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https://www.readbyqxmd.com/read/29045596/the-relationship-between-cardiovascular-magnetic-resonance-imaging-measurement-of-extracellular-volume-fraction-and-clinical-outcomes-in-adults-with-repaired-tetralogy-of-fallot
#1
Kate Hanneman, Andrew M Crean, Bernd J Wintersperger, Paaladinesh Thavendiranathan, Elsie T Nguyen, Camilla Kayedpour, Rachel M Wald
Aims: Our aims were to explore cardiac magnetic resonance quantification of myocardial extracellular volume (ECV) in adults with repaired tetralogy of Fallot (rTOF) when compared with healthy controls and to investigate the association between ECV and major adverse cardiovascular outcomes. Methods and results: We prospectively recruited adults with rTOF (n = 44, 59% male, 32.9 ± 13.6 years) and evaluated right ventricular (RV) and left ventricular (LV) ECV by pre/post-gadolinium T1 measurements (modified Look-Locker inversion recovery technique) on a 1...
October 17, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29043373/correction-to-venoarterial-extracorporeal-membrane-oxygenation-for-refractory-cardiogenic-shock-post-cardiac-arrest
#2
Marc Pineton de Chambrun, Nicolas Bréchot, Guillaume Lebreton, Matthieu Schmidt, Guillaume Hekimian, Pierre Demondion, Jean-Louis Trouillet, Pascal Leprince, Jean Chastre, Alain Combes, Charles-Edouard Luyt
The second element of the first author's name was misinterpreted as a given name, whereas in fact it is part of his family name. The correct version of his name for indexing purposes is therefore M. Pineton de Chambrun (not M. P. de Chambrun).
October 17, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29034235/coagulofibrinolytic-changes-in-patients-with-post-cardiac-arrest-syndrome
#3
REVIEW
Takeshi Wada
Whole-body ischemia and reperfusion due to cardiac arrest and subsequent return of spontaneous circulation constitute post-cardiac arrest syndrome (PCAS), which consists of four syndromes including systemic ischemia/reperfusion responses and post-cardiac arrest brain injury. The major pathophysiologies underlying systemic ischemia/reperfusion responses are systemic inflammatory response syndrome and increased coagulation, leading to disseminated intravascular coagulation (DIC), which clinically manifests as obstruction of microcirculation and multiple organ dysfunction...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29033029/corrigendum-to-comparison-of-three-cognitive-exams-in-cardiac-arrest-survivors-resuscitation-116-2017-98-104
#4
Allison C Koller, Jon C Rittenberger, Melissa J Repine, Patrick W Morgan, Jeffrey Kristan, Clifton W Callaway
No abstract text is available yet for this article.
October 12, 2017: Resuscitation
https://www.readbyqxmd.com/read/29032299/association-of-antiplatelet-therapy-with-patient-outcomes-after-out-of-hospital-cardiac-arrest
#5
Alexandro Gianforcaro, Michael Kurz, Francis X Guyette, Clifton W Callaway, Jon C Rittenberger, Jonathan Elmer
BACKGROUND: Cessation of blood flow during out-of-hospital cardiac arrest (OHCA) results in microvascular thrombosis, protracted hypoperfusion after return of spontaneous circulation and damage to vital organs. We tested the hypothesis that pre-arrest antiplatelet and anticoagulant medication use would be associated with less post-arrest organ dysfunction and better outcomes. METHODS: We included OHCA patients treated from January 2005 to October 2014 at a single academic medical center...
October 11, 2017: Resuscitation
https://www.readbyqxmd.com/read/29026890/changes-in-histopathology-and-tumor-necrosis-factor-%C3%AE-levels-in-the-hearts-of-rats-following-asphyxial-cardiac-arrest
#6
Jung Hoon Lee, Tae-Kyeong Lee, In Hye Kim, Jae Chul Lee, Moo-Ho Won, Joon Ha Park, Ji Hyeon Ahn, Myoung Chul Shin, Taek Geun Ohk, Joong Bum Moon, Jun Hwi Cho, Chan Woo Park, Hyun-Jin Tae
OBJECTIVE: Post cardiac arrest (CA) syndrome is associated with a low survival rate in patients who initially have return of spontaneous circulation (ROSC) after CA. The aim of this study was to examine the histopathology and inflammatory response in the heart during the post CA syndrome. METHODS: We induced asphyxial CA in male Sprague-Dawley rats and determined the survival rate of these rats during the post resuscitation phase. RESULTS: Survival of the rats decreased after CA: 66...
