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https://www.readbyqxmd.com/read/27896922/-epigallocatechin-3-gallate-antihyperalgesic-effect-associates-with-reduced-cx3cl1-chemokine-expression-in-spinal-cord
#1
Marc Bosch-Mola, Judit Homs, Beltrán Álvarez-Pérez, Teresa Puig, Francisco Reina, Enrique Verdú, Pere Boadas-Vaello
(-)-Epigallocatechin-3-gallate (EGCG) is a major polyphenol in green tea with beneficial effects on the neuropathic pain alleviation in animal models. Because chemokine fractalkine (CX3CL1) has been suggested as an important signal during neuropathic pain development, this study aimed to investigate whether CX3CL1 expression may be modulated by EGCG treatment reducing hyperalgesia in chronic constriction injured mice. To this end, Balb/c mice were subjected to a chronic constriction injury of sciatic nerve (CCI) and treated with EGCG or vehicle once a day during the first week following surgery...
November 29, 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/27894002/polymorphism-in-crhr1-gene-affects-the-il-1%C3%AE-levels-in-suicidal-attempters
#2
Clarissa R Bastos, Marta Gazal, Luciana de A Quevedo, Joice Luisa Costa, Carolina D Wiener, Karen Jansen, Christian Loret de Mola, Jean P Oses, Luciano D M Souza, Luiz Valmor Portela, Ricardo T Pinheiro, Ricardo A da Silva, Diogo R Lara, Gabriele Ghisleni
Approximately one million people commit suicide every year, being suicide attempts and ideation even more common. Changes in stress response and activation of the immune system have been associated with suicide risk. Here we investigated the interaction between immune system and HPA axis alterations in the suicide risk, looking for the influence of rs110402 CRHR1 SNP in the IL-1β levels according to suicide ideation and attempt. This study evaluated 171 subjects of which 15 had suicidal ideation, 20 had suicide attempt and 136 were controls...
November 18, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27890353/anxiety-and-nicotine-dependence-emerging-role-of-the-habenulo-interpeduncular-axis
#3
REVIEW
Susanna Molas, Steven R DeGroot, Rubing Zhao-Shea, Andrew R Tapper
While innovative modern neuroscience approaches have aided in discerning brain circuitry underlying negative emotional behaviors including fear and anxiety responses, how these circuits are recruited in normal and pathological conditions remains poorly understood. Recently, genetic tools that selectively manipulate single neuronal populations have uncovered an understudied circuit, the medial habenula (mHb)-interpeduncular (IPN) axis, that modulates basal negative emotional responses. Interestingly, the mHb-IPN pathway also represents an essential circuit that signals heightened anxiety induced by nicotine withdrawal...
November 24, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27866338/reflections-on-serving-remote-mountain-communities-mobile-hospitals-and-women-s-and-children-s-health-care-in-northern-haiti
#4
Rose-Marie Chierici, Thony Michelet Voltaire
In 2003 Alyans Sante Borgne's (ASB) conducted the first week-long mobile hospital in Molas, a poor mountain community a 10-h walk from the main hospital in the town of Borgne in North Haiti. ASB is a partnership between Haiti Outreach-Pwoje Espwa (H.O.P.E.), a US-based NGO, and Haiti's Ministry of Health. The paper reflects on this first experience and the evolution of an indigenous model of health care delivery, Sante Nan Lakou (SNL)/Health at the Extended Family Level, a model that prioritizes the needs of patients over those of the institution...
November 19, 2016: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/27783630/sex-linked-chromosome-heterozygosity-in-males-of-tityus-confluens-buthidae-a-clue-about-the-presence-of-sex-chromosomes-in-scorpions
#5
Renzo Sebastián Adilardi, Andrés Alejandro Ojanguren-Affilastro, Liliana María Mola
Scorpions of the genus Tityus show holokinetic chromosomes, achiasmatic male meiosis and an absence of heteromorphic sex chromosomes, like all Buthidae. In this work, we analysed the meiotic behaviour and chromosome rearrangements of a population of the scorpion Tityus confluens, characterising the cytotypes of males, females and embryos with different cytogenetic techniques. This revealed that all the females were structural homozygotes, while all the males were structural heterozygotes for different chromosome rearrangements...
