keyword
https://read.qxmd.com/read/38492011/change-in-systemic-steroid-use-and-surgery-rate-in-patients-with-inflammatory-bowel-disease-a-japanese-real-world-database-analysis
#21
JOURNAL ARTICLE
Daisuke Hirayama, Shinichiro Hyodo, Kazuo Morita, Hiroshi Nakase
BACKGROUND: Corticosteroids are recommended only for induction of remission in inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD). This study aimed to evaluate the change in pharmacologic treatment use, particularly systemic corticosteroids, over approximately 30 years, and the impact of biologics on IBD treatment since their appearance in the 2000s. METHODS: This retrospective study conducted in Japan used data from the Phoenix cohort database (January 1990 to March 2021)...
March 16, 2024: Journal of Gastroenterology
https://read.qxmd.com/read/38491444/trends-in-pre-hospital-volume-resuscitation-of-blunt-trauma-patients-a-15-year-analysis-of-the-british-tarn-and-german-traumaregister-dgu%C3%A2-national-registries
#22
JOURNAL ARTICLE
M F Bath, J Schloer, J Strobel, W Rea, R Lefering, M Maegele, H De'Ath, Z B Perkins
INTRODUCTION: Fluid resuscitation has long been a cornerstone of pre-hospital trauma care, yet its optimal approach remains undetermined. Although a liberal approach to fluid resuscitation has been linked with increased complications, the potential survival benefits of a restrictive approach in blunt trauma patients have not been definitively established. Consequently, equipoise persists regarding the optimal fluid resuscitation strategy in this population. METHODS: We analysed data from the two largest European trauma registries, the UK Trauma Audit and Research Network (TARN) and the German TraumaRegister DGU® (TR-DGU), between 2004 and 2018...
March 15, 2024: Critical Care: the Official Journal of the Critical Care Forum
https://read.qxmd.com/read/38491433/effect-of-online-infographics-for-enhancing-health-literacy-among-patients-with-type-2-diabetes-in-primary-care-unit-during-the-covid-19-pandemic-a-randomized-controlled-trial
#23
JOURNAL ARTICLE
Suchada Sutthiworapon, Polathep Vichitkunakorn, Kittisakdi Choomalee, Pitchayanont Ngamchaliew
BACKGROUND: Health literacy (HL) in patients with type 2 diabetes mellitus (DM) can help control disease and prevent complications. However, most patients with type 2 DM have inadequate HL; therefore, their HL must be further improved. This study aimed to determine the effects of online infographics on improving HL among patients with type 2 DM. METHODS: This randomized controlled trial was conducted from July 2022 to September 2022, at the primary care unit of Songklanagarind Hospital, Thailand; 30 patients with type 2 DM were randomly assigned to the experimental (n = 15; three types of infographics) and control (n = 15; three types of pamphlets) groups...
March 15, 2024: BMC Prim Care
https://read.qxmd.com/read/38491387/characteristics-of-the-oral-and-gastric-microbiome-in-patients-with-early-stage-intramucosal-esophageal-squamous-cell-carcinoma
#24
JOURNAL ARTICLE
Han Chen, Xingzhou Jiang, Fengyi Zhu, Ruoyun Yang, Xin Yu, Xiaoying Zhou, Nana Tang
BACKGROUND: Oral microbiome dysbacteriosis has been reported to be associated with the pathogenesis of advanced esophageal cancer. However, few studies investigated the potential role of oral and gastric microbiota in early-stage intramucosal esophageal squamous carcinoma (EIESC). METHOD: A total of 104 samples were collected from 31 patients with EIESC and 21 healthy controls. The compositions of oral and gastric microbiota were analyzed using 16 S rRNA V3-V4 amplicon sequencing...
