Yu An, Jinchao Zhu, Qihui Xie, Jianzhou Feng, Yanli Gong, Qian Fan, Jiao Cao, Zhi Huang, Weixiong Shi, Qingyuan Lin, Lingling Wu, Chaoyong Yang, Tianhai Ji
To evade immune surveillance, tumor cells express ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) on the surface of their membrane, which degrades extracellular cyclic GMP-AMP (cGAMP), thereby inhibiting the cyclic GMP-AMP synthase (cGAS) stimulator of interferon gene (STING) DNA-sensing pathway. To fully understand this tumor stealth mechanism, it is essential to determine whether other forms of ENPP1 with hydrolytic cGAMP activity also are present in the tumor microenvironment to regulate this innate immune pathway...
March 18, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)