keyword
https://read.qxmd.com/read/38602683/second-primary-breast-cancer-in-young-breast-cancer-survivors
#1
JOURNAL ARTICLE
Kristen D Brantley, Shoshana M Rosenberg, Laura C Collins, Kathryn J Ruddy, Rulla M Tamimi, Lidia Schapira, Virginia F Borges, Ellen Warner, Steven E Come, Yue Zheng, Gregory J Kirkner, Craig Snow, Eric P Winer, Ann H Partridge
IMPORTANCE: Among women diagnosed with primary breast cancer (BC) at or younger than age 40 years, prior data suggest that their risk of a second primary BC (SPBC) is higher than that of women who are older when they develop a first primary BC. OBJECTIVE: To estimate cumulative incidence and characterize risk factors of SPBC among young patients with BC. DESIGN, SETTING, AND PARTICIPANTS: Participants were enrolled in the Young Women's Breast Cancer Study, a prospective study of 1297 women aged 40 years or younger who were diagnosed with stage 0 to III BC from August 2006 to June 2015...
April 11, 2024: JAMA Oncology
https://read.qxmd.com/read/38594603/habitat-escalated-adaptive-therapy-heat-a-phase-2-trial-utilizing-radiomic-habitat-directed-and-genomic-adjusted-radiation-dose-gard-optimization-for-high-grade-soft-tissue-sarcoma
#2
JOURNAL ARTICLE
Arash O Naghavi, J M Bryant, Youngchul Kim, Joseph Weygand, Gage Redler, Austin J Sim, Justin Miller, Kaitlyn Coucoules, Lauren Taylor Michael, Warren E Gloria, George Yang, Stephen A Rosenberg, Kamran Ahmed, Marilyn M Bui, Evita B Henderson-Jackson, Andrew Lee, Caitlin D Lee, Ricardo J Gonzalez, Vladimir Feygelman, Steven A Eschrich, Jacob G Scott, Javier Torres-Roca, Kujtim Latifi, Nainesh Parikh, James Costello
BACKGROUND: Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic response (FPR ≥ 95%) from RT is associated with improved patient outcome. Genomic adjusted radiation dose (GARD), a radiation-specific metric that quantifies the expected RT treatment effect as a function of tumor dose and genomics, proposed that STS is significantly underdosed...
April 9, 2024: BMC Cancer
https://read.qxmd.com/read/38526578/british-societies-guideline-on-the-management-of-emergencies-in-implantable-left-ventricular-assist-device-recipients-in-transplant-centres
#3
JOURNAL ARTICLE
Waqas Akhtar, Veronica Rial Baston, Marius Berman, Sai Bhagra, Colin Chue, Charles D Deakin, Jonathan R Dalzell, Joel Dunning, John Dunning, Roy S Gardner, Kristine Kiff, Shishir Kore, Sern Lim, Guy MacGowan, Ian Naldrett, Marlies Ostermann, Sofia Pinto, Stephen Pettit, Fernando Riesgo Gil, Alex Rosenberg, Antonio Rubino, Rana Sayeed, Joao Sequeira, Neil Swanson, Steven Tsui, Christopher Walker, Stephen Webb, Andrew Woods, Rajamiyer Ventkateswaran, Christopher T Bowles
An implantable left ventricular assist device (LVAD) is indicated as a bridge to transplantation or recovery in the United Kingdom (UK). The mechanism of action of the LVAD results in a unique state of haemodynamic stability with diminished arterial pulsatility. The clinical assessment of an LVAD recipient can be challenging because non-invasive blood pressure, pulse and oxygen saturation measurements may be hard to obtain. As a result of this unusual situation and complex interplay between the device and the native circulation, resuscitation of LVAD recipients requires bespoke guidelines...
March 25, 2024: Intensive Care Medicine
https://read.qxmd.com/read/38499181/executive-summary-from-the-medical-board-of-the-national-psoriasis-foundation-perioperative-management-of-immunomodulatory-agents-in-patients-with-psoriasis-and-psoriatic-arthritis
#4
JOURNAL ARTICLE
Warren A James, Angela L Rosenberg, Jashin J Wu, Sylvia Hsu, April Armstrong, Elizabeth B Wallace, Lara Wine Lee, Joseph Merola, Sergio Schwartzman, Dafna Gladman, Clive Liu, John Koo, Jason E Hawkes, Soumya Reddy, Ron Prussick, Paul Yamauchi, Michael Lewitt, Jennifer Soung, Jeffery Weinberg, Mark Lebwohl, Brad Glick, Leon Kircik, Seemal Desai, Steven R Feldman, Mallory L Zaino
No abstract text is available yet for this article.
March 16, 2024: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/38415400/racial-and-ethnic-disparities-in-the-co-occurrence-of-intellectual-disability-and-autism-impact-of-incorporating-measures-of-adaptive-functioning
#5
JOURNAL ARTICLE
Sarah M Furnier, Ronald Gangnon, Julie L Daniels, Susan Ellis Weismer, Cy Nadler, Karen Pazol, Nuri M Reyes, Steven Rosenberg, Eric Rubenstein, Lisa D Wiggins, Marshalyn Yeargin-Allsopp, Maureen S Durkin
Intellectual disability (ID) commonly co-occurs in children with autism. Although diagnostic criteria for ID require impairments in both cognitive and adaptive functioning, most population-based estimates of the frequency of co-occurring ID in children with autism-including studies of racial and ethnic disparities in co-occurring autism and ID-base the definition of ID solely on cognitive scores. The goal of this analysis was to examine the effect of including both cognitive and adaptive behavior criteria on estimates of co-occurring ID in a well-characterized sample of 2- to 5-year-old children with autism...