March 15, 2024: BMC Microbiology
https://read.qxmd.com/read/38491267/outcomes-of-venous-thromboembolism-in-patients-with-inherited-thrombophilia-treated-with-direct-oral-anticoagulants-insights-from-the-riete-registry
#25
JOURNAL ARTICLE
Omri Cohen, Gili Kenet, Sarina Levy-Mendelovich, Inna Tzoran, Benjamin Brenner, Cristina De Ancos, Patricia López-Miguel, José F Varona, Judith Catella, Manuel Monreal
While direct oral anticoagulants (DOACs) are frequently used to treat venous thromboembolism (VTE), the outcomes of patients with inherited thrombophilia (IT) receiving DOACs for VTE remain understudied. We used data from the international RIETE registry to compare the rates of VTE recurrences, major bleeding, and mortality during anticoagulant treatment in VTE patients with and without IT, grouped by the use of DOACs or standard anticoagulant therapy. Among 103,818 enrolled patients, 21,089 (20.3%) were tested for IT, of whom 8422 (39...
March 16, 2024: Journal of Thrombosis and Thrombolysis
https://read.qxmd.com/read/38491198/treosulfan-compared-to-busulfan-in-allogeneic-haematopoietic-stem-cell-transplantation-for-myelofibrosis-a-registry-based-study-from-the-chronic-malignancies-working-party-of-the-ebmt
#26
JOURNAL ARTICLE
Marie Robin, Simona Iacobelli, Linda Koster, Jakob Passweg, Daniele Avenoso, Keith M O Wilson, Urpu Salmenniemi, Peter Dreger, Peter von dem Borne, John A Snowden, Stephen Robinson, Maria Chiara Finazzi, Thomas Schroeder, Matthew Collin, Matthias Eder, Edouard Forcade, Michael Loschi, Stefania Bramanti, Jose Antonio Pérez-Simón, Tomasz Czerw, Nicola Polverelli, Joanna Drozd-Sokolowska, Kavita Raj, Juan Carlos Hernández-Boluda, Donal P McLornan
We aimed to compare outcomes following treosulfan (TREO) or busulfan (BU) conditioning in a large cohort of myelofibrosis (MF) patients from the EBMT registry. A total of 530 patients were included; 73 received TREO and 457 BU (BU ≤ 6.4 mg/kg in 134, considered RIC, BU > 6.4 mg/kg in 323 considered higher dose (HD)). Groups were compared using adjusted Cox models. Cumulative incidences of engraftment and acute GVHD were similar across the 3 groups. The TREO group had significantly better OS than BU-HD (HR:0...
March 15, 2024: Bone Marrow Transplantation
https://read.qxmd.com/read/38491173/prognostic-factors-of-renal-cell-cancer-in-elderly-patients-a-population-based-cohort-study
#27
JOURNAL ARTICLE
Heini Pajunen, Thea Veitonmäki, Heini Huhtala, Jussi Nikkola, Antti Pöyhönen, Teemu Murtola
Mortality in renal cell cancer (RCC) is high in the elderly population. Comorbidities have a greater impact on overall prognosis of RCC among elderly patients than in younger patients. All new RCC cases were collected in people over 74 years of age between 1995 and 2018 from the Finnish cancer registry. The comorbidities were identified from the Care Registry for Healthcare. Charlson Comorbidity Index (CCI) was used to evaluate the risk of death based on comorbidities. The overall risk of death was analyzed using the Cox regression model...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38491111/efficacy-and-safety-of-durable-versus-biodegradable-polymer-drug-eluting-stents-in-patients-with-acute-myocardial-infarction-complicated-by-cardiogenic-shock
#28
JOURNAL ARTICLE
Woo Jin Jang, Ik Hyun Park, Ju Hyeon Oh, Ki Hong Choi, Young Bin Song, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Chul-Min Ahn, Cheol Woong Yu, Hyun-Joong Kim, Jang-Whan Bae, Sung Uk Kwon, Hyun Jong Lee, Wang Soo Lee, Jin-Ok Jeong, Sang-Don Park, Jeong Hoon Yang
