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Steven Rosenberg

Eliza M Park, Shari Gelber, Shoshana M Rosenberg, Davinia S E Seah, Lidia Schapira, Steven E Come, Ann H Partridge
BACKGROUND: Young adults with cancer experience disruptions in their normal developmental trajectories and commonly experience psychologic distress related to their diagnoses. Young women with metastatic breast cancer (MBC) are at particular risk of adverse mental health outcomes. OBJECTIVE: We sought to determine the prevalence of and factors associated with anxiety and depression symptoms in young women with newly diagnosed de novo MBC. METHODS: A total of 54 women with newly diagnosed de novo MBC were identified from an ongoing, prospective, multicenter cohort of women diagnosed with breast cancer at age <40...
January 31, 2018: Psychosomatics
Anne Hinks, Miranda C Marion, Joanna Cobb, Mary E Comeau, Marc Sudman, Hannah C Ainsworth, John Bowes, Mara L Becker, John F Bohnsack, Johannes-Peter Haas, Daniel J Lovell, Elizabeth D Mellins, J Lee Nelson, Ellen Nordal, Marilynn Punaro, Ann M Reed, Carlos D Rose, Alan M Rosenberg, Marite Rygg, Samantha L Smith, Anne M Stevens, Vibeke Videm, Carol A Wallace, Lucy R Wedderburn, Annie Yarwood, Rae Sm Yeung, Carl D Langefeld, Susan D Thompson, Wendy Thomson, Sampath Prahalad
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is comprised of seven heterogeneous categories of chronic childhood arthritides. About 5% of children with JIA have rheumatoid factor (RF) positive arthritis, which phenotypically resembles adult rheumatoid arthritis (RA). Our objective was to compare and contrast the genetics of RF-positive polyarticular JIA with RA, and selected other JIA categories, to more fully understand the pathophysiological relationships of inflammatory arthropathies...
February 9, 2018: Arthritis & Rheumatology
Steven A Rosenberg, Eric J Moody, Li-Ching Lee, Carolyn DiGuiseppi, Gayle C Windham, Lisa D Wiggins, Laura A Schieve, Caroline M Ledbetter, Susan E Levy, Lisa Blaskey, Lisa Young, Pilar Bernal, Cordelia R Rosenberg, M Daniele Fallin
This study examined the effect of demographic factors on Social Communication Questionnaire (SCQ) scores in children aged 30-68 months. Diagnoses of ASD were made after a gold standard evaluation that included the Autism Diagnostic Observation Schedule (ADOS), and the Autism Diagnostic Interview Revised (ADI-R). The relationship of demographic variables to SCQ scores was compared in two source populations: (a) children recruited from clinical and educational sources serving children who have ASD or other developmental disorders (CE) and (b) children recruited from birth certificates to represent the general population (BC)...
February 9, 2018: Autism Research: Official Journal of the International Society for Autism Research
Jonathan B Rosenberg, Michael Kaplitt, Bishnu P De, Alvin Chen, Thomas Flagiello, Christiana O Salami, Eduard Pey, Lingzhi Zhao, Rodolfo Ricart Arbona, Sebastien Monette, Jonathan Dyke, Douglas Ballon, Stephen M Kaminsky, Dolan Sondhi, Gregory Petsko, Steven Paul, Ronald G Crystal
Alzheimer's disease (AD) is a progressive degenerative neurological disorder affecting nearly 1 in 9 elderly people in the United States. Population studies have shown that an inheritance of the apolipoprotein E (APOE) variant APOE4 allele increases the risk of developing AD, whereas, APOE2 homozygotes are protected from late onset AD. We hypothesized that expression of the "protective" APOE2 variant by genetic modification of the central nervous system (CNS) of APOE4 homozygotes could reverse or prevent progressive neurologic damage...
February 6, 2018: Human Gene Therapy. Clinical Development
Samuel M Jenness, Kevin M Weiss, Steven M Goodreau, Thomas Gift, Harrell Chesson, Karen W Hoover, Dawn K Smith, Albert Y Liu, Patrick S Sullivan, Eli S Rosenberg
No abstract text is available yet for this article.
