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https://www.readbyqxmd.com/read/28992665/-clinical-study-of-bladder-tamponade-at-takeda-hospital
#1
Tomoyuki Oida, Norio Kawase
This retrospective study examined bladder tamponade in 58 patients (male, n=36 ; female, n=22 ; average age, 78.5 years old) at Takeda Hospital between 2006 and 2016. Twenty-four of the patients were prescribed anticoagulants, and 18 had an indwelling urethral catheter. The underlying diseases comprised of cystitis (male, n=7; female, n=19), iatrogenic lower urinary tract injury (male, n=13), bladder neoplasms (male, n=6 ; female, n=1), prostatic hemorrhage (male, n=7), renal cell carcinoma (male, n=1 ; female, n=1), and bladder stone (male, n=2 ; female, n=1)...
September 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28984711/genomic-organization-of-tbk1-copy-number-variations-in-glaucoma-patients
#2
Adam P DeLuca, L M Alward Wallace, Jeffrey Liebmann, Robert Ritch, Kazuhide Kawase, Young H Kwon, Alan L Robin, Edwin M Stone, Todd E Scheetz, John H Fingert
BACKGROUND: Approximately 1% of normal tension glaucoma cases are caused by TANK binding kinase 1 (TBK1) gene duplications and triplications. However, the precise borders and orientation of these TBK1 gene copy number variations (CNVs) on chromosome 12 are unknown. METHODS: We determined the exact borders of TBK1 CNVs and the orientation of duplicated or triplicated DNA segments in five NTG patients with different TBK1 mutations using whole genome sequencing. RESULTS: Tandemly duplicated chromosome segments spanning the TBK1 gene were detected in four NTG patients, each with unique borders...
September 3, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28983946/human-papillomavirus-type-6-11-identified-in-an-epidermoid-cyst-of-the-scrotum
#3
Masaaki Kawase, Kiyofumi Egawa, Takaoki Ishiji, Hidemi Nakagawa
To date, epidermoid cysts associated with human papillomavirus (HPV) infection have been described mainly in palmoplantar locations, and have involved HPV types 60 and 57. In contrast, HPV-6/11 is a major cause of condyloma acuminatum. Here, we report the case of a healthy 31-year-old man who presented to our clinic with a 1-month history of a 1-cm, reddish-brown, cystic scrotal tumor with a punctum. The lesion was studied histologically, immunohistochemically and by DNA-DNAin situ hybridization. Histology revealed an epidermoid cyst with vacuolated keratinocytes with shrunken nuclei (koilocytes) in the cyst wall...
October 6, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28983235/affective-stimuli-for-an-auditory-p300-brain-computer-interface
#4
Akinari Onishi, Kouji Takano, Toshihiro Kawase, Hiroki Ora, Kenji Kansaku
Gaze-independent brain computer interfaces (BCIs) are a potential communication tool for persons with paralysis. This study applies affective auditory stimuli to investigate their effects using a P300 BCI. Fifteen able-bodied participants operated the P300 BCI, with positive and negative affective sounds (PA: a meowing cat sound, NA: a screaming cat sound). Permuted stimuli of the positive and negative affective sounds (permuted-PA, permuted-NA) were also used for comparison. Electroencephalography data was collected, and offline classification accuracies were compared...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28978897/serum-ca-125-level-after-neoadjuvant-chemotherapy-is-predictive-of-prognosis-and-debulking-surgery-outcomes-in-advanced-epithelial-ovarian-cancer
#5
Tomohiko Matsuhashi, Toshiyuki Takeshita, Akihito Yamamoto, Rieko Kawase, Takashi Yamada, Keisuke Kurose, Daisuke Doi, Katsuyuki Konnai, Ryo Onose, Hisamori Kato
Recently, neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS) has been recommended for selected patients with International Federation of Gynecology and Obstetrics (FIGO) stage III or IV disease and bulky tumors. The aim of this study was to evaluate associations between post-NACT serum CA 125 levels, surgical outcomes, and clinical outcomes in patients with advanced epithelial ovarian cancer. We retrospectively analyzed 107 patients with FIGO stage III or IV ovarian cancer who were treated with NACT-IDS at the Gynecology Department of Kanagawa Cancer Center between January 2001 and December 2012...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28958620/discovery-and-sar-of-a-novel-series-of-natriuretic-peptide-receptor-a-npr-a-agonists
#6
Takehiko Iwaki, Yuji Nakamura, Taisaku Tanaka, Yasuyuki Ogawa, Osamu Iwamoto, Yoshihiko Okamura, Yumi Kawase, Mayumi Furuya, Yoshiaki Oyama, Takahiro Nagayama
Novel thienopyrimidine compounds 2 and 3 were discovered from high-throughput screening as Natriuretic Peptide Receptor A (NPR-A) agonists. Scaffold hopping of a thienopyrimidine ring to a quinazoline ring, introduction of the basic functional group and optimization of the substituent on the 6-position of the benzene ring of quinazoline led to improved agonistic activity. We discovered compound 48, which showed potent agonistic activity for NPR-A with an EC50 value of 0.073μM, indicating 350-fold potency compared to the hit compound 3...
