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JOURNAL ARTICLE
Julie Nyholm Kyvsgaard, Laura Marie Hesselberg, Rikke Bjersand Sunde, Nicklas Brustad, Nilo Vahman, Ann-Marie Malby Schoos, Klaus Bønnelykke, Jakob Stokholm, Bo Chawes
BACKGROUND: Early-life respiratory tract infections have been linked to the development of asthma, but studies on burden and subtypes of common infections in asthma development are sparse. OBJECTIVE: The study aimed to examine the association between burden of early-life infections, including subtypes, with risk of asthma from ages 3-10 years and lung function at age 10 years. METHODS: We included 662 children from the COPSAC2010 birth cohort, where infections, i...
April 10, 2024: Journal of Allergy and Clinical Immunology in Practice
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JOURNAL ARTICLE
Neda Mahavar, Masoud Asghari, Mohammadreza Mofatteh, Sanaz Jaberi, Nafiseh Erfanian, Mahboobeh Chahkandi, Mohammad Fereidouni
PURPOSE: Adenotonsillar hypertrophy (ATH) is a medical condition characterized by the enlargement or swelling of the tonsils. The role of allergy in ATH has not been persuasively evidenced. Therefore, we investigated the state of humoral immunity and the presence of specific immunoglobulin E (sIgE) in tissues and sera in children suffering from TH. METHODS: According to the skin prick test (SPT) result, 44 ATH children were divided into the atopic and non-atopic groups...
March 28, 2024: European Archives of Oto-rhino-laryngology
#3
Rehab Y Al-Ansari, Leena Abdulrahman Almuhaish, Khaled Abdullah Hassan, Tawasoul Fadoul, Alexander Woodman
BACKGROUND: A fixed drug eruption (FDE) is an immunological cutaneous adverse reaction, classified as a cutaneous adverse drug reaction (CADR) and characterized by well-defined lichenoid lesions that occur at the same site each time. Ceftriaxone is a third-generation antibiotic of cephalosporin antibiotics of the beta-lactam antibiotic family, which has typical in vitro activity against many Gram-negative aerobic bacteria. This is the first clinical case from Saudi Arabia and the fifth in the world to document a woman's experience with recurrent FDE after repeated ceftriaxone use...
2024: Case Reports in Dermatological Medicine
#4
JOURNAL ARTICLE
Francisca Cunha, Inês Cunha, Eva Gomes
BACKGROUND: Around 10% of people report a drug allergy and avoid some medications because of fear of allergic reactions. However, only after a proper diagnostic workup can some of these reactions be confirmed as allergic or nonallergic hypersensitivities. Beta-lactams (BLs) are the most common medication suspected of being involved in drug hypersensivity reactions (DHRs) in children. Recently, direct oral provocation tests (DPT) with BLs gained popularity within pediatric populations as a tool for delabeling children with suspected BL allergies...
2024: Allergologia et Immunopathologia
#5
JOURNAL ARTICLE
Ramon Massoni-Badosa, Sergio Aguilar-Fernández, Juan C Nieto, Paula Soler-Vila, Marc Elosua-Bayes, Domenica Marchese, Marta Kulis, Amaia Vilas-Zornoza, Marco Matteo Bühler, Sonal Rashmi, Clara Alsinet, Ginevra Caratù, Catia Moutinho, Sara Ruiz, Patricia Lorden, Giulia Lunazzi, Dolors Colomer, Gerard Frigola, Will Blevins, Lucia Romero-Rivero, Víctor Jiménez-Martínez, Anna Vidal, Judith Mateos-Jaimez, Alba Maiques-Diaz, Sara Ovejero, Jérôme Moreaux, Sara Palomino, David Gomez-Cabrero, Xabier Agirre, Marc A Weniger, Hamish W King, Lucy C Garner, Federico Marini, Francisco Javier Cervera-Paz, Peter M Baptista, Isabel Vilaseca, Cecilia Rosales, Silvia Ruiz-Gaspà, Benjamin Talks, Keval Sidhpura, Anna Pascual-Reguant, Anja E Hauser, Muzlifah Haniffa, Felipe Prosper, Ralf Küppers, Ivo Glynne Gut, Elias Campo, José Ignacio Martin-Subero, Holger Heyn
Palatine tonsils are secondary lymphoid organs (SLOs) representing the first line of immunological defense against inhaled or ingested pathogens. We generated an atlas of the human tonsil composed of >556,000 cells profiled across five different data modalities, including single-cell transcriptome, epigenome, proteome, and immune repertoire sequencing, as well as spatial transcriptomics. This census identified 121 cell types and states, defined developmental trajectories, and enabled an understanding of the functional units of the tonsil...
