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https://www.readbyqxmd.com/read/28615648/embryonic-exposure-to-the-widely-used-herbicide-atrazine-disrupts-meiosis-and-normal-follicle-formation-in-female-mice
#1
Aurore Gely-Pernot, Souhila Saci, Pierre-Yves Kernanec, Chunxiang Hao, Frank Giton, Christine Kervarrec, Sergei Tevosian, Severine Mazaud-Guittot, Fatima Smagulova
The widely-used herbicide atrazine (ATZ) is detected in ground and surface water in many countries. Several studies in animals have demonstrated that ATZ has endocrine-disrupting effects on male and female reproduction in many vertebrate species. In this study, we investigated the effects of ATZ exposure on meiosis, a key step in gametogenesis in mammals. The treatment was initiated before oocyte entry into meiosis, which occurs during the embryonic period in females. We found that embryonic exposure to ATZ increases the level of 8-oxo-guanine in the nucleus of meiotic cells, reflecting oxidative stress and affecting meiotic double-strand break repair, chromosome synapsis and crossover numbers...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28604658/in-vitro-differentiation-of-human-embryonic-stem-cells-into-ovarian-follicle-like-cells
#2
Dajung Jung, Jie Xiong, Min Ye, Xunsi Qin, Lin Li, Shunfeng Cheng, Mengyuan Luo, Jia Peng, Ji Dong, Fuchou Tang, Wei Shen, Martin M Matzuk, Kehkooi Kee
Understanding the unique mechanisms of human oogenesis necessitates the development of an in vitro system of stem cell differentiation into oocytes. Specialized cell types and organoids have been derived from human pluripotent stem cells in vitro, but generating a human ovarian follicle remains a challenge. Here we report that human embryonic stem cells can be induced to differentiate into ovarian follicle-like cells (FLCs) in vitro. First, we find that two RNA-binding proteins specifically expressed in germ cells, DAZL and BOULE, regulate the exit from pluripotency and entry into meiosis...
June 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28601152/identification-and-expression-of-x-linked-inhibitor-of-apoptosis-protein-during-follicular-development-in-goat-ovary
#3
Peng Han, Haiyun Xin, Jiayin Peng, Jinxing Hou, Lei Zhang, Yuxuan Song, Guang Li, Binyun Cao, Xiaopeng An
X-linked inhibitor of apoptosis protein (XIAP), an endogenous of inhibitor of caspases, plays crucial roles in regulating ovarian granulosa cell apoptosis during follicular atresia. The aim of the present study was to determine the presence and localization of XIAP in the goat ovary and its expression level during follicular development. The full length cDNA of XIAP from goat ovary cells was cloned using reverse transcription PCR. A total of 497 amino acid residues were encoded by open reading frame and had high identity with homologous sequences from other mammals...
August 2017: Theriogenology
https://www.readbyqxmd.com/read/28594316/effects-of-irisin-and-exercise-on-metabolic-parameters-and-reproductive-hormone-levels-in-high-fat-diet-induced-obese-female-mice
#4
Ercan Bastu, Umit Zeybek, Ebru Gurel Gurevin, Bahar Yüksel Ozgor, Faruk Celik, Nazli Okumus, Irem Demiral, Ozlem Dural, Cem Celik, Huri Bulut, Elif Ilkay Armutak, Bulent Baysal, Faruk Buyru, John Yeh
It has been documented that exogenously administered irisin (10(10) fibronectin-type III domain-containing 5 [FNDC5]), which is a new polypeptide hormone, induces the browning of subcutaneous fat and thermogenesis. In this study, effects of physical activity and exogenous administration of irisin were investigated on parameters related with reproduction and metabolism in the high-fat diet-induced obesity model of the female C57BL/6J mice. Sixty mice were gathered at age approximately 5 to 6weeks and were divided into 3 groups...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28583606/the-influence-of-age-antral-follicle-count-and-diestrous-ovulations-on-estrous-cycle-characteristics-of-mares
#5
Anthony Claes, Barry A Ball, Kirsten E Scoggin, Janet F Roser, Elizabeth M Woodward, Gabriel M Davolli, Edward L Squires, Mats H T Troedsson
Reproductive aging must be well understood to optimize the reproductive management of older mares and to predict their reproductive life-span. The objectives of this study were to: 1) examine age-related differences in follicular dynamics, endocrine profiles, and primordial follicle counts, 2) evaluate the influence of antral follicle count (AFC) on age-related changes in follicular parameters, and 3) determine the influence of diestrous ovulations on the estrous cycle. Young (3-8yr; n = 10), middle-aged (9-18 yr; n = 16), and old (>18 yr; n = 19) light horse mares were examined with transrectal ultrasonography to monitor follicular growth over two consecutive estrous cycles...
