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https://www.readbyqxmd.com/read/29456560/the-effect-of-testosterone-gel-on-fertility-outcomes-in-women-with-a-poor-response-in-in-vitro-fertilization-cycles-a-pilot-randomized-clinical-trial
#1
Nasrin Saharkhiz, Shahrzad Zademodares, Saghar Salehpour, Sedighe Hosseini, Leyla Nazari, Hatav Ghasemi Tehrani
Background: In this study, the effect of testosterone gel administration during ovulation induction on the fertility rate was examined in women with a poor ovarian response in in vitro fertilization (IVF) cycles. Materials and Methods: The current study is a single-blinded, randomized clinical trial. Patients who met inclusion (Bologna) criteria were placed in the antagonist cycle group. The patients were randomly divided into two groups each included 25 participants treated with a placebo (lubricant gel, the controls) and testosterone gel (intervention)...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29416341/cognitive-behavioral-group-therapy-versus-psychoeducational-intervention-in-parkinson-s-disease
#2
Isabella Berardelli, Maria Carmela Bloise, Matteo Bologna, Antonella Conte, Maurizio Pompili, Dorian A Lamis, Massimo Pasquini, Giovanni Fabbrini
Objective: The aim of the current study was to evaluate whether cognitive behavioral group therapy has a positive impact on psychiatric, and motor and non-motor symptoms in Parkinson's disease (PD). Methods: We assigned 20 PD patients with a diagnosis of psychiatric disorder to either a 12-week cognitive behavioral therapy (CBT) group or a psychoeducational protocol. For the neurological examination, we administered the Unified Parkinson's Disease Rating Scale and the non-motor symptoms scale...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29405194/-the-significance-of-student-competitions-for-the-development-of-motivation-for-education-and-the-acquisition-of-professional-competences-in-the-students-the-department-of-forensic-medical-expertise-of-the-sechenovsky-university
#3
Yu I Pigolkin, Yu V Lomakin, E N Leonova
Russia joined the Bologna process in 2003 and since that time has become integrated into the unified European educational space. The key element of the new form of the higher education process is the self-guided unsupervised work of the students. Motivation is needed to promote the involvement of the students in the educational process which implies the necessity of the goal-oriented initiative for the acquisition of professional knowledge and practical experience in the field of forensic medicine. To achieve this goal, the Department of Forensic Medicine of I...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29405181/-the-synopsis-of-results-of-the-20-year-activities-of-the-department-of-forensic-medicine-i-m-sechenov-first-moscow-state-medical-university-sechenovsky-university
#4
Yu I Pigolkin, Yu V Lomakin, G V Zolotenkova, M A Shilova, I A Dubrovin, E N Leonova, A V Khodulapov
The present article was designed to summarize the results of the 20 year scientific, practical, and educational activities of the Department of Forensic Medicine, I.M. Sechenov First Moscow State Medical University (Sechenovsky University). The main directions of the research work and achievements of the Department's staff are described, and the prospects for its further development are highlighted. The new approaches to and technologies for the teaching and training specialists in forensic medicine are introduced to meet the novel requirements imposed in the framework of the ongoing reform of higher medical education in accordance with the main principles of the Bologna declaration...
2018: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/29400653/short-term-dual-antiplatelet-therapy-after-interventional-left-atrial-appendage-closure-with-different-devices
#5
Felix K Weise, Stefano Bordignon, Laura Perrotta, Athanasios Konstantinou, Fabrizio Bologna, Takahiko Nagase, Shaojie Chen, K R Julian Chun, Boris Schmidt
AIMS: We aimed to assess the feasibility, efficacy and safety of short-term dual antiplatelet therapy (DAPT) for 6 weeks after left atrial appendage closure (LAAC). METHODS AND RESULTS: Data of the Cardioangiologisches Centrum Bethanien-LAAC registry were analysed. DAPT (aspirin 100mg plus clopidogrel 75mg) was administered until transoesophageal echocardiography (TEE) evaluation 6 weeks after LAAC. In the absence of significant peri-device flow or device-related thrombus (DRT) the medication was decreased to single antiplatelet therapy (SAPT)...
