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https://www.readbyqxmd.com/read/29787998/repeated-superovulation-increases-the-risk-of-osteoporosis-and-cardiovascular-diseases-by-accelerating-ovarian-aging-in-mice
#1
Jinjin Zhang, Zhiwen Lai, Liangyan Shi, Yong Tian, Aiyue Luo, Zheyuan Xu, Xiangyi Ma, Shixuan Wang
Superovulation procedures and assisted reproductive technologies have been widely used to treat couples who have infertility problems. Although generally safe, the superovulation procedures are associated with a series of complications, such as ovarian hyper-stimulation syndrome, thromboembolism, and adnexal torsion. The role of long-term repeated superovulation in ovarian aging and especially in associated disorders such as osteoporosis and cardiovascular diseases is still unclear. In this study, we sought to determine if repeated superovulation by ten cycles of treatment with pregnant mare serum gonadotropin/human chorionic gonadotropin could affect ovarian reserve, ovarian function, bone density and heart function...
May 22, 2018: Aging
https://www.readbyqxmd.com/read/29778393/fertility-preservation-in-pediatric-female-cancer-patients
#2
Sara E Arian, Rebecca L Flyckt, Richard Herman, Hadi Erfani, Tommaso Falcone
OBJECTIVE: To describe and demonstrate ovarian tissue cryopreservation (OTC) as an emerging fertility preservation technique DESIGN: Video presentation. SETTING: University hospital. PATIENT(S): A 6 year-old female patient diagnosed with aplastic anemia with plan for bone marrow transplantation underwent laparoscopic unilateral oophorectomy in conjunction with surgical procedure for port placement by the pediatric surgeon, followed by cryopreservation of ovarian tissue...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29755030/detrimental-effect-of-hypericum-perforatum-on-ovarian-functions
#3
Buket Demirci, Fadime Kahyaoğlu, Tolga Atakul, Mustafa Yılmaz, Yavuz Özoran
OBJECTIVE: Hypericum perforatum (HP) is widely used for depression and distress treatment as an over-the-counter plant in any age. This study investigated the safety of HP on ovarian functions and infertility. MATERIAL AND METHODS: HP given to the rats in two different doses (100 and 300 mg/kg/day) with drinking water for four weeks. Half of the treatment groups have been sacrificed at the end of four weeks intervention, remained have been sacrificed after additional waiting period for four weeks to see reversibility if there is...
May 14, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29743337/oocyte-quality-control-causes-mechanisms-and-consequences
#4
Neil Hunter
Oocyte quality and number are key determinants of reproductive life span and success. These variables are shaped in part by the elimination of oocytes that experience problems during the early stages of meiosis. Meiotic prophase-I marks an extended period of genome vulnerability in which epigenetic reprogramming unleashes retroelements and hundreds of DNA double-strand breaks (DSBs) are inflicted to initiate the programmed recombination required for accurate chromosome segregation at the first meiotic division...
May 9, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29725001/ablation-of-beta-subunit-of-protein-kinase-ck2-in-mouse-oocytes-causes-follicle-atresia-and-premature-ovarian-failure
#5
Qiu-Xia Liang, Zhen-Bo Wang, Fei Lin, Chun-Hui Zhang, Hong-Mei Sun, Liang Zhou, Qian Zhou, Heide Schatten, Filhol-Cochet Odile, Boldyreff Brigitte, Qing-Yuan Sun, Wei-Ping Qian
Premature ovarian failure (POF), a major cause of female infertility, is a complex disorder, but the molecular mechanisms underlying the disorder are only poorly understood. Here we report that protein kinase CK2 contributes to maintaining follicular survival through PI3K/AKT pathway and DNA damage response pathway. Targeted deletion of CK2β in mouse oocytes from the primordial follicle stage resulted in female infertility, which was attributed to POF incurring by massive follicle atresia. Downregulated PI3K/AKT signaling was found after CK2β deletion, indicated by reduced level of phosphorylated AKT (S473, T308, and S129) and altered AKT targets related to cell survival...
