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Pentraxin 3

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https://www.readbyqxmd.com/read/27893415/pentraxin-3-plasma-levels-at-graft-versus-host-disease-onset-predict-disease-severity-and-response-to-therapy-in-children-given-haematopoietic-stem-cell-transplantation
#1
Erica Dander, Paola De Lorenzo, Barbara Bottazzi, Paola Quarello, Paola Vinci, Adriana Balduzzi, Francesca Masciocchi, Sonia Bonanomi, Claudia Cappuzzello, Giulia Prunotto, Fabio Pavan, Fabio Pasqualini, Marina Sironi, Ivan Cuccovillo, Roberto Leone, Giovanni Salvatori, Matteo Parma, Elisabetta Terruzzi, Fabio Pagni, Franco Locatelli, Alberto Mantovani, Franca Fagioli, Andrea Biondi, Cecilia Garlanda, Maria Grazia Valsecchi, Attilio Rovelli, Giovanna D'Amico
Acute Graft-versus-Host Disease (GvHD) remains a major complication of allogeneic haematopoietic stem cell transplantation, with a significant proportion of patients failing to respond to first-line systemic corticosteroids. Reliable biomarkers predicting disease severity and response to treatment are warranted to improve its management. Thus, we sought to determine whether pentraxin 3 (PTX3), an acute-phase protein produced locally at the site of inflammation, could represent a novel acute GvHD biomarker. Using a murine model of the disease, we found increased PTX3 plasma levels after irradiation and at GvHD onset...
November 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27878407/low-serum-fibroblast-growth-factor-2-levels-not-accompanied-by-increased-serum-pentraxin-3-levels-in-patients-with-systemic-sclerosis
#2
Ufuk İlgen, Müçteba Enes Yayla, Nurşen Düzgün
There are scarce clinical data regarding serum pentraxin 3 (PTX3) and fibroblast growth factor 2 (FGF2) in patients with systemic sclerosis (SSc). Study was conducted to evaluate serum levels in our SSc cohort. Serum PTX3 and FGF2 concentrations were compared among SSc, disease control (systemic lupus erythematosus (SLE)), and healthy control groups. We also examined the association of serum levels of PTX3 and FGF2 with disease manifestations. Serum PTX3 levels were similarly distributed among SSc (n = 93) and healthy groups (n = 66) (p = 1...
November 22, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27864924/pentraxin-3-in-patients-with-severe-sepsis-or-shock-the-albios-trial
#3
Pietro Caironi, Serge Masson, Tommaso Mauri, Barbara Bottazzi, Roberto Leone, Michela Magnoli, Simona Barlera, Filippo Mamprin, Andrea Fedele, Alberto Mantovani, Gianni Tognoni, Antonio Pesenti, Luciano Gattinoni, Roberto Latini
BACKGROUND: The long pentraxin PTX3 is a key component of the humoral arm of innate immunity related to sepsis severity and mortality. We evaluated the clinical and prognostic significance of circulating PTX3 in the largest cohort ever reported of patients with severe sepsis or septic shock. DESIGN: Plasma PTX3 was measured on days 1, 2 and 7 after randomization of 958 patients to albumin or crystalloids for fluid resuscitation in the multicenter Albumin Italian Outcome Sepsis (ALBIOS) trial...
November 16, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27864148/three-pentraxins-c-reactive-protein-serum-amyloid-p-component-and-pentraxin-3-mediate-complement-activation-using-collectin-cl-p1
#4
Nitai Roy, Katsuki Ohtani, Yoshihiko Hidaka, Yoshiro Amano, Yasuyuki Matsuda, Kenichiro Mori, Insu Hwang, Norimitsu Inoue, Nobutaka Wakamiya
BACKGROUND: Pentraxins (PTXs) are a superfamily of multifunctional conserved proteins involved in acute-phase responses. Recently, we have shown that collectin placenta 1 (CL-P1) and C-reactive protein (CRP) mediated complement activation and failed to form terminal complement complex (TCC) in normal serum conditions because of complement factor H inhibition. METHODS: We used CL-P1 expressing CHO/ldlA7 cells to study the interaction with PTXs. Soluble type CL-P1 was used in an ELISA assay for the binding, C3 and TCC deposition experiments...