February 6, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29398448/nucleo-cytosolic-shuttling-of-argonaute1-prompts-a-revised-model-of-the-plant-microrna-pathway
#6
Nicolas G Bologna, Raphael Iselin, Luciano A Abriata, Alexis Sarazin, Nathan Pumplin, Florence Jay, Thomas Grentzinger, Matteo Dal Peraro, Olivier Voinnet
Unlike in metazoans, plant microRNAs (miRNAs) undergo stepwise nuclear maturation before engaging cytosolic, sequence-complementary transcripts in association with the silencing effector protein ARGONAUTE1 (AGO1). Since their discovery, how and under which form plant miRNAs translocate to the cytosol has remained unclear, as has their sub-cellular AGO1 loading site(s). Here, we show that the N termini of all plant AGO1s contain a nuclear-localization (NLS) and nuclear-export signal (NES) that, in Arabidopsis thaliana (At), enables AtAGO1 nucleo-cytosolic shuttling in a Leptomycin-B-inhibited manner, diagnostic of CRM1(EXPO1)/NES-dependent nuclear export...
January 31, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29392445/correction-to-paragangliomas-arise-through-an-autonomous-vasculo-angio-neurogenic-program-inhibited-by-imatinib
#7
Fabio Verginelli, Silvia Perconti, Simone Vespa, Francesca Schiavi, Sampath Chandra Prasad, Paola Lanuti, Alessandro Cama, Lorenzo Tramontana, Diana Liberata Esposito, Simone Guarnieri, Artenca Sheu, Mattia Russel Pantalone, Rosalba Florio, Annalisa Morgano, Cosmo Rossi, Giuseppina Bologna, Marco Marchisio, Andrea D'Argenio, Elisa Taschin, Rosa Visone, Giuseppe Opocher, Angelo Veronese, Carlo T Paties, Vinagolu K Rajasekhar, Cecilia Söderberg-Nauclér, Mario Sanna, Lavinia Vittoria Lotti, Renato Mariani-Costantini
The given and family names of two co-authors were incorrect in the published article. The correct spelling should read as: Sampath Chandra Prasad and Vinagolu K Rajasekhar.
February 1, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29358003/predicting-device-failure-after-percutaneous-repair-of-functional-mitral-regurgitation-in-advanced-heart-failure-implications-for-patient-selection
#8
Davide Stolfo, Antonio De Luca, Gaetano Morea, Marco Merlo, Giancarlo Vitrella, Thomas Caiffa, Giulia Barbati, Serena Rakar, Renata Korcova, Andrea Perkan, Bruno Pinamonti, Aniello Pappalardo, Alessandra Berardini, Elena Biagini, Francesco Saia, Francesco Grigioni, Claudio Rapezzi, Gianfranco Sinagra
BACKGROUND: Patients with heart failure (HF) and severe symptomatic functional mitral regurgitation (FMR) may benefit from MitraClip implantation. With increasing numbers of patients being treated the success of procedure becomes a key issue. We sought to investigate the pre-procedural predictors of device failure in patients with advanced HF treated with MitraClip. METHODS: From April 2012 to November 2016, 76 patients with poor functional class (NYHA class III-IV) and severe left ventricular (LV) remodeling underwent MitraClip implantation at University Hospitals of Trieste and Bologna (Italy)...
January 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29356106/pigmented-fungiform-lingual-papillae-dermoscopic-and-clinical-features
#9
REVIEW
Marco Adriano Chessa, Annalisa Patrizi, Andrea Sechi, Annalucia Virdi, Miriam Leuzzi, Iria Neri
BACKGROUND: The tongue is covered by fungiform, filiform and circumvallate papillae. Fungiform papillae may be mainly pigmented in dark-skinned individuals. OBJECTIVE: A single-center study aimed to examine the clinical and dermoscopic features of pigmented fungiform papulae of the tongue (PFPT) in children, and a concise review of the literature has been performed. METHODS: The clinical and anamnestic data of 8 children affected by PFPT visited at the Pediatric Dermatology Unit of Bologna between 2010 and 2017, and a sistemic review of all studies of PFPT published on Pubmed up to August 31, 2017 have been collected and analyzed...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29347624/non-poisson-renewal-events-and-memory
#10
Rohisha Tuladhar, Mauro Bologna, Paolo Grigolini
We study two different forms of fluctuation-dissipation processes generating anomalous relaxations to equilibrium of an initial out-of-equilibrium condition, the former being based on a stationary although very slow correlation function and the latter characterized by the occurrence of crucial events, namely, non-Poisson renewal events, incompatible with the stationary condition. Both forms of regression to equilibrium have the same nonexponential Mittag-Leffler structure. We analyze the single trajectories of the two processes by recording the time distances between two consecutive origin recrossings and establishing the corresponding waiting time probability density function (PDF), ψ(t)...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346411/evaluation-of-hirst-type-spore-traps-in-outdoor-aspergillaceae-monitoring-during-large-demolition-work-in-hospital
#11
Sophie Tiphaine Loeffert, Philippe Vanhems, Estelle Tissot, Cédric Dananché, Pierre Cassier, Thomas Bénet, Michel Perraud, Michel Thibaudon, Marie-Paule Gustin
Demolition can generate fungal spore suspensions in association with various adverse health effects, such as high risk of invasive aspergillosis in immunocompromised patients. One block of Edouard Herriot Hospital was entirely demolished. The aim of the present study was to evaluate Hirst-type spore traps utility in monitoring outdoor Aspergillaceae (Aspergillus spp. + Penicillium spp.) spores in part of Edouard Herriot Hospital (Lyon, France) undergoing major demolition. Three periods were scheduled in 2015: (A) Gutting of building and asbestos removal, (B) Demolition of floors, (C) Excavation and earthwork...
