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https://www.readbyqxmd.com/read/28725942/l-arginine-supplementation-prevents-allodynia-and-hyperalgesia-in-painful-diabetic-neuropathic-rats-by-normalizing-plasma-nitric-oxide-concentration-and-increasing-plasma-agmatine-concentration
#1
Lusliany J Rondón, M C Farges, N Davin, B Sion, A M Privat, M P Vasson, A Eschalier, C Courteix
PURPOSE: Neuropathic pain is a common diabetic complication. It is characterized by symptoms of spontaneous and stimulus-evoked pain including hyperalgesia and allodynia. L-Arginine is a common precursor of many metabolites of biological interest, in particular, nitric oxide (NO), ornithine, and hence polyamines. In central nervous system, NO, glutamate, and polyamines share an N-methyl-D-aspartate (NMDA) receptor-mediated effect. We hypothesized that a variation in arginine metabolism caused by diabetes may contribute to development and maintenance of neuropathic pain and to the worsening of clinical and biological signs of diabetes...
July 19, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28722259/l-ornithine-and-l-lysine-stimulate-gastrointestinal-motility-via-transient-receptor-potential-vanilloid-1
#2
Junya Nakato, Yee Yin Ho, Ryo Omae, Takafumi Mizushige, Kunitoshi Uchida, Makoto Tominaga, Minji Kim, Tsuyoshi Goto, Nobuyuki Takahashi, Teruo Kawada, Saori Akiduki, Ryuhei Kanamoto, Kousaku Ohinata
SCOPE: The gastrointestinal (GI) tract senses and responds to intraluminal nutrients and these interactions often affect GI functions. We found that, among basic amino acids, L-ornithine (Orn) and L-lysine (Lys) stimulated but L-arginine (Arg) suppressed GI motility after oral administration (24 mmol/kg) in mice (Orn and Lys, 14.3 and 26.4% promotion; Arg, 7.7% suppression). We investigated the mechanism of the action of Orn and Lys on GI motility. METHODS AND RESULTS: Orn-induced promotion of small intestinal transit was significantly inhibited (P<0...
July 18, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28720279/metabolomic-analysis-identifies-altered-metabolic-pathways-in-multiple-sclerosis
#3
Simone Poddighe, Federica Murgia, Lorena Lorefice, Sonia Liggi, Eleonora Cocco, Maria Giovanna Marrosu, Luigi Atzori
Multiple sclerosis (MS) is a chronic, demyelinating disease that affects the central nervous system and is characterized by a complex pathogenesis and difficult management. The identification of new biomarkers would be clinically useful for more accurate diagnoses and disease monitoring. Metabolomics, the identification of small endogenous molecules in, offers an instantaneous molecular snapshot of the MS phenotype. Here the metabolomic profiles (utilizing plasma from patients with MS) were characterized with a Gas cromatography-mass spectrometry-based platform followed by a multivariate statistical analysis and comparison with a healthy control (HC) population...
July 15, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28716421/dual-functioning-of-plant-arginases-provides-a-third-route-for-putrescine-synthesis
#4
Jigar Patel, Menaka Ariyaratne, Sheaza Ahmed, Lingxiao Ge, Vipaporn Phuntumart, Andrea Kalinoski, Paul F Morris
Two biosynthetic routes are known for putrescine, an essential plant metabolite. Ornithine decarboxylase (ODC) converts ornithine directly to putrescine, while a second route for putrescine biosynthesis utilizes arginine decarboxylase (ADC) to convert arginine to agmatine, and two additional enzymes, agmatine iminohydrolase (AIH) and N-carbamoyl putrescine aminohydrolase (NLP1) to complete this pathway. Here we show that plants can use ADC and arginase/agmatinase (ARGAH) as a third route for putrescine synthesis...
September 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28715750/polyamines-may-influence-phytochelatin-synthesis-during-cd-stress-in-rice
#5
Magda Pál, Gabriella Csávás, Gabriella Szalai, Tímea Oláh, Radwan Khalil, Rusina Yordanova, Gyöngyvér Gell, Zsófia Birinyi, Edit Németh, Tibor Janda
Although the metabolism of phytochelatins and higher polyamines are linked with each other, the direct relationship between them under heavy metal stress has not yet been clarified. Two approaches were used to reveal the influence of polyamine content on cadmium stress responses, particularly with regard to phytochelatin synthesis: putrescine pre-treatment of rice plants followed by cadmium stress, and treatment with the putrescine synthesis inhibitor, 2-(difluoromethyl)ornithine combined with cadmium treatment...
