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N Fiorentino, V Ventorino, C Rocco, V Cenvinzo, D Agrelli, L Gioia, I Di Mola, P Adamo, O Pepe, M Fagnano
Phytoremediation is a cost-effective "green technology" that uses plants to improve the soil properties of polluted sites, preventing the dispersion of pollutants and reducing the mobility of potentially toxic elements (PTEs) through their adsorption and accumulation by roots or precipitation within the root zone. Being highly tolerant to pollutants and other abiotic stresses, giant reed (Arundo donax L.) is a suitable biomass crop for phytoremediation of contaminated soils. We report the results of a two-year open-air lysimeter study aimed at assessing the adaptability of giant reed to grow on industrial substrates polluted by Pb and Zn and at testing commercial humic acids from leonardite as improvers of plant performance...
October 6, 2016: Science of the Total Environment
Antonia Di Mola, Elena Gatta, Carmen Petronzi, Aroldo Cupello, Paolo De Caprariis, Mauro Robello, Antonio Massa, Rosanna Filosa
A focused N-substituted 3-(2-piperazin-1-yl-2-oxoethyl)-2-(pyridin-2-yl)iso-indolin-1-ones small library was synthesized for modulation of GABA-A receptor function and compared to Zopiclone for the ability to increase GABA-activated chloride currents. All compounds were tested for their effects on GABA-activated chloride currents in rat cerebellar granule cells by use of the whole-cell patch clamp technique. Electrophysiological studies on cultured cerebellar granule cells revealed 3-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-2-(5-nitropyridin-2-yl)iso-indolin-1-one (Id) as a partial agonist displaying 34% increase of the 10μM GABA evoked peak chloride currents, antagonized by flumazenil...
September 15, 2016: Bioorganic & Medicinal Chemistry Letters
Sandra Motas, Virginia Haurigot, Miguel Garcia, Sara Marcó, Albert Ribera, Carles Roca, Xavier Sánchez, Víctor Sánchez, Maria Molas, Joan Bertolin, Luca Maggioni, Xavier León, Jesús Ruberte, Fatima Bosch
Mucopolysaccharidosis type II (MPSII) is an X-linked lysosomal storage disease characterized by severe neurologic and somatic disease caused by deficiency of iduronate-2-sulfatase (IDS), an enzyme that catabolizes the glycosaminoglycans heparan and dermatan sulphate. Intravenous enzyme replacement therapy (ERT) currently constitutes the only approved therapeutic option for MPSII. However, the inability of recombinant IDS to efficiently cross the blood-brain barrier (BBB) limits ERT efficacy in treating neurological symptoms...
June 16, 2016: JCI Insight
Ehud Even-Or, Alexandra Eden-Walker, Maria Di Mola, Elizabeth McDougall, Tal Schechter, Muhammad Ali, Gordana Svajger, Adam Gassas, Christoph Licht, Joerg Krueger
BACKGROUND: Peripheral stem cell collections can be challenging in the pediatric population and respective experience is limited. Since February 2015 our institution is utilizing the new Spectra Optia (Optia) apheresis device, which has replaced the former COBE Spectra (COBE) device. As a quality initiative we collected and compared collection efficiency (CE2) and other collection variables between the two devices. STUDY DESIGN AND METHODS: In this retrospective study we collected and compared clinical, laboratory, and technical collection data from stem cell collection procedures done with the Optia and COBE devices...
October 3, 2016: Transfusion
Victoria Vaughan Dickson, Christopher S Lee, Karen S Yehle, Ana Mola, Kenneth M Faulkner, Barbara Riegel
Although coronary heart disease (CHD) requires a significant amount of self-care, there are no instruments available to measure self-care in this population. The purpose of this study was to test the psychometric properties of the Self-Care of Coronary Heart Disease Inventory (SC-CHDI). Using the Self-Care of Chronic Illness theory, we developed a 22-item measure of maintenance, management, and confidence appropriate for persons with stable CHD and tested it in a convenience sample of 392 adults (62% male, mean age 61...
