Jean E Abraham, Karen Pinilla, Alimu Dayimu, Louise Grybowicz, Nikolaos Demiris, Caron Harvey, Lynsey M Drewett, Rebecca Lucey, Alexander Fulton, Anne N Roberts, Joanna R Worley, Anita Chhabra, Wendi Qian, Anne-Laure Vallier, Richard M Hardy, Steve Chan, Tamas Hickish, Devashish Tripathi, Ramachandran Venkitaraman, Mojca Persic, Shahzeena Aslam, Daniel Glassman, Sanjay Raj, Annabel Borley, Jeremy P Braybrooke, Stephanie Sutherland, Emma Staples, Lucy C Scott, Mark Davies, Cheryl A Palmer, Margaret Moody, Mark J Churn, Jacqueline C Newby, Mukesh B Mukesh, Amitabha Chakrabarti, Rebecca R Roylance, Philip C Schouten, Nicola C Levitt, Karen McAdam, Anne C Armstrong, Ellen R Copson, Emma McMurtry, Marc Tischkowitz, Elena Provenzano, Helena M Earl
PARTNER is a prospective, phase II-III, randomised controlled clinical trial, which recruited patients with Triple Negative Breast Cancer (TNBC)1,2 , who were gBRCA wild type (gBRCAwt)3 . Patients (n=559) were randomised on a 1:1 basis to neoadjuvant carboplatin with paclitaxel +/- olaparib 150mg twice daily, days 3 to 14, for 4 cycles (gap schedule olaparib, research arm) followed by 3 cycles of anthracycline chemotherapy before surgery. The primary endpoint was pathological complete response (pCR)4 , and secondary endpoints included event-free survival (EFS), and overall survival (OS)5 ...
April 8, 2024: Nature