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https://www.readbyqxmd.com/read/29908451/inhibitors-of-protein-protein-interactions-ppis-an-analysis-of-scaffold-choices-and-buried-surface-area
#1
REVIEW
Xu Ran, Jason E Gestwicki
Protein-protein interactions (PPI) were once considered 'undruggable', but clinical successes, driven by advanced methods in drug discovery, have challenged that notion. Here, we review the last three years of literature on PPI inhibitors to understand what is working and why. From the 66 recently reported PPI inhibitors, we found that the average molecular weight was significantly greater than 500Da, but that this trend was driven, in large part, by the contribution of peptide-based compounds. Despite differences in average molecular weight, we found that compounds based on small molecules or peptides were almost equally likely to be potent inhibitors (KD <1μM)...
June 13, 2018: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/29908148/the-value-of-u-s-pharmacopeial-standards-a-review-of-the-literature
#2
James Heyward, William Padula, Jonothan C Tierce, G Caleb Alexander
While there are many standard-setting health care organizations, the United States Pharmacopeia's (USP) role includes the creation of documentary and physical standards for therapeutics, including chemical drugs, excipients and biologics. Despite the ubiquity of these standards, little work has been done to characterize and quantify their value. We reviewed the peer-reviewed and grey literature relevant to such evaluations. The review yielded 36 articles, focused variously on accreditation and other standards in healthcare, the broad impact of pharmacopeial standards, and evaluations of specific USP standards...
June 13, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29907742/nmda-antagonists-for-treating-the-non-motor-symptoms-in-parkinson-s-disease
#3
REVIEW
Brigitte Vanle, William Olcott, Jaime Jimenez, Luma Bashmi, Itai Danovitch, Waguih William IsHak
Among patients with Parkinson's disease (PD), depression is prevalent and disabling, impacting both health outcomes and quality of life. There is a critical need for alternative pharmacological methods to treat PD depression, as mainstream antidepressant drugs are largely ineffective in this population. Currently, there are no recommendations for the optimal treatment of PD neuropsychiatric symptoms. Given the dual antidepressant and anti-dyskinetic effects of ketamine and other N-methyl-D-aspartate (NMDA) antagonists for PD, this review aims to examine the current evidence of NMDA antagonists for treating neuropsychiatric symptoms, including memantine, amantadine, ketamine, dizoclopine, and d-cycloserine...
June 15, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29907475/radiotherapy-for-langerhans-cell-histiocytosis-with-paraplegia-a-rare-oncologic-emergency-case-report-in-infancy-and-literature-review
#4
Kentaro Nakashima, Yuhki Koga, Yasunari Sakai, Hidetoshi Takada, Katsumi Harimaya, Saiji Ohga, Tomoaki Taguchi, Yoshinao Oda, Hiroshi Honda, Shouichi Ohga
BACKGROUND: Langerhans cell histiocytosis (LCH) is a clonal disease with focal or disseminated lesions that may compress the surrounding tissues, including the spinal cord. Because few reports have described the spinal symptoms as the first manifestation of pediatric LCH, the long-term neurological outcomes remain unclear. CASE REPORT AND LITERATURE REVIEW: We report a 21-month-old boy who presented with sudden-onset paraplegia. Imaging analyses revealed that osteolytic lesions and epidural tumors compressing the spinal cord at the T7-9 vertebrae...
June 12, 2018: Brain & Development
https://www.readbyqxmd.com/read/29907456/state-of-the-art-analgesia-recent-developments-in-pharmacological-approaches-to-acute-pain-management-in-dogs-and-cats-part-1
#5
REVIEW
C A Bradbrook, L Clark
There has been considerable interest in acute pain management over recent years, focusing on pain assessment, pharmacological and non-pharmacological interventions. The evidence base for our clinical decision making and treatment of patients is increasing and becoming more robust. There is still a tendency to base some aspects of pain management on poor quality evidence and this requires further input in years to come. With new literature come new ideas and this review will detail the current knowledge base behind pharmacological management of acute pain in dogs and cats...
June 6, 2018: Veterinary Journal
https://www.readbyqxmd.com/read/29907117/increasing-evidence-of-low-lymphatic-filariasis-prevalence-in-high-risk-loa-loa-areas-in-central-and-west-africa-a-literature-review
#6
REVIEW
Louise A Kelly-Hope, Janet Hemingway, Mark J Taylor, David H Molyneux
In West and Central Africa, there is a need to establish the prevalence of Wuchereria bancrofti in areas that are co-endemic for Loa loa, in order to implement the appropriate strategies to scale-up interventions for the elimination of lymphatic filariasis (LF). Due to the risk of severe adverse events (SAEs) to ivermectin in individuals with high L. loa microfilaraemia, the current strategy recommended by the World Health Organization (WHO) is twice yearly mass drug administration (MDA) with albendazole, supplemented by vector control targeting the Anopheles vectors...
