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https://www.readbyqxmd.com/read/28351052/diabetic-macular-edema
#1
Francesco Bandello, Maurizio Battaglia Parodi, Paolo Lanzetta, Anat Loewenstein, Pascale Massin, Francesca Menchini, Daniele Veritti
Diabetic macular edema (DME), defined as a retinal thickening involving or approaching the center of the macula, represents the most common cause of vision loss in patients affected by diabetes mellitus. In the last few years, many diagnostic tools have proven to be useful in the detection and the monitoring of the features characterizing DME. On the other hand, several therapeutic approaches can now be proposed on the basis of the DME-specific characteristics. The aim of the present chapter is to thoroughly delineate the clinical and morphofunctional characteristics of DME and its current treatment perspectives...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351047/postsurgical-cystoid-macular-edema
#2
Dinah Zur, Anat Loewenstein
Cystoid macular edema (CME) is a primary cause of reduced vision following both cataract and successful vitreoretinal surgery. The incidence of clinical CME following modern cataract surgery is 0.1-2.35%. Preexisting conditions such as diabetes mellitus and uveitis as well as intraoperative complications can raise the risk of postsurgical CME. The etiology of CME is not completely understood. Prolapsed or incarcerated vitreous and postoperative inflammatory processes have been proposed as causative agents. Pseudophakic CME is characterized by poor postoperative visual acuity...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351019/online-microdialysis-ultra-performance-liquid-chromatography-mass-spectrometry-method-for-comparative-pharmacokinetic-investigation-on-iridoids-from-gardenia-jasminoides-ellis-in-rats-with-different-progressions-of-type-2-diabetic-complications
#3
Xueju Zhang, Lu Wang, Zhong Zheng, Zifeng Pi, Zhiqiang Liu, Fengrui Song
Iridoid glycosides consist the main bioactive constituents of Gardenia jasminoides Ellis (G. jasminoides), which is used alone or in combination with other medicine herbs for treatment of diabetes mellitus in China. This paper investigated for the first time comparative pharmacokinetics (PKs) of four unbound iridoids (including genipin, geniposide, gardenoside and geniposidic acid) in rat blood between healthy and type 2 diabetic groups with different disease progressions (9 or 13 weeks). Online microdialysis-ultra performance liquid chromatography-mass spectrometry (MD- UPLC-MS/MS) method was used after oral administration of iridoid extracts obtained from the fruits of G...
March 21, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28350839/bidirectional-association-between-nonalcoholic-fatty-liver-disease-and-type-2-diabetes-in-chinese-population-evidence-from-the-dongfeng-tongji-cohort-study
#4
Yaru Li, Jing Wang, Yuhan Tang, Xu Han, Bing Liu, Hua Hu, Xiulou Li, Kun Yang, Jing Yuan, Xiaoping Miao, Ping Yao, Sheng Wei, Youjie Wang, Yuan Liang, Xiaomin Zhang, Huan Guo, An Pan, Handong Yang, Frank B Hu, Tangchun Wu, Meian He
OBJECTIVES: The aim of this study is to examine the bidirectional association between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM). METHODS: The data was derived from the Dongfeng-Tongji cohort study, which was established in 2008 and followed until October 2013. NAFLD was classified as none, mild, moderate/severe based on ultrasound examination. The analysis to examine the association between NAFLD and incident T2DM risk included 18,111 participants free of diabetes at baseline and the duration of follow-up was 4...