February 28, 2024: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/38394591/achievement-of-target-gain-larger-than-unity-in-an-inertial-fusion-experiment
#6
JOURNAL ARTICLE
H Abu-Shawareb, R Acree, P Adams, J Adams, B Addis, R Aden, P Adrian, B B Afeyan, M Aggleton, L Aghaian, A Aguirre, D Aikens, J Akre, F Albert, M Albrecht, B J Albright, J Albritton, J Alcala, C Alday, D A Alessi, N Alexander, J Alfonso, N Alfonso, E Alger, S J Ali, Z A Ali, A Allen, W E Alley, P Amala, P A Amendt, P Amick, S Ammula, C Amorin, D J Ampleford, R W Anderson, T Anklam, N Antipa, B Appelbe, C Aracne-Ruddle, E Araya, T N Archuleta, M Arend, P Arnold, T Arnold, A Arsenlis, J Asay, L J Atherton, D Atkinson, R Atkinson, J M Auerbach, B Austin, L Auyang, A A S Awwal, N Aybar, J Ayers, S Ayers, T Ayers, S Azevedo, B Bachmann, C A Back, J Bae, D S Bailey, J Bailey, T Baisden, K L Baker, H Baldis, D Barber, M Barberis, D Barker, A Barnes, C W Barnes, M A Barrios, C Barty, I Bass, S H Batha, S H Baxamusa, G Bazan, J K Beagle, R Beale, B R Beck, J B Beck, M Bedzyk, R G Beeler, R G Beeler, W Behrendt, L Belk, P Bell, M Belyaev, J F Benage, G Bennett, L R Benedetti, L X Benedict, R L Berger, T Bernat, L A Bernstein, B Berry, L Bertolini, G Besenbruch, J Betcher, R Bettenhausen, R Betti, B Bezzerides, S D Bhandarkar, R Bickel, J Biener, T Biesiada, K Bigelow, J Bigelow-Granillo, V Bigman, R M Bionta, N W Birge, M Bitter, A C Black, R Bleile, D L Bleuel, E Bliss, E Bliss, B Blue, T Boehly, K Boehm, C D Boley, R Bonanno, E J Bond, T Bond, M J Bonino, M Borden, J-L Bourgade, J Bousquet, J Bowers, M Bowers, R Boyd, D Boyle, A Bozek, D K Bradley, K S Bradley, P A Bradley, L Bradley, L Brannon, P S Brantley, D Braun, T Braun, K Brienza-Larsen, R Briggs, T M Briggs, J Britten, E D Brooks, D Browning, M W Bruhn, T A Brunner, H Bruns, G Brunton, B Bryant, T Buczek, J Bude, L Buitano, S Burkhart, J Burmark, A Burnham, R Burr, L E Busby, B Butlin, R Cabeltis, M Cable, W H Cabot, B Cagadas, J Caggiano, R Cahayag, S E Caldwell, S Calkins, D A Callahan, J Calleja-Aguirre, L Camara, D Camp, E M Campbell, J H Campbell, B Carey, R Carey, K Carlisle, L Carlson, L Carman, J Carmichael, A Carpenter, C Carr, J A Carrera, D Casavant, A Casey, D T Casey, A Castillo, E Castillo, J I Castor, C Castro, W Caughey, R Cavitt, J Celeste, P M Celliers, C Cerjan, G Chandler, B Chang, C Chang, J Chang, L Chang, R Chapman, T D Chapman, L Chase, H Chen, H Chen, K Chen, L-Y Chen, B Cheng, J Chittenden, C Choate, J Chou, R E Chrien, M Chrisp, K Christensen, M Christensen, N S Christiansen, A R Christopherson, M Chung, J A Church, A Clark, D S Clark, K Clark, R Clark, L Claus, B Cline, J A Cline, J A Cobble, K Cochrane, B Cohen, S Cohen, M R Collette, G W Collins, L A Collins, T J B Collins, A Conder, B Conrad, M Conyers, A W Cook, D Cook, R Cook, J C Cooley, G Cooper, T Cope, S R Copeland, F Coppari, J Cortez, J Cox, D H Crandall, J Crane, R S Craxton, M Cray, A Crilly, J W Crippen, D Cross, M Cuneo, G Cuotts, C E Czajka, D Czechowicz, T Daly, P Danforth, C Danly, R Darbee, B Darlington, P Datte, L Dauffy, G Davalos, S Davidovits, P Davis, J Davis, S Dawson, R D Day, T H Day, M Dayton, C Deck, C Decker, C Deeney, K A DeFriend, G Deis, N D Delamater, J A Delettrez, R Demaret, S Demos, S M Dempsey, R Desjardin, T Desjardins, M P Desjarlais, E L Dewald, J DeYoreo, S Diaz, G Dimonte, T R Dittrich, L Divol, S N Dixit, J Dixon, A Do, E S Dodd, D Dolan, A Donovan, M Donovan, T Döppner, C Dorrer, N Dorsano, M R Douglas, D Dow, J Downie, E Downing, M Dozieres, V Draggoo, D Drake, R P Drake, T Drake, G Dreifuerst, O Drury, D F DuBois, P F DuBois, G Dunham, M Durocher, R Dylla-Spears, A K L Dymoke-Bradshaw, B Dzenitis, C Ebbers, M Eckart, S Eddinger, D Eder, D Edgell, M J Edwards, P Efthimion, J H Eggert, B Ehrlich, P Ehrmann, S Elhadj, C Ellerbee, N S Elliott, C L Ellison, F Elsner, M Emerich, K