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attention deficiency hyperactivity disorder

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https://www.readbyqxmd.com/read/28336432/behavioral-abnormalities-and-reduced-norepinephrine-in-ep4-receptor-associated-protein-eprap-deficient-mice
#1
Risako Fujikawa, Sei Higuchi, Taichi Ikedo, Manabu Nagata, Kosuke Hayashi, Tao Yang, Takeshi Miyata, Masayuki Yokode, Manabu Minami
EP4 receptor-associated protein (EPRAP) is a newly identified molecule that regulates macrophage activation. We recently demonstrated the presence of EPRAP in the mice brain; however, little is known about the function of EPRAP in this tissue. Therefore, we investigated the role of EPRAP in behavior and emotion using behavioral analysis in mice. In this study, we subjected EPRAP-deficient (KO) mice and wild-type C57BL/6 (WT) mice to a battery of behavioral tests. EPRAP-KO mice tended to have shorter latencies to fall in the wire hang test, but had normal neuromuscular strength...
March 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28334461/profile-of-children-diagnosed-with-a-fetal-alcohol-spectrum-disorder-a-retrospective-chart-review
#2
Natasha Reid, Doug Shelton, Judith Warner, Frances O'Callaghan, Sharon Dawe
INTRODUCTION AND AIMS: Fetal alcohol spectrum disorder (FASD) is a significant public health concern, and growing recognition in Australia led to the establishment of a specialist service for young children. The aim of the current study was to report on the diagnostic profile of a group of children who attended the service, to document the extent to which there were comorbid diagnoses and to provide information on the neurocognitive functioning of the children. DESIGN AND METHODS: This study was a retrospective chart review conducted by the diagnostic service...
March 23, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28334053/new-insights-of-altered-lipid-profile-in-fragile-x-syndrome
#3
Artuela Çaku, Nabil G Seidah, Audrey Lortie, Nancy Gagné, Patrice Perron, Jean Dubé, Francois Corbin
BACKGROUND: Fragile X Syndrome (FXS) is the main genetic cause of autism and intellectual deficiency resulting the absence of the Fragile X Mental Retardation Protein (FMRP). Clinical picture is characterized by cognitive impairment associated with a broad spectrum of psychiatric comorbidities including autism spectrum disorders and attention-deficit/hyperactivity disorders. Some of these disorders have been associated with lipid abnormalities and lower cholesterol levels. Since lipids are important for neuronal development, we aim to investigate the lipid profile of French Canadian-FXS individuals and to identify the altered components of cholesterol metabolism as well as their association with clinical profile...
2017: PloS One
https://www.readbyqxmd.com/read/28319054/association-of-attention-deficit-hyperactivity-disorder-and-autism-spectrum-disorders-with-mean-platelet-volume-and-vitamin-d
#4
Mesut Garipardic, Murat Doğan, Keziban Asli Bala, Tuba Mutluer, Sultan Kaba, Oktay Aslan, Lokman Üstyol
BACKGROUND The purpose of this study was to assess the values of the mean platelet volume (MPV) in children with attention deficit hyperactivity disorder (ADHD) and with autism spectrum disorders (ASDs) to determine the risk of cardiovascular disease in these 2 disorder groups. MATERIAL AND METHODS The study included a total of 79 patients with ADHD or ASDs and controls in the Van region of Turkey. The control group included subjects of matching age and sex with no ADHD, ASDs, or chronic disease and taking no vitamins...
