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JOURNAL ARTICLE
Karteek R N Udupa, Mahesh Eshwarappa, K C Gurudev, M S Gireesh, Rajshekar Reddy, Mohammed Yousuff
Minimal change disease (MCD) is the most common cause of nephrotic syndrome (NS) in children, and in adults, it contributes to 10%-25% of NS. MCD in adults follows a slightly different course associated with increased incidence of steroid resistance, hematuria, and HTN. This is a prospective-record analysis study aimed to analyze the profile of MCD in adults, response to treatment, and relapse rates. A retrospective observational study was carried out and data were collected retrospectively from all biopsy-proven MCD patients between 2012 and 2018...
May 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
#22
JOURNAL ARTICLE
Bin Ni, Dongliang Zhang, Hai Zhou, Ming Zheng, Zijie Wang, Jun Tao, Zhijian Han, Xiaobin Ju, Ruoyun Tan, Min Gu
OBJECTIVE: To investigate the role of Interleukin-34 (IL-34) in acute T cell-mediated rejection (TCMR) following renal transplantation. METHODS: The mice acute TCMR model of renal transplantation was established and identified by hematoxylin and eosin (HE) and immunohistochemistry (IHC) staining. Then, IHC staining of IL-34 was also performed to determine the expression of IL-34 in allografts. Recipients were infected with IL-34 overexpression adeno-associated virus, infection efficiency of which was estimated by enzyme linked immunosorbent assay (ELISA), Western blot, and immunofluorescence...
January 15, 2024: Heliyon
#23
Carlo Pace Napoleone, Enrico Aidala, Maria Teresa Cascarano, Luca Deorsola, Stefania Iannandrea, Annalisa Longobardo, Enrico Bonaveglio, Mattia Zanin, Licia Peruzzi
Background A systemic inflammatory response is triggered in patients undergoing cardiothoracic surgery with cardiopulmonary bypass. This response is particularly evident in pediatric patients, especially if of low weight and after undergoing long cardio-pulmonary by-pass (CPB), and can severely impair surgical result. Objectives Adsorptive blood purification techniques have been proposed to limit this systemic inflammatory response. To test its efficacy, we added the hemoadsorption filter Jafron HA 380 to CPB in a very compromised pediatric patient who underwent heart transplantation...
January 13, 2024: Cardiorenal Medicine
#24
JOURNAL ARTICLE
Sylvain Bodard, Louise Denis, Georges Chabouh, Jacques Battaglia, Dany Anglicheau, Olivier Hélénon, Jean-Michel Correas, Olivier Couture
OBJECTIVES: Kidney diseases significantly impact individuals' quality of life and strongly reduce life expectancy. Glomeruli play a crucial role in kidney function. Current imaging techniques cannot visualize them due to their small size. Sensing ultrasound localization microscopy (sULM) has shown promising results for visualizing in vivo the glomeruli of human kidney grafts. This study aimed to evaluate the ability of sULM to visualize glomeruli in vivo in native human kidneys despite their depth and a shorter duration of ultrasound acquisition limited by the period of the patient's apnea...
January 13, 2024: Investigative Radiology
#25
JOURNAL ARTICLE
Selina Wrublewsky, Cedric Wilden, Caroline Bickelmann, Michael D Menger, Matthias W Laschke, Emmanuel Ampofo
Clinical islet transplantation is limited by ischemia-induced islet cell death. Recently, it has been reported that the absent in melanoma (AIM)2 inflammasome is upregulated by ischemic cell death due to recognition of aberrant cytoplasmic self-dsDNA. However, it is unknown whether AIM2 determines the outcome of islet transplantation. To investigate this, isolated wild type (WT) and AIM2 -deficient ( AIM2-/- ) islets were exposed to oxygen-glucose deprivation to mimic ischemia, and their viability, endocrine function, and interferon (IFN) signaling were assessed...
December 20, 2023: Cells
#26
JOURNAL ARTICLE
Shaima Al-Bader, Kamel El-Reshaid, John Madda
Acquired perforating dermatosis (APD) is an adult skin disease characterized by an umbilicated papulonodular rash with transepidermal elimination of dermal components such as collagen and/or elastin. It is frequently associated with multiple medications and diseases such as diabetes and chronic renal failure. It is a disabling disease with severe pruritus in 83.3% of cases and generalized ulcerating lesions that are associated with infections and scarring. Nearly 10% of renal patients are affected. Supportive measurements of disease activity and previous medications failed to halt its natural progression...