June 15, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29906718/review-adjunctive-pharmacologic-approaches-for-benzodiazepine-tapers
#7
REVIEW
Justine W Welsh, Valeria Tretyak, R Kathryn McHugh, Roger D Weiss, Olivera Bogunovic
BACKGROUND: Many patients require discontinuation of benzodiazepines due to a reduction in drug efficacy over time, the development of a sedative use disorder, or unwanted side effects. Benzodiazepine discontinuation can pose a significant challenge for prescribing clinicians due to potential withdrawal symptoms and a recurrence of psychiatric complaints. METHODS: A PubMed literature search was conducted using the medical subject heading of benzodiazepines in combination with the following key words: discontinuation, withdrawal, detoxification, cessation, dependence, addiction, substance use disorders, or long term...
May 31, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29906010/generalized-fixed-drug-eruption-to-piperacillin-tazobactam-and-review-of-literature
#8
Heather Kornmehl, Farzam Gorouhi, Thomas Konia, Maxwell A Fung, Danielle M Tartar
Fixed drug eruption (FDE) is an adverse drug reaction characterized by the development of well-circumscribed, round, dusky erythematous macules and plaques on cutaneous or mucosal surfaces. The reaction occurs on the same mucosal or cutaneous site with subsequent exposures to the offending drug. Although FDE usually manifests as a single lesion, in rare instances, more than one lesion may arise and this is referred to as a generalized eruption. Herein, we present a 31year-old man with history of cystic fibrosis who developed a generalized fixed drug eruption to piperacillin/tazobactam (Zosyn, Pfizer)...
April 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29905899/efficacy-and-safety-of-aripiprazole-for-the-treatment-of-schizophrenia-an-overview-of-systematic-reviews
#9
REVIEW
Esther Letícia Amorim Ribeiro, Tácio de Mendonça Lima, Marcio Eduardo Bergamini Vieira, Sílvia Storpirtis, Patricia Melo Aguiar
PURPOSE: To conduct an overview to summarize the efficacy and safety of aripiprazole for the treatment of schizophrenia. METHODS: A literature search was performed in PubMed, the Cochrane Library, LILACS, and the Centre for Reviews and Dissemination, for articles published until March 31, 2017. We included systematic reviews with meta-analyses of randomized controlled trials assessing the efficacy, and/or the safety of aripiprazole, for patients with schizophrenia...
June 15, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29905551/-modern-aspects-of-diagnosis-and-treatment-of-heart-failure-as-a-manifestation-of-anthracycline-cardiotoxicity-review
#10
Kh Saganelidze, N Kavtaradze
This review is devoted to the urgent problem of cardiology and oncology - the cardiotoxicity of chemotherapy drugs - anthracyclines, which are considered to be one of the most cardiotoxic and cause a variety of cardiotoxic effects. The review also examines the diagnosis, treatment or preventive treatment of this pathology. The urgency of the problem is associated with the possibility of early or late manifestations of cardiotoxicity, manifestations of cardiotoxicity against the background of cross treatment, manifestations of cardiotoxicity against the background of various concomitant diseases...
May 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29904814/dashboards-for-therapeutic-monoclonal-antibodies-learning-and-confirming
#11
Diane R Mould, Richard N Upton, Jessica Wojciechowski, Becky L Phan, Stacy Tse, Marla C Dubinsky
Inflammatory diseases (ID) are incurable, progressive diseases. Literature evidence cites increasing incidence of these diseases worldwide. When treatments with chemical immunosuppressive agents fail, patients are often treated with monoclonal antibodies (MAbs). However, MAb failure rates are generally high, with approximately half the patients being discontinued within 4 years, necessitating switching to another MAb. One potential cause of treatment failure is subtherapeutic exposure. Several studies demonstrated associations between trough MAb concentrations and clinical response, supporting the notion that improving drug exposure may result in improved outcomes...
June 14, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29904418/acquired-hypophosphatemic-osteomalacia-is-easily-misdiagnosed-or-neglected-by-rheumatologists-a-report-of-9-cases
#12
Ling Li, Shu-Xia Wang, Hong-Mei Wu, Dong-Lan Luo, Guang-Fu Dong, Yuan Feng, Xiao Zhang
The aim of the present study was to assist rheumatologists in differentiating hypophosphatemic osteomalacia (HO) from mimic rheumatology diseases. Clinical data was obtained from 9 patients with acquired HO, initially misdiagnosed as mimic rheumatologic diseases. The data were retrospectively analyzed and a literature review was performed. The etiology of the cases was as follows: Adefovir dipivoxil-induced Fanconi syndrome was present in 6 of the cases, 2 were tumors and 1 case was chronic nephropathy. The chief complaint was thoracic or back pain and arthralgia, followed by progressive muscle weakness and dramatic movement limitation...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904293/ah-7921-a-review-of-previously-published-reports
#13
REVIEW
Kerry Anne Rambaran, Zubair M Amin, Steven W Fleming, Liza Chacko, Saeed K Alzghari
AH-7921 is a synthetic opioid that was developed in the early 1970s. It has resulted in several fatal and nonfatal intoxications, despite not having approval from the US Food and Drug Administration. To date, AH-7921 is listed as a schedule I drug, and there have been no clinical trials exploring the safety of AH-7921. Herein, we provide an analysis of existing case reports available in the literature regarding AH-7921. We searched PubMed, Scopus, Web of Science, and EBSCO for articles (up until December 2017) using the terms "AH-7921" and "AH7921...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29904284/new-drug-developments-for-neuromuscular-blockade-and-reversal-gantacurium-cw002-cw011-and-calabadion
#14
REVIEW
Hans Donald de Boer, Ricardo Vieira Carlos
Purpose of Review: The purpose of this chapter is to provide a brief review of the literature on the recent developments in neuromuscular blockade and reversal agents. Recent Findings: Novel drug development resulted in pharmacological advancements in neuromuscular management and led to a new series of compounds, chlorofumarates, such as gantacurium, CW002, and CW011. These drugs have a fast onset and rapid to intermediate duration of action and can be rapidly reversed by l-cysteine adduction without side effects that are commonly observed with anticholinesterase reversal drugs...
