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https://www.readbyqxmd.com/read/29224995/evaluation-of-alkylating-pyrrole-imidazole-polyamide-conjugates-by-a-novel-method-for-high-throughput-sequencer
#1
Gengo Kashiwazaki, Rina Maeda, Takashi Kawase, Kaori Hashiya, Toshikazu Bando, Hiroshi Sugiyama
N-Methylpyrrole-N-methylimidazole (PI) polyamides are a class of DNA minor groove binders with DNA sequence-specificity. DNA-alkylating PI polyamide conjugates are attractive candidates as anticancer drugs acting through DNA damage and its subsequent inhibition of cell proliferation. One example is a chlorambucil-PI polyamide conjugate targeting the runt-related transcription factor (RUNX) family. RUNX1 has pro-oncogenic properties in acute myeloid leukemia, and recently the chlorambucil-PI polyamide conjugate was demonstrated to have anticancer effects...
November 29, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29217279/wild-type-human-coronaviruses-prefer-cell-surface-tmprss2-to-endosomal-cathepsins-for-cell-entry
#2
Kazuya Shirato, Miyuki Kawase, Shutoku Matsuyama
Human coronaviruses (HCoVs) enter cells via two distinct pathways: the endosomal pathway using cathepsins to activate spike protein and the cell-surface or early endosome pathway using extracellular proteases such as transmembrane protease serine 2 (TMPRSS2). We previously reported that clinical isolates of HCoV-229E preferred cell-surface TMPRSS2 to endosomal cathepsin for cell entry, and that they acquired the ability to use cathepsin L by repeated passage in cultured cells and were then able to enter cells via the endosomal pathway...
December 4, 2017: Virology
https://www.readbyqxmd.com/read/29203079/residual-pressure-gradient-across-the-implanted-stent-an-important-factor-of-post-pci-physiological-results
#3
Yoshiaki Kawase, Masanori Kawasaki, Jun Kikuchi, Tetsuo Hirata, Syuuichi Okamoto, Toru Tanigaki, Hiroyuki Omori, Hideaki Ota, Munenori Okubo, Hiroki Kamiya, Akihiro Hirakawa, Hitoshi Matsuo
BACKGROUND: Instantaneous wave-free ratio (iFR) has the potential to improve the accuracy of the prediction of the physiological result of percutaneous coronary intervention (PCI). The aim of this study was to evaluate the accuracy of iFR to predict the final physiological results following PCI, and investigate the factors for failed prediction. METHODS: In 73 lesions, iFR pullback recordings were measured and comparisons were made between the predicted improvement following PCI and the observed result...
December 1, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/29201662/treatment-of-severe-mitral-regurgitation-caused-by-lesions-in-both-leaflets-using-multiple-mitral-valve-plasty-techniques-in-a-small-dog
#4
Satoko Yokoyama, Isamu Kanemoto, Kippei Mihara, Takanori Ando, Koudai Kawase, Yasuaki Sahashi, Kazuhito Iguchi
Mitral valve plasty (MVP) is preferred over mitral valve replacement (MVR) for mitral regurgitation in humans because of its favorable effect on quality of life. In small dogs, it is difficult to repair multiple lesions in both leaflets using MVP. Herein, we report a case of severe mitral regurgitation caused by multiple severe lesions in the posterior leaflet (PL) in a mixed Chihuahua. Initially, we had planned MVR with an artificial valve. However, MVP combined with artificial chordal reconstruction of both leaflets, semicircular suture annuloplasty, and valvuloplasty using a newly devised direct scallop suture for the PL was attempted in this dog...
2017: Open Veterinary Journal
https://www.readbyqxmd.com/read/29195381/in-situ-calibration-of-neutron-activation-system-on-the-large-helical-device
#5
N Pu, T Nishitani, M Isobe, K Ogawa, H Kawase, T Tanaka, S Y Li, S Yoshihashi, A Uritani
In situ calibration of the neutron activation system on the Large Helical Device (LHD) was performed by using an intense 252Cf neutron source. To simulate a ring-shaped neutron source, we installed a railway inside the LHD vacuum vessel and made a train loaded with the 252Cf source run along a typical magnetic axis position. Three activation capsules loaded with thirty pieces of indium foils stacked with total mass of approximately 18 g were prepared. Each capsule was irradiated over 15 h while the train was circulating...