July 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28580754/regional-distribution-and-integrity-of-equine-ovarian-pre-antral-follicles
#6
S M Gonzalez, C B da Silva, A G Lindquist, I Bufalo, F Morotti, L A Lisboa, M Seneda
The goal of this study was to determine the distribution of pre-antral follicles in the ovarian parenchyma of mares. For Experiment 1, each ovary was cut longitudinally at the greater curvature, performing two hemiovaries. After that, six fragments from each hemiovary were obtained, resulting in 12 fragments, which were divided into the innermost region of the parenchyma, the middle region and the outermost region. All the three obtained sections were cut transversally to obtain two fragments from each one...
June 4, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28580717/the-development-and-integrity-of-equine-pre-antral-follicles-cultured-in-vitro-with-follicle-stimulating-hormone-fsh-supplementation
#7
M C Max, C B Silva, S M González, A G Lindquist, I Búfalo, R G Gomes, F Morotti, C B Costa, Trr Barreiros, L A Lisboa, M M Seneda
This study investigated the effects of different concentrations of FSH (10, 50, 100 and 200 ng/ml) in supplemented MEM+ on the development of equine pre-antral follicles that were cultured in vitro for 2 or 6 days. The ovaries (n = 5) from mares in seasonal anoestrus were collected from a local abattoir. Ten ovarian tissue fragments of approximately 3 × 3 × 1 mm were obtained from each animal. The fragments were cultured in situ for 2 days (D2) or 6 days (D6) in MEM+ or MEM+ supplemented with FSH at four different concentrations, establishing the following 11 groups: control (D0); MEM + (D2); MEM + (D6); MEM + 10 ng/ml of FSH (D2); MEM + 10 ng/ml of FSH (D6); MEM + 50 ng/ml of FSH (D2); MEM + 50 ng/ml of FSH (D6); MEM + 100 ng/ml of FSH (D2); MEM + 100 ng/ml of FSH (D6); MEM + 200 ng/ml of FSH (D2); and MEM + 200 ng/ml of FSH (D6)...
June 4, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28576861/pharmacological-inhibition-of-the-dna-damage-checkpoint-prevents-radiation-induced-oocyte-death
#8
Vera D Rinaldi, Kristin Hsieh, Robert Munroe, Ewelina M Bolcun-Filas, John C Schimenti
Ovarian function is directly correlated with survival of the primordial follicle reserve. Women diagnosed with cancer have a primary imperative of treating the cancer, but since the resting oocytes are hypersensitive to the DNA-damaging modalities of certain chemo- and radiotherapeutic regimens, such patients face the collateral outcome of premature loss of fertility and ovarian endocrine function. Current options for fertility preservation primarily include collection and cryopreservation of oocytes or in vitro fertilized oocytes, but this necessitates a delay in cancer treatment and additional assisted reproductive technology (ART) procedures...
June 2, 2017: Genetics
https://www.readbyqxmd.com/read/28570923/4-nitrophenol-pnp-inhibits-the-expression-of-estrogen-receptor-%C3%AE-and-disrupts-steroidogenesis-during-the-ovarian-development-in-female-rats
#9
Haolin Zhang, Kazuyoshi Taya, Kentaro Nagaoka, Midori Yoshida, Gen Watanabe
4-nitrophenol (PNP), isolated from diesel exhaust particles, has estrogenic and anti-androgenic activities, and affects the hypothalamus-pituitary-gonad axis in male rats. However, the effect of PNP on the reproduction of the female rats is still unknown. The aim of the study was to investigate the effect of neonatal PNP exposure on the ovarian function of female rats. The neonatal female rats were exposed to PNP (10 mg/kg, subcutaneously injection), the ovary and serum samples were collected at postnatal day (PND) 7, 14 and 21...
May 29, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28569793/oocyte-specific-deletion-of-furin-leads-to-female-infertility-by-causing-early-secondary-follicle-arrest-in-mice
#10
Tie-Gang Meng, Meng-Wen Hu, Xue-Shan Ma, Lin Huang, Qiu-Xia Liang, Yue Yuan, Yi Hou, Hongmei Wang, Heide Schatten, Zhen-Bo Wang, Qing-Yuan Sun
The process of follicular development involves communications between oocyte and surrounding granulosa cells. FURIN is a member of the family of proprotein convertases that is involved in the activation of a large number of zymogens and proproteins by cleavage at its recognition motif. To investigate the functions of FURIN in female fertility, furin(flox/flox) (fur(fl/fl)) mice were crossed with Zp3-Cre mice and Gdf9-Cre, respectively, to achieve oocyte-specific disruption of FURIN. Here we report for the first time that FURIN is dispensable for primordial follicle maintenance and activation but important for early secondary follicular development, as ablation of FURIN in oocytes caused failure of follicle development beyond the type 4 and/or 5a follicles in mutant mice, resulting in increased number of early secondary follicles and the severely decreased number of mature follicles, thus anovulation and infertility...
