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https://www.readbyqxmd.com/read/29453747/clinical-applications-of-patient-specific-models-the-case-for-a-simple-approach
#1
Jeffrey W Holmes, Joost Lumens
Over the past several decades, increasingly sophisticated models of the heart have provided important insights into cardiac physiology and are increasingly used to predict the impact of diseases and therapies on the heart. In an era of personalized medicine, many envision patient-specific computational models as a powerful tool for personalizing therapy. Yet the complexity of current models poses important challenges, including identifying model parameters and completing calculations quickly enough for routine clinical use...
February 16, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29448840/inverse-association-between-serum-albumin-and-future-risk-of-venous-thromboembolism-interrelationship-with-high-sensitivity-c-reactive-protein
#2
Setor K Kunutsor, Samuel Seidu, Devvrat T Katechia, Jari A Laukkanen
PURPOSE: We aimed to assess the prospective association of serum albumin with venous thromboembolism (VTE) risk and evaluate if the association is independent of or modified by inflammation, as measured by high sensitivity C-reactive protein (hsCRP). DESIGN: We analyzed data of 2,176 men aged 42-61 years free from VTE in the Kuopio Ischemic Heart Disease study, with serum albumin concentrations measured at baseline using Coulter's bromcresol purple colorimetric assays...
February 16, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29447429/arterial-stiffness-and-subendocardial-viability-ratio-in-patients-with-peripheral-arterial-disease
#3
Giovanni Scandale, Gabriel Dimitrov, Martino Recchia, Gianni Carzaniga, Marzio Minola, Edoardo Perilli, Maria Carotta, Mariella Catalano
Arterial stiffening is a hallmark of the aging process and atherosclerosis, including peripheral arterial disease (PAD). We investigated the associations between carotid-femoral pulse wave velocity (c-fPWV), augmentation index corrected for heart rate (Aix@HR75), ankle brachial index (ABI), and subendocardial viability ratio (SEVR), an indicator of cardiac perfusion. The c-fPWV, Aix@HR75, and SEVR was estimated using applanation tonometry. The ankle systolic pressure measurements for the calculation of the ABI were obtained using an 8-mHz Doppler probe...
February 15, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29444987/cardiovascular-risk-prediction-functions-underestimate-risk-in-hiv-infection
#4
Virginia A Triant, Jeremiah Perez, Susan Regan, Joseph M Massaro, James B Meigs, Steven K Grinspoon, Ralph B D'Agostino
Background -Cardiovascular disease (CVD) risk is elevated in HIV-infected individuals, with contributions from both traditional and non-traditional risk factors. The accuracy of established CVD risk prediction functions in HIV is uncertain. We sought to assess the performance of three established CVD risk prediction functions in a longitudinal cohort of HIV-infected men. Methods -Framingham Heart Study (Framingham) functions for hard coronary heart disease (Framingham CHD) and atherosclerotic CVD (Framingham ASCVD) and the American College of Cardiology/American Heart Association (ACC/AHA ASCVD) function were applied to the Partners HIV cohort...
February 14, 2018: Circulation
https://www.readbyqxmd.com/read/29440011/different-weight-histories-and-risk-of-incident-coronary-heart-disease-and-stroke-tehran-lipid-and-glucose-study
#5
Maryam Kabootari, Samaneh Asgari, Mohammad Ali Mansournia, Davood Khalili, Majid Valizadeh, Fereidoun Azizi, Farzad Hadaegh
BACKGROUND: This study aimed to determine the association between different weight histories, including cumulative excess weight, cumulative excess waist circumference (WC), duration of general and central adiposity, current and maximum body mass index, and current and maximum WC, and incident coronary heart disease (CHD) and stroke. METHODS AND RESULTS: The study population consisted of 4398 adults aged ≥40 years without CHD or stroke at baseline. Associations between different weight histories and CHD and stroke were determined by multivariable time-varying Cox regression models after adjustment for age, sex, and time-varying confounders...