November 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29193472/intellectual-disability-is-a-risk-factor-for-delayed-emergence-from-total-intravenous-anaesthesia
#6
H Higuchi, S Maeda, M Ishii-Maruhama, Y Honda-Wakasugi, A Yabuki-Kawase, T Miyawaki
BACKGROUND: Previous studies have suggested that ID influences the depth of general anaesthesia (GA) and delays emergence from GA. In this retrospective cohort study, we investigated whether ID affects the time taken to emerge from GA. METHODS: We selected dental patients who underwent GA at the Department of Dental Anaesthesiology, Okayama University Hospital, using predefined inclusion and exclusion criteria, before dividing the selected participants into ID and non-ID (control) groups...
November 29, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29191105/curcumin-and-its-derivatives-inhibit-2-3-7-8-tetrachloro-dibenzo-p-dioxin-induced-expression-of-drug-metabolizing-enzymes-through-aryl-hydrocarbon-receptor-mediated-pathway
#7
Rika Nakai, Shun Fukuda, Masaya Kawase, Yoko Yamashita, Hitoshi Ashida
Certain dioxins, including 2,3,7,8,-tetrachloro-dibenzo-p-dioxin (TCDD), are exogenous ligands for an aryl hydrocarbon receptor (AhR) and induces various drug-metabolizing enzymes. In this study, we examined the effect of curcumin on expression of drug-metabolizing enzymes through the AhR and NF-E2 related factor 2 (Nrf2) pathways. Curcumin dose-dependently inhibited TCDD-induced expression of phase I enzyme cytochrome P450 1A1 (CYP1A1) and phase II enzymes NAD(P)H:quinone oxidoreductase-1 (NQO1) and heme oxygenase 1 (HO-1) but not tert-butyl hydroquinone-induced NQO1 and HO-1, suggesting that curcumin inhibited only AhR pathway, but not Nrf2 one directly...
December 1, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/29187118/multifocal-human-papillomavirus-detection-in-palatine-and-pharyngeal-tonsils
#8
Shigeyuki Murono, Hiroshi Yoshida, Tetsuro Kobayashi, Tomotaka Kawase, Daisuke Kikuchi, Toshihiko Suzuki, Yosuke Nakanishi, Kazuhira Endo, Satoru Kondo, Naohiro Wakisaka, Tomokazu Yoshizaki
BACKGROUND: Multifocal human papillomavirus (HPV) infection into the palatine and pharyngeal tonsils, which might be linked to a second primary tumor of HPV-positive oropharyngeal cancer (OPC), was investigated. PATIENTS AND METHODS: One hundred and five patients with various head and neck diseases including 14 patients with OPC were enrolled in this study. Swabs from the palatine and pharyngeal tonsils were collected in each individual, and auto-nested GP5+/GP6+ PCR for HPV DNA was performed...
November 29, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29174986/correlation-between-glucuronidation-and-covalent-adducts-formation-with-proteins-of-nonsteroidal-anti-inflammatory-drugs
#9
Hiroaki Shimada, Yuri Kobayashi, Sakiko Tanahashi, Atsushi Kawase, Taro Ogiso, Masahiro Iwaki
Nonsteroidal anti-inflammatory drugs (NSAIDs) can cause idiosyncratic liver injury. Mechanisms involved in NSAID-induced liver injury are complex. Previous studies have suggested that acyl glucuronide of NSAIDs (NSAIDs-Glu) plays an important role in the development of liver injury via covalently binds to proteins and the resultant adduct induces immunological toxicity. As only some NSAIDs-Glu are commercially available, the evaluation of covalent protein adduct formation using ready-made NSAIDs-Glu is difficult and inconvenient...