March 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
#27
REVIEW
William H Kitchens, Christian P Larsen, I Raul Badell
Belatacept is the first costimulatory blockade agent clinically approved for transplant immunosuppression. Although more than 10 years of study have demonstrated that belatacept offers superior long-term renal allograft and patient survival compared to conventional calcineurin inhibitor (CNI)-based immunosuppression regimens, the clinical adoption of belatacept has continued to lag because of concerns of an early risk of acute cellular rejection (ACR) and various logistical barriers to its administration. In this review, the history of the clinical development of belatacept is examined, along with the findings of the seminal BENEFIT and BENEFIT-EXT trials culminating in the clinical approval of belatacept...
December 2023: KI Reports
#28
JOURNAL ARTICLE
Hemodialysis Access: US for Preprocedural Mapping and Evaluation of Maturity and Access Dysfunction.
Kedar G Sharbidre, Lauren F Alexander, Rakesh K Varma, Alian A Al-Balas, David M Sella, Melanie P Caserta, M Jennings Clingan, Mohd Zahid, Muhammad U Aziz, Michelle L Robbin
Patients with kidney failure require kidney replacement therapy. While renal transplantation remains the treatment of choice for kidney failure, renal replacement therapy with hemodialysis may be required owing to the limited availability and length of time patients may wait for allografts or for patients ineligible for transplant owing to advanced age or comorbidities. The ideal hemodialysis access should provide complication-free dialysis by creating a direct connection between an artery and vein with adequate blood flow that can be reliably and easily accessed percutaneously several times a week...
January 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
#29
JOURNAL ARTICLE
Volker Assfalg, Gregor Miller, Felix Stocker, Norbert Hüser, Daniel Hartmann, Uwe Heemann, Ineke Tieken, Wouter Zanen, Serge Vogelaar, Alexander R Rosenkranz, Stefan Schneeberger, Reinhold Függer, Gabriela Berlakovich, Dirk R Ysebaert, Daniel Jacobs-Tulleneers-Thevissen, Dimitri Mikhalski, Steven van Laecke, Dirk Kuypers, Anja S Mühlfeld, Richard Viebahn, Johann Pratschke, Sebastian Melchior, Ingeborg A Hauser, Bernd Jänigen, Rolf Weimer, Nicolas Richter, Susan Foller, Kevin Schulte, Christine Kurschat, Ana Harth, Christian Moench, Sebastian Rademacher, Martin Nitschke, Bernhard K Krämer, Lutz Renders, Dionysios Koliogiannis, Andreas Pascher, Joachim Hoyer, Julia Weinmann-Menke, Mario Schiffer, Bernhard Banas, Oliver Hakenberg, Vedat Schwenger, Silvio Nadalin, Kai Lopau, Laszlo Piros, Balazs Nemes, Peter Szakaly, Antonia Bouts, Frederike J Bemelman, Jan S Sanders, Aiko P J de Vries, Maarten H L Christiaans, Luuk Hilbrands, Arjan D van Zuilen, Miha Arnol, Dirk Stippel, Roger Wahba
BACKGROUND: Whenever the kidney standard allocation (SA) algorithms according to the Eurotransplant (ET) Kidney Allocation System or the Eurotransplant Senior Program fail, rescue allocation (RA) is initiated. There are 2 procedurally different modes of RA: recipient oriented extended allocation (REAL) and competitive rescue allocation (CRA). The objective of this study was to evaluate the association of patient survival and graft failure with RA mode and whether or not it varied across the different ET countries...
December 11, 2023: Transplantation
#30
REVIEW
Catherine P King, Amelia R Cossart, Nicole M Isbel, Scott B Campbell, Christine E Staatz
PURPOSE: Tremor, headache and insomnia have been linked to the immunosuppressant, tacrolimus. The aim of this systematic review was to determine if there is a correlation between tacrolimus exposure and new-onset tremor, headache and insomnia experienced by adult kidney transplant recipients. METHODS: PubMed, Embase, Cochrane Library and CINAHL databases were searched up to 11 April 2023 for published studies which reported on tacrolimus exposure in adult kidney transplant recipients, alongside information on treatment-emergent neurologic manifestations, including tremor, headache and insomnia...
