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Adrian L Lopresti, Peter D Drummond
BACKGROUND: Several studies have supported the antidepressant effects of curcumin (from the spice turmeric) and saffron for people with major depressive disorder. However, these studies have been hampered by poor designs, small sample sizes, short treatment duration, and similar intervention dosages. Furthermore, the antidepressant effects of combined curcumin and saffron administration are unknown. METHODS: In a randomised, double-blind, placebo-controlled study, 123 individuals with major depressive disorder were allocated to one of four treatment conditions, comprising placebo, low-dose curcumin extract (250mg b...
October 1, 2016: Journal of Affective Disorders
A Ghajar, S M Neishabouri, N Velayati, L Jahangard, N Matinnia, M Haghighi, A Ghaleiha, M Afarideh, S Salimi, A Meysamie, S Akhondzadeh
Introduction: Saffron (Crocus sativus L.) has demonstrated antidepressant effects in clinical studies and extensive anxiolytic effects in experimental animal models. Methods: 66 patients with major depressive disorder accompanied by anxious distress were randomly assigned to receive either saffron (30 mg/day) or citalopram (40 mg/day) for 6 weeks. Hamilton Rating Scale for Depression (HAM-D) and Hamilton Rating Scale for Anxiety (HAM-A) were used to assess treatment effect during the trial. Results: 60 participants finished the study...
October 4, 2016: Pharmacopsychiatry
Nicholas V Skladnev, Varshika Ganeshan, Ji Yeon Kim, Thomas Burton, John Mitrofanis, Jonathan Stone, Daniel M Johnstone
Dietary saffron has shown promise as a neuroprotective intervention in clinical trials of retinal degeneration and dementia and in animal models of multiple CNS disorders, including Parkinson's disease. This therapeutic potential makes it important to define the relationship between dose and protection and the mechanisms involved. To explore these two issues, mice were pre-conditioned by providing an aqueous extract of saffron (0.01% w/v) as their drinking water for two, five or ten days before administration of the parkinsonian neurotoxin MPTP (50mg/kg)...
October 1, 2016: Journal of Neurochemistry
Fariheen Aisha Ansari, Shaikh Nisar Ali, Riaz Mahmood
Sodium nitrite (NaNO2 ) is a common contaminant of drinking water and food and feed chain. Nitrite induces oxidative damage in humans and animals. In this work we studied the protective effect of crocin, the active constituent of Crocus sativus (saffron), on NaNO2 -induced oxidative damage in human erythrocytes. Changes in oxidative stress parameters following NaNO2 incubation of erythrocytes in presence and absence of crocin were determined. It was found that crocin pre-treatment significantly attenuated NaNO2 -induced oxidative damage of proteins, lipids and plasma membrane...
September 28, 2016: Cell Biology International
Josep Rubert, Ondrej Lacina, Milena Zachariasova, Jana Hajslova
No abstract text is available yet for this article.
February 15, 2017: Food Chemistry
Eleftherios A Petrakis, Laura R Cagliani, Petros A Tarantilis, Moschos G Polissiou, Roberto Consonni
Saffron, the dried red stigmas of Crocus sativus L., is considered as one of the most expensive spices worldwide, and as such, it is prone to adulteration. This study introduces an NMR-based approach to identify and determine the adulteration of saffron with Sudan I-IV dyes. A complete (1)H and (13)C resonance assignment for Sudan I-IV, achieved by two-dimensional homonuclear and heteronuclear NMR experiments, is reported for the first time. Specific different proton signals for the identification of each Sudan dye in adulterated saffron can be utilised for quantitative (1)H NMR (qHNMR), a well-established method for quantitative analysis...
February 15, 2017: Food Chemistry
Shinji Soeda, Kosuke Aritake, Yoshihiro Urade, Hiroshi Sato, Yukihiro Shoyama
We first considered that saffron is really safety food because it has a long-use history. The neuroprotective activities of saffron and its major constituent, crocin, are separately discussed in vitro and in vivo. We reviewed the inhibitory activities of crocin against PC-12 cell apoptosis. The oxidative stress decreased the cellular levels of glutathione (GSH) which is an inhibitor of neutral sphingomyelinase (N-SMase). Therefore, the level of GSH was assayed by the addition of crocin resulted in the activation of glutathione reductase (GR)...
