keyword
https://read.qxmd.com/read/38529299/effect-of-anti-inflammatory-treatments-on-patient-outcomes-and-concentrations-of-inflammatory-modulators-in-the-post-surgical-and-post-traumatic-tibiofemoral-joint-setting-a-narrative-review
#21
REVIEW
Conner P Olson, Mitchell I Kennedy, Nicholas N DePhillipo, Adam J Tagliero, Robert F LaPrade, Nicholas I Kennedy
BACKGROUND AND OBJECTIVE: There are several anti-inflammatory therapeutic options that can be used in the context of post-surgical and post-traumatic knee settings. Each of these options carries with it certain benefits, as well as potential issues depending on the duration and administration of each therapy. An understanding of how these anti-inflammatory drugs modulate various biomarkers of inflammation is also necessary in understanding how they can affect patient and objective outcomes following acute knee injury or surgery...
2024: Annals of joint
https://read.qxmd.com/read/38529297/the-effect-of-nonsteroidal-anti-inflammatory-drug-use-on-soft-tissue-and-bone-healing-in-the-knee-a-systematic-review
#22
REVIEW
Rafat H Solaiman, Jack Dirnberger, Nicholas I Kennedy, Nicholas N DePhillipo, Adam J Tagliero, Konrad Malinowski, Sigbjorn Dimmen, Robert F LaPrade
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to mitigate pain and inflammation associated with musculoskeletal conditions; however, there is conflicting data on the adverse effects of these drugs on tissue and bone healing. The objective of this study was to investigate the effect of NSAIDs on the healing of knee, soft tissue, and bone. METHODS: A systematic literature search was conducted across PubMed/MEDLINE, Excerpta Medical Database (Embase)/Ovid, and the Cochrane Central Register of Controlled Trials databases...
2024: Annals of joint
https://read.qxmd.com/read/38529191/antibacterial-activity-of-cinnamon-essential-oil-and-its-main-component-of-cinnamaldehyde-and-the-underlying-mechanism
#23
JOURNAL ARTICLE
Chengjie Shu, Ling Ge, Zhuohang Li, Bin Chen, Shengliang Liao, Lu Lu, Qinlin Wu, Xinyi Jiang, Yuhan An, Zongde Wang, Man Qu
Background: Plant essential oils have long been regarded as repositories of antimicrobial agents. In recent years, they have emerged as potential alternatives or supplements to antimicrobial drugs. Although literature reviews and previous studies have indicated that cinnamon essential oil (CIEO) and its major component, cinnamaldehyde (CID), possess potent antibacterial activities, their antibacterial mechanisms, especially the in vivo antibacterial mechanisms, remain elusive. Methods: In this study, we utilized the in vivo assessment system of Caenorhabditis elegans ( C...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38529017/tizanidine-advances-in-pharmacology-therapeutics-and-drug-formulations
#24
REVIEW
Ling-Ling Zhu, Yan-Hong Wang, Quan Zhou
BACKGROUND: Skeletal muscle relaxants (SMRs) are widely used in treating musculoskeletal conditions. All SMRs, with the exception of baclofen and tizanidine, are on the list of 2023 American Geriatrics Society Beers Criteria® for potentially inappropriate medication use in older adults. In our geriatric practice, off-label use of tizanidine as preemptive analgesia drove us to find recent advances in its pharmacology and therapeutics. An update review of tizanidine was thus presented, aiming to bring the latest knowledge to clinicians and promote further research and practical exploration...
2024: Journal of Pain Research
https://read.qxmd.com/read/38528637/cellular-and-molecular-mechanisms-involved-in-the-analgesic-effects-of-botulinum-neurotoxin-a-literature-review
#25
REVIEW
Saereh Hosseindoost, Seyed Hassan Inanloo, Seyed Khalil Pestehei, Mojgan Rahimi, Reza Atef Yekta, Alireza Khajehnasiri, Maziyar Askari Rad, Hossein Majedi, Ahmad Reza Dehpour
Botulinum neurotoxins (BoNTs), derived from Clostridium botulinum, have been employed to treat a range of central and peripheral neurological disease. Some studies indicate that BoNT may be beneficial for pain conditions as well. It has been hypothesized that BoNTs may exert their analgesic effects by preventing the release of pain-related neurotransmitters and neuroinflammatory agents from sensory nerve endings, suppressing glial activation, and inhibiting the transmission of pain-related receptors to the neuronal cell membrane...
