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https://www.readbyqxmd.com/read/28427103/saffron-flower-extract-promotes-scratch-wound-closure-of-keratinocytes-and-enhances-vegf-production
#1
Sheela Verjee, Eliane Garo, Sarah Pelaez, Orlando Fertig, Matthias Hamburger, Veronika Butterweck
During saffron (Crocus sativus) spice production, large amounts of floral biowaste are generated. It was the aim of this study to develop a value-added product from saffron floral biowaste to be used as a natural cosmetic ingredient. HPLC-PDA-MS analysis of saffron flower extracts revealed the presence of flavonols with the highest amounts in the acetone extract. Kaempferol-3-O-sophoroside was identified as the main flavonoid in the acetone extract (saffron flower acetone extract). Saffron flower acetone extract and kaempferol-3-O-sophoroside were tested in HaCaT cells for potential effects on cell migration, proliferation, and for anti-inflammatory properties...
April 20, 2017: Planta Medica
https://www.readbyqxmd.com/read/28407293/anti-tumor-effects-of-crocetin-and-related-molecular-targets
#2
REVIEW
Maliheh Moradzadeh, Hamid Reza Sadeghnia, Alijan Tabarraei, Amirhossein Sahebkar
Natural products have gained a wide popularity as chemopreventive and anti-cancer agents owing to their multi-mechanistic mode of action, availability and synergism with several conventional chemotherapeutic agents. Crocetin is a carotenoid compound isolated from the stigma of Crocus sativus L. (saffron). Crocetin has shown promising effects as an anti-tumor agent in animal models and cell culture systems. Crocetin retards the growth of cancer cells via inhibiting nucleic acid synthesis, enhancing anti-oxidative system, and inducing apoptosis and differentiation pathways...
April 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28400798/neuroprotective-properties-of-dietary-saffron-more-than-just-a-chemical-scavenger
#3
Nicholas V Skladnev, Daniel M Johnstone
No abstract text is available yet for this article.
February 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28392907/protective-effect-of-crocus-sativus-l-saffron-extract-on-spinal-cord-ischemia-reperfusion-injury-in-rats
#4
Gholam Hossein Farjah, Shadi Salehi, Mohammad Hasan Ansari, Bagher Pourheidar
OBJECTIVES: Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. MATERIALS AND METHODS: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. RESULTS: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (P<0...
March 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28385604/the-niche-and-phylogeography-of-a-passerine-reveal-the-history-of-biological-diversification-between-the-andean-and-the-atlantic-forests
#5
Natalia Trujillo-Arias, Gisele Dantas, Enrique Arbeláez-Cortés, Kazuya Naoki, Maria I Gómez, Fabricio R Santos, Cristina Y Miyaki, Alexandre Aleixo, Pablo L Tubaro, Gustavo S Cabanne
The Atlantic Forest is separated from the Andean tropical forest by dry and open vegetation biomes (Chaco and Cerrado). Despite this isolation, both rainforests share closely related lineages, which suggest a past connection. This connection could have been important for forest taxa evolution. In this study, we used the Saffron-billed Sparrow (Arremon flavirostris) as a model to evaluate whether the Andean and the Atlantic forests act as a refugia system, as well as to test for a history of biogeographic connection between them...