July 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28712602/anaplerotic-therapy-in-propionic-acidemia
#6
Nicola Longo, Leisa B Price, Eduard Gappmaier, Nancy L Cantor, Sharon L Ernst, Carrie Bailey, Marzia Pasquali
BACKGROUND: Propionic acidemia is a rare metabolic disorder caused by a deficiency of propionyl- CoA carboxylase, the enzyme converting propionyl-CoA to methylmalonyl-CoA that subsequently enters the citric acid cycle as succinyl-CoA. Patients with propionic acidemia cannot metabolize propionic acid, which combines with oxaloacetate to form methylcitric acid. This, with the defective supply of succinyl-CoA, may lead to a deficiency in citric acid cycle intermediates. PURPOSE: The objective of this study was to determine whether supplements with glutamine (400mg/kg per day), citrate (7...
July 12, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28708224/carbonic-anhydrase-inhibitor-with-topical-nsaid-therapy-to-manage-cystoid-macular-edema-in-a-case-of-gyrate-atrophy
#7
Elena Piozzi, Salvatore Alessi, Silvia Santambrogio, Giovanni Cillino, Marco Mazza, Aissa Iggui, Salvatore Cillino
PURPOSE: Gyrate atrophy of the choroid and retina (GACR) is a rare chorioretinal dystrophy characterized by a deficiency of the enzyme ornithine aminotransferase, inherited in an autosomal recessive pattern. CASE REPORT: We report a case of a 17-year-old girl with GACR, for whom the level of serum ornithine had been reduced by an arginine-restricted diet. The patient was responsive to an association of topical nonsteroidal anti-inflammatory drugs (NSAIDs) and a carbonic anhydrase inhibitor (CAI) to reduce cystoid macular edema (CME)...
July 8, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/28707668/-low-molecular-weight-regulators-of-biogenic-polyamine-metabolism-affect-cytokine-production-and-expression-of-hepatitis-%C3%B0-virus-proteins-in-huh7-5-human-hepatocarcinoma-cells
#8
O V Masalova, E I Lesnova, E I Samokhvalov, K Yu Permyakova, A V Ivanov, S N Kochetkov, A A Kushch
Hepatitis C virus (HCV) induces the expression of the genes of proinflammatory cytokines, the excessive production of which may cause cell death, and contribute to development of liver fibrosis and hepatocarcinoma. The relationship between cytokine production and metabolic disorders in HCV-infected cells remains obscure. The levels of biogenic polyamines, spermine, spermidine, and their precursor putrescine, may be a potential regulator of these processes. The purpose of the present work was to study the effects of the compounds which modulate biogenic polyamines metabolism on cytokine production and HCV proteins expression...
May 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/28706468/retinal-metabolic-events-in-preconditioning-light-stress-as-revealed-by-wide-spectrum-targeted-metabolomics
#9
Juan Manuel Chao de la Barca, Nuan-Ting Huang, Haihan Jiao, Lydie Tessier, Cédric Gadras, Gilles Simard, Riccardo Natoli, Guillaume Tcherkez, Pascal Reynier, Krisztina Valter
INTRODUCTION: Light is the primary stimulus for vision, but may also cause damage to the retina. Pre-exposing the retina to sub-lethal amount of light (or preconditioning) improves chances for retinal cells to survive acute damaging light stress. OBJECTIVES: This study aims at exploring the changes in retinal metabolome after mild light stress and identifying mechanisms that may be involved in preconditioning. METHODS: Retinas from 12 rats exposed to mild light stress (1000 lux × for 12 h) and 12 controls were collected one and seven days after light stress (LS)...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28704931/alterations-in-circulating-amino-acid-metabolite-ratio-associated-with-arginase-activity-are-potential-indicators-of-metabolic-syndrome-the-korean-genome-and-epidemiology-study
#10
Jiyoung Moon, Oh Yoen Kim, Garam Jo, Min-Jeong Shin
Upregulated arginase activity, which competes with nitric oxide synthase (NOS), impairs nitric oxide production and has been implicated in various metabolic disorders. This study examined whether circulating amino acid metabolite ratios are associated with arginase and NOS activities and whether arginine bioavailability is associated with metabolic syndrome (MetS). Data related to arginase and NOS activities were collected from non-diabetic Koreans without cardiovascular disease (n = 1998) in the Ansan-Ansung cohorts (2005-2006)...