January 2024: Transplantation Reviews
#31
JOURNAL ARTICLE
Naomi Pode-Shakked, Megan Slack, Nambirajan Sundaram, Ruth Schreiber, Kyle W McCracken, Benjamin Dekel, Michael Helmrath, Raphael Kopan
Autosomal Recessive Renal Tubular Dysgenesis (AR-RTD) is a fatal genetic disorder characterized by complete absence or severe depletion of proximal tubules (PT) in patients harboring pathogenic variants in genes involved in the Renin-Angiotensin-Aldosterone System. To uncover the pathomechanism of AR-RTD, differentiation of ACE-/- and AGTR1-/- induced pluripotent stem cells (iPSCs) and AR-RTD patient-derived iPSCs into kidney organoids is leveraged. Comprehensive marker analyses show that both mutant and control organoids generate indistinguishable PT in vitro under normoxic (21% O2) or hypoxic (2% O2) conditions...
December 9, 2023: Nature Communications
#32
JOURNAL ARTICLE
Tadafumi Yokoyama, Naoto Sakumura, Natsumi Inoue, Kazuhide Ohta, Taizo Wada
Oligomeganephronia is a congenital anomaly of the kidney and urinary tract. It is often categorized as one of the hypoplastic kidney conditions. The pathological diagnosis of oligomeganephronia is challenged by the absence of clear diagnostic criteria, which often leads to subjective interpretations by pathologists. This report presents the case of a 7-year-old girl who was diagnosed with oligomeganephronia through a third renal biopsy, which was confirmed by gene analysis revealing PAX2 deletion. Two previous renal biopsies, with the naked eye through a microscope, failed to identify glomerular hypertrophy and sparse glomerular distribution density...
December 7, 2023: Journal of Nephrology
#33
JOURNAL ARTICLE
Çağla Serpil Doğan, Sevgin Taner, Betül Durucu Tiryaki, Demet Alaygut, Neşe Özkayın, Aslıhan Kara, Aylin Gençler, Ayşe Seda Pınarbaşı, Hülya Nalçacıoğlu, Selçuk Yüksel, Okan Akacı, Esra Karabağ Yılmaz, Sevgi Yavuz, Kenan Doğan, Rumeysa Yasemin Çiçek Gülşan, Gülşah Kaya Aksoy, Neslihan Çiçek, Bağdagül Aksu, Nuran Küçük, Fatma Şemsa Altugan, Şenay Zırhlı Selçuk, Funda Baştuğ, Gökçen Erfidan, Bahriye Atmış, Arife Uslu Gökçeoğlu, Esra Nagehan Akyol Önder, Ahmet Mithat Elmacı, Nurcan Cengiz, Kaan Gülleroğlu, Ebru Bekiroğlu Yılmaz, Aslı Çelebi Tayfur, Gülsün Gülay Yılmaz, Sİbel Yel, Cemile Pehlivanoğlu, Cihangir Akgün, Mehtap Akbalık Kara, Beltinge Demircioğlu Kılıç, Özgür Özdemir Şimşek, Melike Yucal, Buket Esen Ağar, Metin Kaya Gürgöze, İsmail Yağmur, Ömer Madsar, Demet Tekcan Karalı, İlknur Girişgen, Ece Demirci Bodur, Elif Çomak, İbrahim Gökçe, Mehtap Kaya, Yılmaz Tabel, Neslihan Günay, Rüveyda Gülmez, Salim Çalışkan
BACKGROUND: Myelomeningocele (MMC) is highly prevalent in developing countries, and MMC-related neurogenic bladder is an important cause of childhood chronic kidney disease (CKD). This nationwide study aimed to evaluate demographic and clinical features of pediatric patients with MMC in Turkey and risk factors associated with CKD stage 5. METHODS: Data from children aged 0-19 years old, living with MMC in 2022, were retrospectively collected from 27 pediatric nephrology centers...
December 2, 2023: Pediatric Nephrology
#34
Nicole Min Hui Loh, Bhavesh Doshi, Ning Qi Pang
This case report highlights the investigation and treatment of a 70-year-old male with cytomegalovirus (CMV) cholangiopathy. The patient underwent a kidney transplant in 2016 and presented 3 years later with the atypical presentation of left shoulder pain associated with dilated biliary tree and mild transaminitis. Initial endoscopic retrograde cholangiopancreatography (ERCP) showed diffuse stricture of the common bile duct, requiring stenting, and over the course of a year multiple stent changes were required to prevent cholestasis...
