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https://www.readbyqxmd.com/read/29157808/a-double-blind-randomized-placebo-controlled-trial-of-saffron-stigma-crocus-sativus-l-in-mothers-suffering-from-mild-to-moderate-postpartum-depression
#1
Jamshid Tabeshpour, Farzaneh Sobhani, Seyed Alireza Sadjadi, Hossein Hosseinzadeh, Seyed Ahmad Mohajeri, Omid Rajabi, Zhila Taherzadeh, Saeid Eslami
INTRODUCTION: Numerous adverse effects of antidepressants as well as the attitudes of breastfeeding mothers, who prefer to consume herbal medicine rather than chemical drugs, encouraged us to assess the effects of saffron (Crocus sativus L.) on mothers suffering from mild-to-moderate postpartum depressive disorder. METHODS: A double-blind, randomized, and placebo-controlled trial was conducted on 60 new mothers who had a maximum score of 29 on the Beck Depression Inventory-Second Edition (BDI-II)...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29147836/effects-of-saffron%C3%A2-and-its-constituents-%C3%A2-crocin-1-crocin-2-and-crocetin-on-%C3%AE-synuclein-fibrils
#2
Eiji Inoue, Yasuharu Shimizu, Ryo Masui, Tomomi Hayakawa, Tomoe Tsubonoya, Satoko Hori, Keiichi Sudoh
Saffron, the stigma of Crocus sativus Linné (Iridaceae family), has been known to inhibit aggregation of β-amyloid, a nerve tissue protein. α-Synuclein (αS) is a 140-amino acid protein found abundantly in various regions of the brain. Its abnormal aggregation and accumulation in nerve tissue are said to cause neurodegenerative diseases such as Parkinson's disease, Lewy body dementia, and multiple-system atrophy. This study (part of this study was presented at the 137th Annual Meeting of the Pharmaceutical Society of Japan) examined the effects of saffron, its constituents (crocin-1, crocin-2, crocetin, and safranal), and crocetin structural analogs (hexadecanedioic acid, norbixin, and trans, trans-muconic acid) on αS aggregation, and αS fibril dissociation...
November 17, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29136602/saffron-in-the-treatment-of-depression-anxiety-and-other-mental-disorders-current-evidence-and-potential-mechanisms-of-action
#3
REVIEW
Mojtaba Shafiee, Soheil Arekhi, Alireza Omranzadeh, Amirhossein Sahebkar
BACKGROUND: Depression and anxiety are two common mental health problems with high economic and social costs. Currently, a number of treatments are available for patients with depression and anxiety disorders such as psychotherapy, electroconvulsive therapy and antidepressant drugs. Due to safety concerns, adverse effects, limited efficacy and low tolerability associated with many antidepressant and anti-anxiety medications, identification of novel agents with less toxicity and more favorable outcome is warranted...
November 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29136374/saffron-against-components-of-metabolic-syndrome-current-status-and-prospective
#4
Mojtaba Shafiee, Nazanin Sadat Aghili Moghaddam, Mohammad Nosrati, Mahsa Tousi, Amir Avan, Mikhail Ryzhikov, Mohammad Reza Parizadeh, Hamid Fiuji, Majid Rajabian, Amirhosein Bahreyni, Majid Khazaei, Seyed Mahdi Hassanian
Saffron, the dried stigmas of Crocus sativus L., is mainly used as a food coloring and flavoring agent. This agricultural product is used in traditional medicine for the treatment of several diseases including asthma, liver disease, menstruation disorders, and, of special interest in this review, in metabolic syndrome. Saffron and its active components including crocin, crocetin and safranal are potential therapeutic candidates for attenuating MetS complications including hypertension, hyperglycemia, obesity, and dyslipidemia...
November 14, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29134501/pharmacokinetic-properties-of-saffron-and-its-active-components
#5
Azar Hosseini, Bibi Marjan Razavi, Hossein Hosseinzadeh
Saffron as a medicinal plant has many therapeutic effects. Phytochemical studies have reported that saffron is composed of at least four active ingredients which include crocin, crocetin, picrocrocin and safranal. The carotenoids of saffron are sensitive to oxygen, light, heat and enzymatic oxidization. However, regulation of these factors is required for saffron quality. Some pharmacologic effects of saffron and its active compounds include cardioprotective, neuroprotective, memory enhancer, antidepressant and anxiolytic...