January 23, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Nouar Qutob, Ikuo Masuho, Michal Alon, Rafi Emmanuel, Isadora Cohen, Antonella Di Pizio, Jason Madore, Abdel Elkahloun, Tamar Ziv, Ronen Levy, Jared J Gartner, Victoria K Hill, Jimmy C Lin, Yael Hevroni, Polina Greenberg, Alexandra Brodezki, Steven A Rosenberg, Mickey Kosloff, Nicholas K Hayward, Arie Admon, Masha Y Niv, Richard A Scolyer, Kirill A Martemyanov, Yardena Samuels
Analysis of 501 melanoma exomes revealed RGS7, which encodes a GTPase-accelerating protein (GAP), to be a tumor-suppressor gene. RGS7 was mutated in 11% of melanomas and was found to harbor three recurrent mutations (p.R44C, p.E383K and p.R416Q). Structural modeling of the most common recurrent mutation of the three (p.R44C) predicted that it destabilizes the protein due to the loss of an H-bond and salt bridge network between the mutated position and the serine and aspartic acid residues at positions 58 as 61, respectively...
January 12, 2018: Scientific Reports
James A Wingrove, Karen Fitch, Brian Rhees, Steven Rosenberg, Deepak Voora
BACKGROUND: Cardiovascular disease and its sequelae are major causes of global mortality, and better methods are needed to identify patients at risk for future cardiovascular events. Gene expression analysis can inform on the molecular underpinnings of risk factors for cardiovascular events. Smoking and aspirin have known opposing effects on platelet reactivity and MACE, however their effects on each other and on MACE are not well described. METHODS: We measured peripheral blood gene expression levels of ITGA2B, which is upregulated by aspirin and correlates with platelet reactivity on aspirin, and a 5 gene validated smoking gene expression score (sGES) where higher expression correlates with smoking status, in participants from the previously reported PREDICT trial (NCT 00500617)...
January 12, 2018: BMC Medical Genomics
Shannon J Gallagher, Stephen A Rosenberg, David Francis, Shahriar Salamat, Steven P Howard, Randall J Kimple
Primary leiomyosarcoma is a rare tumor in the CNS, with few reported cases. Here, we describe a case of a primary intracranial leiomyosarcoma of the tentorium cerebelli. A 43-year-old woman presented with headache, acute vision loss, and difficulty speaking. MRI revealed a large heterogeneous-enhancing occipital mass, which was subsequently resected and diagnosed as a primary intracranial leiomyosarcoma. The patient went onto adjuvant radiotherapy delivering 60 Gy in 30 fractions. These tumors are exceedingly rare in immunocompetent individuals...
January 6, 2018: Clinical Neurology and Neurosurgery
Peter F Coccia, Alberto S Pappo, Lynda Beaupin, Virginia F Borges, Scott C Borinstein, Rashmi Chugh, Shira Dinner, Jeanelle Folbrecht, A Lindsay Frazier, Robert Goldsby, Alexandra Gubin, Robert Hayashi, Mary S Huang, Michael P Link, John A Livingston, Yousif Matloub, Frederick Millard, Kevin C Oeffinger, Diane Puccetti, Damon Reed, Steven Robinson, Abby R Rosenberg, Tara Sanft, Holly L Spraker-Perlman, Margaret von Mehren, Daniel S Wechsler, Kimberly F Whelan, Nicholas Yeager, Lisa A Gurski, Dorothy A Shead
This selection from the NCCN Guidelines for Adolescent and Young Adult (AYA) Oncology focuses on treatment and management considerations for AYA patients with cancer. Compared with older adults with cancer, AYA patients have unique needs regarding treatment, fertility counseling, psychosocial and behavioral issues, and supportive care services. The complete version of the NCCN Guidelines for AYA Oncology addresses additional aspects of caring for AYA patients, including risk factors, screening, diagnosis, and survivorship...
January 2018: Journal of the National Comprehensive Cancer Network: JNCCN
Steven M Goodreau, Deven T Hamilton, Samuel M Jenness, Patrick S Sullivan, Rachel K Valencia, Li Yan Wang, Richard L Dunville, Lisa C Barrios, Eli S Rosenberg
PURPOSE: Pre-exposure prophylaxis (PrEP) is an effective and safe intervention to prevent human immunodeficiency virus (HIV) transmission in men who have sex with men; current Centers for Disease Control and Prevention guidelines indicate its use among high-risk adults. Adolescent sexual minority males (ASMM) also have significant HIV risk, but implementation strategies are likely to differ for this population. We aimed to estimate impact and efficiency of PrEP for ASMM in higher prevalence US settings, using a variety of implementation strategies and assumptions about coverage, adherence, and background prevalence...
