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https://www.readbyqxmd.com/read/27914472/the-response-to-receiving-phenotypic-and-genetic-coronary-heart-disease-risk-scores-and-lifestyle-advice-a-qualitative-study
#1
Guy Shefer, Barbora Silarova, Juliet Usher-Smith, Simon Griffin
BACKGROUND: Individuals routinely receive information about their risk of coronary heart disease (CHD) based on traditional risk factors as part of their primary care. We are also able to calculate individual's risk of CHD based on their genetic information and at present genetic testing for common diseases is available to the public. Due to the limitations in previous studies further understanding is needed about the impact of the risk information on individual's well-being and health-behaviour...
December 3, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27913059/cha2ds2-vasc-scores-and-major-bleeding-in-patients-with-nonvalvular-atrial-fibrillation-who-are-receiving-rivaroxaban
#2
W Frank Peacock, Sally Tamayo, Manesh Patel, Nicholas Sicignano, Kathleen P Hopf, Zhong Yuan
STUDY OBJECTIVE: Assessing stroke risk associated with nonvalvular atrial fibrillation depends on the evaluation of patient characteristics and clinical features. Clinicians must determine that the net clinical benefit from anticoagulation therapy outweighs its risk, namely, bleeding. Risk assessment for stroke is commonly performed by calculating a CHA2DS2-VASc (congestive heart failure/left ventricular dysfunction, hypertension, ≥75 years, diabetes mellitus, previous stroke or transient ischemic attack or thromboembolism, vascular disease, aged 65 to 74 years, sex female) score...
November 29, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27904512/evaluation-of-inhomogeneities-of-repolarization-in-patients-with-psoriasis-vulgaris
#3
Korhan Soylu, Sinan İnci, Gökhan Aksan, Gökay Nar, Esra Pancar Yüksel, Hande Serra Ocal, Mustafa Çapraz, Serkan Yüksel, Mahmut Şahin
INTRODUCTION: The arrhythmia potential has not been investigated adequately in psoriatic patients. In this study, we assessed the ventricular repolarization dispersion, using the Tp-e interval and the Tp-e/QT ratio, and investigated the association with inflammation. MATERIAL AND METHODS: Seventy-one psoriasis vulgaris patients and 70 age- and gender-matched healthy individuals were enrolled in the study. The severity of the disease was calculated using Psoriasis Area and Severity Index scoring...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27904510/correlation-between-plasma-angiopoietin-1-angiopoietin-2-and-matrix-metalloproteinase-2-in-coronary-heart-disease
#4
Haoyu Wu, Xiling Shou, Lei Liang, Congxia Wang, Xiaowei Yao, Gong Cheng
INTRODUCTION: Angiopoietin-2 (Ang-2) plays a critical role in inducing tumor cell infiltration, and this invasive phenotype is caused by up-regulation of matrix metalloproteinase (MMP)-2. The relationship between Ang-2 and MMP-2 in atherosclerosis has not been reported yet. The aim is to measure the plasma concentrations of Ang-1, Ang-2 and MMP-2 and assess the correlation between the concentrations of these factors in coronary heart disease (CHD) patients. MATERIAL AND METHODS: The testing was done in a cross-sectional study...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27903956/global-burden-of-all-cause-and-cause-specific-mortality-due-to-smokeless-tobacco-use-systematic-review-and-meta-analysis
#5
Dhirendra N Sinha, Rizwan A Suliankatchi, Prakash C Gupta, Thaksaphon Thamarangsi, Naveen Agarwal, Mark Parascandola, Ravi Mehrotra
OBJECTIVES: To systematically review and meta-analyse the studies investigating the association between smokeless tobacco (SLT) use and all-cause mortality and cause-specific mortality outcomes among adult users of SLT and estimate the number of attributable deaths worldwide. METHODS: Random-effects meta-analysis was used to estimate the pooled risk of death due to SLT use. Population attributable fractions were derived and used to calculate the number of attributable deaths...
