keyword
MENU ▼
Read by QxMD icon Read
search

Chris Doe

keyword
https://www.readbyqxmd.com/read/28330744/the-addition-of-supervised-physiotherapy-sessions-for-management-of-acute-ankle-sprain-does-not-aid-recovery-more-than-providing-standardised-written-instruction-about-early-management-commentary
#1
https://www.readbyqxmd.com/read/28302126/systematic-meta-review-of-supported-self-management-for-asthma-a-healthcare-perspective
#2
Hilary Pinnock, Hannah L Parke, Maria Panagioti, Luke Daines, Gemma Pearce, Eleni Epiphaniou, Peter Bower, Aziz Sheikh, Chris J Griffiths, Stephanie J C Taylor
BACKGROUND: Supported self-management has been recommended by asthma guidelines for three decades; improving current suboptimal implementation will require commitment from professionals, patients and healthcare organisations. The Practical Systematic Review of Self-Management Support (PRISMS) meta-review and Reducing Care Utilisation through Self-management Interventions (RECURSIVE) health economic review were commissioned to provide a systematic overview of supported self-management to inform implementation...
March 17, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28300572/the-potential-role-of-aspiration-in-the-asthmatic-airway
#3
Eoin B Hunt, Chris Ward, Stephen Power, Ashley Sullivan, Jeffrey Pearson, Susan Lapthorne, Paul M O'Byrne, Joseph Eustace, Barry J Plant, Michael M Maher, John MacSharry, Desmond M Murphy
BACKGROUND: Many asthmatics remain sub-optimally controlled despite current treatments. Reasons include comorbidities that could aggravate asthma, including gastro-esophageal reflux (GER). We aimed to investigate whether aspiration occurs in asthmatic patients and if so does it correlate with asthma control. METHODS: Patients had ACQ-7, FeNO, and spirometry performed to characterize their level of asthma control. Barium swallow with provocation was performed to assess for predisposition to aspiration...
March 11, 2017: Chest
https://www.readbyqxmd.com/read/28289799/does-affective-touch-influence-the-virtual-reality-full-body-illusion
#4
Jutta R de Jong, Anouk Keizer, Manja M Engel, H Chris Dijkerman
The sense of how we experience our physical body as our own represents a fundamental component of human self-awareness. Body ownership can be studied with bodily illusions which are generated by inducing a visuo-tactile conflict where individuals experience illusionary ownership over a fake body or body part, such as a rubber hand. Previous studies showed that different types of touch modulate the strength of experienced ownership over a rubber hand. Specifically, participants experienced more ownership after the rubber hand illusion was induced through affective touch vs non-affective touch...
March 13, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28287700/price-for-opening-the-transient-specificity-pocket-in-human-aldose-reductase-upon-ligand-binding-structural-thermodynamic-kinetic-and-computational-analysis
#5
Chris Rechlin, Frithjof Scheer, Felix Terwesten, Tobias Wulsdorf, Ewa Pol, Veronica Fridh, Philipp Toth, Wibke E Diederich, Andreas Heine, Gerhard Klebe
Insights into the thermodynamic and kinetic signature of the transient opening of a protein-binding pocket are presented resulting from accommodation of suitable substituents attached to a given parent ligand scaffold. As target, we selected human aldose reductase, an enzyme involved in development of late-stage diabetic complications. To recognize a large scope of substrate molecules, this reductase opens a transient specificity pocket. The pocket-opening step was studied by X-ray crystallography, microcalorimetry and surface plasmon resonance using a narrow series of 2-carbamoyl-phenoxy-acetic acid derivatives...