September 30, 2016: Research in Nursing & Health
Genene T Mola, Elhadi A A Arbab, Bidini A Taleatu, K Kaviyarasu, Ishaq Ahmad, M Maaza
Vanadium pentoxide V2 O5 thin films were grown at room temperature on ITO coated glass substrates by electrochemical deposition. The resulting films were annealed at 300, 400 and 500°C for 1 h in ambient environment. The effect of heat treatment on the films properties such as surface morphology, crystal structure, optical absorption and photoluminescence were investigated. The x-ray diffraction study showed that the films are well crystallized with temperatures. Strong reflection from plane (400) indicated the film's preferred growth orientation...
September 29, 2016: Journal of Microscopy
J Mallada, N Perez-Carmona, L Berenguer-Ruiz, R Sanchez-Perez, R Martin-Gonzalez, D Sola-Martinez, S Mola, J M Lopez-Arlandis, R Vela-Yebra, L Gabaldon-Torres, E Freire-Alvarez, A Garcia-Escriva, A P Sempere
INTRODUCTION: Post-authorisation studies are important to confirm whether the outcomes of clinical trials are reproduced in usual clinical practice. AIMS: To evaluate the effectiveness and safety of fingolimod in clinical practice in the province of Alicante. PATIENTS AND METHODS: A retrospective multi-centre study was conducted with remitting multiple sclerosis patients treated with fingolimod. Demographic, clinical and pharmacological data were collected...
September 5, 2016: Revista de Neurologia
Pierluigi di Sebastiano, Tommaso Grottola, F Francesco di Mola
Borderline resectable pancreatic cancer is now recognized as a distinct clinical entity. In these cases, neoadjuvant treatment could maximize the potential for an R0 resection and avoid R1/R2 resections. In fact, by analyzing, the current literature is evident that approximately one-third of initially borderline resectable pancreatic tumors may undergo successful resection following neoadjuvant therapy. However, the enormous difficulties in achieving a consensus and the variability in therapeutic algorithms have delayed progress in establishing strong evidence-based practices for diagnosis and treatment...
September 15, 2016: Updates in Surgery
Michael Foerster, Jordi Prat, Valenti Massana, Nahikari Gonzalez, Abel Fontsere, Bernat Molas, Oscar Matilla, Eric Pellegrin, Lucia Aballe
A variety of custom-built sample holders offer users a wide range of non-standard measurements at the ALBA synchrotron PhotoEmission Electron Microscope (PEEM) experimental station. Some of the salient features are: an ultrahigh vacuum (UHV) suitcase compatible with many offline deposition and characterization systems, built-in electromagnets for uni- or biaxial in-plane (IP) and out-of-plane (OOP) fields, as well as the combination of magnetic fields with electric fields or current injection. Electronics providing a synchronized sinusoidal signal for sample excitation enable time-resolved measurements at the 500MHz storage ring RF frequency...
August 30, 2016: Ultramicroscopy
Brenda Ohta, Ana Mola, Peri Rosenfeld, Shauna Ford
BACKGROUND/METHODS: Readmission prevention is a marker of patient care quality and requires comprehensive, early discharge planning for safe hospital transitions. Effectively performed, this process supports patient satisfaction, efficient resource utilization, and care integration. This study developed/tested the utility of a predictive early discharge risk assessment with 366 elective orthopedic/cardiovascular surgery patients. Quality improvement cycles were undertaken for the design and to inform analytic plan...
2016: International Journal of Integrated Care
Hailin Pan, Hao Yu, Vydianathan Ravi, Cai Li, Alison P Lee, Michelle M Lian, Boon-Hui Tay, Sydney Brenner, Jian Wang, Huanming Yang, Guojie Zhang, Byrappa Venkatesh
BACKGROUND: The ocean sunfish (Mola mola), which can grow up to a length of 2.7 m and weigh 2.3 tons, is the world's largest bony fish. It has an extremely fast growth rate and its endoskeleton is mainly composed of cartilage. Another unique feature of the sunfish is its lack of a caudal fin, which is replaced by a broad and stiff lobe that results in the characteristic truncated appearance of the fish. RESULTS: To gain insights into the genomic basis of these phenotypic traits, we sequenced the sunfish genome and performed a comparative analysis with other teleost genomes...