November 30, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27902568/health-utilities-in-people-with-chronic-pain-using-a-population-level-survey-and-linked-healthcare-administrative-data
#6
Mary-Ellen Hogan BScPhm, Anna Taddio BScPhm, Joel Katz, Vibhuti Shah, Murray Krahn
Health utilities are a preference-based measure of health-related quality of life that facilitates comparison of disease burden across conditions. We estimated utilities using a population-based, matched sample of adolescents and adults with and without chronic pain, controlling for comorbidity.Ontarians aged ≥12 years with and without chronic pain were identified from the Canadian Community Health Survey (CCHS) 2000-01 and 2009-10 and linked to their provincial healthcare administrative data. Individuals with chronic pain were matched to those without using age, sex, survey year, and a propensity score for having chronic pain estimated from a rurality index, income quintile and comorbidity...
November 24, 2016: Pain
https://www.readbyqxmd.com/read/27901176/different-methods-of-calculating-ankle-brachial-index-in-mid-elderly-men-and-women-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#7
M Miname, I M Bensenor, P A Lotufo
The ankle-brachial index (ABI) is a marker of subclinical atherosclerosis related to health-adverse outcomes. ABI is inexpensive compared to other indexes, such as coronary calcium score and determination of carotid artery intima-media thickness (IMT). Our objective was to identify how the ABI can be applied to primary care. Three different methods of calculating the ABI were compared among 13,921 men and women aged 35 to 74 years who were free of cardiovascular diseases and enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)...
2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/27900942/association-between-chronic-kidney-disease-and-cancer-mortality-a-report-from-the-allhat
#8
Dhruti P Chen, Barry R Davis, Lara M Simpson, William C Cushman, Jeffrey A Cutler, Mirela Dobre, Charles E Ford, Gail T Louis, Paul Muntner, Suzanne Oparil, Linda B Piller, Sara L Pressel, Mark J Sarnak, Paul K Whelton, Jackson T Wright, Mahboob Rahman
BACKGROUND/OBJECTIVES: Chronic kidney disease (CKD) and cancer are both common in older patients; whether CKD increases risk for cancer is unclear. This study evaluated CKD as a risk factor for cancer mortality in a large cohort of hypertensive patients. STUDY DESIGN: We did post-hoc analyses of in-trial and post-trial data from participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). SETTING AND PARTICIPANTS: Participants were ≥ 55 years old with hypertension and one other additional risk factor for coronary heart disease...
November 30, 2016: Clinical Nephrology
https://www.readbyqxmd.com/read/27900498/central-hemodynamics-and-arterial-stiffness-in-idiopathic-and-multiple-system-atrophy
#9
Klaas Franzen, Sabine Fliegen, Jelena Koester, Rafael Campos Martin, Günther Deuschl, Michael Reppel, Kai Mortensen, Susanne A Schneider
Blood pressure is commonly abnormal in parkinsonian disorders, but central hemodynamics and arterial stiffness, well-established predictors of total cardiovascular risk, have rarely been studied in these disorders. 32 patients [27 with idiopathic Parkinson's disease (iPD); 5 with multiple system atrophy (MSA)] and 15 controls matched for cardiac risk factors underwent 24 h-ambulatory blood pressure recordings using an I.E.M. device (Mobil-O-Graph™), measuring peripheral pressure and calculating central pressures and arterial stiffness...
November 29, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27899087/paradoxical-physiological-responses-to-propranolol-in-a-rett-syndrome-patient-a-case-report
#10
P J Santosh, L Bell, K Lievesley, J Singh, F Fiori
BACKGROUND: Rett Syndrome (RTT), caused by a loss-of-function in the epigenetic modulator: X-linked methyl-CpG binding protein 2 (MeCP2), is a pervasive neurological disorder characterized by compromised brain functions, anxiety, severe mental retardation, language and learning disabilities, repetitive stereotyped hand movements and developmental regression. An imbalance in the sympathetic and the parasympathetic nervous system (dysautonomia) and the resulting autonomic storms is a frequent occurrence in patients with RTT...
November 29, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27898687/effects-of-chronologic-age-and-young-child-exposure-on-respiratory-syncytial-virus-disease-among-us-preterm-infants-born-at-32-to-35-weeks-gestation
#11
Eric A F Simões, Evan J Anderson, Xionghua Wu, Christopher S Ambrose
OBJECTIVE: To estimate the incidence of respiratory syncytial virus (RSV) disease as a function of chronologic age and exposure to young children in US preterm infants. METHODS: In the RSV Respiratory Events among Preterm Infants Outcomes and Risk Tracking (REPORT) study, preterm infants born at 32-35 weeks gestational age (wGA) were enrolled from 188 US clinics and followed September-May of 2009-2010 or 2010-2011. Infants with medically-attended acute respiratory illness had nasal/pharyngeal swabs collected for viral testing...