February 10, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29434010/national-prevalence-of-self-reported-coronary-heart-disease-and-chronic-stable-angina-pectoris-factor-analysis-of-the-underlying-cardiometabolic-risk-factors-in-the-fourth-round-of-the-surfncd-2011
#6
Mehrshad Abbasi, Mohamadreza Neishaboury, Jalil Koohpayehzadeh, Koorosh Etemad, Alipasha Meysamie, Fereshteh Asgari, Sina Noshad, Mohsen Afarideh, Alireza Ghajar, Morsaleh Ganji, Ali Rafei, Mostafa Mousavizadeh, Elias Khajeh, Behnam Heidari, Mohammad Saadat, Manouchehr Nakhjavani, Alireza Esteghamati
BACKGROUND: Coronary heart disease (CHD) is one of the most common causes of mortality worldwide. The national prevalence remains unclear in most of the developing countries. OBJECTIVE: This study sought to estimate national prevalence of self-reported CHD and chronic stable angina pectoris in the general adult population of Iran using data from the fourth round of the Surveillance of Risk Factors of Non-Communicable Diseases (SuRFNCD-2011) survey. METHODS: The analysis comprised data of 11,867 civilian, nonhospitalized and noninstitutionalized residents ages 6 to 70 years of age...
February 9, 2018: Global Heart
https://www.readbyqxmd.com/read/29431470/economic-evaluation-of-safflower-yellow-injection-for-the-treatment-of-patients-with-stable-angina-pectoris-in-china-a-cost-effectiveness-analysis
#7
Jianwei Xuan, Min Huang, Yongji Lu, Libo Tao
OBJECTIVE: The purpose of this study was to evaluate the cost-effectiveness of Safflower Yellow Injection (SYI) plus conventional treatment (SYI group) versus conventional treatment only (conventional group) for the treatment of stable angina pectoris (SAP) patients in China. METHODS: A decision-tree model was constructed and the treatment impact was estimated for up to 1 year. The data, including treatment effectiveness, episodes of angina pectoris (AP)-associated hospitalization and its in-hospital mortality, mortality rate of heart diseases, and cost of hospitalization, were obtained from literature...
February 12, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29431107/ideal-cardiovascular-health-and-the-prevalence-and-severity-of-aortic-stenosis-in-elderly-patients
#8
Morten Sengeløv, Susan Cheng, Tor Biering-Sørensen, Kunihiro Matsushita, Suma Konety, Scott D Solomon, Aaron R Folsom, Amil M Shah
BACKGROUND: The relationship between ideal cardiovascular health reflected in the cardiovascular health score (CVHS) and valvular heart disease is not known. The purpose of this study was to determine the association of CVHS attainment through midlife to late life with aortic stenosis prevalence and severity in late life. METHODS AND RESULTS: The following 6 ideal cardiovascular health metrics were assessed in ARIC (Atherosclerosis Risk in Communities) Study participants at 5 examination visits between 1987 and 2013 (visits 1-4 in 1987-1998 and visit 5 in 2011-2013): smoking, body mass index, total cholesterol, blood pressure, physical activity, and blood glucose...
February 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29430653/regression-equations-for-calculation-of-z-scores-for-echocardiographic-measurements-of-left-heart-structures-in-healthy-han-chinese-children
#9
Shan-Shan Wang, Wen-Jing Hong, Yu-Qi Zhang, Shu-Bao Chen, Guo-Ying Huang, Hong-Yan Zhang, Li-Jun Chen, Lan-Ping Wu, Rong Shen, Yi-Qing Liu, Jun-Xue Zhu
OBJECTIVE: Clinical decision making in children with heart disease relies on detailed measurements of cardiac structures using two-dimensional and M-mode echocardiography. However, no echocardiographic reference values are available for the Chinese children. We aimed to establish z-score regression equations for left heart structures in a population-based cohort of healthy Chinese Han children. METHOD: Echocardiography was performed in 545 children with a normal heart...
February 12, 2018: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29428537/neutrophil-to-lymphocyte-ratio-and-platelet-to-lymphocyte-ratio-are-effective-predictors-of-prognosis-in-patients-with-acute-mesenteric-arterial-embolism-and-thrombosis-short-title-nlr-plr-predict-the-prognosis-of-amae-amat
#10
Shuai Wang, Han Liu, Qi Wang, Zhihua Cheng, Siqiao Sun, Yang Zhang, Xiwei Sun, Zhongying Wang, Liqun Ren
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been shown to be valuable prognostic markers for a variety of pathological conditions including solid tumors, sepsis and others. However, the prognostic values of the NLR and PLR in patients with acute mesenteric arterial embolism (AMAE) and acute mesenteric arterial thrombosis (AMAT) have not been elucidated. The aim of this study was to determine the predictive value of the NLR and PLR for poor prognosis in patients with AMAE and AMAT...
