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https://www.readbyqxmd.com/read/29342057/audiologic-natural-history-of-small-volume-cochleovestibular-schwannomas-in-neurofibromatosis-type-2
#1
Alvin T deTorres, Carmen C Brewer, Chris K Zalewski, Kelly A King, Robert Walker, Gretchen C Scott, Ashok R Asthagiri, Prashant Chittiboina, Hung Jeffrey Kim
OBJECTIVE: To characterize the audiometric natural progression in patient-ears with small volume (<1,000 mm), treatment-naïve cochleovestibular schwannomas (CVSs) in Neurofibromatosis Type 2 (NF2). STUDY DESIGN: Prospective, longitudinal cohort study. SETTING: Quaternary medical research institute. PATIENTS: One hundred eleven ears in 71 NF2 patients with small, treatment-naïve CVSs observed from July 2006 to July 2016...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29334512/association-between-alcohol-use-and-angina-symptoms-among-outpatients-from-the-veterans-health-administration
#2
Emily C Williams, Chris L Bryson, Haili Sun, David H Au, Katharine A Bradley
BACKGROUND: Alcohol use is associated with angina incidence, but associations between alcohol use and experience of angina among patients with coronary artery disease (CAD) have not been described. METHODS: Outpatients with CAD from 7 clinics in the Veterans Health Administration were surveyed; alcohol use was measured using the validated Alcohol Use Disorders Identification Test-Consumption scores categorized into 6 groups: nondrinking, low-risk drinking, and mild, moderate, severe, and very severe unhealthy alcohol use...
January 12, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29326974/the-largest-deep-ocean-silicic-volcanic-eruption-of-the-past-century
#3
Rebecca Carey, S Adam Soule, Michael Manga, James White, Jocelyn McPhie, Richard Wysoczanski, Martin Jutzeler, Kenichiro Tani, Dana Yoerger, Daniel Fornari, Fabio Caratori-Tontini, Bruce Houghton, Samuel Mitchell, Fumihiko Ikegami, Chris Conway, Arran Murch, Kristen Fauria, Meghan Jones, Ryan Cahalan, Warren McKenzie
The 2012 submarine eruption of Havre volcano in the Kermadec arc, New Zealand, is the largest deep-ocean eruption in history and one of very few recorded submarine eruptions involving rhyolite magma. It was recognized from a gigantic 400-km2 pumice raft seen in satellite imagery, but the complexity of this event was concealed beneath the sea surface. Mapping, observations, and sampling by submersibles have provided an exceptionally high fidelity record of the seafloor products, which included lava sourced from 14 vents at water depths of 900 to 1220 m, and fragmental deposits including giant pumice clasts up to 9 m in diameter...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29322399/when-is-best-worst-best-a-comparison-of-best-worst-scaling-numeric-estimation-and-rating-scales-for-collection-of-semantic-norms
#4
Geoff Hollis, Chris Westbury
Large-scale semantic norms have become both prevalent and influential in recent psycholinguistic research. However, little attention has been directed towards understanding the methodological best practices of such norm collection efforts. We compared the quality of semantic norms obtained through rating scales, numeric estimation, and a less commonly used judgment format called best-worst scaling. We found that best-worst scaling usually produces norms with higher predictive validities than other response formats, and does so requiring less data to be collected overall...
January 10, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/29304055/is-intuition-really-cooperative-improved-tests-support-the-social-heuristics-hypothesis
#5
Ozan Isler, John Maule, Chris Starmer
Understanding human cooperation is a major scientific challenge. While cooperation is typically explained with reference to individual preferences, a recent cognitive process view hypothesized that cooperation is regulated by socially acquired heuristics. Evidence for the social heuristics hypothesis rests on experiments showing that time-pressure promotes cooperation, a result that can be interpreted as demonstrating that intuition promotes cooperation. This interpretation, however, is highly contested because of two potential confounds...
