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Carl June

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https://www.readbyqxmd.com/read/27906924/reducing-harm-from-falls
#1
Shelley Jones, Sandy Blake, Richard Hamblin, Carmela Petagna, Carl Shuker, Alan F Merry
Serious adverse event reporting from district health boards (DHBs) brought in-hospital falls to the attention of the Health Quality & Safety Commission (the Commission) when it was incepted in 2010. In 2012, responding to the large numbers reported, the Commission began planning for a three-year programme to reduce harm from falls, initially to run 2013-2015. In this article we discuss the serious consequences of falls, and the challenges and practical considerations involved in reducing the risk of falling and the rate of falls...
December 2, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27887864/optimization-of-cgmp-purification-and-expansion-of-umbilical-cord-blood-derived-t-regulatory-cells-in-support-of-first-in-human-clinical-trials
#2
David H McKenna, Darin Sumstad, Diane M Kadidlo, Bjorn Batdorf, Colin J Lord, Sarah C Merkel, Christine M Koellner, Julie M Curtsinger, Carl H June, James L Riley, Bruce L Levine, Jeffrey S Miller, Claudio G Brunstein, John E Wagner, Bruce R Blazar, Keli L Hippen
BACKGROUND AIMS: Thymic-derived regulatory T cells (tTreg) are critical regulators of the immune system. Adoptive tTreg transfer is a curative therapy for murine models of autoimmunity, graft rejection, and graft-versus-host disease (GVHD). We previously completed a "first-in-human" clinical trial using in vitro expanded umbilical cord blood (UCB)-derived tTreg to prevent GVHD in patients undergoing UCB hematopoietic stem cell transplantation (HSCT). tTreg were safe and demonstrated clinical efficacy, but low yield prevented further dose escalation...
November 22, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27855210/potent-and-broad-inhibition-of-hiv-1-by-a-peptide-from-the-gp41-heptad-repeat-2-domain-conjugated-to-the-cxcr4-amino-terminus
#3
George J Leslie, Jianbin Wang, Max W Richardson, Beth S Haggarty, Kevin L Hua, Jennifer Duong, Anthony J Secreto, Andrea P O Jordon, Josephine Romano, Kritika E Kumar, Joshua J DeClercq, Philip D Gregory, Carl H June, Michael J Root, James L Riley, Michael C Holmes, James A Hoxie
HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and over-expressed on the cell surface. We hypothesized that potent anti-HIV activity could be achieved if a 34 amino acid peptide from HR2 (C34) were brought to the site of virus-cell interactions by conjugation to the amino termini of HIV-1 coreceptors CCR5 or CXCR4...
November 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27852399/-analysis-of-the-influence-factors-of-school-age-children-s-refractive-status
#4
Z G Chen, M C Chen, J Y Zhang, D Q Cai, Q Wang, S S Lin, J W Chen, H L Zhong
Objective: To analyze the influence of the eye biological parameters, height, and weight on the school-age children's refractive status. Methods: Cross-sectional study. A total of 1 656 children (1 656 eyes), aged from 7 to 14 years, were selected from 8 schools in Wenzhou during June 2012 and June 2013. The height and weight of each child were measured, and the body mass index (BMI) was calculated. The eye biological parameters, including axial length (AL), corneal power (C=1/CR), anterior chamber depth (ACD), and white to white (WTW), were measured by IOLMaster (version 5...
November 11, 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27826709/risk-factors-for-cardiac-arrest-or-mechanical-circulatory-support-in-children-with-fulminant-myocarditis
#5
Joseph R Casadonte, Mjaye L Mazwi, Katheryn E Gambetta, Hannah L Palac, Mary E McBride, Osama M Eltayeb, Michael C Monge, Carl L Backer, John M Costello
In children with fulminant myocarditis (FM), we sought to describe presenting characteristics and clinical outcomes, and identify risk factors for cardiac arrest and mechanical circulatory support (MCS). A retrospective review of patients with FM admitted at our institution between January 1, 2004, and June 31, 2015, was performed. We compared characteristics and outcomes of FM patients who received cardiopulmonary resuscitation (CPR) and/or were placed on MCS (CPR/MCS group) to those who did not develop these outcomes (Control group)...
November 8, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27815355/multiplex-genome-editing-to-generate-universal-car-t-cells-resistant-to-pd1-inhibition
#6
Jiangtao Ren, Xiaojun Liu, Chongyun Fang, Shuguang Jiang, Carl H June, Yangbing Zhao
PURPOSE: Using gene-disrupted allogeneic T cells as universal effector cells provides an alternative to and potentially improves current chimeric antigen receptor (CAR) T cell therapy against cancers and infectious diseases. EXPERIMENTAL DESIGN: The CRISPR/Cas9 system has recently emerged as a simple and efficient way for multiplex genome engineering. By combining the lentiviral delivery of CAR and CRISPR RNA electroporation to co-introduce RNA encoding the Cas9 and gRNAs targeting endogenous TCR, beta-2 microglobulin (B2M) and PD1 simultaneously, to generate gene-disrupted allogeneic CAR T cells deficient of TCR, HLA class I molecule and PD1...
