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Pentraxin 3

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https://www.readbyqxmd.com/read/29783932/the-association-of-angiogenic-factors-and-chronic-kidney-disease
#1
Christopher E Anderson, L Lee Hamm, Gem Batuman, Damodar R Kumbala, Chung-Shiuan Chen, Swapna G Kallu, Ravi Siriki, Shilpa Gadde, Myra A Kleinpeter, N Kevin Krane, Eric E Simon, Jiang He, Jing Chen
BACKGROUND: There are limited data on the associations of circulating angiogenic factors with chronic kidney disease (CKD). We investigate the associations of circulating vascular endothelial growth factor (VEGF)-A, angiopoietin-1, angiopoietin-1/VEGF-A ratio, VEGF receptor 1 (VEGFR-1), VEGFR-2, and pentraxin-3 with CKD. METHODS: We recruited 201 patients with CKD and 201 community controls without CKD from the greater New Orleans area. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1...
May 21, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29777721/pentraxins-crp-i-and-crp-ii-are-post-translationally-deiminated-and-differ-in-tissue-specificity-in-cod-gadus-morhua-l-ontogeny
#2
Bergljót Magnadóttir, Polly Hayes, Berglind Gísladóttir, Birkir Þór Bragason, Mariya Hristova, Anthony P Nicholas, Sigríður Guðmundsdóttir, Sigrun Lange
Pentraxins are fluid phase pattern recognition molecules that form an important part of the innate immune defence and are conserved between fish and human. In Atlantic cod (Gadus morhua L.), two pentraxin-like proteins have been described, CRP-I and CRP-II. Here we show for the first time that these two CRP forms are post-translationally deiminated (an irreversible conversion of arginine to citrulline) and differ with respect to tissue specific localisation in cod ontogeny from 3 to 84 days post hatching. While both forms are expressed in liver, albeit at temporally differing levels, CRP-I shows a strong association with nervous tissue while CRP-II is strongly associated to mucosal tissues of gut and skin...
May 16, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29769764/association-of-pentraxin-and-high-sensitive-c-reactive-protein-as-inflammatory-biomarkers-in-patients-with-chronic-periodontitis-and-peripheral-arterial-disease
#3
Ramanarayana Boyapati, Srikanth Chinthalapani, Arpita Ramisetti, Shyam Sunder Salavadhi, Radhika Ramachandran
Context: Inflammation is a common feature of both peripheral artery disease (PAD) and periodontal disease. Aim: The aim of this study is to evaluate the relationship between PAD and periodontal disease by examining the levels of inflammatory cytokines, pentraxin-3 (PTX-3), and high-sensitive C-reactive protein from serum. Materials and Methods: A total of 50 patients were included in this cross-sectional study. Patients were divided into two groups: those with PAD (test group) and those with the non-PAD group (control group) based on ankle-brachial index values...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29755398/deconvolution-of-human-brain-cell-type-transcriptomes-unraveled-microglia-specific-potential-biomarkers
#4
R Ayana, Shailja Singh, Soumya Pati
Microglial cells form a context-dependent network of brain immunoeffector cells. Despite their indispensable roles, unresolved questions exist around biomarker discovery relevant to their cellular localization, self-renewing potential, and brain developmental dynamics. To resolve the existent gap in the annotation of candidate biomarkers, we conducted a meta-analysis of brain cells using available high-throughput data sets for deciphering microglia-specific expression profiles. We have identified 3,290 significant genes specific to microglia and further selected the top 20 dysregulated genes on the basis of p -value and log2 FC...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29754456/pentraxin-levels-in-noneosinophilic-versus-eosinophilic-asthma
#5
Pengfei Gao, Kun Tang, Meijia Wang, Qun Yang, Yongjian Xu, Jianmiao Wang, Jianping Zhao, Jungang Xie
BACKGROUND: Innate immunity has been thought to be involved in asthma pathogenesis. Pentraxins, acting as soluble pattern recognition molecules, play an important role in humoral innate immunity. Asthma is a heterogeneous inflammatory disease of airways and can be classified as eosinophilic or noneosinophilic asthma. OBJECTIVE: To investigate whether pentraxin levels differ in subjects with eosinophilic versus noneosinophilic asthma. Furthermore, to access the predictive performance of pentraxin levels for discriminating asthma inflammatory phenotypes...
