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https://www.readbyqxmd.com/read/29237452/molecular-cloning-and-characterization-of-the-family-of-feline-leucine-rich-glioma-inactivated-lgi-genes-and-mutational-analysis-in-familial-spontaneous-epileptic-cats
#1
Yoshihiko Yu, Daisuke Hasegawa, Aki Fujiwara-Igarashi, Yuji Hamamoto, Shunta Mizoguchi, Takayuki Kuwabara, Michio Fujita
BACKGROUND: Leucine-rich glioma-inactivated (LGI) proteins play a critical role in synaptic transmission. Dysfunction of these genes and encoded proteins is associated with neurological disorders such as genetic epilepsy or autoimmune limbic encephalitis in animals and human. Familial spontaneous epileptic cats (FSECs) are the only feline strain and animal model of familial temporal lobe epilepsy. The seizure semiology of FSECs comprises recurrent limbic seizures with or without evolution into generalized epileptic seizures, while cats with antibodies against voltage-gated potassium channel complexed/LGI1 show limbic encephalitis and recurrent limbic seizures...
December 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29232654/cxcl12-cxcr4-axis-in-feline-mammary-carcinoma
#2
Fernando Ferreira
No abstract text is available yet for this article.
December 11, 2017: Aging
https://www.readbyqxmd.com/read/29230821/tibial-plateau-levelling-osteotomy-locking-compression-plates-for-stabilisation-of-canine-and-feline-ilial-body-fractures
#3
J W Guthrie, S Kalff
OBJECTIVES: To evaluate the clinical and radiographic outcomes following surgical stabilisation of ilial fractures in dogs and cats using a laterally applied Synthes TPLO locking compression plate. MATERIALS AND METHODS: Medical records and radiographs of seven dogs and two cats which had undergone surgical repair of an ilial body fracture with a TPLO locking compression plate were reviewed. Long-term clinical follow-up was obtained from an owner or referring veterinarian questionnaire...
December 12, 2017: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29228796/component-resolved-microarray-analysis-of-ige-sensitization-profiles-to-felis-catus-major-allergen-molecules-in-russian-cat-allergic-patients
#4
Anna Sergeevna Dolgova, Anna Evgenevna Sudina, Anna Sergeevna Cherkashina, Olga Alekseevna Stukolova
We aimed to determine the profile of IgE reactivity to three major cat allergens, Fel d 1, Fel d 2 and Fel d 4, in cat-allergic patients in the Moscow region in Russia. sIgE levels to recombinant proteins expressed in Escherichia coli (Fel d 1 and Fel d 4) and to Fel d 2 protein purified from cat serum were measured using a microarray method developed in our laboratory. Sera from 174 anonymous subjects with a positive reaction (≥0.35 IU/mL) to cat dander extract (e1, ImmunoCAP) and 56 negative controls were used for IgE testing...
December 11, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29227138/a-comparison-of-mycotoxin-contamination-of-premium-and-grocery-brands-of-pelleted-cat-food-in-south-africa
#5
Sanil D Singh, Sooraj Baijnath, Anil A Chuturgoon
Contamination with mycotoxins is of concern to pet owners and veterinary practitioners owing to their ability to cause disease and exacerbate the pathological changes associated with other diseases. Currently, there is a lack of information regarding the mycotoxin content of common premium brand (PB) and grocery brand (GB) cat feeds. Therefore, we undertook to determine the mycobiota content of feed samples, from both categories (n = 6 each), and measured the levels of aflatoxin (AF), fumonisin (FB), ochratoxin A (OTA) and zearalenone (ZEA) by high performance liquid chromatographic analysis...
November 22, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29224180/evaluation-of-a-rapid-immunochromatographic-test-for-the-detection-of-low-burden-dirofilaria-immitis-heartworm-in-dogs-and-cats
#6
REVIEW
Marco Genchi, Carlo Mangia, Nicola Ferrari, Sofia Loukeri
The performance of a rapid immunochromatographic test for the detection of Dirofilaria immitis antigens (Speed Diro™; BVT-Virbac, France) was assessed in 49 experimentally infected dogs and in 244 naturally infected animals; 142 dogs and 102 cats. In experimentally infected dogs, Speed Diro™ showed a sensitivity of 90.9% in dogs infected with one adult female worm and 100% in dogs infected with more than one female worm. Specificity was 100%. For naturally infected dogs, the Knott test and PetChek® HTWM PF served as reference methods for microfilaremia and antigenemia, respectively...
December 9, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29220723/gold-nanoparticles-enhance-radiation-sensitization-and-suppress-colony-formation-in-a-feline-injection-site-sarcoma-cell-line-in-vitro
#7
J Z Benton, R J Williams, A Patel, K Meichner, J Tarigo, K Nagata, T D Pethel, R M Gogal
Injection Site Sarcomas (ISS) are highly invasive feline malignant tumors that are frequently associated with routine vaccination. Current treatment modalities include chemotherapy, radiation, and radical surgery. ISS have been shown to be one of the most treatment resistant of feline cancers with high rates of recurrence. Previous studies have shown that gold and other high atomic number nanoparticles have the ability to increase the dose of radiation deposited into tissue by generating secondary electrons...
