keyword
MENU ▼
Read by QxMD icon Read
search

RNS60

keyword
https://www.readbyqxmd.com/read/29188424/increase-in-mitochondrial-biogenesis-in-neuronal-cells-by-rns60-a-physically-modified-saline-via-phosphatidylinositol-3-kinase-mediated-upregulation-of-pgc1%C3%AE
#1
Goutam Chandra, Madhuchhanda Kundu, Suresh B Rangasamy, Sridevi Dasarathy, Supurna Ghosh, Richard Watson, Kalipada Pahan
This study highlights a novel approach to upregulate mitochondrial biogenesis in neuronal cells. RNS60 is a 0.9% saline solution containing oxygenated nanobubbles that is generated by subjecting normal saline to Taylor-Couette-Poiseuille (TCP) flow under elevated oxygen pressure. RNS60, but not NS (normal saline), PNS60 (saline containing a comparable level of oxygen without the TCP modification), or RNS10.3 (TCP-modified normal saline without excess oxygen), increased the expression of Nrf1, Tfam, Mcu, and Tom20 (genes associated with mitochondrial biogenesis) and upregulated mitochondrial biogenesis in MN9D dopaminergic neuronal cells...
November 29, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29143164/upregulation-of-myelin-gene-expression-by-a-physically-modified-saline-via-phosphatidylinositol-3-kinase-mediated-activation-of-creb-implications-for-multiple-sclerosis
#2
Malabendu Jana, Supurna Ghosh, Kalipada Pahan
An increase in central nervous system (CNS) remyelination and a decrease in CNS inflammation are important steps to halt the progression of multiple sclerosis (MS). RNS60 is a bioactive aqueous solution generated by subjecting normal saline to Taylor-Couette-Poiseuille flow under elevated oxygen pressure. Recently we have demonstrated that RNS60 exhibits anti-inflammatory properties. Here, we describe promyelinating property of RNS60. RNS60, but not normal saline (NS), RNS10.3 (TCP-modified saline without excess oxygen) or PNS60 (saline containing excess oxygen without TCP modification), stimulated the expression of myelin-specific genes and proteins (myelin basic protein, MBP; myelin oligodendrocyte glycoprotein, MOG and proteolipid protein, PLP) in primary mouse oligodendroglia and mixed glial cells...
November 15, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28271325/nebulization-of-rns60-a-physically-modified-saline-attenuates-the-adoptive-transfer-of-experimental-allergic-encephalomyelitis-in-mice-implications-for-multiple-sclerosis-therapy
#3
Susanta Mondal, Suresh B Rangasamy, Supurna Ghosh, Richard L Watson, Kalipada Pahan
Developing a new and effective therapeutic approach against multiple sclerosis (MS) is always an important area of research. RNS60 is a bioactive aqueous solution generated by subjecting normal saline to Taylor-Couette-Poiseuille flow under elevated oxygen pressure. Recently we have demonstrated that RNS60, administered through intraperitoneal injection, ameliorated clinical symptoms and disease progression of experimental allergic encephalomyelitis (EAE), an animal model of MS. Since the intravenous route is not preferred for treating a chronic condition, we tested if nebulization of RNS60 could attenuate the disease process of adoptively-transferred EAE in mice...
May 2017: Neurochemical Research
https://www.readbyqxmd.com/read/27451946/potential-benefit-of-the-charge-stabilized-nanostructure-saline-rns60-for-myelin-maintenance-and-repair
#4
Vijayaraghava T S Rao, Damla Khan, Russell G Jones, Diane S Nakamura, Timothy E Kennedy, Qiao-Ling Cui, Malena B Rone, Luke M Healy, Richard Watson, Supurna Ghosh, Jack P Antel
Myelin injury in multiple sclerosis (MS) has been attributed both to "outside-in" primary immune mediated and "inside-out" metabolic stress of oligodendrocyte (OL) related mechanisms. Subsequent remyelination is dependent on recruitment and differentiation of oligodendrocyte progenitor cells (OPCs). RNS60 is a physically-modified saline containing charge-stabilized nanobubbles generated by subjecting normal saline to Taylor-Couette-Poiseuille (TCP) flow under elevated oxygen pressure. Administration of RNS60 has been shown to reduce the severity of EAE by dampening the immune response and myelin loss...
2016: Scientific Reports
https://www.readbyqxmd.com/read/25742953/rns60-a-charge-stabilized-nanostructure-saline-alters-xenopus-laevis-oocyte-biophysical-membrane-properties-by-enhancing-mitochondrial-atp-production
#5
Soonwook Choi, Eunah Yu, Duk-Soo Kim, Mutsuyuki Sugimori, Rodolfo R Llinás
We have examined the effects of RNS60, a 0.9% saline containing charge-stabilized oxygen nanobubble-based structures. RNS60 is generated by subjecting normal saline to Taylor-Couette-Poiseuille (TCP) flow under elevated oxygen pressure. This study, implemented in Xenopus laevis oocytes, addresses both the electrophysiological membrane properties and parallel biological processes in the cytoplasm. Intracellular recordings from defolliculated X. laevis oocytes were implemented in: (1) air oxygenated standard Ringer's solution, (2) RNS60-based Ringer's solution, (3) RNS10...