March 13, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28284200/detection-in-blood-of-autoantibodies-to-tumour-antigens-as-a-case-finding-method-in-lung-cancer-using-the-earlycdt%C3%A2-lung-test-ecls-study-protocol-for-a-randomized-controlled-trial
#6
F M Sullivan, Eoghan Farmer, Frances S Mair, Shaun Treweek, Denise Kendrick, Cathy Jackson, Chris Robertson, Andrew Briggs, Colin McCowan, Laura Bedford, Ben Young, Kavita Vedhara, Stephanie Gallant, Roberta Littleford, John Robertson, Herb Sewell, Alistair Dorward, Joseph Sarvesvaran, Stuart Schembri
BACKGROUND: Lung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in the earliest stages of the disease which may allow tumour detection at an earlier stage thus altering prognosis. The primary research question is: Does using the EarlyCDT®-Lung Test to identify those at high risk of lung cancer, followed by X-ray and computed tomography (CT) scanning, reduce the incidence of patients with late-stage lung cancer (III & IV) or unclassified presentation (U) at diagnosis, compared to standard practice? METHODS: A randomised controlled trial of 12 000 participants in areas of Scotland targeting general practices serving patients in the most deprived quintile of the Scottish Index of Multiple Deprivation...
March 11, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28279905/does-equality-legislation-reduce-intergroup-differences-religious-affiliation-socio-economic-status-and-mortality-in-scotland-and-northern-ireland-a-cohort-study-of-400-000-people
#7
David M Wright, Michael Rosato, Gillian Raab, Chris Dibben, Paul Boyle, Dermot O'Reilly
Religion frequently indicates membership of socio-ethnic groups with distinct health behaviours and mortality risk. Determining the extent to which interactions between groups contribute to variation in mortality is often challenging. We compared socio-economic status (SES) and mortality rates of Protestants and Catholics in Scotland and Northern Ireland, regions in which interactions between groups are profoundly different. Crucially, strong equality legislation has been in place for much longer and Catholics form a larger minority in Northern Ireland...
March 6, 2017: Health & Place
https://www.readbyqxmd.com/read/28276445/high-frequency-coastal-overwash-deposits-from-phra-thong-island-thailand
#8
Chris Gouramanis, Adam D Switzer, Kruawun Jankaew, Charles S Bristow, Dat T Pham, Sorvigenaleon R Ildefonso
The 26(th) December 2004 Indian Ocean Tsunami (IOT) emanated from an Mw 9.2 earthquake that generated a 1600 km-long rupture along the Sumatran Megathrust and generated tsunami waves up to 30 m high. The IOT directly impacted the Bay of Bengal and east Africa, with over 283,000 people perishing. At the time, this catastrophic event was considered unprecedented and sparked intense investigations to test this claim. It is now believed that four pre-2004 IOT events have occurred in the last 2500 years, recurring every 550 to 700 years...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28265523/reanalyzing-head-et-al-2015-investigating-the-robustness-of-widespread-p-hacking
#9
Chris H J Hartgerink
Head et al. (2015) provided a large collection of p-values that, from their perspective, indicates widespread statistical significance seeking (i.e., p-hacking). This paper inspects this result for robustness. Theoretically, the p-value distribution should be a smooth, decreasing function, but the distribution of reported p-values shows systematically more reported p-values for .01, .02, .03, .04, and .05 than p-values reported to three decimal places, due to apparent tendencies to round p-values to two decimal places...
2017: PeerJ
https://www.readbyqxmd.com/read/28260151/the-effects-of-acute-copper-and-ammonia-challenges-on-ammonia-and-urea-excretion-by-the-blue-crab-callinectes-sapidus
#10
Alex M Zimmer, Marianna Basso Jorge, Chris M Wood, Camila M G Martins, Adalto Bianchini
Copper (Cu) is a persistent environmental contaminant that elicits several physiological disturbances in aquatic organisms, including a disruption in ammonia regulation. We hypothesized that exposure to Cu in a model crustacean (blue crab, Callinectes sapidus) acclimated to brackish water (2 ppt) would lead to hyperammonemia by stimulating an increase in ammonia production and/or by inhibiting ammonia excretion. We further hypothesized that urea production would represent an ammonia detoxification strategy in response to Cu...
April 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28249115/lateral-ge-diffusion-during-oxidation-of-si-sige-fins
#11
William M Brewer, Yan Xin, Chris Hatem, David R Diercks, Van Q Truong, Kevin S Jones
This paper reports on the unusual diffusion behavior of Ge during oxidation of a multilayer Si/SiGe fin. It is observed that oxidation surprisingly results in the formation of vertically stacked Si nanowires encapsulated in defect free epitaxial strained SixGe1-x. High angle annular dark field scanning transmission electron microscopy (HAADF-STEM) shows that extremely enhanced diffusion of Ge occurs along the vertical Si/SiO2 oxidizing interface and is responsible for the encapsulation process. Further oxidation fully encapsulates the Si layers in defect free single crystal SixGe1-x (x up to 0...