November 15, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27862647/tumor-endothelial-cells-express-high-pentraxin-3-levels
#5
Kyoko Hida, Nako Maishi, Taisuke Kawamoto, Kosuke Akiyama, Noritaka Ohga, Yasuhiro Hida, Kenji Yamada, Takayuki Hojo, Hiroshi Kikuchi, Masumi Sato, Chisaho Torii, Nobuo Shinohara, Masanobu Shindoh
It has been described that tumor progression has many similarities to inflammation and wound healing in terms of the signaling processes involved. Among biological responses, angiogenesis, which is necessary for tumor progression and metastasis, is a common hallmark; therefore, tumor blood vessels have been considered as important therapeutic targets in anticancer therapy. We focused on pentraxin 3 (PTX3), which is a marker of cancer-related inflammation, but we found no reports on its expression and function in tumor blood vessels...
December 2016: Pathology International
https://www.readbyqxmd.com/read/27859020/systemic-inflammation-in-acute-intermittent-porphyria-a-case-control-study
#6
E Storjord, J A Dahl, A Landsem, H Fure, J K Ludviksen, S Goldbeck-Wood, B O Karlsen, K S Berg, T E Mollnes, E W Nielsen, O-L Brekke
This study aimed to examine whether acute intermittent porphyria (AIP) is associated with systemic inflammation and whether the inflammation correlates with disease activity. A case-control study with 50 AIP cases and healthy age-, sex- and place of residence matched controls was performed. Plasma cytokines, insulin and C-peptide were analyzed after an overnight fast using multiplex assay. Long pentraxin-3 (PTX3) and complement activation products (C3bc and TCC) were analyzed using ELISA. Urine porphobilinogen ratio (U-PBG, µmol/mmol creatinine), hematological and biochemical tests were performed using routine methods...
November 8, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27852958/pentraxin-3-and-other-inflammatory-biomarkers-related-to-atrial-fibrillation-in-cardiac-surgery
#7
Zdenka Holubcova, Pavel Kunes, Jiri Mandak, Dana Vlaskova, Martina Kolackova, Drahomira Holmannova, Ctirad Andrys, Jan Krejsek, Tomas Holubec
OBJECTIVES: The aim was to evaluate the association between perioperative inflammatory biomarkers and atrial fibrillation (AF) in cardiac surgical patients. METHODS: Forty-two patients undergoing cardiac surgery were divided into three groups according to the occurrence of AF: Group A (n = 22) - patients with no AF, Group B (n = 11) - patients with new onset AF postoperatively and Group C (n = 9) - patients with preoperative history of atrial fibrillation. The serum levels of PTX3, CRP, TLR2, IL-8, IL-18, sFas, MMP-7 and MMP-8 were measured at the following time points: before surgery, immediately and 6 h after surgery and on the 1(st), 3(rd) and 7(th) postoperative days (POD)...
November 15, 2016: Perfusion
https://www.readbyqxmd.com/read/27849015/sterile-inflammation-as-a-factor-in-human-male-infertility-involvement-of-toll-like-receptor-2-biglycan-and-peritubular-cells
#8
C Mayer, M Adam, L Glashauser, K Dietrich, J U Schwarzer, F-M Köhn, L Strauss, H Welter, M Poutanen, A Mayerhofer
Changes in the wall of seminiferous tubules in men with impaired spermatogenesis imply sterile inflammation of the testis. We tested the hypothesis that the cells forming the wall of seminiferous tubules, human testicular peritubular cells (HTPCs), orchestrate inflammatory events and that Toll like receptors (TLRs) and danger signals from the extracellular matrix (ECM) of this wall are involved. In cultured HTPCs we detected TLRs, including TLR2. A TLR-2 ligand (PAM) augmented interleukin 6 (IL-6), monocyte chemo-attractant protein-1 (MCP-1) and pentraxin 3 (PTX3) in HTPCs...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27831642/plasma-pentraxin-3-is-associated-with-endothelial-dysfunction-in-non-alcoholic-fatty-liver-disease
#9
H Gurel, H Genc, G Celebi, E Sertoglu, A F Cicek, H Kayadibi, C N Ercin, T Dogru
OBJECTIVE: Pentraxin-3 (PTX-3) is an acute-phase protein belonging to the PTX family. It has been reported that PTX-3 is significantly associated with obesity, metabolic syndrome, and cardiovascular diseases (CVD). Non-alcoholic fatty liver disease (NAFLD) is strongly associated with atherosclerosis and CVD. In this study, we aimed to investigate the relationship of PTX-3 with circulating markers of endothelial dysfunction and atherosclerosis in patients with NAFLD. PATIENTS AND METHODS: Seventy patients with biopsy-proven NAFLD and seventy healthy controls were enrolled in the study...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27815167/calcium-independent-binding-of-human-c-reactive-protein-to-lysophosphatidylcholine-in-supported-planar-phospholipid-monolayers
#10
Tatsuro Goda, Yuji Miyahara
: Details describing the molecular dynamics of inflammation biomarker human C-reactive protein (CRP) on plasma membranes containing bioactive lipid lysophosphatidylcholine (LPC) remain elusive. Here, we measured the binding kinetics of CRP to supported phospholipid monolayers deposited on an alkanethiol self-assembled monolayer on a planar gold substrate using surface plasmon resonance. Surprisingly, CRP binding to supported 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC)/LPC monolayers was calcium-independent although CRP binding to supported POPC monolayers was calcium-dependent...