June 1, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28552778/the-impact-of-zearalenone-on-the-meiotic-progression-and-primordial-follicle-assembly-during-early-oogenesis
#11
Ke-Han Liu, Xiao-Feng Sun, Yan-Zhong Feng, Shun-Feng Cheng, Bo Li, Ya-Peng Li, Wei Shen, Lan Li
Zearalenone (ZEA) is a mycotoxin produced by fusarium graminearum. It can cause abnormal reproductive function by acting as an environmental estrogen. Research has traditionally focused on acute and chronic injury on mammalian reproductive capacity after ZEA treatment. Little research has been done studying the effects of ZEA exposure on early oogenesis. In this study, we investigate the effects of ZEA exposure on meiotic entry, DNA double-strand breaks (DSBs), and primordial follicle assembly during murine early oogenesis...
May 26, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28544226/short-term-rapamycin-treatment-increases-ovarian-lifespan-in%C3%A2-young-and-middle-aged-female-mice
#12
Xiaowei Dou, Yan Sun, Jiazhao Li, Jing Zhang, Dandan Hao, Wenwen Liu, Rui Wu, Feifei Kong, Xiaoxu Peng, Jing Li
Although age-related ovarian failure in female mammals cannot be reversed, recent strategies have focused on improving reproductive capacity with age, and rapamycin is one such intervention that has shown a potential for preserving the ovarian follicle pool and preventing premature ovarian failure. However, the application is limited because of its detrimental effects on follicular development and ovulation during long-term treatment. Herein, we shortened the rapamycin administration to 2 weeks and applied the protocol to both young (8 weeks) and middle-aged (8 months) mouse models...
May 22, 2017: Aging Cell
https://www.readbyqxmd.com/read/28542147/restricting-the-induction-of-ngf-in-ovarian-stroma-engenders-selective-follicular-activation-through-the-mtor-signaling-pathway
#13
Yuanlin He, Xiaoxu Peng, Tinghe Wu, Weijie Yang, Wenwen Liu, Jing Zhang, Yiping Su, Feifei Kong, Xiaowei Dou, Jing Li
In mammalian ovaries, primordial follicles remain in a quiescent state until activation by the surrounding microenvironment. Ovarian intervention, for example, ovarian cystectomy, ovarian wedge resection or laser drilling therapies for polycystic ovarian syndrome, has long been reported to change follicular development by an unknown mechanism(s). Herein, we established a murine model with partial ovarian resection of one ovary unilaterally, with the contralateral ovary undamaged. We found the injury accelerated follicular activation and development through the mTORC1 signaling pathway...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28534450/population-estimate-and-morphometry-of-ovarian-preantral-follicles-from-three-recently-recognized-squirrel-monkey-species-a-comparative-study
#14
Gerson P Lopes, Regiane R Santos, Débora V Almeida, Adriel B Brito, Helder L Queiroz, Sheyla F S Domingues
We describe morphological and morphometrical characteristics of preantral ovarian follicles from three recently recognized Saimiri species: S. macrodon, S. cassiquiarensis and S. vanzolinii; the last one a threatened species. Ovaries from four adult monkeys were evaluated: one pair from a pregnant S. macrodon, two ovarian pairs from S. cassiquiarensis females (one of them pregnant), and one left ovary from a senile S. vanzolinii, applying classical histology. Follicular preantral population was quantified and morphology and morphometry of primordial, primary and secondary follicles were evaluated...
May 23, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28532829/quercetin-supplemented-diet-improves-follicular-development-oocyte-quality-and-reduces-ovarian-apoptosis-in-rabbits-during-summer-heat-stress
#15
Zahid Naseer, Ejaz Ahmad, Erkmen Tuğrul Epikmen, Uğur Uçan, Murat Boyacioğlu, Emrah İpek, Melih Akosy
The present study was designed to test the modulatory effect of dietary quercetin on follicle population, apoptosis, in vitro maturation rate and quality of oocytes in heat stressed female rabbits. A total of thirty-four New Zealand White heat stress (HS) exposed female rabbits were either fed with quercetin supplemented diet (QU-HS) or non-supplemented (HS) diet. Firstly, laparotomy was performed for oocyte retrieval and then, oocyte grading and COCs dimensional assessments were conducted. The A and B-grade oocytes were submitted for in vitro maturation...
