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JOURNAL ARTICLE
A J Hirsch Allen, Tetyana Kendzerska, Parveen Bhatti, Rachel Jen, Renelle Myers, Mohammadreza Hajipour, Stephan F van Eeden, Najib Ayas
STUDY OBJECTIVES: To determine if obstructive sleep apnea (OSA) severity and/or biomarkers of inflammation/angiogenesis are associated with incident cancer in this clinical cohort. METHODS: Consenting adult patients at the University of British Columbia Hospital between 2003-2014 completed a questionnaire about their medical history and sleep habits prior to undergoing a polysomnogram (PSG). Blood samples were collected the morning after PSG and processed for biomarkers of inflammation and angiogenesis...
April 22, 2024: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
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JOURNAL ARTICLE
Yahong Xue, Huifen Zhou, Yusha Zeng, Chen Wang, Yun Yang, Xiaopeng Wang, Zongqi He, Yibo Yao, Xiaofeng Wang, Zhimin Fan
BACKGROUND: Some Chinese scholars have initially explored the efficacy of electroacupuncture at Baliao acupoint in patients with functional anorectal pain (FAP). However, their studies are performed in a single center, or the sample size is small. Therefore, we aim to further explore the efficacy of electroacupuncture at Baliao acupoint on the treatment of FAP. METHODS: In this multicenter randomized controlled trial, 136 eligible FAP patients will be randomly allocated into an electroacupuncture group or sham electroacupuncture group at a 1:1 ratio...
April 22, 2024: International Journal of Colorectal Disease
#3
JOURNAL ARTICLE
Magali Devriese, François A Lemonnier, Julien Lion, Caroline Sayegh, Emma Fleury, Catherine Shofstall, Lisa Giraldo, Quentin Fiachetti, Cédric Usureau, Hiroko Miyadera, Olivier Toutirais, Nuala Mooney, Dave Lowe, Jean-Luc Taupin
In transplantation, anti-HLA Abs, especially targeting the DQ locus, are well-known to lead to rejection. These Abs identified by Luminex single Ag assays recognize polymorphic amino acids on HLA, named eplets. The HLA Eplet Registry included 83 DQ eplets, mainly deduced from amino acid sequence alignments, among which 66 have not been experimentally verified. Because eplet mismatch load may improve organ allocation and transplant outcomes, it is imperative to confirm the genuine reactivity of eplets to validate this approach...
April 22, 2024: Journal of Immunology
#4
JOURNAL ARTICLE
Size Li, Xu Zhu, Guoying Cao, Jufang Shen, Xu Zhu, Jicheng Yu, Xiaojie Wu, Jufang Wu, Haijing Yang, Nanyang Li, Yingying Hu, Jingjing Wang, Haihui Huang, Jing Zhang
EVER206 (also known as SPR206) is a novel polymyxin analog that has shown in vitro potency and in vivo efficacy against multidrug-resistant (MDR) Gram-negative pathogens. This randomized, double-blinded, placebo-controlled, Phase I study evaluated the safety, tolerability, and pharmacokinetics of EVER206 in healthy Chinese subjects. After single administration of 50-300 mg EVER206, the Cmax ranged from 3.94 to 25.82 mg/L, and the AUC0-inf ranged from 12.42 to 101.67 h·mg/L. The plasma exposure displayed a linear relationship with the dose administered...
April 22, 2024: Antimicrobial Agents and Chemotherapy
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JOURNAL ARTICLE
Stefan D Holubar, Douglas Nachand, Olga Lavryk, Mikhael Belkovsky, Rita Brienza, Nour Mohammed, Justin Ream, Tracy Hull, Scott R Steele, Miguel Regueiro, Benjamin L Cohen, Taha Qazi, Florian Rieder
BACKGROUND: Herein, we present a proof-of-concept study of 3-dimensional (3D) pouchography using virtual and printed 3D models of ileal pouch-anal anastomosis (IPAA) in patients with normal pouches and in cases of mechanical pouch complications. MATERIALS & METHODS: We performed a retrospective, descriptive case series of a convenience sample of 10 pouch patients with or without pouch dysfunction who had CT scans appropriate for segmentation were identified from our pouch registry...
