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https://www.readbyqxmd.com/read/28747938/computed-tomography-angiography-for-imaging-results-of-neochordal-mitral-valve-repair
#1
Radosław Zwoliński, Anna Marcinkiewicz, Konrad Szymczyk, Jarosław Drożdż, Ryszard Jaszewski, Bogdan Jegier
INTRODUCTION: Degenerative mitral regurgitation is currently the most frequent indication for mitral valve repair. AIM: To visualize and assess the mid-term results of mitral valve repair with neochordae implantation, using computed tomography angiography (CTA) imaging. MATERIAL AND METHODS: The CTA with ECG gating and without modulation was applied in 10 patients to assess the results of a mitral valve sparing procedure. The results of 3 patients are presented...
June 2017: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28747392/evaluation-of-grading-systems-in-stage-i-lung-adenocarcinomas-a-retrospective-cohort-study
#2
Tamás Zombori, József Furák, Tibor Nyári, Gábor Cserni, László Tiszlavicz
AIMS: There is no internationally accepted grading system for lung adenocarcinoma despite the new WHO classification. The architectural grade, the Kadota grade and the Sica score were evaluated and compared with overall (OS) and disease-free survival (DFS). METHODS: Comprehensive histological subtyping was used in a series of resected stage I lung adenocarcinoma to identify subtypes of adenocarcinomas, the architectural grade, the Kadota grade, the Sica grade, the mitotic count, nuclear atypia, the presence of lymphovascular, vascular and airway propagation, necrosis, and micropapillary or solid growth pattern in any percentage...
July 26, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28747133/retroperitoneal-laparoscopic-nephrotomy-along-the-brodel-line-and-tumor-enucleation-te-for-complete-intra-parenchymal-renal-tumors-a-single-institution-experience
#3
Baojun Wang, Huijie Gong, Xin Ma, Hong Zhao Li, Yongji Yan, Wei Cai, Lixin Shi, Xintao Li, Xu Zhang
PURPOSE: To evaluate the feasibility and outcomes of retroperitoneal laparoscopic nephrotomy along the Brodel line and tumor enucleation (TE) for complete intra-parenchymal renal tumors. PATIENTS AND METHODS: We retrospectively analysed the medical charts of patients with complete endophytic tumors and who underwent retroperitoneal laparoscopic nephrotomy along the Brodel line and TE between 2012 and 2015. Peri-operative data, surgical technique, pathological variables, complications, functional and oncological outcomes were reviewed...
July 26, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28746753/letter-to-the-editor-reply-to-ultrasonography-and-cytology-as-predictors-of-noninvasive-follicular-thyroid-niftp-neoplasm-with-papillary-like-nuclear-features-importance-of-the-differential-diagnosis-with-the-invasive-encapsulated-follicular-variant-of-papillary
#4
Jung Hee Shin
As Dr. Rosario pointed out, it might be more useful to differentiate NIFTP from invasive encapsulated follicular variant of papillary thyroid carcinoma (iE-FVPTC), not from infiltrative FVPTC (I-FVPTC) in clinical setting since infiltrative FVPTCs show overt malignant US features more frequently. However, in the previous study, we attempted to describe the characteristic ultrasound (US) features and diagnostic method of NIFTP specifically. This article is protected by copyright. All rights reserved.
July 26, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28746205/nomograms-predicting-disease-specific-regional-recurrence-and-distant-recurrence-of-papillary-thyroid-carcinoma-following-partial-or-total-thyroidectomy
#5
Ming-Hua Ge, Jun Cao, Jin-Yu Wang, Yu-Qing Huang, Xia-Bin Lan, Bin Yu, Qing-Liang Wen, Xiu-Jun Cai
The study aimed to establish effective nomograms for prediction of tumor regional recurrence and distant recurrence of papillary thyroid carcinoma (PTC) patients after partial or total thyroidectomy.These nomograms were based on a retrospective study on 1034 patients who underwent partial or total thyroidectomy for PTC. The predictive accuracy and discriminative ability of the nomograms were evaluated by the concordance index (C-index) and calibration curve. In addition, a validation cohort was included at the same institution...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28744974/obestatin-regulates-cardiovascular-function-and-promotes-cardioprotection-through-the-nitric-oxide-pathway
#6
Claudia Penna, Francesca Tullio, Saveria Femminò, Carmine Rocca, Tommaso Angelone, Maria C Cerra, Maria Pia Gallo, Iacopo Gesmundo, Alessandro Fanciulli, Maria Felice Brizzi, Pasquale Pagliaro, Giuseppe Alloatti, Riccarda Granata
Patients with ischaemic heart disease or chronic heart failure show altered levels of obestatin, suggesting a role for this peptide in human heart function. We have previously demonstrated that GH secretagogues and the ghrelin gene-derived peptides, including obestatin, exert cardiovascular effects by modulating cardiac inotropism and vascular tone, and reducing cell death and contractile dysfunction in hearts subjected to ischaemia/reperfusion (I/R), through the Akt/nitric oxide (NO) pathway. However, the mechanisms underlying the cardiac actions of obestatin remain largely unknown...