Engelhorn, T England, E English, P Epperson, R Epstein, G Erbert, M A Erickson, D J Erskine, A Erlandson, R J Espinosa, C Estes, K G Estabrook, S Evans, A Fabyan, J Fair, R Fallejo, N Farmer, W A Farmer, M Farrell, V E Fatherley, M Fedorov, E Feigenbaum, T Fehrenbach, M Feit, B Felker, W Ferguson, J C Fernandez, A Fernandez-Panella, S Fess, J E Field, C V Filip, J R Fincke, T Finn, S M Finnegan, R G Finucane, M Fischer, A Fisher, J Fisher, B Fishler, D Fittinghoff, P Fitzsimmons, M Flegel, K A Flippo, J Florio, J Folta, P Folta, L R Foreman, C Forrest, A Forsman, J Fooks, M Foord, R Fortner, K Fournier, D E Fratanduono, N Frazier, T Frazier, C Frederick, M S Freeman, J Frenje, D Frey, G Frieders, S Friedrich, D H Froula, J Fry, T Fuller, J Gaffney, S Gales, B Le Galloudec, K K Le Galloudec, A Gambhir, L Gao, W J Garbett, A Garcia, C Gates, E Gaut, P Gauthier, Z Gavin, J Gaylord, C G R Geddes, M Geissel, F Génin, J Georgeson, H Geppert-Kleinrath, V Geppert-Kleinrath, N Gharibyan, J Gibson, C Gibson, E Giraldez, V Glebov, S G Glendinning, S Glenn, S H Glenzer, S Goade, P L Gobby, S R Goldman, B Golick, M Gomez, V Goncharov, D Goodin, P Grabowski, E Grafil, P Graham, J Grandy, E Grasz, F R Graziani, G Greenman, J A Greenough, A Greenwood, G Gregori, T Green, J R Griego, G P Grim, J Grondalski, S Gross, J Guckian, N Guler, B Gunney, G Guss, S Haan, J Hackbarth, L Hackel, R Hackel, C Haefner, C Hagmann, K D Hahn, S Hahn, B J Haid, B M Haines, B M Hall, C Hall, G N Hall, M Hamamoto, S Hamel, C E Hamilton, B A Hammel, J H Hammer, G Hampton, A Hamza, A Handler, S Hansen, D Hanson, R Haque, D Harding, E Harding, J D Hares, D B Harris, J A Harte, E P Hartouni, R Hatarik, S Hatchett, A A Hauer, M Havre, R Hawley, J Hayes, J Hayes, S Hayes, A Hayes-Sterbenz, C A Haynam, D A Haynes, D Headley, A Heal, J E Heebner, S Heerey, G M Heestand, R Heeter, N Hein, C Heinbockel, C Hendricks, M Henesian, J Heninger, J Henrikson, E A Henry, E B Herbold, M R Hermann, G Hermes, J E Hernandez, V J Hernandez, M C Herrmann, H W Herrmann, O D Herrera, D Hewett, R Hibbard, D G Hicks, D P Higginson, D Hill, K Hill, T Hilsabeck, D E Hinkel, D D Ho, V K Ho, J K Hoffer, N M Hoffman, M Hohenberger, M Hohensee, W Hoke, D Holdener, F Holdener, J P Holder, B Holko, D Holunga, J F Holzrichter, J Honig, D Hoover, D Hopkins, L F Berzak Hopkins, M Hoppe, M L Hoppe, J Horner, R Hornung, C J Horsfield, J Horvath, D Hotaling, R House, L Howell, W W Hsing, S X Hu, H Huang, J Huckins, H Hui, K D Humbird, J Hund, J Hunt, O A Hurricane, M Hutton, K H-K Huynh, L Inandan, C Iglesias, I V Igumenshchev, I Ivanovich, N Izumi, M Jackson, J Jackson, S D Jacobs, G James, K Jancaitis, J Jarboe, L C Jarrott, D Jasion, J Jaquez, J Jeet, A E Jenei, J Jensen, J Jimenez, R Jimenez, D Jobe, Z Johal, H M Johns, D Johnson, M A Johnson, M Gatu Johnson, R J Johnson, S Johnson, S A Johnson, T Johnson, K Jones, O Jones, M Jones, R Jorge, H J Jorgenson, M Julian, B I Jun, R Jungquist, J Kaae, N Kabadi, D Kaczala, D Kalantar, K Kangas, V V Karasiev, M Karasik, V Karpenko, A Kasarky, K Kasper, R Kauffman, M I Kaufman, C Keane, L Keaty, L Kegelmeyer, P A Keiter, P A Kellett, J Kellogg, J H Kelly, S Kemic, A J Kemp, G E Kemp, G D Kerbel, D Kershaw, S M Kerr, T J Kessler, M H Key, S F Khan, H Khater, C Kiikka, J Kilkenny, Y Kim, Y-J Kim, J Kimko, M Kimmel, J M Kindel, J King, R K Kirkwood, L Klaus, D Klem, J L Kline, J Klingmann, G Kluth, P Knapp, J Knauer, J Knipping, M Knudson, D Kobs, J Koch, T Kohut, C Kong, J M Koning, P Koning, S Konior, H Kornblum, L B Kot, B Kozioziemski, M Kozlowski, P M Kozlowski, J Krammen, N S Krasheninnikova, C M Krauland, B Kraus, W Krauser, J D Kress, A L Kritcher, E Krieger, J J Kroll, W L Kruer, M K G Kruse, S Kucheyev, M Kumbera, S Kumpan, J Kunimune, E Kur, B Kustowski, T J T Kwan, G A Kyrala, S Laffite, M Lafon, K LaFortune, L Lagin, B Lahmann, B Lairson, O L