November 4, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27794547/national-and-northern-new-england-opioid-prescribing-patterns-2013-2014
#7
Adam R Toth, Carl J Possidente, Linda M Sawyer, Mark A DiParlo, Gilbert J Fanciullo
: OBJECTIVE : To evaluate current opioid prescribing patterns nationally and regionally across several northern New England states and compare with prescription data on an institutional level over a two-year period, between 2013 and 2014. DESIGN, SETTING, AND SUBJECTS:  The IMS Health National Prescription Audit (NPA) database was used to obtain prescription data from US retail pharmacies between 2013 and 2014. METHODS:  Our study compared noninjectable opioid dispensing between two time periods: January-June 2013 and July-December 2014...
October 29, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/27745631/evaluating-the-skin-in-patients-undergoing-chimeric-antigen-receptor-modified-t-cell-therapy
#8
Courtney B Rubin, Rosalie Elenitsas, Laura Taylor, Simon F Lacey, Irina Kulikovskaya, Minnal Gupta, Jan J Melenhorst, Alison Loren, Noelle Frey, Carl H June, David Porter, Misha Rosenbach
No abstract text is available yet for this article.
November 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27692110/necrotising-fasciitis-of-the-extremities-implementation-of-new-management-technologies
#9
Pablo S Corona, Frank Erimeiku, Maria Mercedes Reverté-Vinaixa, Francisco Soldado, Carles Amat, Lluis Carrera
INTRODUCTION: Necrotising fasciitis (NF) is potentially life-threatening soft-tissue infection. Early diagnosis and aggressive surgical debridement are critical to decrease mortality and morbidity. The impacts of new management technologies such as hydro-bisturi-assisted debridement (HAD) and negative pressure wound therapy (NPWT) are not yet clear with respect to treatment of NF. The objective of this study was to describe laboratory (including LRINEC score), clinical and microbiological factors, treatment methods and outcomes related to managing necrotising fasciitis, focusing on the implementation of new treatment methods in our centre...
September 2016: Injury
https://www.readbyqxmd.com/read/27668293/a-cure-for-hiv-infection-not-in-my-lifetime-or-just-around-the-corner
#10
Michael M Lederman, Paula M Cannon, Judith S Currier, Carl H June, Hans Peter Kiem, Daniel R Kuritzkes, Sharon R Lewin, David M Margolis, Joseph M McCune, John W Mellors, Timothy W Schacker, Rafick P Sekaly, Pablo Tebas, Bruce D Walker, Daniel C Douek
With the advent and stunning success of combination antiretroviral therapy (ART) to prolong and improve quality of life for persons with HIV infection, HIV research has been afforded the opportunity to pivot towards studies aimed at finding "a cure." The mere idea that cure of HIV might be possible has energized researchers and the community towards achieving this goal. Funding agencies, both governmental and private, have targeted HIV cure as a high priority; many in the field have responded to these initiatives and the cure research agenda is robust...
2016: Pathogens & Immunity
https://www.readbyqxmd.com/read/27632680/cytokine-release-syndrome-after-chimeric-antigen-receptor-t-cell-therapy-for-acute-lymphoblastic-leukemia
#11
Julie C Fitzgerald, Scott L Weiss, Shannon L Maude, David M Barrett, Simon F Lacey, J Joseph Melenhorst, Pamela Shaw, Robert A Berg, Carl H June, David L Porter, Noelle V Frey, Stephan A Grupp, David T Teachey
OBJECTIVE: Initial success with chimeric antigen receptor-modified T cell therapy for relapsed/refractory acute lymphoblastic leukemia is leading to expanded use through multicenter trials. Cytokine release syndrome, the most severe toxicity, presents a novel critical illness syndrome with limited data regarding diagnosis, prognosis, and therapy. We sought to characterize the timing, severity, and intensive care management of cytokine release syndrome after chimeric antigen receptor-modified T cell therapy...
September 14, 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27612286/the-cytological-features-of-car-t-cells
#12
Sarah Brooks, Noelle Frey, David Porter, Carl June, Simon Lacey, Adam Bagg
No abstract text is available yet for this article.
