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diabetes cancer survival mortality

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https://www.readbyqxmd.com/read/28293802/history-of-hypertension-heart-disease-and-diabetes-and-ovarian-cancer-patient-survival-evidence-from-the-ovarian-cancer-association-consortium
#1
Albina N Minlikeeva, Jo L Freudenheim, Rikki A Cannioto, J Brian Szender, Kevin H Eng, Francesmary Modugno, Roberta B Ness, Michael J LaMonte, Grace Friel, Brahm H Segal, Kunle Odunsi, Paul Mayor, Emese Zsiros, Barbara Schmalfeldt, Rüdiger Klapdor, Thilo Dӧrk, Peter Hillemanns, Linda E Kelemen, Martin Kӧbel, Helen Steed, Anna de Fazio, Susan J Jordan, Christina M Nagle, Harvey A Risch, Mary Anne Rossing, Jennifer A Doherty, Marc T Goodman, Robert Edwards, Keitaro Matsuo, Mika Mizuno, Beth Y Karlan, Susanne K Kjær, Estrid Høgdall, Allan Jensen, Joellen M Schildkraut, Kathryn L Terry, Daniel W Cramer, Elisa V Bandera, Lisa E Paddock, Lambertus A Kiemeney, Leon F Massuger, Jolanta Kupryjanczyk, Andrew Berchuck, Jenny Chang-Claude, Brenda Diergaarde, Penelope M Webb, Kirsten B Moysich
PURPOSE: Survival following ovarian cancer diagnosis is generally low; understanding factors related to prognosis could be important to optimize treatment. The role of previously diagnosed comorbidities and use of medications for those conditions in relation to prognosis for ovarian cancer patients has not been studied extensively, particularly according to histological subtype. METHODS: Using pooled data from fifteen studies participating in the Ovarian Cancer Association Consortium, we examined the associations between history of hypertension, heart disease, diabetes, and medications taken for these conditions and overall survival (OS) and progression-free survival (PFS) among patients diagnosed with invasive epithelial ovarian carcinoma...
March 14, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28286778/prognostic-relevance-and-function-of-msx2-in-colorectal-cancer
#2
Jiancheng Liu, Huaying An, Wei Yuan, Qiang Feng, Lianzhen Chen, Jie Ma
Colorectal cancer patients with diabetes had the high risks of total mortality. High expression of MSX2 is related to development of diabetes. There are few reports about the clinical implications and function of MSX2 in colorectal cancer (CRC). The purpose of this study is to investigate the relationship between the expression of MSX2 and clinical relevance and discover the possible mechanism of MSX2 in the development of CRC. Compared with adjacent tissues, the expression of MSX2 was higher in tumor tissues in both mRNA and protein levels (P < 0...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28281103/current-evidence-on-vitamin-d-deficiency-and-kidney-transplant-what-s-new
#3
REVIEW
Gerardo Sarno, Riccardo Nappi, Barbara Altieri, Giacomo Tirabassi, Emanuele Muscogiuri, Gianmaria Salvio, Stavroula A Paschou, Aristide Ferrara, Enrico Russo, Daniela Vicedomini, Cerbone Vincenzo, Andromachi Vryonidou, Silvia Della Casa, Giancarlo Balercia, Francesco Orio, Paride De Rosa
Kidney transplant is the treatment of choice for end-stage chronic kidney disease. Kidneys generate 1,25-dihydroxyvitamin D (calcitriol) from 25-hydroxyvitamin D (calcidiol) for circulation in the blood to regulate calcium levels. Transplant patients with low calcidiol levels have an increased risk of metabolic and endocrine problems, cardiovascular disease, type 2 diabetes mellitus, poor graft survival, bone disorders, cancer, and mortality rate. The recommended calcidiol level after transplant is at least 30 ng/mL (75 nmol/L), which could require 1000-3000 IU/d vitamin D3 to achieve...
March 9, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28274539/the-clinical-impact-of-major-comorbidities-on-idiopathic-pulmonary-fibrosis
#4
REVIEW
Atsushi Suzuki, Yasuhiro Kondoh
Idiopathic pulmonary fibrosis (IPF) is a progressive and devastating disease with a median survival time of 2-3 years after diagnosis. Patients with IPF exhibit distinct patterns of disease progression, and some patients display a more rapidly progressive clinical course. The clinical course of IPF may also include periods of acute deterioration, which are termed acute exacerbations. Patients with IPF frequently experience various comorbidities, such as pulmonary infection, emphysema, pulmonary hypertension, lung cancer, gastroesophageal reflux, cardiovascular disease, diabetes mellitus, and obstructive sleep apnea...