November 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29169983/novel-proctorship-effectively-teaches-interventionists-coronary-artery-chronic-total-occlusion-lesions
#10
Masanori Yamamoto, Etsuo Tsuchikane, Ai Kagase, Tetsuro Shimura, Tomohiko Teramoto, Masashi Kimura, Hitoshi Matsuo, Yoshiaki Kawase, Yoriyasu Suzuki, Seiji Kano, Maoto Habara, Kenya Nasu, Yoshihisa Kinoshita, Mitsuyasu Terashima, Tetsuo Matsubara, Takahiko Suzuki
BACKGROUND: Interventionists' experience and skills are essential factors for successful chronic total occlusion-percutaneous coronary intervention (CTO-PCI). However, the construction of theoretical strategy independent from interventionists' procedure may also improve it. We sought to assess the feasibility of CTO-PCI using an educational system supported by a single expert proctor. METHODS: A total of 160 patients underwent CTO-PCI between 2009 and 2016 at 92 Japanese centers in the Hands-on proctorship project...
October 26, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29166176/microbiological-quality-assessment-of-game-meats-at-retail-in-japan
#11
Hiroshi Asakura, Jun Kawase, Tetsuya Ikeda, Mioko Honda, Yoshimasa Sasaki, Masashi Uema, Hidenori Kabeya, Hiromu Sugiyama, Shizunobu Igimi, Shinji Takai
In this study, we examined the prevalence of Shiga toxin-producing Escherichia coli and Salmonella spp. and the distribution of indicator bacteria in 248 samples of game meats (120 venison and 128 wild boar) retailed between November 2015 and March 2016 in Japan. No Salmonella spp. were detected in any of the samples, whereas Shiga toxin-producing Escherichia coli serotype OUT:H25 (stx2d(+), eae(-)) was isolated from one deer meat sample, suggesting a possible source for human infection. Plate count assays indicated greater prevalence of coliforms and E...
November 22, 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/29157413/incorporation-of-prosthetic-limbs-into-the-body-representation-of-amputees-evidence-from-the-crossed-hands-temporal-order-illusion
#12
Yuki Sato, Toshihiro Kawase, Kouji Takano, Charles Spence, Kenji Kansaku
Understanding how we consciously experience our bodies is a fundamental issue in both psychology and neuroscience. To date, the incorporation of nonbody objects into the body representation has been investigated extensively, and the incorporation of prosthetic arms in amputees has been demonstrated using the rubber hand illusion. In this study, we investigated the incorporation of prosthetic arms in amputees using the crossed hands illusion, in which successive somatosensory stimuli are delivered, one to each arm, at intervals of 300ms or less, and where arm crossing often causes inversion of perceived tactile temporal order...
2017: Progress in Brain Research
https://www.readbyqxmd.com/read/29151487/relationship-between-n-3-polyunsaturated-fatty-acids-and-extent-of-vessel-disease-in-patients-with-st-elevation-myocardial-infarction
#13
Takenobu Shimada, Kazushige Kadota, Haruki Eguchi, Kohei Osakada, Akimune Kuwayama, Masanobu Ohya, Katsuya Miura, Hidewo Amano, Shunsuke Kubo, Masatomo Ozaki, Yusuke Hyodo, Mitsuru Yoshino, Koshi Miyake, Yuichi Kawase, Noriyuki Ohashi, Suguru Otsuru, Hiroshi Tasaka, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Takeshi Maruo, Yasushi Fuku, Harumi Katoh, Satoki Fujii, Tsuyoshi Goto, Kazuaki Mitsudo
A relationship between serum polyunsaturated fatty acids (PUFAs) and cardiovascular disease has been reported; however, the existence of a relationship between serum PUFAs and extent of vessel disease (VD) in patients with ST elevation myocardial infarction (STEMI) remains unclear.Between July 2011 and June 2015, 866 consecutive STEMI patients underwent emergent percutaneous coronary intervention, 507 of whom were enrolled and classified into three groups according to the initial angiograms: 1VD, 294 patients; 2VD, 110 patients; and 3VD/left main trunk disease (LMTD), 103 patients...
