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https://www.readbyqxmd.com/read/29315408/birth-order-and-number-of-siblings-and-their-association-with-overweight-and-obesity-a-systematic-review-and-meta-analysis
#1
Fernanda Oliveira Meller, Christian Loret de Mola, Maria Cecília Formoso Assunção, Antônio Augusto Schäfer, Darren Lawrence Dahly, Fernando Celso Barros
Context: The effect of both birth order and number of siblings on overweight and/or obesity has not been determined. Birth order and sibsize have been mathematically coupled to overweight and/or obesity, but thus far their respective effects have been estimated separately. Objective: The aim of this systematic review was to evaluate the effects of both birth order and number of siblings on the risk of overweight/obesity. Data Sources: The electronic databases MEDLINE, Social Science, SocINDEX, PsycINFO, CINAHL Plus, and Academic Search Complete were searched systematically...
January 5, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29288183/performance-of-syndromic-management-for-the-detection-and-treatment-of-genital-chlamydia-trachomatis-neisseria-gonorrhoeae-and-trichomonas-vaginalis-among-women-attending-antenatal-well-woman-and-sexual-health-clinics-in-papua-new-guinea-a-cross-sectional-study
#2
Lisa M Vallely, Pamela Toliman, Claire Ryan, Glennis Rai, Johanna Wapling, Josephine Gabuzzi, Joyce Allen, Christine Opa, Gloria Munnull, Petronia Kaima, Benny Kombuk, Antonia Kumbia, Zure Kombati, Greg Law, Angela Kelly-Hanku, Handan Wand, Peter M Siba, Glen D L Mola, John M Kaldor, Andrew J Vallely
OBJECTIVE: Papua New Guinea (PNG) has among the highest estimated prevalences of genital Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) of any country in the Asia-Pacific region. Diagnosis and treatment of these infections have relied on the WHO-endorsed syndromic management strategy that uses clinical presentation without laboratory confirmation to make treatment decisions. We evaluated the performance of this strategy in clinical settings in PNG...
December 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/29285254/microrna-co-expression-networks-exhibit-increased-complexity-in-pancreatic-ductal-compared-to-vater-s-papilla-adenocarcinoma
#3
Tommaso Mazza, Massimiliano Copetti, Daniele Capocefalo, Caterina Fusilli, Tommaso Biagini, Massimo Carella, Antonio De Bonis, Nicola Mastrodonato, Ada Piepoli, Valerio Pazienza, Evaristo Maiello, Fabio Francesco di Mola, Pierluigi di Sebastiano, Angelo Andriulli, Francesca Tavano
MiRNA expression abnormalities in adenocarcinoma arising from pancreatic ductal system (PDAC) and Vater's papilla (PVAC) could be associated with distinctive pathologic features and clinical cancer behaviours. Our previous miRNA expression profiling data on PDAC (n=9) and PVAC (n=4) were revaluated to define differences/similarities in miRNA expression patterns. Afterwards, in order to uncover target genes and core signalling pathways regulated by specific miRNAs in these two tumour entities, miRNA interaction networks were wired for each tumour entity, and experimentally validated target genes underwent pathways enrichment analysis...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29197877/functional-characterization-of-a-novel-truncating-mutation-in-lamin-a-c-gene-in-a-family-with-a-severe-cardiomyopathy-with-conduction-defects
#4
Andrea Gerbino, Irene Bottillo, Serena Milano, Martina Lipari, Roberta De Zio, Silvia Morlino, Maria Grazia Mola, Giuseppe Procino, Federica Re, Elisabetta Zachara, Paola Grammatico, Maria Svelto, Monica Carmosino
BACKGROUND/AIMS: Truncating LMNA gene mutations occur in many inherited cardiomyopathy cases, but the molecular mechanisms involved in the disease they cause have not yet been systematically investigated. Here, we studied a novel frameshift LMNA variant (p.D243Gfs*4) identified in three members of an Italian family co-segregating with a severe form of cardiomyopathy with conduction defects. METHODS: HEK293 cells and HL-1 cardiomyocytes were transiently transfected with either Lamin A or D243Gfs*4 tagged with GFP (or mCherry)...
December 4, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29179644/frequency-and-severity-of-potential-drug-interactions-in-a-cohort-of-hiv-infected-patients-identified-through-a-multidisciplinary-team
#5
E Molas, S Luque, A Retamero, D Echeverría-Esnal, A Guelar, M Montero, R Guerri, L Sorli, E Lerma, J Villar, H Knobel
OBJECTIVES: Interactions between antiretroviral treatment (ART) and comedications are a concern in HIV-infected patients. This study aimed to determine the frequency and severity of potential drug-drug interactions (PDDIs) with ART in our setting. METHODS: Observational study by a multidisciplinary team in 1259 consecutive HIV patients (March 2015-September 2016). Data on demographics, toxic habits, comorbidities, and current ART were collected. A structured questionnaire recorded concomitant medications (including occasional and over-the-counter drugs)...