March 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28271076/metformin-improves-overall-survival-of-colorectal-cancer-patients-with-diabetes-a-meta-analysis
#5
REVIEW
Fanqiang Meng, Li Song, Wenyue Wang
Introduction. Diabetic population has a higher risk of colorectal cancer (CRC) incidence and mortality than nondiabetics. The role of metformin in CRC prognosis is still controversial. The meta-analysis aims to investigate whether metformin improves the survival of diabetic CRC patients. Methods. PubMed, EMBASE, and Cochrane Library were searched till July 1, 2016. Cohort studies were included. All articles were evaluated by Newcastle-Ottawa Scale. Hazard Ratios (HRs) with 95% confidence intervals (CIs) for each study were calculated and pooled HRs with corresponding 95% CIs were generated using the random-effects model...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28270890/an-elevated-hba1c-level-is-associated-with-short-term-adverse-outcomes-in-patients-with-gastrointestinal-cancer-and-type-2-diabetes-mellitus
#6
Yingchun Huang, Huazhen Zheng, Peicong Chen, Jin Yang, Shaomin Lin, Tingting Liu, Shanwei Chen, Siqiang Lu, Junlian Chen, Wenpu Chen, Nanhai Peng
BACKGROUND: Although an elevated hemoglobin A1c (HbAc1) level is an independent predictor of worse survival in patients with both digestive cancer and diabetes mellitus, its relationship to short-term prognosis in these patients has not been addressed. This study assessed this relationship in gastrointestinal cancer (GIC) patients with type 2 diabetes mellitus (T2DM). METHODS: A retrospective review of patients with GIC with or without T2DM from 2004 to 2014 was performed...
April 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28263132/the-need-for-androgen-deprivation-therapy-in-patients-with-intermediate-risk-prostate-cancer-treated-with-dose-escalated-external-beam-radiation-therapy
#7
Yanqun Dong, Karen J Ruth, Thomas M Churilla, Rosalia Viterbo, Mark L Sobczak, Marc C Smaldone, David Y T Chen, Robert G Uzzo, Mark H Hallman, Eric M Horwitz
INTRODUCTION: To evaluate if androgen deprivation therapy (ADT) improves outcomes for patients with localized, intermediate-risk prostate cancer treated with definitive external beam radiation therapy (EBRT) in the dose-escalated era. MATERIALS AND METHODS: This is a retrospective study using a single institutional database. We included patients with localized, intermediate-risk prostate cancer treated with dose-escalated radiation therapy (RT) with 3D conformal radiotherapy or intensity-modulated radiotherapy (74-80 Gy in daily fraction of 1...
February 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28209242/survival-of-macrovascular-disease-chronic-kidney-disease-chronic-respiratory-disease-cancer-and-smoking-in-patients-with-type-2-diabetes-biobank-japan-cohort
#8
Hiroshi Yokomichi, Akiko Nagai, Makoto Hirata, Yutaka Kiyohara, Kaori Muto, Toshiharu Ninomiya, Koichi Matsuda, Yoichiro Kamatani, Akiko Tamakoshi, Michiaki Kubo, Yusuke Nakamura, Zentaro Yamagata
BACKGROUND: The number of patients with diabetes is increasing worldwide. Macrovascular disease, chronic kidney disease, chronic respiratory disease, cancer and smoking frequently accompany type 2 diabetes. Few data are available related to mortality of Asians with diabetes associated with these serious comorbidities. The present study aimed to quantify the excess mortality risks of type 2 diabetic patients with comorbidities. METHODS: We analysed the available records of 30,834 Japanese patients with type 2 diabetes from the BioBank Japan Project between 2003 and 2007...
