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https://www.readbyqxmd.com/read/29926995/prevalence-of-combined-and-noncombined-dyslipidemia-in-an-iranian-population
#1
Susan Darroudi, Maryam Saberi-Karimian, Maryam Tayefi, Soheil Arekhi, Ali Motamedzadeh Torghabeh, Seyed Mohammad Reza Seyedzadeh Sani, Mohsen Moohebati, Alireza Heidari-Bakavoli, Mahmoud Ebrahimi, Mahmoud Reza Azarpajouh, Mohammad Safarian, Gordon A Ferns, Habibollah Esmaeili, Mohammad Reza Parizadeh, Naghme Mokhber, Adeleh Mahdizadeh, Ali Asghar Mahmoudi, Amir Hossein Sahebkar, Majid Ghayour-Mobarhan
BACKGROUND: Combination of dyslipidemic phenotypes, including elevated plasma levels of low-density lipoprotein cholesterol (LDL-C), elevated plasma triglycerides (TG), and decreased low-density lipoprotein cholesterol (HDL-C) concentrations, is important because of the association of individual phenotypes with increased risk of cardiovascular disease (CVD). We investigated the prevalence of combined dyslipidemias and their effects on CVD risk in an Iranian large population. METHOD: A total of 9847 individuals were recruited as part of the Mashhad Stroke and Heart Atherosclerotic Disorders (MASHAD) cohort study...
June 21, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29921571/marital-status-and-risk-of-cardiovascular-diseases-a-systematic-review-and-meta-analysis
#2
Chun Wai Wong, Chun Shing Kwok, Aditya Narain, Martha Gulati, Anastasia S Mihalidou, Pensee Wu, Mirvat Alasnag, Phyo Kyaw Myint, Mamas A Mamas
BACKGROUND: The influence of marital status on the incidence of cardiovascular disease (CVD) and prognosis after CVD is inconclusive. We systematically reviewed the literature to determine how marital status influences CVD and prognosis after CVD. METHODS: A search of MEDLINE and Embase in January 2018 without language restriction was performed to identify studies that evaluated the association between marital status and risk of CVD. Search terms related to both marital status and CVD were used and included studies had to be prospective in design...
June 19, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29920438/life-s-simple-7-and-the-risk-of-atrial-fibrillation-the-multi-ethnic-study-of-atherosclerosis
#3
Oluseye Ogunmoroti, Erin D Michos, Konstantinos N Aronis, Joseph A Salami, Ron Blankstein, Salim S Virani, Erica S Spatz, Norrina B Allen, Jamal S Rana, Roger S Blumenthal, Emir Veledar, Moyses Szklo, Michael J Blaha, Khurram Nasir
BACKGROUND AND AIMS: We examined the association between the American Heart Association's Life's Simple 7 (LS7) metrics and the risk of atrial fibrillation (AF) in the Multi-Ethnic Study of Atherosclerosis (MESA), a prospective cohort study of adults free of cardiovascular disease (CVD) at baseline. METHODS: We analyzed data from 6506 participants. The LS7 metrics (smoking, physical activity, body mass index, diet, blood pressure, total cholesterol and blood glucose) were each categorized into ideal (assigned 2 points), intermediate (1 point) or poor (0 points)...
June 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29920124/long-term-incidence-and-risk-factors-of-cardiovascular-events-in-asian-populations-systematic-review-and-meta-analysis-of-population-based-cohort-studies
#4
Sylvi Irawati, Riswandy Wasir, Amand Floriaan Schmidt, Atiqul Islam, Talitha Feenstra, Erik Buskens, Bob Wilffert, Eelko Hak
BACKGROUND: Scientific studies on cardiovascular disease (CVD) burden and risk factors is predominantly based on short-term risk in Westerner populations, and such information may not be applicable to Asian populations, especially over the longer-term. This review aims to estimate the long-term (> 10 years) CVD burden, including coronary heart disease (CHD) and stroke, as well as associated risk factors in Asian populations. METHODS: PubMed®, Embase® , Web of ScienceTM were systematically searched, and hits screened on: Asian adults, free of CVD at baseline; cohort study design (follow-up > 10 years)...