July 12, 2017: Nutrients
https://www.readbyqxmd.com/read/28695314/bacterial-production-and-reconstitution-in-proteoliposomes-of-solanum-lycopersicum-cat2-a-transporter-of-basic-amino-acids-and-organic-cations
#11
Teresa Maria Rosaria Regina, Michele Galluccio, Mariafrancesca Scalise, Lorena Pochini, Cesare Indiveri
The vacuolar SlCAT2 was cloned, over-produced in E. coli and reconstituted in proteoliposomes. Arg, Ornithine and Lys were identified as substrates. Unexpectedly, also the organic cations Tetraethylammonium and Acetylcholine were transported indicating involvement of SlCAT2 in signaling. In land plants several transporters are involved in ion and metabolite flux across membranes of cells or intracellular organelles. The vacuolar amino acid transporter CAT2 from Solanum lycopersicum was investigated in this work...
July 10, 2017: Plant Molecular Biology
https://www.readbyqxmd.com/read/28694661/relevance-of-proteolysis-and-proteasome-activation-in-fatty-liver-graft-preservation-an-institut-georges-lopez-1-vs-university-of-wisconsin-appraisal
#12
Mohamed Amine Zaouali, Arnau Panisello-Roselló, Alexandre Lopez, Carlos Castro Benítez, Emma Folch-Puy, Agustín García-Gil, Teresa Carbonell, René Adam, Joan Roselló-Catafau
AIM: To compare liver proteolysis and proteasome activation in steatotic liver grafts conserved in University of Wisconsin (UW) and Institut Georges Lopez-1 (IGL-1) solutions. METHODS: Fatty liver grafts from male obese Zücker rats were conserved in UW and IGL-1 solutions for 24 h at 4 °Cand subjected to "ex vivo" normo-thermic perfusion (2 h; 37 °C). Liver proteolysis in tissue specimens and perfusate was measured by reverse-phase high performance liquid chromatography...
June 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28683962/arginine-nitric-oxide-metabolites-and-cardiac-dysfunction-in-patients-with-breast-cancer
#13
Brian S Finkelman, Mary Putt, Teresa Wang, Le Wang, Hari Narayan, Susan Domchek, Angela DeMichele, Kevin Fox, Jennifer Matro, Payal Shah, Amy Clark, Angela Bradbury, Vivek Narayan, Joseph R Carver, W H Wilson Tang, Bonnie Ky
BACKGROUND: Oxidative/nitrosative stress and endothelial dysfunction are hypothesized to be central to cancer therapeutics-related cardiac dysfunction (CTRCD). However, the relationship between circulating arginine-nitric oxide (NO) metabolites and CTRCD remains unstudied. OBJECTIVES: This study sought to examine the relationship between arginine-NO metabolites and CTRCD in a prospective cohort of 170 breast cancer patients treated with doxorubicin with or without trastuzumab...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28679749/adaptation-of-bacillus-subtilis-to-life-at-extreme-potassium-limitation
#14
Jan Gundlach, Christina Herzberg, Dietrich Hertel, Andrea Thürmer, Rolf Daniel, Hannes Link, Jörg Stülke
Potassium is the most abundant metal ion in every living cell. This ion is essential due to its requirement for the activity of the ribosome and many enzymes but also because of its role in buffering the negative charge of nucleic acids. As the external concentrations of potassium are usually low, efficient uptake and intracellular enrichment of the ion is necessary. The Gram-positive bacterium Bacillus subtilis possesses three transporters for potassium, KtrAB, KtrCD, and the recently discovered KimA. In the absence of the high-affinity transporters KtrAB and KimA, the bacteria were unable to grow at low potassium concentrations...
July 5, 2017: MBio
https://www.readbyqxmd.com/read/28679527/ornithine-uptake-and-the-modulation-of-drug-sensitivity-in-trypanosoma-brucei
#15
Juan P Macedo, Rachel B Currier, Corina Wirdnam, David Horn, Sam Alsford, Doris Rentsch
Trypanosoma brucei, protozoan parasites that cause human African trypanosomiasis (HAT), depend on ornithine uptake and metabolism by ornithine decarboxylase (ODC) for survival. Indeed, ODC is the target of the WHO "essential medicine" eflornithine, which is antagonistic to another anti-HAT drug, suramin. Thus, ornithine uptake has important consequences in T. brucei, but the transporters have not been identified. We describe these amino acid transporters (AATs). In a heterologous expression system, TbAAT10-1 is selective for ornithine, whereas TbAAT2-4 transports both ornithine and histidine...
