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https://www.readbyqxmd.com/read/28226330/nutritional-recovery-after-open-and-laparoscopic-distal-gastrectomy-for-early-gastric-cancer-a-prospective-multicenter-comparative-trial-ccog1204
#1
Hidenobu Matsushita, Chie Tanaka, Kenta Murotani, Kazunari Misawa, Seiji Ito, Yuichi Ito, Mitsuro Kanda, Yoshinari Mochizuki, Kiyoshi Ishigure, Toyohisa Yaguchi, Jin Teramoto, Hiroshi Nakayama, Yoshihisa Kawase, Michitaka Fujiwara, Yasuhiro Kodera
BACKGROUND: Little information from prospective clinical trials is available on the influences of surgical approaches on postoperative body compositions and nutritional status. We designed a prospective non-randomized trial to compare postoperative chronological changes in body composition and nutritional status between laparoscopic and open distal gastrectomy for stage I gastric cancer (GC). METHODS: Body compositions and nutritional indicators in blood tests were measured at the baseline and at the 1st, 3rd, 6th, and 12th postoperative months (POM)...
February 23, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28223248/endoscopic-intradural-subtemporal-keyhole-approach-with-neuronavigational-assistance-to-the-suprasellar-petroclival-and-ventrolateral-brainstem-regions-an-anatomic-study
#2
Zhemin Ding, Qing Wang, Xiaojie Lu, Xinwei Qian
OBJECTIVE: The purposes of this study were to evaluate the feasibility of a purely endoscopic intradural approach to the suprasellar, petroclival and ventrolateral brainstem regions through a subtemporal keyhole and to assess the value of neuronavigational assistance in the Kawase approach. METHODS: Twenty endoscopic intradural subtemporal keyhole approaches were performed on 10 cadaveric heads. An intradural Kawase approach and a navigation-assisted intradural Kawase approach were then carried out on a random side of each specimen...
February 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28222973/nationwide-multi-institutional-retrospective-analysis-of-high-dose-rate-brachytherapy-combined-with-external-beam-radiotherapy-for-localized-prostate-cancer-an-asian-prostate-hdr-bt-consortium
#3
Hiromichi Ishiyama, Nobuhiko Kamitani, Hidemasa Kawamura, Shingo Kato, Manabu Aoki, Shinji Kariya, Taisei Matsumura, Motoki Kaidu, Ken Yoshida, Yaichiro Hashimoto, Yasutaka Noda, Keith H C Lim, Takatsugu Kawase, Takeo Takahashi, Koji Inaba, Motoyasu Kumano, Nobuhiko Yoshikawa, Yasuo Yoshioka, Katsumasa Nakamura, Junichi Hiratsuka, Jun Itami, Kazushige Hayakawa
PURPOSE: To report outcomes and risk factors of high-dose-rate (HDR) brachytherapy combined with external beam radiotherapy with or without androgen deprivation therapy (ADT) in prostate cancer patients. MATERIALS AND METHODS: This multi-institutional retrospective analysis comprised 3424 patients with localized prostate cancer at 16 Asian hospitals. One-thirds (27.7%) of patients received only neoadjuvant ADT, whereas almost half (49.5%) of patients received both neoadjuvant and adjuvant ADT...
February 17, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28218710/substitution-at-the-c-3-position-of-catechins-has-an-influence-on-the-binding-affinities-against-serum-albumin
#4
Masaki Ikeda, Manabu Ueda-Wakagi, Kaori Hayashibara, Rei Kitano, Masaya Kawase, Kunihiro Kaihatsu, Nobuo Kato, Yoshitomo Suhara, Naomi Osakabe, Hitoshi Ashida
It is known that catechins interact with the tryptophan (Trp) residue at the drug-binding site of serum albumin. In this study, we used catechin derivatives to investigate which position of the catechin structure strongly influences the binding affinity against bovine serum albumin (BSA) and human serum albumin (HSA). A docking simulation showed that (-)-epigallocatechin gallate (EGCg) interacted with both Trp residues of BSA (one at drug-binding site I and the other on the molecular surface), mainly by π-π stacking...