The clinical impact of different polymer technologies in newer-generation drug-eluting stents (DESs) for patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS) remains poorly understood. We investigated the efficacy and safety of durable polymer DESs (DP-DESs) compared with biodegradable polymer DESs (BP-DESs). A total of 620 patients who underwent percutaneous coronary intervention with newer-generation DESs for AMI complicated by CS was divided into two groups based on polymer technology: the DP-DES group (n = 374) and the BP-DES group (n = 246)...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38491090/early-menopause-is-associated-with-abnormal-diastolic-function-and-poor-clinical-outcomes-in-women-with-suspected-angina
#29
JOURNAL ARTICLE
SungA Bae, Seong-Mi Park, So Ree Kim, Mi-Na Kim, Dong-Hyuk Cho, Hee-Dong Kim, Hyun Ju Yoon, Myung-A Kim, Hack-Lyoung Kim, Kyung-Soon Hong, Mi-Seung Shin, Jin-Ok Jeong, Wan-Joo Shim
Early identification of women at high risk for cardiovascular diseases (CVD), with subsequent monitoring, will allow for improved clinical outcomes and generally better quality of life. This study aimed to identify the associations between early menopause, abnormal diastolic function, and clinical outcomes. This retrospective study included 795 menopausal women from is a nationwide, multicenter, registry of patients with suspected angina visiting outpatient clinic. The patients into two groups: early and normal menopause (menopausal age ≤ 45 and > 45 years, respectively)...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38491043/polygenic-risk-score-based-prediction-of-breast-cancer-risk-in-taiwanese-women-with-dense-breast-using-a-retrospective-cohort-study
#30
JOURNAL ARTICLE
Chih-Chiang Hung, Sin-Hua Moi, Hsin-I Huang, Tzu-Hung Hsiao, Chi-Cheng Huang
Mammographic screening has contributed to a significant reduction in breast cancer mortality. Several studies have highlighted the correlation between breast density, as detected through mammography, and a higher likelihood of developing breast cancer. A polygenic risk score (PRS) is a numerical score that is calculated based on an individual's genetic information. This study aims to explore the potential roles of PRS as candidate markers for breast cancer development and investigate the genetic profiles associated with clinical characteristics in Asian females with dense breasts...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38490937/impact-of-left-ventricular-ejection-fraction-and-aortic-valve-gradient-on-mortality-following-transcatheter-aortic-valve-intervention
#31
JOURNAL ARTICLE
Ian C Gilchrist, Smadar Kort, Ting-Yu Wang, Henry Tannous, Robert Pyo, Ely Gracia, Thomas Bilfinger, Hal A Skopicki, Puja B Parikh
BACKGROUND: Data regarding the impact of reduced left ventricular ejection fraction (LVEF) and/or reduced mean aortic valve gradient (AVG) on outcomes following transcatheter aortic valve intervention (TAVI) have been conflicting. We sought to assess the relationship between LVEF, AVG, and 1-year mortality in patients undergoing TAVI. METHODS: We prospectively evaluated 298 consecutive adults undergoing TAVI from 2015 to 2018 at an academic tertiary medical center...
March 7, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38490851/functional-outcome-and-associations-with-prehospital-time-and-urban-remote-disparities-in-trauma-a-norwegian-national-population-based-study
#32
JOURNAL ARTICLE
Imw Nilsbakken, T Wisborg, S Sollid, E Jeppesen
BACKGROUND: There is a lack of knowledge regarding the functional outcomes of patients after trauma. Remote areas in Norway has been associated with an increased risk of trauma-related mortality. However, it is unknown how this might influence trauma-related morbidity. The aim of this study was to assess the functional outcomes of patients in the Norwegian trauma population and the relationship between prehospital time and urban-remote disparities on functional outcome. METHODS: This registry-based study included 34,611 patients from the Norwegian Trauma Registry from 2015 - 2020...