2017: PloS One
https://www.readbyqxmd.com/read/28350823/cluster-analysis-to-estimate-the-risk-of-preeclampsia-in-the-high-risk-prediction-and-prevention-of-preeclampsia-and-intrauterine-growth-restriction-predo-study
#5
Pia M Villa, Pekka Marttinen, Jussi Gillberg, A Inkeri Lokki, Kerttu Majander, Maija-Riitta Ordén, Pekka Taipale, Anukatriina Pesonen, Katri Räikkönen, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori
OBJECTIVES: Preeclampsia is divided into early-onset (delivery before 34 weeks of gestation) and late-onset (delivery at or after 34 weeks) subtypes, which may rise from different etiopathogenic backgrounds. Early-onset disease is associated with placental dysfunction. Late-onset disease develops predominantly due to metabolic disturbances, obesity, diabetes, lipid dysfunction, and inflammation, which affect endothelial function. Our aim was to use cluster analysis to investigate clinical factors predicting the onset and severity of preeclampsia in a cohort of women with known clinical risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/28350539/personalized-precision-medicine-in-extreme-preterm-infants-with-transient-neonatal-diabetes-mellitus
#6
Ranjit I Kylat, Rajan Senguttuvan, Mohammed Y Bader
Although hyperglycemia is common in neonates, especially preterm infants, a diagnosis of neonatal diabetes mellitus (NDM) is rarely made. NDM can be permanent (45%), transient (45%) or syndromic (10%). Of the 95% of identifiable mutations for NDM, methylation defects in 6q24, KCNJ11, ABCC8, and INS account for the majority. Two cases of transient NDM in extremely preterm, 24 weeks' gestational age (GA) triplets, due to a missense mutation c.685G>A in the KCNJ11 gene are presented. Both patients were successfully transitioned from insulin to Glyburide (Glibenclamide) at 2 months of age...
March 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28346859/circulating-zbed3-levels-in-subjects-with-and-without-metabolic-syndrome
#7
Wenjing Hu, Bo Tian, Xiaoqiang Li, Ling Li, Lin Zhang, Hua Liu, Gangyi Yang, Yongsheng Liu, Xiaoyun Fan
BACKGROUND: Zinc-finger BED domain-containing 3 (Zbed3) is a member of the zinc-finger domain protein superfamily. Recent studies have shown that Zbed3 is associated with insulin resistance and type 2 diabetes mellitus. However, no report has demonstrated the association of Zbed3 with metabolic syndrome (MetS) in humans. The purpose of this study is to examine the association between Zbed3 and MetS in a cross-sectional study. METHODS: We conducted a cross-sectional study of a Chinese population, including 167 non-MetS subjects and 144 newly diagnosed MetS (nMetS) patients...
March 27, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28346753/association-between-diabetes-mellitus-hyperglycemia-and-peri-implant-diseases-systematic-review-and-meta-analysis
#8
REVIEW
Alberto Monje, Andres Catena, Wenche S Borgnakke
AIM: This systematic review investigates whether hyperglycemia/diabetes mellitus is associated with peri-implant diseases (peri-implant mucositis and peri-implantitis). MATERIALS AND METHODS: Electronic and manual literature searching was conducted. An a priori case definition for peri-implantitis was used as an inclusion criterion to minimize risk of bias. The Newcastle Ottawa Scale was used for quality assessment; random effect models were applied; and results were reported according to the PRISMA Statement...
March 27, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28346567/effect-of-a-low-glycemic-index-mediterranean-diet-on-non-alcoholic-fatty-liver-disease-a-randomized-controlled-clinici-trial
#9
G Misciagna, M Del Pilar Díaz, D V Caramia, C Bonfiglio, I Franco, M R Noviello, M Chiloiro, D I Abbrescia, A Mirizzi, M Tanzi, M G Caruso, M Correale, R Reddavide, R Inguaggiato, A M Cisternino, A R Osella
INTRODUCTION: Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common form of liver disease worldwide affecting all ages and ethnic groups and it has become a consistent threat even in young people. Our aim was to estimate the effect of a Low Glycemic Index Mediterranean Diet (LGIMD) on the NAFLD score as measured by a Liver Ultrasonography (LUS). DESIGN: NUTRIzione in EPAtologia (NUTRIEPA) is a population-based Double-Blind RCT. Data were collected in 2011 and analyzed in 2013-14...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28346386/a-mixed-methods-examination-of-physical-activity-and-sedentary-time-in-overweight-and-obese-south-asian-men-living-in-the-united-kingdom
#10
Amir Emadian, Janice Thompson
South Asian men living in the UK have higher rates of central obesity and Type 2 Diabetes Mellitus (T2DM) compared with their white British counterparts. Physical activity (PA) and sedentary time (ST) are important risk factors for the development of T2DM. The purpose of this study was to objectively measure PA, ST, and to explore the factors influencing these behaviours in this high-risk population. A mixed-methods cross-sectional research design was employed, including the quantification of PA and ST using the self-report International Physical Activity Questionnaire (IPAQ)-long form and accelerometry in overweight and obese UK South Asian men (n = 54), followed by semi-structured interviews in a purposive sub-sample to explore the factors influencing PA and ST (n = 31)...