November 28, 2017: HIV Clinical Trials
https://www.readbyqxmd.com/read/29169695/immunohistochemical-analysis-of-the-distribution-of-molecules-involved-in-ionic-and-ph-regulation-in-the-lancelet-branchiostoma-floridae-hubbs-1922
#6
Ivan Cuoghi, Clara Lazzaretti, Mauro Mandrioli, Lucrezia Mola, Aurora Pederzoli
The aim of present work is to analyse the distribution of carbonic anhydrase II (CAII), cystic fibrosis transmembrane regulator (CFTR), vacuolar-type H(+)-ATPase (V-H(+)-ATPase), Na(+)/K(+) ATPase, Na(+)/H(+) exchanger (NHE) and SLC26A6 (solute carrier family 26, member 6), also known as pendrin protein, in the lancelet Branchiostoma floridae in order to go in depth in the evolution of osmoregulation and pH regulation in Chordates. In view of their phylogenetic position, lancelets may indeed provide a critical point of reference for studies on osmoregulation evolution in Chordates...
November 20, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/29150599/publisher-correction-interlayer-excitons-in-a-bulk-van-der-waals-semiconductor
#7
Ashish Arora, Matthias Drüppel, Robert Schmidt, Thorsten Deilmann, Robert Schneider, Maciej R Molas, Philipp Marauhn, Steffen Michaelis de Vasconcellos, Marek Potemski, Michael Rohlfing, Rudolf Bratschitsch
A correction to this article has been published and is linked from the HTML version of this article.
November 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29095016/hospital-malnutrition-screening-at-admission-malnutrition-increases-mortality-and-length-of-stay
#8
Elisabet Leiva Badosa, Maria Badia Tahull, Núria Virgili Casas, Gema Elguezabal Sangrador, Concepción Faz Méndez, Ignacio Herrero Meseguer, Àngels Izquierdo González, Rafael López Urdiales, Francisco Javier Oca Burguete, María Tubau Molas, Concepció Vilarasau Farré, Josep Manel Llop Talaveron
INTRODUCTION: Malnutrition is common in patients admitted to hospital and is associated with morbidity and mortality. We conducted a study to assess the prevalence of nutritional risk, risk factors associated and its consequences in a third-level hospital. METHODS: This is a prospective nutritional screening study of hospitalized patients evaluated within the first 72 hours of admission, by Malnutrition Universal Screening Tool (MUST) and Short Nutritional Assessment Questionnaire (SNAQ) screening tests...
July 28, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29052814/responsiveness-and-minimal-important-change-of-the-neckpix%C3%A2-in-subjects-with-chronic-neck-pain-undergoing-rehabilitation
#9
Marco Monticone, Luca Frigau, Howard Vernon, Barbara Rocca, Francesco Mola
PURPOSE: The NeckPix© is a simple and rapid means of measuring the beliefs of subjects with chronic neck pain concerning pain-related fears of a specific set of activities of daily living. The original version showed satisfactory psychometric properties. This observational study is aimed at evaluating its responsiveness and minimal important changes (MICs) in subjects with chronic neck pain. METHODS: At the beginning, at the end of an 8-week rehabilitation programme as well as at the one-year follow-up, 153 subjects completed the NeckPix©...
October 20, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29044946/aquaporin-1-inhibition-reduces-metastatic-formation-in-a-mouse-model-of-melanoma
#10
Laura Simone, Concetta Domenica Gargano, Francesco Pisani, Antonio Cibelli, Maria Grazia Mola, Antonio Frigeri, Maria Svelto, Grazia Paola Nicchia
Aquaporin-1 (AQP1) is a proangiogenic water channel protein promoting endothelial cell migration. We previously reported that AQP1 silencing by RNA interference reduces angiogenesis-dependent primary tumour growth in a mouse model of melanoma. In this study, we tested the hypothesis that AQP1 inhibition also affects animal survival and lung nodule formation. Melanoma was induced by injecting B16F10 cells into the back of C57BL6J mice. Intratumoural injection of AQP1 siRNA and CTRL siRNA was performed 10 days after tumour cell implantation...