May 3, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29721205/treosulfan-induces-distinctive-gonadal-toxicity-compared-with-busulfan
#6
Mattan Levi, Salomon M Stemmer, Jerry Stein, Ruth Shalgi, Irit Ben-Aharon
Treosulfan (L-treitol-1,4-bis-methanesulfonate) has been increasingly incorporated as a main conditioning protocol for hematopoietic stem cell transplantation in pediatric malignant and non-malignant diseases. Treosulfan presents lower toxicity profile than other conventional alkylating agents containing myeloablative and immunosuppressive traits such as busulfan. Yet, whereas busulfan is considered highly gonadotoxic, the gonadal toxicity profile of treosulfan remains to be elucidated. To study the gonadotoxicity of treosulfan, pubertal and prepubertal male and female mice were injected with treosulfan or busulfan and sacrificed one week, one month or six months later...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29696926/-protective-effects-of-electroacupuncture-pretreatment-on-ovarian-in-rats-with-premature-ovarian-insufficiency
#7
Weiming Wang, Yang Wang, Jiani Wu, Likun Yang, Zhishun Liu
OBJECTIVE: To explore the protective effect and possible mechanism of electroacupuncture (EA) pretreatment at "Zhongliao" (BL 33) and "Tianshu" (ST 25) on ovarian in rats with premature ovarian insufficiency (POI). METHODS: A total of 32 SD female rats with regular estrus were randomly divided into a blank group, a model group, an EA group and an immobilization group, 8 rats in each one. The rats in the model group, EA group and immobilization group were treated with intraperitoneal injection of 4-vinylcyclohexene diepoxide (160 mg/kg) for 15 days to establish the model...
April 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29695822/dacarbazine-depletes-the-ovarian-reserve-in-mice-and-depletion-is-enhanced-with-age
#8
Amy L Winship, Monika Bakai, Urooza Sarma, Seng H Liew, Karla J Hutt
Dacarbazine is commonly administered for the treatment of cancers prevalent in reproductive age females. However, investigations of off-target effects of dacarbazine on the ovary are limited. We assessed the impact of dacarbazine on the ovarian reserve of primordial follicles, essential for fertility. Eight week and 6 month old C57BL/6 J mice were administered with dacarbazine or saline on day (d)0 and d7, then sacrificed after 12 hours (h), or 14d (n = 4-5/group). Follicle numbers, follicle density, serum AMH and corpora lutea were quantified and estrous cyclicity monitored...
April 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29685707/supplemental-flaxseed-modulates-ovarian-functions-of-weanling-gilts-via-the-action-of-selected-fatty-acids
#9
Radoslava Vlčková, Zuzana Andrejčáková, Drahomíra Sopková, Zdenka Hertelyová, Katarzyna Kozioł, Marek Koziorowski, Soňa Gancarčíková
The aim of this study was to examine the influence of dietary flaxseed on the endocrine and ovarian functions of weanling gilts challenged with E. coli and Coronavirus infections treated with dietary probiotic cheeses and to understand the possible mechanisms of its effects on ovarian function. Probiotics were used as a natural substitution for antibiotics and 10% dietary flaxseed is an effective prebiotic which supports the action of probiotics and has other beneficial effects on the organism. Probiotics with or without flaxseed were fed to weanling gilts starting 10 days before and lasting up until 14 days after weaning...
April 18, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29670080/starvation-during-pregnancy-impairs-fetal-oogenesis-and-folliculogenesis-in-offspring-in-the-mouse
#10
Jun-Jie Wang, Xiao-Wei Yu, Rui-Ying Wu, Xiao-Feng Sun, Shun-Feng Cheng, Wei Ge, Jing-Cai Liu, Ya-Peng Li, Jing Liu, Shu-Hua Zou, Massimo De Felici, Wei Shen
Although it is becoming increasingly evident that maternal starvation during pregnancy can have permanent effects on a range of physiological processes in the offspring, scant information is available about the consequence of such condition for oogenesis and hence for lifetime reproductive success of progeny in mammals. In the present study, we address this topic by starving pregnant mice at the time of ovarian differentiation (12.5 days post coitum (dpc)) for three consecutive days and analyzed the consequence first on the survival of the fetal oocytes and their capability to progress throughout the stages of meiotic prophase I (MPI) and then on the postnatal folliculogenesis of the offspring...