February 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28179592/five-year-clinical-outcome-of-asymptomatic-vs-symptomatic-severe-aortic-stenosis-after-aortic-valve-replacement
#5
Shinichi Shirai, Tomohiko Taniguchi, Takeshi Morimoto, Kenji Ando, Kengo Korai, Kenji Minakata, Michiya Hanyu, Fumio Yamazaki, Tadaaki Koyama, Tatsuhiko Komiya, Norio Kanamori, Koichiro Murata, Takeshi Kitai, Yuichi Kawase, Chisato Izumi, Tsukasa Inada, Eri Minamino-Muta, Takao Kato, Moriaki Inoko, Katsuhisa Ishii, Naritatsu Saito, Kazuo Yamanaka, Noboru Nishiwaki, Hiroyuki Nakajima, Toshihiko Saga, Shogo Nakayama, Genichi Sakaguchi, Atsushi Iwakura, Kotaro Shiraga, Koji Ueyama, Keiichi Fujiwara, Senri Miwa, Junichiro Nishizawa, Mitsuru Kitano, Hitoshi Kitayama, Ryuzo Sakata, Takeshi Kimura
BACKGROUND: There is discordance regarding the effect of symptom status before aortic valve replacement (AVR) on long-term outcome after AVR in severe aortic stenosis (AS).Methods and Results:The CURRENT AS registry is a multicenter retrospective registry enrolling 3,815 consecutive patients with severe AS. Among 1,196 patients managed with the initial AVR strategy, long-term clinical outcomes were compared between the symptomatic patients (n=905), and asymptomatic patients (n=291)...
February 9, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28157491/intravenous-dexamethasone-administration-before-orthognathic-surgery-reduces-the-postoperative-edema-of-the-masseter-muscle-a-randomized-controlled-trial
#6
Harutsugi Abukawa, Takashi Ogawa, Michihide Kono, Toshiyuki Koizumi, Yoko Kawase-Koga, Daichi Chikazu
PURPOSE: Dexamethasone seems to suppress postoperative swelling. However, the standard administration dose of dexamethasone for bilateral sagittal split osteotomy (BSSO) has not been reported. This study focused on clarifying the most effective dose of dexamethasone for BSSO. MATERIALS AND METHODS: This research was planned as a prospective, randomized controlled, double-blind study. Patients undergoing BSSO were randomly assigned to receive intravenous preoperative dexamethasone under 3 different dose conditions: 16 mg, 8 mg, and 0 mg (control)...
January 9, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28154267/contrast-induced-hyperemia-as-an-alternative-to-drug-induced-hyperemia-in-the-evaluation-of-the-fractional-flow-reserve-in-coronary-lesions
#7
Nobuo Shiode, Tomokazu Okimoto, Hiromichi Tamekiyo, Tomoharu Kawase, Kenichi Yamane, Yuzo Kagawa, Yuto Fujii, Yusuke Ueda, Naoya Hironobe, Yasuko Kato, Yasuhiko Hayashi
Objective Measuring the fractional flow reserve (FFR) requires the induction of coronary hyperemia, usually with adenosine, adenosine triphosphate (ATP), or papaverine. However, adenosine can induce rhythmic complications, and intracoronary boluses of papaverine that prolong the QT interval can cause ventricular tachycardia. Injection of contrast media, which is routinely performed to validate the FFR guidewire placement, also induces hyperemia and may be an alternative method of measuring the FFR. We evaluated the diagnostic accuracy of the FFR after contrast hyperemia (FFRcont) compared to FFR evaluated after intracoronary papaverine (FFRpp)...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28145466/effects-of-normothermic-conditioned-microwave-irradiation-on-cultured-cells-using-an-irradiation-system-with-semiconductor-oscillator-and-thermo-regulatory-applicator
#8
Mamiko Asano, Minoru Sakaguchi, Satoshi Tanaka, Keiichiro Kashimura, Tomohiko Mitani, Masaya Kawase, Hitoshi Matsumura, Takako Yamaguchi, Yoshikazu Fujita, Katsuyoshi Tabuse
We investigated the effects of microwave irradiation under normothermic conditions on cultured cells. For this study, we developed an irradiation system constituted with semiconductor microwave oscillator (2.45 GHz) and thermos-regulatory applicator, which could irradiate microwaves at varied output powers to maintain the temperature of cultured cells at 37 °C. Seven out of eight types of cultured cells were killed by microwave irradiation, where four were not affected by thermal treatment at 42.5 °C...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28141836/effects-of-visual-speech-on-early-auditory-evoked-fields-from-the-viewpoint-of-individual-variance
#9
Izumi Yahata, Tetsuaki Kawase, Akitake Kanno, Hiroshi Hidaka, Shuichi Sakamoto, Nobukazu Nakasato, Ryuta Kawashima, Yukio Katori
The effects of visual speech (the moving image of the speaker's face uttering speech sound) on early auditory evoked fields (AEFs) were examined using a helmet-shaped magnetoencephalography system in 12 healthy volunteers (9 males, mean age 35.5 years). AEFs (N100m) in response to the monosyllabic sound /be/ were recorded and analyzed under three different visual stimulus conditions, the moving image of the same speaker's face uttering /be/ (congruent visual stimuli) or uttering /ge/ (incongruent visual stimuli), and visual noise (still image processed from speaker's face using a strong Gaussian filter: control condition)...
