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https://www.readbyqxmd.com/read/27910705/left-right-differences-in-ovarian-volume-and-antral-follicle-count-in-1423-women-of-reproductive-age
#1
Anne-Sofie Korsholm, Helene Westring Hvidman, Janne Gasseholm Bentzen, Anders Nyboe Andersen, Kathrine Birch Petersen
The aim of this cross-sectional study was to investigate side differences in antral follicle count (AFC) and ovarian volume in left versus right ovaries in relation to chronological and "biological" age, the latter estimated by anti-Müllerian hormone (AMH) levels. The cohort comprised 1423 women: 1014 fertile and 409 infertile. All were examined by transvaginal sonography and serum AMH. Overall the right ovary contained 8.1% more antral follicles (p = 0.002) and had 10.7% larger volume compared with the left (p < 0...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27892637/distribution-of-follicles-in-canine-ovarian-tissues-and-xenotransplantation-of-cryopreserved-ovarian-tissues-with-even-distribution-of-follicles
#2
I Wakasa, M Hayashi, Y Abe, H Suzuki
Ovarian follicles are not homogeneously distributed within the ovarian cortex in several species of mammals. Yet to maximize the reproducibility of experimental results of ovarian transplantation, it is essential to assess the degree of density and distribution of follicles in ovarian tissues before their transplantation. In this study, the ovarian cortex from 13 immature bitches (ten purebred and three mongrels) was sectioned into 1.0- to 1.5-mm(3) cubes, those were fixed, sectioned and stained with haematoxylin and eosin...
November 28, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27890351/unilaminar-follicular-cells-transiently-express-galectin-3-during-ovarian-folliculogenesis-in-pigs
#3
Seung-Dam Heo, Changnam Park, Jeongtae Kim, Meejung Ahn, Taekyun Shin
The localization of galectin-3, a β-galactoside-binding animal lectin, was immunohistochemically studied in the ovaries of pigs to determine its expression in ovarian folliculogenesis. Various stages of ovarian follicles were identified in the ovaries of adult pigs. Galectin-3 was immunostained in the squamous follicular cells surrounding oocytes in primordial follicles and in the unilaminar granulosa cells of primary follicles, but not in oocytes of multilaminar follicles (including primary, secondary, and tertiary Graafian follicles)...
November 17, 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27889913/long-term-melatonin-treatment-delays-ovarian-aging
#4
Hiroshi Tamura, Mai Kawamoto, Shun Sato, Isao Tamura, Ryo Maekawa, Toshiaki Taketani, Hiromi Aasada, Eiichi Takaki, Akira Nakai, Russel J Reiter, Norihiro Sugino
Ovarian aging is characterized by gradual declines in oocyte quantity and quality. Melatonin is considered an anti-aging agent due to its cytoprotective actions as an antioxidant. The present study examined whether long-term melatonin treatment would delay ovarian aging in mice. Female ICR mice (10 weeks old) were given melatonin-containing water (100 μg/ml; melatonin) or water only until 43 weeks of age. Their oocytes were recovered from the oviduct, and in vitro fertilization was performed. The ovaries were used for a histological analysis of the number of follicles...
November 27, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27866379/effects-of-oral-exposure-to-the-phthalate-substitute-acetyl-tributyl-citrate-on-female-reproduction-in-mice
#5
Lindsay M Rasmussen, Nivedita Sen, Xiaosong Liu, Zelieann R Craig
Acetyl tributyl citrate (ATBC), is a phthalate substitute used in food and medical plastics, cosmetics and toys. Although systemically safe up to 1000 mg kg(-1)  day(-1) , its ability to cause reproductive toxicity in females at levels below 50 mg kg(-1)  day(-1) has not been examined. This study evaluated the effects of lower ATBC exposures on female reproduction using mice. Adult CD-1 females (n = 7-8 per treatment) were dosed orally with tocopherol-stripped corn oil (vehicle), 5 or 10 mg kg(-1)  day(-1) ATBC daily for 15 days, and then bred with a proven breeder male...
