Read by QxMD icon Read

Diabetes mellitus

Jian-Jun Liu, Sylvia Liu, Resham L Gurung, Keven Ang, Wern Ee Tang, Chee Fang Sum, Subramaniam Tavintharan, Su Chi Lim
Background: The progression trajectory of renal filtration function has not been well characterized in patients with early-onset type 2 diabetes mellitus (T2DM) although albuminuria is often reported in this population. We aim to study the risk of progressive chronic kidney disease (CKD) in individuals with early-onset T2DM. Methods: In total, 1189 T2DM participants were followed for 3.9 (interquartile range 3.2-4.7) years. Progressive CKD was defined as estimated glomerular filtration rate (eGFR) decline of ≥5 mL/min/1...
July 10, 2018: Nephrology, Dialysis, Transplantation
Jinjin Cui, Fengyun Zhang, Wei Cao, Yongshun Wang, Jingjin Liu, Xinxin Liu, Tao Chen, Ling Li, Jinwei Tian, Bo Yu
BACKGROUND: Erythropoietin (EPO), which is clinically used for renal anaemia, reportedly exerts beneficial pleiotropic effects in atherosclerosis. This aim of this study was to investigate the effects of EPO on macrophage inflammation and polarization under hyperglycaemic conditions and to identify the effects of EPO-treated macrophage supernatants (SNs) on endothelial cell (EC) function. METHODS: Peritoneal macrophages (pMΦs) were isolated from normal, diabetic or EPO-injected mice...
July 11, 2018: Molecular Immunology
Antonio Zanghì, Maria Di Vita, Antonio Borzì, Andrea Cavallaro, Francesco Cardì, Alessia Giaquinta, Emanuele Lo Menzo, Alessandro Cappellani
INTRODUCTION: Some factors may affect the conversion to open of the laparoscopic treatment of incisional hernia. Their presence can help to choose the most appropriate technique identifying patients at high risk conversion. METHODS: A retrospective study has been performed on a cohort of 306 patients, selected among those undergone to elective laparoscopic surgery for post incisional hernia between 2005 and 2015. Only symptomatic patients with single site wall defect, diameter between 5 and 10 cm, ASA ≤3, have been included...
April 28, 2018: Annali Italiani di Chirurgia
Lauren B Beach, Blair Turner, Dylan Felt, Rachel Marro, Gregory L Phillips
Low physical activity (PA), high sedentary behavior (SB), and overweight and obesity have been shown to associate with increased Type 2 diabetes risk among adolescents. We investigated PA, SB, and overweight and obesity among Youth Risk Behavior Survey (YRBS) respondents to determine if non-heterosexual youth may be at increased diabetes risk compared to heterosexual youth. Weighted city and state YRBS data were pooled across 44 jurisdictions biennially from 2009-2015, resulting in a sample size of 350,673 students...
July 13, 2018: Pediatric Diabetes
Toshihide Shima, Hirofumi Uto, Kohjiro Ueki, Yutaka Kohgo, Kohichiroh Yasui, Naoto Nakamura, Tatsuaki Nakatou, Toshinari Takamura, Sumio Kawata, Kazuo Notsumata, Kyoko Sakai, Ryosuke Tateishi, Takeshi Okanoue
BACKGROUND: We reported a cross-sectional study on causes of liver injury in Japanese type 2 diabetes mellitus (T2D) patients (JG 2013). We assessed overall and cause-specific mortality risk during follow-up of patients enrolled in JG 2013. METHODS: This was a longitudinal, multicenter cohort study. Of the 5642 Japanese T2D patients who visited T2D clinics of nine hospitals in the original study, 3,999 patients were followed up for an average of 4.5 years. Expected deaths in T2D patients were estimated using age-specific mortality rates in the general population (GP) of Japan...
July 13, 2018: Journal of Gastroenterology
O V Kokorev, V N Khodorenko, S G Anikeev, V E Gunter
The dynamics of the development of the pancreatic islet cells in the porous TiNi scaffold was studied by electron microscopy. Changes in the metabolism of glucose and glycosylated hemoglobin and parameters of the peripheral blood and bone marrow were shown after transplantation of pancreatic islet cells on porous permeable TiNi scaffold during alloxan-induced diabetes. The cells administered on the porous biocompatible scaffold produced more prolonged anti-diabetic effect and normalized hemopoiesis parameters in comparison with their intraperitoneal administration...
July 13, 2018: Bulletin of Experimental Biology and Medicine
Tomoyo Sugiyama, Erika Yamamoto, Krzysztof Bryniarski, Lei Xing, Francesco Fracassi, Hang Lee, Ik-Kyung Jang
BACKGROUND: Diabetes mellitus (DM) is a major risk factor for cardiovascular events. We aimed to investigate the coronary plaque phenotype of diabetic patients who presented with acute coronary syndromes by optical coherence tomography. METHODS AND RESULTS: A total of 322 patients with acute coronary syndromes who underwent preintervention optical coherence tomography imaging of the culprit lesion were included. Culprit plaque characteristics were compared between patients with DM (n=95) and those without DM (n=227)...