April 3, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/28372231/novel-quantitative-real-time-pcr-approach-to-determine-safflower-carthamus-tinctorius-adulteration-in-saffron-crocus-sativus
#6
Caterina Villa, Joana Costa, M Beatriz P P Oliveira, Isabel Mafra
This work intended to develop DNA-based methods to detect and quantify safflower as an adulterant in saffron. Species-specific PCR and real-time PCR with EvaGreen dye targeting the ITS region of Carthamus tinctorius L. (safflower) were successfully proposed. The assays allowed absolute and relative sensitivities of 2pg of safflower DNA (∼1.4 DNA copies) and 0.1% of safflower in saffron (Crocus sativus L.), respectively. A normalised real-time PCR approach was also proposed in the range of 0.1-20% (w/w) of safflower in saffron, which was successfully validated and applied to commercial saffron samples (stigmas, powders and seasonings)...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28369196/functional-genomics-of-apocarotenoids-in-saffron-insights-from-chemistry-molecular-biology-and-therapeutic-applications
#7
Manoj K Dhar, Munish Sharma, Archana Bhat, Nikhil K Chrungoo, Sanjana Kaul
Saffron is considered to be the costliest spice of the world. It has been regarded as highly valued medicinal plant in Ayurveda to treat various ailments. Over the past few years, considerable interest has developed in saffron because of its anticancer, antimutagenic, antioxidant and immunomodulatory properties. Saffron's colour, bitter taste and aroma are its three main and peculiar characteristics, which are conferred by three chemicals namely: crocin, picrocrocin and safranal, respectively. The present review focuses on recent research/progress made in saffron in the area of functional genomics and highlights the potential of several genes and transcription factors involved in carotenoid/apocarotenoid pathway and responsible for flavour and aroma of saffron...
March 28, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/28367420/comparative-study-on-the-preventive-effect-of-saffron-carotenoids-crocin-and-crocetin-in-nmu-induced-breast-cancer-in-rats
#8
Meysam Sajjadi, Zahra Bathaie
OBJECTIVE: Crocin (Cro) and crocetin (Crt) are two widely known saffron carotenoids, which exert anticancer effects by different mechanisms. Here, we investigated and compared the preventive effect of Cro and Crt at the initiation and promotion stages of breast cancer induction in an animal model. MATERIALS AND METHODS: In this experimental study, female Wistar albino rats were injected with three doses of N-methyl-N-nitrosourea (NMU). The preventive intervention was done at different times for the initiation and promotion stages...
April 2017: Cell Journal
https://www.readbyqxmd.com/read/28351329/crocetin-shifts-autophagic-cell-survival-to-death-of-breast-cancer-cells-in-chemotherapy
#9
Ailian Zhang, Jincheng Li
The chemotherapy with fluorouracil is not always effective, in which some breast cancer cells may survive the fluorouracil treatment through enhanced autophagy. Crocetin is the major constituent of saffron, a Chinese traditional herb, which has recently found to have multiple pharmacological effects, including anticancer. However, the effects of Crocetin on the outcome of fluorouracil therapy for breast cancer have not been studied. Here, we showed that fluorouracil treatment inhibited the growth of breast cancer cells, in either a Cell Counting Kit-8 assay or an MTT assay...
March 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28337976/antiproliferative-activity-of-crocin-involves-targeting-of-microtubules-in-breast-cancer-cells
#10
Rupali R Hire, Shalini Srivastava, Melissa B Davis, Ananda Kumar Konreddy, Dulal Panda
Crocin, a component of saffron spice, is known to have an anticancer activity. However, the targets of crocin are not known. In this study, crocin was found to inhibit the proliferation of HCC70, HCC1806, HeLa and CCD1059sk cells by targeting microtubules. Crocin depolymerized both the interphase and mitotic microtubules of different cancer cells, inhibited mitosis and induced multipolar spindle formation in these cells. In vitro, crocin inhibited the assembly of pure tubulin as well as the assembly of microtubule-associated protein rich tubulin...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28317741/a-novel-method-for-the-quality-control-of-saffron-through-the-simultaneous-analysis-of-authenticity-and-adulteration-markers-by-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#11
Miguel Guijarro-Díez, María Castro-Puyana, Antonio Luis Crego, María Luisa Marina
A liquid chromatography-(quadrupole-time of flight)-mass spectrometry methodology was developed to assess the authenticity of saffron through the analysis of a group of kaempferol derivatives recently proposed as novel authenticity markers as a result of a metabolomic study of saffron (kaempferol 3-O-glucoside, kaempferol 3-O-sophoroside, kaempferol 3,7-O-diglucoside, kaempferol 3,7,4'-O-triglucoside, kaempferol 3-O-sophoroside-7-O-glucoside). Geniposide was also studied as an adulteration marker of saffron with gardenia...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28298158/intake-of-saffron-reduces-%C3%AE-radiation-induced-genotoxicity-and-oxidative-stress-in-mice
#12
Apurva Koul, Suresh K Abraham
Saffron (SAF), the dried stigmas of Crocus sativus is commonly used for flavouring and coloring food. Studies on bioactivity of SAF have demonstrated its in vivo antioxidant activity. The aim of our study was to assess the impact of SAF intake on γ-radiation (RAD) induced: (a) chromosomal damage, (b) oxidative stress in liver and brain and (c) histopathological effects in the intestinal cells and male germ cells in mice. Freeze-dried aqueous extract of SAF was used for the experiments. Our preliminary cell-free DNA nicking assay using pBR322 DNA revealed protective effects of freeze-dried SAF extract against hydroxyl radical induced DNA damage...
