keyword
https://read.qxmd.com/read/38521901/in-vivo-antimalarial-effect-of-1-hydroxy-5-6-7-trimethoxyxanthone-isolated-from-mammea-siamensis-t-anders-flowers-pharmacokinetic-and-acute-toxicity-studies
#21
JOURNAL ARTICLE
Prapaporn Chaniad, Arnon Chukaew, Prasit Na-Ek, Gorawit Yusakul, Litavadee Chuaboon, Arisara Phuwajaroanpong, Walaiporn Plirat, Atthaphon Konyanee, Abdi Wira Septama, Chuchard Punsawad
BACKGROUND: The potent antiplasmodial activity of 1-hydroxy-5,6,7-trimethoxyxanthone (HTX), isolated from Mammea siamensis T. Anders. flowers, has previously been demonstrated in vitro. However, its in vivo activity has not been reported. Therefore, this study aimed to investigate the antimalarial activity and acute toxicity of HTX in a mouse model and to evaluate the pharmacokinetic profile of HTX following a single intraperitoneal administration. METHODS: The in vivo antimalarial activity of HTX was evaluated using a 4-day suppressive test...
March 23, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38520287/impact-of-patient-specific-factors-on-clozapine-metabolism-in-individuals-with-treatment-resistant-schizophrenia-or-schizoaffective-disorder
#22
JOURNAL ARTICLE
Reza Rafizadeh, Anmol Sooch, Alessia Risi, Nicoline Bihelek, Kyler Kanegawa, Alasdair M Barr, Randall F White, Christian G Schütz, Chad A Bousman
BACKGROUND: There is high inter-individual variability in clozapine metabolism due to genetic and non-genetic differences. Patient-specific factors such as smoking, inflammation indicated by elevated C-reactive protein (CRP), and certain concurrent medications have a significant influence on clozapine metabolism. AIM: To assess which patient-specific factors best explain variability in clozapine metabolism estimated by clozapine concentration to dose (C/D) ratios...
March 23, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38519934/perioperative-outcomes-of-the-surgical-management-of-achalasia-in-two-tertiary-cameroonian-hospitals-a-cohort-study
#23
JOURNAL ARTICLE
Joël Igor Kamla, Guy Aristide Bang, Joel Noutakdie Tochie, George Motto Bwelle, Blondel Nana Oumarou, Bernadette Ngo Nonga
INTRODUCTION: Achalasia is a rare esophageal disease with potentially lethal complications. Knowledge of the outcomes of the different surgical treatment modalities for achalasia by Heller's cardiomyotomy (HCM) helps to choose the safest and most effective option. However, data on the management of achalsia using a Heller myotomy is limited in Africa. Thus, our aim was to determine the perioperative morbidity, mortality and short-term functional outcomes of HCM in Cameroon. METHODOLOGY: We conducted a cohort study throughout a 10-year chart review of patients who underwent HCM for achalasia and were followed up postoperatively for at least three months at two tertiary health centers in Cameroon...
March 22, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38518944/uncoordinated-51-like-kinase-1a-b-and-2-in-fish-megalobrama-amblycephala-molecular-cloning-functional-characterization-and-their-potential-roles-in-glucose-metabolism
#24
JOURNAL ARTICLE
Yanzou Dong, Xi Wang, Luyao Wei, Zishang Liu, Jingyu Zhou, Hanjing Zhao, Jianfeng Wang, Wenbin Liu, Xiangfei Li
Uncoordinated (Unc) 51-like kinase (ulk1) and ulk2 are closely involved in autophagy activation, but little is known about their roles in regulating glucose homeostasis. In this study, the genes of ulk1a, ulk1b and ulk2 were cloned and characterized in fish Megalobrama amblycephala. All the three genes shared the approximate N-terminal kinase domain and the C-terminal Atg1-like_tMIT domain structure, while the amino acid sequence identity of them are different between M. amblycephala and other vertebrates. Their transcripts were widely observed in various tissues (brain, muscle, gill, heart, spleen, eye, liver, intestine, abdominal adipose and kidney), but differed in tissue expression patterns...
March 20, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38517086/endoscopic-sphincterotomy-for-adults-with-biliary-sphincter-of-oddi-dysfunction
#25
REVIEW
Cho Naing, Han Ni, Htar Htar Aung, Chavdar S Pavlov
BACKGROUND: The sphincter of Oddi comprises a muscular complex encircling the distal part of the common bile duct and the pancreatic duct regulating the outflow from these ducts. Sphincter of Oddi dysfunction refers to the abnormal opening and closing of the muscular valve, which impairs the circulation of bile and pancreatic juices. OBJECTIVES: To evaluate the benefits and harms of any type of endoscopic sphincterotomy compared with a placebo drug, sham operation, or any pharmaceutical treatment, administered orally or endoscopically, alone or in combination, or a different type of endoscopic sphincterotomy in adults with biliary sphincter of Oddi dysfunction...