2016: Advances in Neurobiology
Mahendra Shukla, Swati Jaiswal, Abhisheak Sharma, Pradeep Kumar Srivastava, Abhishek Arya, Anil Kumar Dwivedi, Jawahar Lal
OBJECTIVE: Curcumin, the golden spice from Indian saffron, has shown chemoprotective action against many types of cancer including breast cancer. However, poor oral bioavailability is the major hurdle in its clinical application. In the recent years, self-nanoemulsifying drug delivery system (SNEDDS) has emerged as a promising tool to improve the oral absorption and enhancing the bioavailability of poorly water-soluble drugs. In this context, complexation with lipid carriers like phospholipid has also shown the tremendous potential to improve the solubility and therapeutic efficacy of certain drugs with poor oral bioavailability...
October 6, 2016: Drug Development and Industrial Pharmacy
Saffron Brown
New nursing students are about to enter a unique profession.
August 24, 2016: Nursing Standard
Hossein Ali Safakhah, Tahereh Taghavi, Ali Rashidy-Pour, Abbas Ali Vafaei, Mina Sokhanvar, Narges Mohebbi, Mostafa Rezaei-Tavirani
This study was designed to investigate the therapeutic effects of saffron (Crocus sativus L.) and its main constituent crocin on neuropathic pain behavioral responses induced by chronic constriction injury (CCI) in rats. Adult male Wistar rats (200 to 250 g) were randomly assigned into 5 groups: Sham + saline, CCI + saline, CCI+ saffron (30 mg/kg), CCI + crocin (15 mg/kg) and CCI + crocin (30 mg/kg). CCI was induced by applying 4 loose ligatures around the sciatic nerve. Two weeks after nerve lesion, injections of saline, saffron or crocin were started and continued until 26(th) day post-surgery...
2016: Iranian Journal of Pharmaceutical Research: IJPR
Nils-Otto Ahnfelt, Hjalmar Fors
Historians of science and medicine have rarely applied themselves to reproducing the experiments and practices of medicine and pharmacy. This paper delineates our efforts to reproduce "Swedish Bitters," an early modern composite medicine in wide European use from the 1730s to the present. In its original formulation, it was made from seven medicinal simples: aloe, rhubarb, saffron, myrrh, gentian, zedoary and agarikon. These were mixed in alcohol together with some theriac, a composite medicine of classical origin...
May 2016: Ambix
L Kashani, S Eslatmanesh, N Saedi, N Niroomand, M Ebrahimi, M Hosseinian, T Foroughifar, S Salimi, S Akhondzadeh
Introduction: Postpartum depression is a common mental health problem that is associated with maternal suffering. The aim of this double-blind clinical trial was to compare safety and efficacy of saffron and fluoxetine in treatment of mild to moderate postpartum depression. Methods: This was a 6-week, double-blind, randomized clinical trial. Subjects were women aged 18-45 years with mild to moderate postpartum depression who had Hamilton Depression Rating Scale (HDRS 17-item) score≤18. Eligible participants were randomized to receive either a capsule of saffron (15 mg capsule) or fluoxetine (20 mg capsule) twice daily for 6 weeks...
September 5, 2016: Pharmacopsychiatry
Ayşegül Aksoy Gökmen, Selmin Çaylak, Burak Ekrem Citil, Hamdi Sözen, Cem Şahin, Erkan Yula, Selçuk Kaya, Mustafa Demirci
OBJECTIVE: This study aimed to determine the incidence of Strongyloides stercoralis in individuals who live in rural areas in the towns near Mugla and have contact with humid soil and gather saffron milk cap mushroom in autumn, and to obtain epidemiological data in our region. METHODS: A total of 281 volunteers were included; 192 of them were the individuals who only gather mushroom, only work in the garden, or gather mushroom as well as work in the garden, while 89 had no contact with the soil...
June 2016: Türkiye Parazitolojii Dergisi
V Sapanidou, I Taitzoglou, I Tsakmakidis, I Kourtzelis, D Fletouris, A Theodoridis, S Lavrentiadou, M Tsantarliotou
Oxidative stress is one of the major factors that contribute to poor semen quality and low rates of in vitro fertilization. Crocetin, a main constituent of saffron (Crocus sativus L.) possesses potent antioxidant activity, by scavenging reactive oxygen species (ROS) and/or enhancing the activity of intracellular antioxidant enzymes. The aim of this study was to investigate, for the first time, the effect of crocetin on the quality characteristics of bull spermatozoa and fertilization rate. For this reason, frozen/thawed bovine spermatozoa were incubated with crocetin (1, 2...