November 1, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27790798/higher-pentraxin-3-levels-are-associated-with-inflammation-in-familial-mediterranean-fever
#11
Mesudiye Bulut, Mevlut Ceri, Selman Unverdi, Mustafa Altay, Mehmet Senes, Zafer Aydın Ecemis, Murat Duranay
BACKGROUND: Circulating levels of Pentraxin-3 (PTX3) have been shown to increase in several inflammatory conditions. However, there is no information about the levels of PTX3 in patients with familial Mediterranean fever (FMF). This study was designed to evaluate the serum PTX3 levels in patients with FMF during attack and free-attack periods. METHODS: Twenty FMF patients in attack and free-attack period, and 20 age-, sex-, and body mass index-matched healthy controls were included in the study...
November 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27782323/a-journey-through-the-lectin-pathway-of-complement-mbl-and-beyond
#12
REVIEW
Peter Garred, Ninette Genster, Katrine Pilely, Rafael Bayarri-Olmos, Anne Rosbjerg, Ying Jie Ma, Mikkel-Ole Skjoedt
Mannose-binding lectin (MBL), collectin-10, collectin-11, and the ficolins (ficolin-1, ficolin-2, and ficolin-3) are soluble pattern recognition molecules in the lectin complement pathway. These proteins act as mediators of host defense and participate in maintenance of tissue homeostasis. They bind to conserved pathogen-specific structures and altered self-antigens and form complexes with the pentraxins to modulate innate immune functions. All molecules exhibit distinct expression in different tissue compartments, but all are found to a varying degree in the circulation...
November 2016: Immunological Reviews
https://www.readbyqxmd.com/read/27781062/pentraxin-3-ptx3-promoter-methylation-associated-with-ptx3-plasma-levels-and-neutrophil-to-lymphocyte-ratio-in-coronary-artery-disease
#13
Tang-Meng Guo, Li-Li Huang, Kai Liu, Li Ke, Zhi-Jian Luo, Yun-Qiao Li, Xing-Lin Chen, Bei Cheng
BACKGROUND: Pentraxin 3 (PTX3) is expressed in the heart under inflammatory conditions and plays an important role in atherogenesis. Patients with increased PTX3 levels may suffer from higher rates of cardiac events. Regulation of specific genes by promoter methylation is important in atherogenesis. The factors influencing PTX3 levels and the association between epigenetics and PTX3 levels have not been investigated. METHODS: Blood samples were collected from 64 patients admitted to the Department of Cardiology, 35 who had coronary artery disease (CAD), and 29 who were CAD-free...
August 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27779166/association-of-plasma-pentraxin-3-levels-on-admission-with-in-hospital-mortality-in-patients-with-acute-type-a-aortic-dissection
#14
Qin Zhou, Xiang-Ping Chai, Zhen-Fei Fang, Xin-Qun Hu, Liang Tang
BACKGROUND: Acute aortic dissection is a life-threatening cardiovascular emergency. Pentraxin-3 (PTX3) is proposed as a prognostic marker and found to be related to worse clinical outcomes in various cardiovascular diseases. This study sought to investigate the association of circulating PTX3 levels with in-hospital mortality in patients with acute Type A aortic dissection (TAAD). METHODS: A total of 98 patients with TAAD between January 2012 and December 2015 were enrolled in this study...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27778191/impact-of-adding-eicosapentaenoic-acid-to-statin-therapy-on-plasma-pentraxin-3-level-in-patients-with-stable-coronary-artery-disease-a-6-month-randomized-controlled-study
#15
Shigemasa Tani, Ken Nagao, Tsukasa Yagi, Wataru Atsumi, Atsushi Hirayama
BACKGROUND: We hypothesized that the additional administration of eicosapentaenoic acid (EPA) in patients with stable coronary artery disease (CAD) receiving statin has the potential to lower the serum pentraxin 3 (PTX3) level, an indicator of plaque stabilization. METHODS: We randomly assigned CAD patients already receiving statin therapy to an EPA group (1800 mg/day, n = 53) or control group (n = 53). RESULTS: No significant difference was found in the change in the plasma PTX3 level between the groups...
