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https://www.readbyqxmd.com/read/28220823/treatment-of-stress-urinary-incontinence-in-men-with-spinal-cord-injury-minimally-invasive-minimally-effective
#1
J Pannek, J Wöllner
STUDY DESIGN: Retrospective chart review. OBJECTIVES: To assess the outcome of minimally invasive treatment of stress urinary incontinence with alloplastic slings in patients with neurogenic lower urinary tract dysfunction. SETTING: Switzerland. METHODS: The patient database of a tertiary urologic referral center was screened for male patients with SCI who underwent implantation of a suburethral sling between June 2009 and December 2015...
February 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28220079/muro-neuro-urodynamics-a-review-of-the-functional-assessment-of-mouse-lower-urinary-tract-function
#2
REVIEW
Hiroki Ito, Anthony E Pickering, Yasuhiko Igawa, Anthony J Kanai, Christopher H Fry, Marcus J Drake
Background: Mouse urodynamic tests are fundamental to understanding normal lower urinary tract (LUT) function. These experiments also contribute to our understanding of neurological dysfunction, pathophysiological processes, and potential mechanisms of therapy. Objectives: Systematic assessment of published evidence on urodynamics, advantages and limitations of different urodynamic measurements in mice, and consideration of potential implications for the clinical field. Methods: A search using specific search-terms for urodynamic studies and mice was conducted on PubMed (from inception to 1 July 2016)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28216929/outcomes-of-transurethral-resection-and-holmium-laser-enucleation-in-more-than-60-g-of-prostate-a-prospective-randomized-study
#3
Ankur Jhanwar, Rahul J Sinha, Ankur Bansal, Gaurav Prakash, Kawaljit Singh, Vishwajeet Singh
AIM: Transurethral resection of prostate (TURP) is considered a gold standard surgical procedure. The management of benign prostatic hyperplasia (BPH) has undergone tremendous change in recent years and shifted from open to minimal invasive procedure. With the advancement in technology and skills of surgeons, lasers have been used more liberally, particularly holmium laser. Holmium laser enucleation of prostate (HoLEP) is seen as close rival of TURP. The objective if this study is to observe long- and short-term outcomes of transurethral resection and holmium laser enucleation in the prostate of more than 60 g...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28215681/sperm-evaluation-of-jungle-cat-felis-chaus-obtained-by-urethral-catheterization-ct-after-medetomidine-administration
#4
M S Kheirkhah, M Mollapour Sisakht, M Mohammadsadegh, H R Moslemi
This study aimed to evaluate semen from Jungle Cat (Felis chaus) by urethral catheterization (CT) after medetomidine administration that offers feasible and different approaches to obtaining good quality sperm, especially in wild felids. Accordingly, this method was tested in five Jungle Cats. After general anesthesia with the α2-agonist medetomidine (which also stimulates semen release into the urethra) and ketamine, an abdomen ultrasound was performed to locate dilation of the first segment of the urethra (prostatic urethra)...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28214570/routine-urethrograpy-after-buccal-graft-bulbar-urethroplasty-the-impact-of-initial-urethral-leak-on-surgical-success
#5
Erik T Grossgold, Jairam R Eswara, Cary L Siegel, Joel Vetter, Steven B Brandes
OBJECTIVE: To determine the long-term impact of extravasation at initial post-urethroplasty urethrogram, we present a novel classification system and report the association of leak severity with outcome. MATERIALS AND METHODS: 91 patients underwent buccal graft urethroplasties of the bulbar urethra from 2007-2015. Median time to urethrogram was 23d. All leaks were characterized by length and width. Cutoffs for length and width were calculated using ROC curves. Each urethrogram was graded 0-3 (0=no leak) with one point given for any leak, length ≥1...
February 15, 2017: Urology
https://www.readbyqxmd.com/read/28210823/non-ablative-erbium-yag-laser-for-the-treatment-of-type-iii-stress-urinary-incontinence-intrinsic-sphincter-deficiency
#6
Adrian Gaspar, Hugo Brandi
The objective of this pilot study was to determine the safety and efficacy of a new non-ablative erbium YAG laser procedure for the treatment of type III stress urinary incontinence (intrinsic sphincter deficiency) in women. Twenty-two patients with a Valsalva leak point pressure less than 60 cm H2O were recruited and treated with a non-ablative erbium laser delivering low fluence pulses inside the whole length of the urethra through a specially designed cannula. Treatment consisted of two treatment sessions with a 3-week interval in-between...