March 2015: Physiological Reports
https://www.readbyqxmd.com/read/25089827/a-physically-modified-saline-suppresses-neuronal-apoptosis-attenuates-tau-phosphorylation-and-protects-memory-in-an-animal-model-of-alzheimer-s-disease
#6
Khushbu K Modi, Arundhati Jana, Supurna Ghosh, Richard Watson, Kalipada Pahan
Alzheimer's disease (AD), the leading cause of dementia in the aging population, is characterized by the presence of neuritic plaques, neurofibrillary tangles and extensive neuronal apoptosis. Neuritic plaques are mainly composed of aggregates of amyloid-β (Aβ) protein while neurofibrillary tangles are composed of the hyperphosphorylated tau protein. Despite intense investigations, no effective therapy is currently available to halt the progression of this disease. Here, we have undertaken a novel approach to attenuate apoptosis and tau phosphorylation in cultured neuronal cells and in a transgenic animal model of AD...
2014: PloS One
https://www.readbyqxmd.com/read/25007337/enhancement-of-morphological-plasticity-in-hippocampal-neurons-by-a-physically-modified-saline-via-phosphatidylinositol-3-kinase
#7
Avik Roy, Khushbu K Modi, Saurabh Khasnavis, Supurna Ghosh, Richard Watson, Kalipada Pahan
Increase of the density of dendritic spines and enhancement of synaptic transmission through ionotropic glutamate receptors are important events, leading to synaptic plasticity and eventually hippocampus-dependent spatial learning and memory formation. Here we have undertaken an innovative approach to upregulate hippocampal plasticity. RNS60 is a 0.9% saline solution containing charge-stabilized nanobubbles that are generated by subjecting normal saline to Taylor-Couette-Poiseuille (TCP) flow under elevated oxygen pressure...
2014: PloS One
https://www.readbyqxmd.com/read/24575037/enhanced-synaptic-transmission-at-the-squid-giant-synapse-by-artificial-seawater-based-on-physically-modified-saline
#8
Soonwook Choi, Eunah Yu, Guilherme Rabello, Suelen Merlo, Ajmal Zemmar, Kerry D Walton, Herman Moreno, Jorge E Moreira, Mutsuyuki Sugimori, Rodolfo R Llinás
Superfusion of the squid giant synapse with artificial seawater (ASW) based on isotonic saline containing oxygen nanobubbles (RNS60 ASW) generates an enhancement of synaptic transmission. This was determined by examining the postsynaptic response to single and repetitive presynaptic spike activation, spontaneous transmitter release, and presynaptic voltage clamp studies. In the presence of RNS60 ASW single presynaptic stimulation elicited larger postsynaptic potentials (PSP) and more robust recovery from high frequency stimulation than in control ASW...
2014: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/24122363/protection-of-dopaminergic-neurons-in-a-mouse-model-of-parkinson-s-disease-by-a-physically-modified-saline-containing-charge-stabilized-nanobubbles
#9
Saurabh Khasnavis, Avik Roy, Supurna Ghosh, Richard Watson, Kalipada Pahan
Neuroinflammation underlies the pathogenesis of various neurodegenerative disorders including Parkinson's disease (PD). Despite intense investigations, no effective therapy is available to stop its onset or halt its progression. RNS60 is a novel therapeutic containing charge-stabilized nanobubbles in saline, generated by subjecting normal saline to Taylor-Couette-Poiseuille flow under elevated oxygen pressure. Recently, we have delineated that RNS60 inhibits the expression of proinflammatory molecules in glial cells via type 1A phosphatidylinositol-3 kinase (PI3K)-mediated upregulation of IκBα...
March 2014: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/23284794/protection-of-tregs-suppression-of-th1-and-th17-cells-and-amelioration-of-experimental-allergic-encephalomyelitis-by-a-physically-modified-saline
#10
Susanta Mondal, Jeffrey A Martinson, Supurna Ghosh, Richard Watson, Kalipada Pahan
In multiple sclerosis (MS) and other autoimmune diseases, the autoreactive T cells overcome the resistance provided by the regulatory T cells (Tregs) due to a decrease in the number of Foxp3-expressing Tregs. Therefore, upregulation and/or maintenance of Tregs during an autoimmune insult may have therapeutic efficacy in autoimmune diseases. Although several immunomodulatory drugs and molecules are available, most present significant side effects over long-term use. Here we have undertaken an innovative approach to upregulate Tregs and achieve immunomodulation...
2012: PloS One
https://www.readbyqxmd.com/read/22753407/suppression-of-nuclear-factor-%C3%AE%C2%BAb-activation-and-inflammation-in-microglia-by-physically-modified-saline
#11
Saurabh Khasnavis, Arundhati Jana, Avik Roy, Monalisa Mazumder, Bharat Bhushan, Tony Wood, Supurna Ghosh, Richard Watson, Kalipada Pahan
Chronic inflammation involving activated microglia and astroglia is becoming a hallmark of many human diseases, including neurodegenerative disorders. Although NF-κB is a multifunctional transcription factor, it is an important target for controlling inflammation as the transcription of many proinflammatory molecules depends on the activation of NF-κB. Here, we have undertaken a novel approach to attenuate NF-κB activation and associated inflammation in activated glial cells. RNS60 is a 0.9% saline solution containing charge-stabilized nanostructures that are generated by subjecting normal saline to Taylor-Couette-Poiseuille (TCP) flow under elevated oxygen pressure...
August 24, 2012: Journal of Biological Chemistry
1
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"