April 22, 2024: Journal of Crohn's & Colitis
#6
JOURNAL ARTICLE
Johan Wassélius, Emma Hall, Birgitta Ramgren, Tommy Andersson, Teresa Ullberg
INTRODUCTION: Several studies have addressed technical aspects of endovascular thrombectomy (EVT), but it is not well known how procedural factors contribute to technical success in routine healthcare. The aim was to explore factors associated with technically successful EVT on nationwide scale. METHODS: We did an observational register-based study assessing factors associated with technical success off anterior circulation EVT in Sweden. The main outcome was successful recanalization defined as modified treatment in cerebral ischemia score 2b-3...
April 22, 2024: Interventional Neuroradiology
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JOURNAL ARTICLE
M Usman Ahmad, David Lee, Lakshika Tennakoon, Tiffany Erin Chao, David Spain, Kristan Staudenmayer
BACKGROUND: Splenic angioembolization (SAE) has increased in utilization for blunt splenic injuries. We hypothesized lower SAE usage would not correlate with higher rates of additional intervention or mortality when choosing initial non-operative management (NOM) or surgery. STUDY DESIGN: Trauma registries from two level I trauma centers from 2010 to 2020 were used to identify patients aged >18 years with grade III-V blunt splenic injuries. Results were compared with the National Trauma Data Bank (NTDB) for 2018 for level I and II centers...
2024: Trauma Surgery & Acute Care Open
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JOURNAL ARTICLE
Guri Hagberg, Haakon Ihle-Hansen, Tamar Abzhandadze, Malin Reinholdsson, Adam Viktorisson, Hege Ihle-Hansen, Katharina Stibrant Sunnerhagen
BACKGROUND: The shift towards milder strokes and studies suggesting that stroke symptoms vary by age and sex may challenge the Face-Arm-Speech Time (FAST) coverage. We aimed to study the proportion of stroke cases admitted with FAST symptoms, sex and age differences in FAST presentation and explore any additional advantage of including new item(s) from the National Institute of Health Stroke Scale (NIHSS) to the FAST algorithm. METHODS: This registry-based study included patients admitted with acute stroke to Sahlgrenska University Hospital (November 2014 to June 2019) with NIHSS items at admission...
2024: BMJ neurology open
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JOURNAL ARTICLE
Nanjin Chen, Shuman Ji, Junfei Liu, Liping Wang, Fenglin Chen, Yanwu Zhu, Jiao Li, Minjuan Chen, Lingyang Chen, Mingcang Wang, Ruyi He, Xiaopeng Mei, Zhanqin Zhang, Shengwei Jin, Jingming Zheng, Yongpo Jiang
PURPOSE: This study was designed to investigate the prophylactic effect of oral olanzapine in postoperative nausea and vomiting after gynecologic laparoscopic surgery. METHODS: ASA I-II, aged 18-75 years, planned to undergo gynecologic laparoscopic surgery with general anesthesia in adult female patients. Using the randomized numbers table, the patients were placed in two groups. Oral olanzapine 5 mg or placebo was given 1 h before anesthesia...
2024: Therapeutic Advances in Drug Safety
#10
REVIEW
Shannon Giliberto, Rhea Shishodia, Meredith Nastruz, Chamandeep Brar, Sadeepa Bulathsinhala, Jonathan Terry, Sudhakar Pemminati, Sudhakar K Shenoy
Mental health disorders are among the top leading causes of disease burden worldwide and many patients have high levels of treatment resistance. Even though medications offer improvement to some patients, antidepressants are only effective in about half of those treated, and schizophrenia is treatment-refractory in about one-third of patients. One way to combat this disparity is to improve medication development and discovery for psychiatric disorders through evidence-based research. Recently, most psychiatric medications approved by the United States Food and Drug Administration (FDA) are for increased tolerability or extended release...
