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https://www.readbyqxmd.com/read/29933250/association-of-inflow-cannula-position-with-left-ventricular-unloading-and-clinical-outcomes-in-patients-with-heartmate-ii-left-ventricular-assist-device
#1
Teruhiko Imamura, Ann Nguyen, Ben Chung, Daniel Rodgers, Nitasha Sarswat, Gene Kim, Jayant Raikhelkar, Sirtaz Adatya, Takeyoshi Ota, Tae Song, Colleen Juricek, Jerry D Estep, Daniel Burkhoff, Valluvan Jeevanandam, Gabriel Sayer, Nir Uriel
The relationship between the HeartMate II left ventricular assist device (LVAD) position and pump thrombosis has been reported. However, further clinical implications of device position are unknown. This study aimed to investigate optimal device position for better left ventricular (LV) unloading and patient prognosis. Patients undergoing a ramp test with right heart catheterization after HeartMate II LVAD implantation were enrolled to this study. Device position was quantified from the chest X-ray obtained at the time of the ramp test: (1) inflow cannula angle relative to horizontal line, (2) pump angle relative to spine, (3) pump depth, (4) angle between inflow cannula and pump, and (5) angle between pump and outflow graft...
June 19, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29933079/treatment-of-cyclosporine-induced-hypertension-results-from-a-long-term-observational-study-using-different-antihypertensive-medications
#2
Kim Marienhagen, Frank Lehner, Jürgen Klempnauer, Hartmut Hecker, Jürgen Borlak
Post-transplant hypertension (PTH) is a common complication in cyclosporine immunosuppressed patients; however choosing the right antihypertensive medication is challenging. In a long-term observational study (≤13y) we examined different antihypertensive medications on graft/patient survival of kidney recipients with pre-existing and PTH. Altogether thirty-three co-variables were analyzed including dose and type of immunosuppressive and antihypertensive medication, co-medications, serum biochemistries and the glomerular filtration rate (GFR)...
June 19, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29933073/cc-486-maintenance-after-stem-cell-transplantation-in-patients-with-acute-myeloid-leukemia-or-myelodysplastic-syndromes
#3
Marcos de Lima, Betul Oran, Richard E Champlin, Esperanza B Papadopoulos, Sergio A Giralt, Bart L Scott, Basem M William, Joel Hetzer, Eric Laille, Becky Hubbell, Barry S Skikne, Charles Craddock
BACKGROUND: Relapse is the main cause of treatment failure after allogeneic stem cell transplant (alloSCT) in acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS). Injectable azacitidine can improve posttransplant outcomes but presents challenges with exposure and compliance. Oral CC-486 allows extended dosing to prolong azacitidine activity. We investigated use of CC-486 maintenance therapy post-alloSCT. METHODS: Adults with MDS or AML in morphological complete remission at CC-486 initiation (42-84 days post-alloSCT) were included...
June 19, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29932154/future-of-smart-cardiovascular-implants
#4
REVIEW
Anubhav Bussooa, Steven Neale, John R Mercer
Cardiovascular disease remains the leading cause of death in Western society. Recent technological advances have opened the opportunity of developing new and innovative smart stent devices that have advanced electrical properties that can improve diagnosis and even treatment of previously intractable conditions, such as central line access failure, atherosclerosis and reporting on vascular grafts for renal dialysis. Here we review the latest advances in the field of cardiovascular medical implants, providing a broad overview of the application of their use in the context of cardiovascular disease rather than an in-depth analysis of the current state of the art...
June 22, 2018: Sensors
https://www.readbyqxmd.com/read/29930684/late-open-conversion-in-ruptured-abdominal-aortic-aneurysm-after-endovascular-repair
#5
Erol Kurç, Onur Sokullu, Serdar Akansel, Murat Sargın
Despite technological advances, the long-term outcomes of endovascular aortic aneurysm repair (EVAR) are still debatable. Although most endograft failures after EVAR can be corrected with endovascular techniques, open conversion may still be required. A 70-year-old male patient presented at the emergency unit with abdominal pain. Twice, in the third and fourth years after the first repair, a stent graft had been placed over a non-adhesive portion of the stent graft due to type Ia endoleaks. In the most recent admission, a CT scan showed type III endoleak and ruptured aneurysm sac...