2016: PloS One
https://www.readbyqxmd.com/read/27765209/cultivar-classification-of-apulian-olive-oils-use-of-artificial-neural-networks-for-comparing-nmr-nir-and-merceological-data
#6
Giulio Binetti, Laura Del Coco, Rosa Ragone, Samanta Zelasco, Enzo Perri, Cinzia Montemurro, Raffaele Valentini, David Naso, Francesco Paolo Fanizzi, Francesco Paolo Schena
The development of an efficient and accurate method for extra-virgin olive oils cultivar and origin authentication is complicated by the broad range of variables (e.g., multiplicity of varieties, pedo-climatic aspects, production and storage conditions) influencing their properties. In this study, artificial neural networks (ANNs) were applied on several analytical datasets, namely standard merceological parameters, near-infra red data and (1)H nuclear magnetic resonance (NMR) fingerprints, obtained on mono-cultivar olive oils of four representative Apulian varieties (Coratina, Ogliarola, Cima di Mola, Peranzana)...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27720598/giant-reed-growth-and-effects-on-soil-biological-fertility-in-assisted-phytoremediation-of-an-industrial-polluted-soil
#7
N Fiorentino, V Ventorino, C Rocco, V Cenvinzo, D Agrelli, L Gioia, I Di Mola, P Adamo, O Pepe, M Fagnano
Phytoremediation is a cost-effective "green technology" that uses plants to improve the soil properties of polluted sites, preventing the dispersion of pollutants and reducing the mobility of potentially toxic elements (PTEs) through their adsorption and accumulation by roots or precipitation within the root zone. Being highly tolerant to pollutants and other abiotic stresses, giant reed (Arundo donax L.) is a suitable biomass crop for phytoremediation of contaminated soils. We report the results of a two-year open-air lysimeter study aimed at assessing the adaptability of giant reed to grow on industrial substrates polluted by Pb and Zn and at testing commercial humic acids from leonardite as improvers of plant performance...
October 6, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27720293/synthesis-and-pharmacological-evaluation-of-functionalized-isoindolinones-on-gaba-activated-chloride-currents-in-rat-cerebellum-granule-cells-in-culture
#8
Antonia Di Mola, Elena Gatta, Carmen Petronzi, Aroldo Cupello, Paolo De Caprariis, Mauro Robello, Antonio Massa, Rosanna Filosa
A focused N-substituted 3-(2-piperazin-1-yl-2-oxoethyl)-2-(pyridin-2-yl)iso-indolin-1-ones small library was synthesized for modulation of GABA-A receptor function and compared to Zopiclone for the ability to increase GABA-activated chloride currents. All compounds were tested for their effects on GABA-activated chloride currents in rat cerebellar granule cells by use of the whole-cell patch clamp technique. Electrophysiological studies on cultured cerebellar granule cells revealed 3-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-2-(5-nitropyridin-2-yl)iso-indolin-1-one (Id) as a partial agonist displaying 34% increase of the 10μM GABA evoked peak chloride currents, antagonized by flumazenil...
September 15, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27699273/cns-directed-gene-therapy-for-the-treatment-of-neurologic-and-somatic-mucopolysaccharidosis-type-ii-hunter-syndrome
#9
Sandra Motas, Virginia Haurigot, Miguel Garcia, Sara Marcó, Albert Ribera, Carles Roca, Xavier Sánchez, Víctor Sánchez, Maria Molas, Joan Bertolin, Luca Maggioni, Xavier León, Jesús Ruberte, Fatima Bosch
Mucopolysaccharidosis type II (MPSII) is an X-linked lysosomal storage disease characterized by severe neurologic and somatic disease caused by deficiency of iduronate-2-sulfatase (IDS), an enzyme that catabolizes the glycosaminoglycans heparan and dermatan sulphate. Intravenous enzyme replacement therapy (ERT) currently constitutes the only approved therapeutic option for MPSII. However, the inability of recombinant IDS to efficiently cross the blood-brain barrier (BBB) limits ERT efficacy in treating neurological symptoms...
June 16, 2016: JCI Insight
https://www.readbyqxmd.com/read/27696435/comparison-of-two-apheresis-systems-for-autologous-stem-cell-collections-in-pediatric-oncology-patients
#10
Ehud Even-Or, Alexandra Eden-Walker, Maria Di Mola, Elizabeth McDougall, Tal Schechter, Muhammad Ali, Gordana Svajger, Adam Gassas, Christoph Licht, Joerg Krueger
BACKGROUND: Peripheral stem cell collections can be challenging in the pediatric population and respective experience is limited. Since February 2015 our institution is utilizing the new Spectra Optia (Optia) apheresis device, which has replaced the former COBE Spectra (COBE) device. As a quality initiative we collected and compared collection efficiency (CE2) and other collection variables between the two devices. STUDY DESIGN AND METHODS: In this retrospective study we collected and compared clinical, laboratory, and technical collection data from stem cell collection procedures done with the Optia and COBE devices...