February 8, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29427767/an-assessment-of-the-relationship-of-physical-activity-obesity-and-chronic-diseases-conditions-between-active-obese-and-sedentary-normal-weight-american-women-in-a-national-sample
#11
J R Pharr, C A Coughenour, T J Bungum
OBJECTIVE: Obesity and physical inactivity are associated with increased rates of chronic diseases and conditions. However, the 'fit but fat' theory posits that cardiopulmonary fitness (or physical activity) can mitigate risks to health associated with obesity. The purpose of this study was to compare chronic diseases and conditions of highly active/obese women with inactive/normal weight women. STUDY DESIGN: This was a cross-sectional study of the 2015 Behavioral Risk Factor Surveillance System data...
February 7, 2018: Public Health
https://www.readbyqxmd.com/read/29424751/lack-of-association-of-tumor-necrosis-factor-superfamily-member-4-tnfsf4-gene-polymorphisms-rs3850641-and-rs17568-with-coronary-heart-disease-and-stroke-a-systematic-review-and-meta-analysis
#12
Jin Sen Lu, Hong Wang, Fei Fei Yuan, Le Le Wu, Bin Wang, Dong Qing Ye
OBJECTIVE: To evaluate the association between the tumor necrosis factor superfamily member 4 (TNFSF4) gene polymorphisms and common cardiovascular and cerebrovascular diseases. METHODS: A literature-based search was conducted through databases including PubMed, EMBASE, Cochrane Library, CNKI, and WanFang data. Crude odds ratios (ORs) and 95% confidence intervals (CI) were calculated to estimate the strength of the association between TNFSF4 polymorphisms (rs3850641 and rs17568) and the risk of coronary heart disease (CHD) and stroke...
February 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29422279/comparison-of-in-hospital-outcomes-between-transcatheter-and-surgical-aortic-valve-replacement-in-patients-with-aortic-valve-stenosis-a-retrospective-cohort-study-using-administrative-data
#13
Takeshi Umegaki, Susumu Kunisawa, Yasufumi Nakajima, Takahiko Kamibayashi, Kiyohide Fushimi, Yuichi Imanaka
OBJECTIVE: The number of surgeries for valvular heart disease performed in Japan has greatly increased over the past decade, and surgical aortic valve replacements (SAVR) constitute the vast majority of aortic valve replacement procedures. Although transcatheter aortic valve implantation (TAVI) was recently introduced, studies have yet to compare the clinical outcomes between TAVI and SAVR in the Japanese healthcare setting. This study aimed to compare in-hospital outcomes between TAVI and SAVR using a multicenter administrative database...
June 30, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29420613/patient-reported-adherence-to-statin-therapy-barriers-to-adherence-and-perceptions-of-cardiovascular-risk
#14
Vicki Fung, Ilana Graetz, Mary Reed, Marc G Jaffe
BACKGROUND: Patient reports of their adherence behaviors, concerns about statins, and perceptions of atherosclerotic cardiovascular disease (ASCVD) risk could inform approaches for improving adherence to statin therapy. We examined these factors and their associations with adherence. METHODS: We conducted telephone interviews among a stratified random sample of adults receiving statins within an integrated delivery system (N = 730, 81% response rate) in 2010. We sampled equal numbers of individuals in three clinical risk categories: those with 1) coronary artery disease; 2) diabetes or other ASCVD diagnosis; and 3) no diabetes or ASCVD diagnoses...
2018: PloS One
https://www.readbyqxmd.com/read/29419859/-identification-of-22q11-2-microdeletion-among-patients-with-congenital-heart-diseases-using-droplet-digital-pcr
#15
Xiangcheng Zhou, Cuicui Zhang, Mi Li, Jian Ma, Qiuping Chen, Shanquan Sun, Liang Zhang
OBJECTIVE To develop a new method for detecting 22q11.2 deletion syndrome (22q11.2 DS) in clinical settings. METHODS Specific primers and fluorescence probes were designed to target the TBX1 gene within the 22q11.2 deletion region and a reference gene RPP30. Multiplexed droplet digital PCR (ddPCR) was run to detect the 22q11.2 microdeletion by calculating the ratio of positive droplet number of TBX1/RPP30. RESULTS Three cases of 22q11.2 microdeletion previously confirmed by array comparative genome hybridization were successfully identified...