Landen, T Land, M Lane, D Laney, A B Langdon, J Langenbrunner, S H Langer, A Langro, N E Lanier, T E Lanier, D Larson, B F Lasinski, D Lassle, D LaTray, G Lau, N Lau, C Laumann, A Laurence, T A Laurence, J Lawson, H P Le, R R Leach, L Leal, A Leatherland, K LeChien, B Lechleiter, A Lee, M Lee, T Lee, R J Leeper, E Lefebvre, J-P Leidinger, B LeMire, R W Lemke, N C Lemos, S Le Pape, R Lerche, S Lerner, S Letts, K Levedahl, T Lewis, C K Li, H Li, J Li, W Liao, Z M Liao, D Liedahl, J Liebman, G Lindford, E L Lindman, J D Lindl, H Loey, R A London, F Long, E N Loomis, F E Lopez, H Lopez, E Losbanos, S Loucks, R Lowe-Webb, E Lundgren, A P Ludwigsen, R Luo, J Lusk, R Lyons, T Ma, Y Macallop, M J MacDonald, B J MacGowan, J M Mack, A J Mackinnon, S A MacLaren, A G MacPhee, G R Magelssen, J Magoon, R M Malone, T Malsbury, R Managan, R Mancini, K Manes, D Maney, D Manha, O M Mannion, A M Manuel, M J-E Manuel, E Mapoles, G Mara, T Marcotte, E Marin, M M Marinak, D A Mariscal, E F Mariscal, E V Marley, J A Marozas, R Marquez, C D Marshall, F J Marshall, M Marshall, S Marshall, J Marticorena, J I Martinez, D Martinez, I Maslennikov, D Mason, R J Mason, L Masse, W Massey, P-E Masson-Laborde, N D Masters, D Mathisen, E Mathison, J Matone, M J Matthews, C Mattoon, T R Mattsson, K Matzen, C W Mauche, M Mauldin, T McAbee, M McBurney, T Mccarville, R L McCrory, A M McEvoy, C McGuffey, M Mcinnis, P McKenty, M S McKinley, J B McLeod, A McPherson, B Mcquillan, M Meamber, K D Meaney, N B Meezan, R Meissner, T A Mehlhorn, N C Mehta, J Menapace, F E Merrill, B T Merritt, E C Merritt, D D Meyerhofer, S Mezyk, R J Mich, P A Michel, D Milam, C Miller, D Miller, D S Miller, E Miller, E K Miller, J Miller, M Miller, P E Miller, T Miller, W Miller, V Miller-Kamm, M Millot, J L Milovich, P Minner, J-L Miquel, S Mitchell, K Molvig, R C Montesanti, D S Montgomery, M Monticelli, A Montoya, J D Moody, A S Moore, E Moore, M Moran, J C Moreno, K Moreno, B E Morgan, T Morrow, J W Morton, E Moses, K Moy, R Muir, M S Murillo, J E Murray, J R Murray, D H Munro, T J Murphy, F M Munteanu, J Nafziger, T Nagayama, S R Nagel, R Nast, R A Negres, A Nelson, D Nelson, J Nelson, S Nelson, S Nemethy, P Neumayer, K Newman, M Newton, H Nguyen, J-M G Di Nicola, P Di Nicola, C Niemann, A Nikroo, P M Nilson, A Nobile, V Noorai, R C Nora, M Norton, M Nostrand, V Note, S Novell, P F Nowak, A Nunez, R A Nyholm, M O'Brien, A Oceguera, J A Oertel, A L Oesterle, J Okui, B Olejniczak, J Oliveira, P Olsen, B Olson, K Olson, R E Olson, Y P Opachich, N Orsi, C D Orth, M Owen, S Padalino, E Padilla, R Paguio, S Paguio, J Paisner, S Pajoom, A Pak, S Palaniyappan, K Palma, T Pannell, F Papp, D Paras, T Parham, H-S Park, A Pasternak, S Patankar, M V Patel, P K Patel, R Patterson, S Patterson, B Paul, M Paul, E Pauli, O T Pearce, J Pearcy, A Pedretti, B Pedrotti, A Peer, L J Pelz, B Penetrante, J Penner, A Perez, L J Perkins, E Pernice, T S Perry, S Person, D Petersen, T Petersen, D L Peterson, E B Peterson, J E Peterson, J L Peterson, K Peterson, R R Peterson, R D Petrasso, F Philippe, D Phillion, T J Phipps, E Piceno, L Pickworth, Y Ping, J Pino, K Piston, R Plummer, G D Pollack, S M Pollaine, B B Pollock, D Ponce, J Ponce, J Pontelandolfo, J L Porter, J Post, O Poujade, C Powell, H Powell, G Power, M Pozulp, M Prantil, M Prasad, S Pratuch, S Price, K Primdahl, S Prisbrey, R Procassini, A Pruyne, B Pudliner, S R Qiu, K Quan, M Quinn, J Quintenz, P B Radha, F Rainer, J E Ralph, K S Raman, R Raman, P W Rambo, S Rana, A Randewich, D Rardin, M Ratledge, N Ravelo, F Ravizza, M Rayce, A Raymond, B Raymond, B Reed, C Reed, S Regan, B Reichelt, V Reis, S Reisdorf, V Rekow, B A Remington, A Rendon, W Requieron, M Rever, H Reynolds, J Reynolds, J Rhodes, M Rhodes, M C Richardson, B Rice, N G Rice, R Rieben, A Rigatti, S Riggs, H G Rinderknecht, K Ring, B Riordan, R Riquier, C Rivers, D Roberts, V Roberts, G