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Mediastinoscopy

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https://www.readbyqxmd.com/read/29776444/mediastinal-staging-of-non-small-cell-lung-cancer-by-endobronchial-and-endoscopic-ultrasonography-with-or-without-additional-surgical-mediastinoscopy-mediastrial-study-protocol-of-a-multicenter-randomised-controlled-trial
#1
Jelle E Bousema, Marcel G W Dijkgraaf, Nicole E Papen-Botterhuis, Hermien W Schreurs, Jos G Maessen, Erik H van der Heijden, Willem H Steup, Jerry Braun, Valentin J J M Noyez, Fieke Hoeijmakers, Naomi Beck, Martijn van Dorp, Niels J M Claessens, Birgitta I Hiddinga, Johannes M A Daniels, David J Heineman, Harmen R Zandbergen, Ad F T M Verhagen, Paul E van Schil, Jouke T Annema, Frank J C van den Broek
BACKGROUND: In case of suspicious lymph nodes on computed tomography (CT) or fluorodeoxyglucose positron emission tomography (FDG-PET), advanced tumour size or central tumour location in patients with suspected non-small cell lung cancer (NSCLC), Dutch and European guidelines recommend mediastinal staging by endosonography (endobronchial ultrasound (EBUS) and endoscopic ultrasound (EUS)) with sampling of mediastinal lymph nodes. If biopsy results from endosonography turn out negative, additional surgical staging of the mediastinum by mediastinoscopy is advised to prevent unnecessary lung resection due to false negative endosonography findings...
May 18, 2018: BMC Surgery
https://www.readbyqxmd.com/read/29764457/video-mediastinoscopy-assisted-fish-bone-extraction-and-superior-medistinal-abscess-debridement
#2
Jun Wang, Wei Bing Wu, Liang Chen, Quan Zhu
BACKGROUND: Mediastinum abscess caused by sharp esophageal foreign body perforation usually needs surgical treatment, and the surgical procedures vary according to size of perforation and scope of abscess, etc. For special case with small esophageal mucosal crevasse and focal abscess confined to mediastinum, minimally invasive surgery with guidance of video-mediastinoscopy would be an alternative method, however, application of video-mediastinoscopy in this life-threatening situation was rarely reported...
May 15, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29755101/-outcome-of-surgical-treatment-of-locally-advanced-lung-cancer-after-induction-chemoradiotherapy
#3
Masayuki Tanahashi, Haruhiro Yukiue, Eriko Suzuki, Naoko Yoshii, Shinsuke Kitazawa, Yasunori Kaminuma, Hiroshi Niwa
OBJECTIVE: The outcome of surgical treatment of non-small-cell lung cancer after induction chemoradiotherapy was investigated. SUBJECTS: The subjects were 74 patients with non-small-cell lung cancer who received induction chemoradiotherapy( ICRT) between 1998 and 2016. ICRT was administered to pT3 lung cancer invading the chest wall(20 patients), pT4 lung cancer invading the adjacent organ(22 patients), and cN2 lung cancer(32 patients). cN2 was confirmed by mediastinoscopy(13 patients) and endobronchial ultrasound-guided transbronchial needle aspiration(EBUS-TBNA)(19 patients)...
April 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29723532/the-persistent-problem-of-local-regional-failure-following-surgery-for-early-stage-lung-cancer
#4
Gregory D Judy, Orit Kaidar-Person, Allison Deal, Yue Wang, Andrew Migliardi, Jason Long, Benjamin Haithcock, Lawrence B Marks
BACKGROUND: The goal of the present study is to estimate the rate of local/regional failure (LRF) following definitive surgery for early stage non-small cell lung cancer (NSCLC) (without postoperative radiation) in the era of contemporary imaging and minimally invasive surgical techniques. METHODS: Retrospectively reviewed medical records of patients with early-stage NSCLC (pathologic T1-4, N0-1) who underwent lobectomy, sleeve lobectomy, bilobectomy, or pneumonectomy with/without adjuvant chemotherapy between 2007 and 2015...