2016: PloS One
https://www.readbyqxmd.com/read/27898293/metabolic-syndrome-among-adults-in-china-the-2010-china-noncommunicable-disease-surveillance
#12
Jieli Lu, Limin Wang, Mian Li, Yu Xu, Yong Jiang, Weiqing Wang, Jianhong Li, Shengquan Mi, Mei Zhang, Yichong Li, Tiange Wang, Min Xu, Zhiyun Zhao, Meng Dai, Shenghan Lai, Wenhua Zhao, Linhong Wang, Yufang Bi, Guang Ning
CONTEXT: In China, data on the prevalence of metabolic syndrome have been rare recently. OBJECTIVE: The objective of the study was to evaluate the prevalence of metabolic syndrome and its components in 2010. DESIGN, SETTING AND PARTICIPANTS: The study covered all 31 provinces of mainland China and consisted of a nationally representative population sample of 98,658 Chinese adults aged ≥ 18 years. Of these, 97,098 participants were eligible for the data analysis reported here...
November 29, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27894953/biological-variability-of-lipoprotein-associated-phospholipase-a2activity-in-healthy-individuals
#13
Leslie J Donato, Jeffrey W Meeusen, Sarah M Jenkins, Stacy J Hartman, Amy K Saenger, Nikola A Baumann, Darci R Block, Allan S Jaffe
OBJECTIVES: Measuring lipoprotein-associated phospholipase A2 (Lp-PLA2) activity can aid in identifying individuals at higher risk of coronary heart disease. However, the biological variation of Lp-PLA2 activity and corresponding reference change value (RCV) is unknown which limits interpretation of results. In this study we aim to define the intra- and inter-individual variability of Lp-PLA2 activity in a healthy reference population. METHODS: A total of 24 healthy individuals (22-47years of age) were prospectively collected at several time points: daily for five days (after overnight fast), daily for three days (while non-fasting), weekly for four weeks (after overnight fast), and monthly for 6months (after overnight fast)...
November 25, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27893863/high-vitamin-d-consumption-is-inversely-associated-with-cardiovascular-disease-risk-in-an-urban-mexican-population
#14
Paloma Muñoz-Aguirre, Edgar Denova-Gutiérrez, Mario Flores, Eduardo Salazar-Martínez, Jorge Salmerón
BACKGROUND: Vitamin D deficiency is a major global public health problem. Recent epidemiological studies have assessed the relationship between vitamin D and multiple outcomes, including cardiovascular disease. However, this evidence is limited and inconclusive. Our purpose in this study was to evaluate the association between dietary vitamin D intake and cardiovascular disease risk in adult Mexican population. METHODS: We conducted a cross-sectional analysis with the baseline data from 6294 men and women aged 20-80 years participating in the Health Workers Cohort Study...
2016: PloS One
https://www.readbyqxmd.com/read/27884118/burden-of-clostridium-difficile-associated-disease-among-patients-residing-in-nursing-homes-a-population-based-cohort-study
#15
Holly Yu, Onur Baser, Li Wang
BACKGROUND: Clostridium difficile (C. difficile) infection (CDI) is the leading cause of nosocomial diarrhea in the United States. This study aimed to examine the incidence of CDI and evaluate mortality and economic burden of CDI in an elderly population who reside in nursing homes (NHs). METHODS: This was a population-based retrospective cohort study focusing on US NHs by linking Medicare 5% sample, Medicaid, Minimum Data Set (MDS) (2008-10). NH residents aged ≥65 years with continuous enrollment in Medicare and/or Medicaid Fee-for-Service plan for ≥12 months and ≥2 quarterly MDS assessments were eligible for the study...