October 3, 2016: Transfusion
https://www.readbyqxmd.com/read/27686630/psychometric-testing-of-the-self-care-of-coronary-heart-disease-inventory-sc-chdi
#11
Victoria Vaughan Dickson, Christopher S Lee, Karen S Yehle, Ana Mola, Kenneth M Faulkner, Barbara Riegel
Although coronary heart disease (CHD) requires a significant amount of self-care, there are no instruments available to measure self-care in this population. The purpose of this study was to test the psychometric properties of the Self-Care of Coronary Heart Disease Inventory (SC-CHDI). Using the Self-Care of Chronic Illness theory, we developed a 22-item measure of maintenance, management, and confidence appropriate for persons with stable CHD and tested it in a convenience sample of 392 adults (62% male, mean age 61...
September 30, 2016: Research in Nursing & Health
https://www.readbyqxmd.com/read/27682151/growth-and-characterization-of-v2-o5-thin-film-on-conductive-electrode
#12
Genene T Mola, Elhadi A A Arbab, Bidini A Taleatu, K Kaviyarasu, Ishaq Ahmad, M Maaza
Vanadium pentoxide V2 O5 thin films were grown at room temperature on ITO coated glass substrates by electrochemical deposition. The resulting films were annealed at 300, 400 and 500°C for 1 h in ambient environment. The effect of heat treatment on the films properties such as surface morphology, crystal structure, optical absorption and photoluminescence were investigated. The x-ray diffraction study showed that the films are well crystallized with temperatures. Strong reflection from plane (400) indicated the film's preferred growth orientation...
September 29, 2016: Journal of Microscopy
https://www.readbyqxmd.com/read/27658433/-fingolimod-effectiveness-and-safety-in-routine-clinical-practice-an-observational-retrospective-multi-centre-study-in-the-province-of-alicante
#13
J Mallada, N Perez-Carmona, L Berenguer-Ruiz, R Sanchez-Perez, R Martin-Gonzalez, D Sola-Martinez, S Mola, J M Lopez-Arlandis, R Vela-Yebra, L Gabaldon-Torres, E Freire-Alvarez, A Garcia-Escriva, A P Sempere
INTRODUCTION: Post-authorisation studies are important to confirm whether the outcomes of clinical trials are reproduced in usual clinical practice. AIMS: To evaluate the effectiveness and safety of fingolimod in clinical practice in the province of Alicante. PATIENTS AND METHODS: A retrospective multi-centre study was conducted with remitting multiple sclerosis patients treated with fingolimod. Demographic, clinical and pharmacological data were collected...
September 5, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27629483/borderline-resectable-pancreatic-cancer-and-the-role-of-neoadjuvant-chemoradiotherapy
#14
REVIEW
Pierluigi di Sebastiano, Tommaso Grottola, F Francesco di Mola
Borderline resectable pancreatic cancer is now recognized as a distinct clinical entity. In these cases, neoadjuvant treatment could maximize the potential for an R0 resection and avoid R1/R2 resections. In fact, by analyzing, the current literature is evident that approximately one-third of initially borderline resectable pancreatic tumors may undergo successful resection following neoadjuvant therapy. However, the enormous difficulties in achieving a consensus and the variability in therapeutic algorithms have delayed progress in establishing strong evidence-based practices for diagnosis and treatment...
September 2016: Updates in Surgery
https://www.readbyqxmd.com/read/27620135/custom-sample-environments-at-the-alba-xpeem
#15
Michael Foerster, Jordi Prat, Valenti Massana, Nahikari Gonzalez, Abel Fontsere, Bernat Molas, Oscar Matilla, Eric Pellegrin, Lucia Aballe
A variety of custom-built sample holders offer users a wide range of non-standard measurements at the ALBA synchrotron PhotoEmission Electron Microscope (PEEM) experimental station. Some of the salient features are: an ultrahigh vacuum (UHV) suitcase compatible with many offline deposition and characterization systems, built-in electromagnets for uni- or biaxial in-plane (IP) and out-of-plane (OOP) fields, as well as the combination of magnetic fields with electric fields or current injection. Electronics providing a synchronized sinusoidal signal for sample excitation enable time-resolved measurements at the 500MHz storage ring RF frequency...
August 30, 2016: Ultramicroscopy
https://www.readbyqxmd.com/read/27616965/early-discharge-planning-and-improved-care-transitions-pre-admission-assessment-for-readmission-risk-in-an-elective-orthopedic-and-cardiovascular-surgical-population
#16
Brenda Ohta, Ana Mola, Peri Rosenfeld, Shauna Ford
BACKGROUND/METHODS: Readmission prevention is a marker of patient care quality and requires comprehensive, early discharge planning for safe hospital transitions. Effectively performed, this process supports patient satisfaction, efficient resource utilization, and care integration. This study developed/tested the utility of a predictive early discharge risk assessment with 366 elective orthopedic/cardiovascular surgery patients. Quality improvement cycles were undertaken for the design and to inform analytic plan...