April 30, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29707351/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-and-cervical-mediastinoscopy-for-mediastinal-staging-of-non-small-cell-lung-cancer-a-retrospective-comparison-study
#5
Rong Zhang, Yuxiang Ma, Guoliang Xu, Xiaoyan Gao, Guangyu Luo, Qingguang Lin, Yunpeng Yang, Xin Wang, Li Zhang
Background: Invasive mediastinal lymph node staging is essential to resectable non-small cell lung cancer (NSCLC) patients. This retrospective study aimed to compare the diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) against cervical mediastinoscopy (CMS) in radiologically enlarged mediastinal lymph nodes. Methods: Retrospective data were collected from January 2009 to March 2016. Suspected lung cancer patients with enlarged mediastinal lymph nodes (short axis ≥10 mm), underwent EBUS-TBNA or CMS for invasive mediastinal staging were enrolled...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29701377/smajor-hemorrahage-during-mediastinoscopy-do-you-panic-or-do-you-have-a-protocol
#6
Filipa Madeira, Joana Cortesão, Rita Pancas, Teresa Paiva
INTRODUCTION: Although uncommon, major vessel hemorrhage is the most feared complication of mediastinoscopy. Our goal was to determine the optimal management strategy and to develop a simple and accessible protocol for optimizing care in these situations. METHODS: Data collection after reviewing the relevant literature. A literature review was conducted using the following databases: PubMed, Medline, Embase and ScienceDirect. RESULTS: The protocol consists of three distinct parts - initial checklist, considerations in minor bleeding and performance in major bleeding...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701372/unusual-behavior-of-a-lung-inflammatory-myofibroblastic-tumor-case-report
#7
Cristina Rodrigues, Daniel Cabral, Teresa Almodovar, Analisa Ribeiro, Diogo Delgado, Leonor Mota, Samuel Mendes, Magda Alvoeiro, Carolina Torres, Telma Calado, Mariana Antunes, Francisco Félix
INTRODUCTION: 55 years old, male patient. History of heavy smoking (65 UMA) and COPD. Admitted to hospital due to a left pneumonia. Thoracic CT and PET-Scan, showed left lower lobe mass measuring 92x89 mm (SUVmax 49). Several mediastinal node groups presented increased uptake of FDG. A fiberoptic bronchoscopy was performed. Citology of the bronchoalveolar lavage suggested a squamous carcinoma. EBUS of node stations 4R, 4L e 7 without evidence of malignancy. METHODS: The case was taken to a multidisciplinary meeting staged as IIIA (T3N2M0)...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701370/major-complications-of-videomediastinoscopy-and-their-resolution-a-5-year-experience
#8
Ana Rita Costa, João Silva, João Eurico, Manuel Godinho, Rita Barata, Ivan Bravio, Paulo Calvinho, José Fragata
INTRODUCTION: Videomediastinoscopy is an invasive procedure for mediastinal assessment, with low rates of morbidity and mortality. Despite the low risk of complications, they can be potentially lethal if not immediately controlled. OBJECTIVE: The goal of this study is to analyse the overall incidence of complications of videomediastinoscopies, performed in the last 5 years at our department, as well as their resolution and outcomes. METHODS: A retrospective review of all videomediastinoscopies performed at a single institution during a 5-year period was performed...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29693234/a-retrospective-analysis-comparing-the-use-of-procore%C3%A2-with-standard-fine-needle-aspiration-in-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna
#9
David J McCracken, Melanie Bailey, Marie-Therese McDermott, Terence E McManus
Endobronchial ultrasound has become first line in the investigation of mediastinal lesions suspicious for malignancy in keeping with National Institute for Health and Care Excellence (NICE) guidelines; however, needle size and type required to maximise diagnostic sensitivity remains unclear. Previous meta-analyses have compared the use of ProCore with standard fine needle aspiration in the assessment of pancreatic masses with differences noted only in the number of passes required. We aim to assess whether a ProCore needle improves diagnostic sensitivity in EBUS-TBNA...
