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https://www.readbyqxmd.com/read/29052035/why-a-surgically-treated-humeral-shaft-fracture-became-a-nonunion-review-of-11%C3%A2-years-in-two-trauma-centers
#1
A Maresca, P Sangiovanni, S Cerbasi, R Politano, R Fantasia, M Commessatti, R Pascarella
AIM: The aim of this study was to evaluate nonunion causes of surgically treated humeral shaft fractures in two different trauma centers. METHODS: A total of 327 cases of humeral shaft fractures were treated in 11 years in two trauma centers. We retrospectively reviewed in detail some factors in order to understand the reasons for nonunion: (1) fracture type, according to the AO classification, (2) grade of open fracture, according to Gustilo-Anderson, (3) timing, (4) reduction and (5) fixation...
October 19, 2017: Musculoskeletal Surgery
https://www.readbyqxmd.com/read/29051476/independent-factors-predicting-postoperative-30-day-mortality-in-101-infants-following-liver-transplantation
#2
Chan Woo Cho, Sanghoon Lee, Jong Man Kim, Gyu-Seong Choi, Choon Hyuck David Kwon, Jae-Won Joh, Suk-Koo Lee
BACKGROUND Liver transplantation (LT) in infants is a challenging procedure. This study was designed to identify risk factors of 30-day mortality of infant LT recipients. MATERIAL AND METHODS A total of 101 infants treated between May 1997 and March 2015 were assigned to one of two groups, a deceased infant group (n=9) or a live infant group (n=92), according to their mortality status at 30 days after LT. RESULTS Patient characteristics of height, weight, preoperative total bilirubin, creatinine clearance, primary diagnosis, and graft-to-recipient weight ratio (GRWR) were significantly different between the two groups...
October 20, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/29051021/anti-pdgfra-antibodies-predict-for-response-to-nilotinib-in-steroid-refractory-dependent-cgvhd
#3
George L Chen, Paul A Carpenter, Raewyn Broady, Tara K Gregory, Laura J Johnston, Barry E Storer, Jan H Beumer, Jingxin Qiu, Kiara Cerda, Ryan Le, Joanne M Otani, Hong Liu, Maureen A Ross, Sally Arai, Mary E D Flowers, Philip L McCarthy, David B Miklos
Imatinib has clinical activity in chronic graft-versus-host disease (cGvHD), a significant complication of allogeneic hematopoietic cell transplant. Nilotinib is a tyrosine kinase inhibitor that targets the same receptors as imatinib but with different affinities. We tested the hypothesis that nilotinib is safe and has clinical activity in cGvHD. 33 participants were enrolled in a phase 1/2 dose escalation and dose extension clinical trial of nilotinib for the treatment of steroid refractory or dependent cGvHD (ClinicalTrials...
October 16, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29050128/-lung-transplantation-for-connective-tissue-disease-associated-interstitial-lung-disease-recipient
#4
J Zhang, B Wu, M Zhou, D Liu, L Fan, D Wei, H Yang, J Y Chen
Objective: To investigate the timing and complications of lung transplantation for the treatment of connective tissue disease-associated interstitial lung disease (CTD-ILD). Method: The clinical data of connective tissue-associated disease lung transplantation recipients from September, 2015 to February, 2017 were collected. Results: 11 patients with CTD-ILD were evaluated by lung transplantation and were treated with lung transplantation. Including 2 cases dermatomyositis/polymyositis and interstitial lung disease (PM/DM-ILD), 4 cases rheumatoid arthritis and interstitial lung disease (RA-ILD), 4 cases of primary Sjgren's syndrome and interstitial lung disease (pSS-ILD), 1 case of systemic sclerosis and interstitial lung disease (SSc-ILD)...
October 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29049997/discrepancies-between-perceived-and-measured-cognition-in-kidney-transplant-recipients-implications-for-clinical-management
#5
Aditi Gupta, Tashra S Thomas, Jeffrey A Klein, Robert N Montgomery, Jonathan D Mahnken, David K Johnson, David A Drew, Mark J Sarnak, Jeffrey M Burns
BACKGROUND: Cognitive impairment is common in kidney transplant (KT) recipients and affects quality of life, graft survival, morbidity, and mortality. Failure to identify patients with cognitive impairment can withhold appropriate and timely intervention. This study determines whether measured cognition with standard screening tools offers any advantage over perceived cognition in screening transplant patients for cognitive impairment. METHODS: Cognition was assessed in 157 KT recipients using the Montreal Cognitive Assessment (MoCA; measured cognition)...