March 2024: Curēus
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JOURNAL ARTICLE
Moshumi Godbole, Samantha Olafson, Ryan B Cohen, Candace L Ward, Stephanie Sailes, Mia Sharlin, Afshin Parsikia, Benjamin J Moran, Pak Shan P Leung
Background Resuscitative thoracotomy (RT) is performed in severe trauma cases as a final lifesaving effort. Prominent, yet differing, practice management guidelines exist from Eastern Association for the Surgery of Trauma (EAST) and Western Trauma Association (WTA). This study evaluates all RTs performed from 2012 to 2019 at an urban Level 1 trauma center for management guideline indication and subsequent outcomes. Methods Our trauma registry was queried to identify RT cases from 2012 to 2019. Data was collected on patient demographics, prehospital presentation, cardiopulmonary resuscitation (CPR) requirements, and resuscitation provided...
March 2024: Curēus
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JOURNAL ARTICLE
Reena Dhanda Patil, Maria V Suurna, Armin Steffen, Ryan Soose, James Coxe, Teresa Chan, Stacey L Ishman
OBJECTIVE: In patients undergoing hypoglossal nerve stimulation (HGNS), we examined the Insomnia Severity Index (ISI) to understand how baseline sleep onset insomnia (SOI), sleep maintenance insomnia (SMI), and early morning awakening (EMA) affected postsurgical outcomes. STUDY DESIGN: Observational. SETTING: Multicenter registry. METHODS: We included patients from the Adherence and Outcomes of Upper Airway Stimulation for Obstructive Sleep Apnea International Registry (ADHERE) with a baseline ISI from 2020 to 2023...
2024: OTO Open
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JOURNAL ARTICLE
Joo Hee Jeong, Kwang-Sig Lee, Seong-Mi Park, So Ree Kim, Mi-Na Kim, Shung Chull Chae, Seung-Ho Hur, In Whan Seong, Seok Kyu Oh, Tae Hoon Ahn, Myung Ho Jeong
Several regression-based models for predicting outcomes after acute myocardial infarction (AMI) have been developed. However, prediction models that encompass diverse patient-related factors over time are limited. This study aimed to develop a machine learning-based model to predict longitudinal outcomes after AMI. This study was based on a nationwide prospective registry of AMI in Korea ( n = 13,104). Seventy-seven predictor candidates from prehospitalization to 1 year of follow-up were included, and six machine learning approaches were analyzed...
2024: Frontiers in Cardiovascular Medicine
#14
JOURNAL ARTICLE
Tomás Barry, Alice Kasemiire, Martin Quinn, Conor Deasy, Gerard Bury, Siobhan Masterson, Ricardo Segurado, Andrew W Murphy
AIM: To explore potential predictors of national out-of-hospital cardiac arrest (OHCA) survival, including health system developments and the COVID pandemic in Ireland. METHODS: National level OHCA registry data from 2012 through to 2020, relating to unwitnessed, and bystander witnessed OHCA were interrogated. Logistic regression models were built by including predictors through stepwise variable selection and enhancing the models by adding pairwise interactions that improved fit...
June 2024: Resuscitation plus
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JOURNAL ARTICLE
Alfredo Echarri Sucunza, Patricia Fernández Del Valle, Jose Antonio Iglesias Vázquez, Youcef Azeli, Jose María Navalpotro Pascual, Juan Valenciano Rodriguez, Cristian Fernández Barreras, Sonia Royo Embid, Carmen Gutiérrez-García, María Isabel Ceniceros Rozalén, Cesar Manuel Guerra García, Carmen Del Pozo Pérez, María José Luque-Hernández, Silvia Sola Muñoz, Ana Belén Forner Canos, María Isabel Herrera Maíllo, Marcos Juanes García, Natividad Ramos García, Belén Muñoz Isabel, Junior Jose García Mendoza, José Antonio Cortés Ramas, Faustino Redondo Revilla, Inmaculada Mateo-Rodríguez, Félix Rivera Sanz, Emily Knox, Antonio Daponte Codina, José Ignacio Ruiz Azpiazu, Fernando Rosell Ortiz
INTRODUCTION: Recent data are not available on ongoing CPR for emergency services with an onboard physician. The aim of the present study was to identify factors associated with the decision to transport patients to hospital with ongoing CPR and examine their survival to hospital discharge with good neurological status. METHODS: An observational study based on a registry of out-of-hospital cardiac arrests attended to by emergency services with an onboard physician...