November 20, 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27856623/kisspeptin-level-in-the-aging-ovary-is-regulated-by-the-sympathetic-nervous-system
#6
Daniela Fernandois, Gonzalo Cruz, Eun Kyung Na, Hernán E Lara, Alfonso H Paredes
Previous work has demonstrated that the increase in the activity of sympathetic nerves, which occurs during the subfertility period in female rats, causes an increase in follicular cyst development and impairs follicular development. In addition, the increase in ovarian sympathetic activity of aged rats correlates with an increased expression of kisspeptin (KISS1) in the ovary. This increase in KISS1 could participate in the decrease in follicular development that occurs during the subfertility period. We aimed to determine whether the blockade of ovarian sympathetic tone prevents the increase in KISS1 expression during reproductive aging and improves follicular development...
January 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/27852727/ovarian-tissue-culture-in-presence-of-vegf-and-fetuin-stimulates-follicle-growth-and-steroidogenesis
#7
Ebrahim Asadi, Atefeh Najafi, Ashraf Moeini, Reihaneh Pirjani, Gholamreza Hassanzadeh, Saideh Mikaeili, Ensieh Salehi, Emmanuel Adutwum, Mansoureh Soleimani, Fariba Khosravi, Mahmood Barati, Farid Abohassani
Ovarian tissue cryopreservation together with follicle culture provides a promising technique for fertility preservation in cancer patients. The study aimed to evaluate follicle parameters in a culture medium supplemented with VEGFA165 and/or fetuin. Vitrified-warmed ovarian cortical pieces were divided randomly into four culture groups consisting of basic culture medium (control), and the basic culture medium supplemented with VEGFA165, fetuin or both. After six days of culture, we evaluated the following: percentage of resting, primary and secondary growing follicles; survival rate; steroid hormones production; levels of reactive oxygen species, lipid peroxidation and total antioxidant capacity; and developmental and antioxidant gene expression...
November 16, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27848973/progesterone-receptor-membrane-component-1-mediates-progesterone-induced-suppression-of-oocyte-meiotic-prophase-i-and-primordial-folliculogenesis
#8
Meng Guo, Cheng Zhang, Yan Wang, Lizhao Feng, Zhengpin Wang, Wanbo Niu, Xiaoyan Du, Wang Tang, Yuna Li, Chao Wang, Zhenwen Chen
Well-timed progression of primordial folliculogenesis is essential for mammalian female fertility. Progesterone (P4) inhibits primordial follicle formation under physiological conditions; however, P4 receptor that mediates this effect and its underlying mechanisms are unclear. In this study, we used an in vitro organ culture system to show that progesterone receptor membrane component 1 (PGRMC1) mediated P4-induced inhibition of oocyte meiotic prophase I and primordial follicle formation. We found that membrane-impermeable BSA-conjugated P4 inhibited primordial follicle formation similar to that by P4...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27833962/changes-in-rat-ovary-with-experimentally-induced-diabetes-and-the-effects-of-lycopene-on-those-changes
#9
Mustafa Yildiz, Mustafa Sandikci
Free radicals increase in the presence of diabetes. Lycopene is a powerful antioxidant. The goal of the present study was to determine the effect of diabetes on rat ovaries and the protective role of lycopene in that context. Experimental diabetes was induced with 50 mg÷kg streptozotocin. Rats were randomly separated into four groups, as follows: control + corn oil, control + lycopene, diabetes + corn oil and diabetes + lycopene. The histological and histometric evaluations were performed using Crossman's triple staining method...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27831564/skin-derived-stem-cells-as-a-source-of-primordial-germ-cell-and-oocyte-like-cells
#10
REVIEW
Wei Ge, Shun-Feng Cheng, Paul W Dyce, Massimo De Felici, Wei Shen
The skin is a unique organ that contains a variety of stem cells for the maintenance of skin homeostasis and the repair of skin tissues following injury and disease. Skin-derived stem cells (SDSCs) constitute a heterogeneous population of stem cells generated in vitro from dermis, which can be cultured as spherical aggregates of cells in suspension culture. Under certain in vitro or in vivo conditions, SDSCs show multipotency and can generate a variety of neural, mesodermal, and endodermal cell types such as neurons, glia, fibroblasts, adipocytes, muscle cells, chondroblasts, osteoblats, and islet β-cell-like cells...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27815062/short-term-exposure-of-human-ovarian-follicles-to-cyclophosphamide-metabolites-seems-to-promote-follicular-activation-in-vitro
#11
Yechezkel Lande, Benjamin Fisch, Abraham Tsur, Jacob Farhi, Roni Prag-Rosenberg, Avi Ben-Haroush, Gania Kessler-Icekson, Muayad A Zahalka, Susan M Ludeman, Ronit Abir
How chemotherapy affects dormant ovarian primordial follicles is unclear. The 'burnout' theory, studied only in mice, suggests cyclophosphamide enhances primordial follicle activation. Using 4-hydroperoxycyclophosphamide (4hc) and phosphoramide mustard (PM), this study assessed how the active cyclophosphamide metabolites 4-hydroxycyclophosphamide (4-OHC) and PM, affect human primordial follicles. Frozen-thawed human ovarian samples were sliced and cultured with basic culture medium (cultured controls) or with 4hc/PM (3 µmol/l/10 µmol/l) (treated samples) for 24-48 h...
