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https://www.readbyqxmd.com/read/29931092/japan-united-states-of-america-harmonized-assessment-by-randomized-multicentre-study-of-orbusneich-s-combo-stent-japan-usa-harmonee-study-primary-results-of-the-pivotal-registration-study-of-combined-endothelial-progenitor-cell-capture-and-drug-eluting-stent
#1
Shigeru Saito, Mitchell W Krucoff, Shigeru Nakamura, Roxana Mehran, Akiko Maehara, Hussein R Al-Khalidi, Stephen M Rowland, Gudaye Tasissa, Debbie Morrell, Diane Joseph, Yumiko Okaniwa, Yoshisato Shibata, Barry D Bertolet, Mark D Rothenberg, Philippe Généreux, Hiram Bezerra, David F Kong
Aims: Harmonized Assessment by Randomized Multicentre Study of OrbusNEich's Combo StEnt (HARMONEE) (NCT02073565) was a randomized pivotal registration trial of the Combo stent, which combined sirolimus and an abluminal bioabsorbable polymer with a novel endoluminal anti-CD34+ antibody coating designed to capture endothelial progenitor cells (EPC) and promote percutaneous coronary intervention (PCI) site healing. Methods and results: Clinically stabilized PCI subjects were randomized 1:1 to receive Combo or everolimus-eluting stents (EES)...
June 21, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29930992/imaging-the-deep-choroidal-vasculature-using-spectral-domain-and-swept-source-optical-coherence-tomography-angiography
#2
J Daniel Diaz, Jay C Wang, Patrick Oellers, Inês Lains, Lucia Sobrin, Deeba Husain, Joan W Miller, Demetrios G Vavvas, John B Miller
Purpose: To evaluate the deeper choroidal vasculature in eyes with various ocular disorders using spectral domain (SD) optical coherence tomography angiography (OCTA) and swept source (SS) OCTA. Methods: Patients underwent OCTA imaging with either SD-OCTA (Zeiss Cirrus Angioplex or Optovue AngioVue) or SS-OCTA (Topcon Triton). Retinal pigment epithelium (RPE) integrity, structural visualization of deep choroidal vessels on en face imaging, and OCTA of deep choroidal blood flow signal were analyzed...
May 2018: Journal of Vitreoretinal Diseases
https://www.readbyqxmd.com/read/29927796/improved-detection-and-diagnosis-of-polypoidal-choroidal-vasculopathy-using-a-combination-of-optical-coherence-tomography-and-optical-coherence-tomography-angiography
#3
Chui Ming Gemmy Cheung, Yasuo Yanagi, Masahiro Akiba, Anna Tan, Ranjana Mathur, Choi Mun Chan, Ian Yeo, Tien Y Wong
PURPOSE: To assess the ability of optical coherence tomography (OCT) alone and in combination with OCT angiography (OCTA) to differentiate polypoidal choroidal vasculopathy (PCV) from neovascular age-related macular degeneration, as compared to fluorescein angiography and indocyanine green angiography. METHODS: This is a cross-sectional study. All participants had a standardized history, clinical examination including measurement of best-corrected visual acuity, slit-lamp biomicroscopy, and indirect fundus examination, and underwent standardized imaging (color photography, fluorescein and indocyanine green angiography, OCT, and OCTA) after predefined protocols...
June 20, 2018: Retina
https://www.readbyqxmd.com/read/29927465/morphological-implications-of-vascular-structures-not-visualized-on-optical-coherence-tomography-angiography-in-retinal-vein-occlusion
#4
Michael J Heiferman, Emma J Griebenow, Manjot K Gill, Amani A Fawzi
BACKGROUND AND OBJECTIVE: Advanced retinal imaging can improve understanding of retinal vein occlusion (RVO) pathology. The authors aimed to characterize the vascular pathology of RVO on en face optical coherence tomography (OCT) and OCT angiography (OCTA). PATIENT AND METHODS: This was a cross-sectional study including 17 eyes with RVO. The authors identified discordance between vasculature on en face OCT and flow on OCTA, which was correlated with structural findings at the corresponding location on OCT B-scans...
