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attention deficiency hyperactivity disorder

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https://www.readbyqxmd.com/read/29207797/audit-of-organic-acidurias-from-a-single-centre-clinical-and-metabolic-profile-at-presentation-with-long-term-outcome
#1
Seema Pavaman Sindgikar, Krithika Damodar Shenoy, Nutan Kamath, Rathika Shenoy
Introduction: Organic Acidurias (OA) accounts between 10% and 40% of confirmed Inborn Errors of Metabolism (IEM) in India. With prompt recognition and management, better survival but adverse neurodevelopmental outcome is reported. Aim: To study the clinical and metabolic presentation, management with immediate and long term outcome of symptomatic children with confirmed OA. Materials and Methods: Hospital based study of symptomatic children diagnosed to have OA between 2003 and 2009 and the survivors followed up over next five years...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29178023/emotion-self-regulation-moderates-the-association-between-symptoms-of-adhd-and-weight-loss-after-bariatric-surgery
#2
Tamara M Williamson, Tavis S Campbell, Jo Ann Telfer, Joshua A Rash
BACKGROUND: This study aimed to examine the combined effect of pre-surgical emotion self-regulation (ESR) and symptoms of attention deficit hyperactivity disorder (sADHD, i.e., inattention, impulsivity, and hyperactivity) on weight loss 12 months following bariatric surgery independent of psychological distress and eating pathology. METHODS: Adults with obesity were recruited from a bariatric surgery specialty clinic in Canada. Patients completed measures of psychological distress (i...
November 24, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29170079/practical-management-of-behavioral-problems-in-mucopolysaccharidoses-disorders
#3
REVIEW
Maria L Escolar, Simon A Jones, Elsa G Shapiro, Dafne D G Horovitz, Christina Lampe, Hernán Amartino
The mucopolysaccharidosis (MPS) disorders are caused by deficiencies of specific lysosomal enzymes, resulting in progressive glycosaminoglycan (GAG) accumulation in cells and tissues throughout the body. Excessive GAG storage can lead to a variety of somatic manifestations as well as primary and secondary neurological symptoms. Behavioral problems (like hyperactivity, attention difficulties, and severe frustration) and sleeping problems are typical primary neurological symptoms of MPS caused by GAG accumulation in neurons, and are frequently observed in patients with MPS I, II, III, and VII...
September 27, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29157002/effects-of-circadian-clock-protein-per1b-on-zebrafish-visual-functions
#4
Ke Nie, Kun Wang, Deng-Feng Huang, Yu-Bin Huang, Wu Yin, Da-Long Ren, Han Wang, Bing Hu
The circadian clock is an endogenous and entrainable time-keeping mechanism with a period of approximately 24 h, operated by transcription/translation feedback loops composed of circadian clock genes and their proteins. The visual system displays robust circadian changes. Relatively little, however, is known about the mechanisms underlying visual circadian rhythmicity. Zebrafish period1b (per1b), as a canonical circadian clock gene, is involved in circadian regulation. Here, we observed that zebrafish per1b mutants exhibit visual defects including reduced behavioral contrast sensitivity and significant retinal dopaminergic deficiency...
November 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29102665/perinatal-exposure-to-low-dose-imidacloprid-causes-adhd-like-symptoms-evidences-from-an-invertebrate-model-study
#5
Seoyoung Kim, Hee-Seok Lee, Yooheon Park
The fundamental diagnoses of attention deficit hyperactivity disorder (ADHD) and autism consists of inattention, hyperactivity, and impulsivity, which lead to abnormal social interactions and repetitive and restricted behavior. Several food contaminants are suspected of being a possible contributing factor to the present-day increase in diseases, such as obesity and ADHD, and pesticides are also considered as a contributor to the increased prevalence of ADHD. Imidacloprid is a neonicotinoid insecticide with lower toxicity to mammals...
November 2, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29070492/vitamin-d-deficiency-infertility-and-neurodevelopmental-diseases-attention-deficit-hyperactivity-disorder-autism-and-schizophrenia
#6
Michael J Berridge
The process of development depends on a progressive sequence of events that are carefully orchestrated by a number of signalling systems. Alteration in these signalling events results in infertility and neurodevelopmental diseases such as attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASD) and schizophrenia. A prominent role throughout development beginning at fertilization and continuing through early development, implantation and organ differentiation such as heart and brain development is regulated by Ca(2+) signalling...
October 25, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29058689/deficiency-of-tumor-suppressor-ndrg2-leads-to-attention-deficit-and-hyperactive-behavior
#7
Yan Li, Anqi Yin, Xin Sun, Ming Zhang, Jianfang Zhang, Ping Wang, Rougang Xie, Wen Li, Ze Fan, Yuanyuan Zhu, Han Wang, Hailong Dong, Shengxi Wu, Lize Xiong
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent psychiatric disorder in children. Although an imbalance of excitatory and inhibitory inputs has been proposed as contributing to this disorder, the mechanisms underlying this highly heterogeneous disease remain largely unknown. Here, we show that N-myc downstream-regulated gene 2 (NDRG2) deficiency is involved in the development of ADHD in both mice and humans. Ndrg2-knockout (Ndrg2-/-) mice exhibited ADHD-like symptoms characterized by attention deficits, hyperactivity, impulsivity, and impaired memory...