March 22, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38516814/review-article-new-developments-in-biomarkers-and-clinical-drug-development-in-alpha-1-antitrypsin-deficiency-related-liver-disease
#26
REVIEW
Rohit Loomba, Ginger Clark, Jeff Teckman, Veeral Ajmera, Cynthia Behling, Mark Brantly, David Brenner, Jeanine D'Armiento, Michael W Fried, Janani S Iyer, Mattias Mandorfer, Don C Rockey, Monica Tincopa, Raj Vuppalanchi, Zobair Younossi, Aleksander Krag, Alice M Turner, Pavel Strnad
BACKGROUND: Alpha-1 antitrypsin liver disease (AATLD) occurs in a subset of patients with alpha-1 antitrypsin deficiency. Risk factors for disease progression and specific pathophysiologic features are not well known and validated non-invasive assessments for disease severity are lacking. Currently, there are no approved treatments for AATLD. AIMS: To outline existing understanding of AATLD and to identify knowledge gaps critical to improving clinical trial design and development of new treatments...
March 22, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38515772/successful-coil-embolization-of-post-hepatectomy-arterioportal-fistula-that-reduced-ascites-and-improved-liver-function
#27
Ryuta Okuhira, Tetsuo Sonomura, Ryota Tanaka, Riki Inagaki, Shota Ueda, Kodai Fukuda, Nobuyuki Higashino, Atsufumi Kamisako, Hirotatsu Sato, Akira Ikoma, Hiroki Minamiguchi
A 71-year-old man had previously undergone S7 + S8 dorsal segmentectomy and S5 partial hepatectomy for hepatocellular carcinomas. Six months later, he experienced abdominal distention. Abdominal computed tomography (CT) showed massive ascites and a significant hepatic arterioportal shunt. The ascites was thought to be caused by portal hypertension due to a high-flow hepatic arterioportal fistula (HAPF). The fistula, located between the right hepatic artery A7 and the right portal vein, was embolized with microcoils under flow control using a balloon catheter...
June 2024: Radiology Case Reports
https://read.qxmd.com/read/38515503/acute-viral-hepatitis-e-infection-complicating-postliving-liver-donor-hepatectomy-recovery
#28
JOURNAL ARTICLE
Kaleem Ullah, Sidhant Ochani, Hafiz B Ahmad
This study presents a case of a living liver donor who developed a hepatitis E virus (HEV) infection postdonation, complicating his recovery. The donor was a 28-year-old male with no prior health issues who underwent a right lobe hepatectomy. Initially, his postoperative course was uneventful, but on the third postoperative day, he became lethargic and icteric. Laboratory tests showed elevated liver function markers, with peak levels on the 5th day. The HEV infection was confirmed through serological and polymerase chain reaction (PCR) testing...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38514990/unconjugated-hyperbilirubinemia-in-acetaminophen-related-acute-liver-failure
#29
JOURNAL ARTICLE
Marie Philippart, Jean-Baptiste Mesland, Vincent Haufroid, Christine Collienne, Philippe Hantson
BACKGROUND In the absence of liver transplantation, the natural history of acetaminophen-induced liver failure is characterized by a progressive increase of liver function tests, including bilirubin mainly as its conjugated form. The presence of high levels of unconjugated bilirubin is more unusual; its etiology is unclear and its prognostic factor has been poorly investigated. CASE REPORT A 52-year-old man with a history of chronic analgesics, alcohol, and illicit drug abuse developed acute liver failure in relationship with the ingestion of largely supra-therapeutic doses of acetaminophen over the days preceding admission...
March 22, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38514262/-study-based-on-the-acetaldehyde-dehydrogenase-2-gene-polymorphism-and-acetaminophen-induced-liver-injury
#30
JOURNAL ARTICLE
F Chen, Q H Li, Y J Wu, L Y Lyu, X M Xu, F Wang
Objective: To explore the association between aldehyde dehydrogenase 2 (ALDH2) gene polymorphisms and abnormal liver function-induced by acetaminophen (APAP) drugs. Methods: An ALDH2 gene knockout mouse model was constructed using CRISPR/Cas9 gene editing technology. The obtained heterozygous mice were mated with opposite sex of heterozygotes. Genomic DNA was extracted from the tail of the offspring mouse. The polymerase chain reaction (PCR) method was used to determine the ALDH2 genotype. APAP was further used to induce acute drug-induced liver injury models in wild-type and ALDH2 knockout mice...
