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https://www.readbyqxmd.com/read/27927688/stereoselective-pharmacokinetics-and-chiral-inversion-of-ibuprofen-in-adjuvant-induced-arthritic-rats
#1
Hiroyuki Ikuta, Atsushi Kawase, Masahiro Iwaki
2-Arylpropionic acid (2-APA) nonsteroidal anti-inflammatory drugs are commonly used in racemic mixtures (rac) for clinical use. 2-APA undergo unidirectional chiral inversion of the in vivo inactive R-enantiomer to the active S-enantiomer. Inflammation causes the reduction of metabolic activities of drug-metabolizing enzymes such as cytochrome P450 (CYP) and UDP-glucuronosyltransferase. However, it is unclear whether inflammation affects the stereoselective pharmacokinetics and chiral inversion of 2-APA such as ibuprofen (IB)...
December 7, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27916779/delay-in-the-provision-of-medication-by-a-pharmacy-outside-the-respiratory-outpatient-department
#2
Masataka Matsumoto, Sachiko Fujita, Miwa Kannen, Kaori Kawase, Kazumi Kaneshiro, Kiyonobu Takatsuki
  Respiratory medicine physicians prescribe many different kinds of medications depending on the specific patient. To examine an outside pharmacy's ability to meet the demand of our respiratory prescription services, we developed a questionnaire for all the patients who came to our outpatient department from November 1, 2015 to January 31, 2016. A total of 298 of 330 patients answered the questionnaire.   Overall, 169 patients mainly went to the pharmacy near our hospital, whereas 64 patients mainly went to another pharmacy...
December 5, 2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27913265/hearing-preservation-during-anterior-petrosectomy-the-cochlear-safety-line
#3
Xiaoming Guo, Halima Tabani, Dylan Griswold, Ali Tayebi Meybodi, Jose Juan Gonzalez Sanchez, Michael T Lawton, Arnau Benet
BACKGROUND: Identification and protection of the cochlea during anterior petrosectomy is key to prevent hearing loss. Currently, there is no optimal method to infer the position of the cochlea in relation to the Kawase quadrangle, therefore damage to the cochlea during anterior petrosectomy remains a substantial risk. OBJECTIVES: To identify and define landmarks available during anterior petrosectomy to locate the cochlea and prevent its damage. METHODS: Kawase approach was simulated in eleven specimens...
November 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27910054/direct-myocardial-injection-of-vectors
#4
Guillaume Bonnet, Kiyotake Ishikawa, Roger J Hajjar, Yoshiaki Kawase
Gene therapy holds great promise as a targeted treatment of cardiovascular diseases, which remain a major cause of morbidity and mortality in contemporary societies. Selection of the appropriate vector delivery method is critical for efficient transduction in the myocardium. Direct myocardial delivery is a feasible and effective method that has been shown to exhibit enhanced gene expression compared to coronary infusion and pericardial delivery. It is one of the most widely used gene transfer methods in both animal studies and clinical trials...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27909282/-coronary-artery-revascularization-with-v-composite-saphenous-veins-graft-in-a-bad-ascending-aorta-report-of-a-case
#5
Makoto Shirakawa, Yosuke Ishii, Yasuhiro Kawase, Shunichiro Sakamoto, Yasuo Miyagi, Tetsuro Morota, Takashi Nitta
A 77-year-old male with many comorbidities underwent off pump coronary artery bypass grafting. A severely atherosclerotic ascending aorta was revealed by preoperative computed tomography(CT) and epiaortic echography during operation. Therefore, V-composite saphenous vein grafting was adopted for non left anterior descending artery (LAD) coronary lesions in addition to left internal thoracic artery-left anterior descending artery bypass grafting. He was discharged with no complications and all grafts were confirmed to be patent by postoperative CT...
December 2016: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/27863346/a-diet-induced-sprague-dawley-rat-model-of-nonalcoholic-steatohepatitis-related-cirrhosis
#6
Mayuko Ichimura, Miki Masuzumi, Miku Kawase, Mika Sakaki, Shizuka Tamaru, Yasuo Nagata, Kazunari Tanaka, Kazuhito Suruga, Koichi Tsuneyama, Satoru Matsuda, Katsuhisa Omagari
Certain modified diets containing saturated fatty acids, cholesterol or fructose lead to the development of nonalcoholic steatohepatitis (NASH)-related fibrosis in rodents; however, progression to cirrhosis is rare. Experimental liver cirrhosis models have relied on genetic manipulation or administration of hepatotoxins. This study aimed to establish a reliable dietary model of NASH-related cirrhosis in a relatively short period. Male Sprague-Dawley rats (9 weeks of age) were randomly assigned to normal, high-fat (HF), or two types (1...