February 13, 2024: Immunity
#6
JOURNAL ARTICLE
Alexander David Barrow, Marina Cella, Melissa Anne Edeling, Md Abdullah-Al-Kamran Khan, Luisa Cervantes-Barragan, Mattia Bugatti, Christian Schmedt, William Vermi, Marco Colonna
NKp44 is a human receptor originally found on activated NK cells, group 1 and group 3 innate lymphoid cells that binds dimers of platelet-derived growth factor D (PDGF-DD). NKp44 is also expressed on tissue plasmacytoid dendritic cells (PDCs), but NKp44-PDGF-DD interaction on PDCs remains unstudied. Engagement of NKp44 with PDGF-DD in vitro enhanced PDC secretion of IFN-α, TNF, and IL-6 in response to the TLR9 ligand CpG-ODN, but not TLR7/8 ligands. In tissues, PDCs were found in close contact with PDGF-DD-expressing cells in the high endothelial venules and epithelium of tonsils, melanomas, and skin lesions infected with Molluscum contagiosum...
December 20, 2023: Journal of Immunology
#7
JOURNAL ARTICLE
Jia Song, Hai Wang, Zhe-Zheng Wang, Cui-Lian Guo, Wen-Xuan Xiang, Jing-Xian Li, Zhi-Chao Wang, Ji-Xin Zhong, Kun Huang, Robert P Schleimer, Yin Yao, Zheng Liu
BACKGROUND: Ectopic lymphoid tissues (eLTs) and the associated follicular helper T (TFH ) cells contribute to local immunoglobulin hyperproduction in nasal polyps (NPs). Follicular regulatory T (TFR ) cells in secondary lymphoid organs counteract TFH cells and suppress immunoglobulin production; however, the presence and function of TFR cells in eLTs in peripheral diseased tissues remain poorly understood. OBJECTIVE: To investigate the presence, phenotype, and function of TFR cells in NPs...
December 8, 2023: Journal of Allergy and Clinical Immunology
#8
JOURNAL ARTICLE
Julie Nyholm Kyvsgaard, Nicklas Brustad, Laura Marie Hesselberg, Nilo Vahman, Jonathan Thorsen, Ann-Marie Malby Schoos, Klaus Bønnelykke, Jakob Stokholm, Bo Lund Chawes
BACKGROUND: Risk factors of asthma-like symptoms in childhood may act through an increased infection burden as infections often trigger these symptoms. ObjectiveTo investigate whether the effect of established risk factors of asthma-like episodes in early childhood is mediated through burden and subtypes of common infections. METHODS: The study included 662 children from the COPSAC2010 mother-child cohort, where infections were registered prospectively in daily diaries at age 0-3 years...
November 21, 2023: Journal of Allergy and Clinical Immunology
#9
JOURNAL ARTICLE
Arthur Nery Finatto, Sulove Koirala, Fernanda Luiza Facioli, Jéssica Aparecida Barbosa, Roman Nosach, Matheus de Oliveira Costa
Streptococcus equi subsp. zooepidemicus is an emerging pathogen of pigs, resulting in high-mortality outbreaks of septicaemia and abortions. Here, we investigated the early pathogenesis of S. zooepidemicus in pigs following oronasal inoculation. Fourteen pigs were inoculated with live cultures of S. zooepidemicus ST-194, and monitored at 2,4, 8, and 24 h post-inoculation. Necropsies were performed to assess gross lesions and collect samples for bacterial culture and PCR analysis at each time point. Our findings revealed that S...