September 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29017652/-hydrogen-can-alleviate-post-cardiac-arrest-myocardium-injury-in-rabbits
#7
Jingao Wang, Jiyan Lin, Minwei Zhang, Yujing He, Xiaowen Pan, Chengbin Yang, Dongmei Cai
OBJECTIVE: To investigate the effects of hydrogen (H2) on myocardium injury post-cardiac arrest (CA) in rabbits. METHODS: Sixty New Zealand rabbits were randomly divided into H2 treatment group (n = 30) and control group (n = 30) by random number table. The rabbit CA model was established by means of electrical stimulation of external membrane, both groups were mechanically ventilated. Cardiopulmonary resuscitation (CPR) was performed after 6 minutes of nonintervention, and stopped after restoration of spontaneous circulation (ROSC)...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29017648/-neurological-prognostic-value-of-gray-white-matter-ratio-in-patients-after-respiratory-and-cardiac-arrest
#8
Hengjun Liu, Peng Xu, Fei He, Yao Liu, Jun Wang
OBJECTIVE: To evaluate the role of gray-white-matter ratio (GWR) on neurological outcome in patients with coma after cardiopulmonary resuscitation (CPR) post-respiratory and cardiac arrest (CA). METHODS: Respiratory and CA patients with restoration of spontaneous circulation (ROSC) and coma after CPR admitted to Nanjing Drum Tower Hospital Clinical Medical College of Nanjing Medical University from February 2013 to June 2016 were enrolled. All patients were subjected to target temperature management (TTM) after CPR, and received cranial CT within 5 days after ROSC...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28990736/hospital-outcomes-of-transcatheter-versus-surgical-aortic-valve-replacement-in-female-in-the-united-states
#9
Tomo Ando, Emmanuel Akintoye, Tesfaye Telila, Alexandros Briasouolis, Hisato Takagi, Theodore Schreiber, Luis Afonso, Cindy L Grines
OBJECTIVES: To assess the in-hospital mortality and complications in female between transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR). BACKGROUND: Female is one of the risk factors for increased adverse events in cardiac surgery. METHODS AND RESULTS: Nationwide Inpatient Sample database was queried from 2011 to 2014 for patients who underwent TAVR or SAVR in female patients. The primary endpoint was in-hospital all-cause mortality and second endpoints were perioperative complications...
October 9, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28988962/prehospital-cooling-to-improve-successful-targeted-temperature-management-after-cardiac-arrest-a-randomized-controlled-trial
#10
D C Scales, S Cheskes, P R Verbeek, R Pinto, D Austin, S C Brooks, K N Dainty, K Goncharenko, M Mamdani, K E Thorpe, L J Morrison
RATIONALE: Targeted temperature management (TTM) improves survival with good neurological outcome after out-of-hospital cardiac arrest (OHCA), but is delivered inconsistently and often with delay. OBJECTIVE: To determine if prehospital cooling by paramedics leads to higher rates of 'successful TTM', defined as achieving a target temperature of 32-34°C within 6h of hospital arrival. METHODS: Pragmatic RCT comparing prehospital cooling (surface ice packs, cold saline infusion, wristband reminders) initiated 5min after return of spontaneous circulation (ROSC) versus usual resuscitation and transport...
October 5, 2017: Resuscitation
https://www.readbyqxmd.com/read/28986863/prognostic-implications-of-blood-lactate-concentrations-after-cardiac-arrest-a-retrospective-study
#11
Antonio Maria Dell'Anna, Claudio Sandroni, Irene Lamanna, Ilaria Belloni, Katia Donadello, Jacques Creteur, Jean-Louis Vincent, Fabio Silvio Taccone
BACKGROUND: Elevated lactate concentration has been associated with increased mortality after out-of-hospital cardiac arrest (CA). We investigated the variables associated with high blood lactate concentrations and explored the relationship between blood lactate and neurological outcome in this setting. METHODS: This was a retrospective analysis of an institutional database that included all adult (> 18 years) patients admitted to a multidisciplinary Department of Intensive Care between January 2009 and January 2013 after resuscitation from CA...
