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https://www.readbyqxmd.com/read/28180016/effect-of-saffron-fan-hong-hua-on-the-readiness-of-the-uterine-cervix-in-term-pregnancy-a-placebo-controlled-randomized-trial
#1
Roghaieh Sadi, Sakineh Mohammad-Alizadeh-Charandabi, Mojgan Mirghafourvand, Yousef Javadzadeh, Afkham Ahmadi-Bonabi
BACKGROUND: Readiness of the cervix is required for successful induction of labor, and there are a number of ways in which this can be achieved. OBJECTIVES: The aim of the present study was to assess whether taking saffron orally could have an effect on the cervical readiness (primary outcome) and some delivery and neonatal outcomes (secondary outcomes) in women in the stage of term pregnancy. PATIENTS AND METHODS: In this double-blind trial, 50 women with a gestational age of 39 to 41 weeks, no indication of cesarean section, a Bishop's score of less than 4, who had plan to have vaginal delivery at Shohada hospital of Bonab, Iran were randomized into two groups receiving three 250mg saffron or placebo pills in 24 hours...
October 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28161698/adenine-rich-diet-is-not-a-surrogate-of-5-6-nephrectomy-in-rabbits
#2
Nans Florens, Sandrine Lemoine, Caroline C Pelletier, Maud Rabeyrin, Laurent Juillard, Christophe O Soulage
BACKGROUND: Animal models are important tools needed to understand the mechanisms underlying the progression of renal disease and to implement new therapeutic approaches. A non-surgical model of chronic kidney disease (CKD) developed by chemical nephrectomy using an adenine-enriched diet has been shown to be a robust model to induce kidney failure in mice and rats. The purpose of this study was to implement an adenine diet to induce CKD in rabbits. METHODS: Male New Zealand rabbits were fed for 4 weeks with a diet containing 0...
February 4, 2017: Nephron
https://www.readbyqxmd.com/read/28145859/phytochemical-properties-of-iranian-organic-saffron-stigma-antioxidant-anticancer-and-apoptotic-approaches
#3
M A Behdani, R Hoshyar
Agronomic and environmental factors affect quality and quantity of constituents in Saffron.  In this study, we compared chemical and antioxidant compounds of organic (OS) and inorganic (IOS) stigma of saffron and evaluated their anti-proliferative and apoptosis effects on cancer cells. Total antioxidant capacity of both saffron were characterized by FRAP, DPPH and Folin-Ciocalteu. HPLC and MTT methods were used to assay the amount of their secondary metabolites and anticancer effects, respectively. The expression of two apoptosis-related genes in treated cells evaluated by quantitative Real Time-PCR analysis...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28145852/safranal-prevents-rotenone-induced-oxidative-stress-and-apoptosis-in-an-in-vitro-model-of-parkinson-s-disease-through-regulating-keap1-nrf2-signaling-pathway
#4
P-K Pan, L-Y Qiao, X-N Wen
Safranal, a major constituent of saffron, possesses antioxidant and anti-apoptotic properties showing considerable neuroprotective effects. However, whether safranal shows therapeutic effect on Parkinson's disease (PD) remains unknown. In this study, we aimed to investigate the potential effect of safranal on PD using an in vitro model of PD induced by rotenone. We found that safranal significantly inhibited rotenone-induced cell death in a dose-dependent manner. Moreover, safranal also markedly suppressed the reactive oxygen species (ROS) generation and cell apoptosis induced by rotenone...