October 20, 2017: Nephron
https://www.readbyqxmd.com/read/29049838/predicting-long-term-survival-after-coronary-artery-bypass-graft-surgery
#6
Md N Karim, Christopher M Reid, Mollah Huq, Samuel L Brilleman, Andrew Cochrane, Lavinia Tran, Baki Billah
OBJECTIVES: To develop a model for predicting long-term survival following coronary artery bypass graft surgery. METHODS: This study included 46 573 patients from the Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZCTS) registry, who underwent isolated coronary artery bypass graft surgery between 2001 and 2014. Data were randomly split into development (23 282) and validation (23 291) samples. Cox regression models were fitted separately, using the important preoperative variables, for 4 'time intervals' (31-90 days, 91-365 days, 1-3 years and >3 years), with optimal predictors selected using the bootstrap bagging technique...
October 6, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049817/long-term-patency-of-on-and-off-pump-coronary-artery-bypass-grafting-with-bilateral-internal-thoracic-arteries-the-significance-of-late-string-sign-development-in-the-off-pump-technique
#7
Yasunari Hayashi, Atsuo Maekawa, Sadanari Sawaki, Masayoshi Tokoro, Junji Yanagisawa, Takahiro Ozeki, Akihiko Usui, Toshiaki Ito
OBJECTIVES: This study aimed to examine the effect of off-pump coronary artery bypass grafting (CABG) in patients who underwent revascularization with bilateral internal thoracic arteries (ITAs). METHODS: Between January 2000 and December 2014, 499 patients underwent isolated CABG with bilateral ITAs for complete revascularization of the left coronary system at our institution. On-pump CABG was performed in 137 patients, and off-pump CABG was performed in 362 patients...
July 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049665/reoperation-for-mitral-paravalvular-leak-a-single-centre-experience-with-200-patients
#8
Sameh M Said, Hartzell V Schaff, Kevin L Greason, Alberto Pochettino, Richard C Daly, Joseph A Dearani
OBJECTIVES: Paravalvular leak (PVL) is a major cause of morbidity and mortality after mitral valve replacement. Risk factors and data on long-term surgical outcomes are lacking. METHODS: Between January 1995 and December 2012, 206 [118 males (57%)] patients underwent reoperation due to mitral PVL. Mean age was 64 ± 11 years. Haemolytic anaemia was present in 85 (41%) patients, while 137 (67%) patients were in New York Heart Association Class III or IV. Baseline creatinine was above 1...
July 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049617/survival-results-of-postoperative-coronary-angiogram-for-treatment-of-perioperative-myocardial-ischaemia-following-coronary-artery-bypass-grafting-a-single-centre-experience
#9
Maximilian J Preußer, Jan Landwehrt, Stefano Mastrobuoni, Fausto Biancari, Abdul R Dakkak, Mosab Alshakaki, Sven Martens, Angelo M Dell'Aquila
OBJECTIVES: Although perioperative myocardial ischaemia (PMI) is a well-known complication following coronary artery bypass grafting (CABG), standard strategies for its diagnosis and treatment are so far not defined. In this study, we sought to evaluate the impact on survival of postoperative coronary angiogram for management of patients with PMI after CABG. METHODS: Overall, 4028 patients underwent isolated CABG in a single-centre institution between January 2006 and September 2013...
September 26, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049612/long-term-change-in-the-risk-of-skin-cancer-after-organ-transplantation-a-population-based-nationwide-cohort-study
#10
Syed Mohammad Husain Rizvi, Bjarte Aagnes, Hallvard Holdaas, Einar Gude, Kristin Muri Boberg, Øystein Bjørtuft, Per Helsing, Torbjørn Leivestad, Bjørn Møller, Petter Gjersvik
Importance: The high risk of skin cancer after organ transplantation is a major clinical challenge and well documented, but reports on temporal trends in the risk of posttransplant cutaneous squamous cell carcinoma (SCC) are few and appear contradictory. Objective: To study temporal trends for the risk of skin cancer, particularly SCC, after organ transplantation. Design, Setting, and Participants: Population-based, nationwide, prospective cohort study of 8026 patients receiving a kidney, heart, lung, or liver transplant in Norway from 1968 through 2012 using patient data linked to a national cancer registry...
