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https://www.readbyqxmd.com/read/29777102/a-virus-like-particle-based-tetravalent-vaccine-for-hand-foot-and-mouth-disease-elicits-broad-and-balanced-protective-immunity
#1
Wei Zhang, Wenlong Dai, Chao Zhang, Yu Zhou, Pei Xiong, Shuxia Wang, Xiaohua Ye, Qingwei Liu, Dongming Zhou, Zhong Huang
Hand, foot, and mouth disease (HFMD) is an infectious disease that mainly affects infants and children, causing considerable morbidity and mortality worldwide. HFMD is commonly caused by enterovirus 71 (EV71) and coxsackieviruses A16 (CVA16), A6 (CVA6), and A10 (CVA10). Formalin-inactivated EV71 vaccines are currently available in China; however, these vaccines fail to confer cross-protection against infections by other HFMD-causing enteroviruses, highlighting the necessity of developing a multivalent HFMD vaccine...
May 18, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29774519/zika-virus-baculovirus-expressed-virus-like-particles-induce-neutralizing-antibodies-in-mice
#2
Shiyu Dai, Tao Zhang, Yanfang Zhang, Hualin Wang, Fei Deng
The newly emerged mosquito-borne Zika virus (ZIKV) strains pose a global challenge owing to its ability to cause microcephaly and neurological disorders. Several ZIKV vaccine candidates have been proposed, including inactivated and live attenuated virus vaccines, vector-based vaccines, DNA and RNA vaccines. These have been shown to be efficacious in preclinical studies in mice and nonhuman primates, but their use will potentially be a threat to immunocompromised individuals and pregnant women. Virus-like particles (VLPs) are empty particles composed merely of viral proteins, which can serve as a safe and valuable tool for clinical prevention and treatment strategies...
May 17, 2018: Virologica Sinica
https://www.readbyqxmd.com/read/29765035/efficacy-of-a-respiratory-syncytial-virus-vaccine-candidate-in-a-maternal-immunization-model
#3
Jorge C G Blanco, Lioubov M Pletneva, Lori McGinnes-Cullen, Raymonde O Otoa, Mira C Patel, Lurds R Fernando, Marina S Boukhvalova, Trudy G Morrison
Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants. Maternal immunization is an option to increase maternal antibody levels and protect infants from infection. Here we assess the efficacy of virus-like particle (VLP) vaccine candidates containing stabilized pre-fusion (pre-F) or post-fusion (post-F) conformations of the RSV F protein and the attachment RSV G protein in a maternal immunization model using cotton rats. VLP vaccines containing RSV F and G proteins strongly boost pre-existing RSV immunity in dams preventing their perinatal drop in immunity...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29760798/a-multicenter-retrospective-comparison-of-sequential-versus-sandwich-chemoradiotherapy-for-stage-ie-iie-extranodal-natural-killer-t-cell-lymphoma-nasal-type
#4
Jin Li, Yajun Li, Meizuo Zhong, Wei Liu, Xianling Liu, Jiwei Li, Kunlun Li, Pingyong Yi
Background: Chemotherapy and radiotherapy are critical for treating early-stage extranodal natural killer/T-cell lymphoma, nasal type (ENKTL); however, the optimal therapy sequence remains unclear. Therefore, we performed this study to compare the efficacy of L-asparaginase/pegaspargase-based sequential versus sandwich chemoradiotherapy for patients newly diagnosed with stage IE-IIE ENKTL. Methods: Patients were categorized into sequential ( N = 111) and sandwich ( N = 104) groups. Chemotherapy regimens included GELOX, SMILE, and VLP...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29748549/genotype-i-of-japanese-encephalitis-virus-virus-like-particles-elicit-sterilizing-immunity-against-genotype-i-and-iii-viral-challenge-in-swine
#5
Yi-Chin Fan, Jo-Mei Chen, Jen-Wei Lin, Yi-Ying Chen, Guan-Hong Wu, Kuan-Hsuan Su, Ming-Tang Chiou, Shang-Rung Wu, Ji-Hang Yin, Jiunn-Wang Liao, Gwong-Jen J Chang, Shyan-Song Chiou
Swine are a critical amplifying host involved in human Japanese encephalitis (JE) outbreaks. Cross-genotypic immunogenicity and sterile protection are important for the current genotype III (GIII) virus-derived vaccines in swine, especially now that emerging genotype I (GI) JE virus (JEV) has replaced GIII virus as the dominant strain. Herein, we aimed to develop a system to generate GI JEV virus-like particles (VLPs) and evaluate the immunogenicity and protection of the GI vaccine candidate in mice and specific pathogen-free swine...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743369/intrastructural-help-harnessing-t-helper-cells-induced-by-licensed-vaccines-for-improvement-of-hiv-env-antibody-responses-to-virus-like-particle-vaccines