April 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29667147/effects-of-heyan-kuntai-capsule-on-follicular-development-and-oocyte-cohesin-levels-in-aged-mice
#11
Bin Zhang, Nan Chu, Xue-Min Qiu, Wei Tang, Hans-Jürgen Gober, Da-Jin Li, Ling Wang
OBJECTIVE: To evaluate the effect of Heyan Kuntai Capsule (, HYKT) on the ovarian function of aged mice and expressions of cohesion complexes in oocytes. METHODS: Twenty-five 9-month-old female C57BL/6J mice were randomly divided into 5 groups by block randomization method (n=5 per group), including the control group (saline), 17 β-estradiol group [E2 , 100 μg/(kg·d)], and low-, medium-, and high-dose of HYKT groups [0.3, 0.9, 2.7 g/(kg·d), respectively]. All mice were treated by intragastric administration for 4 weeks...
April 17, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29660627/positive-effect-of-resveratrol-against-preantral-follicles-degeneration-after-ovarian-tissue-vitrification
#12
Carina Diniz Rocha, Mayara Mafra Soares, Deize de Cássia Antonino, Jairo Melo Júnior, Renata Ferreira Freitas Mohallem, Ana Paula Ribeiro Rodrigues, José Ricardo Figueiredo, Marcelo Emílio Beletti, José Octavio Jacomini, Benner Geraldo Alves, Kele Amaral Alves
This study aimed to evaluate whether the addition of resveratrol to vitrification/thawing medium improves the cryotolerance of preantral follicles enclosed in bovine ovarian fragments. Ovarian fragments were obtained from bovine fetuses and distributed to the following groups: fresh ovarian fragments (control), vitrified (VIT), and vitrified with resveratrol (VIT + RESV). Overall, the mean percentage of normal follicles was greater (P < 0.05) in the VIT + RESV compared to the VIT group. Moreover, the probability of finding normal follicles was 2...
April 6, 2018: Theriogenology
https://www.readbyqxmd.com/read/29615536/protective-effects-of-melatonin-against-nicotine-induced-disorder-of-mouse-early-folliculogenesis
#13
Yu-Feng Wang, Xiao-Feng Sun, Ze-Li Han, Lan Li, Wei Ge, Yong Zhao, Massimo De Felici, Wei Shen, Shun-Feng Cheng
In this paper, we show that neonatal mice injected for five consecutive days with nicotine display impaired germ cell cyst breakdown and primordial follicle assembly resulting in decreased ovarian reserve lasting until sex maturation age. The effects of nicotine on the pups ovaries were associated with decreased expression of oocyte specific genes such as Nobox , Lhx8 , Figlα and Sohlh2 . Moreover, the ovaries of pups injected with nicotine showed increased level of cell oxidative stress and autophagic markers (upregulation of AMPKα-1, increased ratio LC3-II/LC3-I, downregulation of AKT and mTOR)...
March 28, 2018: Aging
https://www.readbyqxmd.com/read/29609766/dienogest-suppresses-the-activation-of-primordial-follicles-and-preserves-the-primordial-follicle-stockpile-for-fertility-in-mice
#14
Luyi Zheng, Fuminori Kimura, Di Wu, Aina Morimune, Yoko Niwa, Shizuka Mita, Kentaro Takahashi, Takashi Murakami
The aim of the present study was to characterize the effect of long-term usage of dienogest, a fourth-generation progestin that possesses progestogen and anti-androgen activities, on the stockpile of oocytes and fertility after administration. Female ICR mice (100 days old) were divided into a dienogest group and a control group. The mice received 16 consecutive subcutaneous injections of 5 mg dienogest dissolved in corn oil or corn oil as a vehicle control every 4 days. The mice treated with dienogest had more total offspring and larger litter sizes after the final administration than the mice treated with the vehicle control...
April 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29607457/preliminary-human-application-of-optical-coherence-tomography-for-quantification-and-localization-of-primordial-follicles-aimed-at-effective-ovarian-tissue-transplantation
#15
Seido Takae, Kosuke Tsukada, Ichiro Maeda, Naoki Okamoto, Yorino Sato, Haruhiro Kondo, Kiemi Shinya, Yuki Motani, Nao Suzuki
PURPOSE: The purpose of this study was to evaluate the possible clinical application of optical coherence tomography for assessing ovarian reserve in individual specimens of human ovarian tissue for fertility preservation. METHODS: Ovarian tissue examination by optical coherence tomography was performed before ovarian tissue cryopreservation. Three of the four subjects had hematological disease or cancer, and they faced a threat to their fertility due to impending chemotherapy...