2018: PloS One
https://www.readbyqxmd.com/read/29299528/human-clade-2-3-4-4-a-h5n6-influenza-virus-lacks-mammalian-adaptation-markers-and-does-not-transmit-via-the-airborne-route-between-ferrets
#6
Sander Herfst, Chris K P Mok, Judith M A van den Brand, Stefan van der Vliet, Miruna E Rosu, Monique I Spronken, Zifeng Yang, Dennis de Meulder, Pascal Lexmond, Theo M Bestebroer, J S Malik Peiris, Ron A M Fouchier, Mathilde Richard
Since their emergence in 1997, A/H5N1 influenza viruses of the A/goose/Guangdong/1/96 lineage have diversified in multiple genetic and antigenic clades upon continued circulation in poultry in several countries in Eurasia and Africa. Since 2009, reassortant viruses carrying clade 2.3.4.4 hemagglutinin (HA) and internal and neuraminidase (NA) genes of influenza A viruses of different avian origin have been detected, yielding various HA-NA combinations, such as A/H5N1, A/H5N2, A/H5N3, A/H5N5, A/H5N6, and A/H5N8...
January 2018: MSphere
https://www.readbyqxmd.com/read/29299511/detection-of-cartilage-invasion-in-laryngeal-carcinoma-with-dynamic-contrast-enhanced-ct
#7
Jan W Dankbaar, Jaap Oosterbroek, Elise A Jager, Hugo W de Jong, Cornelis P Raaijmakers, Stefan M Willems, Chris H Terhaard, Marielle E Philippens, Frank A Pameijer
Objective: Staging of laryngeal cancer largely depends on cartilage invasion. Presence of cartilage invasion affects treatment choice and prognosis. On MRI and contrast-enhanced CT (CECT) it may be challenging to differentiate cartilage invasion from inflammation. The purpose of this study is to compare the diagnostic properties of dynamic contrast-enhanced CT (DCECT) and CECT for visual detection of cartilage invasion in laryngeal cancer. Study Design: Prospective cohort study...
December 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29258908/linear-regression-and-the-normality-assumption
#8
A F Schmidt, Chris Finan
OBJECTIVE: Researchers often perform arbitrary outcome transformations to fulfil the normality assumption of a linear regression model. This manuscript explains and illustrates that in large data settings, such transformations are often unnecessary, and worse, may bias model estimates. DESIGN: Linear regression assumptions are illustrated using simulated data and an empirical example on the relation between time since type 2 diabetes diagnosis and glycated haemoglobin (HbA1c)...
December 16, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29224760/post-tonsillectomy-dietary-advice-and-haemorrhage-risk-systematic-review
#9
REVIEW
Miles Bannister, Chris Thompson
OBJECTIVES: Tonsillectomy remains one of the commonest operations performed in children. Post-operative diet may affect post-tonsillectomy haemorrhage rate, although post-operative dietary advice varies. We undertook a systematic review of the published literature to assess if and how different post-operative diets were associated with differences in PTH rates following paediatric tonsillectomy, to provide an evidence base to inform individual otorhinolaryngologists' practice and for future guideline development...
December 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29221459/team-based-learning-tbl-in-the-medical-curriculum-better-than-pbl
#10
Annette Burgess, Jane Bleasel, Inam Haq, Chris Roberts, Roger Garsia, Tomas Robertson, Craig Mellis
BACKGROUND: Internationally, medical schools have long used a variety of approaches to develop hybrid Problem based learning (PBL) curricula. However, Team-based learning (TBL), has gained recent popularity in medical education. TBL maintains the advantages of small group teaching and learning, but in contrast to Problem-based learning (PBL), does not require large numbers of tutors. In 2016, TBL was introduced to Year 1 of the Sydney Medical Program (SMP).This study sought to compare students' perceptions of using TBL in place of PBL...