June 19, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29913019/association-of-obesity-or-weight-change-with-coronary-heart-disease-among-young-adults-in-south-korea
#5
Seulggie Choi, Kyuwoong Kim, Sung Min Kim, Gyeongsil Lee, Su-Min Jeong, Seong Yong Park, Yeon-Yong Kim, Joung Sik Son, Jae-Moon Yun, Sang Min Park
Importance: Previous studies have shown a U- or J-shaped association of body mass index (BMI) or change in BMI with coronary heart disease (CHD) among middle-aged and elderly adults. However, whether a similar association exists among young adults is unclear. Objective: To determine whether an association exists between BMI or BMI change with CHD among young adults. Design, Setting, and Participants: This population-based longitudinal study used data obtained by the Korean National Health Insurance Service from 2002 to 2015...
June 18, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29908725/validation-and-reference-values-for-three-dimensional-echocardiographic-right-ventricular-volumetry-in-children-a-multicenter-study
#6
Kai Thorsten Laser, Ayşe Karabiyik, Hermann Körperich, Jan-Pit Horst, Peter Barth, Deniz Kececioglu, Wolfgang Burchert, Robert DallaPozza, Ulrike Herberg
BACKGROUND: Functional assessment of the right ventricle using real-time three-dimensional echocardiography (RT3DE) has fundamental relevance in young patients with congenital heart disease. Reference values for the pediatric population are scarce. This multicenter study was designed to (1) validate new evaluation software for RT3DE and (2) establish pediatric reference values. METHODS: For validation, right ventricular (RV) end-diastolic volume (EDV) and end-systolic volume (ESV) were determined from real-time three-dimensional echocardiographic data sets of 38 subjects (n = 17 healthy individuals and n = 21 patients with congenital heart disease) using new dedicated evaluation software (RV-Function 2...
June 13, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29899017/statin-eligibility-coronary-artery-calcium-and-subsequent-cardiovascular-events-according-to-the-2016-united-states-preventive-services-task-force-uspstf-statin-guidelines-mesa-multi-ethnic-study-of-atherosclerosis
#7
Michael D Miedema, Zeina A Dardari, Sina Kianoush, Salim S Virani, Joseph Yeboah, Thomas Knickelbine, Veit Sandfort, Carlos J Rodriguez, Khurram Nasir, Michael J Blaha
BACKGROUND: The potential impact of the 2016 United States Preventive Services Task Force (USPSTF) guidelines on statins for primary prevention of atherosclerotic cardiovascular disease (ASCVD) warrants further analysis. METHODS AND RESULTS: We studied participants from MESA (Multi-Ethnic Study of Atherosclerosis) aged 40 to 75 years and not on statins. We compared statin eligibility at baseline (2000-2002) and over follow-up between USPSTF and the 2013 American College of Cardiology/American Heart Association (ACC/AHA) guidelines...
June 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29896874/is-self-rated-health-associated-with-ideal-cardiovascular-health-the-multi-ethnic-study-of-atherosclerosis
#8
Olatokunbo Osibogun, Oluseye Ogunmoroti, Erica S Spatz, Gregory L Burke, Erin D Michos
BACKGROUND: Self-rated health (SRH) is an indicator of health status. It is a determinant of health-promoting behaviors and predictor of morbidity and mortality. Yet, little is known about the association between SRH and ideal cardiovascular health (CVH) as measured by the American Heart Association Life's Simple Seven (LS7) metrics, or whether the relation of SRH and CVH differ by race/ethnicity. HYPOTHESIS: Favorable SRH is associated with better CVH. METHODS: We conducted a cross-sectional analysis of 6457 men and women of 4 race/ethnicities who participated in the Multi-Ethnic Study of Atherosclerosis...
June 12, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29896071/molecular-assessment-of-some-cardiovascular-genetic-risk-factors-among-iraqi-patients-with-ischemic-heart-diseases
#9
Wisam Jasim Mohammed, Bassam Musa Sadik Al-Musawi, Christian Oberkanins, Helene Pühringer
Objective: The underlying molecular basis of ischemic heart diseases (IHDs) has not yet been studied among Iraqi people. This study determined the frequency and types of some cardiovascular genetic risk factors among Iraqi patients with IHDs. Methods: This is a cross-sectional study recruiting 56 patients with acute IHD during a 2-month period excluding patients >50 years and patients with documented hyperlipidemia. Their ages ranged between 18 and 50 years; males were 54 and females were only 2...