March 15, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28295507/crocin-suppresses-constitutively-active-stat3-through-induction-of-protein-tyrosine-phosphatase-shp-1
#13
Buyun Kim, Ki Yong Lee, Byoungduck Park
The aim of the present study is to investigate the effect of a natural compound crocin, one of the active components of saffron, on human multiple myeloma cells. Crocin effectively suppressed constitutive STAT3 activation, translocation of STAT3 to the nucleus, and its target gene expression. The suppression of STAT3 was mediated through the inhibition of activation of protein tyrosine kinases JAK1, JAK2 and c-Src. We found that crocin induced the expression of SHP-1, a tyrosine protein phosphatase, and pervanadate treatment reversed the crocin-induced downregulation of STAT3, suggesting the involvement of a protein tyrosine phosphatase...
March 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28293386/toxicology-effects-of-saffron-and-its-constituents-a-review
#14
REVIEW
Hasan Badie Bostan, Soghra Mehri, Hossein Hosseinzadeh
Saffron (Crocus sativus L.) has been considered as a medicinal plant since ancient times and also widely used as food additive for its color, taste and odor. The pharmacological properties of saffron and its main constituents, crocin and safranal have been evaluated using different in vivo and in vitro models. Additionally, other lines of studies have found toxicological effects of saffron. However, a comprehensive review that covers all aspects of its toxicity has not been published yet. The current study provides classified information about the toxic effects of saffron and its constituents in various exposure conditions including acute, sub-acute, sub-chronic and chronic studies...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28278645/short-communication-investigating-the-effect-of-saffron-crocus-sativus-l-nano-sizing-on-its-colour-extraction-efficiency-a-preliminary-study
#15
Mehrdad Abootalebian, Maryam Karbasi, Maliheh Sadeghi, Mahnaz Abdinian, Igor Polikarpov
This study investigated the effect of saffron nano-sizing on its the colour extraction yield. The whole stigma was ball-milled at three different times (10, 20 and 100 h), immediately or with a 24 h delay was submitted to absorption test, and then the colour extraction efficiency was determined. When stigma was milled for 100 h, its particle size was reduced to less than 20 nm, as shown by SEM and TEM images, and its extraction efficiency was considerably increased by 19.8% as compared with the stigma blended for 10 min...
February 24, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28261627/in-silico-identification-of-mirnas-and-their-target-genes-and-analysis-of-gene-co-expression-network-in-saffron-crocus-sativus-l-stigma
#16
Zahra Zinati, Roohollah Shamloo-Dashtpagerdi, Ali Behpouri
As an aromatic and colorful plant of substantive taste, saffron (Crocus sativus L.) owes such properties of matter to growing class of the secondary metabolites derived from the carotenoids, apocarotenoids. Regarding the critical role of microRNAs in secondary metabolic synthesis and the limited number of identified miRNAs in C. sativus, on the other hand, one may see the point how the characterization of miRNAs along with the corresponding target genes in C. sativus might expand our perspectives on the roles of miRNAs in carotenoid/apocarotenoid biosynthetic pathway...
