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https://www.readbyqxmd.com/read/28154994/neutrophil-to-lymphocyte-ratio-predicts-outcome-in-limited-disease-small-cell-lung-cancer
#1
Lukas Käsmann, Louisa Bolm, Steven E Schild, Stefan Janssen, Dirk Rades
INTRODUCTION: Patients with limited disease small-cell lung cancer (SCLC) receive radiochemotherapy followed by prophylactic cranial irradiation. The prognosis of these patients remains poor with a median survival of 16-24 months. Systemic inflammation was suggested as an important prognostic factor for outcomes. This study investigated the impact of systemic inflammation measured with neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) at first diagnosis in patients with limited disease SCLC for outcomes...
February 2, 2017: Lung
https://www.readbyqxmd.com/read/28151892/association-between-rdw-and-stent-thrombosis-in-patients-with-st-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#2
Abdullah Tunçez, Mehmet Serkan Çetin, Elif Hande Özcan Çetin, Samet Ylmaz, Ahmet Korkmaz, Fatih Mehmet Uçar
Stent thrombosis is a rare but potentially fatal complication of percutaneous coronary interventions (PCIs). In recent years, the predictive and prognostic value of the red cell distribution width (RDW) as an indicator of inflammation has been shown in many cardiovascular diseases. Aim of this study was to examine the predictive value of RDW for stent thrombosis in patients who underwent successful stent implantation for ST-elevation myocardial infarction (STEMI).In this retrospective study, 146 patients who underwent successful PCI to native coronary artery due to STEMI previously and presented with acute coronary syndrome with stent thrombosis were included (stent thrombosis group)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28145612/coronary-artery-perforations-after-contemporary-percutaneous-coronary-interventions-evaluation-of-incidence-risk-factors-outcomes-and-predictors-of-mortality
#3
Jessica Parsh, Milan Seth, Jacqueline Green, Nadia R Sutton, Stanley Chetcuti, Simon Dixon, Paul M Grossman, Akshay Khandelwal, James M Dupree, Hitinder S Gurm
OBJECTIVES: We sought to evaluate the incidence, risk factors, in-hospital, and long-term outcomes and predictors of mortality of coronary artery perforations (CAP) in the contemporary percutaneous coronary intervention (PCI) era. BACKGROUND: CAP is a rare but serious complication of PCI associated with increased risk of morbidity and mortality. METHODS: We included 181,590 procedures performed across 47 hospitals in Michigan from January 1, 2010 to December 31, 2015...
February 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28133687/gender-differences-in-risk-profile-and-outcome-of-middle-eastern-patients-undergoing-percutaneous-coronary-intervention
#4
Mohamad I Jarrah, Ayman J Hammoudeh, Dalal B Al-Natour, Yousef S Khader, Ramzi A Tabbalat, Imad A Alhaddad, Susan M Kullab
To determine the gender differences in cardiovascular risk profile and outcomes among patients undergoing percutaneous coronary intervention (PCI). Methods: In a prospective multicenter study of consecutive Middle Eastern patients managed with PCI from January 2013 to February 2014 in 12 tertiary care centers in Amman and Irbid, Jordan. Clinical and coronary angiographic features, and major cardiovascular events were assessed for both genders from hospital stay to 1 year. Results: Women comprised 20.6% of 2426 enrolled patients, were older (mean age 62...
February 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28131744/troponin-i-elevation-and-all-cause-mortality-after-elective-percutaneous-coronary-interventions
#5
Roberto Muniz Ferreira, Nelson Albuquerque de Souza E Silva, Lúcia Helena Alvares Salis, Rafael Ramos Mendes da Silva, Paula Dias Maia, Lucas Felipe Bastos Horta, Eliene Ferreira Salles, Henrique Moraes Pinto Nunes, Joana Beatriz Moutinho de Oliveira, Yasminne Pascoal de Sousa Domingues, Clarissa Castrighini Macedo de Sousa
BACKGROUND/PURPOSE: Although troponin I (TnI) elevation and myocardial injury after percutaneous coronary interventions (PCI) are frequent findings, their prognoses remain controversial. We aimed to determine the association between any or ≥5 times TnI elevation after elective PCI and subsequent one year mortality rates and long term survival. METHODS: Consecutive patients admitted for elective PCI between January 2013 and December 2014 were retrospectively analyzed by chart review in two hospitals in Rio de Janeiro...