October 17, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28992976/a-mixed-methods-evaluation-of-the-feasibility-and-acceptability-of-an-adapted-cardiac-rehabilitation-program-for-home-care-patients
#11
Jodi L Feinberg, David Russell, Ana Mola, Melissa Trachtenberg, Irene Bick, Terri H Lipman, Kathryn H Bowles
Home care clinicians have an opportunity to improve care for post-hospitalization patients with cardiovascular disease. This mixed methods study examined the feasibility and acceptability of an adapted cardiac rehabilitation (CR) program for the home care setting. Surveys measuring patient self-care and knowledge were administered to patients (n = 46) at baseline and at 30-day follow-up. Semi-structured interviews were conducted with patients (n = 28) and home care clinicians (n = 11) at completion of the program...
October 6, 2017: Geriatric Nursing
https://www.readbyqxmd.com/read/28977577/early-menarche-and-blood-pressure-in-adulthood-systematic-review-and-meta-analysis
#12
S Bubach, C Loret De Mola, R Hardy, J Dreyfus, A C Santos, B L Horta
Background: It has been reported that early menarche is associated with high blood pressure and hypertension. However, some studies have failed to observe such association. We carried out a systematic review and meta-analysis on the association of early menarche with hypertension and high blood pressure in adulthood. Methods: PUBMED, SciELO, Scopus and LILACS databases were searched. Studies that evaluated the association of early menarche with hypertension or high blood pressure, among women aged 20 years or more were included...
September 11, 2017: Journal of Public Health
https://www.readbyqxmd.com/read/28974845/challenges-in-the-routine-praxis-diagnosis-of-hydatidiform-mole-a-tertiary-health-center-experience
#13
Melisa Lelic, Zlatan Fatusic, Ermina Iljazovic, Suada Ramic, Sergije Markovic, Selma Alicelebic
INTRODUCTION: Hydatidiform moles (HM), presenting as complete (CHM) and partial (PHM) form, are rare pregnancy disorder. Diagnosis is based on clinical presentation, ultrasound imaging findings and pathological examination of products of conception. Protein p57, encoded by CKDN1C gene, is paternally imprinted and maternally expressed gene and provides quick insight in genetic basis of HM and allows distinction of CHM from all other conceptions. compare the preevacuational and pathohistological diagnosis with outcome of p57 immunostaining...
August 2017: Medical Archives
https://www.readbyqxmd.com/read/28974730/maternal-smoking-in-pregnancy-and-offspring-depression-a-cross-cohort-and-negative-control-study
#14
Amy E Taylor, David Carslake, Christian Loret de Mola, Mina Rydell, Tom I L Nilsen, Johan H Bjørngaard, Bernardo Lessa Horta, Rebecca Pearson, Dheeraj Rai, Maria Rosaria Galanti, Fernando C Barros, Pål R Romundstad, George Davey Smith, Marcus R Munafò
Previous reports suggest that offspring of mothers who smoke during pregnancy have greater risk of developing depression. However, it is unclear whether this is due to intrauterine effects. Using data from the Avon Longitudinal Study of Parents and Children (ALSPAC) from the UK (N = 2,869), the Nord-Trøndelag health study (HUNT) from Norway (N = 15,493), the Pelotas 1982 Birth Cohort Study from Brazil (N = 2,626), and the Swedish Sibling Health Cohort (N = 258 sibling pairs), we compared associations of maternal smoking during pregnancy and mother's partner's smoking during pregnancy with offspring depression and performed a discordant sibling analysis...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28960552/programmes-for-the-prevention-of-parent-to-child-transmission-of-hiv-in-papua-new-guinea-health-system-challenges-and-opportunities
#15
Anna Tynan, Lisa Vallely, Martha Kupul, Ruthy Neo, Voletta Fiya, Heather Worth, Grace Kariwiga, Glen D L Mola, John Kaldor, Angela Kelly-Hanku
BACKGROUND: Prevention of parent-to-child transmission (PPTCT) of HIV is a highly complex package of interventions, which spans services in both maternal and child health programmes. In Papua New Guinea (PNG), a commitment to ensure that all pregnant women and their partners have access to the full range of PPTCT interventions exists; however, efforts to increase access and utilisation of PPTCT remain far from optimal. The aim of this paper is to examine health care worker (HCW) perception of health system factors impacting on the performance of PPTCT programmes...