November 25, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/27883976/prognostic-value-of-liver-dysfunction-assessed-by-meld-xi-scoring-system-in-patients-undergoing-transcatheter-aortic-valve-implantation
#16
Takahide Arai, Fumiaki Yashima, Ryo Yanagisawa, Makoto Tanaka, Hideyuki Shimizu, Keiichi Fukuda, Yusuke Watanabe, Toru Naganuma, Motoharu Araki, Norio Tada, Futoshi Yamanaka, Shinichi Shirai, Masanori Yamamoto, Kentaro Hayashida
BACKGROUND: There are limited data regarding the influence of liver dysfunction on outcomes of transcatheter aortic valve implantation (TAVI). Model for End-stage Liver Disease eXcluding International normalized ratio (MELD-XI) score, which was originally developed for patients with cirrhosis awaiting liver transplantation, has been reported as a predictor of heart disease. The aim of this study was to investigate the prognostic value of MELD-XI score for patients undergoing TAVI. METHODS: Data from the prospectively maintained Optimized transCathEter vAlvular iNtervention (OCEAN-TAVI) multicenter registry were collected in 749 patients who underwent TAVI between October 2013 and August 2015...
November 10, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27881424/temporal-reduction-in-chronotropic-index-predicts-risk-of-cardiovascular-death-among-healthy-middle-aged-men-a-28-year-follow-up-study
#17
Kristian Engeseth, Christian Hodnesdal, Irene Grundvold, Knut Liestøl, Knut Gjesdal, Sverre E Kjeldsen, Jan E Erikssen, Johan Bodegard, Per Torger Skretteberg
BACKGROUND: Chronotropic index is a standardized measure of heart rate (HR) increment during exercise that reflects the combined effects of age, resting HR, and physical fitness. Low chronotropic index has been reported to predict disease and death. We tested whether temporal change in chronotropic index over 7 years influenced risk of cardiovascular death through up to 28 years. METHODS AND RESULTS: Chronotropic index was calculated ([achieved maximal HR-resting HR]/[age-predicted maximal HR-resting HR]) after a symptom-limited bicycle ECG exercise test in 1420 healthy men at 2 examinations 7 years apart, in 1972 and 1979...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27881363/association-between-prediabetes-and-risk-of-cardiovascular-disease-and-all-cause-mortality-systematic-review-and-meta-analysis
#18
Yuli Huang, Xiaoyan Cai, Weiyi Mai, Meijun Li, Yunzhao Hu
OBJECTIVES:  To evaluate associations between different definitions of prediabetes and the risk of cardiovascular disease and all cause mortality. DESIGN:  Meta-analysis of prospective cohort studies. DATA SOURCES:  Electronic databases (PubMed, Embase, and Google Scholar). SELECTION CRITERIA:  Prospective cohort studies from general populations were included for meta-analysis if they reported adjusted relative risks with 95% confidence intervals for associations between the risk of composite cardiovascular disease, coronary heart disease, stroke, all cause mortality, and prediabetes...
November 23, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27879970/mortality-hospital-days-and-expenditures-attributable-to-ambient-air-pollution-from-particulate-matter-in-israel
#19
Gary M Ginsberg, Ehud Kaliner, Itamar Grotto
BACKGROUND: Worldwide, ambient air pollution accounts for around 3.7 million deaths annually. Measuring the burden of disease is important not just for advocacy but also is a first step towards carrying out a full cost-utility analysis in order to prioritise technological interventions that are available to reduce air pollution (and subsequent morbidity and mortality) from industrial, power generating and vehicular sources. METHODS: We calculated the average national exposure to particulate matter particles less than 2...
2016: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/27878625/reference-ranges-of-fetal-cardiac-biometric-parameters-using-three-dimensional-ultrasound-with-spatiotemporal-image-correlation-m%C3%A2-mode-and-their-applicability-in-congenital-heart-diseases
#20
Giselle Darahem Tedesco, Marilim de Souza Bezerra, Fernanda Silveira Bello Barros, Wellington P Martins, Luciano Marcondes Machado Nardozza, Milene Carvalho Carrilho, Antonio Fernandes Moron, Francisco Herlânio Costa Carvalho, Liliam Cristine Rolo, Edward Araujo Júnior
To determine reference values for fetal heart biometric parameters using the spatiotemporal image correlation (STIC) M mode and their applicability in congenital heart diseases (CHDs). A cross-sectional prospective study was conducted with 300 singleton pregnancies between 20 and 33 + 6 weeks of gestation. Right ventricular wall thickness (RVWT), interventricular septum thickness (IVST), and left ventricular wall thickness (LVWT) were measured off-line using the STIC-M mode with the cursor perpendicular to the interventricular septum...
November 23, 2016: Pediatric Cardiology
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