2016: GigaScience
Caty Carrera, Jordi Jiménez-Conde, Sophia Derdak, Kelly Rabionet, Cristofol Vives-Bauzá, Carolina Soriano-Tárrega, Eva Giralt-Steinhauer, Marina Mola, Rosa M Diaz-Navarro, Silvia Tur, Elena Muiño, Cristina Gallego-Fabrega, Sergi Beltran, Jaume Roquer, Agustin Ruiz, Oscar Sotolongo-Grau, Jurek Krupinski, Jin-Moo Lee, Carlos Cruchaga, Pilar Delgado, Rainer Malik, Brad B Worrall, Sudha Seshadri, Joan Montaner, Israel Fernández-Cadenas
Genetic studies suggest that hundreds of genes associated with stroke remain unidentified. Exome sequencing proves useful for finding new genes associated with stroke. We aimed to find new genetic risk factors for cardioembolic stroke by analysing exome sequence data using new strategies. For discovery, we analysed 42 cardioembolic stroke cases and controls with extreme phenotypes (cohort 1), and for replication, 32 cardioembolic stroke cases and controls (cohort 2) using the SeqCapExome capture kit. We then analysed the replicated genes in two new cohorts that comprised 834 cardioembolic strokes and controls (cohort 3) and 64,373 cardioembolic strokes and controls (cohort 4)...
September 8, 2016: Thrombosis and Haemostasis
Fernando Pires Hartwig, Jack Bowden, Christian Loret de Mola, Luciana Tovo-Rodrigues, George Davey Smith, Bernardo Lessa Horta
Obesity is a highly prevalent risk factor for cardiometabolic diseases. Observational studies suggest that obesity is associated with psychiatric traits, but causal inference from such studies has several limitations. We used two-sample Mendelian randomization methods (inverse variance weighting, weighted median and MR-Egger regression) to evaluate the association of body mass index (BMI) with three psychiatric traits using data from the Genetic Investigation of Anthropometric Traits and Psychiatric Genomics consortia...
2016: Scientific Reports
Christian Loret de Mola, Fernando Pires Hartwig, Helen Gonçalves, Luciana de Avila Quevedo, Ricardo Pinheiro, Denise Petrucci Gigante, Janaína Vieira Dos Santos Motta, Alexandre C Pereira, Fernando C Barros, Bernardo Lessa Horta
BACKGROUND: Evidence suggests that there is an association between ethnicity/skin color and depression; however, many contextual and individual variables, like sense of discrimination and socioeconomic position (SEP), might influence the direction of this association. We assessed the association between African ancestry and major depression among young adults that have been followed-up since birth in a Southern Brazilian city, and the mediating effect of SEP and discrimination. METHODS: In 1982, all hospital deliveries in Pelotas (Southern Brazil) were identified; liveborns were examined and their mothers interviewed (n = 5914)...
2016: BMC Psychiatry
Carolina Soriano-Tárraga, Eva Giralt-Steinhauer, Marina Mola-Caminal, Rosa M Vivanco-Hidalgo, Angel Ois, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Sergi Sayols-Baixeras, Roberto Elosua, Jaume Roquer, Jordi Jiménez-Conde
Ischemic stroke is associated with aging. It is possible to predict chronological age by measuring age-related changes in DNA methylation from multiple CpG sites across the genome, known as biological age. The difference between biological age and actual chronological age would indicate an individual's level of aging. Our aim was to determine the biological age of ischemic stroke patients and compare their aging with controls of the same chronological age. A total of 123 individuals, 41 controls and 82 patients with ischemic stroke were paired by chronological age, ranging from 39 to 82 years...