February 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29419707/assessing-variation-in-implantable-cardioverter-defibrillator-therapy-guideline-adherence-with-physician-and-hospital-patient-sharing-networks
#16
Erika L Moen, Julie P Bynum, Andrea M Austin, Jonathan S Skinner, Gouri Chakraborti, Alistair James O'Malley
BACKGROUND: Implantable cardioverter defibrillator (ICD) therapy is used for primary prevention of death among people with heart failure, and new evidence in 2005 on its effectiveness changed practice guidelines in the United States. OBJECTIVES: The objective of this study is to examine how the connectedness of physicians and hospitals, measured using network analysis, relates to guideline-consistent ICD implantation. RESEARCH DESIGN: We constructed physician and hospital networks for cardiovascular disease...
February 6, 2018: Medical Care
https://www.readbyqxmd.com/read/29417316/body-mass-index-abdominal-fatness-and-the-risk-of-sudden-cardiac-death-a-systematic-review-and-dose-response-meta-analysis-of-prospective-studies
#17
Dagfinn Aune, Sabrina Schlesinger, Teresa Norat, Elio Riboli
Although overweight and obesity are established risk factors for some types of heart disease including ischemic heart disease, heart failure and atrial fibrillation, less is known about the association between adiposity and sudden cardiac death. We conducted a systematic review and meta-analysis of prospective studies to clarify the association between adiposity and risk of sudden cardiac death. PubMed and Embase databases were searched up to July 20th 2017. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated using random effects models...
February 7, 2018: European Journal of Epidemiology
https://www.readbyqxmd.com/read/29413372/low-dose-aspirin-in-heart-failure-not-complicated-by-atrial-fibrillation-a-nationwide-propensity-matched-study
#18
Christian Madelaire, Gunnar Gislason, Søren L Kristensen, Emil L Fosbøl, Jenny Bjerre, Maria D'Souza, Finn Gustafsson, Lars Kober, Christian Torp-Pedersen, Morten Schou
OBJECTIVES: This study sought to assess safety and effectiveness of low-dose aspirin in heart failure (HF) not complicated by atrial fibrillation. BACKGROUND: Despite lack of evidence, low-dose aspirin is widely used in patients with HF and sinus rhythm with and without prior ischemic heart disease. METHODS: The study included 12,277 patients with new-onset HF during 2007 to 2012 who had no history of atrial fibrillation. Of 5,450 patients using low-dose aspirin at baseline, 3,840 were propensity matched to non-aspirin users in a 1:1 ratio...
February 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29412239/association-of-multiple-genetic-variants-with-the-extension-and-severity-of-coronary-artery-disease
#19
Simone Cristina Pinto Matheus Fischer, Simone Pires Pinto, Lívia Campos do Amaral Silva Lins, Henrique Tria Bianco, Carlos Manoel de Castro Monteiro, Luiz Fernando Muniz Pinheiro, Francisco Antonio Helfenstein Fonseca, Maria Cristina de Oliveira Izar
BACKGROUND: Metabolic syndrome (MS) is a condition that, when associated with ischemic heart disease and cardiovascular events, can be influenced by genetic variants and determine more severe coronary atherosclerosis. OBJECTIVES: To examine the contribution of genetic polymorphisms to the extension and severity of coronary disease in subjects with MS and recent acute coronary syndrome (ACS). METHODS: Patients (n = 116, 68% males) aged 56 (9) years, with criteria for MS, were prospectively enrolled to the study during the hospitalization period after an ACS...
February 1, 2018: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29410832/prediction-of-cholesterol-ratios-within-a-korean-population
#20
Jin Sol Lee, Hyun Sub Cheong, Hyoung Doo Shin
Cholesterol ratios (total cholesterol (TC)/high-density lipoprotein cholesterol (HDL-c) and triglyceride (TG)/HDL-c) have been suggested as better indicators to predict various clinical features such as insulin resistance and heart disease. Therefore, we aimed to build a single nucleotide polymorphism (SNP) set to predict constitutional lipid metabolism. The genotype data of 7795 samples were obtained from the Korea Association Resource. Among the total of 7795 samples, 7016 subjects were used to perform 10-fold cross-validation...
January 2018: Royal Society Open Science
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