October 23, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29018333/cadherin-13-deficiency-increases-dorsal-raphe-5-ht-neuron-density-and-prefrontal-cortex-innervation-in-the-mouse-brain
#8
Andrea Forero, Olga Rivero, Sina Wäldchen, Hsing-Ping Ku, Dominik P Kiser, Yvonne Gärtner, Laura S Pennington, Jonas Waider, Patricia Gaspar, Charline Jansch, Frank Edenhofer, Thérèse J Resink, Robert Blum, Markus Sauer, Klaus-Peter Lesch
Background: During early prenatal stages of brain development, serotonin (5-HT)-specific neurons migrate through somal translocation to form the raphe nuclei and subsequently begin to project to their target regions. The rostral cluster of cells, comprising the median and dorsal raphe (DR), innervates anterior regions of the brain, including the prefrontal cortex. Differential analysis of the mouse 5-HT system transcriptome identified enrichment of cell adhesion molecules in 5-HT neurons of the DR. One of these molecules, cadherin-13 (Cdh13) has been shown to play a role in cell migration, axon pathfinding, and synaptogenesis...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28948974/a-upf3b-mutant-mouse-model-with-behavioral-and-neurogenesis-defects
#9
L Huang, E Y Shum, S H Jones, C-H Lou, J Dumdie, H Kim, A J Roberts, L A Jolly, J L Espinoza, D M Skarbrevik, M H Phan, H Cook-Andersen, N R Swerdlow, J Gecz, M F Wilkinson
Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA degradation pathway that acts on RNAs terminating their reading frames in specific contexts. NMD is regulated in a tissue-specific and developmentally controlled manner, raising the possibility that it influences developmental events. Indeed, loss or depletion of NMD factors have been shown to disrupt developmental events in organisms spanning the phylogenetic scale. In humans, mutations in the NMD factor gene, UPF3B, cause intellectual disability (ID) and are strongly associated with autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD) and schizophrenia (SCZ)...
September 26, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28934990/x-linked-ichthyosis-associated-with-psychosis-and-behavioral-abnormalities-a-case-report
#10
Amna Malik, Ahmed Bait Amer, Mohammed Salama, Bander Haddad, Muhammad T Alrifai, Mohammed Al Balwi, William Davies, Wafaa Eyaid
BACKGROUND: X-linked ichthyosis is a dermatological condition caused by deficiency for the enzyme steroid sulfatase. Previously, X-linked ichthyosis/steroid sulfatase deficiency has been associated with developmental and neurological phenotypes. Here, we show for the first time, that X-linked ichthyosis may be comorbid with an additional psychiatric phenotype (psychosis). CASE PRESENTATION: We report the case of an 11-year-old Saudi Arabian boy with X-linked ichthyosis associated with psychosis, mental retardation, autism spectrum disorder, inattentive attention deficit hyperactivity disorder, and epilepsy...
September 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28844595/cognitive-impairments-associated-with-alterations-in-synaptic-proteins-induced-by-the-genetic-loss-of-adenosine-a2a-receptors-in-mice
#11
Maria Moscoso-Castro, Marc López-Cano, Irene Gracia-Rubio, Francisco Ciruela, Olga Valverde
The study of psychiatric disorders usually focuses on emotional symptoms assessment. However, cognitive deficiencies frequently constitute the core symptoms, are often poorly controlled and handicap individual's quality of life. Adenosine receptors, through the control of both dopamine and glutamate systems, have been implicated in the pathophysiology of several psychiatric disorders such as schizophrenia and attention deficit/hyperactivity disorder. Indeed, clinical data indicate that poorly responsive schizophrenia patients treated with adenosine adjuvants show improved treatment outcomes...
August 26, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28832371/dietary-factors-in-the-etiology-and-therapy-of-attention-deficit-hyperactivity-disorder
#12
Klaus W Lange
PURPOSE OF REVIEW: The purpose of this study is to discuss the role of dietary factors in the etiology and therapy of attention deficit/hyperactivity disorder (ADHD). Relevant literature published from January 2016 to January 2017 was included in this review. RECENT FINDINGS: Unhealthy prenatal diet may be associated with ADHD in the offspring through an increase in epigenetic changes. The few-foods diet may have some efficacy, but requires further investigation before firm conclusions can be drawn...
August 19, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28793231/association-of-mitochondrial-dna-10398-a-g-polymorphism-with-attention-deficit-and-hyperactivity-disorder-in-korean-children
#13
In Wook Hwang, Jun Ho Hong, Bit Na Kwon, Hyung Jun Kim, Noo Ri Lee, Myung Ho Lim, Ho Jang Kwon, Han Jun Jin
Mitochondria are subcellular organelles that contribute to aerobic ATP generation by oxidative phosphorylation (OXPHOS). Previous studies reported that mitochondrial dysfunction and deficiency caused by mitochondrial DNA polymorphisms is associated with various diseases. Especially, mitochondrial DNA 10398 A/G polymorphism is known to affect the regulation of mitochondrial calcium levels related to energy production, and its association with psychiatric disorders such as schizophrenia and bipolar disorder has been reported...