January 2018: Jornal Vascular Brasileiro
https://www.readbyqxmd.com/read/29928848/retrospective-evaluation-of-fidaxomicin-versus-oral-vancomycin-for-treatment-of-clostridium-difficile-infections-in-allogeneic-stem-cell-transplant
#6
Laura Prohaska, Zahra Mahmoudjafari, Leyla Shune, Anurag Singh, Tara Lin, Sunil Abhyankar, Siddhartha Ganguly, Dennis Grauer, Joseph McGuirk, Lisa Clough
OBJECTIVE/BACKGROUND: Clostridium difficile infection (CDI) is a potential complication during hematopoietic stem cell transplantation (HSCT), and no specific recommendations exist regarding treatment of CDI in allogeneic SCT patients. Use of metronidazole and oral vancomycin has been associated with clinical failure. Fidaxomicin has previously been found noninferior to the use of oral vancomycin for the treatment of CDI, and no studies have compared the use of oral vancomycin with fidaxomicin for the treatment of CDI in allogeneic SCT...
June 18, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29928125/graft-outcomes-following-immunosuppressive-therapy-with-different-combinations-in-kidney-transplant-recipients-a-nationwide-cohort-study
#7
Yung-Fong Tsai, Fu-Chao Liu, Chang-Fu Kuo, Ting-Ting Chung, Huang-Ping Yu
Background: Immunosuppression plays an essential role to overcome immune-related allograft rejection, but it also causes some nephrotoxicity. This study aimed to investigate how the immunosuppressant combinations affect graft outcomes in kidney transplant recipients. Methods: A nationwide population-based cohort study using the Taiwan National Health Insurance Database was conducted. A total of 3,441 kidney transplant recipients who underwent kidney transplantation during the targeted period were included...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29927031/fecal-pancreatic-elastase-1-in-the-evaluation-of-pancreatic-function-after-pediatric-intestinal-transplantation
#8
Stuart S Kaufman, Xiaogang Simon Zhong, Ahmed M Elsabbagh, Dominique Bailey, Nada A Yazigi, Khalid M Khan, Cal S Matsumoto
Fat malabsorption is common after SBT. To identify whether anatomic variant transplants differ in occurrence of exocrine pancreatic insufficiency that could contribute to fat malabsorption, we measured FPE repeatedly in 54 recipients of a SBT, ages 6.2 to 320 months. FPE determination most distant from SBT was 6.1 years. Of the 54, 39% received an isolated intestinal graft (native pancreas only), 48% received an en bloc liver-intestinal-pancreas graft (native and graft pancreas), and 13% received a multivisceral graft (graft pancreas only)...
June 21, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29926359/breakthrough-infection-of-geotrichum-capitatum-during-empirical-caspofungin-therapy-after-umbilical-cord-blood-transplantation
#9
Shuki Oya, Tsuyoshi Muta
We experienced a breakthrough fungal infection caused by Geotrichum capitatum during empirical therapy with caspofungin. A 68-year-old male patient with refractory acute lymphoblastic leukemia had received umbilical cord blood transplantation after two courses of induction therapy. Empirical therapy with caspofungin was initiated 5 days before transplantation. Tacrolimus was continuously infused to prevent graft-versus-host disease. A minidose of methotrexate was intravenously administered on days 1 and 3 post-transplantation, which was changed to prednisolone from day 7 due to severe mucositis...
June 20, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29925095/coronary-artery-bypass-grafting-in-diabetic-patients-complete-arterial-versus-internal-thoracic-artery-and-sequential-vein-grafts-a-propensity-score-matched-analysis
#10
Takashi Kunihara, Olaf Wendler, Kerstin Heinrich, Ryota Nomura, Hans-Joachim Schäfers
BACKGROUND:  The optimal choice of conduit and configuration for coronary artery bypass grafting (CABG) in diabetic patients remains somewhat controversial, even though arterial grafts have been proposed as superior. We attempted to clarify the role of complete arterial revascularization using the left internal thoracic artery (LITA) and the radial artery (RA) alone in "T-Graft" configuration on long-term outcome. METHODS AND RESULTS:  From 1994 to 2001, 104 diabetic patients with triple vessel disease underwent CABG using LITA/RA "T-Grafts" (Group-A)...