May 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29748720/aerobic-fitness-alters-the-capacity-of-mononuclear-cells-to-produce-pentraxin-3-following-maximal-exercise
#6
Aaron L Slusher, Tiffany M Zúñiga, Edmund O Acevedo
PURPOSE: Pentraxin 3 (PTX3) is a vital regulator of innate immune function. Although plasma PTX3 concentrations are elevated with aerobic fitness, the cellular functions of PTX3 remain unknown in aerobically trained and untrained subjects. METHODS: Thirty individuals (aerobically trained = 15 and untrained = 15) participated in a maximal exercise protocol to examine ex vivo PTX3 production from isolated peripheral blood mononuclear cells (PBMCs) exposed to LPS or palmitate...
May 10, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29742255/circulation-levels-of-acute-phase-proteins-pentraxin-3-and-serum-amyloid-a-in-atherosclerosis-have-correlations-with-periodontal-inflamed-surface-area
#7
Başak Temelli, Zuhal Yetkin Ay, Hasan Basri Savaş, Fatih Aksoy, Duygu Kumbul Doğuç, Ersin Uskun, Ercan Varol
Objectives One of the plausible mechanisms in the relationship between periodontitis and coronary artery disease (CAD) is the systemic inflammatory burden comprised of circulating cytokines/mediators related to periodontitis. This study aims to test the hypothesis that periodontal inflamed surface area (PISA) is correlated with higher circulating levels of acute phase reactants (APR) and pro-inflammatory cytokines/mediators and lower anti-inflammatory cytokines/mediators in CAD patients. Material and Methods Patients aged from 30 to 75 years who underwent coronary angiography with CAD suspicion were included...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29741292/microrna-150-restores-endothelial-cell-function-and-attenuates-vascular-remodeling-by-targeting-ptx3-through-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-mice-with-acute-coronary-syndrome
#8
Xian-Yuan Luo, Xiao-Qing Zhu, Ying Li, Xue-Bin Wang, Wei Yin, Yi-Shan Ge, Wei-Min Ji
MicroRNAs have been known to function as important regulators in the vascular system, with various physiopathological effects such as vascular remodeling and hypertension modulation. We aimed to explore whether microRNA-150 (miR-150) regulates endothelial cell function and vascular remodeling in acute coronary syndrome (ACS), and the involvement of PTX3 and NF-κB signaling pathway. Ten normal mice and sixty ApoE-/- mice were chosen, and their coronary artery tissues and endothelial cells were extracted. ApoE-/- mice were injected with a series of inhibitors or mimics for miR-150, or siRNA against PTX3...
May 9, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29738271/plasma-pentraxin-3-and-glucose-kinetics-to-acute-high-intensity-interval-exercise-versus-continuous-moderate-intensity-exercise-in-healthy-men
#9
Aaron L Slusher, Michael Whitehurst, Arun Maharaj, Katelyn M Dodge, Brandon G Fico, J Thomas Mock, Chun-Jung Huang
Pentraxin 3 (PTX3) is mainly synthesized and released by neutrophils to help regulate innate immunity. While plasma PTX3 concentrations are associated with improved glucose metabolism and overall metabolic health, evidence has shown that significant elevations in plasma glucose downregulates circulating levels of PTX3. To examine whether or not this relationship would be altered in response to exercise, this study investigated the kinetics of the plasma glucose and PTX3 response following high-intensity interval exercise (HIIE) and continuous moderate-intensity exercise (CMIE)...
