito vectors of Plasmodium spp. have largely been overlooked in studies of ecology and evolution of avian malaria and other vertebrates in wildlife. METHODS: Plasmodium DNA from wild-caught Coquillettidia spp. collected from lowland forests in Cameroon was isolated and sequenced using nested PCR. Female Coquillettidia aurites were also dissected and salivary glands were isolated and microscopically examined for the presence of sporozoites. RESULTS: In total, 33% (85/256) of mosquito pools tested positive for avian Plasmodium spp...
August 10, 2009: Malaria Journal
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