December 13, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
David A Drew, Allen Mo, James J Grady, Richard G Stevens, Joel B Levine, Bruce M Brenner, Joseph C Anderson, Faripour Forouhar, Michael J O'Brien, Thomas J Devers, Daniel W Rosenberg
Aberrant crypt foci (ACF) are the earliest morphologically identifiable lesion found within the human colon. Despite their relatively high frequency in the distal colon, few studies have examined the molecular characteristics of ACF within the proximal colon. In the following study, clinical participants ( n = 184) were screened for ACF using high-definition chromoendoscopy with contrast dye-spray. Following pathologic confirmation, ACF biopsies were subjected to laser capture microdissection (LCM), and epithelial cells were evaluated for somatic mutations with a customized colorectal cancer mutation panel using DNA-mass spectrometry...
March 2018: Molecular Cancer Research: MCR
Steven Maltby, Alyssa J Lochrin, Bianca Bartlett, Hock L Tay, Jessica Weaver, Ingrid J Poulton, Maximilian W Plank, Helene F Rosenberg, Natalie A Sims, Paul S Foster
A link between inflammatory disease and bone loss is now recognized. However, limited data exist on the impact of virus infection on bone loss and regeneration. Bone loss results from an imbalance in remodeling, the physiological process whereby the skeleton undergoes continual cycles of formation and resorption. The specific molecular and cellular mechanisms linking virus-induced inflammation to bone loss remain unclear. In the current study, we provide evidence that infection of mice with either lymphocytic choriomeningitis virus (LCMV) or pneumonia virus of mice (PVM) resulted in rapid and substantial loss of osteoblasts from the bone surface...
January 15, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Akash V Maharaj, Elliott W Rosenberg, Alexander T Hristov, Erez Berg, Rafael M Fernandes, Ian R Fisher, Steven A Kivelson
The paradigmatic example of a continuous quantum phase transition is the transverse field Ising ferromagnet. In contrast to classical critical systems, whose properties depend only on symmetry and the dimension of space, the nature of a quantum phase transition also depends on the dynamics. In the transverse field Ising model, the order parameter is not conserved, and increasing the transverse field enhances quantum fluctuations until they become strong enough to restore the symmetry of the ground state. Ising pseudospins can represent the order parameter of any system with a twofold degenerate broken-symmetry phase, including electronic nematic order associated with spontaneous point-group symmetry breaking...
December 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
Ryan A Denu, Stephen A Rosenberg, Steven P Howard
Background: Trigeminal neuralgia (TN) is a chronic pain condition characterized by brief episodes of lancinating pain in one or more distributions of the trigeminal nerve. Episodes of pain secondary to TN are triggered by certain stimuli, such as chewing, shaving, or touching the face. Although a common cause of TN is compression of the trigeminal nerve root entry zone by an artery or vein, many cases of TN are idiopathic. However, there have been limited reports in the literature of familial TN...
June 2017: Journal of Radiation Oncology
Rand Arafeh, Karen Flores, Alona Keren-Paz, Galia Maik-Rachline, Naomi Gutkind, Steven Rosenberg, Rony Seger, Yardena Samuels
Genetic alterations in BRAF, NRAS and NF1 that activate the ERK cascade, account for over 80% of metastatic melanomas. However, ERK cascade inhibitors have been proven beneficial almost exclusively for BRAF mutant melanomas. One of the hallmarks of the ERK cascade is the nuclear translocation of ERK1/2, which is important mainly for the induction of proliferation. This translocation can be inhibited by the NTS-derived peptide (EPE) that blocks the ERK1/2-importin7 interaction, inhibits the nuclear translocation of ERK1/2, and arrests active ERK1/2 in the cytoplasm...