Robertson, H F Robey, J Robles, P Rocha, G Rochau, J Rodriguez, S Rodriguez, M D Rosen, M Rosenberg, G Ross, J S Ross, P Ross, J Rouse, D Rovang, A M Rubenchik, M S Rubery, C L Ruiz, M Rushford, B Russ, J R Rygg, B S Ryujin, R A Sacks, R F Sacks, K Saito, T Salmon, J D Salmonson, J Sanchez, S Samuelson, M Sanchez, C Sangster, A Saroyan, J Sater, A Satsangi, S Sauers, R Saunders, J P Sauppe, R Sawicki, D Sayre, M Scanlan, K Schaffers, G T Schappert, S Schiaffino, D J Schlossberg, D W Schmidt, P F Schmit, J M Smidt, D H G Schneider, M B Schneider, R Schneider, M Schoff, M Schollmeier, C R Schroeder, S E Schrauth, H A Scott, I Scott, J M Scott, R H H Scott, C R Scullard, T Sedillo, F H Seguin, W Seka, J Senecal, S M Sepke, L Seppala, K Sequoia, J Severyn, J M Sevier, N Sewell, S Seznec, R C Shah, J Shamlian, D Shaughnessy, M Shaw, R Shaw, C Shearer, R Shelton, N Shen, M W Sherlock, A I Shestakov, E L Shi, S J Shin, N Shingleton, W Shmayda, M Shor, M Shoup, C Shuldberg, L Siegel, F J Silva, A N Simakov, B T Sims, D Sinars, P Singh, H Sio, K Skulina, S Skupsky, S Slutz, M Sluyter, V A Smalyuk, D Smauley, R M Smeltser, C Smith, I Smith, J Smith, L Smith, R Smith, R Smith, M Schölmerich, R Sohn, S Sommer, C Sorce, M Sorem, J M Soures, M L Spaeth, B K Spears, S Speas, D Speck, R Speck, J Spears, T Spinka, P T Springer, M Stadermann, B Stahl, J Stahoviak, J Stanley, L G Stanton, R Steele, W Steele, D Steinman, R Stemke, R Stephens, S Sterbenz, P Sterne, D Stevens, J Stevers, C H Still, C Stoeckl, W Stoeffl, J S Stolken, C Stolz, E Storm, G Stone, S Stoupin, E Stout, I Stowers, R Strauser, H Streckart, J Streit, D J Strozzi, J Stutz, L Summers, T Suratwala, G Sutcliffe, L J Suter, S B Sutton, V Svidzinski, G Swadling, W Sweet, A Szoke, M Tabak, M Takagi, A Tambazidis, V Tang, M Taranowski, L A Taylor, S Telford, W Theobald, M Thi, A Thomas, C A Thomas, I Thomas, R Thomas, I J Thompson, A Thongstisubskul, C B Thorsness, G Tietbohl, R E Tipton, M Tobin, N Tomlin, R Tommasini, A J Toreja, J Torres, R P J Town, S Townsend, J Trenholme, A Trivelpiece, C Trosseille, H Truax, D Trummer, S Trummer, T Truong, D Tubbs, E R Tubman, T Tunnell, D Turnbull, R E Turner, M Ulitsky, R Upadhye, J L Vaher, P VanArsdall, D VanBlarcom, M Vandenboomgaerde, R VanQuinlan, B M Van Wonterghem, W S Varnum, A L Velikovich, A Vella, C P Verdon, B Vermillion, S Vernon, R Vesey, J Vickers, R M Vignes, M Visosky, J Vocke, P L Volegov, S Vonhof, R Von Rotz, H X Vu, M Vu, D Wall, J Wall, R Wallace, B Wallin, D Walmer, C A Walsh, C F Walters, C Waltz, A Wan, A Wang, Y Wang, J S Wark, B E Warner, J Watson, R G Watt, P Watts, J Weaver, R P Weaver, S Weaver, C R Weber, P Weber, S V Weber, P Wegner, B Welday, L Welser-Sherrill, K Weiss, K B Wharton, G F Wheeler, W Whistler, R K White, H D Whitley, P Whitman, M E Wickett, K Widmann, C Widmayer, J Wiedwald, R Wilcox, S Wilcox, C Wild, B H Wilde, C H Wilde, K Wilhelmsen, M D Wilke, H Wilkens, P Wilkins, S C Wilks, E A Williams, G J Williams, W Williams, W H Williams, D C Wilson, B Wilson, E Wilson, R Wilson, S Winters, P J Wisoff, M Wittman, J Wolfe, A Wong, K W Wong, L Wong, N Wong, R Wood, D Woodhouse, J Woodruff, D T Woods, S Woods, B N Woodworth, E Wooten, A Wootton, K Work, J B Workman, J Wright, M Wu, C Wuest, F J Wysocki, H Xu, M Yamaguchi, B Yang, S T Yang, J Yatabe, C B Yeamans, B C Yee, S A Yi, L Yin, B Young, C S Young, C V Young, P Young, K Youngblood, J Yu, R Zacharias, G Zagaris, N Zaitseva, F Zaka, F Ze, B Zeiger, M Zika, G B Zimmerman, T Zobrist, J D Zuegel, A B Zylstra
On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven" (or G_{target}>1) where 2.05 MJ of 351 nm laser light produced 3.1 MJ of total fusion yield, a result which significantly exceeds the Lawson criterion for fusion ignition as reported in a previous NIF implosion [H. Abu-Shawareb et al. (Indirect Drive ICF Collaboration), Phys...