March 27, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28346285/effect-of-early-revascularization-on-outcomes-in-diabetic-patients-with-stable-ischemic-heart-disease-and-previous-myocardial-infarction-in-the-bypass-angioplasty-investigation-2-diabetes-trial
#11
Matthew J Chung, Eric Novak, David L Brown
BACKGROUND: Survivors of a myocardial infarction (MI) are at a considerable risk of developing further cardiovascular events, including recurrent MI, heart failure, stroke, and death. Patients with type 2 diabetes mellitus and stable ischemic heart disease (SIHD) have worse outcomes than their nondiabetic counterparts, and those with previous MI may be at particularly high risk. Yet, little is known about the effect of adding early revascularization to intensive medical therapy in this high-risk group...
March 24, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28346279/sub-basal-corneal-nerve-plexus-analysis-using-a-new-software-technology
#12
Hatim Batawi, Nabeel Shalabi, Madhura Joag, Tulay Koru-Sengul, Jorge Rodriguez, Parke T Green, Mauro Campigotto, Carol L Karp, Anat Galor
PURPOSE: To study sub-basal corneal nerve plexus (SCNP) parameters by in vivo corneal confocal microscopy using a new software technology and examine the effect of demographics and diabetes mellitus (DM) on corneal nerves morphology. METHODS: A Confoscan 4 (Nidek Technologies) was used in this cross-sectional study to image the SCNP in 84 right eyes at the Miami Veterans Affairs eye clinic. Images were analyzed using a new semiautomated nerve analysis software program (The Corneal Nerve Analysis tool) which evaluated 9 parameters including nerve fibers length (NFL) and nerve fibers length density (NFLD)...
March 24, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28345986/children-and-young-people-with-diabetes-recognition-and-management
#13
Hamish Hamilton, Grace Knudsen, Camelia Laura Vaina, Michelle Smith, Siba Prosad Paul
Diabetes mellitus (type 1) is an autoimmune condition leading to absolute insulin deficiency resulting in hyperglycaemia and its associated manifestations. It is the most common type of diabetes seen in children, characterised by the 4Ts (toilet, thinner, thirsty, tired). The signs and symptoms can sometimes be non-specific and a delay or missed diagnosis may be catastrophic to the health of the child. Children with an established diagnosis of diabetes often present to the health service with issues such as hypoglycaemia, hyperglycaemia, or diabetic ketoacidosis...
March 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28345969/foot-ulceration-in-patients-with-diabetes-a-risk-analysis
#14
Mariana Angela Rossaneis, Maria do Carmo Fernandez Lourenço Haddad, Maria de Fátima Mantovani, Sonia Silva Marcon, Paloma de Souza Cavalcante Pissinati
The study reported in this article aimed to analyse factors associated with the risk of ulceration in the feet of patients with diabetes using a conceptual hierarchic model. It was a cross-sectional study carried out with 1515 people with diabetes mellitus aged 40 years and older. The risk of foot ulceration was of higher significance in male patients with diabetes (adjusted odds ratio (OR)=1.39 (95% confidence interval (CI) 1.11 to 1.73); p=0.020), who did not practise a regular physical activity (adjusted OR=1...
March 23, 2017: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/28345809/effect-of-lorcaserin-on-glycemic-parameters-in-patients-with-type-2-diabetes-mellitus
#15
Faidon Magkos, Elena Nikonova, Randi Fain, Sharon Zhou, Tony Ma, William Shanahan
OBJECTIVE: Lorcaserin, a 5-HT2C receptor agonist approved for chronic weight management, is also associated with improvements in glycemic parameters in patients with/without type 2 diabetes mellitus (T2DM), but the extent to which these effects are mediated by weight loss is unknown. This post hoc analysis further examines glycemic data from the Phase III BLOOM-DM study stratified by weight changes. METHODS: Patients with T2DM were randomized to lorcaserin 10 mg twice daily or placebo...