May 8, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29736308/spocd1-promotes-the-proliferation-and-metastasis-of-glioma-cells-by-up-regulating-ptx3
#10
Quan Liu, Xiao-Yu Wang, Yuan-Yuan Qin, Xian-Lei Yan, Hong-Mou Chen, Qi-Dan Huang, Jia-Kang Chen, Jie-Min Zheng
Gliomas are the most prevalent type of primary brain tumors in adults, accounting for more than 40% of neoplasms in the central nervous system. The spen paralogue and orthologue C-terminal domain containing 1 (SPOCD1) has been recently identified and found to discriminate progressive from non-progressive bladder cancers. In this study, we detected high-level of SPOCD1 expression in glioma and its high expression significantly associated with advanced tumor grade and poor prognosis. In vitro assays showed that knockdown of SPOCD1 significantly inhibited cell proliferation and colony formation capacities in U373 and U87 cells...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29731826/expression-and-influence-of-pentraxin-3-hbalc-and-apoa1-apob-in-serum-of-patients-with-acute-myocardial-infarction-combined-with-diabetes-mellitus-type-2
#11
Yanxia Zhu, Xiaofang Wang, Weihua Wang, Hongguang Wang, Fenglei Zhang
The present study investigated the clinical significance of changes in levels of hypersensitive plasma pentraxin-3 (PTX3), hemoglobin A1c (HbAlc) and apolipoprotein A-I (ApoA1)/apolipoprotein B (ApoB) on patients with acute myocardial infarction (AMI) and diabetes mellitus type 2 (T2DM). After admission, 100 patients diagnosed with AMI combined with T2DM were selected as Group A. According to the level of fasting blood glucose (FBG), they were then subdivided into Group A1 (n=44) with FBG ≥13.0 mmol/l and Group A2 (n=56) with FBG <13...
May 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29729868/treatment-of-takayasu-arteritis-with-the-il-6r-antibody-tocilizumab-vs-cyclophosphamide
#12
Xiufang Kong, Xiaojie Zhang, Peng Lv, Xiaomeng Cui, Lili Ma, Huiyong Chen, Hao Liu, Jiang Lin, Lindi Jiang
OBJECTIVE: To evaluate the treatment effects of the IL-6R antibody tocilizumab and cyclophosphamide (CTX) in patients with Takayasu arteritis (TA) and explore the mechanism by analyzing their effects on various cytokines. METHODS AND MATERIALS: This study included 9 TA patients treated with tocilizumab, 15 TA patients treated with CTX and 24 healthy controls. Treatment effects were evaluated based on: (1) Kerr score and Indian Takayasu Clinical Activity Score (ITAS2010), (2) improvement of previous lesions and occurrence of new vascular lesions on magnetic resonance angiography (MRA), (3) changes in various cytokine levels, (4) glucocorticoid sparing, and (5) adverse effects...
May 2, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29725602/study-on-association-of-pentraxin-3-and-diabetic-nephropathy-in-a-rat-model
#13
Xuehai Chen, Jiao Luo, Minmin Wu, Zhuo Pan, Yue Xie, Hongwei Wang, Bicheng Chen, Hong Zhu
Diabetic nephropathy (DN) is a serious microvascular complication of diabetes. Compared with other therapies for diabetic patients, islet transplantation can effectively prevent and reverse diabetes-induced microvascular disease, such as diabetic retinopathy and nephropathy. PTX3 is the only long pentraxin that can be detected in renal tissue. In this study, we investigated the expression of PTX3 when early DN was reversed after islet transplantation. Methods . Diabetes was induced in rats by injecting streptozotocin (STZ)...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29715313/circulating-pentraxin-3-is-positively-associated-with-chronic-hyperglycemia-but-negatively-associated-with-plasma-aldosterone-concentration
#14
Yuichi Takashi, Minae Koga, Yoko Matsuzawa, Jun Saito, Masao Omura, Tetsuo Nishikawa
Pentraxin 3 (PTX3) is reported to be a vascular inflammation marker providing prognostic information of vasculopathy. Until today, however, the effect of aldosterone or oxidative stress on the regulation of PTX3 is unknown. In present study, we investigated to find regulative factors, especially aldosterone and oxidative stress, on PTX3. Serum PTX3 levels were measured in 75 patients (45 male and 30 women, aged 55.1±13.4 year-old (mean±SD)) with various endocrine disorders including 47 with diabetes, 24 with primary aldosteronism (PA)...
2018: PloS One
https://www.readbyqxmd.com/read/29700955/relationship-between-sodium-pentraxin-3-and-aldosterone-in-inflammation-and-cardiovascular-risk
#15
Decio Armanini, Luciana Bordin, Gabriella Donà, Raffaele Pezzani, Alessandra Andrisani, Guido Ambrosini, Chiara Sabbadin
No abstract text is available yet for this article.