April 24, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29666815/endobronchial-ultrasound-transbronchial-needle-aspiration-ebus-tbna-a-diagnostic-challenge-for-mediastinal-lesions
#10
REVIEW
Duilio Divisi, Gino Zaccagna, Mirko Barone, Francesca Gabriele, Roberto Crisci
Lung cancer is one of the most frequent neoplastic diseases. To date, most lung cancer is diagnosed at an advanced stage, making it difficult to choose the diagnostic and therapeutic strategy. Surgical resection represents the best therapeutic solution. However, the best results are obtained only in the early stages of the disease. Lymph node involvement conditions the treatment (surgical or non-surgical approach). Mediastinoscopy is an effective and widely used method for mediastinal staging but does not allow us to reach many mediastinal lymph nodes...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29650028/a-rare-presentation-of-pulmonary-sarcoidosis-as-a-solitary-lung-mass-a-case-report
#11
Dylan W Kelleher, Madeleine Yaggi, Robert Homer, Erica L Herzog, Changwan Ryu
BACKGROUND: Sarcoidosis is a multisystem, chronic granulomatous disease of unknown etiology that predominantly affects the lungs. Pulmonary sarcoidosis classically presents with constitutional symptoms and computed tomographic scan findings of bilateral, symmetric micronodules in a peribronchovascular distribution with upper and middle lung zone predominance accompanied by bilateral, symmetric hilar lymphadenopathy. A solitary lung mass is a rare finding for pulmonary sarcoidosis, and with its associated constitutional symptoms, it strongly mimics a malignancy...
April 13, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29622075/staging-lung-cancer-regional-lymph-node-classification
#12
REVIEW
Ahmed H El-Sherief, Charles T Lau, Brett W Carter, Carol C Wu
This article reviews regional lymph node assessment in lung cancer. In the absence of a distant metastasis, the absence or location of lung cancer spread to a regional mediastinal lymph node affects treatment options and prognosis. Regional lymph node maps have been created to standardize assessment of the N descriptor. The International Association for the Study of Lung Cancer lymph node map is used for the standardization of N descriptor assessment. CT, PET/CT with fluorodeoxyglucose, endobronchial ultrasound-guided and/or esophageal ultrasound-guided biopsy, and mediastinoscopy are common modalities used to determine the N descriptor...
May 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29600073/microrna-expression-profile-in-primary-lung-cancer-cells-lines-obtained-by-endobronchial-ultrasound-transbronchial-needle-aspiration
#13
Juliana Guarize, Fabrizio Bianchi, Elena Marino, Elena Belloni, Manuela Vecchi, Stefano Donghi, Giorgio Lo Iacono, Chiara Casadio, Roberto Cuttano, Massimo Barberis, Pier Paolo Di Fiore, Francesco Petrella, Lorenzo Spaggiari
Background: Novel cancer biomarkers like microRNA (miRNA) are promising tools to gain a better understanding of lung cancer pathology and yield important information to guide therapy. In recent years, new less invasive methods for the diagnosis and staging of NSCLC have become key tools in thoracic oncology and the worldwide spread of endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA). However, appropriate specimen handling is mandatory to achieve adequate results and reproducibility...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29596820/patterns-of-practice-in-mediastinal-lymph-node-staging-for-non-small-cell-lung-cancer-in-canada
#14
Simon R Turner, Nazgol Seyednejad, Basil S Nasir
BACKGROUND: Assessment of mediastinal lymph nodes is integral in staging patients with non-small cell lung cancer (NSCLC). This study aims to delineate the lymph node staging practices of Canadian thoracic surgeons in patients with potentially resectable NSCLC. METHODS: A questionnaire was distributed to Canadian Association of Thoracic Surgeons members (n=86). Items addressed the use of imaging, thresholds/methods for preoperative invasive staging, and intraoperative node staging...