March 1, 2017: Nano Letters
https://www.readbyqxmd.com/read/28238607/leydig-cell-hyperplasia-in-children-case-series-and-review
#12
REVIEW
Nicole Mennie, Sebastian K King, Mohan Marulaiah, Peter Ferguson, Yves Heloury, Chris Kimber
INTRODUCTION: Leydig cell hyperplasia (LCH) and Leydig cell tumours (LCTs) in children are rare, typically presenting with precocious puberty. Previously, orchidectomy was the routine management; however, more recently, testis-sparing surgery has been performed with good results. We present a series of unusual presentations of LCH, raising new management questions, and a review of the literature regarding LCH and LCT in children. STUDY DESIGN: We performed a literature search using Ovid Medline, PubMed, and Google Scholar, producing 456 articles...
February 10, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28226227/protective-and-harmful-immunity-to-rsv-infection
#13
Peter J M Openshaw, Chris Chiu, Fiona J Culley, Cecilia Johansson
Respiratory syncytial virus (RSV) is an exceptional mucosal pathogen. It specializes in infection of the ciliated respiratory epithelium, causing disease of variable severity with little or no direct systemic effects. It infects virtually all children by the age of three years and then repeatedly infects throughout life; this it does despite relatively slight variations in antigenicity, apparently by inducing selective immunological amnesia. Inappropriate or dysregulated responses to RSV can be pathogenic, causing disease-enhancing inflammation that contributes to short- and long-term effects...
February 6, 2017: Annual Review of Immunology
https://www.readbyqxmd.com/read/28219774/dynamic-causal-modelling-revisited
#14
K J Friston, Katrin H Preller, Chris Mathys, Hayriye Cagnan, Jakob Heinzle, Adeel Razi, Peter Zeidman
This paper revisits the dynamic causal modelling of fMRI timeseries by replacing the usual (Taylor) approximation to neuronal dynamics with a neural mass model of the canonical microcircuit. This provides a generative or dynamic causal model of laminar specific responses that can generate haemodynamic and electrophysiological measurements. In principle, this allows the fusion of haemodynamic and (event related or induced) electrophysiological responses. Furthermore, it enables Bayesian model comparison of competing hypotheses about physiologically plausible synaptic effects; for example, does attentional modulation act on superficial or deep pyramidal cells - or both? In this technical note, we describe the resulting dynamic causal model and provide an illustrative application to the attention to visual motion dataset used in previous papers...
February 17, 2017: NeuroImage
https://www.readbyqxmd.com/read/28208251/rapid-method-development-in-hydrophilic-interaction-liquid-chromatography-for-pharmaceutical-analysis-using-a-combination-of-quantitative-structure-retention-relationships-and-design-of-experiments
#15
Maryam Taraji, Paul R Haddad, Ruth I J Amos, Mohammad Talebi, Roman Szucs, John W Dolan, Chris A Pohl
A design-of-experiment (DoE) model was developed, able to describe the retention times of a mixture of pharmaceutical compounds in hydrophilic interaction liquid chromatography (HILIC) under all possible combinations of acetonitrile content, salt concentration, and mobile-phase pH with R(2) > 0.95. Further, a quantitative structure-retention relationship (QSRR) model was developed to predict retention times for new analytes, based only on their chemical structures, with a root-mean-square error of prediction (RMSEP) as low as 0...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28195448/mitochondrion-anchoring-photosensitizer-with-aggregation-induced-emission-characteristics-synergistically-boosts-the-radiosensitivity-of-cancer-cells-to-ionizing-radiation
#16
Chris Y Y Yu, Huae Xu, Shenglu Ji, Ryan T K Kwok, Jacky W Y Lam, Xiaolin Li, Sunil Krishnan, Dan Ding, Ben Zhong Tang
The first mitochondrion-anchoring photosensitizer that specifically generates singlet oxygen ((1) O2 ) in mitochondria under white light irradiation that can serve as a highly effective radiosensitizer is reported here, significantly sensitizing cancer cells to ionizing radiation. An aggregation-induced emission luminogen (AIEgen), namely DPA-SCP, is rationally designed with α-cyanostilbene as a simple building block to reveal AIE, diphenylamino (DPA) group as a strong electron donating group to benefit red emission and efficient light-controlled (1) O2 generation, as well as a pyridinium salt as the targeting moiety to ensure specific mitochondrial localization...