September 18, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28932547/does-lung-cancer-surgery-cause-circulating-tumor-cells-a-multicenter-prospective-study
#7
Noriyuki Matsutani, Noriyoshi Sawabata, Masafumi Yamaguchi, Tetsukan Woo, Yujin Kudo, Akikazu Kawase, Satoshi Shiono, Hisae Iinuma, Shigeki Morita, Masafumi Kawamura
BACKGROUND: Cancer relapse is caused by residual isolated tumor cells (ITCs) remaining in the body after surgery. It is speculated that surgical manipulation may cause circulating tumor cells (CTCs) which are the origin of ITCs in the body. The occurrence of CTCs in surgical patients with non-small cell lung cancer (NSCLC) has been shown in retrospective observation, but not prospectively, thus we conducted a multicenter prospective study regarding the occurrence of CTCs by surgical manipulation...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28927221/extended-middle-fossa-approach-with-anterior-petrosectomy-and-anterior-clinoidectomy-for-resection-of-spheno-cavernous-tentorial-meningioma-the-hakuba-kawase-dolenc-approach-3-dimensional-operative-video
#8
https://www.readbyqxmd.com/read/28926988/quality-assessment-of-platelet-rich-fibrin-like-matrix-prepared-from-whole-blood-samples-after-extended-storage
#9
Hideo Kawabata, Kazushige Isobe, Taisuke Watanabe, Toshimitsu Okudera, Masayuki Nakamura, Masashi Suzuki, Jietsu Ryu, Yutaka Kitamura, Hajime Okudera, Kazuhiro Okuda, Koh Nakata, Tomoyuki Kawase
The platelet-rich fibrin-like matrix (PRFM) is usually prepared onsite and immediately used for regenerative therapy. Nonetheless, to meet the clinical necessity of preserving the PRFM without quality deterioration, we developed a method for preparation of PRFMs from short-term-stored whole blood (WB) samples. In this study, to evaluate the practical expiration date of storage, we extended the storage time of WB samples from 2 to 7 days and assessed the quality of the resulting PRFMs. WB samples collected with acid-citrate-dextrose were stored with gentle agitation at ambient temperature...
September 18, 2017: Biomedicines
https://www.readbyqxmd.com/read/28921482/analysis-of-gender-based-differences-among-surgeons-in-japan-results-of-a-survey-conducted-by-the-japan-surgical-society-part-2-personal-life
#10
Kazumi Kawase, Kyoko Nomura, Ryuji Tominaga, Hirotaka Iwase, Tomoko Ogawa, Ikuko Shibasaki, Mitsuo Shimada, Tomoaki Taguchi, Emiko Takeshita, Yasuko Tomizawa, Sachiyo Nomura, Kazuhiro Hanazaki, Tomoko Hanashi, Hiroko Yamashita, Norihiro Kokudo, Kotaro Maeda
PURPOSE: To assess the true conditions and perceptions of the personal lives of men and women working as surgeons in Japan. METHODS: In 2014, all e-mail subscribed members of the Japan Surgical Society (JSS, n = 29,861) were invited to complete a web-based survey. The questions covered demographic information, work environment, and personal life (including marital status, childcare, and nursing care for adult family members). RESULTS: In total, 6211 surgeons (5586 men and 625 women) returned the questionnaires, representing a response rate of 20...
September 18, 2017: Surgery Today
https://www.readbyqxmd.com/read/28916607/cauliflower-like-appearance-of-calcified-nodules-observed-by-coronary-angioscopy
#11
Kazuoki Dai, Kazuki Suruga, Yasuhisa Nakao, Yusuke Kobayashi, Yuki Ikegami, Hajime Takemoto, Tadanao Higaki, Kuniomi Oi, Tomoharu Kawase, Yasuharu Nakama, Kazuyoshi Suenari, Kenji Nishioka, Koyu Sakai, Masaya Otsuka, Yuji Shimatani, Yoshiko Masaoka, Nobuo Shiode
No abstract text is available yet for this article.