September 9, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27584485/peripheral-qct-sector-analysis-reveals-positive-bone-adaptations-following-osteogenic-index-optimized-exercise-2874-board-6-june-3-1-00-pm-3-00-pm
#13
Joseph R Pierce, Kathleen N Beasley, Amanda J Centi, Dennis E Scofield, Charles H Negus, Rachel K Evans, Carl M Maresh, William J Kraemer, Bradley C Nindl
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27584444/3-months-of-nitrate-plus-exercise-training-increases-performance-more-than-training-alone-in-peripheral-arterial-disease-2409-board-7-june-3-9-30-am-11-30-am
#14
Jason David Allen, Mary N Woessner, Mitch VanBruggen, Thomas Stabler, Johanna L Johnson, Carl Pieper, William E Kraus
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27584443/3-months-of-nitrate-plus-exercise-training-improves-hemodynamic-profile-in-peripheral-arterial-disease-2408-board-6-june-3-9-30-am-11-30-am
#15
Cassandra Smith, Mary N Woessner, Mitch VanBruggen, Thomas Stabler, Johanna L Johnson, Carl Pieper, William E Kraus, Jason D Allen
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27571406/dual-cd19-and-cd123-targeting-prevents-antigen-loss-relapses-after-cd19-directed-immunotherapies
#16
Marco Ruella, David M Barrett, Saad S Kenderian, Olga Shestova, Ted J Hofmann, Jessica Perazzelli, Michael Klichinsky, Vania Aikawa, Farzana Nazimuddin, Miroslaw Kozlowski, John Scholler, Simon F Lacey, Jan J Melenhorst, Jennifer J D Morrissette, David A Christian, Christopher A Hunter, Michael Kalos, David L Porter, Carl H June, Stephan A Grupp, Saar Gill
Potent CD19-directed immunotherapies, such as chimeric antigen receptor T cells (CART) and blinatumomab, have drastically changed the outcome of patients with relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL). However, CD19-negative relapses have emerged as a major problem that is observed in approximately 30% of treated patients. Developing approaches to preventing and treating antigen-loss escapes would therefore represent a vertical advance in the field. Here, we found that in primary patient samples, the IL-3 receptor α chain CD123 was highly expressed on leukemia-initiating cells and CD19-negative blasts in bulk B-ALL at baseline and at relapse after CART19 administration...
October 3, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27550819/engineered-t-cells-the-promise-and-challenges-of-cancer-immunotherapy
#17
Andrew D Fesnak, Carl H June, Bruce L Levine
The immune system evolved to distinguish non-self from self to protect the organism. As cancer is derived from our own cells, immune responses to dysregulated cell growth present a unique challenge. This is compounded by mechanisms of immune evasion and immunosuppression that develop in the tumour microenvironment. The modern genetic toolbox enables the adoptive transfer of engineered T cells to create enhanced anticancer immune functions where natural cancer-specific immune responses have failed. Genetically engineered T cells, so-called 'living drugs', represent a new paradigm in anticancer therapy...
August 23, 2016: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/27531112/-analysis-of-myopia-and-axial-length-changes-and-relevant-factors-of-children-aged-7-to-14-years-in-wenzhou
#18
J Y Zhang, Q Wang, S S Lin, J W Chen, H L Zhong, D Q Ca, Z G Chen
OBJECTIVE: To investigate the incidence and features of myopia in children aged 7 to 14 years. METHODS: Cross-sectional study. A total of 2 226 children (2 226 eyes) aged 7 to 14 years were selected from school during June 2012 and January 2015. Refraction was measured by fast cycloplegic retinoscopy. SPSS16.0 was used to analyze the data. Ocular refractive parameters, including axial length (AL), corneal power, anterior chamber depth, and white to white, were measured by IOLMaster (version 5...
July 2016: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/27506378/rethinking-the-regulatory-infrastructure-for-human-gene-transfer-clinical-trials
#19
Christopher L Jenkins, Mark L Bagarazzi, Hans-Peter Kiem, Arnold J Levine, Dale Ando, Carl H June, Tony Reid, David W Emery
No abstract text is available yet for this article.
August 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/27494429/interventions-for-compassionate-nursing-care-a-systematic-review
#20
REVIEW
Karin Blomberg, Peter Griffiths, Yvonne Wengström, Carl May, Jackie Bridges
BACKGROUND: Compassion has been identified as an essential element of nursing and is increasingly under public scrutiny in the context of demands for high quality health care. While primary research on effectiveness of interventions to support compassionate nursing care has been reported, no rigorous critical overview exists. OBJECTIVES: To systematically identify, describe and analyse research studies that evaluate interventions for compassionate nursing care; assess the descriptions of the interventions for compassionate care, including design and delivery of the intervention and theoretical framework; and to evaluate evidence for the effectiveness of interventions...
October 2016: International Journal of Nursing Studies
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