December 2, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29220333/feline-transdermal-formulation-considerations
#8
Lauren Eichstadt Forsythe
Transdermal delivery of drugs is comparatively new in feline patients. However, transdermal formulations can be a desirable option for treating feline patients that are not willing participants to medication administration. However, achieving drug penetration across the skin is not always easy, and there are a wide variety of variables that can further affect penetration. This, coupled with a lack of studies, make transdermal administration an unknown with regards to efficacy and safety for many drugs. This article focuses on drugs that are administered transdermally with the intent of producing systemic effects...
November 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29219213/effect-of-a-pheromone-on-stress-associated-reactivation-of-feline-herpesvirus-1-in-experimentally-inoculated-kittens
#9
Elena T Contreras, E Hodgkins, V Tynes, A Beck, F Olea-Popelka, M R Lappin
BACKGROUND: Stress contributes to reactivation of feline herpesvirus-1 (FHV-1). The usage of pheromones to decrease stress in FHV-1 experimentally inoculated kittens has not previously been investigated. HYPOTHESIS/OBJECTIVES: To determine whether a feline pheromone would lessen stress, resulting in decreased recurrence of FHV-1-associated illness in kittens. ANIMALS: Twelve 5-month-old, purpose-bred kittens. METHODS: Randomized, double-blind, placebo-controlled clinical trial...
December 8, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29217316/prevention-of-feline-injection-site-sarcomas-is-there-a-scientific-foundation-for-vaccine-recommendations-at-this-time
#10
REVIEW
Philip H Kass
Recently published guidelines have made specific vaccine recommendations purported to potentially reduce the incidence of feline injection-site sarcomas (FISS). These recommendations have largely been based on experimental models of inflammation under different vaccine formulations. In none of these studies did sarcomas occur. It is scientifically untenable to address FISS risk based on propensity of vaccines to elicit differential inflammatory responses if none of those responses led to sarcoma development...
December 4, 2017: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29215022/mineral-analysis-of-complete-dog-and-cat-foods-in-the-uk-and-compliance-with-european-guidelines
#11
M Davies, R Alborough, L Jones, C Davis, C Williams, D S Gardner
Mineral content of complete pet food is regulated to ensure health of the companion animal population. Analysis of adherence to these regulatory guidelines has not been conducted. Here, mineral composition of complete wet (n = 97) and dry (n = 80) canine and feline pet food sold in the UK was measured to assess compliance with EU guidelines. A majority of foods complied with ≥8 of 11 guidelines (99% and 83% for dry and wet food, respectively), but many failed to provide nutritional minimum (e.g. Cu, 20% of wet food) or exceeded nutritional maximum (e...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29212585/clinical-salmonellosis-in-a-closed-colony-of-blood-donor-cats
#12
Amie Koenig, Tanya L Cooper, Craig E Greene, Ajay Sharma, Kaori Sakamoto
An adult feline blood donor, group-housed in a closed colony with other blood donor cats in a laboratory animal facility, developed anorexia, abdominal pain, an abdominal mass effect, and hemorrhagic diarrhea. Ultimately Salmonella infection was diagnosed. The index cat and 2 additional cats in the closed colony had clinical signs consistent with Salmonella and yielded Salmonella serotype 4,12:i:- in fecal cultures. An extensive search for the source of Salmonella was unrewarding. With the implementation of individual housing and additional barrier precautions, combined with antibiotic treatment of the index case, all the cats survived and subsequently had multiple, negative Salmonella PCR test results...
December 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/29208009/troglostrongylus-brevior-a-new-parasite-for-romania
#13
Georgiana Deak, Angela Monica Ionică, Andrei Daniel Mihalca, Călin Mircea Gherman
BACKGROUND: The genus Troglostrongylus includes nematodes infecting domestic and wild felids. Troglostrongylus brevior was described six decades ago in Palestine and subsequently reported in some European countries (Italy, Spain, Greece, Bulgaria, and Bosnia and Herzegovina). As the diagnosis by the first-stage larvae (L1) may be challenging, there is a possibility of confusion with Aelurostrongylus abstrusus. Hence, the knowledge on the distribution of this neglected feline parasite is still scarce...
December 6, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29202674/determination-of-the-diversity-of-astroviruses-in-feces-from-cats-in-florida
#14
Patricia E Lawler, Kirstin A Cook, Hannah G Williams, Linda L Archer, Karen E Schaedel, Natalie M Isaza, James F X Wellehan
Astroviruses are small, nonenveloped RNA viruses that have been linked to numerous diseases in a variety of species, including enteric disease in humans and cheetahs. Species Mamastrovirus 2, previously known as feline astrovirus, has been isolated from the feces of domestic cats and cheetahs. A total of 122 cat fecal samples from Alachua County, FL Animal Services and the Veterinary Community Outreach Program at the University of Florida were analyzed, and 35 contained astroviral RNA that was amplified and identified using consensus RT-PCR and sequence analysis...