November 13, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/29128090/crocus-sativus-l-aqueous-extract-reduces-atherogenesis-increases-atherosclerotic-plaque-stability-and-improves-glucose-control-in-diabetic-atherosclerotic-animals
#6
Ei Christodoulou, N P E Kadoglou, M Stasinopoulou, O A Konstandi, C Kenoutis, Z I Kakazanis, A Rizakou, N Kostomitsopoulos, G Valsami
BACKGROUND AND AIMS: We aimed to evaluate a possible atheroprotective effect of saffron aqueous extract (SFE), and its potential anti-inflammatory mechanisms, in apoE knockout (ApoE(-/-)) mice. METHODS: Fifty male, ApoE(-/-) mice, fed a high-fat diet (HFD) for 12 weeks, were randomized into 5 groups: (1) baseline group, euthanatized, without intervention, (2) three saffron groups, receiving HFD and 30,60,90 mg/kg/day of SFE, respectively, for four weeks, per os through gavage, after reconstitution in water for injection (WFI), (3) control group (COG), receiving daily HFD and the same volume of WFI (four weeks)...
November 1, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29124962/effect-of-ultrasonic-waves-on-crocin-and-safranal-content-and-expression-of-their-controlling-genes-in-suspension-culture-of-saffron-crocus-sativus%C3%A2-l
#7
Tofigh Taherkhani, Rasool Asghari Zakaria, Mansoor Omidi, Naser Zare
The expression of biosynthesis controlling genes of crocin and safranal in saffron (Crocus sativus) can be influenced by ultrasonic waves. Sterilized saffron corms were cultured in a ½-MS medium supplemented by 2-4-D and BAP.  Saffron callus cells were treated with ultrasonic waves in a cellular suspension culture under optimal growth conditions. The samples were collected at 24 and 72 hours after treatment in three replications. The secondary metabolites were measured by high-performance liquid chromatography and the gene expression was analysed by the real-time polymerase chain reaction...
November 10, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29093644/synergistic-anticancer-effect-of-combined-crocetin-and-cisplatin-on-kyse-150-cells-via-p53-p21-pathway
#8
Sheng Li, Xiu-Yin Shen, Ting Ouyang, Yuhua Qu, Tao Luo, Hua-Qiao Wang
Background: More than 400,000 patients die from esophageal cancer annually. Considerable efforts have been made to develop new and effective treatments, one of which is directed toward herbal medication. Crocetin is a natural carotenoid dicarboxylic acid isolated from the Chinese herb saffron. We recently reported on the anticancer effects of saffron. This study aimed to determine whether crocetin combined cisplatin has synergistic effect in KYSE-150 cells and explore the underlying mechanism...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/29068592/the-effects-of-crocin-on-the-symptoms-of-depression-in-subjects-with-metabolic-syndrome
#9
Irandokht Nikbakht Jam, Amir Hossein Sahebkar, Saeid Eslami, Naghmeh Mokhber, Mina Nosrati, Mohammad Khademi, Mojtaba Foroutan-Tanha, Majid Ghayour-Mobarhan, Farzin Hadizadeh, Gordon Ferns, Masoumeh Abbasi
BACKGROUND: Studies have suggested that metabolic syndrome (MetS) is associated with increased depressive symptoms, and reducing depression in subjects with MetS is important. Crocin, an active component of saffron, has useful properties for subjects with MetS, including antidepressant properties. OBJECTIVES: The aim of the study was to assess the effect of a preparation of crocin on the symptoms of depression in subjects with MetS, and the relationship between changes in those symptoms and the serum pro-oxidant/anti-oxidant balance (PAB)...
September 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29062366/comparison-of-saffron-and-fluvoxamine-in-the-treatment-of-mild-to-moderate-obsessive-compulsive-disorder-a-double-blind-randomized-clinical-trial
#10
Sophia Esalatmanesh, Mojtaba Biuseh, Ahmad Ali Noorbala, Seyed-Ali Mostafavi, Farzin Rezaei, Bita Mesgarpour, Payam Mohammadinejad, Shahin Akhondzadeh
Objective: There are different pathophysiological mechanisms for obsessive- compulsive disorder (OCD) as suggested by the serotonergic, dopaminergic, and glutamatergic hypotheses. The present study aimed at comparing the efficacy and safety of saffron (stigma of Crocus sativus) and fluvoxamine in the treatment of mild to moderate obsessive- compulsive disorder. Method: In this study, 50 males and females, aged 18 to 60 years, with mild to moderate OCD, participated. The patients were randomly assigned to receive either saffron (30 mg/day, 15 mg twice a day) or fluvoxamine (100 mg/day) for 10 weeks...
