Sang-Jin Park, Heeseon Park, Seng-Min Back, Young Ju Lee, Joung-Wook Seo, Dabi Kim, Jeong Hwa Lee, Chaewon Kwak, Kang-Hyun Han, Hwa-Young Son, Yong-Bum Kim
The emergence of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic, prompting rapid vaccine development. Although vaccines are effective, the occurrence of rare adverse events following vaccination highlights the necessity of determining whether the benefits outweigh the risks posed by the infection itself. The recombinant Vesicular Stomatitis Virus (rVSV) platform is a promising vector for vaccines against emerging viruses. However, limited studies have evaluated the genotoxicity and safety pharmacology of this viral vector vaccine, which is crucial to ensure the safety of vaccines developed using this platform...
April 12, 2024: Archives of Toxicology