2017: PloS One
https://www.readbyqxmd.com/read/28138885/removal-of-anionic-surfactant-sodium-dodecyl-benzene-sulfonate-sdbs-from-wastewaters-by-zero-valent-iron-zvi-predominant-removal-mechanism-for-effective-sdbs-removal
#10
Akari Takayanagi, Maki Kobayashi, Yoshinori Kawase
Mechanisms for removal of anionic surfactant sodium dodecyl benzene sulfonate (SDBS) in wastewaters by zero-valent iron (ZVI) were systematically examined. The contributions of four removal mechanisms, i.e., reductive degradation, oxidative degradation, adsorption, and precipitation, changed significantly with solution pH were quantified and the effective removal of SDBS by ZVI was found to be attributed to the adsorption capability of iron oxides/hydroxides on ZVI surface at nearly neutral pH instead of the degradation at acidic condition...
January 31, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28133193/-a-case-of-adenocarcinoma-of-the-vater-papilla-treated-with-pancreatoduodenectomy-after-hepaticojejunostomy-for-prior-adenocarcinoma-of-the-gallbladder
#11
Yu Takeda, Yoshito Tomimaru, Kozo Noguchi, Hirotsugu Nagase, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Tomono Kawase, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Shiro Adachi, Keizo Dono
A 77-year-old man was diagnosed with acute cholecystitis and underwent laparoscopic cholecystectomy. Since adenocarcinoma in the gallbladder was detected by histopathological examination, he received additional resection for the carcinoma: partial hepatectomy(S4a, S5), extrahepatic bile duct resection, and hepaticojejunostomy. Five years after the surgery, he was diagnosed with adenocarcinoma of the Vater papilla. Pancreatoduodenectomy was performed. During the surgery, the prior hepaticojejunostomy and jejunojejunostomy were preserved, and the gastrointestinal tract was cut at the stomach and jejunum 5 cm from the Treitz ligament...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133168/-afferent-loop-syndrome-after-hepatobiliary-and-pancreatic-surgery-successfully-treated-with-percutaneous-drainage
#12
Terukazu Yoshihara, Yoshito Tomimaru, Kaishu Tanaka, Kozo Noguchi, Shiro Hayashi, Hirotsugu Nagase, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Tomono Kawase, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Keizo Dono
We report 2 cases where afferent loop syndrome after hepatobiliary and pancreatic surgery was successfully treated with percutaneous drainage. Case 1: A 74-year-old man who had undergone pancreaticoduodenectomy for pancreatic cancer presented with cholangitis, obstructive jaundice, and dilatation of the elevated jejunum. These conditions were attributed to obstruction of the elevated jejunum on the anal side due to peritoneal dissemination. Subsequently, percutaneous transhepatic biliary drainage was performed, and the dilated jejunum was drained through the approach route...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133130/-a-resected-case-of-intraductal-pupillary-mucinous-neoplasm-of-the-pancreas-characterized-by-recurrence-in-the-remnant-pancreas-and-multiple-malignant-neoplasms-in-other-organs
#13
Ryo Yoshioka, Yoshito Tomimaru, Kozo Noguchi, Hirotsugu Nagase, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Tomono Kawase, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Shiro Adachi, Keizo Dono