July 2017: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/29027276/natural-medicines-for-acute-renal-failure-a-review
#11
REVIEW
Motahareh Boozari, Hossein Hosseinzadeh
Acute renal failure (ARF) is a life-threating disease with high mortality percentage. Two important mechanisms of ARF are inflammation and oxidative stress. Plants are rich source of antioxidant compounds and have a strong anti-inflammatory activity, so they may be useful for the treatment of ARF. Some herbal medicines are effective against different models of experimentally induced ARF such as cisplatin, gentamicin, glycerol, and ischemia-reperfusion injury. Some of these plants such as ginseng, black seed, ginger, garlic, grape, pomegranate, saffron, and green tea are so famous and are effective against various models of ARF...
October 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29024138/safranal-inhibits-hela-cell-viability-by-perturbing-the-reassembly-potential-of-microtubules
#12
Sanith Cheriyamundath, Sinjan Choudhary, Manu Lopus
Saffron, a spice from Crocus sativus, has been known for its health benefits and medicinal properties. Safranal is a component of saffron and is known for its antioxidant and anticancer properties. In this study, we elucidated a possible tubulin-targeted antiproliferative mechanism of action of safranal. In vitro, the compound perturbed secondary structure of tubulin without altering net microtubule polymer mass. It inhibited HeLa cell viability in a concentration-dependent manner, with minimal damage to cellular microtubules...
October 11, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29016414/prenatal-diagnosis-of-a-melanotic-neuroectodermal-tumor-of-infancy-mnti-a-case-report-with-a-favorable-outcome-after-chemotherapy-failure-and-incomplete-resection
#13
Audrey Moreau, Louise Galmiche, Kahina Belhous, Gerald Franchi, Vincent Couloigner, Jerome Nevoux, Pierre Antoine Aymard, Arnaud Picard, Veronique Minard-Colin, Natacha Kadlub
We present the case of a woman referred to our department at 34 weeks of pregnancy with a fetal ultrasonographic scan showing a mass that had developed within the right maxilla with invasion of the orbit. A retrospective examination showed that this tumor had been present since the 12th week of pregnancy. At 39+4 weeks of gestation, a boy was born. He presented a black firm aspect in the maxilla. A computed tomographic scan and magnetic resonance imaging revealed a soft tissue swelling over the right maxilla, extending into the orbit but without invasion of the globe...
October 9, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28984113/neuroprotective-effect-of-safranal-an-active-ingredient-of-crocus-sativus-in-a-rat-model-of-transient-cerebral-ischemia
#14
Hamid R Sadeghnia, Hamideh Shaterzadeh, Fatemeh Forouzanfar, Hossein Hosseinzadeh
Safranal is a monoterpene aldehyde found in saffron (Crocus sativus L.) petals. It has been previously reported that safranal has a wide range of activities such as antioxidant and anti-inflammatory effects. In this study, we examined the effect of safranal on brain injuries in a transient model of focal cerebral ischemia. Transient focal cerebral ischemia was induced by middle cerebral artery occlusion for 30 min, followed by 24 h of reperfusion. Safranal in the doses of 72.5 and 145 mg/kg was administered intraperitoneally at 0, 3, and 6 h after reperfusion...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28981773/evolutionarily-distinct-carotenoid-cleavage-dioxygenases-are-responsible-for-crocetin-production-in-buddleja-davidii
#15
Oussama Ahrazem, Gianfranco Diretto, Javier Argandoña, Ángela Rubio-Moraga, José Manuel Julve, Diego Orzáez, Antonio Granell, Lourdes Gómez-Gómez, Qiao Zhao
Crocetin, one of the few colored apocarotenoids known in nature, is present in flowers and fruits and has long been used medicinally and as a colorant. Saffron is the main source of crocetin, although a few other plants produce lower amounts of this apocarotenoid. Notably, Buddleja davidii accumulates crocetin in its flowers. Recently, a carotenoid dioxygenase cleavage enzyme, CCD2, has been characterized as responsible for crocetin production in Crocus species. We searched for CCD2 homologues in B. davidii and identified several CCD enzymes from the CCD1 and CCD4 subfamilies...