#6
Hassan Elsayed, Ghulam Nabi, William J McKinstry, Keith K Khoo, Johnson Mak, Andres M Salazar, Matthias Tenbusch, Vladimir Temchura, Klaus Überla
Induction of persistent antibody responses by vaccination is generally thought to depend on efficient help by T follicular helper cells. Since the T helper cell response to HIV Env may not be optimal, we explored the possibility to improve the HIV Env antibody response to virus-like particle (VLP) vaccines by recruiting T helper cells induced by a commonly-used licensed vaccines to provide help for Env-specific B cells. B cells specific for the surface protein of a VLP can internalize the entire VLP and thus present peptides derived from the surface and core proteins on their MHC-II molecules...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29715877/high-angular-resolution-visible-light-positioning-using-a-quadrant-photodiode-angular-diversity-aperture-receiver-qada
#7
Stefanie Cincotta, Cuiwei He, Adrian Neild, Jean Armstrong
The increasing use of white LEDs for indoor illumination provides a significant opportunity for Visible Light Positioning (VLP). The challenge is to design a small, unobtrusive sensor that can be incorporated into mobile devices to provide accurate measurements for triangulation. We present experimental results for a novel angle of arrival (AOA) detector that has been designed for use in a VLP system. The detector is composed of a transparent aperture in an opaque screen that is located above a quadrant photodiode (PD), separated by a known vertical distance...
April 2, 2018: Optics Express
https://www.readbyqxmd.com/read/29712887/short-course-versus-long-course-chemoradiotherapy-for-stage-ie-iie-extranodal-natural-killer-t-cell-lymphoma-nasal-type-a-multicenter-retrospective-study
#8
Jin Li, Yajun Li, Meizuo Zhong, Xianling Liu, Yinghui Song, Jiwei Li, Kunlun Li, Pingyong Yi
BACKGROUND This study compared clinical outcomes and adverse events between L-asparaginase/pegaspargase-based short-course and long-course chemoradiotherapy in newly diagnosed stage IE-IIE extranodal natural killer/T cell lymphoma, nasal type (ENKTL). MATERIAL AND METHODS Patients were categorized into a short-course (2-4 chemotherapy cycles, median: 4, n=153) and long-course group (5-6 cycles, median: 6, n=83). The chemotherapy regimens included GELOX, SMILE, and VLP. The radiotherapy dose was 40-63 Gy (median: 55 Gy)...
May 1, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29695428/electrostatic-interactions-between-hendra-virus-matrix-proteins-are-required-for-efficient-virus-like-particle-assembly
#9
Yu Chih Liu, Julian Grusovin, Timothy E Adams
Hendra virus (HeV) is a zoonotic paramyxovirus belonging to the genus Henipavirus. HeV is highly pathogenic, and it can cause severe neurological and respiratory illnesses in both humans and animals, with an extremely high mortality rate of up to 70%. Amongst the genes that HeV encodes, the matrix (M) protein forms an integral part of the virion structure and plays critical roles in coordinating viral assembly and budding. Nevertheless, the molecular mechanism of this process is not fully elucidated. Here, we determined the crystal structure of HeV M to 2...
April 25, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29695422/isg-expression-screening-reveals-the-specific-antibunyaviral-activity-of-isg20
#10
Junjie Feng, Arthur Wickenhagen, Matthew L Turnbull, Veronica V Rezelj, Felix Kreher, Natasha L Tilston-Lunel, Gillian S Slack, Benjamin Brennan, Elina Koudriakova, Andrew E Shaw, Suzannah J Rihn, Charles M Rice, Paul D Bieniasz, Richard M Elliott, Xiaohong Shi, Sam J Wilson
Bunyaviruses pose a significant threat to human health, prosperity and food security. In response to viral infections, interferons (IFNs) upregulate the expression of hundreds of interferon stimulated genes (ISGs) whose cumulative action can potently inhibit the replication of bunyaviruses. We used a flow cytometry-based method to screen the ability of ∼500 unique ISGs from humans and rhesus macaques to inhibit the replication of Bunyamwera orthobunyavirus (BUNV), the prototype of both the Peribunyaviridae family and Bunyavirales order...