August 25, 2016: Aging
Olalla Díaz-Yáñez, Blas Mola-Yudego, Rune Eriksen, José Ramón González-Olabarria
The re-measurement of permanent forest inventories offers a unique opportunity to assess the occurrence and impact of forest disturbances. The present study aims at exploring the main forest damages in Norway based on the extensive data of several consecutive national forest inventories during the period 1995-2014. Five of the most common disturbance agents in Norway are selected for analysis: wind, snow, browsing, fungus and insect damage. The analyses focuses on the frequency and variation along time, the average damage at stand level and the spatial patterns of damage occurrence, resulting in a characterization of the damage produced by disturbances in Norway...
2016: PloS One
Margaret J Trost, Kira Molas-Torreblanca, Carol Man, Ernesto Casillas, Hoda Sapir, Sheree M Schrager
BACKGROUND: Postpartum depression is common and adversely affects children of afflicted mothers; postpartum depression recognition and treatment may improve outcomes. Hospitalization represents a potential health encounter for expanding screening and intervention. OBJECTIVE: We aimed to assess for postpartum depression at infant hospitalization and examine postpartum depression risk factors in this population. DESIGN, SETTING, AND PARTICIPANTS: We conducted a prospective observational study of 310 English- or Spanish-speaking women with an infant aged 2 weeks to 1 year admitted to a pediatric hospitalist service at a large urban freestanding children's hospital...
August 16, 2016: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
Patrícia J Peter, Christian L de Mola, Mariana B de Matos, Fábio M Coelho, Karen A Pinheiro, Ricardo A da Silva, Rochele D Castelli, Ricardo T Pinheiro, Luciana A Quevedo
Objective: To evaluate the association between perceived social support and anxiety disorders in pregnant adolescents. Methods: We conducted a cross-sectional study with a sample of 871 pregnant women aged 10 to 19 years who received prenatal care in the national public health care system in the urban area of Pelotas, state of Rio Grande do Sul, southern Brazil. We assessed perceived social support and anxiety disorders using the Medical Outcomes Study Social Support Survey and the Mini International Neuropsychiatric Interview...
August 4, 2016: Revista Brasileira de Psiquiatria
Tamara Posati, Assunta Pistone, Emanuela Saracino, Francesco Formaggio, Maria Grazia Mola, Elisabetta Troni, Anna Sagnella, Morena Nocchetti, Marianna Barbalinardo, Francesco Valle, Simone Bonetti, Marco Caprini, Grazia Paola Nicchia, Roberto Zamboni, Michele Muccini, Valentina Benfenati
Potassium channels and aquaporins expressed by astrocytes are key players in the maintenance of cerebral homeostasis and in brain pathophysiologies. One major challenge in the study of astrocyte membrane channels in vitro, is that their expression pattern does not resemble the one observed in vivo. Nanostructured interfaces represent a significant resource to control the cellular behaviour and functionalities at micro and nanoscale as well as to generate novel and more reliable models to study astrocytes in vitro...
2016: Scientific Reports
Lara L Sousa, Francisco López-Castejón, Javier Gilabert, Paulo Relvas, Ana Couto, Nuno Queiroz, Renato Caldas, Paulo Sousa Dias, Hugo Dias, Margarida Faria, Filipe Ferreira, António Sérgio Ferreira, João Fortuna, Ricardo Joel Gomes, Bruno Loureiro, Ricardo Martins, Luis Madureira, Jorge Neiva, Marina Oliveira, João Pereira, José Pinto, Frederic Py, Hugo Queirós, Daniel Silva, P B Sujit, Artur Zolich, Tor Arne Johansen, João Borges de Sousa, Kanna Rajan
Over the last decade, ocean sunfish movements have been monitored worldwide using various satellite tracking methods. This study reports the near-real time monitoring of fine-scale (< 10 m) behaviour of sunfish. The study was conducted in southern Portugal in May 2014 and involved satellite tags and underwater and surface robotic vehicles to measure both the movements and the contextual environment of the fish. A total of four individuals were tracked using custom-made GPS satellite tags providing geolocation estimates of fine-scale resolution...
2016: PloS One
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