April 2, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29601583/chronic-restraint-stress-induces-excessive-activation-of-primordial-follicles-in-mice-ovaries
#16
Minhua Xu, Junyan Sun, Qian Wang, Qiuwan Zhang, Chunsheng Wei, Dongmei Lai
Chronic stress is an important factor influencing people's health. It usually causes endocrinal disorders and a decline in reproduction in females. Although studies of both human and animals suggest a detrimental effect of stress on reproduction, the influence of chronic stress on the ovarian reservation and follicular development is still not clear. In this study, a chronic restraint stress (CRS) mouse model was used to investigate the effect of stress on ovarian reservation and follicular development and explore the underlying mechanism...
2018: PloS One
https://www.readbyqxmd.com/read/29589294/examination-of-the-ovotoxicity-of-5-fluorouracil-in-mice
#17
M Lambouras, S H Liew, K Horvay, H E Abud, J M Stringer, Karla J Hutt
PURPOSE: Undesirable side effects of cancer treatments are common and include damage to the ovary, and depletion of the follicle reserve, which if severe enough, can lead to infertility and early menopause. Antimetabolite drugs, such as 5-fluorouracil (5-FU), are not considered to be detrimental to the ovary, but the ovotoxicity of 5-FU has not been evaluated in any detail. The purpose of this study was to evaluate the effects of 5-FU on follicle number. METHODS: In this study, adult female C57Bl6 mice (n = 4-6 animals/group) received a single dose of saline or 5-FU (150 mg/kg) and markers of ovarian damage and follicle depletion were assessed 12 h and 7 days later...
March 27, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29581237/female-fertility-preservation-past-present-and-future
#18
Benjamin Fisch, Ronit Abir
Anti-cancer therapy, particularly chemotherapy damages ovarian follicles and promotes ovarian failure. The only pharmacological means for protecting the ovaries from chemotherapy-induced injury is gonadotrophin-releasing hormone agonist, but its efficiency remains controversial; ovarian transposition is used to shield the ovary from radiation when indicated. Until the late 1990s, the only option for fertility preservation and restoration in women with cancer was embryo cryopreservation. The development of other assisted reproductive technologies such as mature oocyte cryopreservation and in vitro maturation of oocytes has contributed to fertility preservation...
March 26, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29548867/ovotesticular-disorder-of-sex-development-presenting-as-an-acute-scrotum
#19
Seyed Ali Mirshahvalad, Paria Alinia, Pooya Hekmati, Nahid Nafisi, Abdol-Mohammad Kajbafzadeh
Hermaphroditism is known as ovotesticular disorder of sex development. A 14-year-old boy was admitted with right acute scrotum. Exploration revealed tunica rupture and hematoma, with no viable tissue. After 1 month, he was admitted again with left hemiscrotal pain. Microscopic examination of the left gonad demonstrated foci of hemorrhagic cysts, primordial follicles, and regions of seminiferous tubules. We preserved a testicular tissue and the ovarian part was extracted completely. Long-term follow-up with his hormonal profile is reported...
March 13, 2018: Urology
https://www.readbyqxmd.com/read/29546669/transplantation-of-uc-mscs-on-collagen-scaffold-activates-follicles-in-dormant-ovaries-of-pof-patients-with-long-history-of-infertility
#20
Lijun Ding, Guijun Yan, Bin Wang, Lu Xu, Yan Gu, Tong Ru, Xiaoying Cui, Lei Lei, Jingyu Liu, Xiaoqiang Sheng, Bin Wang, Chunxue Zhang, Yanjun Yang, Ruiwei Jiang, Jianjun Zhou, Na Kong, Feifei Lu, Huaijun Zhou, Yannan Zhao, Bing Chen, Yali Hu, Jianwu Dai, Haixiang Sun
Premature ovarian failure (POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study, umbilical cord mesenchymal stem cells on a collagen scaffold (collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles...
March 13, 2018: Science China. Life Sciences
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