February 20, 2024: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/38514261/-role-of-mitochondrial-autophagy-and-the-curative-effect-of-rehmannia-glutinosa-leaves-total-glycoside-capsules-on-nucleos-t-ide-drug-induced-renal-injury
#31
JOURNAL ARTICLE
K Zhong, M M Zhang, Z X Zhu, X Liao, B F Zhang, M L Cheng
Objective: To study the curative effect of rehmannia glutinosa leaves total glycoside capsules and the role of mitochondrial autophagy on nucleos(t)ide drug-induced renal injury. Methods: Adefovir dipivoxil (ADV) was used to construct a hepatitis B virus (HBV) transgenic mouse model for renal injury. Renal function was measured in each group at one and two weeks of modeling. Mitochondrial autophagy indicators were measured at two weeks of modeling in renal tissue. Transmission electron microscopy was used to detect mitochondrial autophagy phenomena in renal tissue...
February 20, 2024: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/38514259/-a-real-world-study-on-the-features-of-postpartum-hepatitis-flares-in-pregnant-women-with-chronic-hbv-infection
#32
JOURNAL ARTICLE
Z Zeng, M F Zhou, Y J Lin, X Y Bi, L Yang, W Deng, T T Jiang, L P Hu, M J Xu, L Zhang, W Yi, M H Li
Objective: To analyze the clinical features of postpartum hepatitis flares in pregnant women with hepatitis B virus (HBV) infection. Methods: A retrospective study was conducted. Patients who met the enrollment criteria were included. Liver function and HBV virology tests were collected from pregnant women with chronic HBV infection at delivery, 6, 24, 36, and 48 weeks after delivery through the hospital information and test system. Additionally, antiviral therapy types and drug withdrawal times were collected...
February 20, 2024: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/38512920/mortality-in-patients-with-normal-left-ventricular-function-requiring-emergency-va-ecmo-for-postcardiotomy-cardiogenic-shock-due-to-coronary-malperfusion
#33
JOURNAL ARTICLE
Jagdip Kang, Mateo Marin-Cuartas, Anna Flo Forner, Priya R Menon, André Ginther, Diyar Saaed, Suzanne de Waha, Massimiliano Meineri, Jörg Ender, Michael A Borger
OBJECTIVES: To analyze outcomes in patients with normal preoperative left ventricular ejection fraction (LVEF) undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy due to postcardiotomy cardiogenic shock (PCCS) related to coronary malperfusion. METHODS: Retrospective single-center analysis in patients with normal preoperative LVEF treated with VA-ECMO for coronary malperfusion-related PCCS between May 1998 and May 2018. The primary outcome was 30-day mortality, which was compared using the Kaplan-Meier method and the log-rank test...
2024: PloS One
https://read.qxmd.com/read/38511280/kikuchi-fujimoto-disease-during-early-pregnancy
#34
Go Ichikawa, Yasuyuki Negishi, Fumihisa Chishima, Shunji Suzuki
Kikuchi-Fujimoto disease (KFD) is rare during pregnancy. It is characterized by necrotizing lymphadenitis and often occurs in young Asian women. We report a case of KFD during pregnancy, which was difficult to diagnose. A 37-year-old pregnant female (gestational week [GW] 7+5 ) was admitted to our hospital because of hyperemesis gravidarum. On the eighth day of hospitalization (GW 8+6 ), she suddenly developed a fever (38.0°C) with skin rash and posterior pharynx redness. Blood tests showed pancytopenia and abnormal liver function...
March 21, 2024: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/38510786/the-efficacy-of-on-site-integration-screening-and-microelimination-programs-for-chronic-hepatitis-c-in-a-detection-center-a-comparison-of-the-treatment-outcomes-and-characteristics-of-incarcerated-patients-and-outpatients
#35
JOURNAL ARTICLE
Hsuan-Yuan Chang, Su-Hung Wang, Hsing-Tao Kuo, Ming-Jen Sheu, I-Che Feng, Chung-Han Ho, Jui-Yi Chen, Chi-Shu Sun, Chi-Hsing Chen, Cheng-Yi Lin, Chun-Chi Yang
We aimed to analyze the different patient characteristics and treatment outcomes (such as sustained viral response, SVR) between incarcerated patients with chronic hepatitis C (CHC) and those with CHC from the outpatient department through an on-site integrated screening and microelimination program in a detection center. In this retrospective study, which ran from May 2021 to April 2022, we included 32 consenting male prisoners aged at least 20 years who were willing to participate in the study. Members of the control group (who received DAAs in an outpatient setting) were selected from the treated CHC patient databank of individuals who received DAA regimens at Chi Mei Hospital between January 2021 and December 2022...