November 18, 2023: Comparative Immunology, Microbiology and Infectious Diseases
#10
JOURNAL ARTICLE
Safieh Zeinali, Kate Sutton, Lonneke Vervelde
Chickens exhibit a distinct immune architecture characterised by the absence of draining lymph nodes and the presence of a well-developed mucosa-associated lymphoid tissue. The structure and spatiotemporal development of chicken lymphoid tissues in the intestine are poorly documented. The macroscopically indistinct structure of chicken Peyer's patches has impeded studies into their development. The generation of CSF1R-eGFP reporter transgenic chickens enables visualisation of the development, organisation and extent of chicken lymphoid tissues by unique macroscopic views...
November 10, 2023: Developmental and Comparative Immunology
#11
JOURNAL ARTICLE
Ji-Hyeon Shin, Jeong-Bae Jeon, Min Chae Jeon, Sohee Park, Hyojung Kim
OBJECTIVES: The association between adenotonsillar hypertrophy (ATH) and allergies remains controversial. Periostin is an important player in allergic diseases. We aimed to investigate the expression of periostin in hypertrophic tonsils and adenoids in children. METHODS: We enrolled 24 children who underwent adenotonsillectomy due to sleep-disordered breathing. They were divided into atopic and control groups according to ImmunoCAP results. The presence and location of periostin in the tonsils and adenoids were determined by immunohistochemical staining...
August 25, 2023: International Journal of Pediatric Otorhinolaryngology
#12
JOURNAL ARTICLE
Anna Cutrina-Pons, Aloka De Sa, David J Fear, Hannah J Gould, Faruk Ramadani
Phosphoinositide 3-kinase (PI3K) p110δ signalling negatively regulates the production of mouse IgE. However, there are disparities between the mouse and human IgE biology, and the role of PI3K p110δ in the production of human IgE is yet to be determined. To investigate the effect of PI3K p110δ inhibition in the production of human IgE we isolated human B cells from tonsil tissue and stimulated them with IL-4 and anti-CD40 antibody to induce class switching to IgE and IgG1 in the presence or absence of IC87114, a small molecule inhibitor of PI3K p110δ...
August 2, 2023: Immunology
#13
JOURNAL ARTICLE
Alexander K C Leung, Joseph Lam, Benjamin Barankin, Kin Fon Leong, Kam Lun Hon
BACKGROUND: Group A ß-hemolytic streptococcus (GABHS) is the leading bacterial cause of acute pharyngitis in children and adolescents worldwide. OBJECTIVE: This article aims to familiarize clinicians with the clinical manifestations, evaluation, diagnosis, and management of GABHS pharyngitis. METHODS: A search was conducted in December 2022 in PubMed Clinical Queries using the key term "group A β-hemolytic streptococcal pharyngitis"...
July 26, 2023: Current Pediatric Reviews
#14
JOURNAL ARTICLE
Jenna M Kastenschmidt, Suhas Sureshchandra, Aarti Jain, Jenny E Hernandez-Davies, Rafael de Assis, Zachary W Wagoner, Andrew M Sorn, Mahina Tabassum Mitul, Aviv I Benchorin, Elizabeth Levendosky, Gurpreet Ahuja, Qiu Zhong, Douglas Trask, Jacob Boeckmann, Rie Nakajima, Algimantas Jasinskas, Naresha Saligrama, D Huw Davies, Lisa E Wagar
Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To advance informed vaccine design, it is critical that we understand the cellular dynamics underlying responses to different antigen formats. Here, we sought to understand how antigen-specific B and T cells were activated and participated in adaptive immune responses within the mucosal site. Using a human tonsil organoid model, we tracked the differentiation and kinetics of the adaptive immune response to influenza vaccine and virus modalities...
August 8, 2023: Immunity
#15
JOURNAL ARTICLE
Joshua D Brandstadter, Angelina De Martin, Mechthild Lϋtge, Antonio Ferreira, Brian T Gaudette, Yves Stanossek, Shumei Wang, Michael V Gonzalez, Edward Camiolo, Gerald Wertheim, Bridget Austin, David Allman, Adam Bagg, Megan S Lim, David C Fajgenbaum, Jon C Aster, Burkhard Ludewig, Ivan Maillard
Nonhematopoietic lymph node stromal cells (LNSCs) regulate lymphocyte trafficking, survival, and function for key roles in host defense, autoimmunity, alloimmunity, and lymphoproliferative disorders. However, the study of LNSCs in human diseases is complicated by a dependence on viable lymphoid tissues, which are most often excised prior to establishment of a specific diagnosis. Here, we demonstrate that cryopreservation can be used to bank lymphoid tissue for the study of LNSCs in human disease. Using human tonsils and lymph nodes (LN), lymphoid tissue fragments were cryopreserved for subsequent enzymatic digestion and recovery of viable nonhematopoietic cells...