March 27, 2017: Obesity
https://www.readbyqxmd.com/read/28345543/use-of-first-phase-insulin-secretion-in-early-diagnosis-of-thyroid-diabetes-and-type-2-diabetes-mellitus
#16
Li-Heng Meng, Yao Huang, Jia Zhou, Xing-Huan Liang, Jing Xian, Li Li, Ying-Fen Qin
BACKGROUND: A relationship between hyperthyroidism and insulin secretion in type 2 diabetes mellitus (T2DM) has been reported. Therefore, this study explored the use of first-phase insulin secretion in the differential diagnosis of thyroid diabetes (TDM) and T2DM. METHODS: In total, 101 patients with hyperthyroidism were divided into hyperthyroidism with normal glucose tolerance (TNGT), hyperthyroidism with impaired glucose regulation (TIGR), and diabetes (TDM) groups...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28345539/admission-glucose-and-in-hospital-mortality-after-acute-myocardial-infarction-in-patients-with-or-without-diabetes-a-cross-sectional-study
#17
Shi Zhao, Karthik Murugiah, Na Li, Xi Li, Zi-Hui Xu, Jing Li, Chen Cheng, Hong Mao, Nicholas S Downing, Harlan M Krumholz, Li-Xin Jiang
BACKGROUND: Hyperglycemia on admission has been found to elevate risk for mortality and adverse clinical events after acute myocardial infarction (AMI), but there are evidences that the relationship of blood glucose and mortality may differ between diabetic and nondiabetic patients. Prior studies in China have provided mixed results and are limited by statistical power. Here, we used data from a large, nationally representative sample of patients hospitalized with AMI in China in 2001, 2006, and 2011 to assess if admission glucose is of prognostic value in China and if this relationship differs depending on the presence or absence of diabetes...
April 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28345434/effect-of-diabetes-treatment-related-attributes-on-costs-to-type-2-diabetes-patients-in-a-real-world-population
#18
Jie Meng, Roman Casciano, Yi-Chien Lee, Lee Stern, Dmitry Gultyaev, Liyue Tong, Brice Kitio-Dschassi
BACKGROUND: Type 2 diabetes mellitus (T2DM) results in a substantial economic burden on patients, health care systems, and society. Most literature assessing the cost of T2DM focuses on the long-term complications of the disease, the association between glucose control and cost, and patient characteristics resulting in poor and costly outcomes. However, it is likely that attributes specific to diabetes therapy can affect the use of costly resources. OBJECTIVE: To estimate the effect of diabetes treatment-related attributes, such as improved efficacy, adherence, and reduced risk for hypoglycemia, on costs to T2DM patients...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28345395/evaluation-of-the-predictive-value-of-cha2ds2-vasc-score-for-in-stent-restenosis
#19
Samet Yilmaz, Mehmet Kadri Akboga, Dursun Aras, Serkan Topaloglu
The CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, previous stroke, vascular disease, age 65-74 years, female gender) score is used to estimate thromboembolic risk in atrial fibrillation (AF). Its usefulness in predicting in-stent restenosis (ISR) is unknown. We evaluated the predictive value of the CHA2DS2-VASc score in AF-free patients who have undergone stent implantation. A total of 1350 patients who underwent coronary angiography and successful bare-metal stent implantation were analyzed...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28345319/vascular-cell-adhesion-molecule-1-intercellular-adhesion-molecule-1-and-cluster-of-differentiation-146-levels-in-patients-with-type-2-diabetes-with-complications
#20
F Sinem Hocaoglu-Emre, Devrim Saribal, Guven Yenmis, Guvenc Guvenen
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a multisystemic, chronic disease accompanied by microvascular complications involving various complicated mechanisms. Intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and cluster of differentiation-146 (CD146) are mainly expressed by endothelial cells, and facilitate the adhesion and transmigration of immune cells, leading to inflammation. In the present study, we evaluated the levels of soluble adhesion molecules in patients with microvascular complications of T2DM...
March 2017: Endocrinology and Metabolism
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