March 20, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28293481/a-genetic-variant-within-sts-previously-associated-with-inattention-in-boys-with-attention-deficit-hyperactivity-disorder-is-associated-with-enhanced-cognition-in-healthy-adult-males
#5
Trevor Humby, Amelia Fisher, Christopher Allen, Meghann Reynolds, Annette Hartman, Ina Giegling, Dan Rujescu, William Davies
INTRODUCTION: The enzyme steroid sulfatase (STS) converts sulfated steroids to their non-sulfated forms. Deficiency for this enzyme is associated with inattention but preserved response control. The polymorphism rs17268988 within the X-linked STS gene is associated with inattentive, but not other, symptoms in boys with attention deficit hyperactivity disorder (ADHD). METHODS: We initially tested whether rs17268988 genotype was associated with attention, response control, and underlying aspects of cognition, using questionnaires and neuropsychological tasks, in two independent cohorts of healthy adult males...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28271675/vitamin-d-deficiency-and-a-blunted-parathyroid-hormone-response-in-children-with-attention-deficit-hyperactivity-disorder
#6
Sibelnur Avcil, Pinar Uysal, Mustafa Yilmaz, Duygu Erge, Sevcan K Demirkaya, Esra Eren
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is the most frequently diagnosed neuropsychiatric disorder of childhood. The etiopathogenesis of ADHD has not been fully defined. Recent evidence has suggested a pathophysiological role of vitamin D deficiency in ADHD. In this study, we evaluated the serum levels of 25-hydroxy vitamin D (25(OH)D), parathyroid hormone (PTH), calcium (Ca), phosphate (P), and alkaline phosphatase (ALP) in children with ADHD. METHODS: The study group consisted of 105 children diagnosed with ADHD according to DSM-IV-TR criteria...
March 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28250422/components-of-the-folate-metabolic-pathway-and-adhd-core-traits-an-exploration-in-eastern-indian-probands
#7
Tanusree Saha, Mahasweta Chatterjee, Swagata Sinha, Usha Rajamma, Kanchan Mukhopadhyay
We investigated role of the folate-homocysteine metabolic pathway in the etiology of attention-deficit hyperactivity disorder (ADHD) due to its importance in maintaining DNA integrity as well as neurotransmission. Functional gene variants in MTR (rs1805087), CBS (rs5742905), MTHFR (rs1801133 & rs1801131), MTHFD (rs2236225), RFC1 (rs1051266), plasma vitamin B12, folate and homocysteine were analyzed. rs1805087 'A' showed strong association with ADHD. Vitamin B12 deficiency of ADHD probands (P=0.01) correlated with rs1801133 'T' and rs1805087'GG'...
March 2, 2017: Journal of Human Genetics
https://www.readbyqxmd.com/read/28225747/effect-of-methylphenidate-on-emotional-dysregulation-in-children-with-attention-deficit-hyperactivity-disorder-oppositional-defiant-disorder-conduct-disorder
#8
Ayse Kutlu, Ulku Akyol Ardic, Eyup Sabri Ercan
BACKGROUND AND AIM: Emotional dysregulation (ED) is a frequent feature of attention-deficit/hyperactivity disorder (ADHD). It can be observed as a dysregulation profile or a deficient emotional self-regulation (DESR) profile. Oppositional defiant disorder/conduct disorder (ODD/CD) comorbidity is prevalent in ADHD and known to be related with ED. The first-line treatment of ADHD includes psychostimulants, but their effects on ED are not well studied. This study aimed to evaluate the outcomes of methylphenidate (MPH) treatment on ED in ADHD + ODD/CD cases...
April 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28215238/sleep-disordered-breathing-in-children-with-cerebral-palsy
#9
Engin Koyuncu, Mustafa H Türkkani, Fatma G Sarikaya, Neşe Özgirgin
OBJECTIVES: The purpose of this study was to investigate the frequency of Sleep Disordered Breathing (SDB) in children with Cerebral Palsy (CP), and determine whether a relationship between SDB and age, gender, weight status, type of CP, motor function level, and spasticity can be established. METHODS: The study included 94 children with CP and 94 healthy children with normal development, between the ages two and 18. SDB was assessed using the Sleep-Related Breathing Disorder (SRBD) scale of the Pediatric Sleep Questionnaire (PSQ)...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28176434/network-level-assessment-of-reward-related-activation-in-patients-with-adhd-and-healthy-individuals
#10
Daniel von Rhein, Christian F Beckmann, Barbara Franke, Jaap Oosterlaan, Dirk J Heslenfeld, Pieter J Hoekstra, Catharina A Hartman, Marjolein Luman, Stephen V Faraone, Roshan Cools, Jan K Buitelaar, Maarten Mennes
INTRODUCTION: Reward processing is a key aspect of cognitive control processes, putatively instantiated by mesolimbic and mesocortical brain circuits. Deficient signaling within these circuits has been associated with psychopathology. We applied a network discovery approach to assess specific functional networks associated with reward processing in participants with attention-deficit/hyperactivity disorder (ADHD). METHODS: To describe task-related processes in terms of integrated functional networks, we applied independent component analysis (ICA) to task response maps of 60 healthy participants who performed a monetary incentive delay (MID) task...