2016: International Journal of Integrated Care
https://www.readbyqxmd.com/read/27609345/the-genome-of-the-largest-bony-fish-ocean-sunfish-mola-mola-provides-insights-into-its-fast-growth-rate
#17
Hailin Pan, Hao Yu, Vydianathan Ravi, Cai Li, Alison P Lee, Michelle M Lian, Boon-Hui Tay, Sydney Brenner, Jian Wang, Huanming Yang, Guojie Zhang, Byrappa Venkatesh
BACKGROUND: The ocean sunfish (Mola mola), which can grow up to a length of 2.7 m and weigh 2.3 tons, is the world's largest bony fish. It has an extremely fast growth rate and its endoskeleton is mainly composed of cartilage. Another unique feature of the sunfish is its lack of a caudal fin, which is replaced by a broad and stiff lobe that results in the characteristic truncated appearance of the fish. RESULTS: To gain insights into the genomic basis of these phenotypic traits, we sequenced the sunfish genome and performed a comparative analysis with other teleost genomes...
2016: GigaScience
https://www.readbyqxmd.com/read/27604134/whole-exome-sequencing-analysis-reveals-trpv3-as-a-risk-factor-for-cardioembolic-stroke
#18
Caty Carrera, Jordi Jiménez-Conde, Sophia Derdak, Kelly Rabionet, Cristofol Vives-Bauzá, Carolina Soriano-Tárrega, Eva Giralt-Steinhauer, Marina Mola-Caminal, Rosa M Diaz-Navarro, Silvia Tur, Elena Muiño, Cristina Gallego-Fabrega, Sergi Beltran, Jaume Roquer, Agustin Ruiz, Oscar Sotolongo-Grau, Jurek Krupinski, Jin-Moo Lee, Carlos Cruchaga, Pilar Delgado, Rainer Malik, Brad B Worrall, Sudha Seshadri, Joan Montaner, Israel Fernández-Cadenas
Genetic studies suggest that hundreds of genes associated with stroke remain unidentified. Exome sequencing proves useful for finding new genes associated with stroke. We aimed to find new genetic risk factors for cardioembolic stroke by analysing exome sequence data using new strategies. For discovery, we analysed 42 cardioembolic stroke cases and controls with extreme phenotypes (cohort 1), and for replication, 32 cardioembolic stroke cases and controls (cohort 2) using the SeqCapExome capture kit. We then analysed the replicated genes in two new cohorts that comprised 834 cardioembolic strokes and controls (cohort 3) and 64,373 cardioembolic strokes and controls (cohort 4)...
November 30, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27601421/body-mass-index-and-psychiatric-disorders-a-mendelian-randomization-study
#19
Fernando Pires Hartwig, Jack Bowden, Christian Loret de Mola, Luciana Tovo-Rodrigues, George Davey Smith, Bernardo Lessa Horta
Obesity is a highly prevalent risk factor for cardiometabolic diseases. Observational studies suggest that obesity is associated with psychiatric traits, but causal inference from such studies has several limitations. We used two-sample Mendelian randomization methods (inverse variance weighting, weighted median and MR-Egger regression) to evaluate the association of body mass index (BMI) with three psychiatric traits using data from the Genetic Investigation of Anthropometric Traits and Psychiatric Genomics consortia...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27596337/genomic-ancestry-and-the-social-pathways-leading-to-major-depression-in-adulthood-the-mediating-effect-of-socioeconomic-position-and-discrimination
#20
Christian Loret de Mola, Fernando Pires Hartwig, Helen Gonçalves, Luciana de Avila Quevedo, Ricardo Pinheiro, Denise Petrucci Gigante, Janaína Vieira Dos Santos Motta, Alexandre C Pereira, Fernando C Barros, Bernardo Lessa Horta
BACKGROUND: Evidence suggests that there is an association between ethnicity/skin color and depression; however, many contextual and individual variables, like sense of discrimination and socioeconomic position (SEP), might influence the direction of this association. We assessed the association between African ancestry and major depression among young adults that have been followed-up since birth in a Southern Brazilian city, and the mediating effect of SEP and discrimination. METHODS: In 1982, all hospital deliveries in Pelotas (Southern Brazil) were identified; liveborns were examined and their mothers interviewed (n = 5914)...
2016: BMC Psychiatry
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