A 74-year-old man underwent pancreaticoduodenectomy for intraductal pupillary mucinous neoplasm(IPMN)of the pancreatic head. Histopathological examination of the specimen revealed non-invasive intraductal papillary mucinous carcinoma( IPMC). Two years after surgery, recurrent IPMN developed in the remnant pancreas, and a liver tumor was identified in S8 of the liver. The patient underwent total pancreatectomy of the remnant pancreas and partial resection of S8. These tumors were histopathologically diagnosed as invasive IPMC and hepatocellular carcinoma, respectively...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133072/-clinicopathological-study-of-incidental-gallbladder-cancer-diagnosed-after-laparoscopic-cholecystectomy
#14
Yoshito Tomimaru, Kozo Noguchi, Hirotsugu Nagase, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Tomono Kawase, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Keizo Dono
The aim of this study was to clarify the clinicopathological characteristics of incidental gallbladder cancer(iGBC)diagnosed after laparoscopic cholecystectomy. A total of 33 patients diagnosed with iGBC were enrolled in this study, and their clinicopathological characteristics were investigated. Preoperative diagnoses were as follows: cholelithiasis in 16 patients, polypoid lesions in 8, cholecystitis in 7, and adenomyomatosis in 2. Depth of mural invasion of iGBC was M in 14 cases, MP in 3, SS in 12, and deeper than SS in 4...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28132088/long-term-outcome-after-laparoscopic-gastrectomy-a-multicenter-retrospective-study
#15
Hiroshi Kawase, Yuma Ebihara, Toshiaki Shichinohe, Fumitaka Nakamura, Katsuhiko Murakawa, Takayuki Morita, Shunichi Okushiba, Satoshi Hirano
BACKGROUND: Despite its spread and advances, laparoscopic gastrectomy (LG) for advanced gastric cancer (AGC) remains controversial. The aim of this study was to evaluate the oncologic outcomes and to identify the potential risk factors for recurrence and survival after LG in AGC patients. PATIENTS AND METHODS: The medical records of patients who underwent radical LG for histopathologically diagnosed stage IB or more advanced gastric cancer from 2004 to 2012 were collected...
February 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28128691/nadh-fluorescence-imaging-and-the-histological-impact-of-cortical-spreading-depolarization-during-the-acute-phase-of-subarachnoid-hemorrhage-in-rats
#16
Tomohisa Shimizu, Tomohito Hishikawa, Shingo Nishihiro, Yukei Shinji, Yuji Takasugi, Jun Haruma, Masafumi Hiramatsu, Hirokazu Kawase, Sachiko Sato, Ryoichi Mizoue, Yoshimasa Takeda, Kenji Sugiu, Hiroshi Morimatsu, Isao Date
OBJECTIVE Although cortical spreading depolarization (CSD) has been observed during the early phase of subarachnoid hemorrhage (SAH) in clinical settings, the pathogenicity of CSD is unclear. The aim of this study is to elucidate the effects of loss of membrane potential on neuronal damage during the acute phase of SAH. METHODS Twenty-four rats were subjected to SAH by the perforation method. The propagation of depolarization in the brain cortex was examined by using electrodes to monitor 2 direct-current (DC) potentials and obtaining NADH (reduced nicotinamide adenine dinucleotide) fluorescence images while exposing the parietal-temporal cortex to ultraviolet light...