July 26, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28744725/impact-of-major-different-variants-of-papillary-thyroid-microcarcinoma-on-the-clinicopathological-characteristics-the-study-of-1041-cases
#7
Jingtai Zhi, Jingzhu Zhao, Ming Gao, Yi Pan, Jianghua Wu, Yigong Li, Dapeng Li, Yang Yu, Xiangqian Zheng
BACKGROUND: The incidence of papillary thyroid microcarcinoma (PTMC) has been increasing globally in the past few decades. PTMC does not have a distinctive morphology that results in differences in biological behavior. The aim of this study was to classify PTMCs according to the morphological features and explore the relationship with clinicopathological characteristics. Additionally, we sought to evaluate whether different variants of PTMC can be an independent predictor for lymph mode metastasis when considering other risk factors...
July 25, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28742856/fit-for-genomic-and-proteomic-purposes-sampling-the-fitness-of-nucleic-acid-and-protein-derivatives-from-formalin-fixed-paraffin-embedded-tissue
#8
Anna Yakovleva, Jordan L Plieskatt, Sarah Jensen, Razan Humeida, Jonathan Lang, Guangzhao Li, Paige Bracci, Sylvia Silver, Jeffrey Michael Bethony
The demand for nucleic acid and protein derivatives from formalin-fixed paraffin-embedded (FFPE) tissue has greatly increased due to advances in extraction and purification methods, making these derivatives available for numerous genomic and proteomic platforms. Previously, DNA, RNA, microRNA (miRNA), or protein derived from FFPE tissue blocks were considered "unfit" for such platforms, as the process of tissue immobilization by FFPE resulted in cross-linked, fragmented, and chemically modified macromolecules...
2017: PloS One
https://www.readbyqxmd.com/read/28742421/comparison-of-30-mci-and-50-mci-i-131-doses-for-ablation-of-thyroid-remnant-in-papillary-thyroid-cancer-patients
#9
Xiao Yue Cai, Niranjan Vijayaratnam, Alexander J B McEwan, Rebecca Reif, Donald W Morrish
PURPOSE OF THE STUDY: To compare efficacy of thyroid remnant ablation using 30 mCi or 50 mCi 131-I in papillary thyroid cancer patients. MATERIALS AND METHODS: Five hundred and fifteen consecutive patients with Tumor-Node-Metastasis (TNM) stages T1-T3 N1/N0/NX receiving either 30 mCi or 50 mCi I-131 were analyzed for the effectiveness of remnant ablation using rhTSH-stimulated serum thyroglobulin. One hundred and five consecutive patients receiving 100 mCi I-131 were analyzed for the incidence of radiation thyroiditis and sialadenitis...
July 25, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28741452/young-age-and-male-sex-can-predict-for-a-large-volume-central-neck-lymph-node-metastasis-in-clinical-n0-papillary-thyroid-microcarcinoma
#10
Hye-Seon Oh, Suyeon Park, Mijin Kim, Hyemi Kwon, Eyun Song, Tae-Yon Sung, Yu-Mi Lee, Won Gu Kim, Tae Yong Kim, YoungKee Shong, Won Bae Kim, MinJi Jeon
<b><i>Background</i></b> Large-volume lymph node metastasis (LNM) is associated with poor clinical outcomes in papillary thyroid microcarcinoma (PTMC) patients. However, sensitivity in the detection of central neck LNM on preoperative neck ultrasonography (US) is believed to be low. The aim of this study is to investigate the preoperative clinical factors associated with large volume LNM in clinical N0 PTMC patients. <b><i>Methods</i></b> In all, 2329 clinical N0 PTMC patients who underwent total thyroidectomy with prophylactic central lymph node (LN) dissection were evaluated...