February 16, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28207890/mucosal-stromal-fibroblasts-markedly-enhance-hiv-infection-of-cd4-t-cells
#7
Jason A Neidleman, Joseph C Chen, Nargis Kohgadai, Janis A Müller, Anders Laustsen, Karthiga Thavachelvam, Karen S Jang, Christina M Stürzel, Jennifer J Jones, Christina Ochsenbauer, Avantika Chitre, Ma Somsouk, Maurice M Garcia, James F Smith, Ruth M Greenblatt, Jan Münch, Martin R Jakobsen, Linda C Giudice, Warner C Greene, Nadia R Roan
Understanding early events of HIV transmission within mucosal tissues is vital for developing effective prevention strategies. Here, we report that primary stromal fibroblasts isolated from endometrium, cervix, foreskin, male urethra, and intestines significantly increase HIV infection of CD4+ T cells-by up to 37-fold for R5-tropic HIV and 100-fold for X4-tropic HIV-without themselves becoming infected. Fibroblasts were more efficient than dendritic cells at trans-infection and mediate this response in the absence of the DC-SIGN and Siglec-1 receptors...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28207316/calcium-sulfate-dihydrate-urolithiasis-in-a-pet-rabbit
#8
Jaroslav Kucera, Tamara Koristkova, Barbora Gottwaldova, Vladimir Jekl
CASE DESCRIPTION A 3-year-old sexually intact male rabbit (Oryctolagus cuniculus) was evaluated because of a 1-day history of signs of anorexia and depression. CLINICAL FINDINGS Clinical examination revealed signs of depression, hunched posture, low skin elasticity (suggesting dehydration), slightly distended abdomen, and penile and preputial edema. The owner reported that the rabbit had been fed a routine diet, received water via a sipper bottle, and was allowed free movement around the home. It had been observed by the owner to bite and chew gypsum-based plaster from the walls of the home...
March 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28192614/cone-beam-ct-based-adaptive-planning-improves-permanent-prostate-brachytherapy-dosimetry-an-analysis-of-1266-patients
#9
Hendrik Westendorp, Carel J Hoekstra, Jos J Immerzeel, Sandrine M G van de Pol, Charles G H J Niël, Robert A J Kattevilder, Tonnis T Nuver, André W Minken, Marinus A Moerland
PURPOSE: To evaluate adaptive planning for permanent prostate brachytherapy and to identify the prostate regions that needed adaptation. METHODS AND MATERIALS: After the implantation of stranded seeds, using real-time intraoperative planning, a transrectal ultrasound (TRUS)-scan was obtained and contoured. The positions of seeds were determined on a C-arm cone-beam Computed Tomography (CBCT)-scan. The CBCT-scan was registered to the TRUS-scan using fiducial gold markers...
February 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28191788/full-thickness-skin-mesh-graft-vaginoplasty-a-skin-sparing-technique
#10
Guilherme Lang Motta, Patric Machado Tavares, Gabriel Veber Moisés Silva, Milton Berger, Brasil Silva Neto, Tiago Elias Rosito
INTRODUCTION: The ideal vaginoplasty method should promote good cosmetic and functional results with low morbidity. We describe a new technique for congenital vaginal agenesis using a full-thickness perforated skin graft. MATERIALS AND METHODS: We report an 18 year old patient with vaginal agenesis (Morris syndrome) that undergone a modified version of McIndoe vaginoplasty. Patient is set in a low lithotomy position and lateral traction sutures are placed in labia and a 16Fr urethral catheter inserted...
January 27, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28190638/long-term-toxicity-and-health-related-quality-of-life-after-single-fraction-high-dose-rate-brachytherapy-boost-and-hypofractionated-external-beam-radiotherapy-for-intermediate-risk-prostate-cancer
#11
N Shahid, A Loblaw, H T Chung, P Cheung, E Szumacher, C Danjoux, R Sankreacha, L Zhang, A Deabreu, A Mamedov, G Morton
AIMS: To report health-related quality of life (HRQOL) and toxicity in prostate cancer patients treated with single-fraction high dose rate (HDR) brachytherapy boost and external beam radiotherapy (EBRT). MATERIALS AND METHODS: Patients with intermediate-risk prostate cancer were accrued to a phase II clinical trial of 15 Gy HDR boost and EBRT to a dose of 37.5 Gy in 15 fractions. HRQOL (Expanded Prostate Cancer Index Composite [EPIC]), urinary symptoms (International Prostate Symptom Score [IPSS]), erectile function (International Index of Erectile Function [IIEF]) and toxicity (Common Terminology Criteria for Adverse Events [CTCAE], version 3...