June 20, 2018: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/29924790/-surgical-treatment-of-total-thrombosis-of-an-abdominal-aortic-endograft
#11
V V Shlomin, I V Kas'ianov, I G Drozhzhin, P B Bondarenko, P D Puzdriak
Described in the article is a clinical case report regarding successful surgical treatment of total thrombosis of a stent graft in a high-risk surgical patient, having previously undergone endovascular repair of an abdominal aortic aneurysm by means of a unilateral stent graft with suprarenal fixation of its crown and femorofemoral crossover bypass grafting. 5 months after the operation, the patient began complaining of rest pain in his right leg and trophic ulcers of the foot. The findings of MSCT angiography revealed total thrombosis of the stent graft, to be later on followed by operative intervention, i...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29924638/outcomes-of-alveolar-graft-with-rhbmp-2-in-clp-influence-of-cleft-type-and-width-canine-eruption-and-surgeon
#12
Claudia Resende Leal, Roberta Martinelli de Carvalho, Terumi Okada Ozawa, Araci Malagodi de Almeida, Gisele da Silva Dalben, José Carlos da Cunha Bastos, Daniela Gamba Garib Carreira
OBJECTIVE: To evaluate the influence of cleft type and width, canine eruption stage, and surgeon on the outcomes of alveolar graft with rhBMP-2. DESIGN: Cross-sectional. SETTING: Tertiary craniofacial center. PARTICIPANTS: Ninety individuals submitted to alveolar graft in late mixed or early permanent dentition. INTERVENTIONS: The 90 individuals (mean age: 16.8 years) were submitted to alveolar graft with rhBMP-2...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29924203/descemet-membrane-endothelial-keratoplasty-dmek-intraoperative-and-postoperative-complications-and-clinical-results
#13
Yusuf Koçluk, Burcu Kasım, Emine Alyamaç Sukgen, Ayşe Burcu
PURPOSE: To evaluate the complications and clinical results of Descemet membrane endothelial keratoplasty (DMEK) in patients with endothelial failure that occurred during the learning curve of a surgeon. METHODS: Fifty eyes of 50 patients with DMEK and ≥6 months of follow-up were included. The patients were divided into the first 25 (group 1) and the second 25 (group 2) procedures performed by the surgeon. Best corrected visual acuity (BCVA), central corneal thickness (CCT), unfolding time of the Descemet membrane (DM) graft, and intraoperative and postoperative complications were compared between groups...
June 2018: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/29923302/pro-steroids-can-be-withdrawn-posttransplant-in-recipients-with-autoimmune-hepatitis
#14
REVIEW
Avash Kalra, James R Burton, Lisa Forman
Corticosteroids have been a mainstay of immunosuppression following liver transplantation. However, evolution in the field of transplant immunology has produced steroid-free options, resulting in most transplant centers weaning steroids post-transplant within days to months - an evidence-based management decision. Patients with autoimmune hepatitis, however, receive corticosteroids prior to transplant. This raises the question of whether these patients should also be weaned from corticosteroids. In this review, we discuss the benefits of avoiding steroid use in this population of patients - an approach that not only avoids the adverse effects of corticosteroids, but does so without risking graft failure from recurrent autoimmune hepatitis or from acute cellular rejection...
June 19, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29922525/spanning-external-fixation-for-the-treatment-of-open-joint-injuries-in-pediatric-burn-patients
#15
Kelly Carmichael, Daniel Torres, Carlos J Jimenez, Matthew C Comley, Ernest B Evans
In this article, we report a case series on spanning external fixation for the treatment of open joint burn injuries in a pediatric population. We reviewed the case logs of all orthopedic surgeons from 2000 to 2010 at a burn hospital to identify pediatric patients with open joints secondary to burn injuries. Nine patients who sustained open joint injuries after a burn and treated with a spanning external fixator (SEF) were identified. Characteristics of the burns included: five elbow, four knee; seven flame, two electrical; average total body surface area affected 49...