November 27, 2017: Scientific Reports
Yong-Chen Lu, Zhili Zheng, Paul F Robbins, Eric Tran, Todd D Prickett, Jared J Gartner, Yong F Li, Satyajit Ray, Zulmarie Franco, Valery Bliskovsky, Peter C Fitzgerald, Steven A Rosenberg
The adoptive transfer of neoantigen-reactive tumor-infiltrating lymphocytes (TILs) can result in tumor regression in patients with metastatic cancer. To improve the efficacy of adoptive T cell therapy targeting these tumor-specific mutations, we have proposed a new therapeutic strategy, which involves the genetic modification of autologous T cells with neoantigen-specific T cell receptors (TCRs) and the transfer of these modified T cells back to cancer patients. However, the current techniques to isolate neoantigen-specific TCRs are labor intensive, time consuming, and technically challenging, not suitable for clinical applications...
February 7, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
Krista L Lanctôt, Joan Amatniek, Sonia Ancoli-Israel, Steven E Arnold, Clive Ballard, Jiska Cohen-Mansfield, Zahinoor Ismail, Constantine Lyketsos, David S Miller, Erik Musiek, Ricardo S Osorio, Paul B Rosenberg, Andrew Satlin, David Steffens, Pierre Tariot, Lisa J Bain, Maria C Carrillo, James A Hendrix, Heidi Jurgens, Brendon Boot
Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing substantial distress for both people with dementia and their caregivers, and contributing to early institutionalization. They are among the earliest signs and symptoms of neurocognitive disorders and incipient cognitive decline, yet are under-recognized and often challenging to treat. With this in mind, the Alzheimer's Association convened a Research Roundtable in May 2016, bringing together experts from academia, industry, and regulatory agencies to discuss the latest understanding of NPSs and review the development of therapeutics and biomarkers of NPSs in AD...
September 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
Katherine R Adams, Sitara Chauhan, Divya B Patel, Virginia K Clements, Yan Wang, Steven M Jay, Nathan J Edwards, Suzanne Ostrand-Rosenberg, Catherine Fenselau
Ubiquitinated proteins carried by the extracellular vesicles (EV) released by myeloid-derived suppressor cells (MDSC) have been investigated using proteomic strategies to examine the effect of tumor-associated inflammation. EV were collected from MDSC directly following isolation from tumor-bearing mice with low and high inflammation. Among the 1092 proteins (high inflammation) and 925 proteins (low inflammation) identified, more than 50% were observed as ubiquitinated proteoforms. More than three ubiquitin-attachment sites were characterized per ubiquitinated protein, on average...
November 10, 2017: Journal of Proteome Research
Carolyn DiGuiseppi, Susan E Levy, Katherine R Sabourin, Gnakub N Soke, Steven Rosenberg, Li-Ching Lee, Eric Moody, Laura A Schieve
This study examined caregiver-reported medically-attended injuries among 30-68 month old children with autism spectrum disorder (ASD) compared to general population (POP) and non-ASD developmental disorders (DD) controls in the Study to Explore Early Development. Injuries were common in ASD cases (32.3%) as well as POP (30.2%) and DD (27.8%) controls; most resulted in an emergency visit or hospitalization. After accounting for sociodemographic, health, IQ and behavior differences, odds of injury in ASD cases were significantly higher than DD controls but similar to POP controls...
October 11, 2017: Journal of Autism and Developmental Disorders
Jocelyn Gomez, Hunter G Hoffman, Steven L Bistricky, Miriam Gonzalez, Laura Rosenberg, Mariana Sampaio, Azucena Garcia-Palacios, Maria V Navarro-Haro, Wadee Alhalabi, Marta Rosenberg, Walter J Meyer, Marsha M Linehan
Sustaining a burn injury increases an individual's risk of developing psychological problems such as generalized anxiety, negative emotions, depression, acute stress disorder, or post-traumatic stress disorder. Despite the growing use of Dialectical Behavioral Therapy® (DBT®) by clinical psychologists, to date, there are no published studies using standard DBT® or DBT® skills learning for severe burn patients. The current study explored the feasibility and clinical potential of using Immersive Virtual Reality (VR) enhanced DBT® mindfulness skills training to reduce negative emotions and increase positive emotions of a patient with severe burn injuries...
2017: Frontiers in Psychology
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