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28900188/decoding-finger-movement-in-humans-using-synergy-of-eeg-cortical-current-signals
#12
Natsue Yoshimura, Hayato Tsuda, Toshihiro Kawase, Hiroyuki Kambara, Yasuharu Koike
The synchronized activity of neuronal populations across multiple distant brain areas may reflect coordinated interactions of large-scale brain networks. Currently, there is no established method to investigate the temporal transitions between these large-scale networks that would allow, for example, to decode finger movements. Here we applied a matrix factorization method employing principal component and temporal independent component analyses to identify brain activity synchronizations. In accordance with previous studies investigating "muscle synergies", we refer to this activity as "brain activity synergy"...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28880712/the-efficacy-of-the-eustachian-tube-dysfunction-questionnaire-etdq-7-for-patulous-eustachian-tube-patient
#13
Ryoukichi Ikeda, Toshiaki Kikuchi, Hiromitsu Miyazaki, Hiroshi Hidaka, Tetsuaki Kawase, Yukio Katori, Toshimitsu Kobayashi
OBJECTIVE: To assess the efficacy of the Eustachian Tube Dysfunction Questionnaire (ETDQ-7) for patulous Eustachian tube (PET) patients. METHODS: A prospective survey of medical records identified 36 patients and 47 ears with PET, and 15 patients and 15 ears as control. The ETDQ-7, patulous Eustachian tube handicap inventory-10 (PHI-10) and Likert scale were evaluated. PET patients were divided into two groups based on severity of symptoms using the PHI score. RESULTS: The Cronbach α value of the PET group was 0...
September 7, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28861755/clarithromycin-decreases-rhinovirus-replication-and-cytokine-production-in-nasal-epithelial-cells-from-subjects-with-bronchial-asthma-effects-on-il-6-il-8-and-il-33
#14
Mutsuo Yamaya, Kazuhiro Nomura, Kazuya Arakawa, Mitsuru Sugawara, Xue Deng, Nadine Lusamba Kalonji, Hidekazu Nishimura, Mitsuhiro Yamada, Ryoichi Nagatomi, Tetsuaki Kawase
Rhinoviral infection is associated with an increased risk of asthma attacks. The macrolide clarithromycin decreases cytokine production in nasopharyngeal aspirates from patients with wheezing, but the effects of macrolides on cytokine production in nasal epithelial cells obtained from asthmatic subjects remain unclear. Here, human nasal epithelial cells were infected with type-14 rhinovirus (RV14), a major RV group. Titers and RNA of RV14 and cytokine concentrations, including IL-1β and IL-6, were higher in the supernatants of the cells obtained from subjects with bronchial asthma (asthmatic group) than in those from the non-asthmatic group...
August 31, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28832686/additive-effects-of-genetic-variants-associated-with-intraocular-pressure-in-primary-open-angle-glaucoma
#15
Fumihiko Mabuchi, Nakako Mabuchi, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Hiroyuki Iijima, Zentaro Yamagata, Mitsuko Takamoto, Makoto Aihara, Takeshi Iwata, Kazuhide Kawase, Yukihiro Shiga, Koji M Nishiguchi, Toru Nakazawa, Mineo Ozaki, Makoto Araie
To investigate the association between the additive effects of genetic variants associated with intraocular pressure (IOP) and IOP, vertical cup-to-disc ratio (VCDR), and high tension glaucoma (HTG) or normal tension glaucoma (NTG) as phenotypic features of primary open-angle glaucoma (POAG), and to evaluate the clinical usefulness of the additive effects of IOP-related genetic variants for predicting IOP elevation, Japanese patients with HTG (n = 255) and NTG (n = 261) and 246 control subjects were genotyped for nine IOP-related genetic variants near CAV2, GAS7, GLCCI1/ICA1, ABCA1, ARHGEF12, FAM125B, FNDC3B, ABO, and PTPRJ/AGBL2...
2017: PloS One
https://www.readbyqxmd.com/read/28826912/edaravone-is-a-candidate-agent-for-spinal-muscular-atrophy-in-vitro-analysis-using-a-human-induced-pluripotent-stem-cells-derived-disease-model
#16
Shiori Ando, Michinori Funato, Kazuki Ohuchi, Tsubasa Kameyama, Satoshi Inagaki, Junko Seki, Chizuru Kawase, Kazuhiro Tsuruma, Masamitsu Shimazawa, Hideo Kaneko, Hideaki Hara
Spinal muscular atrophy (SMA) is an intractable disease characterized by a progressive loss of spinal motor neurons, which leads to skeletal muscle weakness and atrophy. Currently, there are no curative agents for SMA, although it is understood to be caused by reduced levels of survival motor neuron (SMN) protein. Additionally, why reduced SMN protein level results in selective apoptosis in spinal motor neurons is still not understood. Our purpose in this study was to evaluate the therapeutic potential of edaravone, a free radical scavenger, by using induced pluripotent stem cells from an SMA patient (SMA-iPSCs) and to address oxidative stress-induced apoptosis in spinal motor neurons...