March 26, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29552519/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-for-staging-of-non-small-cell-lung-cancer
#15
Habiba Hashimi, David T Cooke, Elizabeth A David, Lisa M Brown
Accurate staging for non-small cell lung cancer (NSCLC) is essential to guide therapy. While computed tomography (CT) and positron emission tomography (PET) scan can indicate whether mediastinal lymphadenopathy is present, histologic confirmation is required to complete the staging evaluation. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive technique associated with similar diagnostic yield and improved postoperative pain and complication rates compared to mediastinoscopy...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29548327/mediastinoscopy-assisted-esophagectomy-for-t2-middle-and-lower-thoracic-esophageal-squamous-cell-carcinoma-patients
#16
Jun Wang, Ning Wei, Yimin Lu, Xiaoying Zhang, Nanqing Jiang
BACKGROUND: We aimed to compare mediastinoscopy-assisted esophagectomy (MAE) with the Ivor Lewis procedure in T2 middle and lower thoracic esophageal carcinoma patients in fields of perioperative complications and overall survival (OS). METHODS: The clinical data of 112 T2 esophageal cancer patients who received MAE (n = 31) or Ivor Lewis procedure (n = 81) from January 2010 to December 2015 were retrospectively analyzed in propensity score analysis. Thirty-eight T2 esophageal cancer patients who underwent MAE (n = 19) and Ivor Lewis procedure (n = 19) were included in this study...
March 16, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29535096/middle-mediastinal-schwannoma-concealed-by-asthma-and-gord
#17
Prudence Dy, Cristina Lajom, Josephino Sanchez
Neurogenic tumours of the mediastinum in adults occur most often at the posterior mediastinum, majority of which are benign of nerve sheath in origin. A 72-year-old woman, known asthmatic, presented with chronic symptoms of hoarseness, dysphagia, chest heaviness, easy fatigability, cough, epigastric pain, feeling of abdominal fullness and choking with food intake and at a supine position. Treated for other disorders, routine chest X-ray incidentally found a homogenous convex radiodensity at the right paratracheal area; mass which was also observed with CT and 18F-fludeoxyglucose-positron emission tomography/CT scan studies...
March 13, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29534904/variability-in-invasive-mediastinal-staging-for-lung-cancer-a-multicenter-regional-study
#18
Lucas W Thornblade, Douglas E Wood, Michael S Mulligan, Alexander S Farivar, Michal Hubka, Kimberly E Costas, Bahirathan Krishnadasan, Farhood Farjah
OBJECTIVE: Prior studies have reported underuse of-but not variability in-invasive mediastinal staging in the pretreatment evaluation of patients with lung cancer. We sought to compare rates of invasive mediastinal staging for lung cancer across hospitals participating in a regional quality improvement and research collaborative. METHODS: We conducted a retrospective study (2011-2013) of patients undergoing resected lung cancer from the Surgical Clinical Outcomes and Assessment Program in Washington State...
June 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29523217/adjuvant-chemotherapy-following-surgical-resection-improves-survival-in-patients-with-early-stage-small-cell-lung-cancer
#19
Yuanshan Yao, Yinjie Zhou, Zhenhua Yang, Hongbo Huang, Haibo Shen
The purpose of this study was to determine the effects of resection coupled with standard chemotherapy on survival prognosis of patients with early-stage small cell lung carcinoma (SCLC). Patients (n=110) with mediastinal lymph node-negative SCLC were enrolled in this study. The baseline clinical data of patients with surgery was retrospectively reviewed. Overall and progression-free survival were measured by Kaplan-Meier and log-rank test analyses. Ninety-eight patients received mediastinoscopy biopsy and pulmonary lobectomy or sublobar resection, and 67 patients underwent adjuvant chemotherapy after pulmonary lobectomy...
March 9, 2018: Oncology Research
https://www.readbyqxmd.com/read/29516896/mediastinal-ganglionar-tuberculosis-postcardiac-transplantation
#20
João Bruno Ribeiro Machado Lisboa, Guilherme de Abreu Rodrigues, Diego Corsetti Mondadori, João Paulo Cassiano de Macedo, Orival De Freitas Filho, Paulo Manuel Pêgo-Fernades
The diagnosis and treatment of tuberculosis (TB) in transplanted receivers presents several challenges. TB is an opportunistic infection with high morbidity and mortality in solid organs of transplanted patients, therefore, the diagnosis difficulties. A case of a 30-year-old male, heart transplanted patient, who after being submitted to mediastinoscopy, obtained a result of lymph node TB.
January 2018: International Journal of Mycobacteriology
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