April 25, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29691437/immunological-responses-following-administration-of-a-genotype-1a-1b-2-3a-quadrivalent-hcv-vlp-vaccine
#11
D Christiansen, L Earnest-Silveira, B Chua, P Meuleman, I Boo, B Grubor-Bauk, D C Jackson, Z Y Keck, S K H Foung, H E Drummer, E J Gowans, J Torresi
The significant public health problem of Hepatitis C virus (HCV) has been partially addressed with the advent of directly acting antiviral agents (DAAs). However, the development of an effective preventative vaccine would have a significant impact on HCV incidence and would represent a major advance towards controlling and possibly eradicating HCV globally. We previously reported a genotype 1a HCV viral-like particle (VLP) vaccine that produced neutralizing antibodies (NAb) and T cell responses to HCV. To advance this approach, we produced a quadrivalent genotype 1a/1b/2a/3a HCV VLP vaccine to produce broader immune responses...
April 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29683766/displaying-31rg-1-peptide-on-the-surface-of-hpv16-l1-by-use-of-a-human-papillomavirus-chimeric-virus-like-particle-induces-cross-neutralizing-antibody-responses-in-mice
#12
Xue Chen, Ting Zhang, Hongyang Liu, Yaru Hao, Guoyang Liao, Xuemei Xu
Current available human papillomavirus (HPV) vaccines are based on the major capsid protein L1 virus-like particles (VLPs), which mainly induce type-specific neutralizing antibodies against vaccine types. Continuing to add more types of VLPs in a vaccine raises the complexity and cost of production which remains the principal impediment to achieve broad implementation of HPV vaccines, particularly in developing regions. In this study, we constructed 16L1-31L2 chimeric VLP (cVLP) by displaying HPV31 L2 aa.17-38 on the h4 coil surface region of HPV16 L1, and assessed its immunogenicity in mouse model...
April 23, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29657475/incidence-of-tendon-rupture-following-volar-plate-fixation-of-distal-radius-fractures-a-survey-of-2787-cases
#13
Kotaro Sato, Kenya Murakami, Yoshikuni Mimata, Minoru Doita
This study assessed the comprehensive incidence of tendon rupture following volar locking plate (VLP) surgery for a large number of patients with distal radius fractures (DRFs) at multiple facilities in one prefecture, Japan. During the 4-year period, 2787 patients with DRFs underwent fixation using VLP. The overall incidence rates of rupture of the FPL, the extensor pollicis longus, the flexor digitorum profundus of the index finger, and the extensor digitorum communis were 0.35% (10 patients), 0.29% (8 patients), 0...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29650021/overexpression-of-a-type-iii-pks-gene-affording-novel-violapyrones-with-enhanced-anti-influenza-a-virus-activity
#14
Lukuan Hou, Huiming Huang, Huayue Li, Shuyao Wang, Jianhua Ju, Wenli Li
BACKGROUND: Type III polyketide synthases (PKSs) are simple homodimer ketosynthases that distribute across plants, fungi, and bacteria, catalyzing formation of pyrone- and resorcinol-types aromatic polyketides with various bioactivities. The broad substrate promiscuity displayed by type III PKSs makes them wonderful candidates for expanding chemical diversity of polyketides. RESULTS: Violapyrone B (VLP B, 10), an α-pyrone compound produced by deepsea-derived Streptomyces somaliensis SCSIO ZH66, is encoded by a type III PKS VioA...
April 12, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29624391/membrane-deformation-induces-clustering-of-norovirus-bound-to-glycosphingolipids-in-a-supported-cell-membrane-mimic
#15
Nagma Parveen, Inga Rimkute, Anders Oskar Lundgren, Stephan Block, Gustaf E Rydell, Daniel Midtvedt, Göran Larson, Vesa P Hytönen, Vladimir P Zhdanov, Fredrik Höök
Quartz crystal microbalance with dissipation monitoring and total internal reflection fluorescence microscopy have been used to investigate binding of norovirus-like particles (noroVLPs) to a supported (phospho)lipid bilayer (SLB) containing a few percent of H or B type 1 glycosphingolipid receptors. Although neither of these GSLs spontaneously form domains, noroVLPs were observed to form micron-sized clusters containing typically up to about 30 VLP copies, especially for B type 1 which is a higher-affinity receptor...