February 9, 2024: Physical Review Letters
https://read.qxmd.com/read/38380940/regional-practice-variation-and-outcomes-in-the-standard-versus-accelerated-initiation-of-renal-replacement-therapy-in-acute-kidney-injury-starrt-aki-trial-a-post-hoc-secondary-analysis
#7
JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
https://read.qxmd.com/read/38354629/vascular-dysfunction-and-arterial-hypertension-in-experimental-celiac-disease-are-mediated-by-gut-derived-inflammation-and-oxidative-stress
#8
JOURNAL ARTICLE
Karin Keppeler, Aline Pesi, Simon Lange, Johanna Helmstädter, Lea Strohm, Henning Ubbens, Marin Kuntić, Ivana Kuntić, Dominika Mihaliková, Ksenija Vujačić-Mirski, Alexandra Rosenberger, Leonie Küster, Charlotte Frank, Matthias Oelze, Stefanie Finger, Agnieszka Zakrzewska, Elena Verdu, Johannes Wild, Susanne Karbach, Philip Wenzel, Philipp Wild, David Leistner, Thomas Münzel, Andreas Daiber, Detlef Schuppan, Sebastian Steven
AIMS: We examined the cardiovascular effects of celiac disease (CeD) in a humanized mouse model, with a focus on vascular inflammation, endothelial dysfunction, and oxidative stress. METHODS AND RESULTS: NOD.DQ8 mice genetically predisposed to CeD were subjected to a diet regime and oral gavage to induce the disease (gluten group vs. control). We tested vascular function, confirmed disease indicators, and evaluated inflammation and oxidative stress in various tissues...
February 8, 2024: Redox Biology
https://read.qxmd.com/read/38167315/impact-of-the-practice-of-touch-massage%C3%A2-by-a-nurse-on-the-anxiety-of-patients-with-hematological-disorders-hospitalized-in-a-sterile-environment-a-randomized-controlled-study
#9
JOURNAL ARTICLE
Armelle Simon, Jean-Julien Nizard, Patrice Chevalier, Steven Le Gouill, Thomas Rulleau, Lucie Planche, Adrien Evin
CONTEXT: In addition to curative care, supportive care is beneficial in managing the anxiety symptoms common in patients in sterile hematology unit. We hypothesize that personal massage can help the patient, particularly in this isolated setting where physical contact is extremely limited. The main objective of this study was to show that anxiety could be reduced after a touch-massage® performed by a nurse trained in this therapy. METHODS: A single-center, randomized, unblinded controlled study in the sterile hematology unit of a French university hospital, validated by an ethics committee...
January 2, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38155568/rapid-anti-myeloma-activity-by-t%C3%A2-cells-expressing-an-anti-bcma-car-with-a-human-heavy-chain-only-antigen-binding-domain
#10
JOURNAL ARTICLE
Lekha Mikkilineni, Danielle A Natrakul, Norris Lam, Elisabet E Manasanch, Jennifer Mann, Katherine A Weissler, Nathan Wong, Jennifer N Brudno, Stephanie L Goff, James C Yang, Micaela Ganaden, Rashmika Patel, Zhili Zheng, Jared J Gartner, Kathryn R Martin, Hao-Wei Wang, Constance M Yuan, Tyler Lowe, Irina Maric, Lipei Shao, Ping Jin, David F Stroncek, Steven L Highfill, Steven A Rosenberg, James N Kochenderfer
Multiple myeloma (MM) is a rarely curable malignancy of plasma cells. MM expresses B cell maturation antigen (BCMA). We developed a fully human anti-BCMA chimeric antigen receptor (CAR) with a heavy-chain-only antigen-recognition domain, a 4-1BB domain, and a CD3ζ domain. The CAR was designated FHVH33-CD8BBZ. We conducted the first-in-humans clinical trial of T cells expressing FHVH33-CD8BBZ (FHVH-T). Twenty-five patients with relapsed MM were treated. The stringent complete response rate (sCR) was 52%...
December 28, 2023: Molecular Therapy
https://read.qxmd.com/read/38099402/risk-factors-and-clinical-correlates-of-sensory-dysfunction-in-preschool-children-with-and-without-autism-spectrum-disorder
#11
JOURNAL ARTICLE
Lisa D Wiggins, Katie Overwyk, Julie Daniels, Brian Barger, Hayley Crain, Rebecca Grzadzinski, Eric Moody, Ann Reynolds, Nuri Reyes, Cordelia Rosenberg, Steven Rosenberg, Karen Pazol
Sensory dysfunction is a common feature of autism spectrum disorder (ASD). The objectives of this analysis were to examine risk factors and clinical correlates of sensory dysfunction in preschool children with and without ASD. Children aged 2-5 years were enrolled in a multi-site case-control study. Data were collected in eight areas across the United States in three phases. Caregivers completed an interview with questions on assisted delivery, maternal alcohol use, maternal anxiety during pregnancy, pregnancy weight gain, neonatal jaundice, preterm birth, and child sensory diagnosis given by a healthcare provider...
