K L Schneider, X Hao, K S Keuenhof, L L Berglund, A Fischbach, D Ahmadpour, S Chawla, P Gómez, J L Höög, P O Widlund, T Nyström
A major consequence of aging and stress, in yeast to humans, is an increased accumulation of protein aggregates at distinct sites within the cells. Using genetic screens, immunoelectron microscopy, and three-dimensional modeling in our efforts to elucidate the importance of aggregate annexation, we found that most aggregates in yeast accumulate near the surface of mitochondria. Further, we show that virus-like particles (VLPs), which are part of the retrotransposition cycle of Ty elements, are markedly enriched in these sites of protein aggregation...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America