February 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28168960/sex-specific-neurodevelopmental-programming-by-placental-insulin-receptors-on-stress-reactivity-and-sensorimotor-gating
#11
Stefanie L Bronson, Jennifer C Chan, Tracy L Bale
BACKGROUND: Diabetes, obesity, and overweight are prevalent pregnancy complications that predispose offspring to neurodevelopmental disorders, including autism, attention-deficit/hyperactivity disorder, and schizophrenia. Although male individuals are three to four times more likely than female individuals to develop these disorders, the mechanisms driving the sex specificity of disease vulnerability remain unclear. Because defective placental insulin receptor (InsR) signaling is a hallmark of pregnancy metabolic dysfunction, we hypothesized that it may be an important contributor and novel mechanistic link to sex-specific neurodevelopmental changes underlying disease risk...
December 30, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/28168597/the-role-of-nutritional-supplements-in-the-treatment-of-adhd-what-the-evidence-says
#12
REVIEW
Klaus W Lange, Joachim Hauser, Katharina M Lange, Ewelina Makulska-Gertruda, Yukiko Nakamura, Andreas Reissmann, Yuko Sakaue, Tomoyuki Takano, Yoshihiro Takeuchi
Attention-deficit hyperactivity disorder (ADHD) is a common behavioral disorder in children and adolescents and may persist into adulthood. Insufficient nutritional supply of long-chain polyunsaturated fatty acids (LC-PUFAs) and other components including various minerals has been suggested to play a role in the development of ADHD symptoms. This review presents the evidence regarding the role of nutritional PUFA, zinc, iron, and magnesium supplements in the treatment of ADHD with a focus on the critical evaluation of the relevant literature published from 2014 to April 2016...
February 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28142338/toxicity-assessment-of-molindone-hydrochloride-a-dopamine-d2-d5-receptor-antagonist-in-juvenile-and-adult-rats
#13
Gopala Krishna, Gopa Gopalakrishnan, Saryu Goel
Neuroleptic drug molindone hydrochloride is a dopamine D2/D5 receptor antagonist and it is in late stage development for the treatment of impulsive aggression in children and adolescents who have attention deficient/hyperactivity disorder (ADHD). This new indication for this drug would expand the target population to include younger patients, and therefore, toxicity assessments in juvenile animals were undertaken in order to determine susceptibility differences, if any, between this age group and the adult rats...
January 31, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28138007/the-mediterranean-diet-and-adhd-in-children-and-adolescents
#14
Alejandra Ríos-Hernández, José A Alda, Andreu Farran-Codina, Estrella Ferreira-García, Maria Izquierdo-Pulido
OBJECTIVES: Although attention-deficit/hyperactivity disorder (ADHD) has been related to nutrient deficiencies and "unhealthy" diets, to date there are no studies that examined the relationship between the Mediterranean diet and ADHD. We hypothesized that a low adherence to a Mediterranean diet would be positively associated with an increase in ADHD diagnosis. METHODS: A total of 120 children and adolescents (60 with newly diagnosed ADHD and 60 controls) were studied in a sex- and age-matched case-control study...
January 30, 2017: Pediatrics
https://www.readbyqxmd.com/read/28050211/auditory-processing-assessment-in-children-with-attention-deficit-hyperactivity-disorder-an-open-study-examining-methylphenidate-effects
#15
Bianca Pinheiro Lanzetta-Valdo, Giselle Alves de Oliveira, Jane Tagarro Correa Ferreira, Ester Miyuki Nakamura Palacios
Introduction Children with Attention Deficit Hyperactivity Disorder can present Auditory Processing (AP) Disorder. Objective The study examined the AP in ADHD children compared with non-ADHD children, and before and after 3 and 6 months of methylphenidate (MPH) treatment in ADHD children. Methods Drug-naive children diagnosed with ADHD combined subtype aging between 7 and 11 years, coming from public and private outpatient service or public and private school, and age-gender-matched non-ADHD children, participated in an open, non-randomized study from February 2013 to December 2013...
