Thomas W Battaglia, Iris L Mimpen, Joleen J H Traets, Arne van Hoeck, Laurien J Zeverijn, Birgit S Geurts, Gijs F de Wit, Michaël Noë, Ingrid Hofland, Joris L Vos, Sten Cornelissen, Maartje Alkemade, Annegien Broeks, Charlotte L Zuur, Edwin Cuppen, Lodewyk Wessels, Joris van de Haar, Emile Voest
Microbial communities are resident to multiple niches of the human body and are important modulators of the host immune system and responses to anticancer therapies. Recent studies have shown that complex microbial communities are present within primary tumors. To investigate the presence and relevance of the microbiome in metastases, we integrated mapping and assembly-based metagenomics, genomics, transcriptomics, and clinical data of 4,160 metastatic tumor biopsies. We identified organ-specific tropisms of microbes, enrichments of anaerobic bacteria in hypoxic tumors, associations between microbial diversity and tumor-infiltrating neutrophils, and the association of Fusobacterium with resistance to immune checkpoint blockade (ICB) in lung cancer...
April 5, 2024: Cell