March 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28203070/determining-prognosis-in-acute-exacerbation-of-copd
#9
Yves Flattet, Nicolas Garin, Jacques Serratrice, Arnaud Perrier, Jérome Stirnemann, Sebastian Carballo
BACKGROUND: Acute exacerbations are the leading causes of hospitalization and mortality in patients with COPD. Prognostic tools for patients with chronic COPD exist, but there are scarce data regarding acute exacerbations. We aimed to identify the prognostic factors of death and readmission after exacerbation of COPD. METHODS: This was a retrospective study conducted in the Department of Internal Medicine of Geneva University Hospitals. All patients admitted to the hospital with a diagnosis of exacerbation of COPD between 2008 and 2011 were included...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28163045/analysis-of-preoperative-metabolic-risk-factors-affecting-the-prognosis-of-patients-with-esophageal-squamous-cell-carcinoma-the-fujian-prospective-investigation-of-cancer-fiesta-study
#10
Feng Peng, Dan Hu, Xiandong Lin, Gang Chen, Binying Liang, Hejun Zhang, Xiaoqun Dong, Jinxiu Lin, Xiongwei Zheng, Wenquan Niu
Some metabolic factors have been shown to be associated with an increased risk of esophageal cancer; however the association with its prognosis is rarely reported. Here, we assessed the prediction of preoperative metabolic syndrome and its single components for esophageal cancer mortality by analyzing a subset of data from the ongoing Fujian prospective investigation of cancer (FIESTA) study. Between 2000 and 2010, patients who underwent three-field lymphadenectomy were eligible for inclusion. Blood/tissue specimens, demographic and clinicopathologic data were collected at baseline...
February 2017: EBioMedicine
https://www.readbyqxmd.com/read/28158300/impact-of-diabetes-mellitus-on-clinical-outcomes-of-pancreatic-cancer-after-surgical-resection-a-systematic-review-and-meta-analysis
#11
Xinghua Lv, Wenhui Qiao, Yufang Leng, Lupeng Wu, Yanming Zhou
BACKGROUND AND OBJECTIVE: Diabetes mellitus (DM) is a risk factor for pancreatic cancer but its impact on postoperative outcomes and long-term survival after cancer resection remains controversial. A meta-analysis of published studies was conducted to address this issue. METHODS: An extensive electronic search of four databases was performed for relevant articles. Data were processed for meta-analysis using Review Manager version 5.1. RESULTS: Seventeen observational studies involving 5407 patients were subjected to the analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28107755/optimal-glycemic-target-level-for-colon-cancer-patients-with-diabetes
#12
Shin Jun Lee, Jae Hyun Kim, Seun Ja Park, So Young Ock, Su Kyoung Kwon, Young Sik Choi, Bu Kyung Kim
AIMS: The aim of this study was to evaluate the differences in mortality among colon cancer patients with or without diabetes and to determine optimal glycemic target level for colon cancer patients with diabetes. METHODS: A total of 741 patients with colon cancer between April 1999 and December 2010 were reviewed. The non-diabetes group had a fasting plasma glucose <126mg/dL, and the diabetes group had a fasting plasma glucose ⩾126mg/dL. Patients with diabetes were further divided based on glycemic control into either the uncontrolled subgroup (HbA1c ⩾8%) or the well-controlled subgroup (HbA1c <8%)...
February 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28103573/prognostic-role-of-metformin-intake-in-diabetic-patients-with-colorectal-cancer-an-updated-qualitative-evidence-of-cohort-studies
#13
Lili Du, Mingli Wang, Yingying Kang, Bo Li, Min Guo, Zhifeng Cheng, Changlong Bi
Several observational studies have shown that metformin can modify the risk and survival of colorectal cancer (CRC) in patients with diabetes mellitus, although the magnitude of this relationship has not been determined. We conducted an updated systematic review and meta-analysis to analyze the association between metformin and CRC mortality and searched relevant databases up to July 2016. The primary outcome was overall survival (OS). Secondary outcomes were cancer-specific survival (CS) and disease-free survival (DFS)...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28077783/association-between-metformin-use-and-mortality-in-patients-with-type-2-diabetes-mellitus-and-localized-resectable-pancreatic-cancer-a-nationwide-population-based-study-in-korea
#14
Won Il Jang, Mi-Sook Kim, Shin Hee Kang, Ae Jung Jo, Yun Jung Kim, Ha Jin Tchoe, Chan Mi Park, Hyo Jeong Kim, Jin A Choi, Hyung Jin Choi, Eun-Kyung Paik, Young Seok Seo, Hyung Jun Yoo, Jin-Kyu Kang, Chul Ju Han, Yeon Ju Kim, Sang Beom Kim, Min Jung Ko
BACKGROUND: Preclinical studies support an antitumor effect of metformin. However, clinical studies have conflicting results and metformin's effect remains controversial. The aim of this study was to evaluate metformin's effect on clinical outcomes in diabetic patients with pancreatic cancer treated with curative resection. RESULTS: A total of 764 patients underwent curative resection, met none of the exclusion criteria, and were prescribed oral hypoglycemic agents...