December 8, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29214740/a-prospective-multicentre-randomized-placebo-controlled-superiority-trial-in-patients-with-suspected-bacterial-endophthalmitis-after-cataract-surgery-on-the-adjuvant-use-of-intravitreal-dexamethasone-to-intravitreal-antibiotics
#11
Sonia Manning, Luana C Ugahary, Eric W Lindstedt, René J Wubbels, Jaap T van Dissel, Jan T G Jansen, Ivan Gan, Arnoud T van Goor, Carlien A Bennebroek, Dymph J van der Werf, Annette Ossewaarde-van Norel, Chris C Mayland Nielsen, Mauk Tilanus, Pieter R van den Biesen, Peter A Schellekens, Ellen La Heij, Koorosh Faridpooya, Koen van Overdam, Marc Veckeneer, Jan C van Meurs
PURPOSE: We aimed to determine whether intravitreal dexamethasone as an adjuvant to intravitreal antibiotics is beneficial in the treatment of suspected bacterial endophthalmitis after cataract surgery. METHODS: Randomized, placebo-controlled superiority trial in three tertiary referral centres in the Netherlands. Patients with suspected bacterial endophthalmitis within 6 weeks after cataract surgery were eligible. A diagnostic vitreous biopsy was taken for culture, and patients received intravitreal injections of 400 μg dexamethasone (without preservatives) or placebo, in addition to 0...
December 7, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29201547/decremental-responses-in-patients-with-motor-neuron-disease
#12
Mohammed H Alanazy, Janka Hegedus, Chris White, Lawrence Korngut
Objective: Involvement of the neuromuscular junction (NMJ) in amyotrophic lateral sclerosis (ALS) has been reported and is increasingly recognized as an important pathophysiological aspect. The relationship between decrement and clinical measures for possible application as a biomarker has not been comprehensively explored. Methods: We performed routine repetitive nerve stimulation (RNS) of three nerves on patients with ALS. We captured measures of muscle strength, grip strength, fatigability, and calculated slow vital capacity (SVC) rates of change assessing for associations...
November 2017: Brain and Behavior
https://www.readbyqxmd.com/read/29196286/does-proximal-control-need-a-new-definition-or-a-paradigm-shift-in-exercise-prescription-a-clinical-commentary
#13
EDITORIAL
Steven L Dischiavi, Alexis A Wright, Eric J Hegedus, Kevin R Ford, Chris Bleakley
No abstract text is available yet for this article.
December 1, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29171178/hiv-viral-load-monitoring-among-key-populations-in-low-and-middle-income-countries-challenges-and-opportunities
#14
Sheree R Schwartz, Matthew M Kavanagh, Jeremy Sugarman, Sunil S Solomon, Illiassou M Njindam, Kevin Rebe, Thomas C Quinn, Coumba Toure-Kane, Chris Beyrer, Stefan Baral
INTRODUCTION: Key populations bear a disproportionate HIV burden and have substantial unmet treatment needs. Routine viral load monitoring represents the gold standard for assessing treatment response at the individual and programme levels; at the population-level, community viral load is a metric of HIV programme effectiveness and can identify "hotspots" of HIV transmission. Nevertheless, there are specific implementation and ethical challenges to effectively operationalize and meaningfully interpret viral load data at the community level among these often marginalized populations...
November 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29163640/a-review-of-pathway-based-analysis-tools-that-visualize-genetic-variants
#15
REVIEW
Elisa Cirillo, Laurence D Parnell, Chris T Evelo
Pathway analysis is a powerful method for data analysis in genomics, most often applied to gene expression analysis. It is also promising for single-nucleotide polymorphism (SNP) data analysis, such as genome-wide association study data, because it allows the interpretation of variants with respect to the biological processes in which the affected genes and proteins are involved. Such analyses support an interactive evaluation of the possible effects of variations on function, regulation or interaction of gene products...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/29161845/spatially-implicit-modelling-of-disease-behaviour-interactions-in-the-context-of-non-pharmaceutical-interventions
#16
Notice Ringa, Chris T Bauch
Pair approximation models have been used to study the spread of infectious diseases in spatially distributed host populations, and to explore disease control strategies such as vaccination and case isolation. Here we introduce a pair approximation model of individual uptake of non-pharmaceutical interventions (NPIs) for an acute self-limiting infection, where susceptible individuals can learn the NPIs either from other susceptible individuals who are already practicing NPIs ("social learning"), or their uptake of NPIs can be stimulated by being neighbours of an infectious person ("exposure learning")...