September 30, 2017: Gene
https://www.readbyqxmd.com/read/28791958/the-%C3%AE-7-nach-nicotinic-receptor-and-its-role-in-memory-and-selected-diseases-of-the-central-nervous-system
#14
REVIEW
Urszula Baranowska, Róża Julia Wiśniewska
α7-nACh is one of the major nicotinic cholinergic receptor subtypes found in the brain. It is broadly expressed in the hippocampal and cortical neurons, the regions which play a key role in memory formation. Although α7-nACh receptors may serve as postsynaptic receptors mediating classical neurotransmission, they usually function as presynaptic modulators responsible for the release of other neurotransmitters, such as glutamate, γ-aminobutyric acid, dopamine, and norepinephrine. They can, therefore, affect a wide array of neurobiological functions...
July 30, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28770370/exploring-deficient-emotion-regulation-in-adult-adhd-electrophysiological-evidence
#15
Anna Shushakova, Patricia Ohrmann, Anya Pedersen
Emotional dysregulation (ED) is being increasingly recognized as a core feature of attention-deficit/hyperactivity disorder (ADHD), but the pathophysiological underpinnings remain unclear. In this study, we provide meaningful electrophysiological evidence of ED in adult patients with ADHD (n = 39) compared to healthy controls (n = 40) by exploring the electrophysiological correlates of the emotion regulation strategies reappraisal, distraction, and expressive suppression. Event-related potentials (ERPs) were recorded during passive viewing of neutral and negative images, as well as during emotion regulation...
August 2, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28763482/attention-impairments-and-adhd-symptoms-in-adult-narcoleptic-patients-with-and-without-hypocretin-deficiency
#16
Marco Filardi, Fabio Pizza, Lorenzo Tonetti, Elena Antelmi, Vincenzo Natale, Giuseppe Plazzi
BACKGROUND: Attentional complaints are common in narcolepsy patients and can overlap with daytime sleepiness features. Few studies attempted to characterize attentional domains in narcolepsy leading to controversial results. We aimed to assess the impact of hypocretin deficiency on attentional functioning by comparing performances on the attention network test (ANT) of narcoleptic patients with hypocretin deficiency (narcolepsy type 1-NT1) versus patients without hypocretin deficiency (narcolepsy type 2-NT2) and healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28745216/insights-in-developmental-coordination-disorder
#17
Marie Farmer, Bernard Echenne, Regen Drouin, M Hamed Bentourkia
BACKGROUND: Developmental Coordination Disorder (DCD) is a neurological impairment occurring in nearly 6% of general population, and sometimes mimics other developmental disorders like Attention Deficit Hyperactivity Disorder (ADHD) or, in the most severe cases, intellectual deficiency. OBJECTIVE: We propose in this review a contribution on this matter in order to provide better insights in DCD including clinical symptoms and pathophysiological explanations that would identify this entity from others...
July 26, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28741625/omega-3-polyunsaturated-fatty-acids-in-youths-with-attention-deficit-hyperactivity-disorder-adhd-a-systematic-review-and-meta-analysis-of-clinical-trials-and-biological-studies
#18
JanePei-Chen Chang, Kuan-Pin Su, Valeria Mondelli, Carmine M Pariante
The role of omega-3 polyunsaturated fatty acids (omega-3 or n-3 PUFAs) in the pathogenesis and treatment of children and adolescents with attention deficit hyperactivity disorder (ADHD) is unclear. A systematic review followed by meta-analysis was conducted on: (1) randomized controlled trials (RCTs) assessing the effects of n-3 PUFAs on clinical symptoms and cognition in children and adolescent with ADHD; and (2) case-control studies assessing the levels of n-3 PUFAs in blood and buccal tissues of children and adolescents with ADHD...
July 25, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28740469/neuroligins-nlg2-and-nlg4-affect-social-behavior-in-drosophila-melanogaster
#19
Kristina Corthals, Alina Sophia Heukamp, Robert Kossen, Isabel Großhennig, Nina Hahn, Heribert Gras, Martin C Göpfert, Ralf Heinrich, Bart R H Geurten
The genome of Drosophila melanogaster includes homologs to approximately one-third of the currently known human disease genes. Flies and humans share many biological processes, including the principles of information processing by excitable neurons, synaptic transmission, and the chemical signals involved in intercellular communication. Studies on the molecular and behavioral impact of genetic risk factors of human neuro-developmental disorders [autism spectrum disorders (ASDs), schizophrenia, attention deficit hyperactivity disorders, and Tourette syndrome] increasingly use the well-studied social behavior of D...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28727612/commentary-on-formula-feeding-as-a-risk-factor-for-attention-deficiency-hyperactivity-disorder-is-bisphenol-a-exposure-a-smoking-gun
#20
Michael Weitzman, Lily Lee
No abstract text is available yet for this article.
September 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
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