March 5, 2024: Injury
https://read.qxmd.com/read/38490850/epidemiology-and-factors-associated-with-mortality-among-pediatric-major-trauma-patients-in-nova-scotia-a-17-year-retrospective-analysis
#33
JOURNAL ARTICLE
Andrea Sadoway, Renee Kinden, Mete Erdogan, Nelofar Kureshi, Michelle Johnson, Robert S Green, Jason G Emsley
BACKGROUND: Major traumatic injury in the pediatric population requires further evaluation to improve patient outcomes. Relatively few Canadian studies have investigated pediatric trauma using population-based data. Our objectives were to describe the epidemiology of pediatric major trauma in Nova Scotia and identify factors associated with in-hospital mortality. METHODS: Retrospective cohort study of pediatric major trauma patients (age <18 years) injured in Nova Scotia over a 17-year period (April 2001-March 2018)...
March 5, 2024: Injury
https://read.qxmd.com/read/38490848/nationwide-study-on-open-tibial-fractures-in-the-netherlands-incidence-demographics-and-level-of-hospital-care
#34
JOURNAL ARTICLE
M P Noorlander-Borgdorff, A Şekercan, D A Young-Afat, M Bouman, M Botman, G F Giannakópoulos
OBJECTIVES: Open tibial fractures are relatively common injuries following traffic accidents. The vulnerability of the soft tissues surrounding the tibia increases the susceptibility to complications, including infection and nonunion. To minimize complications, a multidisciplinary, timely approach is crucial. To date, the Dutch incidence and level of hospital treatment remain unknown due to a lack of condition-specific nationwide registries. This study aimed to estimate the incidence and management of open tibial fractures in the Netherlands, providing essential information for public health policymaking and guideline development...
March 3, 2024: Injury
https://read.qxmd.com/read/38490766/providing-hematopoietic-stem-cell-products-from-unrelated-donors-to-the-world-dkms-donor-centers-and-dkms-registry
#35
REVIEW
Alexander H Schmidt, Jürgen Sauter, Johannes Schetelig, Elke Neujahr, Julia Pingel
Allogeneic hematopoietic stem cell (HSC) transplantation is a curative therapy for many severe blood diseases. As many patients have no suitable family donor, large unrelated donor registries and donor centers have been established in many countries, along with an international system for the provision of unrelated donor HSC products. As an essential part of this system, DKMS operates donor centers in 7 countries with a total of 12.2 million donors and over 114,000 donations so far, and a multinational donor registry...
March 2024: Best Practice & Research. Clinical Haematology
https://read.qxmd.com/read/38490656/adjuvant-chemotherapy-and-survival-outcomes-in-older-women-with-hr-her2-breast-cancer-a-propensity-score-matched-retrospective-cohort-study-using-the-seer-database
#36
JOURNAL ARTICLE
Xindi Ma, Shang Wu, Xiangmei Zhang, Nannan Chen, Chenhui Yang, Chao Yang, Miao Cao, Kaiye Du, Yunjiang Liu
OBJECTIVES: This study aimed to investigate the impact of adjuvant chemotherapy (ACT) on survival outcomes in older women with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer (BC). DESIGN: A retrospective cohort study using data from the Surveillance, Epidemiology, and End Results database, which contains publicly available information from US cancer registries. SETTING AND PARTICIPANTS: The study included 45 762 older patients with BC aged over 65 years diagnosed between 2010 and 2015...
March 15, 2024: BMJ Open
https://read.qxmd.com/read/38490356/clinical-performance-of-the-low-profile-zenith-alpha-abdominal-endovascular-graft-2-year-results-from-the-zephyr-registry
#37
JOURNAL ARTICLE
Johannes Hatzl, Michiel van Basten Batenburg, Kak K Yeung, Bram Fioole, Eric Verhoeven, Geert Lauwers, Tilo Kölbel, Jan J Wever, Dierk Scheinert, Wouter Van den Eynde, Guido Rouhani, Barend M E Mees, Frank Vermassen, Hubert Schelzig, Dittmar Böckler, Philippe W M Cuypers
OBJECTIVE: The midterm outcomes of the low profile Zenith Alpha Abdominal Endovascular Graft from the ZEnith alPHa for aneurYsm Repair (ZEPHYR) registry are reported. METHODS: The ZEPHYR registry is a physician initiated, multicentre, non-randomised, core laboratory controlled, prospective registry. Inclusion criteria were patients with non-ruptured abdominal aortic aneurysm with a maximum diameter ≥ 50 mm or enlargement > 5 mm within 6 months, with a site reported infrarenal neck length of ≥ 10 mm and with the intention to electively implant the Zenith Alpha abdominal endograft...