September 27, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/28956439/formal-total-synthesis-of-amphidinolide-e
#16
Lluís Bosch, Laura Mola, Elena Petit, Mar Saladrigas, Jorge Esteban, Anna M Costa, Jaume Vilarrasa
A formal total synthesis of the cytotoxic macrolide amphidinolide E is reported. The strategic steps are three Julia-Kocienski reactions (J-K), for the formation of the C5-C6, C9-C10, and C17-C18 double bonds, a Suzuki-Molander C21-C22 bond formation reaction, and a Kita-Trost macrolactonization. The "instability" of the two dienic systems and of the stereocenter at C2 (allylic methine, α to the carboxy group) and the protecting groups at C17-OH and C18-OH have posed difficult challenges. Each Julia-Kocienski olefination has been systematically optimized to provide the highest possible E/Z ratios...
October 6, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28940930/potential-role-of-the-methylation-of-vegf-gene-promoter-in-response-to-hypoxia-in-oxygen-induced-retinopathy-beneficial-effect-of-the-absence-of-aqp4
#17
Francesco Pisani, Maurizio Cammalleri, Massimo Dal Monte, Filippo Locri, Maria Grazia Mola, Grazia Paola Nicchia, Antonio Frigeri, Paola Bagnoli, Maria Svelto
Hypoxia-dependent accumulation of vascular endothelial growth factor (VEGF) plays a major role in retinal diseases characterized by neovessel formation. In this study, we investigated whether the glial water channel Aquaporin-4 (AQP4) is involved in the hypoxia-dependent VEGF upregulation in the retina of a mouse model of oxygen-induced retinopathy (OIR). The expression levels of VEGF, the hypoxia-inducible factor-1α (HIF-1α) and the inducible form of nitric oxide synthase (iNOS), the production of nitric oxide (NO), the methylation status of the HIF-1 binding site (HBS) in the VEGF gene promoter, the binding of HIF-1α to the HBS, the retinal vascularization and function have been determined in the retina of wild-type (WT) and AQP4 knock out (KO) mice under hypoxic (OIR) or normoxic conditions...
September 22, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28935879/interlayer-excitons-in-a-bulk-van-der-waals-semiconductor
#18
Ashish Arora, Matthias Drüppel, Robert Schmidt, Thorsten Deilmann, Robert Schneider, Maciej R Molas, Philipp Marauhn, Steffen Michaelis de Vasconcellos, Marek Potemski, Michael Rohlfing, Rudolf Bratschitsch
Bound electron-hole pairs called excitons govern the electronic and optical response of many organic and inorganic semiconductors. Excitons with spatially displaced wave functions of electrons and holes (interlayer excitons) are important for Bose-Einstein condensation, superfluidity, dissipationless current flow, and the light-induced exciton spin Hall effect. Here we report on the discovery of interlayer excitons in a bulk van der Waals semiconductor. They form due to strong localization and spin-valley coupling of charge carriers...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28906578/ultra-early-hematoma-growth-in-antithrombotic-pretreated-patients-with-intracerebral-hemorrhage
#19
J Roquer, R M Vivanco-Hidalgo, J Capellades, A Ois, E Cuadrado-Godia, E Giralt-Steinhauer, C Soriano-Tárraga, M Mola-Caminal, M Serra-Martínez, C Avellaneda-Gómez, J Jiménez-Conde, A Rodríguez-Campello
BACKGROUND AND PURPOSE: Patients with acute intracerebral hemorrhage (ICH) pretreated with antithrombotic drugs may have increased early hematoma growth, which would increase mortality risk. The effect of antiplatelet (AP) and vitamin K antagonist (VKA) pretreatment on ultra-early hematoma growth (uHG) and its relationship with mortality in patients with acute supratentorial ICH was analyzed. METHODS: This is an observational retrospective study of a prospective register of 197 ICH patients with first computed tomography (CT) scan taken <6 h from ICH symptom onset...
September 14, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28905097/color-doppler-and-spectral-doppler-ultrasound-detection-of-active-sacroiliitis-in-spondyloarthritis-compared-to-physical-examination-as-gold-standard
#20
Concepción Castillo-Gallego, Eugenio De Miguel, Miriam García-Arias, Chamaida Plasencia, Leticia Lojo-Oliveira, Emilio Martín-Mola
Sacroiliac joint (SIJ) involvement is a distinctive feature of spondyloarthritis (SpA). The main objective of this study was to assess the validity of color Doppler ultrasound (CDUS) in SIJ. This was a cross-sectional, blinded, case-control study of 108 cases divided into three groups: (a) 53 SpA patients with inflammatory back pain (IBP); (b) 28 SpA patients with no IBP; and (c) 27 healthy mechanical lumbar pain subjects. Physical examinations of the SIJs were assessed as positive or negative in each SIJ and were used as the gold standard...
December 2017: Rheumatology International
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