February 13, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28192762/neural-mass-models-describing-possible-origin-of-the-excessive-beta-oscillations-correlated-with-parkinsonian-state
#17
Chen Liu, Yulin Zhu, Fei Liu, Jiang Wang, Huiyan Li, Bin Deng, Chris Fietkiewicz, Kenneth A Loparo
In Parkinson's disease, the enhanced beta rhythm is closely associated with akinesia/bradykinesia and rigidity. An increase in beta oscillations (12-35 Hz) within the basal ganglia (BG) nuclei does not proliferate throughout the cortico-basal ganglia loop in uniform fashion; rather it can be subdivided into two distinct frequency bands, i.e. the lower beta (12-20 Hz) and upper beta (21-35 Hz). A computational model of the excitatory and inhibitory neural network that focuses on the population properties is proposed to explore the mechanism underlying the pathological beta oscillations...
January 30, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28191016/incidence-and-molecular-characterization-of-hepatitis-e-virus-from-swine-in-eastern-cape-south-africa
#18
Olusesan Adeyemi Adelabu, Benson Chuks Iweriebor, U U Nwodo, Larry Chikwelu Obi, Anthony Ifeanyi Okoh
Hepatitis E virus-mediated infection is a serious public health concern in economically developing nations of the world. Globally, four major genotypes of HEV have been documented. Hepatitis E has been suggested to be zoonotic owing to the increase of evidence through various studies. Thus far, this paper reports on prevalence of hepatitis E virus among swine herd in selected communal and commercial farms in the Eastern Cape Province of South Africa. A total of 160 faecal samples were collected from swine herds in Amathole and Chris Hani District Municipalities of Eastern Cape Province for the presence of HEV...
2017: Advances in Virology
https://www.readbyqxmd.com/read/28177891/tumour-infiltrating-regulatory-t-cell-density-before-neoadjuvant-chemoradiotherapy-for-rectal-cancer-does-not-predict-treatment-response
#19
Melanie J McCoy, Chris Hemmings, Chidozie C Anyaegbu, Stephanie J Austin, Tracey F Lee-Pullen, Timothy J Miller, Max K Bulsara, Nikolajs Zeps, Anna K Nowak, Richard A Lake, Cameron F Platell
Neoadjuvant (preoperative) chemoradiotherapy (CRT) decreases the risk of rectal cancer recurrence and reduces tumour volume prior to surgery. However, response to CRT varies considerably between individuals and factors associated with response are poorly understood. Foxp3+ regulatory T cells (Tregs) inhibit anti-tumour immunity and may limit any response to chemotherapy and radiotherapy. We have previously reported that a low density of Tregs in the tumour stroma following neoadjuvant CRT for rectal cancer is associated with improved tumour regression...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28162251/reliability-and-utility-of-citizen-science-reef-monitoring-data-collected-by-reef-check-australia-2002-2015
#20
Terence Done, Chris Roelfsema, Andrew Harvey, Laura Schuller, Jocelyn Hill, Marie-Lise Schläppy, Alexandra Lea, Anne Bauer-Civiello, Jennifer Loder
Reef Check Australia (RCA) has collected data on benthic composition and cover at >70 sites along >1000km of Australia's Queensland coast from 2002 to 2015. This paper quantifies the accuracy, precision and power of RCA benthic composition data, to guide its application and interpretation. A simulation study established that the inherent accuracy of the Reef Check point sampling protocol is high (<±7% error absolute), in the range of estimates of benthic cover from 1% to 50%. A field study at three reef sites indicated that, despite minor observer- and deployment-related biases, the protocol does reliably document moderate ecological changes in coral communities...
February 2, 2017: Marine Pollution Bulletin
keyword
keyword
72590
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"