March 13, 2024: European Journal of Vascular and Endovascular Surgery
https://read.qxmd.com/read/38490270/renal-impairment-and-outcome-in-takotsubo-syndrome-insights-from-a-national-multicentric-cohort
#38
JOURNAL ARTICLE
Ravi Vazirani, Manuel Almendro Delia, Emilia Blanco-Ponce, Agustín C Martín-García, Clara Fernández-Cordón, Aitor Uribarri, Mireia Andrés, Oscar Vedia, Alessandro Sionis, Miguel Corbí-Pascual, Jorge Salamanca, Alberto Pérez-Castellanos, José David Martínez Carmona, Sergio Raposeiras, David Aritza-Conty, Javier Lopez-País, Marta Guillén-Marzo, Carmen Lluch-Requerey, Juan Manuel Escudier, Manuel Martínez-Sellés, Iván J Núñez-Gil
INTRODUCTION: Data on the association between kidney function and Takotsubo syndrome (TTS) outcomes are scarce and conflictive. OBJECTIVE: To assess the impact of chronic kidney disease (CKD) and acute renal failure (ARF) in patients with TTS. MATERIAL AND METHODS: Patients from the prospective nation-wide (RETAKO) registry were included and divided into quartiles of maximum creatinine (Cr) level during hospitalization. RESULTS: The prevalence of CKD and ARF in the whole RETAKO cohort was 5...
March 13, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38490263/randomized-trial-promoting-cancer-genetic-risk-assessment-when-genetic-counseling-cost-removed-1-year-follow-up
#39
JOURNAL ARTICLE
Jinghua An, Jean McDougall, Yong Lin, Shou-En Lu, Scott T Walters, Emily Heidt, Antoinette Stroup, Lisa Paddock, Sherry Grumet, Deborah Toppmeyer, Anita Y Kinney
PURPOSE: Cancer Genetic Risk Assessment (CGRA) is recommended for women with ovarian and high-risk breast cancer. However, the underutilization of CGRA has long been documented, and cost has been a major barrier. In this randomized controlled trial, a Tailored Counseling and Navigation (TCN) intervention significantly improved CGRA uptake at 6-month follow-up, compared with Targeted Print (TP) and Usual Care (UC). We aimed to examine the effect of removing genetic counseling costs on CGRA uptake by 12 months...
March 15, 2024: JNCI Cancer Spectrum
https://read.qxmd.com/read/38490228/systematic-endoscopic-staging-of-mediastinum-to-guide-radiotherapy-planning-in-patients-with-locally-advanced-non-small-cell-lung-cancer-seismic-an-international-multicentre-single-arm-clinical-trial
#40
JOURNAL ARTICLE
Daniel P Steinfort, Gargi Kothari, Neil Wallace, Nicholas Hardcastle, Kanishka Rangamuwa, Edith M T Dieleman, Percy Lee, Peixuan Li, Julie A Simpson, Shaun Yo, Farzad Bashirdazeh, Phan Nguyen, Barton R Jennings, David Fielding, Laurence Crombag, Louis B Irving, Kazuhiro Yasufuku, Jouke T Annema, David E Ost, Shankar Siva
BACKGROUND: Systematic mediastinal lymph node staging by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) improves accuracy of staging in patients with early-stage non-small-cell lung cancer (NSCLC). However, patients with locally advanced NSCLC commonly undergo only selective lymph node sampling. This study aimed to determine the proportion of patients with locally advanced NSCLC in whom systematic endoscopic mediastinal staging identified PET-occult lymph node metastases, and to describe the consequences of PET-occult disease on radiotherapy planning...
March 11, 2024: Lancet Respiratory Medicine
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