July 25, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28741199/radioactive-iodine-ablation-decrease-recurrences-in-papillary-thyroid-microcarcinoma-with-lateral-lymph-node-metastasis-in-chinese-patients
#11
Shuai Xue, Peisong Wang, Jia Liu, Guang Chen
INTRODUCTION: We aimed to carry out a retrospective study from a single institution to determine whether radioactive iodine (RAI) ablation decreases the risk of recurrence of papillary thyroid microcarcinoma (PTMC) patients that presented with lateral lymph node metastasis (LLNM). METHODS: We retrospectively analyzed a total of 6361 consecutive PTMC patients who initially underwent surgery for the treatment of thyroid carcinoma at the First Hospital of Jilin University, between January 2005 and February 2015...
July 24, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28740720/analysing-the-reasons-of-failure-of-surgical-mitral-repair-approaches-do-we-need-to-better-think-in-biomechanics
#12
Massimiliano Fraldi, Cristiano Spadaccio, Christos G Mihos, Francesco Nappi
The failure of mitral valve repair procedures revealed in the outcomes of the recent randomized studies is suggesting the necessity for a better understanding of the biomechanical mechanisms underlying the failure of the surgical approaches. Use of biomechanical modelling and finite element analysis (FEA) in cardiovascular research is an important aid in this context. In our group we developed a biomechanical model taking into account all the component of the mitral valve functional unit including the valve leaflets, the annulus, the papillary muscles, the chordae tendinea and the ventricular geometry...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740718/papillary-muscle-approximation-in-mitral-valve-repair-for-secondary-mr
#13
REVIEW
Francesco Nappi, Cristiano Spadaccio, Massimo Chello, Christos G Mihos
Ischemic mitral regurgitation (IMR) is a complex disorder occurring after a myocardial infarction and affecting both the mitral valvular and subvalvular apparati. Several abnormalities can be detected in IMR as annular dilatation, leaflet tethering with impaired coaptation and papillary muscle (PM) displacement along a posterior, apical or lateral vectors. Treatments available include, beside myocardial revascularization, mitral-valve repair or chordal-sparing replacement. Repair is normally achieved downsizing the mitral valve annulus with a rigid or semirigid ring...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740716/biomechanics-raises-solution-to-avoid-geometric-mitral-valve-configuration-abnormalities-in-ischemic-mitral-regurgitation
#14
REVIEW
Francesco Nappi, Cristiano Spadaccio, Christos G Mihos, Massimiliano Fraldi
Ischemic mitral regurgitation (IMR) is a form of mitral insufficiency that is characterized by papillary muscle (PM) displacement, leaflet tethering, reduced closing forces, and different degree of annular dilatation. Treatment of this condition includes mitral valve replacement or mitral valve repair with restrictive annuloplasty. Recent evidences in mitral valve repair showed that addressing only the annulus and neglecting the subvalvular apparatus provides a suboptimal operation with poor long-term results...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740711/mitral-valve-repair-and-subvalvular-intervention-for-secondary-mitral-regurgitation-a-systematic-review-and-meta-analysis-of-randomized-controlled-and-propensity-matched-studies
#15
Christos G Mihos, Steve Xydas, Evin Yucel, Romain Capoulade, Roy F Williams, Maurice Mawad, Guillermo Garcia, Orlando Santana
BACKGROUND: Combining a ring annuloplasty (Ring) with a mitral subvalvular intervention (Ring + subvalvular) in patients with secondary mitral regurgitation (MR) may improve mitral valve (MV) repair durability. However, the outcomes of this strategy compared with a Ring only, have not been clearly defined. METHODS: A systematic review and meta-analysis was performed utilizing randomized controlled and propensity matched studies which compared a Ring + subvalvular versus Ring MV repair for the treatment of secondary MR...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740633/papillary-fibroelastoma-arising-from-the-coumadin-ridge
#16