2018: PloS One
https://www.readbyqxmd.com/read/29328804/replacement-of-the-nose
#12
Harold Ellis
Today's reconstructive surgeons may not be aware that replacement of the nose was carried out successfully as long ago as the 16th century by the surgeon Gaspar Taliacozzo of Bologna, Italy, who published a detailed and illustrated account of his operation in 1597. This procedure comprised raising a flap of skin from the upper arm to reconstruct the nose. The arm was kept in place, with the hand resting on the patient's head, using elaborate splinting until adherence had taken place; the flap was then detached from the donor arm...
May 2017: Journal of Perioperative Practice
https://www.readbyqxmd.com/read/29322493/the-struggle-for-via-bologna-street-market-crisis-racial-denial-and-speaking-back-to-power-in-naples-italy
#13
Antonia Dawes
This paper is based on ethnographic research conducted with migrant and Italian street vendors in Naples, southern Italy, in 2012. It tells the story of Via Bologna market which was nearly closed down by the City Hall at the time. Naples is a city where issues of poverty and unemployment pre-date and have been exacerbated by manifold narratives of crisis now unfolding across Europe regarding the economy, political legitimacy, security and migration. Street markets have always been an important and visible economic survival strategy for both Neapolitans and migrants there...
January 10, 2018: British Journal of Sociology
https://www.readbyqxmd.com/read/29317453/targeting-anticoagulant-protein-s-to-improve-hemostasis-in-hemophilia
#14
Raja Prince, Luca Bologna, Mirko Manetti, Daniela Melchiorre, Irene Rosa, Natacha Dewarrat, Silvia Suardi, Poorya Amini, José A Fernández, Laurent Burnier, Claudia Quarroz, Maria Desiré Reina Caro, Yasuhiro Matsumura, Johanna A Kremer Hovinga, John H Griffin, Hans-Uwe Simon, Lidia Ibba-Manneschi, François Saller, Sara Calzavarini, Anne Angelillo-Scherrer
Improved treatments are needed for hemophilia A and B, bleeding disorders affecting 400,000 people worldwide. We investigated whether targeting protein S could promote hemostasis in hemophilia by re-balancing coagulation. Protein S is an anticoagulant acting as cofactor for activated protein C and tissue factor pathway inhibitor (TFPI). This dual role makes PS a key regulator of thrombin generation. Here, we report that targeting protein S rebalances coagulation in hemophilia. Protein S gene targeting in hemophilic mice protected them against bleeding, especially when intra-articular...
January 9, 2018: Blood
https://www.readbyqxmd.com/read/29314832/oligonucleotide-peptide-complexes-phase-control-by-hybridization
#15
Jeffrey R Vieregg, Michael Lueckheide, Amanda Brittany Marciel, Lorraine Leon, Alex J Bologna, Josean Reyes Rivera, Matthew V Tirrell
When oppositely-charged polymers are mixed, counterion release drives phase separation; understanding this process is a key unsolved problem in polymer science and biophysical chemistry, particularly for nucleic acids, polyanions whose biological functions are intimately related to their high charge density. In the cell, complexation by basic proteins condenses DNA into chromatin, and membraneless organelles formed by liquid-liquid phase separation of RNA and proteins perform vital functions and have been linked to disease...