October 6, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28981338/heart-toxicity-related-to-herbs-and-dietary-supplements-online-table-of-case-reports-part-4-of-5
#12
Amy C Brown
BACKGROUND: The purpose of this review was to create an online research summary table of heart toxicity case reports related to dietary supplements (DS; includes herbs). METHODS: Documented PubMed case reports of DS appearing to contribute to heart-related problems were used to create a "Toxic Table" that summarized the research (1966 to April, 2016, and cross-referencing). Keywords included "herb," "dietary supplement," and cardiac terms. Case reports were excluded if they were herb combinations (some exceptions), Chinese herb mixtures, teas of mixed herb contents, mushrooms, poisonous plants, self-harm (e...
October 5, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28978554/association-of-pediatric-medical-emergency-teams-with-hospital-mortality
#13
Shelby Kutty, Philip G Jones, Quentin Karels, Navya Joseph, John A Spertus, Paul S Chan
Background -Implementation of a medical emergency teams has been identified as a potential strategy to reduce hospital deaths, as these teams respond to patients with acute physiological decline in an effort to prevent in-hospital cardiac arrest. However, prior studies of the association between medical emergency teams and hospital mortality have been limited and typically have not accounted for pre-implementation mortality trends. Methods -Within the Pediatric Health Information System (PHIS) for freestanding pediatric hospitals, annual risk-adjusted mortality rates were calculated for sites between 2000 and 2015...
October 4, 2017: Circulation
https://www.readbyqxmd.com/read/28974331/major-publications-in-the-critical-care-pharmacotherapy-literature-january-december-2016
#14
REVIEW
Deanna Horner, Diana Altshuler, Chris Droege, Joel Feih, Kevin Ferguson, Mallory Fiorenza, Kasey Greathouse, Leslie Hamilton, Caitlin Pfaff, Lauren Roller, Joanna Stollings, Adrian Wong
PURPOSE: To summarize select critical care pharmacotherapy guidelines and studies published in 2016. SUMMARY: The Critical Care Pharmacotherapy Literature Update (CCPLU) Group screened 31 journals monthly for relevant pharmacotherapy articles and selected 107 articles for review over the course of 2016. Of those included in the monthly CCPLU, three guidelines and seven primary literature studies are reviewed here. The guideline updates included are as follows: hospital-acquired pneumonia and ventilator-associated pneumonia management, sustained neuromuscular blocking agent use, and reversal of antithrombotics in intracranial hemorrhage (ICH)...
September 22, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28966156/long-term-clinical-outcomes-of-transient-and-persistent-no-reflow-following-percutaneous-coronary-intervention-pci-a-multi-center-australian-registry
#15
Stavroula Papapostolou, Nick Andrianopoulos, Stephen J Duffy, Angela L Brennan, Andrew E Ajani, David J Clark, Christopher M Reid, Melanie Freeman, Martin Sebastian, Laura Selkrig, Matias B Yudi, Samer Q Noaman, William Chan
AIMS: To evaluate long-term outcomes of transient versus persistent no-reflow. METHODS AND RESULTS: 17,547 patients with normal flow post percutaneous coronary intervention (PCI) were compared to 590 patients (3.2%) with transient no-reflow and 144 patients (0.8%) with persistent no-reflow. Long-term all-cause mortality was obtained by linkage with the National Death Index (NDI). No-reflow patients were more likely to have presented with ST-elevation myocardial infarction (STEMI), out-of-hospital cardiac arrest (OHCA) or cardiogenic shock (all p<0...