July 5, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28668485/edwardsiella-piscicida-lacking-the-cyclic-amp-receptor-protein-crp-is-avirulent-and-immunogenic-in-fish
#16
Yunjeong Choe, Junmo Park, Jong Earn Yu, Jeong-Il Oh, Suhkmann Kim, Ho Young Kang
Edwardsiella piscicida is a Gram-negative pathogen that generally causes lethal septicemia in marine and freshwater fish. We generated a E. piscicida CK216 Δcrp mutant to investigate various biological roles related to this organism, including pathogenesis. Lack of Crp in CK216 was demonstrated by immunoblotting using a Crp-specific antibody. Compared to the parental strain, the mutant exhibited changes in three biochemical phenotypes, including ornithine decarboxylation, citrate utilization, and H2S production...
June 28, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28659245/newborn-screening-for-hyperargininemia-due-to-arginase-1-deficiency
#17
Bradford L Therrell, Robert Currier, David Lapidus, Meredith Grimm, Stephen D Cederbaum
Hyperargininemia caused by Arginase 1 deficiency is a rare disorder of the urea cycle that can be diagnosed by elevation of arginine in newborn screening blood spots when analyzed by tandem mass spectrometry. Hyperargininemia is currently included as a secondary target on the U.S. Recommended Uniform Screening Panel, which directly influences state-based newborn screening. Because of the apparent low disease frequency and lack of case detection and treatment data, detailed attention has not been given to a model newborn screening algorithm including appropriate analytical cutoff values for disease indicators...
June 20, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28658303/critical-role-of-sik3-in-mediating-high-salt-and-il-17-synergy-leading-to-breast-cancer-cell-proliferation
#18
Suneetha Amara, Ciera Majors, Bipradas Roy, Salisha Hill, Kristie L Rose, Elbert L Myles, Venkataswarup Tiriveedhi
Chronic inflammation is a well-known precursor for cancer development and proliferation. We have recently demonstrated that high salt (NaCl) synergizes with sub-effective interleukin (IL)-17 to induce breast cancer cell proliferation. However, the exact molecular mechanisms mediating this effect are unclear. In our current study, we adopted a phosphoproteomic-based approach to identify salt modulated kinase-proteome specific molecular targets. The phosphoprotemics based binary comparison between heavy labelled MCF-7 cells treated with high salt (Δ0...
2017: PloS One
https://www.readbyqxmd.com/read/28648058/effect-of-exogenous-nitro-oxide-on-chilling-tolerance-polyamine-proline-and-%C3%AE-aminobutyric-acid-in-bamboo-shoots-phyllostachys-praecox-f-prevernalis
#19
Di Wang, Li Li, Yanqun Xu, Jarukitt Limwachiranon, Dong Li, Zhaojun Ban, Zisheng Luo
The effects of exogenous nitro oxide (NO) on chilling resistance and the metabolism of polyamine, proline, and γ-aminobutyric acid of bamboo shoots were investigated. Bamboo shoots were dipped in 0.07 mM sodium nitroprusside (SNP) and stored at 1 °C for 56 days. During the storage, the development of chilling injury of SNP treated bamboo shoots was inhibited with decreased accumulation of malonaldehyde and electrical leakage. At the end of storage, the chilling injury incidence of treated bamboo shoots decreased by 37...
July 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28644989/transcriptome-analysis-shows-activation-of-the-arginine-deiminase-pathway-in-lactococcus-lactis-as-a-response-to-ethanol-stress
#20
Lorena Díez, Ana Solopova, Rocío Fernández-Pérez, Miriam González, Carmen Tenorio, Oscar P Kuipers, Fernanda Ruiz-Larrea
This paper describes the molecular response of Lactococcus lactis NZ9700 to ethanol. This strain is a well-known nisin producer and a lactic acid bacteria (LAB) model strain. Global transcriptome profiling using DNA microarrays demonstrated a bacterial adaptive response to the presence of 2% ethanol in the culture broth and differential expression of 67 genes. The highest up-regulation was detected for those genes involved in arginine degradation through the arginine deiminase (ADI) pathway (20-40 fold up-regulation)...
May 24, 2017: International Journal of Food Microbiology
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