June 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29927269/large-continuous-perspective-change-with-noncoplanar-points-enables-accurate-slant-perception
#5
Xiaoye Michael Wang, Mats Lind, Geoffrey P Bingham
Perceived slant has often been characterized as a component of 3D shape perception for polyhedral objects. Like 3D shape, slant is often perceived inaccurately. Lind, Lee, Mazanowski, Kountouriotis, and Bingham (2014) found that 3D shape was perceived accurately with perspective changes ≥ 45°. We now similarly tested perception of 3D slant. To account for their results, Lind et al. (2014) developed a bootstrap model based on the assumption that optical information yields perception of 3D relief structure then used with large perspective changes to bootstrap to perception of 3D Euclidean structure...
June 21, 2018: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/29925927/distinct-retinal-capillary-plexuses-in-normal-eyes-as-observed-in-optical-coherence-tomography-angiography-axial-profile-analysis
#6
Takao Hirano, Karntida Chanwimol, Julian Weichsel, Tudor Tepelus, Srinivas Sadda
Optical coherence tomography angiography (OCTA) allows the retinal microvasculature to be visualized at various retinal depths. Previous studies introduced OCTA axial profile analysis and showed regional variations in the number and location of axially distinct vascular retinal plexuses. OCTA acquisition and processing approaches, however, vary in terms of their resulting transverse and axial resolutions, and especially the latter could potentially influence the profile analysis results. Our study imaged normal eyes using the Spectralis OCT2 with a full-spectrum, probabilistic OCTA algorithm, that, in marked contrast to split-spectrum approaches, preserves the original high OCT axial resolution also within the resulting OCTA signal...
June 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29924197/optical-coherence-tomography-oct-angiography-of-central-retinal-artery-occlusion-in-the-patent-cilioretinal-artery-a-case-report
#7
Luis Filipe Nakayama, Vinicius Campos Bergamo, Leticia Sant'ana Cardoso Silva, Nilva Simeren Bueno Moraes
Here we report the case of a 78-year-old male patient with a 2-day history of low visual acuity and fundus and who was diagnosed with central retinal artery occlusion. In addition, the patient had an allergy to fluorescein. A fundus examination of the left eye found a pink optic disc with blurred margins, diffuse pallor in the retina with arterial attenuation, and a normal band of the retinal area in the macular region. Optical coherence tomography revealed increased thickness of the inner retina. Optical coherence tomography angiography (OCT-A) revealed a decreased flow signal in the superficial layers, with reduced flow signal in the choriocapillaris...
June 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29923371/laser-safety-in-fiber-optic-monitoring-of-spinal-cord-hemodynamics-a-preclinical-evaluation
#8
David R Busch, James Davis, Angela Kogler, Robert M Galler, Ashwin B Parthasarathy, Arjun G Yodh, Thomas F Floyd
The prevention and treatment of spinal cord injury are focused upon the maintenance of spinal cord blood flow, yet no technology exists to monitor spinal cord ischemia. We recently demonstrated continuous monitoring of spinal cord ischemia with diffuse correlation and optical spectroscopies using an optical probe. Prior to clinical translation of this technology, it is critically important to demonstrate the safety profile of spinal cord exposure to the required light. To our knowledge, this is the first report of in situ safety testing of such a monitor...
June 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29921908/influence-of-growth-media-components-on-the-antibacterial-effect-of-silver-ions-on-bacillus-subtilis-in-a-liquid-growth-medium
#9
Ilse De Leersnyder, Leen De Gelder, Isabel Van Driessche, Pieter Vermeir
Numerous studies have investigated the antibacterial effect of both silver ions and silver nanomaterials on a large diversity of environmentally and clinically relevant bacteria. However, contradictory results are reported in which inhibition concentrations were varying by a 10-fold. This study investigated whether this variance in results could be attributed to the difference in experimental conditions, especially the microbial growth medium. B. subtilis was exposed to 500 µg L-1 Ag+ in liquid growth media with different concentrations of some commonly used media components: tryptone, yeast extract, Cl- , and S2- ...