January 17, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28129742/association-of-serum-transaminases-with-short-and-long-term-outcomes-in-patients-with-st-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#6
Ming Gao, Yi Cheng, Yang Zheng, Weihua Zhang, Lin Wang, Ling Qin
BACKGROUND: Alanine transaminase (ALT) and aspartate aminotransferase (AST) are referred to as liver transaminases. Although used routinely in clinical practice for decades, their role as predictors of mortality has not been examined until recently. We studied the predictive value of these serum transaminases in patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI). METHODS: We analyzed records of 2417 consecutive STEMI patients with no preexisting liver disease who were treated with primary PCI at the Cardiovascular Center in the First Hospital of Jilin University...
January 28, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28111212/global-quantification-of-left-ventricular-myocardial-perfusion-at-dynamic-ct-imaging-prognostic-value
#7
Felix G Meinel, Julian L Wichmann, U Joseph Schoepf, Francesca Pugliese, Ullrich Ebersberger, Gladys G Lo, Yeon Hyeon Choe, Yining Wang, Christian Tesche, Sabrina Segreto, Wolfgang G Kunz, Kolja M Thierfelder, Fabian Bamberg, Carlo N De Cecco
BACKGROUND: There is no published data on the prognostic value of global myocardial perfusion values at stress dynamic CT myocardial perfusion imaging (CTMPI). METHODS: Data of 144 patients from 6 centers who had undergone coronary CT angiography (coronary CTA) and CTMPI were assessed. Coronary CTA studies were acquired at rest; CTMPI was performed under vasodilator stress. Coronary CTA data were evaluated for coronary artery stenosis (≥50% luminal narrowing) on a per-vessel basis...
January 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28092977/hypertension-is-associated-with-increased-mortality-in-patients-with-ischaemic-heart-disease-after-revascularization-with-percutaneous-coronary-intervention-a-report-from-scaar
#8
Ott Saluveer, Björn Redfors, Oskar Angerås, Christian Dworeck, Inger Haraldsson, Charlotta Ljungman, Petur Petursson, Jacob Odenstedt, Dan Ioanes, Peter Lundgren, Sebastian Völz, Truls Råmunddal, Bert Andersson, Elmir Omerovic, Niklas Bergh
BACKGROUND: The prognostic role of hypertension on long-term survival after percutaneous coronary intervention (PCI) is limited and inconsistent. We hypothesize that hypertension increases long-term mortality after PCI. METHODS: We analyzed data from SCAAR (Swedish Coronary Angiography and Angioplasty Registry) for all consecutive patients admitted coronary care units in Sweden between January 1995 and May 2013 and who underwent PCI due to ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI)/unstable angina (UA) or stable angina pectoris...
January 16, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28072688/factors-associated-with-unattained-ldl-cholesterol-goals-in-chinese-patients-with-acute-coronary-syndrome-one-year-after-percutaneous-coronary-intervention
#9
Wenduo Zhang, Fusui Ji, Xue Yu, Xinyue Wang
Reducing low-density lipoprotein cholesterol (LDL-C) to target ≤1.81 mmol/L is a common therapeutic goal after acute coronary syndrome (ACS). This study aimed to examine the factors associated with reaching or not this LDL-C target after 1 year of optimal statin therapy postpercutaneous coronary intervention (PCI). This was a retrospective study of 633 consecutive prospectively enrolled patients with ACS treated between January 2011 and December 2012 at the Beijing Hospital (China). All patients were treated with PCI and statins for 1 year...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28065620/treatment-response-and-prophylactic-cranial-irradiation-are-prognostic-factors-in-a-real-life-limited-disease-small-cell-lung-cancer-patient-cohort-comprehensively-staged-with-cranial-magnetic-resonance-imaging
#10
Chukwuka Eze, Olarn Roengvoraphoj, Maximilian Niyazi, Guido Hildebrandt, Rainer Fietkau, Claus Belka, Farkhad Manapov
INTRODUCTION: Prophylactic cranial irradiation (PCI) has proven to decrease the incidence of brain metastases (BMs), with a modest improvement in survival. PATIENTS AND METHODS: The impact of PCI was evaluated in 184 patients treated with chemoradiotherapy. PCI was applied to patients with disease with partial and complete response only when cranial magnetic resonance imaging before and after primary treatment revealed no BMs. Correlation between PCI and overall survival (OS), BM-free survival (BMFS), and time to progression (TTP) was analyzed to describe survival within subgroups...