October 24, 2016: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/27750169/arsenic-and-fluoride-induce-apoptosis-inflammation-and-oxidative-stress-in-cultured-human-umbilical-vein-endothelial-cells
#16
Yanqin Ma, Zhenhua Ma, Shuqin Yin, Xiaoyan Yan, Jundong Wang
Excessive amount of inorganic arsenic (iAs) and fluoride (F) coexist in drinking water in many regions, which is associated with high risk of vascular diseases. However, the underlying mechanisms are not well studied. The present study was to evaluate the effects of iAs and F individual or combined exposure on endothelial activation and apoptosis in vitro. Primary human umbilical vein endothelial cells (HUVECs) were exposed to 5 μM As2O3 and/or 1 mM NaF. Changes in endothelial cell apoptosis, inflammation, oxidative stress and nitric oxide (NO) production were analyzed...
October 14, 2016: Chemosphere
https://www.readbyqxmd.com/read/27749762/infectious-complications-and-immune-inflammatory-response-in-cardiogenic-shock-patients-a-prospective-observational-study
#17
Jiri Parenica, Jiri Jarkovsky, Jan Malaska, Alexandre Mebazaa, Jana Gottwaldova, Katerina Helanova, Jiri Litzman, Milan Dastych, Josef Tomandl, Jindrich Spinar, Ludmila Dostalova, Petr Lokaj, Marie Tomandlova, Monika Goldergova Pavkova, Pavel Sevcik, Matthieu Legrand
INTRODUCTION: Cardiogenic shock (CS) patients are at a high risk of developing infectious complications; however, their early detection is difficult, mainly due to a frequently occurring non-infectious inflammatory response, which accompanies an extensive myocardial infarction or a post-cardiac arrest syndrome. The goal of our prospective study was to describe infectious complications in CS and the immune/inflammatory response based on a serial measurement of several blood-based inflammatory biomarkers...
September 29, 2016: Shock
https://www.readbyqxmd.com/read/27734498/association-of-peripheral-arterial-disease-with-periodontal-disease-analysis-of-inflammatory-cytokines-and-an-acute-phase-protein-in-gingival-crevicular-fluid-and-serum
#18
M Unlu Çalapkorur, B A Alkan, Z Tasdemir, Y Akcali, E Saatçi
BACKGROUND AND OBJECTIVE: Inflammation is a common feature of both peripheral arterial disease (PAD) and periodontal disease. The aim of this study was to evaluate the relationship between PAD and periodontal disease by examining the levels of inflammatory cytokines (pentraxin 3 and interleukin 1β) and high sensitive C-reactive protein from gingival crevicular fluid and serum. MATERIAL AND METHODS: A total of 60 patients were included in this cross-sectional study...
October 13, 2016: Journal of Periodontal Research
https://www.readbyqxmd.com/read/27720037/inflammatory-f2-isoprostane-prostaglandin-f2%C3%AE-pentraxin-3-levels-and-breast-cancer-risk-the-swedish-mammography-cohort
#19
Samar Basu, Holly Harris, Alicja Wolk, Adrien Rossary, Florence Caldefie-Chézet, Marie-Paule Vasson, Anders Larsson
INTRODUCTION: Breast cancer is a common cancer among women. Identifying cellular participation of F2-isoprostane, prostaglandin F2α (PGF2α) and pentraxin 3 (PTX3) in cancer we evaluated whether their prediagnostic systemic levels that originate from different inflammatory pathways were associated with breast cancer risk. METHODS: Seventy-eight breast cancer cases diagnosed after blood collection and 797 controls from the Swedish Mammography Cohort were analysed for urinary F2-isoprostane, PGF2α and plasma PTX3 levels...
October 2016: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/27659908/pentraxin-3-recruits-complement-factor-h-to-protect-against-oxidative-stress-induced-complement-and-inflammasome-overactivation
#20
Lei Wang, Marisol Cano, Sayantan Datta, Hong Wei, Katayoon B Ebrahimi, Yara Gorashi, Cecilia Garlanda, James T Handa
The discovery that genetic abnormalities in complement factor H (FH) are associated with an increased risk for age-related macular degeneration (AMD), the most common cause of blindness among the elderly, raised hope of new treatments for this vision-threatening disease. Nonetheless, over a decade after the identification of this important association, how innate immunity contributes to AMD remains unresolved. Pentraxin 3 (PTX3), an essential component of the innate immunity system that plays a non-redundant role in controlling inflammation, regulates complement by interacting with complement components...
December 2016: Journal of Pathology
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