February 9, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28185316/applying-translabial-ultrasound-to-detect-synthetic-slings-you-can-do-it-too-a-comparison-of-urology-trainees-to-an-attending-radiologist
#12
Jim K Shen, Daniel Faaborg, Glenn Rouse, Isaac Kelly, Roger Li, Muhannad Alsyouf, Kristene Myklak, Brian Distelberg, Andrea Staack
AIMS: Translabial ultrasound (TUS) is a useful tool for identifying and assessing synthetic slings. This study evaluates the ability of urology trainees to learn basic pelvic anatomy and sling assessment on TUS. METHODS: Eight urology trainees (six residents and two medical students) received a lecture reviewing basic anatomy and sling assessment on TUS followed by review of two training cases. Next, they underwent a 126-question examination assessing their ability to identify anatomic planes and structures in those planes, identify the presence of slings, and assess the location and intactness of a sling...
February 10, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28181381/changes-in-penile-length-after-radical-prostatectomy-investigation-of-the-underlying-anatomical-mechanism
#13
Yoshifumi Kadono, Kazuaki Machioka, Kazufumi Nakashima, Masashi Iijima, Kazuyoshi Shigehara, Takahiro Nohara, Kazutaka Narimoto, Kouji Izumi, Yasuhide Kitagawa, Hiroyuki Konaka, Toshifumi Gabata, Atsushi Mizokami
OBJECTIVE: To measure changes in penile length (PL) over time before and after radical prostatectomy (RP), and to investigate the underlying mechanisms for these changes. PATIENTS AND METHODS: The stretched PL (SPL) of 102 patients was measured before, 10 days after, and at 1, 3, 6, 9, 12, 18 and 24 months after RP. The perpendicular distance from the distal end of the membranous urethra to the midline of the pelvic outlet was measured on mid-sagittal magnetic resonance imaging (MRI) slice at three time points: preoperatively; 10 days after RP; and 12 months after RP...
February 8, 2017: BJU International
https://www.readbyqxmd.com/read/28179160/tubular-collagen-scaffolds-with-radial-elasticity-for-hollow-organ-regeneration
#14
Luuk R Versteegden, Kenny A van Kampen, Heinz P Janke, Dorien M Tiemessen, Theo G Hafmans, Edwin A Roozen, Roger M Lomme, Harry van Goor, Egbert Oosterwijk, Wout F Feitz, Toin H van Kuppevelt, Willeke F Daamen
: Tubular collagen scaffolds have been used for the repair of damaged hollow organs in regenerative medicine, but they generally lack the ability to reversibly expand in radial direction, a physiological characteristic seen in many native tubular organs. In this study, tubular collagen scaffolds were prepared that display a shape recovery effect and therefore exhibit radial elasticity. Scaffolds were constructed by compression of fibrillar collagen around a star-shaped mandrel, mimicking folds in a lumen, a typical characteristic of empty tubular hollow organs, such as ureter or urethra...
February 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28177538/comparison-of-leak-pressures-for-single-layer-simple-continuous-suture-pattern-for-cystotomy-closure-using-barbed-and-monofilament-suture-material-in-an-ex-vivo-canine-model
#15
Nina R Kieves, Alexander I Krebs
OBJECTIVE: To compare leak pressures following simple continuous closure of cystotomy with barbed suture to an analogous monofilament suture, in an ex vivo canine model. STUDY DESIGN: Ex vivo, simple randomized study. ANIMALS OR SAMPLE POPULATION: Urinary bladders harvested from canine cadavers (n = 21). METHODS: Urinary bladders were harvested from cadavers immediately following euthanasia. A 3-cm cystotomy was made on ventral midline of the urinary bladder...
February 8, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28176530/effects-of-castration-on-penile-extracellular-matrix-morphology-in-domestic-cats
#16
Nathalia Cs Borges, Marco A Pereira-Sampaio, Vivian Alves Pereira, Marcelo Abidu-Figueiredo, Maurício Alves Chagas
Objectives This study was undertaken to verify the possible modifications caused by hormonal deprivation in the extracellular matrix in the penises of neutered cats. Methods Twenty-seven penises from domestic shorthair cats were collected: 14 samples from intact cats and 13 from neutered cats. Sections were stained with Weigert's resorcin-fuchsin, hematoxylin and eosin, and picrosirius red. Histomorphometric analysis was performed using light microscopy and image analysis software. The following parameters were analyzed: density of the elastic fibers and collagen fibers in the corpus spongiosum; density of the elastic fibers in the tunica albuginea of the corpus cavernosum and the tunica albuginea of the corpus spongiosum; luminal area of the urethra; area of the corpus spongiosum; area of the corpus cavernosum; and thickness of the urethral epithelium...