May 2018: International Journal of Health Sciences
https://www.readbyqxmd.com/read/29891175/impact-of-smoking-cessation-on-estimated-cardiovascular-risk-in-spanish-type-2-diabetes-mellitus-patients-the-diabetes-study
#10
M Luque-Ramírez, V Sanz de Burgoa
AIMS: To assess the cardiovascular risk according to the UKPDS risk engine; Framingham function and score comparing clinical characteristics of diabetes mellitus type 2 (DM2) patients according to their habits status. PATIENTS AND METHODS: A descriptive analysis was performed. A total of 890 Spanish patients with DM2 (444 smokers and 446 former-smokers) were included in a cross-sectional, observational, epidemiological multicenter nationwide study. Coronary heart disease risk at 10 years was calculated using the UKPDS risk score in both patient subgroups...
June 8, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29890892/group-sequential-designs-with-robust-semiparametric-recurrent-event-models
#11
Tobias Mütze, Ekkehard Glimm, Heinz Schmidli, Tim Friede
Robust semiparametric models for recurrent events have received increasing attention in the analysis of clinical trials in a variety of diseases including chronic heart failure. In comparison to parametric recurrent event models, robust semiparametric models are more flexible in that neither the baseline event rate nor the process inducing between-patient heterogeneity needs to be specified in terms of a specific parametric statistical model. However, implementing group sequential designs in the robust semiparametric model is complicated by the fact that the sequence of Wald statistics does not follow asymptotically the canonical joint distribution...
January 1, 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29890446/modified-creatinine-index-and-risk-for-cardiovascular-events-and-all-cause-mortality-in-patients-undergoing-hemodialysis-the-q-cohort-study
#12
Hokuto Arase, Shunsuke Yamada, Ryusuke Yotsueda, Masatomo Taniguchi, Hisako Yoshida, Masanori Tokumoto, Toshiaki Nakano, Kazuhiko Tsuruya, Takanari Kitazono
BACKGROUND AND AIMS: The modified creatinine (Cr) index, calculated by age, sex, pre-dialysis serum Cr levels, and Kt/V for urea, reflects skeletal muscle mass in patients on hemodialysis. Whether the modified Cr index is associated with cardiovascular events and all-cause mortality remains unknown. METHODS: A total of 3027 patients registered in the Q-Cohort Study, a multicenter, prospective study of patients on hemodialysis in Japan, were analyzed. The main outcomes were cardiovascular events and all-cause mortality...
June 2, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29890324/white-matter-injury-in-term-neonates-with-congenital-heart-diseases-topology-comparison-with-preterm-newborns
#13
REVIEW
Ting Guo, Vann Chau, Shabnam Peyvandi, Beatrice Latal, Patrick S McQuillen, Walter Knirsch, Anne Synnes, Maria Feldmann, Nadja Naef, M Mallar Chakravarty, Alessandra De Petrillo, Emma G Duerden, A James Barkovich, Steven P Miller
BACKGROUND: Neonates with congenital heart disease (CHD) are at high risk of punctate white matter injury (WMI) and impaired brain development. We hypothesized that WMI in CHD neonates occurs in a characteristic distribution that shares topology with preterm WMI and that lower birth gestational age (GA) is associated with larger WMI volume. OBJECTIVE: (1) To quantitatively assess the volume and location of WMI in CHD neonates across three centres. (2) To compare the volume and spatial distribution of WMI between term CHD neonates and preterm neonates using lesion mapping...
June 8, 2018: NeuroImage
https://www.readbyqxmd.com/read/29889687/associations-of-source-apportioned-fine-particles-with-cause-specific-mortality-in-california
#14
Kimberly Berger, Brian J Malig, Sina Hasheminassab, Dharshani L Pearson, Constantinos Sioutas, Bart Ostro, Rupa Basu
BACKGROUND: Exposure to ambient fine particulate matter (PM2.5) has been linked with premature mortality, but sources of PM2.5 have been less studied. METHODS: We evaluated associations between source-specific PM2.5 exposures and cause-specific short-term mortality in eight California locations from 2002-2011. Speciated PM2.5 measurements were source-apportioned using Positive Matrix Factorization into eight sources and combined with death certificate data. We utilized time-stratified case-crossover analysis with conditional logistic regression by location, and meta-analysis to calculate pooled estimates...
June 6, 2018: Epidemiology
https://www.readbyqxmd.com/read/29888950/comparison-of-amlodipine-versus-other-calcium-channel-blockers-on-blood-pressure-variability-in-hypertensive-patients-in-china-a-retrospective-propensity-score-matched-analysis
#15
Lin Zhang, JinKui Yang, LanTing Li, DongDong Liu, XiaoPing Xie, Peng Dong, Yong Lin
AIM: Reducing the fluctuation of blood pressure has recently been recognized as a potential target for improving management of hypertension to prevent cardiovascular events, particularly for strokes. Some randomized controlled trials demonstrated that amlodipine can effectively reduce blood pressure as a well-established, long-acting calcium channel blocker (CCB). However, few data are available for amlodipine on blood pressure variability (BPV) in China in a real-world setting. This study aimed to assess the effect of amlodipine versus other CCB antihypertensive agents on BPV...