November 21, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28057001/improved-trends-in-cardiovascular-complications-among-subjects-with-type-2-diabetes-in-korea-a-nationwide-study-2006-2013
#11
Chang Hee Jung, Jin Ook Chung, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko, Joong-Yeol Park
BACKGROUND: Representative data on the secular trends in cardiovascular disease (CVD) are limited in Asian populations with diabetes. We aimed to estimate the temporal trends in cardiovascular complications using Korean nationwide whole population-based claims data in subjects with and without diabetes. METHODS: Type 2 diabetes was defined as a current medication history of anti-diabetic drugs and the presence of International Classification of Diseases (ICD)-10 codes (E11-E14) as diagnosis...
January 6, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28040280/management-and-outcome-of-patients-with-acute-myocardial-infarction-presenting-with-pacemaker-rhythm
#12
Noemi Bertel, Fabienne Witassek, Milo Puhan, Paul Erne, Hans Rickli, Barbara Naegeli, Giovanni Pedrazzini, Jean-Christophe Stauffer, Dragana Radovanovic
BACKGROUND: Diagnosis of acute myocardial infarction (MI) is challenging in pacemaker patients. Little is known about this patient group. METHODS: Patients with MI enrolled in the Swiss national AMIS Plus registry between January 2005 and December 2015 were analyzed. All patients with either paced ventricular rhythm or sinus rhythm with intrinsic ventricular conduction (IVC) were included in this study. Outcomes using crude data and propensity score matching were compared between patients with pacemaker rhythm and patients with IVC...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28040190/comparison-of-outcomes-of-women-versus-men-with-non-st-elevation-acute-coronary-syndromes-undergoing-percutaneous-coronary-intervention-from-the-japanese-nationwide-registry
#13
Yohei Numasawa, Taku Inohara, Hideki Ishii, Toshiki Kuno, Masaki Kodaira, Shun Kohsaka, Kenshi Fujii, Shiro Uemura, Tetsuya Amano, Kazushige Kadota, Masato Nakamura
Previous studies have reported that women have worse outcomes than men after percutaneous coronary intervention (PCI), especially in patients with ST-elevation myocardial infarction. However, gender-related differences in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS) have not been thoroughly investigated. In the Japanese nationwide registry, a total of 43,239 patients with NSTE-ACS from 861 hospitals underwent PCI in 2014. Overall, 11,326 patients (26.2%) were women. The women were older (75...
December 18, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28034708/influence-of-age-and-gender-on-clinical-outcomes-following-percutaneous-coronary-intervention-for-acute-coronary-syndromes
#14
Hanan Idris, John K French, Ibrahim M Shugman, Andrew P Hopkins, Craig P Juergens, Liza Thomas
BACKGROUND: Gender and age are non-modifiable factors influencing clinical outcomes in acute coronary syndromes (ACS). There is evidence that coronary artery disease pathophysiology varies in women. We therefore evaluated the effect of age and gender on clinical outcomes in patients with ACS undergoing percutaneous coronary interventions (PCI). METHODS: Among 3178 (25% female) consecutive ACS patients who underwent PCI at Liverpool Hospital, Sydney from 2003 to 2010, using femoral access in 98% of cases, we determined late events including mortality, myocardial infarction and bleeding according to Bleeding Academic Research Consortium (BARC) criteria...
December 2, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28025925/contemporary-trends-in-oral-antiplatelet-agent-use-in-patients-treated-with-percutaneous-coronary-intervention-for-acute-coronary-syndrome
#15
Kibum Kim, Todd A Lee, Daniel R Touchette, Robert J DiDomenico, Amer K Ardati, Surrey M Walton
BACKGROUND: Recent trials demonstrated the efficacy of prasugrel and ticagrelor compared with clopidogrel in the reduction of cardiovascular complications in patients with acute coronary syndrome (ACS). However, it is unclear how use of the 3 antiplatelet medications has changed in commercially insured patients since the advent of the new agents. OBJECTIVES: To (a) describe the adoption of prasugrel and ticagrelor in patients who received percutaneous coronary intervention (PCI) for the onset of ACS and (b) explore patient factors associated with the selection of the drug to provide insight into utilization patterns of these antiplatelet agents...