December 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28111973/efficacy-of-crocin-and-safranal-as-protective-agents-against-genotoxic-stress-induced-by-gamma-radiation-urethane-and-procarbazine-in-mice
#5
A Koul, S K Abraham
Crocin (CRO) and safranal (SAF) are bioactive constituents of saffron (dried stigma of Crocus sativus flower), an expensive spice with medicinal properties. Aqueous extract of saffron is known for its antigenotoxic effect against environmental genotoxins/carcinogens. However, there is need to identify saffron constituents responsible for this antigenotoxic effect. The aim of our investigation was to ascertain the role of CRO and SAF as inhibitors of in vivo genotoxic stress. For this purpose, Swiss albino mice were pretreated with CRO (50-mg/kg body weight (bw))/SAF (0...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28111683/effect-of-protic-ionic-liquid-nanostructure-on-phospholipid-vesicle-formation
#6
Saffron J Bryant, Kathleen Wood, Rob Atkin, Gregory G Warr
The formation of bilayer-based lyotropic liquid crystals and vesicle dispersions by phospholipids in a range of protic ionic liquids has been investigated by polarizing optical microscopy using isothermal penetration scans, differential scanning calorimetry, and small angle X-ray and neutron scattering. The stability and structure of both lamellar phases and vesicle dispersions is found to depend primarily on the underlying amphiphilic nanostructure of the ionic liquid itself. This finding has significant implications for the use of ionic liquids in soft and biological materials and for biopreservation, and demonstrates how vesicle structure and properties can be controlled through selection of cation and anion...
January 23, 2017: Soft Matter
https://www.readbyqxmd.com/read/28098452/a-perspective-on-crocus-sativus-l-saffron-constituent-crocin-a-potent-water-soluble-antioxidant-and-potential-therapy-for-alzheimer-s-disease
#7
John W Finley, Song Gao
Alzheimer's disease (AD) is the most common form of dementia, in which the death of brain cells causes memory loss and cognitive decline. Several factors are thought to play roles in the development and course of AD. Existing medical therapies only modestly alleviate and delay cognitive symptoms. Current research has been focused on developing antibodies to remove the aggregates of amyloid-β (Aβ) and tau protein. This approach has achieved removal of Aβ; however, no cognitive improvement in AD patients has been reported...
February 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28097042/the-relaxant-activity-of-safranal-in-isolated-rat-aortas-is-mediated-predominantly-via-an-endothelium-independent-mechanism-vasodilatory-mechanism-of-safranal
#8
Bibi Marjan Razavi, Mojtaba Alipoor Amanloo, Mohsen Imenshahidi, Hossein Hosseinzadeh
OBJECTIVES: Safranal is a pharmacologically active component of saffron and is responsible for the unique aroma of saffron. The hypotensive effect of safranal has been shown in previous studies. This study evaluates the mechanism for the vasodilatory effects induced by safranal on isolated rat aortas. METHODS: To study the vasodilatory effects of safranal (0.2, 0.4 and 0.8 mM), we contracted isolated rat thoracic aorta rings by using 10(-6)-M phenylephrine (PE) or 80-mM KCl...
December 2016: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28078246/the-effects-of-crocin-insulin-and-their-co-administration-on-the-heart-function-and-pathology-in-streptozotocin-induced-diabetic-rats
#9
Amir Abbas Farshid, Esmaeal Tamaddonfard, Masoumeh Moradi-Arzeloo, Navideh Mirzakhani
OBJECTIVE: Crocin is a saffron constituent with a potent anti-oxidant activity. The present study investigated the effects of crocin and insulin treatments (alone or in combination) on cardiac function and pathology in diabetic rats. MATERIALS AND METHODS: Diabetes was induced by intraperitoneal (i.p.) injection of streptozotocin (STZ, 50 mg/kg). Thereafter, crocin (5, 10 and 20 mg/kg, i.p.), subcutaneous (s.c.) injection of insulin (4 IU/kg) and their combination were administered for eight weeks...
November 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28078242/saffron-omics-the-challenges-of-integrating-omic-technologies
#10
REVIEW
Sameera Sastry Panchangam, Maryam Vahedi, Mohankumar Janardhan Megha, Anuj Kumar, Kaamini Raithatha, Raithatha Suravajhala, Pratap Reddy
Saffron is one of the highly exotic spices known for traditional values and antiquity. It is used for home décor besides serving as a colorant flavor and is widely known for medicinal value. Over the last few years, saffron has garnered a lot of interest due to its anti-cancer, anti-mutagenic, anti-oxidant and immunomodulatory properties. Integration of systems biology approaches with wide applications of saffron remains a growing challenge as new techniques and methods advance. Keeping in view of the dearth of a review summarizing the omics and systems biology of saffron, we bring an outline on advancements in integrating omic technologies, the medicinal plant has seen in recent times...