April 6, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29615100/ultrasonography-or-direct-radiography-a-comparison-of-two-techniques-to-detect-dorsal-screw-penetration-after-volar-plate-fixation
#16
Yunus Oc, Bekir Eray Kilinc, Anıl Gulcu, Ali Varol, Rodi Ertugrul, Adnan Kara
BACKGROUND: Complications related to extensor tendons have begun to increase with the use of volar plates in the treatment of distal radius fractures. In this study, we aimed to compare four-plane radiography and ultrasonography in the evaluation of dorsal cortex screw penetration following volar plate fixation. METHODS: We recruited 47 patients (33 males, 14 females, mean age 37.4 years; range 18-58 years). To evaluate dorsal screw penetration in all patients, we performed radiographs at 45° pronation, 45° supination and obtained dorsal tangential graphs at maximum palmar flexion, and a wrist lateral radiograph...
April 3, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29613803/treatment-of-canine-oral-melanoma-with-nanotechnology-based-immunotherapy-and-radiation
#17
P Jack Hoopes, Robert J Wagner, Kayla Duval, Kevin Kang, David J Gladstone, Karen L Moodie, Margaret Crary-Burney, Hugo Ariaspulido, Frank A Veliz, Nicole F Steinmetz, Steven Fiering
The presence and benefit of a radiation therapy-associated immune reaction is of great interest as the overall interest in cancer immunotherapy expands. Radiation therapy (RT) pathology studies have rarely demonstrated a consistent immune or inflammatory response following conventional RT. More recent information, primarily associated with the "abscopal effect", suggests a subtle radiation-based systemic immune response may be more common and have more therapeutic potential than previously believed...
April 3, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29609659/dengue-virus-like-particles-mimic-the-antigenic-properties-of-the-infectious-dengue-virus-envelope
#18
Stefan W Metz, Ashlie Thomas, Laura White, Mark Stoops, Markus Corten, Holger Hannemann, Aravinda M de Silva
BACKGROUND: The 4 dengue serotypes (DENV) are mosquito-borne pathogens that are associated with severe hemorrhagic disease. DENV particles have a lipid bilayer envelope that anchors two membrane glycoproteins prM and E. Two E-protein monomers form head-to-tail homodimers and three E-dimers align to form "rafts" that cover the viral surface. Some human antibodies that strongly neutralize DENV bind to quaternary structure epitopes displayed on E protein dimers or higher order structures forming the infectious virus...
April 2, 2018: Virology Journal
https://www.readbyqxmd.com/read/29582164/induction-of-a-high-titered-antibody-response-using-hiv-gag-ev71-vp1-based-virus-like-particles-with-the-capacity-to-protect-newborn-mice-challenged-with-a-lethal-dose-of-enterovirus-71
#19
Xi Wang, Ke Dong, Min Long, Fang Lin, Zhaowei Gao, Lin Wang, Zhe Zhang, Xi Chen, Ying Dai, Huiping Wang, Huizhong Zhang
Enterovirus 71 (EV71) is the most frequently detected causative agent in hand, foot, and mouth disease (HFMD) and is a serious threat to public health in the Asia-Pacific region. Many EV71 vaccines are under development worldwide, and although both inactivated virus vaccines and virus-like particles (VLPs) are considered to be effective, the main focus has been on inactivated EV71vaccines. There have been very few studies on EV71 VLPs. In this study, using a strategy based on HIV gag VLPs, we constructed a gag-VP1 fusion gene to generate a recombinant baculovirus expressing the EV71 structural protein VP1 together with gag, which was then used to infect TN5 cells to form VLPs...
March 27, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29576303/neutralization-effects-of-antibody-elicited-by-chimeric-hbv-s-antigen-viral-like-particles-presenting-hcv-neutralization-epitopes
#20
Sanhua Wei, Yingfeng Lei, Jie Yang, Xiaoyan Wang, Fang Shu, Xin Wei, Fang Lin, Bin Li, Ying Cui, Hai Zhang, Sanhua Wei
Hepatitis C virus (HCV) infection is a major public health problem despite effectual direct-acting antivirals (DAAs) therapy. Development of a prophylactic vaccine is essential to block spread of HCV infection. The HBV small surface antigen (HBsAg-S) can self-assemble into virus-like particles (VLPs), has higher immunogenicity and is used as a vaccine against HBV infections. Chimeric HBsAg-S proteins with foreign epitopes allow VLP formation and induce the specific humoral and cellular immune responses against the foreign proteins...
March 22, 2018: Vaccine
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