April 16, 2018: Curēus
https://www.readbyqxmd.com/read/29922452/the-effect-of-femoral-bone-tunnel-configuration-on-tendon-bone-healing-in-an-anterior-cruciate-ligament-reconstruction-an-animal-study
#16
Y Sato, R Akagi, Y Akatsu, Y Matsuura, S Takahashi, S Yamaguchi, T Enomoto, R Nakagawa, H Hoshi, T Sasaki, S Kimura, Y Ogawa, A Sadamasu, S Ohtori, T Sasho
Objectives: To compare the effect of femoral bone tunnel configuration on tendon-bone healing in an anterior cruciate ligament (ACL) reconstruction animal model. Methods: Anterior cruciate ligament reconstruction using the plantaris tendon as graft material was performed on both knees of 24 rabbits (48 knees) to mimic ACL reconstruction by two different suspensory fixation devices for graft fixation. For the adjustable fixation device model (Socket group; group S), a 5 mm deep socket was created in the lateral femoral condyle (LFC) of the right knee...
May 2018: Bone & Joint Research
https://www.readbyqxmd.com/read/29921952/descemet-s-membrane-endothelial-keratoplasty-surgical-outcomes-and-endothelial-cell-count-modelling-from-a-uk-centre
#17
Mark A P Fajgenbaum, Nick Kopsachilis, Emma J Hollick
PURPOSE: To report surgical outcomes and endothelial cell density (ECD) trends up to 2 years post-operatively in the first cohort of eyes undergoing Descemet's membrane endothelial keratoplasty (DMEK) for low-to-moderate risk indications at our UK centre. Tight corneal sutures were used to ensure high intraoperative pressure from intracameral air for 10-min and to maintain a good post-operative air fill. Outcomes were compared to a prior series at our unit of similar eyes having Descemet's stripping endothelial keratoplasty (DSEK)...
June 19, 2018: Eye
https://www.readbyqxmd.com/read/29921223/from-debulking-to-delivery-sequential-use-of-rotational-atherectomy-and-guidezilla%C3%A2-for-complex-saphenous-vein-grafts-intervention
#18
Mariano Pellicano, Vincent Floré, Emanuele Barbato, Bernard De Bruyne
BACKGROUND: Percutaneous coronary interventions (PCI) of old calcified saphenous vein grafts (SVGs) is challenging and is associated with a considerably high risk of adverse ischemic events in the short- and long-term as compared to native coronary arteries. We report a case in which a non-dilatable, calcified SVG lesion is successfully treated with rotational atherectomy followed by PCI and stenting with local stent delivery (LSD) technique using the Guidezilla™ guide extension catheter (5-in-6 Fr) in the "child-in-mother" fashion...
June 19, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29920894/cicatricial-ectropion-surgery-a-prospective-study-of-long-term-symptom-control-patient-satisfaction-and-anatomical-success
#19
James McKelvie, Taras Papchenko, Stuart Carroll, Stephen Gj Ng
IMPORTANCE: Cicatricial ectropion repair is effective and has a low complication rate. BACKGROUND: To evaluate the effectiveness and long-term functional outcomes of surgical repair of lower-lid cicatricial ectropion. DESIGN: Prospective consecutive case series. PARTICIPANTS: Forty-four consecutive operations for cicatricial ectropion repair METHODS: Consecutive cases of cicatricial ectropion repair completed during 2007-2011 in Waikato Hospital and Hamilton Eye Clinic, New Zealand were enrolled in the study following formal ethics approval...
June 19, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29916988/understanding-the-correlation-between-dsa-complement-activation-and-antibody-mediated-rejection-in-heart-transplant-recipients
#20
Qiuheng Zhang, Michelle Hickey, Diana Drogalis-Kim, Ying Zheng, David Gjertson, Martin Cadeiras, Tam Khuu, Arnold S Baas, Eugene C Depasquale, Nancy J Halnon, Gregory Perens, Juan Alejos, Daniel Cruz, Nsair Ali, Richard Shemin, Murray Kwon, Michael C Fishbein, Abbas Ardehali, Mario Deng, Elaine F Reed
BACKGROUND: Donor specific HLA antibodies (DSA) are associated with increased rates of rejection and of graft failure in cardiac transplantation. The goal of this study was to determine the association of preformed and posttransplant development of newly detected DSA (ndDSA) with antibody mediated rejection (AMR) and characterize the clinical relevance of complement activating DSA in heart allograft recipients. METHODS: The study included 128 adult and 48 pediatric heart transplant patients transplanted between 2010 to 2013...
June 18, 2018: Transplantation
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