November 5, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28809469/electrostatic-polysulfides-confinement-to-inhibit-redox-shuttle-process-in-the-lithium-sulfur-batteries
#17
Min Ling, Wenjun Yan, Ayako Kawase, Hui Zhao, Yanbao Fu, Vincent S Battaglia, Gao Liu
Cationic polymer can capture polysulfide ions and inhibit polysulfide shuttle effect in lithium sulfur (Li-S) rechargeable batteries, enhancing the Li-S battery cycling performance. The cationic poly[bis(2-chloroethyl) ether-alt-1,3-bis[3-(dimethylamino) propyl]urea] quaternized (PQ) with a high density quaternary ammonium cations can trap the lithium polysulfide through the electrostatic attraction between positively charged quaternary ammonium (R4N(+)) and negatively charged polysulfide (Sx(2-)). PQ binder based sulfur electrodes deliver much higher capacity and provide better stability than traditional polyvinylidene fluoride (PVDF) binder based electrodes in Li-S cells...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28798977/risperidone-and-aripiprazole-alleviate-prenatal-valproic-acid-induced-abnormalities-in-behaviors-and-dendritic-spine-density-in-mice
#18
Yuta Hara, Yukio Ago, Atsuki Taruta, Shigeru Hasebe, Haruki Kawase, Wataru Tanabe, Shinji Tsukada, Takanobu Nakazawa, Hitoshi Hashimoto, Toshio Matsuda, Kazuhiro Takuma
RATIONALE: Rodents exposed prenatally to valproic acid (VPA) exhibit autism spectrum disorder (ASD)-like behavioral abnormalities. We recently found that prenatal VPA exposure causes hypofunction of the prefrontal dopaminergic system in mice. This suggests that the dopaminergic system may be a potential pharmacological target for treatment of behavioral abnormalities in ASD patients. OBJECTIVES: In the present study, we examined the effects of antipsychotic drugs, which affect the dopaminergic system, on the social interaction deficits, recognition memory impairment, and reduction in dendritic spine density in the VPA mouse model of ASD...
August 10, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28772047/kyoto-congestive-heart-failure-kchf-study-rationale-and-design
#19
Erika Yamamoto, Takao Kato, Neiko Ozasa, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Takeshi Kitai, Takeshi Morimoto, Ryoji Taniguchi, Moritake Iguchi, Masashi Kato, Mamoru Takahashi, Toshikazu Jinnai, Tomoyuki Ikeda, Kazuya Nagao, Takafumi Kawai, Akihiro Komasa, Ryusuke Nishikawa, Yuichi Kawase, Takashi Morinaga, Tsuneaki Kawashima, Yasuyo Motohashi, Mitsunori Kawato, Mamoru Toyofuku, Yukihito Sato, Koichiro Kuwahara, Tetsuo Shioi, Takeshi Kimura
AIMS: Over the last decade, major developments in medicine have led to significant changes in the clinical management of heart failure patients. This study was designed to evaluate the recent trends in clinical characteristics, management, and short-term and long-term prognosis of patients with acute decompensated heart failure (ADHF) in Japan. METHODS AND RESULTS: The Kyoto Congestive Heart Failure study is a prospective, observational, multicentre cohort study, enrolling consecutive ADHF patients from 19 participating hospitals in Japan from November 2014 to March 2016...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28766928/unusual-passivation-ability-of-superconcentrated-electrolytes-toward-hard-carbon-negative-electrodes-in-sodium-ion-batteries
#20
Koji Takada, Yuki Yamada, Eriko Watanabe, Jianhui Wang, Keitaro Sodeyama, Yoshitaka Tateyama, Kazuhisa Hirata, Takeo Kawase, Atsuo Yamada
The passivation of negative electrodes is key to achieving prolonged charge-discharge cycling with Na-ion batteries. Here, we report the unusual passivation ability of superconcentrated Na-salt electrolytes. For example, a 50 mol % sodium bis(fluorosulfonyl)amide (NaFSA)/succinonitrile (SN) electrolyte enables highly reversible Na(+) insertion into a hard carbon negative electrode without any electrolyte additive, functional binder, or electrode pretreatment. Importantly, an anion-derived passivation film is formed via preferential reduction of the anion upon charging, which can effectively suppress further electrolyte reduction...
October 4, 2017: ACS Applied Materials & Interfaces
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