November 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28076854/open-angle-glaucoma-drug-development-pipeline-during-the-last-20-years-1995-2015
#11
André Vicente, Sylvie Prud'homme, Joana Ferreira, Luís Abegão Pinto, Ingeborg Stalmans
OBJECTIVES: To analyse drug development for open-angle glaucoma during the last 20 years. METHODS: Research was performed by referring to clinical trials registered at the International Clinical Trials Registry Platform (ICTRP). A search for the condition "open-angle glaucoma" with the intervention "drug" was performed. We included trials registered from 01/01/1995 to 01/01/2015, only involving studies in phases 1, 2, and 3. Only studies resorting to novel treatment strategies (either novel drugs or yet-untested fixed associations of approved medication) were considered...
January 12, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28071013/the-industrial-potential-of-herbs-and-spices-a-mini-review
#12
REVIEW
Katarzyna B Leja, Katarzyna Czaczyk
Herbs and spices have been used for food and medicinal purposes for centuries - the first recorded evidence of their use dates back to 1500BC and the Ebers Papyrus, which mentioned spices such as anise, mustard, saffron, cinnamon, and cassia. Now, in the 21st century, a variety of secondary compounds produced by plants are used in many fields of industry, such as food production (to improve taste, to provide vitamins and macro- and microelements, and also to inhibit food spoilage caused by foodborne bacteria), in medicine (in the treatment of various diseases; in chemoprevention and cancer therapy; as a source of natural antimicrobials for the treatment of infectious disease), and in pharmacology and cosmetology (in dietary supplements, and as a result of the demand for preservative-free cosmetics, to reduce the risk of methylparaben allergies)...
October 2016: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28045431/unraveling-massive-crocins-transport-and-accumulation-through-proteome-and-microscopy-tools-during-the-development-of-saffron-stigma
#13
Lourdes Gómez-Gómez, Verónica Parra-Vega, Alba Rivas-Sendra, Jose M Seguí-Simarro, Rosa Victoria Molina, Claudia Pallotti, Ángela Rubio-Moraga, Gianfranco Diretto, Alicia Prieto, Oussama Ahrazem
Crocins, the glucosides of crocetin, are present at high concentrations in saffron stigmas and accumulate in the vacuole. However, the biogenesis of the saffron chromoplast, the changes during the development of the stigma and the transport of crocins to the vacuole, are processes that remain poorly understood. We studied the process of chromoplast differentiation in saffron throughout stigma development by means of transmission electron microscopy. Our results provided an overview of a massive transport of crocins to the vacuole in the later developmental stages, when electron dense drops of a much greater size than plastoglobules (here defined "crocinoplast") were observed in the chromoplast, connected to the vacuole with a subsequent transfer of these large globules inside the vacuole...
January 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28030614/identification-and-cloning-of-differentially-expressed-soul-and-elip-genes-in-saffron-stigmas-using-a-subtractive-hybridization-approach
#14
Oussama Ahrazem, Javier Argandoña, Raquel Castillo, Ángela Rubio-Moraga, Lourdes Gómez-Gómez
Using a subtractive hybridization approach, differentially expressed genes involved in the light response in saffron stigmas were identified. Twenty-two differentially expressed transcript-derived fragments were cloned and sequenced. Two of them were highly induced by light and had sequence similarity to early inducible proteins (ELIP) and SOUL heme-binding proteins. Using these sequences, we searched for other family members expressed in saffron stigma. ELIP and SOUL are represented by small gene families in saffron, with four and five members, respectively...