June 2024: Resuscitation plus
#16
JOURNAL ARTICLE
Arumugham Kanakaraj, Rajan Ravichandran
No abstract text is available yet for this article.
2024: Indian Journal of Nephrology
#17
JOURNAL ARTICLE
Shalini Santhakumaran, Louis Fisher, Bang Zheng, Viyaasan Mahalingasivam, Lucy Plumb, Edward Pk Parker, Retha Steenkamp, Caroline Morton, Amir Mehrkar, Sebastian Bacon, Sue Lyon, Rob Konstant-Hambling, Ben Goldacre, Brian MacKenna, Laurie A Tomlinson, Dorothea Nitsch
OBJECTIVE: To validate primary and secondary care codes in electronic health records to identify people receiving chronic kidney replacement therapy based on gold standard registry data. DESIGN: Validation study using data from OpenSAFELY and the UK Renal Registry, with the approval of NHS England. SETTING: Primary and secondary care electronic health records from people registered at 45% of general practices in England on 1 January 2020, linked to data from the UK Renal Registry (UKRR) within the OpenSAFELY-TPP platform, part of the NHS England OpenSAFELY covid-19 service...
2024: BMJ Med
#18
REVIEW
Chi-Cheng Li, Xavier Cheng-Hong Tsai, Wei-Han Huang, Tso-Fu Wang
Hematopoietic stem cell transplantation (HSCT) can cure malignant and nonmalignant hematological disorders. From 1983 to 2022, Taiwan performed more than 10,000 HSCT transplants. The Taiwan Blood and Marrow Transplantation Registry collects clinical information to gather everyone's experience and promote the advances of HSCT in Taiwan to gather everyone's experience and promote advances of HSCT in Taiwan. Compared with matched sibling donors, transplants from matched unrelated donors exhibited a trend of superior survival...
2024: Tzu chi medical journal
#19
JOURNAL ARTICLE
Kuo-Liang Yang, Py-Yu Lin
OBJECTIVES: It is thought that Taiwanese indigenous people were the "first people" to populate Taiwan (Formosa) having been there for over 5000 years, preceding the Dutch colonization (from 1624 to 1662) and Spanish colonization (from 1626 to 1642). Taiwan's indigenes, represented by Austronesian language speakers, currently constitute approximately 2% of the total population in Taiwan. It is unknown whether they evolved from Taiwan's Paleolithic or Neolithic cultures, arrived during or after the Neolithic period from China or Southeast Asia or both...
2024: Tzu chi medical journal
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JOURNAL ARTICLE
Onanong Phokaewvarangkul, Nithinan Kantachadvanich, Vijittra Buranasrikul, Kanyawat Sanyawut, Saisamorn Phumphid, Chanawat Anan, Roongroj Bhidayasiri
INTRODUCTION: Apomorphine, a potent dopamine agonist, is a therapeutic option for patients with Parkinson's disease and motor fluctuations. However, the adoption of and adherence to this therapy have been limited by the need for complex delivery devices and specialized care as well as resource consumption, posing challenges for new physicians. Thailand is a unique example of a developing nation that has successfully implemented and continued the use of this therapy by employing cooperative technology that has dramatically enhanced apomorphine delivery services...
2024: Frontiers in Neurology
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