January 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27981260/once-daily-high-dose-radiation-%C3%A2-60-gy-treatment-in-limited-stage-small-cell-lung-cancer
#16
Amir Zahra, Tangel Chang, Taher Abu Hejleh, Muhammad Furqan, Gerald H Clamon, Sudershan K Bhatia, John M Watkins, Sarah L Mott, Logan L Ahmann, Kellie L Bodeker, Douglas R Spitz, John M Buatti, Bryan G Allen
BACKGROUND: To investigate outcomes and prognostic factors in patients treated with once daily high-dose (≥60 Gy) radiation therapy (HDRT) and concurrent platinum-based chemotherapy in limited stage small cell lung cancer (LS-SCLC). While we await current phase III trials to determine optimal radiation dose fractionation schemes in LS-SCLC, we report our experience in LS-SCLC with once daily HDRT. We hypothesized that HDRT would achieve similar efficacy and tolerability as twice daily therapy...
November 2016: J Oncol Transl Res
https://www.readbyqxmd.com/read/27976460/interventional-therapies-and-in-hospital-outcomes-in-acute-coronary-syndromes-complicated-by-von-willebrand-disease
#17
P F Fogarty, A Blair, R Vega, W H Matthai, P A Gimotty
INTRODUCTION: von Willebrand disease (VWD) is one of the most common inherited bleeding disorders. AIM: Investigate the impact of the VWD bleeding tendency on in-hospital management of acute coronary syndromes (ACS). METHODS: Using discharge data from the National Inpatient Sample (NIS), the features of presentation and in-hospital treatment among ACS hospital discharges with and without a VWD diagnosis were investigated. A total of 264 case discharges and 705 860 control discharges were identified...
December 14, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/27968766/indications-for-fibrinolysis-in-patients-with-st-segment-elevation-myocardial-infarction-from-guidelines-to-practice
#18
C Boivineau, L Orion, J Dimet, E Boiffard
BACKGROUND: European guidelines on managing ST segment elevation myocardial infarction (STEMI) during the first 12hours recommend fibrinolysis when the time elapsing between the first medical contact and balloon time (FMCBT) is more than 120minutes. AIM: To assess the real-life clinical efficacy of guidelines on fibrinolysis in managing STEMI and identify obstacles to their everyday implementation. METHODS: An observational study based on a permanent registry of reperfusion strategies and timing among patients treated in a French general hospital for STEMI with chest pain lasting for less than two hours...
November 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27923460/comparison-of-characteristics-and-complications-in-men-versus-women-undergoing-chronic-total-occlusion-percutaneous-intervention
#19
Vinoda Sharma, William Wilson, William Smith, Margaret McEntegart, Keith Oldroyd, Novalia Sidik, Alan Bagnall, Mohaned Egred, John Irving, Julian Strange, Thomas Johnson, Simon Walsh, Colm Hanratty, James Spratt
Gender differences exist in clinical outcomes after routine percutaneous coronary intervention (PCI), but studies reporting such outcomes after chronic total occlusion (CTO) PCI are limited. We assessed the characteristics and outcomes of female patients undergoing CTO PCI. We retrospectively analyzed a dedicated national (United Kingdom) prospective CTO database from 2011 to 2015 for outcomes and characteristics of female patients undergoing CTO PCI (unmatched and propensity matched). Female patients constituted 20...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27912201/anxiety-levels-of-patients-undergoing-coronary-procedures-in-the-catheterization-laboratory
#20
Ronak Delewi, Wieneke Vlastra, Wim J Rohling, Tineke C Wagenaar, Max Zwemstra, Martin G Meesterman, Marije M Vis, Joanna J Wykrzykowska, Karel T Koch, Robbert J de Winter, Jan Baan, Jan J Piek, Mirjam A G Sprangers, José P S Henriques
BACKGROUND: High levels of anxiety are associated with worse outcomes in coronary artery disease patients. Little is known about anxiety levels in patients undergoing coronary procedures. Our objective is to examine the levels of anxiety in patients undergoing coronary angiography (CAG) or percutaneous coronary intervention (PCI) during the different phases of hospital stay and to evaluate which patient characteristics are associated with increased anxiety. METHODS: Patients undergoing CAG or PCI between April 2009 and April 2010 were included in this prospective cohort study...
February 1, 2017: International Journal of Cardiology
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