November 17, 2017: International Heart Journal
https://www.readbyqxmd.com/read/29128884/effect-of-npt2b-deletion-on-intestinal-and-renal-inorganic-phosphate-pi-handling
#14
Kayo Ikuta, Hiroko Segawa, Shohei Sasaki, Ai Hanazaki, Toru Fujii, Aoi Kushi, Yuka Kawabata, Ruri Kirino, Sumire Sasaki, Miwa Noguchi, Ichiro Kaneko, Sawako Tatsumi, Otoya Ueda, Naoko A Wada, Hiromi Tateishi, Mami Kakefuda, Yosuke Kawase, Shuichi Ohtomo, Yasuhiro Ichida, Akira Maeda, Kou-Ichi Jishage, Naoshi Horiba, Ken-Ichi Miyamoto
BACKGROUND: Hyperphosphatemia is common in chronic kidney disease and is associated with morbidity and mortality. The intestinal Na(+)-dependent phosphate transporter Npt2b is thought to be an important molecular target for the prevention of hyperphosphatemia. The role of Npt2b in the net absorption of inorganic phosphate (Pi), however, is controversial. METHODS: In the present study, we made tamoxifen-inducible Npt2b conditional knockout (CKO) mice to analyze systemic Pi metabolism, including intestinal Pi absorption...
November 11, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29124407/educational-system-based-on-the-tapp-checklist-improves-the-performance-of-novices-a-multicenter-randomized-trial
#15
Saseem Poudel, Yo Kurashima, Kimitaka Tanaka, Hiroshi Kawase, Yoichi M Ito, Fumitaka Nakamura, Toshiaki Shichinohe, Satoshi Hirano
BACKGROUND: Despite recent developments in surgical education, obstacles including inadequate budget, limited human resources, and a scarcity of time have limited its widespread adoption. To provide systematic training for laparoscopic inguinal hernia repair, we had previously developed and validated a checklist to evaluate the recorded performance of transabdominal preperitoneal (TAPP) repair. We had also developed an educational system that included didactic materials based on the TAPP checklist and incorporated remote evaluation and feedback system...
November 9, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29116212/causes-of-death-in-patients-with-severe-aortic-stenosis-an-observational-study
#16
Eri Minamino-Muta, Takao Kato, Takeshi Morimoto, Tomohiko Taniguchi, Hiroki Shiomi, Kenji Nakatsuma, Shinichi Shirai, Kenji Ando, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Yuichi Kawase, Makoto Miyake, Chisato Izumi, Hirokazu Mitsuoka, Masashi Kato, Yutaka Hirano, Shintaro Matsuda, Kazuya Nagao, Tsukasa Inada, Tomoyuki Murakami, Yasuyo Takeuchi, Keiichiro Yamane, Mamoru Toyofuku, Mitsuru Ishii, Moriaki Inoko, Tomoyuki Ikeda, Akihiro Komasa, Eiji Tada, Katsuhisa Ishii, Kozo Hotta, Nobuya Higashitani, Toshikazu Jinnai, Yoshihiro Kato, Yasutaka Inuzuka, Chiyo Maeda, Yuko Morikami, Naritatsu Saito, Ryuzo Sakata, Kenji Minatoya, Takeshi Kimura
Whether patients with severe aortic stenosis (AS) die because of AS-related causes is an important issue for the management of these patients. We used data from CURRENT AS registry, a Japanese multicenter registry, to assess the causes of death in severe AS patients and to identify the factors associated with non-cardiac mortality. We enrolled 3815 consecutive patients with a median follow-up of 1176 days; the 1449 overall deaths comprised 802 (55.3%) from cardiac and 647 (44.7%) from non-cardiac causes. Heart failure (HF) (25...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29113716/plethysmography-variability-index-for-prediction-of-fluid-responsiveness-during-graded-haemorrhage-and-transfusion-in-sevoflurane-anaesthetized-mechanically-ventilated-dogs
#17
Yusuke Endo, Koudai Kawase, Taku Miyasho, Tadashi Sano, Kazuto Yamashita, William W Muir
OBJECTIVE: To examine the accuracy of plethysmography variability index (PVI) as a noninvasive indicator of fluid responsiveness in hypovolaemic dogs. STUDY DESIGN: Prospective experimental study. ANIMALS: Six adult healthy sevoflurane-anaesthetized Beagle dogs. METHODS: Dogs were anaesthetized with 1.3-fold their individual minimum alveolar concentration of sevoflurane. The lungs were mechanically ventilated after neuromuscular blockade with vecuronium bromide...