2018: Current Anesthesiology Reports
https://www.readbyqxmd.com/read/29903696/types-and-frequency-of-infusion-pump-alarms-protocol-for-a-retrospective-data-analysis
#15
Kevin R Glover, Rachel R Vitoux, Catherine Schuster, Christopher R Curtin
BACKGROUND: The variety of alarms from all types of medical devices has increased from 6 to 40 in the last three decades, with today's most critically ill patients experiencing as many as 45 alarms per hour. Alarm fatigue has been identified as a critical safety issue for clinical staff that can lead to potentially dangerous delays or nonresponse to actionable alarms, resulting in serious patient injury and death. To date, most research on medical device alarms has focused on the nonactionable alarms of physiological monitoring devices...
June 14, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29903667/-the-most-common-stopp-start-criteria-in-spain-a-review-of-the-literature
#16
Esther Salgueiro, Bryana Candelaria Elizarde, Ana Isabel Elola, Beatriz García-Pulido, María Luisa Nicieza-García, Gloria Manso
OBJECTIVE: To analyse STOPP/START criteria found most frequently in the studies carried out in Spain, in order to identify the main areas of potentially inappropriate prescribing. METHODS: A literature review was carried out on the original studies performed in Spain that applied the original version of the STOPP/START criteria and that described the most common STOPP and/or START criteria found. In each study, a weighted analysis was performed on the criteria found, by assigning 5 points to the criterion in first position, 4 points to the criterion in second position, and so on to fifth criterion...
June 11, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29903464/paradoxical-reactions-to-biologic-therapy-in-psoriasis-a-review-of-the-literature
#17
M Munera-Campos, F Ballesca, J M Carrascosa
Biologic drugs, which are molecules designed to act on specific immune system targets, have been shown to be very effective in treating various dermatological, rheumatological, and systemic diseases. As a group, they have an acceptable safety profile, but their use has been associated with the onset of both systemic and organ-specific inflammatory conditions. True paradoxical reactions are immune-mediated disorders that would usually respond to the biologic agent that causes them. There is still debate about whether certain other adverse reactions can be said to be paradoxical...
June 11, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29901595/interventional-treatment-of-isolated-dissection-of-the-celiac-artery-a-case-report-and-literature-review
#18
Hai-Tao Wang, Zhi-Hai Yu, Can Tu, Bin Lu
RATIONALE: Isolated dissection of the celiac artery (IDCA) is one of isolated visceral artery dissection, which can occur alone, and can also be complicated with superior mesenteric artery dissection and splenic artery pseudoaneurysm. This disease is very rare in clinic. The exact pathogenesis of IDCA remains unknown. At present, no consensus has yet been reached on the best treatment strategy for this rare disease. In the present study, the clinical data of one IDCA patient diagnosed and treated in our hospital was retrospectively analyzed, and related literatures were reviewed, in order to improve the understanding of the disease...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29901473/management-of-adverse-reactions-to-first-line-tuberculosis-antibiotics
#19
Sowmya Nagarajan, Paul Whitaker
PURPOSE OF REVIEW: Tuberculosis (TB) is the commonest infectious cause of death globally. Adverse reactions to first-line tuberculosis antibiotics are common and have a major impact on the outcomes of patients as second-line antibiotics are less effective and more toxic. The present review addresses the most recent literature regarding epidemiology, investigating reactions, and reintroducing treatment in patients who have had their treatment interrupted. RECENT FINDINGS: Studies have demonstrated that up to 60% of patients experience adverse reactions to TB treatment; around a third of these are idiosyncratic and may relate to immune sensitization...
June 12, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29901471/examining-the-benefits-of-the-340b-drug-discount-program
#20
Jarrett Gerlach, Sarah McSweeney, Angela Swearingen, Alberto Coustasse
The 340B Drug Discount Program required drug manufacturers to provide discounted outpatient drugs to health care organizations serving vulnerable patient populations to allow these institutions to offer more services to more people. As the 340B program expanded, controversy centered on which entities have benefited from the program. Many health care organizations sold 340B drugs to well-insured patients at full price and have thus been financially rewarded. Amendments to the program have permitted 340B providers to use contract pharmacies to dispense 340B medications, furthering the debate over which stakeholders are benefiting from the program...
June 12, 2018: Health Care Manager
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