October 17, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27774658/the-localization-of-kisspeptin-and-kisspeptin-receptor-in-the-canine-ovary-during-different-stages-of-the-reproductive-cycle
#12
M E Cielesh, B M McGrath, C J Scott, S T Norman, C P Stephen
Kisspeptin is a neuropeptide involved in the hypothalamic regulation of reproduction in many species. Recent studies have revealed kisspeptin within the ovaries of rats, Siberian hamsters and humans, indicating a local role in reproduction. However, the role of kisspeptin in the ovary is poorly understood in the bitch. This study investigated the presence and location of kisspeptin protein (KISS1) and kisspeptin receptors (KISS1R) in the canine ovary during different stages of the reproductive cycle (pre-pubertal, anoestrus and cycling) by means of immunohistochemical staining...
October 23, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27771355/ovarian-aging-and-the-activation-of-the-primordial-follicle-reserve-in-the-long-lived-ames-dwarf-and-the-short-lived-bgh-transgenic-mice
#13
Tatiana D Saccon, Fabiana Moreira, Luis A Cruz, Rafael G Mondadori, Yimin Fang, Carlos C Barros, L Spinel, A Bartke, Michal M Masternak, A Schneider
The aim of this study was to evaluate the effect of growth hormone (GH) in the maintenance of the ovarian primordial follicle reserve. Ovaries from 16 mo old GH-deficient Ames Dwarf (df/df) and Normal (N/df) mice were used. A subgroup of df/df and N mice received GH or saline injections for six weeks starting at 14 mo of age. In addition, ovaries from 12 mo old mice overexpressing bovine GH (bGH) and controls were used. df/df mice had higher number of primordial and total follicles than N/df mice (p < 0...
October 19, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27758003/evaluation-of-follicular-growth-and-tissue-viability-in-vitrified-warmed-domestic-dog-ovaries-after-in-vitro-culture
#14
C L Ackermann, C S Asa, R Krisher, K Bauman, S Casey, M D Lopes
Cryopreservation of gametes is an important tool to preserve fertility, but for most species, including domestic dogs, data regarding ovarian tissue cryopreservation are limited. We aimed to evaluate the follicular and tissue viability and follicular growth after in vitro culture of domestic dog ovarian cortical slices cryopreserved by vitrification. Ovarian cortex was obtained from ten pairs of ovaries from domestic dogs using two methods (A and B), one for each ovary from the same bitch. At least four slices for each method were obtained from each ovary, one was processed for histology and the other three were vitrified...
October 18, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27746501/radiologic-and-histological-observations-in-experimental-t1-t12-dorsal-arthrodesis-a-qualitative-description-of-t1-t12-segment-and-other-body-parts-involved-between-prepubertal-age-and-skeletal-maturityxs
#15
Federico Canavese, Alain Dimeglio, Davide Barbetta, Marco Galeotti, Bartolomeo Canavese, Fabio Cavalli
BACKGROUND: This experimental study provides a qualitative description and the morpho-structural features of the fusions taking place in the thoracic spine between prepubertal age and skeletal maturity. There is a lack of informations regarding the influence of partial or total dorso-thoracic vertebral arthrodesis on the development of the thoracic cage as well as its potential effects on different intra and extra-thoracic organs. This study admits the hypothesis that vertebral arthrodesis may have influence on other body areas and so, it intends to verify the possible secondary involvement of other body parts, such as intervertebral discs, cervical and thoracic spinal ganglia, sternocostal cartilage, ovaries and lungs...