December 15, 2023: Autism Research: Official Journal of the International Society for Autism Research
https://read.qxmd.com/read/38082490/the-improved-kidney-risk-score-in-anca-associated-vasculitis-for-clinical-practice-and-trials
#12
JOURNAL ARTICLE
Sebastian Bate, Dominic McGovern, Francesca Costigliolo, Pek Ghe Tan, Vojtech Kratky, Jennifer Scott, Gavin Chapman, Nina Brown, Lauren Floyd, Benoit Brilland, Eduardo Martín-Nares, Mehmet Fethullah Aydın, Duha Ilyas, Arslan Butt, Eithne Nic An Riogh, Marek Kollar, Jennifer S Lees, Abdülmecit Yıldız, Andrea Hinojosa-Azaola, Ajay Dhaygude, Stephen A Roberts, Avi Rosenberg, Thorsten Wiech, Charles D Pusey, Rachel B Jones, David Rw Jayne, Ingeborg Bajema, J Charles Jennette, Kate I Stevens, Jean Francois Augusto, Juan Manuel Mejía-Vilet, Neeraj Dhaun, Stephen McAdoo, Vladimir Tesar, Mark A Little, Geetha Duruvu, Silke R Brix
BACKGROUND: Reliable prediction tools are needed to personalize treatment in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis. A retrospective international longitudinal cohort was collated to revise the ANCA Renal Risk Score (ARRS). METHODS: The primary endpoint was end-stage kidney disease with patients censored at last follow-up. Cox Proportional Hazards were used to reweight risk factors. Kaplan-Meier curves, Harrell's C statistic, Receiver Operating Characteristics and calibration plots were used to assess model performance...
December 12, 2023: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38076887/antiviral-innate-immune-memory-in-alveolar-macrophages-following-sars-cov-2-infection
#13
Alexander Lercher, Jin-Gyu Cheong, Chenyang Jiang, Hans-Heinrich Hoffmann, Alison W Ashbrook, Yue S Yin, Corrine Quirk, Emma J DeGrace, Luis Chiriboga, Brad R Rosenberg, Steven Z Josefowicz, Charles M Rice
Pathogen encounter results in long-lasting epigenetic imprinting that shapes diseases caused by heterologous pathogens. The breadth of this innate immune memory is of particular interest in the context of respiratory pathogens with increased pandemic potential and wide-ranging impact on global health. Here, we investigated epigenetic imprinting across cell lineages in a disease relevant murine model of SARS-CoV-2 recovery. Past SARS-CoV-2 infection resulted in increased chromatin accessibility of type I interferon (IFN-I) related transcription factors in airway-resident macrophages...
November 27, 2023: bioRxiv
https://read.qxmd.com/read/38045642/accurate-repeatable-and-geometrically-precise-diffusion-weighted-imaging-on-a-0-35%C3%A2-t-magnetic-resonance-imaging-guided-linear-accelerator
#14
JOURNAL ARTICLE
Joseph Weygand, Tess Armstrong, John Michael Bryant, Jacqueline M Andreozzi, Ibrahim M Oraiqat, Steven Nichols, Casey L Liveringhouse, Kujtim Latifi, Kosj Yamoah, James R Costello, Jessica M Frakes, Eduardo G Moros, Issam M El Naqa, Arash O Naghavi, Stephen A Rosenberg, Gage Redler
BACKGROUND AND PURPOSE: Diffusion weighted imaging (DWI) allows for the interrogation of tissue cellularity, which is a surrogate for cellular proliferation. Previous attempts to incorporate DWI into the workflow of a 0.35 T MR-linac (MRL) have lacked quantitative accuracy. In this study, accuracy, repeatability, and geometric precision of apparent diffusion coefficient (ADC) maps produced using an echo planar imaging (EPI)-based DWI protocol on the MRL system is illustrated, and in vivo potential for longitudinal patient imaging is demonstrated...
October 2023: Physics and Imaging in Radiation Oncology
https://read.qxmd.com/read/38039963/phenotypic-signatures-of-circulating-neoantigen-reactive-cd8-t%C3%A2-cells-in-patients-with-metastatic-cancers
#15
JOURNAL ARTICLE
Rami Yossef, Sri Krishna, Sivasish Sindiri, Frank J Lowery, Amy R Copeland, Jared J Gartner, Maria R Parkhurst, Neilesh B Parikh, Kyle J Hitscherich, Shoshana T Levi, Praveen D Chatani, Nikolaos Zacharakis, Noam Levin, Nolan R Vale, Shirley K Nah, Aaron Dinerman, Victoria K Hill, Satyajit Ray, Alakesh Bera, Lior Levy, Li Jia, Michael C Kelly, Stephanie L Goff, Paul F Robbins, Steven A Rosenberg
Circulating T cells from peripheral blood (PBL) can provide a rich and noninvasive source for antitumor T cells. By single-cell transcriptomic profiling of 36 neoantigen-specific T cell clones from 6 metastatic cancer patients, we report the transcriptional and cell surface signatures of antitumor PBL-derived CD8+ T cells (NeoTCRPBL ). Comparison of tumor-infiltrating lymphocyte (TIL)- and PBL-neoantigen-specific T cells revealed that NeoTCRPBL T cells are low in frequency and display less-dysfunctional memory phenotypes relative to their TIL counterparts...