January 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28046016/iron-status-in-attention-deficit-hyperactivity-disorder-a-systematic-review-and-meta-analysis
#16
Yan Wang, Lan Huang, Li Zhang, Yi Qu, Dezhi Mu
BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is one of the most common psychiatric disorders in children. However, the pathogenesis of ADHD remains unclear. Iron, an important trace element, is implicated in brain function and dopaminergic activity. Recent studies have investigated the association between iron deficiency and ADHD, but the results are inconsistent. METHODS: A systemic search of MEDLINE, EMBASE, Web of Science and Cochrane Library databases was supplemented by manual searches of references of key retrieved articles...
2017: PloS One
https://www.readbyqxmd.com/read/28045139/chrna7-deficient-mice-manifest-no-consistent-neuropsychiatric-and-behavioral-phenotypes
#17
Jiani Yin, Wu Chen, Hongxing Yang, Mingshan Xue, Christian P Schaaf
The alpha7 nicotinic acetylcholine receptor, encoded by the CHRNA7 gene, has been implicated in various psychiatric and behavioral disorders, including schizophrenia, bipolar disorder, epilepsy, autism, Alzheimer's disease, and Parkinson's disease, and is considered a potential target for therapeutic intervention. 15q13.3 microdeletion syndrome is a rare genetic disorder, caused by submicroscopic deletions on chromosome 15q. CHRNA7 is the only gene in this locus that has been deleted entirely in cases involving the smallest microdeletions...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27943064/investigating-the-impact-of-cognitive-load-and-motivation-on-response-control-in-relation-to-delay-discounting-in-children-with-adhd
#18
Mary K Martinelli, Stewart H Mostofsky, Keri S Rosch
Attention-deficit/hyperactivity disorder (ADHD) is characterized by deficits in impulse control across a range of behaviors, from simple actions to those involving complex decision-making (e.g., preference for smaller-sooner versus larger later rewards). This study investigated whether changes in motor response control with increased cognitive load and motivational contingencies are associated with decision-making in the form of delay discounting among 8-12 year old children with and without ADHD. Children with ADHD (n = 26; 8 girls) and typically developing controls (n = 40; 11 girls) completed a standard go/no-go (GNG) task, a GNG task with motivational contingencies, a GNG task with increased cognitive load, and two measures of delay discounting: a real-time task in which the delays and immediately consumable rewards are experienced in real-time, and a classic task involving choices about money at longer delays...
December 12, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/27922243/late-diagnosed-phenylketonuria-in-an-eight-year-old-boy-with-dyslexia-and-attention-deficit-hyperactivity-disorder
#19
Yılmaz Yıldız, Ali Dursun, Ayşegül Tokatlı, Turgay Coşkun, Hatice Serap Sivri
Phenylketonuria, previously a common cause of severe intellectual disability, is a metabolic disorder now promptly diagnosed and effectively treated thanks to newborn screening programs. Here, we report a male patient presenting with dyslexia and attention-deficit hyperactivity disorder, who was diagnosed with mild phenylketonuria at eight years of age. Earlier recognition and treatment before the establishment of irreversible brain damage would have resulted in better neurobehavioural outcomes. Classical phenylketonuria and milder phenotypes of phenylalanine hydroxylase deficiency need to be considered in the differential diagnosis of all cognitive and behavioural problems of unknown cause...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27920735/lower-sensitivity-to-happy-and-angry-facial-emotions-in-young-adults-with-psychiatric-problems
#20
Charlotte Vrijen, Catharina A Hartman, Gerine M A Lodder, Maaike Verhagen, Peter de Jonge, Albertine J Oldehinkel
Many psychiatric problem domains have been associated with emotion-specific biases or general deficiencies in facial emotion identification. However, both within and between psychiatric problem domains, large variability exists in the types of emotion identification problems that were reported. Moreover, since the domain-specificity of the findings was often not addressed, it remains unclear whether patterns found for specific problem domains can be better explained by co-occurrence of other psychiatric problems or by more generic characteristics of psychopathology, for example, problem severity...
2016: Frontiers in Psychology
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