September 2016: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/27734842/growth-arrest-specific-2-gas2-is-a-critical-mediator-of-germ-cell-cyst-breakdown-and-folliculogenesis-in-mice
#16
J Philippe York, Yi Athena Ren, Jie Zeng, Bin Zhang, Fang Wang, Rui Chen, Jianqiao Liu, Xuefeng Xia, Pumin Zhang
In the mouse ovary, the primordial follicle pool is established through a diverse array of signaling pathways and tissue remodeling events. Growth arrest specific gene two (GAS2) is a highly conserved cytoskeleton-associated protein whose in vivo function remains unclear. In Drosophila, loss of the GAS2 homolog, Pigs, results in infertility. We demonstrate herein that, in the mouse ovary, GAS2 is expressed in the stromal cells surrounding the oocyte cysts on 16.5 dpc, and in stromal cells surrounding growing follicles during juvenile and adult life...
October 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27722934/ovarian-tissue-cryopreservation-and-transplantation-scientific-implications
#17
Sherman Silber
After fresh or frozen ovary transplantation, FSH levels return to normal, and menstrual cycles resume by 150 days, coincident with anti-Müllerian hormone rising to higher than normal levels. AMH then returns to well below normal levels by 240 days, remaining as such for many years with nonetheless normal ovulation and fertility. To date, 20 babies have been born in our program from 11 fresh and 13 cryopreserved ovary transplant recipients with a live baby rate of over 70 % (11 babies from fresh and 9 from frozen)...
October 8, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27710922/hyaluronic-acid-based-hydrogel-scaffold-without-angiogenic-growth-factors-enhances-ovarian-tissue-function-after-autotransplantation-in-rats
#18
Somayeh Tavana, Mahnaz Azarnia, Mojtaba Rezazadeh Valojerdi, Abdolhossein Shahverdi
One of the problems encountered during ovarian transplantation is that the number of primordial follicles in the grafts is considerably reduced 2 d after transplantation due to post-transplantation ischemia. This study investigates if the use of hyaluronic acid-based hydrogel (HABH) with and without vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) could prevent or minimize ischemia-induced follicle loss during ovarian autotransplantation and thereby restore ovarian tissue function in the rat model...
October 6, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27702318/in-vitro-activation-a-dip-into-the-primordial-follicle-pool
#19
Ophelia Yin, Kamaria Cayton, James H Segars
CONTEXT: A current limitation of assisted reproduction is the number of available female gametes. This Commentary discusses in vitro activation (IVA), a technique that activates dormant ovarian follicles so that these follicles can become mature oocytes for fertilization. There is considerable evidence that mechanical signaling plays an important role in oocyte maturation and survival; manipulation of the mechanical environment is a key component of the IVA process. IVA acts on existing follicles and does not promote neo-oogenesis, which likely contributes little to the primordial follicle pool in the adult...
October 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27698208/regulation-of-steroidogenesis-in-fetal-bovine-ovaries-differential-effects-of-lh-and-fsh
#20
Jeremy J Allen, Susan L Herrick, Joanne E Fortune
In cattle, primordial follicles form before birth. Fetal ovarian capacity to produce progesterone and estradiol is high before follicle formation begins and decreases around the time follicles first appear (around 90 days of gestation). However, mechanisms that regulate steroid production during this time remain unclear. We hypothesized that LH stimulates progesterone and androgen production and that FSH stimulates aromatization of androgens to estradiol. To test this, we cultured pieces from fetal bovine ovaries for 10 days without or with exogenous hormones and then measured the accumulation of steroids in the culture medium by RIA...
October 3, 2016: Journal of Molecular Endocrinology
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