October 18, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/29049508/outcomes-in-women-and-minorities-compared-with-white-men-1-year-after-everolimus-eluting-stent-implantation-insights-and-results-from-the-platinum-diversity-and-promus-element-plus-post-approval-study-pooled-analysis
#11
Wayne Batchelor, David E Kandzari, Scott Davis, Luis Tami, John C Wang, Islam Othman, Osvaldo S Gigliotti, Amir Haghighat, Sarabjeet Singh, Mario Lopez, Gregory Giugliano, Phillip A Horwitz, Jaya Chandrasekhar, Paul Underwood, Craig A Thompson, Roxana Mehran
Importance: There exist limited outcomes data for women and minorities after contemporary percutaneous coronary intervention (PCI). Objective: To examine 1-year outcomes in women and minorities vs white men after PCI with everolimus-eluting stents. Design, Settings, and Participants: The PLATINUM Diversity study was a single-arm study enrolling women and minorities. Patient-level pooling with the PROMUS Element Plus Post-Approval Study was prespecified...
October 18, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29049458/long-term-outcomes-of-multiple-arterial-coronary-artery-bypass-grafting-a-population-based-study-of-patients-in-british-columbia-canada
#12
Aihua Pu, Lillian Ding, Jungwon Shin, Joel Price, Peter Skarsgard, Daniel R Wong, John Bozinovski, Guy Fradet, James G Abel
Importance: Although the long-term survival advantage of multiple arterial grafting (MAG) vs the standard use of left internal thoracic artery (LITA) supplemented by saphenous vein grafts (LITA+SVG) has been demonstrated in several observational studies, to our knowledge its safety and other long-term clinical benefits in a large, population-based cohort are unknown. Objective: To compare the safety and long-term outcomes of MAG vs LITA+SVG among overall and selected subgroups of patients...
October 11, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29049202/mandibular-gorham-stout-disease-a-case-report-and-literature-review
#13
Min Liu, Weiwei Liu, Chunyan Qiao, Bing Han
RATIONALE: Gorham-Stout disease (GSD) is characterized by aggressive bone resorption, proliferation of vascular or lymphatic vessels, and soft-tissue swelling. Bones that initially appear normal start to resorb, partially or completely. However, the etiology of GSD is unknown. PATIENT CONCERNS: A 29-year-old man with a chief complaint of toothache and mobility in the lower right mandible for the previous 1 year. DIAGNOSES: Gorham-Stout disease (GSD)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048463/interleukin-9-mediates-chronic-kidney-disease-dependent-vein-graft-disease-a-role-for-mast-cells
#14
Lisheng Zhang, Jiao-Hui Wu, James C Otto, Susan B Gurley, Elizabeth R Hauser, Sudha K Shenoy, Karim Nagi, Leigh Brian, Virginia Wertman, Natalie Mattocks, Jeffrey H Lawson, Neil J Freedman
Aims: Chronic kidney disease (CKD) is a powerful independent risk factor for cardiovascular events, including vein graft failure. Because CKD impairs the clearance of small proteins, we tested the hypothesis that CKD exacerbates vein graft disease by elevating serum levels of critical cytokines that promote vein graft neointimal hyperplasia. Methods and results: We modelled CKD in C57BL/6 mice with 5/6ths nephrectomy, which reduced glomerular filtration rate by 60%, and we modelled vein grafting with inferior-vena-cava-to-carotid interposition grafting...
August 31, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/29044859/testing-feasibility-of-an-accurate-microscopic-assessment-of-macrovesicular-steatosis-in-liver-allograft-biopsies-by-smartphone-add-on-lenses
#15
Manuela Cesaretti, Nicolas Poté, Federica Dondero, François Cauchy, Anne Sophie Schneck, Olivier Soubrane, Valerie Paradis, Alberto Diaspro, Andrea Antonini
Light microscopy is an essential tool in histological examination of tissue samples. However, the required equipment for a correct and rapid diagnosis is sometimes unavailable. Smartphones and mobile phone networks are widespread, and could be used for diagnostic imaging and telemedicine. Macrovesicular steatosis (MS) is a major risk factor for liver graft failure, and is only assessable by microscopic examination of a frozen tissue section. The aim of this study was to compare the microscopic assessment of MS in liver allograft biopsies by a smartphone with eyepiece adaptor (BLIPS device) to standard light microscopy...