November 2023: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
#35
JOURNAL ARTICLE
Thomas G Peters, John J Fung, Janet Radcliffe-Richards, Sally Satel, Alvin E Roth, Frank McCormick, Martha Gershun, Arthur J Matas, John P Roberts, Josh Morrison, Glenn M Chertow, Laurie D Lee, Philip J Held, Akinlolu Ojo
Virtually all clinicians agree that living donor renal transplantation is the optimal treatment for permanent loss of kidney function. Yet, living donor kidney transplantation has not grown in the United States for more than 2 decades. A virtual symposium gathered experts to examine this shortcoming and to stimulate and clarify issues salient to improving living donation. The ethical principles of rewarding kidney donors and the limits of altruism as the exclusive compelling stimulus for donation were emphasized...
November 15, 2023: Progress in Transplantation
#36
JOURNAL ARTICLE
Lena Sibulesky, Nicolae Leca, Ramasamy Bakthavatsalam, James D Perkins
BACKGROUND: An increasing number of older patients are undergoing kidney transplant. Because of a finite longevity, more patients will be faced with failing allografts. At present there is a limited understanding of the benefits and risks associated with kidney retransplantation in this challenging population. METHODS: We performed a retrospective analysis of the Organ Procurement and Transplantation Network database of all adults ≥70 undergoing kidney retransplant from January 1, 2014 to December 31, 2022...
January 2024: Clinical Transplantation
#37
JOURNAL ARTICLE
Mel Berger, Mary Baliker, Teun Van Gelder, Georg A Böhmig, Roslyn B Mannon, Deepali Kumar, Steve Chadban, Peter Nickerson, Laurie A Lee, Arjang Djamali
Chronic active antibody-mediated rejection (caAMR) is arguably the most important cause of late kidney allograft failure. However, there are no US Food and Drug Administration (FDA)-approved treatments for acute or chronic AMR and there is no consensus on effective treatment. Many trials in transplantation have failed because of slow and/or inadequate enrollment, and no new agent has been approved by the FDA for transplantation in over a decade. Several lines of evidence suggest that interleukin-6 is an important driver of AMR, and clazakizumab, a humanized monoclonal antibody that neutralizes interleukin-6, has shown promising results in phase 2 studies...
November 9, 2023: Transplantation
#38
JOURNAL ARTICLE
Mohammadreza Nemati, Haonan Zhang, Michael Sloma, Dulat Bekbolsynov, Hong Wang, Stanislaw Stepkowski, Kevin S Xu
Kidney transplantation can significantly enhance living standards for people suffering from end-stage renal disease. A significant factor that affects graft survival time (the time until the transplant fails and the patient requires another transplant) for kidney transplantation is the compatibility of the Human Leukocyte Antigens (HLAs) between the donor and recipient. In this paper, we propose 4 new biologically-relevant feature representations for incorporating HLA information into machine learning-based survival analysis algorithms...
November 2023: Artificial Intelligence in Medicine
#39
JOURNAL ARTICLE
Ekamol Tantisattamo, Kamyar Kalantar-Zadeh
PURPOSE OF REVIEW: There are limited studies on the benefits of low dietary protein intake (DPI) and plant-dominant diets to delay kidney allograft dysfunction. We evaluate evidence regarding the association or effects of the amount and type of DPI on allograft function. RECENT FINDINGS: There is conflicting evidence regarding the benefits of low DPI and plant-dominant diet including PLADO and PLAFOND on kidney allograft function. Taking the strength of evidence including study design, sample size, and time to follow-up, the proposed amount of DPI to slow the progression of allograft dysfunction, avoid negative nitrogen balance, and skeletal muscle mass loss is 1...
November 6, 2023: Current Opinion in Nephrology and Hypertension
#40
Hamza Attiq, Ehsan Elahi, Muhammad Haseeb Ashraf, Hira Khalid
Senior-Loken syndrome (SLS) is a rare autosomal recessive disorder affecting the eyes and the kidneys. It is an extremely rare disorder with an incidence of 1/1,000,000. Like most hereditary disorders, it is more commonly seen in families with consanguineous marriages. Here, we present a case of a 35-year-old male with a complicated past medical history, who presented to us in the outpatient department for kidney transplant consideration. The patient was diagnosed case of Senior-Loken syndrome with a family history of autoimmune diseases, renal disease, and multiple unexplained miscarriages...
September 2023: Curēus
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