June 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29920959/label-free-volumetric-imaging-of-conjunctival-collecting-lymphatics-ex-vivo-by-optical-coherence-tomography-lymphangiography
#10
Peijun Gong, Dao-Yi Yu, Qiang Wang, Paula Yu, Karol Karnowski, Morgan Heisler, Ashley Francke, Dong An, Marinko V Sarunic, David D Sampson
We employ optical coherence tomography (OCT) and optical coherence microscopy (OCM) to study conjunctival lymphatics in porcine eyes ex vivo. This study is a precursor to the development of in vivo imaging of the collecting lymphatics for potentially guiding and monitoring glaucoma filtration surgery. OCT scans at 1300 nm and higher-resolution OCM scans at 785 nm reveal the lymphatic vessels via their optical transparency. Equivalent signal characteristics are also observed from blood vessels largely free of blood (and devoid of flow) in the ex vivo conjunctiva...
June 19, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29920060/semiconductor-nanoplatelets-a-new-class-of-ultrabright-fluorescent-probes-for-cytometric-and-imaging-applications
#11
Djamila Kechkeche, Edgar Cao, Chloé Grazon, Filippo Caschera, Vincent Noireaux, Marie-Laurence Baron-Niel, Benoit Dubertret
Fluorescent semiconductor nanoplatelets (NPLs) are a new generation of fluorescent probes. NPLs are colloidal two-dimensional materials that exhibit several unique optical properties, including high brightness, photostability and extinction coefficients as well as broad excitation and narrow emission spectra from the visible to the near infrared spectrum. All these exceptional fluorescence properties make NPLs interesting nanomaterials for biological applications. However, NPLs are synthesized in organic solvents and coated with hydrophobic ligands that render them insoluble in water...
June 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29916716/real-time-monitoring-of-azo-dye-interfacial-adsorption-at-silica-water-interface-by-total-internal-reflection-induced-surface-evanescent-wave
#12
Yan Xiong, Qing Wang, Ming Duan, Jun Tan, Shenwen Fang, Jiayi Wu
An interface research method based on total internal reflection induced evanescent wave (TIR-EW) is developed to monitor the adsorption behavior of azo dye at the silica-water interface. The monitoring system is constructed by employing silica optical fiber (SOF) as both charged substrate for dye adsorption and light transmission waveguide for evanescent wave production. According to the change of evanescent wave intensity and followed by Beer's law, the methylene blue (MB) adsorption behavior can be real-time monitored at the silica-water interface...
June 19, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29915934/novel-capsaicin-induced-parameters-of-microcirculation-in-migraine-patients-revealed-by-imaging-photoplethysmography
#13
Alexei A Kamshilin, Maxim A Volynsky, Olga Khayrutdinova, Dilyara Nurkhametova, Laura Babayan, Alexander V Amelin, Oleg V Mamontov, Rashid Giniatullin
BACKGROUND: The non-invasive biomarkers of migraine can help to develop the personalized medication of this disorder. In testing of the antimigraine drugs the capsaicin-induced skin redness with activated TRPV1 receptors in sensory neurons associated with the release of the migraine mediator CGRP has already been widely used. METHODS: Fourteen migraine patients (mean age 34.6 ± 10.2 years) and 14 healthy volunteers (mean age 29.9 ± 9.7 years) participated in the experiment...
June 18, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29915367/dispersion-mapping-as-a-simple-postprocessing-step-for-fourier-domain-optical-coherence-tomography-data
#14
Sylwia M Kolenderska, Bastian Bräuer, Frédérique Vanholsbeeck
Optical Coherence Tomography (OCT) was originally conceived as a volumetric imaging method. Quickly, OCT images went beyond structural data and started to provide functional information about an object enabling for example visualization of blood flow or tissue elasticity. Minimal or no need for system alterations make functional OCT techniques useful in performing multimodal imaging, where differently contrasted images are produced in a single examination. We propose a method that further extends the current capabilities of OCT and requires no modifications to the system...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29913368/a-set-up-for-simultaneous-measurement-of-second-harmonic-generation-and-streaming-potential-and-some-test-applications
#15
Johannes Lützenkirchen, Tim Scharnweber, Tuan Ho, Alberto Striolo, Marialore Sulpizi, Ahmed Abdelmonem
We present a measurement cell that allows simultaneous measurement of second harmonic generation (SHG) and streaming potential (SP) at mineral-water interfaces with flat specimen that are suitable for non-linear optical (NLO) studies. The set-up directly yields SHG data for the interface of interest and can also be used to obtain information concerning the influence of flow on NLO signals from that interface. The streaming potential is at present measured against a reference substrate (PTFE). The properties of this inert reference can be independently determined for the same conditions...