December 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29199213/variation-of-amino-acid-sequences-of-serum-amyloid-a-saa-and-immunohistochemical-analysis-of-amyloid-a-aa-in-japanese-domestic-cats
#15
Meina Tei, Kazuyuki Uchida, James K Chambers, Ken-Ichi Watanabe, Takashi Tamamoto, Koichi Ohno, Hiroyuki Nakayama
Amyloid A (AA) amyloidosis, a fatal systemic amyloid disease, occurs secondary to chronic inflammatory conditions in humans. Although persistently elevated serum amyloid A (SAA) levels are required for its pathogenesis, not all individuals with chronic inflammation necessarily develop AA amyloidosis. Furthermore, many diseases in cats are associated with the elevated production of SAA, whereas only a small number actually develop AA amyloidosis. We hypothesized that a genetic mutation in the SAA gene may strongly contribute to the pathogenesis of feline AA amyloidosis...
December 4, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29197389/foamy-virus-zoonotic-infections
#16
Delia M Pinto-Santini, Carolyn R Stenbak, Maxine L Linial
BACKGROUND: Foamy viruses (FV) are ancient complex retroviruses that differ from orthoretroviruses such as human immunodeficiency virus (HIV) and murine leukemia virus (MLV) and comprise a distinct subfamily of retroviruses, the Spumaretrovirinae. FV are ubiquitous in their natural hosts, which include cows, cats, and nonhuman primates (NHP). FV are transmitted mainly through saliva and appear nonpathogenic by themselves, but they may increase morbidity of other pathogens in coinfections...
December 2, 2017: Retrovirology
https://www.readbyqxmd.com/read/29193526/triple-phase-computed-tomography-of-the-pancreas-in-healthy-cats
#17
Scott Secrest, Ajay Sharma, Andrew Bugbee
While the availability and use of computed tomography (CT) continues to grow, no study has described the size and multiphase CT appearance of the normal feline pancreas. This information is important to not only allow more accurate identification and differentiation of disease, but it may also be useful in assessing pancreatic function. In this prospective analytical study, we described a triple phase CT protocol of the pancreas for use in sedated cats and the attenuation, enhancement pattern, size, and volume of the pancreas for a group of healthy cats...
November 28, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29192808/a-splice-site-variant-in-flvcr1-produces-retinitis-pigmentosa-without-posterior-column-ataxia
#18
Imran H Yusuf, Morag E Shanks, Penny Clouston, Robert E MacLaren
FLVCR1 (feline leukemia virus subgroup c receptor 1) is a transmembrane protein involved in the trafficking of intracellular heme. Homozygous variants in FLVCR1 have been described in association with a clinical syndrome of posterior column ataxia with retinitis pigmentosa (PCARP). Here, we describe a patient with non-syndromic retinitis pigmentosa homozygous for a splice-site variant in FLVCR1 (c.1092 + 5G>A) without evidence of posterior column ataxia or cerebellar degeneration. We suggest an association between intronic splice-site variants in FLVCR1 and the absence of posterior column degeneration and suggest a hypothesis to explain this observation...
December 1, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29188759/identifying-free-text-features-to-improve-automated-classification-of-structured-histopathology-reports-for-feline-small-intestinal-disease
#19
Abdullah Awaysheh, Jeffrey Wilcke, François Elvinger, Loren Rees, Weiguo Fan, Kurt Zimmerman
The histologic evaluation of gastrointestinal (GI) biopsies is the standard for diagnosis of a variety of GI diseases (e.g., inflammatory bowel disease [IBD] and alimentary lymphoma [ALA]). The World Small Animal Veterinary Association (WSAVA) Gastrointestinal International Standardization Group proposed a reporting standard for GI biopsies consisting of a defined set of microscopic features. We compared the machine classification accuracy of free-text microscopic findings with those represented in the WSAVA format with a diagnosis of IBD and ALA...
November 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/29187719/-small-animal-aspergillosis-and-cryptococcosis-in-japan
#20
Rui Kano
 Canine and feline upper respiratory tract (URT) infection due to Aspergillus spp. is considered an emerging disease, with the number of reported cases continuing to rise in Japan. Aspergillus fumigatus has been the most frequently reported etiologic agent of sino-orbital aspergillosis in dogs and cats; the other Aspergillus species, Aspergillus felis, Aspergillus fischeri, Aspergillus udagawae, Aspergillus viridinutans, and A. fumigatus, have also been implicated in feline cases. The minimum inhibitory concentrations (MICs) of antifungal drugs are elevated for these cryptic species compared with A...
2017: Medical Mycology Journal
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