June 11, 2018: Journal of Comparative Effectiveness Research
https://www.readbyqxmd.com/read/29886624/-establishment-and-evaluation-of-a-new-method-for-determining-hemodynamics-of-pulmonary-hypertension-rats
#16
Q Y Zheng, M D Kuang, Y Li, X T Wu, J Y Huang, C T Zhang, H W Liu, W J Lu, J Wang, Y Q Chen
Objective: By evaluating the hemodynamic parameters such as cardiac output (CO), right ventricular pressure (RVP), pulmonary artery pressure (PAP) and total pulmonary resistance index (TPRI) in pulmonary hypertension rat model, we established a more comprehensive hemodynamic evaluation system, which objectively evaluated the severity of disease and exercise tolerance in rats with pulmonary hypertension. Methods: SD rats were randomly divided into a control group and a model group with 5 rats in each group. The model group was intraperitoneally injected with SU5416 (20 mg/kg) and placed in an oxygen chamber at a 10% oxygen concentration for 21 days and then placed in a normoxic environment for 14 days...
June 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29885923/bioelectrical-impedance-analysis-measures-and-clinical-outcomes-in-ckd
#17
Nisha Bansal, Leila R Zelnick, Jonathan Himmelfarb, Glenn M Chertow
RATIONALE & OBJECTIVE: Bioelectrical impedance analysis (BIA) provides a noninvasive assessment of body composition. BIA measures of cell integrity (phase angle) and hydration (vector length) have been associated with mortality among patients receiving dialysis. Whether these measures are associated with clinical outcomes in patients with chronic kidney disease (CKD) is unknown. STUDY DESIGN: Observational study. SETTINGS & PARTICIPANTS: We studied 3,751 participants with CKD in the prospective multicenter Chronic Renal Insufficiency Cohort (CRIC) who had baseline single-frequency BIA performed...
June 6, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29882346/efficacy-of-prophylactic-dexmedetomidine-in-preventing-postoperative-junctional-ectopic-tachycardia-in-pediatric-cardiac-surgery-patients-a-systematic-review-and-meta-analysis
#18
REVIEW
Laxmi V Ghimire, Fu-Sheng Chou
BACKGROUND: Junctional ectopic tachycardia is a serious tachyarrhythmic complication following pediatric cardiac surgery. It is difficult to manage and is associated with significant morbidity and mortality. Conventional nonpharmacological and pharmacological measures have shown limited effects. Dexmedetomidine is an α2 agonist which has recently been shown in multiple studies to be effective. AIMS: The aim of this systematic review with meta-analysis was to evaluate the efficacy of prophylactic dexmedetomidine administration in the prevention of junctional ectopic tachycardia in pediatric patients following cardiac surgeries...
June 7, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29881259/incidence-and-risk-of-cardiac-toxicities-in-patients-with-relapsed-and-refractory-multiple-myeloma-treated-with-carfilzomib
#19
Fang Zhao, Bo Yang, Juan Wang, Rui Zhang, Jing Liu, Fenglei Yin, Weixing Xu, Chunyuan He
Purpose: Carfilzomib has been approved for use in relapsed and refractory multiple myeloma (RRMM). Cardiac toxicities have been reported with the use of carfilzomib. We aimed to determine the overall incidence and risk of cardiac toxicities in RRMM patients treated with carfilzomib using a meta-analysis. Methods: We searched several databases for relevant articles. Prospective trials evaluating carfilzomib in RRMM patients with adequate data on cardiac toxicities were included for analysis...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29880501/sleep-apnea-and-cardiovascular-disease-an-enigmatic-risk-factor
#20
REVIEW
John S Floras
Synchronization of molecular, metabolic, and cardiovascular circadian oscillations is fundamental to human health. Sleep-disordered breathing, which disrupts such temporal congruence, elicits hemodynamic, autonomic, chemical, and inflammatory disturbances with acute and long-term consequences for heart, brain, and circulatory and metabolic function. Sleep apnea afflicts a substantial proportion of adult men and women but is more prevalent in those with established cardiovascular diseases and especially fluid-retaining states...
June 8, 2018: Circulation Research
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