June 15, 2018: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29911413/gas-temperature-measurement-using-differential-optical-absorption-spectroscopy-doas
#16
Qiang Gao, Wubin Weng, Bo Li, Marcus Aldén, Zhongshan Li
A nonintrusive method for flow gas temperature measurement using differential optical absorption spectroscopy (DOAS) was demonstrated. A temperature-dependent spectra (TDS) originated from the DOAS spectra of sulfur dioxide (SO2 ) in the wavelength range of 276-310 nm was introduced, and the relationship between the TDS and the temperature was built through experimental calibration process. This relationship is found to be independent of SO2 concentration and can be used for temperature measurements. The experimental results indicated that the precision of the TDS method is < ± 0...
January 1, 2018: Applied Spectroscopy
https://www.readbyqxmd.com/read/29910826/karymsky-volcano-eruptive-plume-properties-based-on-misr-multi-angle-imagery-and-volcanological-implications
#17
Verity J B Flower, Ralph A Kahn
Space-based, operational instruments are in unique positions to monitor volcanic activity globally, especially in remote locations or where suborbital observing conditions are hazardous. The Multi-angle Imaging SpectroRadiometer (MISR) provides hyper-stereo imagery, from which the altitude and microphysical properties of suspended atmospheric aerosols can be derived. These capabilities are applied to plumes emitted at Karymsky volcano from 2000 to 2017. Observed plumes from Karymsky were emitted predominantly to an altitude of 2-4 km, with occasional events exceeding 6 km...
2018: Atmospheric Chemistry and Physics
https://www.readbyqxmd.com/read/29908703/rate-constant-determination-of-interconverting-enantiomers-by-chiral-chromatography-using-a-stochastic-model
#18
Annamária Sepsey, Dóra Rita Németh, Gábor Németh, Attila Felinger
It may happen under the conditions employed that enantiomers interconvert to each other. In this case, obviously, the kinetics of the process is to be examined. When enantiomers dynamically interconvert to each other during the separation process, a plateau is observed between the adjacent peaks (so-called Batman peak appears). The peak shape depends on the rate constant of this dynamic reaction. A novel stochastic model was derived which takes both the separation and the interconversion into account at the molecular level - thus the effects of the parameters affecting the separation can be investigated...
June 6, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29907430/improving-estimates-of-groundwater-velocity-in-a-fractured-rock-borehole-using-hydraulic-and-tracer-dilution-methods
#19
Carlos H Maldaner, Patrick M Quinn, John A Cherry, Beth L Parker
A straddle-packer system for use in boreholes in fractured rock was modified to investigate the average linear groundwater velocity (v¯f ) in fractures under ambient flow conditions. This packer system allows two different tests to be conducted in the same interval between packers without redeploying the system: (1) forced gradient hydraulic tests to determine the interval transmissivity (T), and (2) borehole dilution experiments to determine the groundwater flow rate (Qt ) across the test interval. The constant head step test method provides assurance that flow is Darcian when determining T for each interval and identifies the flow rate at the onset of non-Darcian flow...
May 17, 2018: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/29907330/blood-flow-patterns-and-pressure-loss-in-the-ascending-aorta-a-comparative-study-on-physiological-and-aneurysmal-conditions
#20
Utku Gülan, Christelle Calen, Firat Duru, Markus Holzner
An aortic aneurysm is defined as a balloon-shaped bulging of all three histologic components of the aortic vessel walls (intima, media and adventitia). This dilation results from vessel weakening owing to remodeling, i.e. due to cystic degeneration of the Tunica media (Marfan), progression of atherosclerosis or presence of a bicuspid aortic valve. The growth rate of the aortic diameter varies from patient to patient and may progress until the aneurysm ultimately ruptures. The role of hemodynamics, i.e. blood flow patterns, and shear stresses that are supposed to intensify during aneurysm growth are not yet fully understood, but thought to play a key role in the enlargement process...
June 8, 2018: Journal of Biomechanics
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