December 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/28254570/nanoparticles-based-on-crocin-loaded-chitosan-alginate-biopolymers-antioxidant-activities-bioavailability-and-anticancer-properties
#17
Somayeh Rahaiee, Maryam Hashemi, Seyed Abbas Shojaosadati, Sohrab Moini, Seyed Hadi Razavi
Crocin, a water-soluble carotenoid in saffron, is a highly bioactive compound with limited use due to instability to pH variations, heat and oxidative stress, rapid absorption and low bioavailability. In this study, chitosan-alginate nanoparticles, considered as a new vehicle for crocin to improve properties in terms of antioxidant activity, bioavailability and anticancer activity. The swelling of crocin loaded nanoparticles was pH-dependent so that the highest swelling ratio (16g/g) was observed in acidic condition (pH=1...
June 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28250905/possible-role-of-common-spices-as-a-preventive-and-therapeutic-agent-for-alzheimer-s-disease
#18
REVIEW
Omid Mirmosayyeb, Amirpouya Tanhaei, Hamid R Sohrabi, Ralph N Martins, Mana Tanhaei, Mohammad Amin Najafi, Ali Safaei, Rokhsareh Meamar
For centuries, spices have been consumed as food additives or medicinal agents. However, there is increasing evidence indicating the plant-based foods in regular diet may lower the risk of neurodegenerative diseases including Alzheimer disease. Spices, as one of the most commonly used plant-based food additives may provide more than just flavors, but as agents that may prevent or even halt neurodegenerative processes associated with aging. In this article, we review the role and application of five commonly used dietary spices including saffron turmeric, pepper family, zingiber, and cinnamon...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28238066/crocin-inhibits-oxidative-stress-and-pro-inflammatory-response-of-microglial-cells-associated-with-diabetic-retinopathy-through-the-activation-of-pi3k-akt-signaling-pathway
#19
Xinguang Yang, Fuquan Huo, Bei Liu, Jing Liu, Tao Chen, Junping Li, Zhongqiao Zhu, Bochang Lv
Diabetic retinopathy (DR) is a serious microvascular complication of diabetes mellitus that is closely associated with the degeneration and loss of retinal ganglion cells (RGCs) caused by diabetic microangiopathy and subsequent oxidative stress and an inflammatory response. Microglial cells are classed as neurogliocytes and play a significant role in neurodegenerative diseases. Over-activated microglial cells may cause neurotoxicity and induce the death and apoptosis of RGCs. Crocin is one of the two most pharmacologically bioactive constituents in saffron...
February 25, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28236605/clinical-use-of-curcumin-in-depression-a-meta-analysis
#20
Qin Xiang Ng, Shawn Shao Hong Koh, Hwei Wuen Chan, Collin Yih Xian Ho
INTRODUCTION: There is growing interest in the use of curcumin, a plant polyphenol with potent anti-inflammatory, anti-oxidant, and neuroprotective properties, as a novel antidepressant. Clinical trials have yielded conflicting conclusions pertaining to its effectiveness in depression. A meta-analysis of the topic, which has not been done until now, is therefore necessary to summarize current evidence and generate hypotheses for further research. METHODS: Using the keywords [curcumin OR diferuloylmethane OR curcuminoid OR turmeric OR Indian saffron] AND [depression OR MDD OR suicide], a preliminary search on the PubMed, Ovid, Clinical Trials Register of the Cochrane Collaboration Depression, Anxiety and Neurosis Group (CCDANTR), and Cochrane Field for Complementary Medicine database yielded 2081 articles published in English between January 1, 1960, and August 1, 2016...
February 21, 2017: Journal of the American Medical Directors Association
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