February 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28017810/access-to-quaternary-care-surgery-implications-for-accountable-care-organizations
#15
J Hunter Mehaffey, Robert B Hawkins, Matthew G Mullen, Max O Meneveau, Bruce Schirmer, Irving L Kron, R Scott Jones, Peter T Hallowell
BACKGROUND: Accountable care organizations (ACOs) attempt to provide the most efficient and effective care to patients within a region. We hypothesized that patients who undergo surgery closer to home have improved survival due to proximity of preoperative and post-discharge care. STUDY DESIGN: All (17,582) institutional American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP) patients with a documented ZIP code and predicted risk, who underwent surgery at our institution (2005 to 2014), were evaluated...
December 23, 2016: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/27998911/life-expectancy-and-cause-specific-mortality-in-type-2-diabetes-a-population-based-cohort-study-quantifying-relationships-in-ethnic-subgroups
#16
Alison K Wright, Evangelos Kontopantelis, Richard Emsley, Iain Buchan, Naveed Sattar, Martin K Rutter, Darren M Ashcroft
OBJECTIVES: This study 1) investigated life expectancy and cause-specific mortality rates associated with type 2 diabetes and 2) quantified these relationships in ethnic subgroups. RESEARCH DESIGN AND METHODS: This was a cohort study using Clinical Practice Research Datalink data from 383 general practices in England with linked hospitalization and mortality records. A total of 187,968 patients with incident type 2 diabetes from 1998 to 2015 were matched to 908,016 control subjects...
December 20, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27995338/erratum-to-the-need-for-differentiating-diabetes-specific-mortality-from-total-mortality-when-comparing-metformin-with-insulin-regarding-cancer-survival
#17
Min Wei, Yu Liu, Chunhong Wang, Chuanhua Yu, Dejia Li, Wei Zhou, Zhi-Jiang Zhang
No abstract text is available yet for this article.
December 19, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27978516/prognostic-significance-of-dementia-in-older-adults-with-solid-tumors
#18
Supakanya Wongrakpanich, Amy Hurst, Jean Bustamante, Nellowe Candelario, Sylvia Biso, Wikrom Chaiwatcharayut, Claudia Dourado, Andrew Rosenzweig
BACKGROUND: The public health burden of cancer and dementia in the geriatric population is well documented. There is limited data on how dementia predicts mortality among geriatric patients with solid tumors. The objective of this study is to determine the prognostic significance of dementia on survival in patients with solid tumors. METHODS: We performed a 5-year retrospective study on elderly subjects aged ≥60 years with and without dementia that were diagnosed with solid tumors...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27957429/relationship-between-level-of-hba1c-and-breast-cancer
#19
Fariba Jousheghany, Joshua Phelps, Tina Crook, Reza Hakkak
BACKGROUND: Diabetes and cancer are public health issues worldwide; studies have shown that diabetes is related to increased breast cancer mortality. The purpose of this study was to examine associations between HbA1C and obesity with tumor stage and mortality among breast cancer patients. METHODS: Data for 82 patients with breast cancer (36-89 years of age, diagnosed /treated 1999-2009) were provided by the University of Arkansas for Medical Sciences (UAMS) Data Trust Warehouse...
December 2016: BBA Clinical
https://www.readbyqxmd.com/read/27956793/epidemiology-of-pancreatic-cancer
#20
REVIEW
Milena Ilic, Irena Ilic
Cancer of the pancreas remains one of the deadliest cancer types. Based on the GLOBOCAN 2012 estimates, pancreatic cancer causes more than 331000 deaths per year, ranking as the seventh leading cause of cancer death in both sexes together. Globally, about 338000 people had pancreatic cancer in 2012, making it the 11(th) most common cancer. The highest incidence and mortality rates of pancreatic cancer are found in developed countries. Trends for pancreatic cancer incidence and mortality varied considerably in the world...
November 28, 2016: World Journal of Gastroenterology: WJG
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