Mahim Malik, Konstantin Shilo, Ahmet Kilic
Cardiac papillary fibroelastomas (CPF) are rare cardiac tumors, mostly found on the valvular surfaces in the heart. These tumors are frond like in nature and are benign, intracardiac masses, rarely causing any hemodynamic disturbances. However, excision of these masses is indicated due to their propensity to embolize. We present a case report of the tumor found on the coumadin ridge, causing transient ischemic attacks in a patient. We performed complete excision of the tumor via median sternotomy on cardiopulmonary bypass support with cardiac arrest...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28740507/mir-195-inhibits-tumor-growth-and-metastasis-in-papillary-thyroid-carcinoma-cell-lines-by-targeting-ccnd1-and-fgf2
#17
Yali Yin, Shubin Hong, Shuang Yu, Yanrui Huang, Shuwei Chen, Yujie Liu, Quan Zhang, Yanbing Li, Haipeng Xiao
BACKGROUND: MicroRNA (miRNA) dysregulation was commonly seen in papillary thyroid carcinoma (PTC), and miR-195 was verified to be downregulated in PTC by the large data set analysis from The Cancer Genome Atlas (TCGA). Our study aimed to explore the biological functions and the underlying molecular mechanisms of miR-195 in PTC. METHODS: The relative expression of miR-195 and its target genes were assessed by quantitative RT-PCR assay in 38 pairs of PTC and the adjacent thyroid tissues...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28739282/long-term-risk-of-pancreatic-malignancy-in-patients-with-branch-duct-intraductal-papillary-mucinous-neoplasm-in-a-referral-center
#18
Ilaria Pergolini, Klaus Sahora, Cristina R Ferrone, Vicente Morales-Oyarvide, Brian M Wolpin, Lorelei A Mucci, William R Brugge, Mari Mino-Kenudson, Manuel Patino, Dushyant V Sahani, Andrew L Warshaw, Keith D Lillemoe, Carlos Fernández-Del Castillo
BACKGROUND & AIMS: Little is known about development of branch duct intraductal papillary mucinous neoplasms (BD-IPMNs). We evaluated long-term outcomes of a large cohort of patients with BD-IPMNs to determine risk of malignancy and define a subset of low-risk BD-IPMNs. METHODS: We performed a retrospective analysis of data from 577 patients with suspected or presumed BD-IPMN under surveillance at the Massachusetts General Hospital. Patients underwent cross-sectional imaging analysis at 3 months or later after their initial diagnosis...
July 21, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28739154/prostaglandin-e2-a-pancreatic-fluid-biomarker-of-intraductal-papillary-mucinous-neoplasm-dysplasia
#19
Michele T Yip-Schneider, Rosalie A Carr, Huangbing Wu, C Max Schmidt
BACKGROUND: With the increased frequency of diagnostic imaging, pancreatic cysts are now detected in >3% of American adults. Most of these are intraductal papillary mucinous neoplasm (IPMN) with well-established but variable malignant potential. A biomarker that predicts malignant potential or dysplastic grade would help determine which IPMN require removal or can be safely observed. We previously reported that pancreatic fluid prostaglandin E2 (PGE2) levels may have promise as a predictor of IPMN dysplasia and seek to validate these results in the current study...
July 21, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28738880/level-of-mitoses-in-non-muscle-invasive-papillary-urothelial-carcinomas-pta-and-pt1-at-initial-bladder-biopsy-is-a-simple-and-powerful-predictor-of-clinical-outcome-a-multi-center-study-in-south-korea
#20
Ji Eun Kwon, Nam Hoon Cho, Yeong-Jin Choi, So Dug Lim, Yong Mee Cho, Sun Young Jun, Sanghui Park, Young A Kim, Sung-Sun Kim, Mi Sun Choe, Jung-Dong Lee, Dae Yong Kang, Jae Y Ro, Hyun-Jung Kim
BACKGROUND: Histologic grade is the most important predictor of the clinical outcome of non-muscle invasive (Ta, T1) papillary urothelial carcinoma (NMIPUCa), but its ambiguous criteria diminish its power to predict recurrence/progression for individual patients. We attempted to find an objective and reproducible histologic predictor of NMIPUCa that correlates well with the clinical outcome. METHODS: A total of 296 PUCas were collected from the Departments of Surgical Pathology of 11 institutions in South Korea...
July 24, 2017: Diagnostic Pathology
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