January 9, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29305721/paragangliomas-arise-through-an-autonomous-vasculo-angio-neurogenic-program-inhibited-by-imatinib
#16
Fabio Verginelli, Silvia Perconti, Simone Vespa, Francesca Schiavi, Sampath Chandra Prasat, Paola Lanuti, Alessandro Cama, Lorenzo Tramontana, Diana Liberata Esposito, Simone Guarnieri, Artenca Sheu, Mattia Russel Pantalone, Rosalba Florio, Annalisa Morgano, Cosmo Rossi, Giuseppina Bologna, Marco Marchisio, Andrea D'Argenio, Elisa Taschin, Rosa Visone, Giuseppe Opocher, Angelo Veronese, Carlo T Paties, Vinalogu K Rajasekhar, Cecilia Söderberg-Nauclér, Mario Sanna, Lavinia Vittoria Lotti, Renato Mariani-Costantini
Tumours can be viewed as aberrant tissues or organs sustained by tumorigenic stem-like cells that engage into dysregulated histo/organogenetic processes. Paragangliomas, prototypical organoid tumours constituted by dysmorphic variants of the vascular and neural tissues found in normal paraganglia, provide a model to test this hypothesis. To understand the origin of paragangliomas, we built a biobank comprising 77 cases, 18 primary cultures, 4 derived cell lines, 80 patient-derived xenografts and 11 cell-derived xenografts...
January 5, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29304467/vertical-variation-of-pm2-5-mass-and-chemical-composition-particle-size-distribution-no2-and-btex-at-a-high-rise-building
#17
Stefano Zauli Sajani, Stefano Marchesi, Arianna Trentini, Dimitri Bacco, Claudia Zigola, Sabrina Rovelli, Isabella Ricciardelli, Claudio Maccone, Paolo Lauriola, Domenico Maria Cavallo, Vanes Poluzzi, Andrea Cattaneo, Roy M Harrison
Substantial efforts have been made in recent years to investigate the horizontal variability of air pollutants at regional and urban scales and epidemiological studies have taken advantage of resulting improvements in exposure assessment. On the contrary, only a few studies have investigated the vertical variability and their results are not consistent. In this study, a field experiment has been conducted to evaluate the variation of concentrations of different particle metrics and gaseous pollutants on the basis of floor height at a high rise building...
January 2, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29297862/estimate-of-the-prevalence-of-subjects-with-gambling-related-problems-requiring-treatment-a-study-in-northern-italy
#18
Raimondo Maria Pavarin, Corrado Zenesini, Angelo Fioritti
This study analyzes the data related to subjects who for the first time turned to a hospital or to a Public Treatment Service Dedicated to Drug Addicts or to a Community Mental Health Center for problems related to pathological gambling in the metropolitan area of Bologna (Northern Italy) in the period 2000/2015. The aims were to describe characteristics and problems of pathological gamblers (PGs), and to estimate the prevalence of PGs using the capture-recapture method. Four hundred and ninety-five residents were identified, with an estimate of 1570 PGs and a prevalence of 1...
October 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/29280508/does-freeze-all-policy-affect-ivf-outcomes-in-poor-responders
#19
Matheus Roque, Marcello Valle, Marcos Sampaio, Selmo Geber
OBJECTIVES: To evaluate whether the freeze-all strategy affects in vitro fertilization (IVF) outcomes in poor ovarian responders following the Bologna criteria. METHODS: We performed a retrospective cohort study conducted between January 2012 and December 2016. A total of 433 poor responders (per the Bologna criteria) fulfilled the inclusion/exclusion criteria and were included in the study, with 277 patients included in the fresh group and 156 in the freeze-all group...
December 27, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29244762/towards-realistic-urban-traffic-experiments-using-dfrouter-heuristic-validation-and-extensions
#20
Jorge Luis Zambrano-Martinez, Carlos T Calafate, David Soler, Juan-Carlos Cano
Traffic congestion is an important problem faced by Intelligent Transportation Systems (ITS), requiring models that allow predicting the impact of different solutions on urban traffic flow. Such an approach typically requires the use of simulations, which should be as realistic as possible. However, achieving high degrees of realism can be complex when the actual traffic patterns, defined through an Origin/Destination (O-D) matrix for the vehicles in a city, remain unknown. Thus, the main contribution of this paper is a heuristic for improving traffic congestion modeling...
December 15, 2017: Sensors
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