June 27, 2023: European Journal of Immunology
#16
JOURNAL ARTICLE
Byeonghwi Lim, Seung-Chai Kim, Won-Il Kim, Jun-Mo Kim
Porcine reproductive and respiratory syndrome virus (PRRSV) infection severely affects the swine industry each year. Although the host mechanisms against PRRSV infection have been identified in key target tissues through whole transcriptome sequencing, specific molecular regulators have not been elucidated. Long non-coding RNA (lncRNA) expression is highly specific and could thus be used to effectively identify PRRSV-specific candidates. Here, we identified novel lncRNAs in lungs, bronchial lymph nodes, and tonsils after PRRSV infection and constructed phenotype-based integrative co-expression networks using time-series differentially expressed (DE) lncRNAs and mRNAs...
June 12, 2023: Developmental and Comparative Immunology
#17
JOURNAL ARTICLE
Zheng Gu, Ping Wei, Wei Kou, Xin-Ye Tang, Hong-Bing Yao, En-Mei Liu
INTRODUCTION: Allergic rhinitis (AR) in children is associated with various comorbidities, posing challenges for treatment and management. There have been few investigations of these multimorbidities in Chinese children with AR. Here, we investigated the prevalence of multimorbidities in children with moderate to severe AR and analyzed the influencing factors using real-world data. METHODS: In total, 600 children who visited the outpatient clinic of our hospital and were diagnosed with moderate-severe AR were prospectively enrolled...
June 8, 2023: International Archives of Allergy and Immunology
#18
JOURNAL ARTICLE
Anoma Nellore, Esther Zumaquero, Christopher D Scharer, Christopher F Fucile, Christopher M Tipton, R Glenn King, Tian Mi, Betty Mousseau, John E Bradley, Fen Zhou, Stuti Mutneja, Paul A Goepfert, Jeremy M Boss, Troy D Randall, Ignacio Sanz, Alexander F Rosenberg, Frances E Lund
Seasonal influenza vaccination elicits hemagglutinin (HA)-specific memory B (Bmem) cells, and although multiple Bmem cell populations have been characterized, considerable heterogeneity exists. We found that HA-specific human Bmem cells differed in the expression of surface marker FcRL5 and transcriptional factor T-bet. FcRL5+ T-bet+ Bmem cells were transcriptionally similar to effector-like memory cells, while T-betneg FcRL5neg Bmem cells exhibited stem-like central memory properties. FcRL5+ Bmem cells did not express plasma-cell-commitment factors but did express transcriptional, epigenetic, metabolic, and functional programs that poised these cells for antibody production...
March 16, 2023: Immunity
#19
JOURNAL ARTICLE
Wenjing Chen, Guoping Yin, Yijing Chen, Lijun Wang, Yingying Wang, Chunmei Zhao, Wan Wang, Jingying Ye
OBJECTIVE: Adenoid hypertrophy (AH) and otitis media with effusion (OME) are common pediatric otolaryngological diseases and often occur concurrently. The purpose of this study was to comprehensively analyze the factors that influence the occurrence of OME pediatric patients with AH. METHODS: Patients younger than 12 years with AH, who were hospitalized for treatment at Beijing Tsinghua Changgung Hospital in Beijing, China, between March 2018 and February 2022 were enrolled...
2023: Frontiers in Pediatrics
#20
JOURNAL ARTICLE
Yang Mei, Yue Xin, Xi Li, Heng Yin, Feng Xiong, Ming Yang, Haijing Wu
Systemic lupus erythematosus (SLE) is a typical autoimmune disease distinguished by multiple organ dysfunction, which is related to a variety of causative factors. B-cell overactivation is a key factor in SLE. However, the pathogenesis underlying anomalous B cells has not been well elucidated. B-cell fate is regulated in diverse epigenetic ways apart from traditional ways. As one of the mechanisms of epigenetics, histone modification mainly affects transcription and translation by changing the chemical groups on histones by histone modification enzymes...
March 2023: Immunobiology
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