July 13, 2018: Journal of the American Heart Association
Sayuri Tanaka, Ippei Kanazawa, Toshitsugu Sugimoto
OBJECTIVE: Accumulating evidence has shown that sphingosine-1-phosphate (S1P) plays roles in glucose and fat metabolism. However, the association between plasma S1P levels and fat mass, especially visceral fat mass, remains unknown. METHODS: In this cross-sectional study, 80 men with type 2 diabetes mellitus (T2DM) were recruited to investigate the association of plasma S1P levels with body fat parameters. Visceral (VFA) and subcutaneous fat (SFA) areas were evaluated by performing computed tomography scan, and fat mass (FM) and lean body mass (LBM) were examined by whole body dual-energy X-ray absorptiometry...
July 10, 2018: Diabetes Research and Clinical Practice
Mohammad Javad Zare Sakhvidi, Fariba Zare Sakhvidi, Amir Houshang Mehrparvar, Maria Foraster, Payam Dadvand
BACKGROUND: The prevalence of diabetes is on rise worldwide and environmental factors are being increasingly recognized to be involved in this rise. An emerging body of evidence has evaluated the impact of long-term exposure to noise on diabetes mellitus, highlighting the need to synthesize this evidence. OBJECTIVES: To systematically review and conduct meta-analysis of the available evidence on the association between long-term exposure to transport and occupational noise exposure and diabetes mellitus...
July 10, 2018: Environmental Research
Hiroki Fujieda, Masakazu Kogami, Masao Sakairi, Noriyasu Kato, Mitsuhiro Makino, Naoki Takahashi, Toshiyuki Miyazawa, Satoko Harada, Tokuyuki Yamashita
Glucokinase (GK) is an enzyme that plays an important role as a glucose sensor while maintaining whole body glucose homeostasis. Allosteric activators of GK (GKAs) have the potential to treat type 2 diabetes mellitus. To identify novel GKAs, a series of compounds based on a thiophenyl-pyrrolidine scaffold were designed and synthesized. In this series, compound 38 was found to inhibit glucose excursion in an oral glucose tolerance test (OGTT) in mice. Optimization of 38 using a zwitterion approach led to the identification of the novel GKA 59...
June 26, 2018: European Journal of Medicinal Chemistry
Salamet Edirs, Lan Jiang, XueLei Xin, Haji Akber Aisa
Kursi Wufarikun Ziyabit (KWZ) is a traditional prescription that used in folk tea drinking for its health care effect in treatment of type 2 diabetes mellitus (T2DM) in central Asia. However, the underlying mechanism of KWZ in T2DM has not been investigated extensively. This study designed to observe the effect of KWZ on glucose consumption and assess the molecular mechanism on associated proteins in insulin signaling and ER stress pathway in L6 rat skeletal muscle cells. The results showed that, KWZ exhibited proteins of PTP-1B and α-glycosidase inhibitory activity in vitro...
June 21, 2018: Journal of Pharmacological Sciences
Thomas R Einarson, Annabel Acs, Craig Ludwig, Ulrik H Panton
BACKGROUND: Cardiovascular diseases (CVDs) constitute major comorbidities in type 2 diabetes mellitus (T2DM), contributing substantially to treatment costs for T2DM. An updated overview of the economic burden of CVD in T2DM has not been presented to date. OBJECTIVE: To systematically review published articles describing the costs associated with treating CVD in people with T2DM. METHODS: Two reviewers searched MEDLINE, Embase, and abstracts from scientific meetings to identify original research published between 2007 and 2017, with no restrictions on language...
July 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Jayaweera Arachchige Asela Sampath Jayaweera, Anpalaham Joseph
OBJECTIVES: Military personnel, because of the unique nature of their duties, are reluctant to face stressors. Living in hot and humid conditions they frequently suffer dehydration. Army soldiers living in dry zone of Sri Lanka, were screened for chronic kidney disease (CKD), common non-communicable diseases and methicillin resistant Staphylococcus aureus (MRSA) colonization. Albumin creatinine ratio > 30 mg/g urine taken as cut-off for detection of CKD. RESULTS: Screened 417 soldiers, all were men and body mass index were 21...
July 13, 2018: BMC Research Notes
Ryohei Ono, Hiroyuki Kashiwagi, Jun Kawachi, Naoko Isogai, Katsunori Miyake, Takaaki Murata, Rai Shimoyama, Ryuta Fukai, Hidemitsu Ogino, Nobuaki Shinozaki
INTRODUCTION: Liver gas gangrene is rare and has a low prognosis. This case, reports a successful treatment of hepatic gas gangrene using an open drainage technique, followed by antibiotics and hyperbaric oxygen therapy (HBO). PRESENTATION OF THE CASE: An 82-year-old male with a history of left hepatectomy and bile duct resection for hilar cholangiocarcinoma presented with chilling, lethargy and dyspnea. He had a history of diabetes mellitus, hypertension, atrial fibrillation, and angina pectoris...