April 2024: Drug Development Research
https://read.qxmd.com/read/38528610/metastasis-of-serous-ovarian-carcinoma-to-the-breast-a-case-report-and-review-of-the-literature
#26
REVIEW
Sofia Dueño, Rachel Stein, Mohsin Jamal, Gregory Lewis, Karina Hew
BACKGROUND: Breast metastasis from primary ovarian cancer is rare, with an estimated frequency of 0.07%. More than 110 cases are reported in the literature of metastatic spread of ovarian cancer to the breast and axilla. This entity usually represents aggressive late disease characterized by multi-drug chemoresistance and a poor prognosis with a median survival time of 16 months. Currently no standardized treatment protocol exists for this condition. CASE PRESENTATION: We present a case of a 59-year-old Caucasian female with recurrent high-grade serous ovarian cancer who was diagnosed with symptomatic unilateral breast metastasis while on fourth line chemotherapy with weekly paclitaxel...
March 26, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38528586/cortical-lipid-metabolic-pathway-alteration-of-early-alzheimer-s-disease-and-candidate-drugs-screen
#27
JOURNAL ARTICLE
Linshuang Wang, Fengxue Qu, Xueyun Yu, Sixia Yang, Binbin Zhao, Yaojing Chen, Pengbo Li, Zhanjun Zhang, Junying Zhang, Xuejie Han, Dongfeng Wei
BACKGROUND: Lipid metabolism changes occur in early Alzheimer's disease (AD) patients. Yet little is known about metabolic gene changes in early AD cortex. METHODS: The lipid metabolic genes selected from two datasets (GSE39420 and GSE118553) were analyzed with enrichment analysis. Protein-protein interaction network construction and correlation analyses were used to screen core genes. Literature analysis and molecular docking were applied to explore potential therapeutic drugs...
March 25, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38527585/comprehensive-analysis-of-a-widely-pharmaceutical-furosemide-and-its-degradation-products-in-aquatic-systems-occurrence-fate-and-ecotoxicity
#28
REVIEW
Fidji Sandre, Régis Moilleron, Christophe Morin, Laure Garrigue-Antar
Many pharmaceutical compounds end up in the environment due to incomplete removal by wastewater treatment plants (WWTPs). Some compounds are sometimes present in significant concentrations and therefore represent a risk to the aquatic environment. Furosemide is one of the most widely used drugs in the world. Considered as an essential drug by the World Health Organization, this powerful loop diuretic is used extensively to treat hypertension, heart and kidney failure and many other purposes. However, this important consumption also results in a significant release of furosemide in wastewater and in the receiving environment where concentrations of a few hundred ng/L to several thousand have been found in the literature, making furosemide a compound of great concern...
March 23, 2024: Environmental Pollution
https://read.qxmd.com/read/38527281/brigatinib-combined-with-cetuximab-in-the-fifth-line-treatment-of-non-small-cell-lung-cancer-with-egfr-p-c797s-mutation-in-critically-ill-patients-a-report-of-two-cases-and-literature-review
#29
JOURNAL ARTICLE
Juanjuan Liu, Hongtao Lei, Ding Zhang, Ning Zhang
For critically ill patients with non-small cell lung cancer (NSCLC) in need of life-saving treatment, there is currently no reported evidence regarding the use of medication specifically targeting epidermal growth factor receptor (EGFR) p.C797S mutation, which is known to cause resistance to third-generation tyrosine kinase inhibitors (TKIs). Our report aims to investigate and explore treatment strategies to overcome resistance associated with EGFR p.C797S mutation in order to provide potential therapeutic options for these patients...