October 24, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27837028/asp5878-a-novel-inhibitor-of-fgfr-1-2-3-and-4-inhibits-the-growth-of-fgf19-expressing-hepatocellular-carcinoma
#7
Takashi Futami, Hidetsugu Okada, Rumi Kihara, Tatsuya Kawase, Ayako Nakayama, Tomoyuki Suzuki, Minoru Kameda, Nobuaki Shindoh, Tadashi Terasaka, Masaaki Hirano, Sadao Kuromitsu
Hepatocellular carcinoma is an aggressive cancer with poor prognosis. Fibroblast growth factor 19, a member of the fibroblast growth factor family, is a ligand for fibroblast growth factor receptor 4. Moreover, it plays a crucial role in the progression of hepatocellular carcinoma. ASP5878 is a novel inhibitor of fibroblast growth factor receptors 1, 2, 3, and 4 that is under development. It inhibits fibroblast growth factor receptor 4 kinase activity with an IC50 of 3.5 nmol/L. ASP5878 potently suppressed the growth of the fibroblast growth factor 19-expressing hepatocellular carcinoma cell lines Hep3B2...
November 11, 2016: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/27836712/application-of-substrate-depletion-assay-to-evaluation-of-cyp-isoforms-responsible-for-stereoselective-metabolism-of-carvedilol
#8
Masahiro Iwaki, Toshiro Niwa, Saya Bandoh, Megumi Itoh, Hitomi Hirose, Atsushi Kawase, Hiroshi Komura
To evaluate the relative contribution of cytochrome P450 (CYP) isoforms responsible for carvedilol (CAR) oxidation, enantioselective metabolism of CAR was investigated in human liver microsomes (HLMs) and recombinant human CYPs by using the substrate depletion assay. CYP2D6 exhibited the highest contribution to the metabolism of R-CAR, followed by CYP3A4, CYP1A2, and CYP2C9, whereas the metabolism of the S-enantiomer was mainly mediated by CYP1A2, followed by CYP2D6 and CYP3A4. In HLMs, metabolism of R- and S-CAR was markedly inhibited by quinidine; R-CAR metabolism (57-61% decrease) was more inhibited than S-CAR metabolism (37-43% decrease), and furafylline and ketoconazole almost equally inhibited metabolism of both enantiomers by 25-32% and 30-50%, respectively...
September 2, 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27830459/comparison-of-radial-brachial-and-femoral-accesses-using-hemostatic-devices-for-percutaneous-coronary-intervention
#9
Masaya Otsuka, Nobuo Shiode, Yasuhisa Nakao, Yuki Ikegami, Yusuke Kobayashi, Arinori Takeuchi, Ayako Harima, Tadanao Higaki, Kuniomi Oi, Kazuoki Dai, Tomoharu Kawase, Yasuharu Nakama, Kazuyoshi Suenari, Kenji Nishioka, Koyu Sakai, Yuji Shimatani, Yoshiko Masaoka, Ichiro Inoue
Some studies have suggested that radial access (RA) for percutaneous coronary intervention (PCI) reduces vascular complications and bleeding compared to femoral access (FA). The purpose of this study was to investigate the routine use of hemostatic devices and bleeding complications among RA, brachial access (BA), and FA. Between January 2015 and December 2015, 298 patients treated for PCI with RA were compared with 158 patients using BA and 206 patients using FA. The radial sheath was routinely removed with ADAPTY, the brachial sheath with BLEED SAFE, and the femoral sheath with Perclose ProGlide...
November 9, 2016: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/27815466/fluorinated-beta-diketo-phosphorus-ylides-are-novel-efflux-pump-inhibitors-in-bacteria
#10
Annamária Kincses, Ágnes Míra Szabó, Ryosuke Saijo, Genki Watanabe, Masami Kawase, Joseph Molnár, Gabriella Spengler
BACKGROUND: One of the most important resistance mechanisms in bacteria is the increased expression of multidrug efflux pumps. To combat efflux-related resistance, the development of new efflux pump inhibitors is essential. MATERIALS AND METHODS: Ten phosphorus ylides were compared based on their MDR-reverting activity in multidrug efflux pump system consisting of the subunits acridine-resistance proteins A and B (AcrA and AcrB) and the multidrug efflux pump outer membrane factor TolC (TolC) of Escherichia coli K-12 AG100 strain and its AcrAB-TolC-deleted strain...