January 27, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28115744/a-genome-wide-association-study-identifies-two-novel-susceptibility-loci-and-trans-population-polygenicity-associated-with-bipolar-disorder
#17
M Ikeda, A Takahashi, Y Kamatani, Y Okahisa, H Kunugi, N Mori, T Sasaki, T Ohmori, Y Okamoto, H Kawasaki, S Shimodera, T Kato, H Yoneda, R Yoshimura, M Iyo, K Matsuda, M Akiyama, K Ashikawa, K Kashiwase, K Tokunaga, K Kondo, T Saito, A Shimasaki, K Kawase, T Kitajima, K Matsuo, M Itokawa, T Someya, T Inada, R Hashimoto, T Inoue, K Akiyama, H Tanii, H Arai, S Kanba, N Ozaki, I Kusumi, T Yoshikawa, M Kubo, N Iwata
Genome-wide association studies (GWASs) have identified several susceptibility loci for bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by polygenicity, with numerous variants contributing to BD. In the present GWAS (Phase I/II), which included 2964 BD and 61 887 control subjects from the Japanese population, we detected a novel susceptibility locus at 11q12.2 (rs28456, P=6.4 × 10(-9)), a region known to contain regulatory genes for plasma lipid levels (FADS1/2/3). A subsequent meta-analysis of Phase I/II and the Psychiatric GWAS Consortium for BD (PGC-BD) identified another novel BD gene, NFIX (Pbest=5...
January 24, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28110896/efficacy-and-safety-of-mepolizumab-in-japanese-patients-with-severe-eosinophilic-asthma
#18
Terufumi Shimoda, Hiroshi Odajima, Arisa Okamasa, Minako Kawase, Masaki Komatsubara, Bhabita Mayer, Steven Yancey, Hector Ortega
BACKGROUND: The MENSA trial assessed the efficacy and safety of mepolizumab in patients with severe eosinophilic asthma. This report describes the efficacy and safety of mepolizumab in Japanese patients from MENSA. METHODS: A post hoc analysis of the Japanese subgroup from the randomized, double-blind, placebo-controlled, double-dummy, Phase III MENSA trial (NCT01691521). Patients ≥12 years with severe eosinophilic asthma received mepolizumab 75 mg intravenously (IV), 100 mg subcutaneously (SC), or placebo, every 4 weeks for 32 weeks...
January 16, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/28102591/hyperinsulinemic-hypoglycemia-in-beckwith-wiedemann-sotos-and-kabuki-syndromes-a-nationwide-survey-in-japan
#19
Naoko Toda, Kenji Ihara, Kanako Kojima-Ishii, Masayuki Ochiai, Kazuhiro Ohkubo, Yutaka Kawamoto, Yoshinori Kohno, Sakae Kumasaka, Akihiko Kawase, Yasuhisa Ueno, Takeshi Futatani, Tokuo Miyazawa, Yuko Nagaoki, Setsuko Nakata, Maiko Misaki, Hiroko Arai, Masahiko Kawai, Maki Sato, Yukari Yada, Nobuhiro Takahashi, Atsushi Komatsu, Kanemasa Maki, Shinichi Watabe, Yutaka Sumida, Makoto Kuwashima, Hiroshi Mizumoto, Kazuo Sato, Toshiro Hara
Beckwith-Wiedemann syndrome (BWS) is a congenital overgrowth syndrome that is occasionally associated with hyperinsulinemic hypoglycemia (HH) in the neonatal period. Sotos syndrome (SS) and Kabuki syndrome (KS) are other malformation syndromes that may be complicated with HH, however, the detailed clinical characteristics of HH accompanied with these syndromes remain unclear. We herein conducted a nationwide questionnaire survey in Japan. We sent a primary questionnaire concerning the clinical experience for these syndromes to 347 perinatal care institutions...
February 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28087627/the-chemical-compound-bubblin-induces-stomatal-mispatterning-in-arabidopsis-by-disrupting-the-intrinsic-polarity-of-stomatal-lineage-cells
#20
Yumiko Sakai, Shigeo S Sugano, Takashi Kawase, Makoto Shirakawa, Yu Imai, Yusuke Kawamoto, Hiroshi Sugiyama, Tsuyoshi Nakagawa, Ikuko Hara-Nishimura, Tomoo Shimada
Stem cell polarization is a crucial step in asymmetric cell division, which is a universal system for generating cellular diversity in multicellular organisms. Several conventional genetics studies have attempted to elucidate the mechanisms underlying cell polarization in plants, but it remains largely unknown. In plants, stomata, which are valves for gas exchange, are generated through several rounds of asymmetric divisions. In this study, we identified and characterized a chemical compound that affects stomatal stem cell polarity...
February 1, 2017: Development
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