July 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28529453/the-role-of-germ-cell-loss-during-primordial-follicle-assembly-a-review-of-current-advances
#16
REVIEW
Yuan-Chao Sun, Xiao-Feng Sun, Paul W Dyce, Wei Shen, Hong Chen
In most female mammals, early germline development begins with the appearance of primordial germ cells (PGCs), and develops to form mature oocytes following several vital processes. It remains well accepted that significant germ cell apoptosis and oocyte loss takes place around the time of birth. The transition of the ovarian environment from fetal to neonatal, coincides with the loss of germ cells and the timing of follicle formation. All told it is common to lose approximately two thirds of germ cells during this transition period...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28528322/very-low-doses-of-heavy-oxygen-ion-radiation-induce-premature-ovarian-failure
#17
Birendra Mishra, Ryan Ripperdan, Laura Ortiz, Ulrike Luderer
Astronauts are exposed to charged particles during space travel, and charged particles are also used for cancer radiotherapy. Premature ovarian failure is a well-known side effect of conventional, low linear energy transfer (LET) cancer radiotherapy, but little is known about the effects of high LET charged particles on the ovary. We hypothesized that lower LET (16.5 keV/µm) oxygen particles would be less damaging to the ovary than we previously found for iron (LET = 179 keV/µm). Adult female mice were irradiated with 0, 5, 30 or 50 cGy oxygen ions or 50 cGy oxygen plus dietary supplementation with the antioxidant alpha lipoic acid (ALA)...
August 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28512792/expression-of-aquaporin-4-in-the-chicken-ovary-in-relation-to-follicle-development
#18
M Nowak, M Grzesiak, N Saito, M Kwaśniewska, A Sechman, A Hrabia
In the mammalian ovary, aquaporins (AQPs) are thought to be involved in the regulation of fluid transport within the follicular wall and antrum formation. Data concerning the AQPs in the avian ovary is very limited. Therefore, the present study was designed to examine whether the AQP4 is present in the chicken ovary, and if so, what is its distribution in the ovarian compartment of the laying hen. Localization of AQP4 in the ovarian follicles at different stage of development was also investigated. After decapitation of hens the stroma with primordial follicles and white (1-4 mm), yellowish (4-8 mm), small yellow and the three largest yellow pre-ovulatory follicles F3-F1 (F3 < F2 < F1; 20-36 mm) were isolated from the ovary...
May 16, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28511863/expression-of-tnf-%C3%AE-system-members-in-bovine-ovarian-follicles-and-the-effects-of-tnf-%C3%AE-or-dexamethasone-on-preantral-follicle-survival-development-and-ultrastructure-in-vitro
#19
A W B Silva, R P Ribeiro, V G Menezes, R S Barberino, J R S Passos, A M P Dau, J J N Costa, L R F Melo, F T G Bezerra, M A M Donato, C A Peixoto, M H T Matos, P B D Gonçalves, R van den Hurk, J R V Silva
This study was conducted to detect the protein expression of TNF-α system members (TNF-α/TNFR1/TNFR2) in bovine ovarian follicles and to evaluate the effects of TNF-α or dexamethasone on the survival and growth of primordial follicles in vitro, as well as on gene expression in cultured ovarian tissue. It was hypothesized that TNF-α induces follicular atresia in ovarian tissues cultured in vitro, and that dexamethasone suppresses the production of endogenous TNF-α, which can improve follicle viability in vitro...
May 6, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28502659/apc-c-cdh1-enables-removal-of-shugoshin-2-from-the-arms-of-bivalent-chromosomes-by-moderating-cyclin-dependent-kinase-activity
#20
Ahmed Rattani, Randy Ballesteros Mejia, Katherine Roberts, Maurici B Roig, Jonathan Godwin, Michael Hopkins, Manuel Eguren, Luis Sanchez-Pulido, Elwy Okaz, Sugako Ogushi, Magda Wolna, Jean Metson, Alberto M Pendás, Marcos Malumbres, Béla Novák, Mary Herbert, Kim Nasmyth
In mammalian females, germ cells remain arrested as primordial follicles. Resumption of meiosis is heralded by germinal vesicle breakdown, condensation of chromosomes, and their eventual alignment on metaphase plates. At the first meiotic division, anaphase-promoting complex/cyclosome associated with Cdc20 (APC/C(Cdc20)) activates separase and thereby destroys cohesion along chromosome arms. Because cohesion around centromeres is protected by shugoshin-2, sister chromatids remain attached through centromeric/pericentromeric cohesin...
May 22, 2017: Current Biology: CB
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