March 15, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38526401/how-the-food-and-drug-administration-drug-approval-process-relates-to-the-potential-approval-of-intravenous-racemic-ketamine-for-treatment-resistant-major-depression
#30
JOURNAL ARTICLE
Sheldon H Preskorn
This column focuses on the status of intravenous racemic ketamine for the treatment of patients suffering from a form of major depressive disorder that does not respond to trials of currently available biogenic amine antidepressants. To provide context, the column reviews the 3 pivotal elements of the usual Food and Drug Administration (FDA) drug approval process: (1) the unmet medical need (ie, the indication) for which the drug is being developed, (2) the efficacy of the drug for that condition, and (3) the safety/tolerability of the drug...
March 1, 2024: Journal of Psychiatric Practice
https://read.qxmd.com/read/38526051/updated-antimicrobial-dosing-recommendations-for-obese-patients
#31
REVIEW
Ana Castro-Balado, Iria Varela-Rey, Beatriz Mejuto, Cristina Mondelo-García, Irene Zarra-Ferro, Teresa Rodríguez-Jato, Anxo Fernández-Ferreiro
The prevalence of obesity has increased considerably in the last few decades. Pathophysiological changes in obese patients lead to pharmacokinetic (PK) and pharmacodynamic (PD) alterations that can condition the correct exposure to antimicrobials if standard dosages are used. Inadequate dosing in obese patients can lead to toxicity or therapeutic failure. In recent years, additional antimicrobial PK/PD data, extended infusion strategies, and studies in critically ill patients have made it possible to obtain data to provide a better dosage in obese patients...
March 25, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38526023/review-article-recent-advances-in-ascites-and-acute-kidney-injury-management-in-cirrhosis
#32
REVIEW
Danielle Adebayo, Florence Wong
BACKGROUND: Better understanding of disease pathophysiology has led to advances in managing ascites and its associated complications including hepatorenal syndrome-acute kidney Injury (HRS-AKI), especially medicinal and interventional advances. AIM: To review the latest changes in the management of ascites and HRS-AKI. METHODS: A literature search was conducted in Pubmed, using the keywords cirrhosis, ascites, renal dysfunction, acute kidney injury, hepatorenal syndrome, beta-blockers, albumin, TIPS and vasoconstrictors, including only publications in English...
March 25, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38525952/postinjection-protocols-following-platelet-rich-plasma-administration-for-knee-osteoarthritis-a-systematic-review
#33
JOURNAL ARTICLE
Oscar Paul Levine, Koushik Kondapi, Vehniah Kristin Tjong, Chetan Gohal
OBJECTIVE: Platelet-rich plasma (PRP) use in treating orthopedic conditions has increased, yet evidence of its clinical efficacy is inconsistent and limited by heterogeneity in osteoarthritis (OA) severity, PRP preparations and protocols, and clinical outcome measurement. This review aims to characterize the variations in postinjection protocols in studies assessing the clinical efficacy of PRP for knee OA. LITERATURE SURVEY: A systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
March 25, 2024: PM & R: the Journal of Injury, Function, and Rehabilitation
https://read.qxmd.com/read/38525922/a-systematic-literature-review-on-the-use-of-dried-biofluid-microsampling-in-patients-with-kidney-disease
#34
REVIEW
Megan K Lamond, Andrew J Chetwynd, Alan D Salama, Louise Oni
BACKGROUND: Kidney disease is fairly unique due to the lack of symptoms associated with disease activity, and it is therefore dependent on biological monitoring. Dried biofluids, particularly dried capillary blood spots, are an accessible, easy-to-use technology that have seen increased utility in basic science research over the past decade. However, their use is yet to reach the kidney patient population clinically or in large-scale discovery science initiatives. The aim of this study was to systematically evaluate the existing literature surrounding the use of dried biofluids in kidney research...
March 25, 2024: Journal of Clinical Laboratory Analysis
https://read.qxmd.com/read/38525728/a-systematic-review-of-naldemedine-and-naloxegol-for-the-treatment-of-opioid-induced-constipation-in-cancer-patients
#35
REVIEW
Ursula K Braun, Leanne K Jackson, Mary A Garcia, Syed N Imam
BACKGROUND: Opioid-induced constipation (OIC) is a pervasive and distressing side effect of chronic opioid therapy in patients with cancer pain, significantly impacting their quality of life. Peripherally acting μ-opioid receptor antagonists (PAMORAS) were developed for treatment-resistant OIC but most studies were conducted with non-cancer patients. OBJECTIVE: to discuss two oral formulations of PAMORAs, naldemedine and naloxegol, and to review available evidence of the effectiveness of these drugs for OIC in cancer patients...