August 30, 2016: Andrology
E Altinoz, T Ozmen, Z Oner, H Elbe, M E Erdemli, H G Bag
The aim of the current study was to investigate the outcomes in a rat model of an acute swimming exercise induced oxidative stress in brain, kidney, liver, skeletal and cardiac muscles using supplementation with crocin. Rats were divided into the eight groups; Normal Control (NC: Untreated and did not swim), Crocin Control (CC: Received crocin and did not swim), Exercise-1 (E-1: Untreated and swam), Exercise-24 (E-24: Untreated and swam), Exercise-48 (E-48: Untreated and swam), Exercise+Crocin-1 (EC-1: Received crocin and swam), Exercise+Crocin-24 (EC-24: Received crocin and swam), Exercise+Crocin-48 (EC-48: Received crocin and swam)...
2016: Bratislavské Lekárske Listy
Isak S Pretorius
Over the past 15 years, the seismic shifts caused by the convergence of biomolecular, chemical, physical, mathematical, and computational sciences alongside cutting-edge developments in information technology and engineering have erupted into a new field of scientific endeavor dubbed Synthetic Biology. Recent rapid advances in high-throughput DNA sequencing and DNA synthesis techniques are enabling the design and construction of new biological parts (genes), devices (gene networks) and modules (biosynthetic pathways), and the redesign of biological systems (cells and organisms) for useful purposes...
August 18, 2016: Critical Reviews in Biotechnology
Saeed Samarghandian, Mohsen Azimi-Nezhad, Tahereh Farkhondeh
OBJECTIVE: Crocin, a bioactive component of saffron, has many biological effects such as antioxidant property. The present study investigated the anti-hyperglycemic, anti oxidant and immunomodulatory effects of crocin on streptozotocin-induced diabetic rats. METHOD: In this study, the rats were divided into the following groups of 9 animals each: control, untreated diabetic, three crocin (10, 20, 30mg/kg/day)-treated diabetic groups. Diabetes was induced by streptozotocin in rats...
December 2016: Cytokine
Jie Zheng, Yue Zhou, Ya Li, Dong-Ping Xu, Sha Li, Hua-Bin Li
Spices have been widely used as food flavorings and folk medicines for thousands of years. Numerous studies have documented the antioxidant, anti-inflammatory and immunomodulatory effects of spices, which might be related to prevention and treatment of several cancers, including lung, liver, breast, stomach, colorectum, cervix, and prostate cancers. Several spices are potential sources for prevention and treatment of cancers, such as Curcuma longa (tumeric), Nigella sativa (black cumin), Zingiber officinale (ginger), Allium sativum (garlic), Crocus sativus (saffron), Piper nigrum (black pepper) and Capsicum annum (chili pepper), which contained several important bioactive compounds, such as curcumin, thymoquinone, piperine and capsaicin...
2016: Nutrients
Mina Taati, Esmaeal Tamaddonfard, Amir Erfanparast, Hamid Ghasemi
OBJECTIVE: Crocin and safranal, as the major constituents of saffron, have many biological activities. This study investigated the effects of crocin and safranal on yawning response induced by intracerebroventricular (i.c.v.) injection of histamine in rats. MATERIALS AND METHODS: In ketamine/xylazine-anesthetized rats, a guide cannula was implanted in the right ventricle of the brain and yawning induced by i.c.v. injection of histamine. Crocin and safranal were intraperitoneally (i...
July 2016: Avicenna Journal of Phytomedicine
Ali Forouzanfar, Majid Reza Mokhtari, Mohammad Kamalinezhad, Mohammad Babayian, Mandana Tavakoli-Kakhki, Mohammad Hasan Lotfalizadeh
BACKGROUND: Gingivitis is an inflammatory disease involving the gums. Saffron contains various forms of flavonoids, glycosides, and anthocyanin compounds that are proven to have anti-inflammatory and antioxidant effects. This study evaluates the anti-inflammatory effects of Saffron stigma on gingival indices in patients with marginal generalized plaque-induced gingivitis. METHODS: For this study, we used toothpaste containing aqueous extract of Saffron stigma. Twenty-two patients with generalized marginal gingivitis were selected...
May 2016: Iranian Journal of Medical Sciences
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