October 17, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29044729/outcome-comparison-of-liver-transplantation-for-hepatitis-a-related-versus-hepatitis-b-related-acute-liver-failure-in-adult-recipients
#16
Dong-Hwan Jung, Shin Hwang, Young-Suk Lim, Ki-Hun Kim, Chul-Soo Ahn, Deok-Bog Moon, Tae-Yong Ha, Gi-Won Song, Gil-Chun Park, Sung-Gyu Lee
Hepatitis A virus (HAV) can cause acute liver failure (ALF). This study compares outcomes between liver transplantation (LT) for HAV-related ALF (HAV-ALF) and LT for Hepatitis B virus (HBV)-related ALF (HBV-ALF). Of 3,616 adult LTs performed between January 2005 and December 2014, we performed LT for HAV-ALF recipients (n = 29) and LT for HBV-ALF recipients (n = 34). HAV-ALF group included 18 males and 11 females with mean age of 33.1 years. Graft survival rates in HAV-ALF and HBV-ALF were 65.5% and 88.0% (1 year) and 65...
October 17, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29043440/-boston-keratoprosthesis-73%C3%A2-eyes-from-germany-an-overview-of-experiences-from-two-centers
#17
F Schaub, I Neuhann, P Enders, B O Bachmann, B Koller, T Neuhann, C Cursiefen
BACKGROUND: The Boston Keratoprosthesis (B-KPro) is a therapeutic option for corneal replacement for visual rehabilitation in eyes with poor a prognosis for penetrating keratoplasty (high-risk eyes). Since 2009, this approach has been used in the MVZ Prof. Neuhann, Munich, and since 2013 also at the Department of Ophthalmology, University of Cologne. An overview of results from the first 73 eyes in these departments is presented. METHODS: All recipient eyes of both centers which received a B-KPro type I (BI-KPro) between November 2009 and March 2017 were included...
October 17, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/29039128/distal-femoral-flexion-deformity-from-growth-disturbance-treated-with-a-two-level-osteotomy-and-internal-lengthening-nail
#18
Austin T Fragomen, Fiona R Fragomen
Salter Harris fractures of the distal femur can lead to growth disturbance with resulting leg length inequality and knee deformity. We have looked at a case series (3) of patients who presented with a distal femur flexion malunion and shortening treated with a distal femoral osteotomy and plating and a proximal femoral osteotomy with a magnetic internal lengthening nail. Does a two-level osteotomy and internal fixation approach provide a reliable result both radiographically and functionally? The average knee extension loss was 12°, LLD 47 mm, PDFA 65°, MAD 2 mm...
October 16, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/29037148/effectiveness-of-a-precede-based-education-intervention-on-quality-of-life-in-elderly-patients-with-chronic-heart-failure
#19
Qiong Wang, Lini Dong, Zaijin Jian, Xianghua Tang
BACKGROUND: One of the most important challenges in public health is to improve the quality of life in patients with chronic heart failure (CHF). Depression, self-care capacity, and quality of life interact each other in these patients. It's difficult to treat with general education programs and conventional therapy. PRECEDE model is a comprehensive and exclusive theory-based education programs. Its effectiveness for reducing depression and increasing quality of life has been demonstrated in patients with coronary artery bypass grafting, type 2 diabetes, and the elderly...
October 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29034014/improving-the-outcome-of-vein-grafts-should-vascular-surgeons-turn-veins-into-arteries
#20
REVIEW
Toshihiko Isaji, Takuya Hashimoto, Kota Yamamoto, Jeans M Santana, Bogdan Yatsula, Haidi Hu, Hualong Bai, Guo Jianming, Tambudzai Kudze, Toshiya Nishibe, Alan Dardik
Autogenous vein grafts remain the gold standard conduit for arterial bypass, particularly for the treatment of critical limb ischemia. Vein graft adaptation to the arterial environment, i.e., adequate dilation and wall thickening, contributes to the superior performance of vein grafts. However, abnormal venous wall remodeling with excessive neointimal hyperplasia commonly causes vein graft failure. Since the PREVENT trials failed to improve vein graft outcomes, new strategies focus on the adaptive response of the venous endothelial cells to the post-surgical arterial environment...
March 24, 2017: Annals of Vascular Diseases
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