April 27, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29700922/the-responses-of-the-inflammatory-marker-pentraxin-3-to-dietary-sodium-and-potassium-interventions
#16
Jia-Wen Hu, Yang Wang, Chao Chu, KeKe Wang, Yu Yan, Wenling Zheng, Qiong Ma, Jian-Jun Mu
Pentraxin-3 is a sensitive marker of inflammation that plays dual roles, pathogenic and cardioprotective, in the progression of cardiovascular diseases. Inflammation is intimately involved in salt-induced hypertension. We investigated the responses of pentraxin-3 to sodium and potassium supplementation to elucidate the potential role of pentraxin-3 in salt-induced hypertension. A total of 48 participants from northwest China were enrolled. All participants were maintained on a 3-day normal diet, which was sequentially followed by a 7-day low-sodium diet, a 7-day high-sodium diet, and a 7-day high-sodium plus potassium diet...
April 27, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29682101/evaluation-of-mediators-associated-with-the-inflammatory-response-in-prostate-cancer-patients-undergoing-radiotherapy
#17
Nice Bedini, Alessandro Cicchetti, Federica Palorini, Tiziana Magnani, Valentina Zuco, Marzia Pennati, Elisa Campi, Paola Allavena, Samantha Pesce, Sergio Villa, Barbara Avuzzi, Sara Morlino, Maria Emanuela Visentin, Nadia Zaffaroni, Tiziana Rancati, Riccardo Valdagni
A recent "hot topic" in prostate cancer radiotherapy is the observed association between acute/late rectal toxicity and the presence of abdominal surgery before radiotherapy. The exact mechanism is unclear. Our working hypothesis was that a previous surgery may influence plasma level of inflammatory molecules and this might result in enhanced radiosensitivity. We here present results on the feasibility of monitoring the expression of inflammatory molecules during radiotherapy. Plasma levels of a panel of soluble mediators associated with the inflammatory response were measured in prostate cancer patients undergoing radical radiotherapy...
2018: Disease Markers
https://www.readbyqxmd.com/read/29675428/ptx3-a-potential-biomarker-in-thyroid-associated-ophthalmopathy
#18
Pei Mou, Ziyu Chen, Lihong Jiang, Jinwei Cheng, Ruili Wei
Background: Thyroid associated ophthalmopathy (TAO) is an autoimmune disease, which involves inflammation and tissue remodeling. Pentraxin-3 (PTX3) is a component of innate immune system and recently implicated in autoimmunity. This observation may indicate that PTX3 participates in the inflammatory process of TAO. Methods: All studies were performed on TAO patients and healthy controls (45: 28 in total). RNA-seq was used to detect differential gene expression of orbital adipose-connective tissue...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29672566/exogenous-pentraxin-3-inhibits-the-reactive-oxygen-species-mitochondrial-and-apoptosis-pathway-in-acute-kidney-injury
#19
Hyung Ho Lee, Sook Young Kim, Joon Chae Na, Young Eun Yoon, Woong Kyu Han
Pentraxin-3 (PTX3) is a long-form member of the pentraxin family of proteins that has been studied in inflammatory diseases and in various organs. We found that PTX3 protects kidney cells during ischemia and proinflammatory acute kidney injury. The aim of this study was to develop an in vitro experimental model of acute kidney injury and to analyze the protective mechanism of exogenous recombinant PTX3. In this study, cells of the HK-2 renal tubular cell line were treated with a calcium ionophore (A23187), which induced injury by increasing intracellular calcium concentrations and inducing calpain activity and the generation of reactive oxygen species...
2018: PloS One
https://www.readbyqxmd.com/read/29664315/potential-correlation-between-circulating-fetuin-a-and-pentraxin-3-with-biochemical-parameters-of-calcification-in-hemodialysis-patients
#20
Javad Hashemi, Hamid-Reza Joshaghani, Arash Akaberi, Zahra Hesari, Reza Ghanbari, Mohsen Mohammadzadeh, Ali-Reza Golshan
BACKGROUND: The strong correlation between vascular calcification and cardiovascular risk, which is a major cause of mortality in hemodialysis (HD) patients, has been well established. Fetuin-A is an inhibitor of vascular calcification, and pentraxin 3 (PTX3) is produced at the site of inflammation, which is associated with cardiovascular disease (CVD). The main purpose of this study was evaluating the correlation between fetuin-A and PTX3 with some biochemical parameters effective upon vascular calcification in HD patients...
December 1, 2017: Archives of Iranian Medicine
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