2016: PloS One
https://www.readbyqxmd.com/read/28030380/potential-anticancer-role-of-colchicine-based-derivatives-an-overview
#15
Ashok Kumar, Parduman R Sharma, Dilip M Mondhe
Colchicine, the main alkaloid of the poisonous plant meadow saffron (Colchicum autumnale L.), is a classical drug used for the treatment of gout and familial Mediterranean fever. Although colchicine is not clinically used to treat cancer because of toxicity, it exerts antiproliferative effects through the inhibition of microtubule formation by blocking the cell cycle at the G2/M phase and triggering apoptosis. Colchicine can still be used as a lead compound for the generation of potential anticancer drugs. Thus, numerous analogues of colchicine have been synthesized in the hope of developing novel, useful drugs with more favourable pharmacological profiles...
March 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28025553/special-issue-saffron-crocus-sativus-l-omics-and-other-techniques-in-authenticity-quality-and-bioactivity-studies
#16
EDITORIAL
Maria Tsimidou, Petros A Tarantilis
n/a.
December 23, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27999238/the-effect-of-safranal-on-th1-th2-cytokine-balance
#17
Reza Feyzi, Mohammad Hossein Boskabady, Seyedeh Masoumeh Seyedhosseini Tamijani, Houshang Rafatpanah, Seyed Abdolrahim Rezaei
BACKGROUND: Several biological and medical benefits of Saffron, Crocus sativus (Iridaceae), have been demonstrated. However, mechanisms of actions for purified constituents are greatly unknown. OBJECTIVE: To examine the effects of Safranal, a main constituent of Saffron stigma, on cell viability and cytokine profile of peripheral blood mononuclear cells (PBMC) were examined. METHODS: Effects of Safranal at 0.1, 0.5 and 1 mM concentrations were evaluated on cell viability and production of interleukin 4 (IL-4), IL-10 and interferon-γ (IFN-γ) from non-stimulated and phytohemagglutinin (PHA) stimulated PBMCs, compared to 0...
December 2016: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/27987758/nanostructured-lipid-dispersions-for-topical-administration-of-crocin-a-potent-antioxidant-from-saffron-crocus-sativus-l
#18
Elisabetta Esposito, Markus Drechsler, Paolo Mariani, Anna Maria Panico, Venera Cardile, Lucia Crascì, Federica Carducci, Adriana Carol Eleonora Graziano, Rita Cortesi, Carmelo Puglia
Crocin, a potent antioxidant obtained from saffron, shows anticancer activity in in vivo models. Unfortunately unfavorable physicochemical features compromise its use in topical therapy. The present study describes the preparation and characterization of nanostructured lipid dispersions as drug delivery systems for topical administration of crocin and the evaluation of antioxidant and antiproliferative effects of crocin once encapsulated into nanostructured lipid dispersions. Nanostructured lipid dispersions based on monoolein in mixture with sodium cholate and sodium caseinate have been characterized by cryo-TEM and PCS...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987119/life-cycle-environmental-impacts-of-saffron-production-in-iran
#19
Majid Khanali, Saeid Shahvarooghi Farahani, Hamidreza Shojaei, Behzad Elhami
Saffron is regarded as an important crop in Iranian agricultural economics that needs to be investigated to produce the environmentally friendlier product. In the present study, saffron production as an important agricultural production system in Iran was evaluated thoroughly from an environmental point of view. Data were collected from saffron farmers in Southern Khorasan province of the country with face-to-face questionnaire method during cropping period of 2013-2014. The system boundary was considered from the production of raw input materials to the harvested saffron...
December 16, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27986289/characterisation-of-chemical-components-for-identifying-historical-chinese-textile-dyes-by-ultra-high-performance-liquid-chromatography-photodiode-array-electrospray-ionisation-mass-spectrometer
#20
Jing Han, Jantien Wanrooij, Maarten van Bommel, Anita Quye
This research makes the first attempt to apply Ultra High Performance Liquid Chromatography (UHPLC) coupled to both Photodiode Array detection (PDA) and Electrospray Ionisation Mass Spectrometer (ESI-MS) to the chemical characterisation of common textile dyes in ancient China. Three different extraction methods, respectively involving dimethyl sulfoxide (DMSO)-oxalic acid, DMSO and hydrochloric acid, are unprecedentedly applied together to achieve an in-depth understanding of the chemical composition of these dyes...
January 6, 2017: Journal of Chromatography. A
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