November 2016: In Vivo
https://www.readbyqxmd.com/read/27782168/fluorescent-protein-tagging-of-endogenous-protein-in-brain-neurons-using-crispr-cas9-mediated-knock-in-and-in-utero-electroporation-techniques
#11
Takeshi Uemura, Takuma Mori, Taiga Kurihara, Shiori Kawase, Rie Koike, Michiru Satoga, Xueshan Cao, Xue Li, Toru Yanagawa, Takayuki Sakurai, Takayuki Shindo, Katsuhiko Tabuchi
Genome editing is a powerful technique for studying gene functions. CRISPR/Cas9-mediated gene knock-in has recently been applied to various cells and organisms. Here, we successfully knocked in an EGFP coding sequence at the site immediately after the first ATG codon of the β-actin gene in neurons in the brain by the combined use of the CRISPR/Cas9 system and in utero electroporation technique, resulting in the expression of the EGFP-tagged β-actin protein in cortical layer 2/3 pyramidal neurons. We detected EGFP fluorescence signals in the soma and neurites of EGFP knock-in neurons...
October 26, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27774827/stereoselective-hepatic-disposition-of-ibuprofen-in-the-perfused-liver-of-rat-with-adjuvant-induced-arthritis
#12
Misato Uraki, Atsushi Kawase, Masahiro Iwaki
1. The effects of adjuvant-induced arthritis (AA) on the stereoselective hepatic disposition and chiral inversion of "profens" have scarcely been investigated. Ibuprofen (IB) undergoes unidirectional chiral inversion from R-IB to S-IB and is metabolized to IB-glucuronide (IB-Glu). 2. We used an in situ perfused rat liver system to clarify the effects of inflammation on the metabolic activities and chiral inversion of IB without protein binding. 3. After dosing of R-IB, AA had minimal effect on the elimination of R-IB from the perfusate...
October 22, 2016: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/27774590/development-of-hemiacetal-esterified-levofloxacin-to-prevent-chelation-with-metal-containing-drugs
#13
Toru Otori, Sumio Matzno, Atushi Kawase, Masahiro Iwaki, Tetsutaro Kimachi, Keiji Nishiwaki, William C Figoni, Ryuta Tominaga, Mai Asahide, Mayumi Nishikata, Yoshikazu Ishii, Kenji Matsuyama
OBJECTIVES: To avoid the chelate formation between levofloxacin (LVFX) and aluminium hydroxide in gastrointestinal tract, an ethoxycarbonyl 1-ethyl hemiacetal ester of levofloxacin (LVFX-EHE) was synthesised as a prodrug. METHODS: The effects of aluminium hydroxide on the bioavailability of LVFX following oral administration of LVFX-EHE were investigated in rats. Furthermore, the effects of aluminium hydroxide on small intestinal absorption of LVFX and LVFX-EHE when subjected to a hydrolysis experiment using in situ everted gut sac were investigated, and the minimal inhibitory concentrations (MICs) of LVFX and LVFX-EHE for various intestinal bacteria were measured...
December 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27747711/growth-factor-and-pro-inflammatory-cytokine-contents-in-platelet-rich-plasma-prp-plasma-rich-in-growth-factors-prgf-advanced-platelet-rich-fibrin-a-prf-and-concentrated-growth-factors-cgf
#14
Hideo Masuki, Toshimitsu Okudera, Taisuke Watanebe, Masashi Suzuki, Kazuhiko Nishiyama, Hajime Okudera, Koh Nakata, Kohya Uematsu, Chen-Yao Su, Tomoyuki Kawase
BACKGROUND: The development of platelet-rich fibrin (PRF) drastically simplified the preparation procedure of platelet-concentrated biomaterials, such as platelet-rich plasma (PRP), and facilitated their clinical application. PRF's clinical effectiveness has often been demonstrated in pre-clinical and clinical studies; however, it is still controversial whether growth factors are significantly concentrated in PRF preparations to facilitate wound healing and tissue regeneration. To address this matter, we performed a comparative study of growth factor contents in PRP and its derivatives, such as advanced PRF (A-PRF) and concentrated growth factors (CGF)...
December 2016: Int J Implant Dent
https://www.readbyqxmd.com/read/27747653/in-vitro-immunological-and-biological-evaluations-of-the-angiogenic-potential-of-platelet-rich-fibrin-preparations-a-standardized-comparison-with-prp-preparations
#15
Mito Kobayashi, Tomoyuki Kawase, Kazuhiro Okuda, Larry F Wolff, Hiromasa Yoshie
BACKGROUND: Platelet-rich fibrin (PRF), a platelet-rich plasma (PRP) derivative mainly composed of fibrin networks, has been increasingly demonstrated to be effective in wound healing in clinical and pre-clinical animal studies. However, there has still been a concern that major growth factors may significantly be loss from PRF during its preparation through the slow clotting process. To address this concern, we compared the angiogenic potential of PRF and PRP by standardization of procedures based on volume ratios...