July 20, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28964663/saffron-crocus-sativus-intake-provides-nutritional-preconditioning-against-myocardial-ischemia-reperfusion-injury-in-wild-type-and-apoe-mice-involvement-of-nrf2-activation
#16
P Efentakis, A Rizakou, E Christodoulou, A Chatzianastasiou, M G López, R León, E Balafas, N P E Kadoglou, I Tseti, H Skaltsa, N Kostomitsopoulos, E K Iliodromitis, G Valsami, I Andreadou
BACKGROUND AND AIMS: Saffron is an antioxidant herbal derivative; however, its efficacy as a nutritional cardioprotective agent has not been fully elucidated. We investigated the cardioprotective properties of a standardized saffron aqueous extract (SFE) against ischemia/reperfusion (I/R) injury in Wild-Type (WT) and ApoE((-/-)) mice and the underlying molecular mechanisms. METHODS AND RESULTS: WT and ApoE((-/-)) mice were subjected to 30 min I and 2 h R, with the following per os interventions for 4 weeks: 1) WT Control Group, receiving Water for Injection (WFI); 2) WT Crocus Group, receiving SFE at a dose of 60 mg/kg/day; 3) WT Crocus + Wort group, receiving SFE as described above and wortmannin at a dose of 60 μg/kg bolus 15 min before R; 4) ApoE((-/-)) Control Group, receiving WFI; 5) ApoE((-/-)) Crocus Group, receiving SFE at a dose of 60 mg/kg/day and 6) ApoE((-/-)) Crocus + Wort: receiving SFE as described above and wortmannin at a dose of 60 μg/kg bolus, 15 min before R...
October 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28952241/-research-progress-on-quality-evaluation-of-saffron
#17
REVIEW
Jiang-di Liu, Zhen Ouyang, Bin Yang
Saffron, a precious spice and a traditional medicinal herb in the international trade market, has attracted much attention about its quality evaluation.Saffron has been successfully cultivated in some areas in China,such as Shanghai, Zhejiang, Jiangsu, but few studies were focused on the quality difference between saffron cultivated in China and in foreign countries, which obstructed the entrance of saffron cultivated in China into international trade market. The paper is to review the current research progress on quality evaluation of saffron from the following respects: the chemical composition, the identification of authenticity and adulterants, the detection of artificial colorants, the indexes and methods of quality evaluation,the quality evaluation of different specifications in the international trade market, and the parameters which affected the quality of saffron...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28941412/rapid-determination-of-crocins-in-saffron-by-near-infrared-spectroscopy-combined-with-chemometric-techniques
#18
REVIEW
Shuailing Li, Qingsong Shao, Zhonghua Lu, Chengli Duan, Haojun Yi, Liyang Su
Saffron is an expensive spice. Its primary effective constituents are crocin I and II, and the contents of these compounds directly affect the quality and commercial value of saffron. In this study, near-infrared spectroscopy was combined with chemometric techniques for the determination of crocin I and II in saffron. Partial least squares regression models were built for the quantification of crocin I and II. By comparing different spectral ranges and spectral pretreatment methods (no pretreatment, vector normalization, subtract a straight line, multiplicative scatter correction, minimum-maximum normalization, eliminate the constant offset, first derivative, and second derivative), optimum models were developed...
September 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28937827/effect-of-saffron-on-metabolic-profile-and-retina-in-apolipoprotein-e-knockout-mice-fed-a-high-fat-diet
#19
Evangelos K Doumouchtsis, Aspasia Tzani, Ilias P Doulamis, Panagiotis Konstantopoulos, Korou Laskarina-Maria, Georgios Agrogiannis, Emmanouil Agapitos, Marilita M Moschos, Alkiviadis Kostakis, Despina N Perrea
Saffron is a spice that has been traditionally used as a regimen for a variety of diseases due to its potent antioxidant attributes. It is well documented that impaired systemic oxidative status is firmly associated with diverse adverse effects including retinal damage. The aim of this study was to investigate the role of saffron administration against the retinal damage in apoE -/- mice fed a high-fat diet, since they constitute a designated experimental model susceptible to oxidative stress. Twenty-one mice were allocated into three groups: Group A (control, n = 7 c57bl/6 mice) received standard chow diet; Group B (high-fat, n = 7 apoE -/- mice) received a high-fat diet; and Group C (high-fat and saffron, n = 7 apoE -/- mice) received a high-fat diet and saffron (25 mg/kg/d) through their drinking water...
September 22, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28932183/plant-polyphenols-and-exendin-4-prevent-hyperactivity-and-tnf-%C3%AE-release-in-lps-treated-in-vitro-neuron-astrocyte-microglial-networks
#20
Francesca Gullo, Michela Ceriani, Alessia D'Aloia, Enzo Wanke, Andrew Constanti, Barbara Costa, Marzia Lecchi
Increasing evidence supports a decisive role for neuroinflammation in the neurodegenerative process of several central nervous system (CNS) disorders. Microglia are essential mediators of neuroinflammation and can regulate a broad spectrum of cellular responses by releasing reactive oxygen intermediates, nitric oxide, proteases, excitatory amino acids, and cytokines. We have recently shown that also in ex-vivo cortical networks of neurons, astrocytes and microglia, an increased level of tumor necrosis factor-alpha (TNF-α) was detected a few hours after exposure to the bacterial endotoxin lipopolysaccharide (LPS)...
2017: Frontiers in Neuroscience
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