2024: International Journal of Hepatology
https://read.qxmd.com/read/38509578/gene-variants-and-clinical-characteristics-of-children-with-sitosterolemia
#36
JOURNAL ARTICLE
Rui Gu, Hui Wang, Chun-Lin Wang, Mei Lu, Miao Miao, Meng-Na Huang, Yi Chen, Yang-Li Dai, Ming-Qiang Zhu, Qiong Zhou, Chao-Chun Zou
OBJECTIVE: To enhance the detection, management and monitoring of Chinese children afflicted with sitosterolemia by examining the physical characteristics and genetic makeup of pediatric patients. METHODS: In this group, 26 children were diagnosed with sitosterolemia, 24 of whom underwent genetic analysis. Patient family medical history, physical symptoms, tests for liver function, lipid levels, standard blood tests, phytosterol levels, cardiac/carotid artery ultrasounds, fundus examinations, and treatment were collected...
March 20, 2024: Lipids in Health and Disease
https://read.qxmd.com/read/38509509/grade-adolopment-of-hyperthyroidism-treatment-guidelines-for-a-pakistani-context
#37
JOURNAL ARTICLE
Russell Seth Martins, Sarah Nadeem, Abeer Aziz, Sajjan Raja, Alina Pervez, Najmul Islam, Asma Ahmed, Aisha Sheikh, Saira Furqan, Nanik Ram, Azra Rizwan, Nashia Ali Rizvi, Mohsin Ali Mustafa, Salima Saleem Aamdani, Bushra Ayub, Muhammad Qamar Masood
INTRODUCTION: The prevalence of hyperthyroidism in Pakistan is 2.9%, which is two times higher than in the United States. Most high-quality hyperthyroidism clinical practice guidelines (CPGs) used internationally originate from high-income countries in the West. Local CPGs in Pakistan are not backed by transparent methodologies. We aimed to produce comprehensive, high-quality CPGs for the management of hyperthyroidism in Pakistan. METHODS: We employed the GRADE-ADOLOPMENT approach utilizing the 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis as the source CPG...
March 21, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38507367/thrombophilia-genetic-mutations-and-their-relation-to-disease-severity-among-patients-with-covid-19
#38
JOURNAL ARTICLE
Hend Moness, Suzan Omar Mousa, Sarah Omar Mousa, Nashwa Mohamed Adel, Reham Ali Ibrahim, Ebtesam Esmail Hassan, Nadia Ismail Abdelhameed, Dalia Abdelrahman Meshref, Noha M Abdullah
OBJECTIVES: Patients with COVID-19 infection appear to develop virus-induced hypercoagulability resulting in numerous thrombotic events. The aim of the present study was to determine the relationship between the thrombophilia genes mutations (prothrombin G20210A, factor V Leiden, and methyltetrahydrofolate reductase (MTHFR)) and the severity of COVID-19 patients. DESIGN: Prospective cross-sectional study. METHOD: One hundred and forty patients (80 adults and 60 children) were included in the current study...
2024: PloS One
https://read.qxmd.com/read/38507233/anoikis-related-lncrna-signature-predicts-prognosis-and-is-associated-with-immune-infiltration-in-hepatocellular-carcinoma
#39
JOURNAL ARTICLE
Jiahong Zhu, Wenjing Zhao, Junkai Yang, Cheng Liu, Yilang Wang, Hui Zhao
Anoikis is a programmed cell death process triggered when cells are dislodged from the extracellular matrix. Numerous long noncoding RNAs (lncRNAs) have been identified as significant factors associated with anoikis resistance in various tumor types, including glioma, breast cancer, and bladder cancer. However, the relationship between lncRNAs and the prognosis of hepatocellular carcinoma (HCC) has received limited research attention. Further research is needed to investigate this potential link and understand the role of lncRNAs in the progression of HCC...
March 11, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38506935/combination-of-a-glissonean-approach-and-indocyanine-green-fluorescence-imaging-to-perform-a-laparoscopic-right-anterior-sectionectomy
#40
JOURNAL ARTICLE
Marie Livin, Amine Sebai, Stylianos Tzedakis, Hassene Hajji, Karim Boudjema, Heithem Jeddou
BACKGROUND: Laparoscopic right anterior sectionectomy (LRAS) remains a technically demanding procedure as it requires two transection planes where the middle and right hepatic veins run; however, the main difficulty is locating these two planes1-3 . The aim of this video was to show the technique of an LRAS performed with a transparenchymal glissonean pedicle approach and guided by indocyanine green (ICG) staining. METHODS: This was the case of an 80-year-old man with a history of hemochromatosis and normal liver function...
March 20, 2024: Annals of Surgical Oncology
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