October 3, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28962216/assessing-the-impact-of-total-extracorporeal-circulation-on-hemodynamics-in-an-ovine-fetal-model
#16
Fei Xiao, Jian Zhuang, Cheng-Bin Zhou, Ji-Mei Chen, Jian-Zheng Cen, Gang Xu, Shu-Sheng Wen
The present study aimed to evaluate the impact of total extracorporeal circulation on hemodynamics and placental function in an ovine fetal model. Mid-term ovine fetuses (n=6) underwent extracorporeal circulation (30 min), cardioplegic arrest (20 min) and monitoring (120 min). The ascending aorta and umbilical cords of the fetuses were occluded during the bypass and an extracorporeal membrane oxygenator was used as the oxygen source. Biventricular intracardiac pressures, echocardiographic data, blood gas levels and placental function variables were recorded, and statistical analysis was performed using the repeated-measure analysis of variance test...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28957432/intranasal-post-cardiac-arrest-treatment-with-orexin-a-facilitates-arousal-from-coma-and-ameliorates-neuroinflammation
#17
Hiren R Modi, Qihong Wang, Sahithi Gd, David Sherman, Elliot Greenwald, Alena V Savonenko, Romergryko G Geocadin, Nitish V Thakor
Cardiac arrest (CA) entails significant risks of coma resulting in poor neurological and behavioral outcomes after resuscitation. Significant subsequent morbidity and mortality in post-CA patients are largely due to the cerebral and cardiac dysfunction that accompanies prolonged whole-body ischemia post-CA syndrome (PCAS). PCAS results in strong inflammatory responses including neuroinflammation response leading to poor outcome. Currently, there are no proven neuroprotective therapies to improve post-CA outcomes apart from therapeutic hypothermia...
2017: PloS One
https://www.readbyqxmd.com/read/28955127/oxidative-stress-and-abnormal-cholesterol-metabolism-in-patients-with-post-cardiac-arrest-syndrome
#18
Midori Nagase, Atsushi Sakurai, Atsunori Sugita, Nozomi Matsumoto, Airi Kubo, Yusuke Miyazaki, Kosaku Kinoshita, Yorihiro Yamamoto
Patients with post-cardiac arrest syndrome (PCAS) suffer from whole body ischemia/reperfusion injury similar to that experienced by newborn babies. Increased oxidative stress was confirmed in PCAS patients (n = 40) at the time of hospitalization by a significant increase in the percentage of the oxidized form of coenzyme Q10 in total coenzyme Q10 compared to age-matched healthy controls (n = 55). Tissue oxidative damage in patients was suggested by the significant increase in plasma levels of free fatty acids (FFA) and the significant decrease in polyunsaturated fatty acid contents in total FFA...
September 2017: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/28950909/systemic-impact-on-secondary-brain-aggravation-due-to-ischemia-reperfusion-injury-in-post-cardiac-arrest-syndrome-a-prospective-observational-study-using-high-mobility-group-box-1-protein
#19
Atsunori Sugita, Kosaku Kinoshita, Atsushi Sakurai, Nobutaka Chiba, Junko Yamaguchi, Tsukasa Kuwana, Nami Sawada, Satoshi Hori
BACKGROUND: Ischemia/reperfusion injury (I/R) is an important pathophysiology of post-cardiac arrest syndrome (PCAS) against multiple organ dysfunction and mortality. The inflammatory response in PCAS causes systemic I/R. The purpose of this study was to demonstrate the pathophysiology of systemic I/R for secondary brain damage using the biomarkers high-mobility group box 1 (HMGB1), neuron-specific enolase (NSE), and interleukin-6 (IL-6). METHODS: This study was designed as a single-institution prospective observational study...
September 26, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28948850/the-impact-of-airway-strategy-on-the-patient-outcome-after-out-of-hospital-cardiac-arrest-a-propensity-score-matched-analysis
#20
Patrick Sulzgruber, Philip Datler, Fritz Sterz, Michael Poppe, Elisabeth Lobmeyr, Markus Keferböck, Sebastian Zeiner, Alexander Nürnberger, Andreas Schober, Pia Hubner, Peter Stratil, Christian Wallmueller, Christoph Weiser, Alexandra-Maria Warenits, Andreas Zajicek, Florian Ettl, Ingrid Magnet, Thomas Uray, Christoph Testori, Raphael van Tulder
BACKGROUND: While guidelines mentioned supraglottic airway management in the case of out-of- hospital cardiac arrest, robust data of their impact on the patient outcome remain scare and results are inconclusive. METHODS: To assess the impact of the airway strategy on the patient outcome we prospectively enrolled 2224 individuals suffering cardiac arrest who were treated by the Viennese municipal emergency medical service. To control for potential confounders, propensity score matching was performed...
September 1, 2017: European Heart Journal. Acute Cardiovascular Care
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