Richard J Burman, Tara Diviney, Alexandru Călin, Gemma Gothard, Jean-Sébastien M Jouhanneau, James F A Poulet, Arjune Sen, Colin J Akerman
The reversal potential refers to the membrane potential at which the net current flow through a channel reverses direction. The reversal potential is determined by transmembrane ion gradients and, in turn, determines how the channel's activity will affect the membrane potential. Traditional investigation into the reversal potential of inhibitory ligand-gated ion channels (EInh ) has relied upon the activation of endogenous receptors, such as the GABA-A receptor (GABAA R). There are, however, challenges associated with activating endogenous receptors, including agonist delivery, isolating channel responses, and the effects of receptor saturation and desensitization...
April 11, 2024: Journal of Neuroscience