December 2015: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/27733646/clinical-isolates-of-human-coronavirus-229e-bypass-the-endosome-for-cell-entry
#16
Kazuya Shirato, Kazuhiko Kanou, Miyuki Kawase, Shutoku Matsuyama
: Human coronavirus 229E (HCoV-229E), a causative agent of the common cold, enters host cells via two distinct pathways: one is mediated by cell surface proteases, particularly transmembrane protease serine 2 (TMPRSS2), and the other by endosomal cathepsin L. Thus, specific inhibitors of these proteases block virus infection. However, it is unclear which of these pathways is actually utilized by HCoV-229E in the human respiratory tract. Here, we examined the mechanism of cell entry used by a pseudotyped virus bearing the HCoV-229E spike (S) protein in the presence/absence of protease inhibitors...
October 12, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27726493/hydroxyl-radical-generation-in-electro-fenton-process-with-a-gas-diffusion-electrode-linkages-with-electro-chemical-generation-of-hydrogen-peroxide-and-iron-redox-cycle
#17
Tomonori Yatagai, Yoshiko Ohkawa, Daichi Kubo, Yoshinori Kawase
The hydroxyl radical generation in an electro-Fenton process with a gas-diffusion electrode which is strongly linked with electro-chemical generation of hydrogen peroxide and iron redox cycle was studied. The OH radical generation subsequent to electro-chemical generations of H2O2 was examined under the constant potential in the range of Fe(2+) dosage from 0 to 1.0 mM. The amount of generated OH radical initially increased and gradually decreased after the maximum was reached. The initial rate of OH radical generation increased for the Fe(2+) dosage <0...
October 11, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27725429/validity-of-self-reported-periodontal-disease-questionnaire-among-pregnant-women
#18
Sakura Chiga, Takashi Ohba, Daisuke Tanoue, Hiromi Kawase, Takahiko Katoh, Hidetaka Katabuchi
OBJECTIVES: As part of the Kumamoto RAINBOW Project, a multifaceted implementation of the prevention of premature labor, we investigated pregnant women's oral health status and assessed the validity of a self-reported periodontal disease questionnaire. METHODS: We examined the oral health status of pregnant women and asked them for subjective descriptions of symptoms of periodontitis both in the first and the second half of their pregnancy in Kumamoto Prefecture from August 2012 to January 2014...
2016: Nihon Eiseigaku Zasshi. Japanese Journal of Hygiene
https://www.readbyqxmd.com/read/27723527/adsorption-capacities-of-poly-%C3%AE-glutamic-acid-and-its-sodium-salt-for-cesium-removal-from-radioactive-wastewaters
#19
Shigeki Sakamoto, Yoshinori Kawase
Cesium removal from radioactive wastewaters was examined using water-insoluble poly-γ-glutamic acid (γ-PGA) and water-soluble sodium salt form poly-γ-L-glutamic acid (γ-PGANa) as biosorbents. The maximum adsorption capacities at equilibrium of γ-PGA and γ-PGANa for Cs were 345 mg-Cs(g-γ-PGA)(-1) at pH 6.0 and 290 mg-Cs(g-γ-PGANa)(-1) at pH 9.0, respectively. At lower pH < pKa, the carboxyl groups of γ-PGA primarily remained in the protonated form and adsorption of Cs only slightly occurred. At higher pH > pKa, the adsorption of Cs was significantly facilitated due to ionization of carboxyl groups to carboxylate ion...
December 2016: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/27695537/comparison-of-computational-fluid-dynamics-findings-with-intraoperative-microscopy-findings-in-unruptured-intracranial-aneurysms-an-initial-analysis
#20
Sandeep Talari, Yoko Kato, Hanbing Shang, Yasuhiro Yamada, Kei Yamashiro, Daisuke Suyama, Tsukasa Kawase, Vladimir Balik, Wu Rile
CONTEXT: The increase in the detection of unruptured cerebral aneurysms has led to management dilemma. Prediction of risk based on the size of the aneurysm is not always accurate. There is no objective way of predicting rupture of aneurysm so far. Computational fluid dynamics (CFDs) was proposed as a tool to identify the rupture risk. AIMS: To know the correlation of CFD findings with intraoperative microscopic findings and to know the relevance of CFD in the prediction of rupture risk and in the management of unruptured intracranial aneurysms...
October 2016: Asian Journal of Neurosurgery
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