June 30, 2018: International Journal of Surgery Case Reports
Siqi Ge, Youxin Wang, Manshu Song, Xingang Li, Xinwei Yu, Hao Wang, Jing Wang, Qiang Zeng, Wei Wang
Increased fasting plasma glucose (FPG) is an independent risk factor for type 2 diabetes mellitus (T2DM). The development of systems biology technologies for integration of multiomics data is crucial for predicting increased FPG levels. In this case-control study, immunoglobulin (Ig) G glycosylation profiling and genome-wide association analyses were performed on 511 participants, and among them 76 had increased FPG (aged 47.6 ± 6.14 years), and 435 had decreased or fluctuant FPG (aged 47.9 ± 6.08 years)...
July 2018: Omics: a Journal of Integrative Biology
Nishanth Vallumsetla, Lisa Epp, Ryan T Hurt, Manpreet S Mundi
BACKGROUND: Diabetes mellitus (DM) is estimated to affect 9% of Americans and is associated with significant morbidity, mortality, and increased healthcare costs. METHODS: A retrospective review of a home enteral nutrition (HEN) database of patients seen between March 1, 2004, and April 31, 2014, at our institution was conducted to identify HEN patients who had a diagnosis of DM or were diagnosed within the acute period (4 months) of starting HEN therapy. RESULTS: 174 (3...
July 13, 2018: Nutrition in Clinical Practice
Mohammad Bagheri, Abdollah Amini, Mohammad-Amin Abdollahifar, Seyed Kamran Ghoreishi, Abbas Piryaei, Ramin Pouriran, Sufan Chien, Sara Dadras, Fatemehalsadat Rezaei, Mohammad Bayat
BACKGROUND: A lack of effective treatments still exists for patients suffering from diabetes mellitus. Photobiomodulation is proved as a beneficial therapeutic modality for wounds. OBJECTIVE: The aim of this study is to examine the effect of degranulation of mast cells and total number of mast cells in the remodeling step of an ischemic model of wound healing under the influence of photobiomodulation and conditioned medium (CM) from human bone marrow-derived mesenchymal stem cells (hBM-MSCs-CM), or CM, administered alone and or in combination...
July 6, 2018: Photomedicine and Laser Surgery
Geysa Maria Nogueira Farias, José Reginaldo Pinto, Juliana Carneiro Melo, Lara Gurgel Fernandes Távora, Danielle Malta Lima, Fernanda Judith Viana Correia, Geraldo Bezerra da Silva Júnior
Kyrle's disease (KD) is a rare skin pathology characterized by transepidermal elimination of abnormal keratin. The aim of this article is to report a rare case of KD associated with diabetes mellitus, chronic kidney disease, and HIV. A 51-year-old male patient complained of diarrhea for 8 months. He was submitted to HIV testing, which showed a positive result. He started antiretroviral therapy with zidovudine, lamivudine, and lopinavir. The diagnostic investigation was negative for opportunistic diseases. After 2 months, skin lesions started appearing, characterized by hyperchromic, pruritic macules and papules distributed in the trunk, back, and upper limbs...
July 2018: Indian Journal of Pathology & Microbiology
Junling Liu, Kun Yang, Wenhua Xiao, Yunyi Le, Shan Lang, Jingjing Zhang, Rui Wei, Jin Yang, Tianpei Hong
The level of serum angiopoietin-like protein 8 (ANGPTL8), a novel hepatokine, is associated with obesity and type 2 diabetes mellitus (T2DM). To investigate whether serum ANGPTL8 level in patients with T2DM was affected by treatment with exenatide, a glucagon-like peptide-1 receptor (GLP-1R) agonist, and to determine whether and how GLP-1R agonists regulated ANGPTL8 production in hepatocytes. A multiple-center trial was conducted in China. Among 240 patients with T2DM enrolled in this trial, 195 patients adhered to a 16-week exenatide treatment and follow-up...
July 9, 2018: Peptides
George S Stergiou, Eamon Dolan, Anastasios Kollias, Neil R Poulter, Andrew Shennan, Jan A Staessen, Zhen-Yu Zhang, Michael A Weber
According to the established validation protocols, a typical validation study of a blood pressure (BP) monitor includes general population adults with normal or elevated BP. It is recognized, however, that the automated (oscillometric) BP monitors may have different accuracy or uses in some special populations compared with adults in the general population. Thus, an automated BP monitor with proven accuracy in a general population of adults may not be accurate in a special population, and therefore separate validation is needed...
July 2018: Journal of Clinical Hypertension
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"