April 1, 2018: Mathematical Biosciences and Engineering: MBE
https://www.readbyqxmd.com/read/29158446/drosophila-embryonic-type-ii-neuroblasts-origin-temporal-patterning-and-contribution-to-the-adult-central-complex
#17
Kathleen T Walsh, Chris Q Doe
Drosophila neuroblasts are an excellent model for investigating how neuronal diversity is generated. Most brain neuroblasts generate a series of ganglion mother cells (GMCs) that each make two neurons (type I lineage), but sixteen brain neuroblasts generate a series of intermediate neural progenitors (INPs) that each produce 4-6 GMCs and 8-12 neurons (type II lineage). Thus, type II lineages are similar to primate cortical lineages, and may serve as models for understanding cortical expansion. Yet the origin of type II neuroblasts remains mysterious: do they form in the embryo or larva? If they form in the embryo, do their progeny populate the adult central complex, as do the larval type II neuroblast progeny? Here we present molecular and clonal data showing that all type II neuroblasts form in the embryo, produce INPs, and express known temporal transcription factors...
November 20, 2017: Development
https://www.readbyqxmd.com/read/29142019/molecular-imaging-of-glut1-and-glut5-in-breast-cancer-a-multitracer-pet-imaging-study-in-mice
#18
Melinda Wuest, Ingrit Hamann, Vincent Bouvet, Darryl Glubrecht, Alison Marshall, Brendan Trayner, Olivier Soueidan, Daniel Krys, Michael Wagner, Chris Cheeseman, Frederick West, Frank Wuest
Use of [18F]FDG-PET in clinical breast cancer (BC) imaging is limited mainly due to insufficient expression levels of GLUT1 in up to 50% of all patients. Fructose-specific facilitative hexose transporter GLUT5 represents an alternative biomarker for PET imaging of hexose metabolism in BC. The goal of the present study was to compare uptake characteristics of selected hexose-based PET radiotracers in murine BC model EMT6. Uptake of 1-deoxy-1-[18F]fluoro-D-fructose (1-[18F]FDF), 6-deoxy-6-[18F]fluoro-D-fructose (6-[18F]FDF), 1-deoxy-1-[18F]fluoro-2,5-anhydro-mannitol (1-[18F]FDAM), 2-deoxy-2-[18F]fluoro-D-glucose (2-[18F]FDG) and 6-deoxy-6-[18F]fluoro-D-glucose (6-[18F]FDG) was studied in EMT6 cells, tumors and muscle and correlated to GLUT1 and GLUT5 expression levels...
November 15, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/29140134/a-nutrition-recovery-station-following-recreational-exercise-improves-fruit-consumption-but-does-not-influence-fluid-recovery
#19
Ben Desbrow, Katelyn Barnes, Caroline Young, Gregory R Cox, Chris Irwin
Immediate post-exercise access to fruit/fluid via a recovery "station" is a common feature of mass participation sporting events. Yet little evidence exists examining their impact on subsequent dietary intake. The aim of this study was to determine if access to fruit/water/sports drinks within a recovery station significantly alters dietary and fluid intakes in the immediate post-exercise period and influences hydration status the next morning. 127 (79 males) healthy participants (mean±SD, age=22.5±3.5y, body mass (BM)=73±13kg) completed two self-paced morning 10km runs separated by 1 week...
November 15, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29134577/perspective-taking-and-theory-of-mind-in-hide-and-seek
#20
Chris N H Street, Walter F Bischof, Alan Kingstone
Does theory of mind play a significant role in where people choose to hide an item or where they search for an item that has been hidden? Adapting Anderson's "Hide-Find Paradigm" Anderson et al. (Action, Perception and Performance, 76, 907-913, 2014) participants viewed homogenous or popout visual arrays on a touchscreen table. Their task was to indicate where in the array they would hide an item, or to search for an item that had been hidden, by either a friend or a foe. Critically, participants believed that their sitting location at the touchtable was the same as-or opposite to-their partner's location...
November 13, 2017: Attention, Perception & Psychophysics
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