March 6, 2024: Pharmacy (Basel, Switzerland)
https://read.qxmd.com/read/38525684/navigating-the-usher-syndrome-genetic-landscape-an-evaluation-of-the-associations-between-specific-genes-and-quality-categories-of-cochlear-implant-outcomes
#36
REVIEW
Micol Busi, Alessandro Castiglione
Usher syndrome (US) is a clinically and genetically heterogeneous disorder that involves three main features: sensorineural hearing loss, retinitis pigmentosa (RP), and vestibular impairment. With a prevalence of 4-17/100,000, it is the most common cause of deaf-blindness worldwide. Genetic research has provided crucial insights into the complexity of US. Among nine confirmed causative genes, MYO7A and USH2A are major players in US types 1 and 2, respectively, whereas CRLN1 is the sole confirmed gene associated with type 3...
February 26, 2024: Audiology Research
https://read.qxmd.com/read/38525640/lsd-and-psilocybin-for-chronic-nociplastic-pain-a-narrative-review-of-the-literature-supporting-the-use-of-classic-psychedelic-agents-in-chronic-pain
#37
REVIEW
J Van Der Walt, R Parker
Healthcare providers face the challenging task of managing patients who suffer from chronic nociplastic pain conditions. Pain is a multidimensional experience, and the current approach to managing people in chronic pain often fails to meet the needs of these patients. Novel ways of treating people who suffer from chronic nociplastic pain with classic psychedelic agents may offer a new lens through which to approach their pain. Lysergic acid diethylamide (LSD) and psilocybin are both serotonergic agents with a long history of use in treating people with chronic pain and mental health disorders...
November 6, 2023: South African Medical Journal
https://read.qxmd.com/read/38525634/wrong-route-drug-administration-errors-a-review-of-the-literature
#38
JOURNAL ARTICLE
J Taylor, M Blockman
Oral drug formulations and enteral feeds may inadvertently be administered intravenously. Intravenous medications may be inadvertently administered intra-arterially. These examples of wrong-route drug administration errors have the potential to cause significant organ dysfunction and even death. This narrative review aims to explore the pathophysiological mechanisms underlying such errors and investigate preventive strategies and potential therapeutic options.
December 4, 2023: South African Medical Journal
https://read.qxmd.com/read/38525398/the-application-of-artificial-intelligence-and-drug-repositioning-for-the-identification-of-fibroblast-growth-factor-receptor-inhibitors-a-review
#39
REVIEW
Parvin Zarei, Fahimeh Ghasemi
Artificial intelligence talks about modeling intelligent behavior through a computer with the least human involvement. Drug repositioning techniques based on artificial intelligence accelerate the research process and decrease the cost of experimental studies. Dysregulation of fibroblast growth factor (FGF) receptors as the tyrosine kinase family of receptors plays a vital role in a wide range of malignancies. Because of their functional significance, they were considered promising drug targets for the therapy of various cancers...
2024: Advanced Biomedical Research
https://read.qxmd.com/read/38524957/olanzapine-samidorphan-for-schizophrenia-a-systematic-review-and-meta-analysis
#40
REVIEW
Dhyuti Gupta, Alok Singh
BACKGROUND AND OBJECTIVE: United States Food and Drug Administration (USFDA) recently approved a novel combination of olanzapine-samidorphan (OLZSAM) for managing olanzapine-associated adverse events (weight gain) in adult patients with schizophrenia and bipolar disorder. To opine about the safety and efficacy of OLZSAM, authors performed a systematic review and meta-analysis to convene justifiable evidence. METHODS: A thorough literature search was performed through the databases Embase, Cochrane Library, PubMed, and clinicaltrials...
January 2024: Indian Journal of Psychological Medicine
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