August 25, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29103252/-port-site-metastasis-of-an-urothelial-carcinoma-after-laparoscopic-nephroureterectomy-a-case-report
#18
Toru Yamada, Tomoki Taniguchi, Hiroto Kotaka, Kazutoshi Akita, Kota Kawase, Kunihiro Tsuchiya, Kenichiro Ishida, Mitsuhiro Taniguchi, Yoshito Takahashi
We report a case of ureteral carcinoma in which port site metastasis was found after a laparoscopic nephroureterectomy. The patient was a 77-year-old woman with a chiefcomplaint ofgross hematuria. A tumor was found in her left ureter by computed tomography (CT). The patient was diagnosed with a left ureter carcinoma with T2N0M0 or less. She underwent retroperitoneoscopic radical nephroureterectomy. The pathological diagnosis was an urothelial carcinoma, Grade 2, pT2Nx. She was carefully followed up without any adjuvant therapy...
October 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29098550/enteric-glial-dysfunction-evoked-by-apolipoprotein-e-deficiency-contributes-to-delayed-gastric-emptying
#19
Seiichiro Fukuhara, Tatsuhiro Masaoka, Soraya Nishimura, Masaya Nakamura, Juntaro Matsuzaki, Hitoshi Tsugawa, Sawako Miyoshi, Hideki Mori, Satoshi Kawase, Shinsuke Shibata, Hideyuki Okano, Takanori Kanai, Hidekazu Suzuki
BACKGROUND AND AIM: Diabetes is the main cause of gastroparesis accompanying decreased neuronal nitric oxide synthase (nNOS) in myenteric ganglia of the stomach. Decreased nNOS expression in the stomach also results from defects in apolipoprotein E (ApoE), which is secreted by astrocytes and has neuroprotective effects on the central nervous system. However, the roles of ApoE and enteric glial cells on gastric motility are uncertain. In this study, ApoE and enteric glial cell alterations in gastroparesis were investigated...
December 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29093317/rapid-and-accurate-diagnosis-based-on-real-time-pcr-cycle-threshold-value-for-the-identification-of-campylobacter-jejuni-asta-gene-positive-escherichia-coli-and-eae-gene-positive-e-coli
#20
Jun Kawase, Hiroshi Asakura, Morito Kurosaki, Hitoshi Oshiro, Yoshiki Etoh, Tetsuya Ikeda, Masanori Watahiki, Mitsuhiro Kameyama, Fumi Hayashi, Yuta Kawakami, Yoshiko Murakami, Yoshie Tsunomori
  We previously developed a multiplex real-time PCR assay (Rapid Foodborne Bacterial Screening 24 ver.5, RFBS24 ver.5) for simultaneous detection of 24 foodborne bacterial targets. Here, to overcome the discrepancy of the RFBS24 ver.5 and bacterial culture method (BC) results, we analyzed 246 human clinical samples from 49 gastroenteritis outbreaks by the RFBS24 ver.5 and evaluated the correlation between cycle threshold value (CT) of RFBS24 ver.5 and the BC results. The results showed that the RFBS24 ver...
October 31, 2017: Japanese Journal of Infectious Diseases
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