February 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28175975/prostatic-tissue-elimination-after-prostatic-artery-embolization-pae-a-report-of-three-cases
#17
Leandro Cardarelli Leite, Andre Moreira de Assis, Airton Mota Moreira, Sardis Honoria Harward, Alberto Azoubel Antunes, Francisco Cesar Carnevale
PURPOSE: We report three cases of spontaneous prostatic tissue elimination through the urethra while voiding following technically successful prostatic artery embolization (PAE) as a treatment for lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH). METHODS: All patients were embolized with 100- to 300-μm microspheres alone or in combination with 300- to 500-μm microspheres. RESULTS: During follow-up prior to eliminating the tissue fragments, the three patients all presented with intermittent periods of LUTS improvement and aggravation...
February 7, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28168722/androgen-deprivation-accelerates-the-prostatic-urethra-wound-healing-after-thulium-laser-resection-of-the-prostate-by-promoting-re-epithelialization-and-regulating-the-macrophage-polarization
#18
Xing-Jie Wang, Jian Zhuo, Guang-Heng Luo, Yi-Ping Zhu, Dian-Jun Yu, Rui-Zhe Zhao, Chen-Yi Jiang, Yun-Feng Shi, Hao Li, Lei Chen, Kui-Yuan Hao, Xia Han, Sheng Zhao, Xiao-Yu Bei, Yi-Feng Jing, Shu-Jie Xia
BACKGROUND: Complications after a thulium laser resection of the prostate (TmLRP) are related to re-epithelialization of the prostatic urethra. Since prostate growth and development are induced by androgen, the aim of this study was to determine the role and explore the mechanism of androgen in wound healing of the prostatic urethra. METHODS: Beagles that received TmLRPs were randomly distributed into a castration group, a testosterone undecanoate (TU) group, and a control group...
February 7, 2017: Prostate
https://www.readbyqxmd.com/read/28168411/potential-therapeutic-role-of-punicalagin-against-mechanical-trauma-induced-stress-urinary-incontinence-via-upregulation-of-nrf2-and-tgf-%C3%AE-1-signaling-effect-of-punicalagin-on-mechanical-trauma-induced-sui
#19
Jianming Tang, Cheng Liu, Jie Min, Ming Hu, Yang Li, Li Hong
INTRODUCTION AND HYPOTHESIS: We investigated the effect of punicalagin (PUN; 2,3-hexahydroxydiphenoyl-gallagyl-D-glucose), on mechanical-trauma-induced stress urinary incontinence (SUI) in mouse and the mechanisms underlying any effects. METHODS: Ninety virgin female C57BL/6 mice were randomized into six groups: five groups underwent vaginal distention (VD) for 1 h and leak-point pressure (LPP) was measured on the 1st, 3rd, 7th, 14th, and 28th day following (VD groups 1 d, 3 d, 7 d, 14 d, and 28 d)...
February 6, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28165009/acellular-urethra-bioscaffold-decellularization-of-whole-urethras-for-tissue-engineering-applications
#20
Irina N Simões, Paulo Vale, Shay Soker, Anthony Atala, Daniel Keller, Rute Noiva, Sandra Carvalho, Conceição Peleteiro, Joaquim M S Cabral, Daniel Eberli, Cláudia L da Silva, Pedro M Baptista
Patients with stress urinary incontinence mainly suffer from malfunction of the urethra closure mechanism. We established the decellularization of porcine urethras to produce acellular urethra bioscaffolds for future tissue engineering applications, using bioscaffolds or bioscaffold-derived soluble products. Cellular removal was evaluated by H&E, DAPI and DNA quantification. The presence of specific ECM proteins was assessed through immunofluorescence staining and colorimetric assay kits. Human skeletal muscle myoblasts, muscle progenitor cells and adipose-derived stromal vascular fractions were used to evaluate the recellularization of the acellular urethra bioscaffolds...
February 6, 2017: Scientific Reports
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