December 11, 2023: Cancer Cell
https://read.qxmd.com/read/37933899/radiological-density-atomic-numbers-and-stone-fragmentation-of-bego-stones-used-for-research-on-endourology-comparison-to-real-urinary-stones
#16
JOURNAL ARTICLE
Begoña Ballesta Martinez, Daniel Savio Magee, Arman Tsaturyan, Vasileios Tatanis, Angelis Peteinaris, Clare Tancabel, Matthew Chau, Steven Van der Werf, Manmeet S Saluja, Ivan Aw, Yuigi Yuminaga, Mikhail Lozinskiy, Sunny Lee, Melanie Rosenberg, Evangelos Liatsikos, Panagiotis Kallidonis
Objective: The aim of the study was to characterize artificial stones used for research in endourology in terms of radiological properties and hardness, based on stone fragmentation, and to compare them with real stones. Materials and Methods: We built artificial stones using BegoStone Plus™ powder (BEGO, Lincoln, RI), with powder (g)-water (mL) ratios ranging from 15:03 to 15:12. The CT Gemstone Spectral Imaging Software® (GE Medical Systems, LLC, Waukesha, WI) was used to evaluate the radiological density in HU and spectral properties...
January 9, 2024: Journal of Endourology
https://read.qxmd.com/read/37880931/conception-and-pregnancy-among-women-with-a-live-birth-after-breast-cancer-treatment-a-survey-study-of-young-breast-cancer-survivors
#17
JOURNAL ARTICLE
Kimia Sorouri, Tal Sella, Shoshana M Rosenberg, Maggie Loucks, Gregory Kirkner, Craig Snow, Kathryn J Ruddy, Shari I Gelber, Rulla M Tamimi, Jeffrey M Peppercorn, Lidia Schapira, Virginia F Borges, Steven E Come, Ellen Warner, Ann H Partridge
BACKGROUND: Breast cancer (BC) is the most common malignancy in women of reproductive age. This study sought to explore the postcancer conception and pregnancy experience of young BC survivors to inform counseling. METHODS: In the Young Women's Breast Cancer Study (NCT01468246), a multicenter, prospective cohort, participants diagnosed at age ≤40 years with stage 0-III BC who reported ≥1 postdiagnosis live birth were sent an investigator-developed survey...
October 25, 2023: Cancer
https://read.qxmd.com/read/37840499/multi-site-cross-site-inter-rater-and-test-retest-reliability-and-construct-validity-of-the-markvcid-white-matter-hyperintensity-growth-and-regression-protocol
#18
JOURNAL ARTICLE
Ahmed A Bahrani, Erin L Abner, Charles S DeCarli, Justin M Barber, Abigail C Sutton, Pauline Maillard, Francisco Sandoval, Konstantinos Arfanakis, Yung-Chuan Yang, Arnold M Evia, Julie A Schneider, Mohamad Habes, Crystal G Franklin, Sudha Seshadri, Claudia L Satizabal, Arvind Caprihan, Jeffrey F Thompson, Gary A Rosenberg, Danny J J Wang, Kay B Jann, Chenyang Zhao, Hanzhang Lu, Paul B Rosenberg, Marilyn S Albert, Doaa G Ali, Herpreet Singh, Kristin Schwab, Steven M Greenberg, Karl G Helmer, David K Powel, Brian T Gold, Larry B Goldstein, Donna M Wilcock, Gregory A Jicha
BACKGROUND: White matter hyperintensities (WMH) that occur in the setting of vascular cognitive impairment and dementia (VCID) may be dynamic increasing or decreasing volumes or stable over time. Quantifying such changes may prove useful as a biomarker for clinical trials designed to address vascular cognitive-impairment and dementia and Alzheimer's Disease. OBJECTIVE: Conducting multi-site cross-site inter-rater and test-retest reliability of the MarkVCID white matter hyperintensity growth and regression protocol...
October 9, 2023: Journal of Alzheimer's Disease: JAD
https://read.qxmd.com/read/37812772/the-combination-of-aroxybutynin-and-atomoxetine-in-the-treatment-of-obstructive-sleep-apnea-mariposa-a-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Paula K Schweitzer, Luigi Taranto-Montemurro, Joseph M Ojile, Stephen G Thein, Christopher L Drake, Russell Rosenberg, Bruce Corser, Brian Abaluck, R Bart Sangal, James Maynard
Rationale: Obstructive sleep apnea (OSA) is a common sleep disorder for which the principal treatment option, continuous positive airway pressure, is often poorly tolerated. There is currently no approved pharmacotherapy for OSA. However, recent studies have demonstrated improvement in OSA with combined antimuscarinic and noradrenergic drugs. Objectives: The aim of this study was to evaluate the efficacy and safety of AD109, a combination of the novel antimuscarinic agent aroxybutynin and the norepinephrine reuptake inhibitor atomoxetine, in the treatment of OSA...
December 15, 2023: American Journal of Respiratory and Critical Care Medicine
https://read.qxmd.com/read/37732975/barriers-to-referral-and-evaluation-and-corresponding-navigation-services-for-toddlers-screening-positive-for-autism-spectrum-disorder
#20
JOURNAL ARTICLE
Kristina Hightshoe, Silvia Gutiérrez-Raghunath, Margaret M Tomcho, Cordelia Robinson Rosenberg, Steven A Rosenberg, Jodi K Dooling-Litfin, Jeanette M Cordova, Kathryn Colborn, Carolyn DiGuiseppi
INTRODUCTION: Children from disadvantaged populations receive referrals, diagnoses, and services for autism spectrum disorder (ASD) late or not at all. We describe barriers to referral for and receipt of evaluation for ASD among young children from disadvantaged families and activities by autism family navigators (AFNs) to address these barriers. METHOD: Trained AFNs offered navigation to families of children aged 16-30 months with positive ASD screens from community health center clinics in 2015-2018...
September 2023: Families, Systems & Health: the Journal of Collaborative Family Healthcare
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